EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26500060A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.Oncogene2016 Jun 16Nowicka AMdoi: 10.1038/onc.2015.400
17977820Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.J Biol Chem2008 Jan 4Palkowitsch L-
14764716The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.J Immunol2004 Feb 15Yang F-
21383699Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-??B: implication in breast cancer metastasis.Oncogene2011 Jul 14Bist Pdoi: 10.1038/onc.2011.28
28515148NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer.Cancer Res2017 Jul 15Elsarraj HSdoi: 10.1158/0008-5472.CAN-16-2794
27367027Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis.Oncotarget2016 Aug 2An Jdoi: 10.18632/oncotarget.10321.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchrX154552130Missense_MutationnovelS43L0.53
BLCAchrX154552144Missense_MutationnovelP48A0.43
COADchrX154558599Missense_MutationnovelS156I0.25
GBMchrX1545423745'Flanknovel0.3
GBMchrX154552043Missense_MutationnovelV14G0.1
KIRPchrX154562827SilentnovelD262D0.17
KIRPchrX1545424435'Flanknovel0.48
LGGchrX154552011SilentnovelR3R0.06
LUADchrX154552140SilentnovelG46G0.37
LUADchrX1545423905'Flanknovel0.33
LUADchrX154552052Missense_MutationnovelS17T0.07
LUSCchrX154558573SilentnovelT147T0.41
OVchrX1545423775'FlankNA0.14
OVchrX154552080SilentnovelV26V0.1
READchrX154562879Missense_MutationnovelV280M0.19
READchrX154558638Missense_MutationnovelA169D0.24
SKCMchrX154562951Nonsense_MutationnovelQ304*0.67
UCECchrX1545424125'Flankrs7822015260.33
UCECchrX154552180Nonsense_MutationnovelE60*0.56
UCECchrX154558607Missense_MutationnovelR159S0.19
UCECchrX154542283Missense_MutationnovelV7A0.24
UCECchrX154562934Missense_MutationnovelV298A0.27
UCECchrX154552177Nonsense_MutationnovelQ59*0.38
UCECchrX154556286SilentnovelL103L0.35
UCECchrX154556264Missense_MutationnovelK96T0.4
UCECchrX154562885Missense_MutationnovelD282N0.35
UCECchrX154562926Missense_MutationnovelM295I0.24
UCECchrX154552093Missense_MutationnovelS31T0.4
UCECchrX1545424355'Flanknovel0.31
UCECchrX154558567Missense_MutationnovelQ145H0.09
UCECchrX154552086Silentrs782455868G28G0.36
UCECchrX1545424355'Flanknovel0.3
UCECchrX154562885Missense_MutationnovelD282N0.2
UCECchrX1545423335'Flanknovel0.29
UCECchrX154552070Missense_MutationnovelD23A0.15
UCECchrX154558586Missense_MutationnovelE152K0.06
UCECchrX154552084Missense_MutationnovelG28C0.35
UCECchrX154552088Missense_MutationnovelE29A0.38
UCECchrX1545422515'UTRrs7823161000.2

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.19323.2002e-05
DLBCAMP0.14580.24013
HNSCAMP0.20880.0095371
KIRCAMP0.04360.12739
LIHCAMP0.15140.011319
LUADAMP0.21511.4252e-08
LUSCAMP0.17960.08275
OVAMP0.31432.176e-06
PAADAMP0.07610.041079
READAMP0.15760.14805
STADAMP0.11340.0021069
TGCTDEL0.07330.08422
THCADEL0.0060.21991
UCSDEL0.30360.063955

