EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.12220.11282
CESCDEL0.03390.01281
COADDEL0.12420.00038973
DLBCDEL0.04170.0017831
ESCAAMP0.34240.0022446
HNSCDEL0.11697.836e-19
KIRCAMP0.06820.059566
LUADDEL0.06782.5961e-13
LUSCAMP0.34131.6618e-06
PAADAMP0.2120.085665
PCPGAMP0.09880.00029562
READAMP0.20610.025154
SKCMAMP0.44419.6912e-06
STADDEL0.05440.0040659
TGCTAMP0.33330.088103

Survival Analysis
CancerP-value Q-value
ACC0.04

Kaplan-Meier Survival Analysis

HNSC0.046

Kaplan-Meier Survival Analysis

TGCT0.021

Kaplan-Meier Survival Analysis

COAD0.022

Kaplan-Meier Survival Analysis

PAAD0.028

Kaplan-Meier Survival Analysis

LIHC0.044

Kaplan-Meier Survival Analysis

LGG0.00039

Kaplan-Meier Survival Analysis

THCA0.037

Kaplan-Meier Survival Analysis

LUAD0.0046

Kaplan-Meier Survival Analysis

UVM0.016

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000270882 (Gene tree)
Gene ID
8370
Gene Symbol
HIST2H4A
Alias
H4F2|H4FN|HIST2H4|H4/n
Full Name
histone cluster 2 H4 family member a
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
7,111 bases
Position
chr1:149,832,657-149,839,767
Accession
4794
RBP type
non-canonical RBP
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000614272HIST2H4A-203942-ENSP00000478519103 (aa)-P62805
ENST00000578186HIST2H4A-201583-ENSP00000462667103 (aa)-P62805
ENST00000618193HIST2H4A-2041547-ENSP00000478786103 (aa)-P62805
ENST00000613412HIST2H4A-202610-ENSP00000481343103 (aa)-P62805
Gene Model
Click here to download ENSG00000270882's gene model file
Pathways
Pathway IDPathway NameSource
hsa05034AlcoholismKEGG
hsa05203Viral carcinogenesisKEGG
hsa05322Systemic lupus erythematosusKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000270882's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000270882HIST2H4A10099.029WBGene00001941his-6710099.029Caenorhabditis_elegans
ENSG00000270882HIST2H4A100100.000ENSG00000276180HIST1H4I100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000278705HIST1H4B100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000276966HIST1H4E100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000275126HIST1H4L100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000197061HIST1H4C100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000197837HIST4H4100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000274618HIST1H4F100100.000Homo_sapiens
ENSG00000270882HIST2H4A100100.000ENSG00000270276HIST2H4B100100.000Homo_sapiens
ENSG00000270882HIST2H4A10092.233YBR009C10092.233Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000183chromatin silencing at rDNA-TASProcess
GO:0000228nuclear chromosome14718166.IDAComponent
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000786nucleosome21636898.24699735.25615412.IDAComponent
GO:0000786nucleosome3035717.TASComponent
GO:0000788nuclear nucleosome20498094.IDAComponent
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding3035717.TASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus14585971.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006303double-strand break repair via nonhomologous end joining-TASProcess
GO:0006334nucleosome assembly21873635.IBAProcess
GO:0006334nucleosome assembly20498094.21636898.24699735.25615412.IDAProcess
GO:0006335DNA replication-dependent nucleosome assembly14718166.IDAProcess
GO:0006336DNA replication-independent nucleosome assembly14718166.IDAProcess
GO:0006352DNA-templated transcription, initiation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016233telomere capping-TASProcess
GO:0019904protein domain specific binding22368283.IPIFunction
GO:0032200telomere organization17675446.TASProcess
GO:0032991protein-containing complex14718166.IDAComponent
GO:0034080CENP-A containing nucleosome assembly-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045652regulation of megakaryocyte differentiation-TASProcess
GO:0045653negative regulation of megakaryocyte differentiation18474616.IDAProcess
GO:0045814negative regulation of gene expression, epigenetic-TASProcess
GO:0046982protein heterodimerization activity-IEAFunction
GO:0051290protein heterotetramerization20498094.IDAProcess
GO:0060964regulation of gene silencing by miRNA-TASProcess
GO:0070062extracellular exosome19199708.20458337.23533145.HDAComponent
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