EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr627139570Missense_MutationNAV88F0.11
BLCAchr627139465Missense_MutationNAE53Q0.09
BLCAchr627139548SilentNAK80K0.17
BLCAchr627139602SilentnovelL98L0.22
BLCAchr627139461Missense_Mutationrs753701748I51M0.56
BLCAchr627139451Missense_MutationnovelS48C0.42
BLCAchr627139567Missense_Mutationrs376974407V87M0.82
BLCAchr627139458SilentnovelL50L0.14
BLCAchr627139529Missense_MutationnovelT74K0.29
BRCAchr6271396803'UTRnovel0.36
BRCAchr627139581Silentrs570548268L91L0.2
CESCchr627139477Missense_MutationnovelG57R0.34
CESCchr627139414Missense_MutationNAR36W0.48
COADchr627139536Missense_Mutationrs531123491H76Q0.37
COADchr627139474Missense_Mutationrs200159567R56C0.39
COADchr627139417Missense_Mutationrs768322550R37C0.4
COADchr627139431SilentNAR41R0.1
DLBCchr627139503SilentnovelN65N0.35
GBMchr627139602SilentnovelL98L0.27
HNSCchr627139347Missense_MutationnovelK13N0.26
LIHCchr627139438Missense_MutationnovelV44M0.15
LIHCchr6271396583'UTRnovel0.15
LUADchr627139606Missense_MutationNAG100C0.36
LUADchr627139430Missense_MutationNAR41L0.25
LUADchr627139498Missense_MutationNAE64K0.23
LUADchr627139500Silentrs150377743E64E0.22
LUADchr627139611Missense_MutationnovelF101L0.24
LUSCchr627139343Missense_MutationNAG12E0.14
LUSCchr627139587SilentnovelR93R0.34
LUSCchr627139361Missense_MutationNAR18L0.3
LUSCchr627139494Missense_MutationnovelF62L0.35
MESOchr627139429Missense_Mutationrs761496441R41C0.4
READchr627139576Missense_Mutationrs746626210A90T0.6
READchr6271396413'UTRnovel0.42
READchr627139449SilentnovelI47I0.38
SKCMchr627139515SilentNAD69D0.31
SKCMchr627139478Missense_Mutationrs140361782G57E0.17
STADchr627139526Missense_MutationNAY73C0.12
STADchr627139380SilentNAR24R0.4
STADchr627139440SilentnovelV44V0.18
STADchr627139385Missense_Mutationrs753685066N26S0.22
UCECchr627139361Missense_MutationnovelR18H0.34
UCECchr627139361Missense_MutationnovelR18H0.48
UCECchr627139454Missense_MutationnovelG49D0.31
UCECchr627139577Missense_MutationnovelA90V0.4
UCECchr627139380SilentNAR24R0.21
UCECchr627139479Silentrs565433112G57G0.24
UCECchr627139414Missense_MutationNAR36W0.33
UCECchr627139532Missense_MutationnovelE75G0.28
UCECchr627139596SilentnovelR96R0.45
UCECchr6271396683'UTRnovel0.34
UCECchr627139480Missense_MutationNAV58L0.32
UCECchr627139518Silentrs760177834A70A0.12
UCECchr627139336Missense_MutationnovelG10C0.16
UCECchr627139334Missense_MutationnovelK9R0.43
UCECchr627139426Missense_Mutationrs773953710R40C0.15
UCECchr627139575Silentrs777436970Y89Y0.23
UCECchr627139554SilentNAV82V0.1
UCECchr627139318Missense_MutationNAR4C0.25

Copy Number Variations (CNVs)
CancerTypeFreq Q-value

Survival Analysis
CancerP-value Q-value
KIRC0.029

Kaplan-Meier Survival Analysis

MESO0.00015

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

SKCM0.00027

Kaplan-Meier Survival Analysis

PRAD0.049

Kaplan-Meier Survival Analysis

LUSC0.018

Kaplan-Meier Survival Analysis

KIRP0.00031

Kaplan-Meier Survival Analysis

COAD0.044

Kaplan-Meier Survival Analysis

PAAD0.00089

Kaplan-Meier Survival Analysis

CESC0.00032

Kaplan-Meier Survival Analysis

UCEC0.028

Kaplan-Meier Survival Analysis

LUAD0.0051

Kaplan-Meier Survival Analysis

OV0.00083

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000276180 (Gene tree)
Gene ID
8294
Gene Symbol
HIST1H4I
Alias
H4/m|H4FM
Full Name
histone cluster 1 H4 family member i
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
1,294 bases
Position
chr6:27,138,588-27,139,881
Accession
4793
RBP type
non-canonical RBP
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000615353HIST1H4I-2011294-ENSP00000481486103 (aa)-P62805
Gene Model
Click here to download ENSG00000276180's gene model file
Pathways
Pathway IDPathway NameSource
hsa05034AlcoholismKEGG
hsa05203Viral carcinogenesisKEGG
hsa05322Systemic lupus erythematosusKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000276180's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000276180HIST1H4I10099.029WBGene00001941his-6710099.029Caenorhabditis_elegans
ENSG00000276180HIST1H4I100100.000ENSG00000278705HIST1H4B100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000276966HIST1H4E100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000275126HIST1H4L100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000197061HIST1H4C100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000197837HIST4H4100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000274618HIST1H4F100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000270882HIST2H4A100100.000Homo_sapiens
ENSG00000276180HIST1H4I100100.000ENSG00000270276HIST2H4B100100.000Homo_sapiens
ENSG00000276180HIST1H4I10092.233YBR009C10092.233Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000183chromatin silencing at rDNA-TASProcess
GO:0000228nuclear chromosome14718166.IDAComponent
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000786nucleosome21636898.24699735.25615412.IDAComponent
GO:0000786nucleosome3035717.TASComponent
GO:0000788nuclear nucleosome20498094.IDAComponent
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding3035717.TASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus14585971.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006303double-strand break repair via nonhomologous end joining-TASProcess
GO:0006334nucleosome assembly21873635.IBAProcess
GO:0006334nucleosome assembly20498094.21636898.24699735.25615412.IDAProcess
GO:0006335DNA replication-dependent nucleosome assembly14718166.IDAProcess
GO:0006336DNA replication-independent nucleosome assembly14718166.IDAProcess
GO:0006352DNA-templated transcription, initiation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016233telomere capping-TASProcess
GO:0019904protein domain specific binding22368283.IPIFunction
GO:0032200telomere organization17675446.TASProcess
GO:0032991protein-containing complex14718166.IDAComponent
GO:0034080CENP-A containing nucleosome assembly-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045652regulation of megakaryocyte differentiation-TASProcess
GO:0045653negative regulation of megakaryocyte differentiation18474616.IDAProcess
GO:0045814negative regulation of gene expression, epigenetic-TASProcess
GO:0046982protein heterodimerization activity-IEAFunction
GO:0051290protein heterotetramerization20498094.IDAProcess
GO:0060964regulation of gene silencing by miRNA-TASProcess
GO:0070062extracellular exosome19199708.20458337.23533145.HDAComponent
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