Survival Analysis
CancerP-value Q-value
STAD0.022

Kaplan-Meier Survival Analysis

SARC0.01

Kaplan-Meier Survival Analysis

ACC0.022

Kaplan-Meier Survival Analysis

UCS0.041

Kaplan-Meier Survival Analysis

SKCM0.05

Kaplan-Meier Survival Analysis

LUSC0.047

Kaplan-Meier Survival Analysis

PAAD0.027

Kaplan-Meier Survival Analysis

CESC0.011

Kaplan-Meier Survival Analysis

LAML0.005

Kaplan-Meier Survival Analysis

UCEC0.0048

Kaplan-Meier Survival Analysis

LGG0.0044

Kaplan-Meier Survival Analysis

UVM0.0023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000269335 (Gene tree)
Gene ID
8517
Gene Symbol
IKBKG
Alias
IKK-gamma|NEMO|Fip3p|FIP-3|FIP3|ZC2HC9|IP2|IP1
Full Name
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
27,375 bases
Position
chrX:154,541,199-154,568,573
Accession
5961
RBP type
non-canonical RBP
Summary
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25586786Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency.Hum Reprod2015 MarLeng Ldoi: 10.1093/humrep/deu358
11160844The NF-kappaB pathway in human endometrium and first trimester decidua.Mol Hum Reprod2001 FebKing AE-
23028469NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.PLoS One2012Wang Ldoi: 10.1371/journal.pone.0043756
18481966Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis.Biochem Soc Trans2008 JunSimon GCdoi: 10.1042/BST0360391.
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000612051IKBKG-2091972-ENSP0000048043148 (aa)-A0A087WWQ9
ENST00000445622IKBKG-204693-ENSP00000395205138 (aa)-C9JCG6
ENST00000618670IKBKG-2142069-ENSP00000483825487 (aa)-Q9Y6K9
ENST00000619941IKBKG-2151463-ENSP00000478979412 (aa)-A0A087WUW6
ENST00000615186IKBKG-210488-ENSP00000479144115 (aa)-A0A087WV30
ENST00000611176IKBKG-2081654-ENSP00000478616320 (aa)-Q9Y6K9
ENST00000611071IKBKG-2072103-ENSP00000479662419 (aa)-Q9Y6K9
ENST00000617207IKBKG-2121949-ENSP00000484023418 (aa)-A0A087X1B1
ENST00000413620IKBKG-201892-ENSP00000398579195 (aa)-C9J2V2
ENST00000594239IKBKG-2062299-ENSP00000471166419 (aa)-Q9Y6K9
ENST00000615874IKBKG-2111460-ENSP00000483381411 (aa)-A0A087X0G7
ENST00000440286IKBKG-203960-ENSP00000394934250 (aa)-C9JN51
ENST00000617838IKBKG-213285--- (aa)--
ENST00000422680IKBKG-202841-ENSP00000390368172 (aa)-C9JH59
ENST00000492469IKBKG-205552-ENSP00000484275181 (aa)-A0A087X1K7
Gene Model
Click here to download ENSG00000269335's gene model file
Pathways
Pathway IDPathway NameSource
hsa01523Antifolate resistanceKEGG
hsa04010MAPK signaling pathwayKEGG
hsa04014Ras signaling pathwayKEGG
hsa04062Chemokine signaling pathwayKEGG
hsa04064NF-kappa B signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04210ApoptosisKEGG
hsa04380Osteoclast differentiationKEGG
hsa04620Toll-like receptor signaling pathwayKEGG
hsa04621NOD-like receptor signaling pathwayKEGG
hsa04622RIG-I-like receptor signaling pathwayKEGG
hsa04623Cytosolic DNA-sensing pathwayKEGG
hsa04625C-type lectin receptor signaling pathwayKEGG
hsa04657IL-17 signaling pathwayKEGG
hsa04658Th1 and Th2 cell differentiationKEGG
hsa04659Th17 cell differentiationKEGG
hsa04660T cell receptor signaling pathwayKEGG
hsa04662B cell receptor signaling pathwayKEGG
hsa04668TNF signaling pathwayKEGG
hsa04920Adipocytokine signaling pathwayKEGG
hsa05120Epithelial cell signaling in Helicobacter pylori infectionKEGG
hsa05131ShigellosisKEGG
hsa05142Chagas disease (American trypanosomiasis)KEGG
hsa05145ToxoplasmosisKEGG
hsa05160Hepatitis CKEGG
hsa05161Hepatitis BKEGG
hsa05162MeaslesKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05164Influenza AKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
hsa05167Kaposi sarcoma-associated herpesvirus infectionKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
hsa05169Epstein-Barr virus infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05203Viral carcinogenesisKEGG
hsa05212Pancreatic cancerKEGG
hsa05215Prostate cancerKEGG
hsa05220Chronic myeloid leukemiaKEGG
hsa05221Acute myeloid leukemiaKEGG
hsa05222Small cell lung cancerKEGG
hsa05340Primary immunodeficiencyKEGG
