EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	27139570	Missense_Mutation	NA	V88F	0.11
BLCA	chr6	27139465	Missense_Mutation	NA	E53Q	0.09
BLCA	chr6	27139548	Silent	NA	K80K	0.17
BLCA	chr6	27139602	Silent	novel	L98L	0.22
BLCA	chr6	27139461	Missense_Mutation	rs753701748	I51M	0.56
BLCA	chr6	27139451	Missense_Mutation	novel	S48C	0.42
BLCA	chr6	27139567	Missense_Mutation	rs376974407	V87M	0.82
BLCA	chr6	27139458	Silent	novel	L50L	0.14
BLCA	chr6	27139529	Missense_Mutation	novel	T74K	0.29
BRCA	chr6	27139680	3'UTR	novel		0.36
BRCA	chr6	27139581	Silent	rs570548268	L91L	0.2
CESC	chr6	27139477	Missense_Mutation	novel	G57R	0.34
CESC	chr6	27139414	Missense_Mutation	NA	R36W	0.48
COAD	chr6	27139536	Missense_Mutation	rs531123491	H76Q	0.37
COAD	chr6	27139474	Missense_Mutation	rs200159567	R56C	0.39
COAD	chr6	27139417	Missense_Mutation	rs768322550	R37C	0.4
COAD	chr6	27139431	Silent	NA	R41R	0.1
DLBC	chr6	27139503	Silent	novel	N65N	0.35
GBM	chr6	27139602	Silent	novel	L98L	0.27
HNSC	chr6	27139347	Missense_Mutation	novel	K13N	0.26
LIHC	chr6	27139438	Missense_Mutation	novel	V44M	0.15
LIHC	chr6	27139658	3'UTR	novel		0.15
LUAD	chr6	27139606	Missense_Mutation	NA	G100C	0.36
LUAD	chr6	27139430	Missense_Mutation	NA	R41L	0.25
LUAD	chr6	27139498	Missense_Mutation	NA	E64K	0.23
LUAD	chr6	27139500	Silent	rs150377743	E64E	0.22
LUAD	chr6	27139611	Missense_Mutation	novel	F101L	0.24
LUSC	chr6	27139343	Missense_Mutation	NA	G12E	0.14
LUSC	chr6	27139587	Silent	novel	R93R	0.34
LUSC	chr6	27139361	Missense_Mutation	NA	R18L	0.3
LUSC	chr6	27139494	Missense_Mutation	novel	F62L	0.35
MESO	chr6	27139429	Missense_Mutation	rs761496441	R41C	0.4
READ	chr6	27139576	Missense_Mutation	rs746626210	A90T	0.6
READ	chr6	27139641	3'UTR	novel		0.42
READ	chr6	27139449	Silent	novel	I47I	0.38
SKCM	chr6	27139515	Silent	NA	D69D	0.31
SKCM	chr6	27139478	Missense_Mutation	rs140361782	G57E	0.17
STAD	chr6	27139526	Missense_Mutation	NA	Y73C	0.12
STAD	chr6	27139380	Silent	NA	R24R	0.4
STAD	chr6	27139440	Silent	novel	V44V	0.18
STAD	chr6	27139385	Missense_Mutation	rs753685066	N26S	0.22
UCEC	chr6	27139361	Missense_Mutation	novel	R18H	0.34
UCEC	chr6	27139361	Missense_Mutation	novel	R18H	0.48
UCEC	chr6	27139454	Missense_Mutation	novel	G49D	0.31
UCEC	chr6	27139577	Missense_Mutation	novel	A90V	0.4
UCEC	chr6	27139380	Silent	NA	R24R	0.21
UCEC	chr6	27139479	Silent	rs565433112	G57G	0.24
UCEC	chr6	27139414	Missense_Mutation	NA	R36W	0.33
UCEC	chr6	27139532	Missense_Mutation	novel	E75G	0.28
UCEC	chr6	27139596	Silent	novel	R96R	0.45
UCEC	chr6	27139668	3'UTR	novel		0.34
UCEC	chr6	27139480	Missense_Mutation	NA	V58L	0.32
UCEC	chr6	27139518	Silent	rs760177834	A70A	0.12
UCEC	chr6	27139336	Missense_Mutation	novel	G10C	0.16
UCEC	chr6	27139334	Missense_Mutation	novel	K9R	0.43
UCEC	chr6	27139426	Missense_Mutation	rs773953710	R40C	0.15
UCEC	chr6	27139575	Silent	rs777436970	Y89Y	0.23
UCEC	chr6	27139554	Silent	NA	V82V	0.1
UCEC	chr6	27139318	Missense_Mutation	NA	R4C	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.029	Kaplan-Meier Survival Analysis
MESO	0.00015	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.00027	Kaplan-Meier Survival Analysis
PRAD	0.049	Kaplan-Meier Survival Analysis
LUSC	0.018	Kaplan-Meier Survival Analysis
KIRP	0.00031	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
PAAD	0.00089	Kaplan-Meier Survival Analysis
CESC	0.00032	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
LUAD	0.0051	Kaplan-Meier Survival Analysis
OV	0.00083	Kaplan-Meier Survival Analysis

Description

RBPome

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000276180 (Gene tree)
Gene ID: 8294
Gene Symbol: HIST1H4I
Alias: H4/m|H4FM
Full Name: histone cluster 1 H4 family member i
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 1,294 bases
Position: chr6:27,138,588-27,139,881
Accession: 4793
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000615353	HIST1H4I-201	1294	-	ENSP00000481486	103 (aa)	-	P62805

Gene Model

Click here to download ENSG00000276180's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000276180's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000276180	HIST1H4I	100	99.029	WBGene00001941	his-67	100	99.029	Caenorhabditis_elegans
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000278705	HIST1H4B	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000276966	HIST1H4E	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000275126	HIST1H4L	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000197061	HIST1H4C	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000197837	HIST4H4	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000274618	HIST1H4F	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000270882	HIST2H4A	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	100.000	ENSG00000270276	HIST2H4B	100	100.000	Homo_sapiens
ENSG00000276180	HIST1H4I	100	92.233	YBR009C		100	92.233	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0000228	nuclear chromosome	14718166.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000786	nucleosome	21636898.24699735.25615412.	IDA	Component
GO:0000786	nucleosome	3035717.	TAS	Component
GO:0000788	nuclear nucleosome	20498094.	IDA	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	3035717.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	14585971.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006334	nucleosome assembly	21873635.	IBA	Process
GO:0006334	nucleosome assembly	20498094.21636898.24699735.25615412.	IDA	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0006352	DNA-templated transcription, initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016233	telomere capping	-	TAS	Process
GO:0019904	protein domain specific binding	22368283.	IPI	Function
GO:0032200	telomere organization	17675446.	TAS	Process
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045653	negative regulation of megakaryocyte differentiation	18474616.	IDA	Process
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051290	protein heterotetramerization	20498094.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.