hsa05418Fluid shear stress and atherosclerosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000269335Hemoglobin A, Glycosylated3E-1126366553
ENSG00000269335Hemoglobins3E-1126366553
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000269335's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000151ubiquitin ligase complex17314283.IPIComponent
GO:0000187activation of MAPK activity-TASProcess
GO:0000922spindle pole24561039.IDAComponent
GO:0002223stimulatory C-type lectin receptor signaling pathway-TASProcess
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-TASProcess
GO:0002756MyD88-independent toll-like receptor signaling pathway-TASProcess
GO:0005515protein binding9751060.11113112.11418127.11551959.12486103.14653779.14743216.15474016.15601829.15749833.16126728.16129692.16319058.16874300.16938294.17363905.17363973.17568778.17948050.18266467.18287044.18462684.18583959.19365808.19373254.19666608.19706536.19875381.20010814.20098747.20368414.20434986.20970423.21212807.21217772.21383699.21423167.21455180.21458669.21474709.21709223.21811235.21903422.21988832.23032186.23104095.24189400.24270572.24618592.25036637.25852190.25861989.26334375.26496610.27070702.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus14651848.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm11113112.14651848.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006915apoptotic process9927690.TASProcess
GO:0006954inflammatory response18626576.TASProcess
GO:0006955immune response9751060.TASProcess
GO:0006974cellular response to DNA damage stimulus14651848.IDAProcess
GO:0006974cellular response to DNA damage stimulus25861989.IMPProcess
GO:0007249I-kappaB kinase/NF-kappaB signaling18626576.TASProcess
GO:0007254JNK cascade-TASProcess
GO:0008385IkappaB kinase complex21873635.IBAComponent
GO:0008385IkappaB kinase complex23776175.IDAComponent
GO:0008385IkappaB kinase complex18626576.TASComponent
GO:0009615response to virus18626576.TASProcess
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TASProcess
GO:0016032viral process-IEAProcess
GO:0016239positive regulation of macroautophagy-ISSProcess
GO:0016579protein deubiquitination-TASProcess
GO:0019904protein domain specific binding15341735.IPIFunction
GO:0031625ubiquitin protein ligase binding23453807.IPIFunction
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TASProcess
GO:0038095Fc-epsilon receptor signaling pathway-TASProcess
GO:0042802identical protein binding18462684.21988832.IPIFunction
GO:0042803protein homodimerization activity23091055.IDAFunction
GO:0042975peroxisome proliferator activated receptor binding-IEAFunction
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling21873635.IBAProcess
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling17702576.IDAProcess
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-TASProcess
GO:0043276anoikis-ISSProcess
GO:0045087innate immune response18626576.TASProcess
GO:0045944positive regulation of transcription by RNA polymerase II23091055.IDAProcess
GO:0046872metal ion binding-IEAFunction
GO:0046982protein heterodimerization activity23091055.IDAFunction
GO:0050852T cell receptor signaling pathway15125833.NASProcess
GO:0050852T cell receptor signaling pathway-TASProcess
GO:0051092positive regulation of NF-kappaB transcription factor activity15620648.IDAProcess
GO:0051092positive regulation of NF-kappaB transcription factor activity18626576.TASProcess
GO:0051403stress-activated MAPK cascade-TASProcess
GO:0051650establishment of vesicle localization24561039.IMPProcess
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway-TASProcess
GO:0070498interleukin-1-mediated signaling pathway-TASProcess
GO:0070530K63-linked polyubiquitin modification-dependent protein binding21873635.IBAFunction
GO:0072686mitotic spindle24561039.IDAComponent
GO:1901215negative regulation of neuron death18221368.TASProcess
GO:1990450linear polyubiquitin binding23453807.IDAFunction
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