EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27485611	Analysis of RTEL1 and PCDHGB6 promoter methylation in circulating-free DNA of lung cancer patients using liquid biopsy: A pilot study.	Exp Lung Res	2016 Aug	Powrozek T	doi: 10.1080/01902148.2016.1214191
27765928	RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.	Oncotarget	2016 Oct 25	Yan S	doi: 10.18632/oncotarget.12297.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr20	63695896	3'UTR	novel		0.73
ACC	chr20	63672577	Missense_Mutation	novel	D241Y	0.27
ACC	chr20	63666066	Missense_Mutation	novel	G201R	0.45
ACC	chr20	63678320	Silent	rs755186853	D337D	0.36
BLCA	chr20	63689757	Missense_Mutation	novel	S678F	0.24
BLCA	chr20	63693198	Missense_Mutation	novel	I969M	0.15
BLCA	chr20	63695371	Silent	novel	I1181I	0.13
BLCA	chr20	63692966	Silent	rs757150825	L938L	0.24
BLCA	chr20	63693204	Silent	novel	L971L	0.45
BLCA	chr20	63667492	Missense_Mutation	rs770742969	R213Q	0.32
BLCA	chr20	63673995	Missense_Mutation	novel	S274L	0.2
BLCA	chr20	63692868	Missense_Mutation	NA	E906Q	0.08
BLCA	chr20	63687985	Missense_Mutation	novel	Q510H	0.39
BLCA	chr20	63692928	Missense_Mutation	rs369357121	D926N	0.27
BLCA	chr20	63693226	Missense_Mutation	rs144034326	R979W	0.09
BLCA	chr20	63678285	Missense_Mutation	novel	E326K	0.12
BLCA	chr20	63694936	Frame_Shift_Ins	novel	*T1103Afs87**	0.07
BRCA	chr20	63687956	Nonsense_Mutation	NA	E501*	0.16
BRCA	chr20	63694833	Missense_Mutation	rs762640318	R1068C	0.24
BRCA	chr20	63695782	Silent	novel	L1219L	0.07
BRCA	chr20	63661917	Silent	NA	I123I	0.21
BRCA	chr20	63690926	Silent	NA	A845A	0.36
BRCA	chr20	63695581	Intron	rs756080962		0.09
CESC	chr20	63661325	Missense_Mutation	novel	T44A	0.3	ResIII
CESC	chr20	63689542	Missense_Mutation	NA	G640V	0.27
CESC	chr20	63662841	Missense_Mutation	rs752046445	R164C	0.14
CESC	chr20	63689947	Intron	novel		0.26
CESC	chr20	63695210	Missense_Mutation	NA	A1163V	0.41
CESC	chr20	63694806	Missense_Mutation	rs115303435	A1059T	0.5
CESC	chr20	63689933	Intron	novel		0.75
CESC	chr20	63693255	Silent	novel	Q988Q	0.09
CESC	chr20	63693256	Silent	novel	R989R	0.08
CESC	chr20	63667523	Missense_Mutation	novel	F223L	0.59
CESC	chr20	63661938	Silent	NA	S130S	0.16
CESC	chr20	63690312	Missense_Mutation	rs750251447	R762W	0.2
CESC	chr20	63692984	Silent	rs147040733	K944K	0.36
CESC	chr20	63674044	Silent	rs200099775	A290A	0.36
CESC	chr20	63689635	Missense_Mutation	novel	G671E	0.28
CESC	chr20	63692890	Missense_Mutation	novel	A913V	0.43
CESC	chr20	63661385	Nonsense_Mutation	rs368311594	R64*	0.3
CESC	chr20	63688380	Missense_Mutation	NA	F572L	0.19
CESC	chr20	63659293	5'UTR	novel		0.31
CHOL	chr20	63690837	Silent	novel	L816L	0.09
COAD	chr20	63687684	Silent	rs376423914	H465H	0.4
COAD	chr20	63692928	Missense_Mutation	rs369357121	D926N	0.38
COAD	chr20	63695893	3'UTR	novel		0.29
COAD	chr20	63688052	Splice_Site	novel	X532_splice	0.06
COAD	chr20	63693222	Silent	novel	G977G	0.34
COAD	chr20	63687747	Silent	novel	S486S	0.25
COAD	chr20	63690367	Missense_Mutation	novel	P780L	0.15
COAD	chr20	63689801	Nonsense_Mutation	rs786205701	Q693*	0.26
COAD	chr20	63659432	Silent	rs746437645	T10T	0.38
COAD	chr20	63662843	Silent	NA	R164R	0.29
COAD	chr20	63687703	Missense_Mutation	novel	V472I	0.05
COAD	chr20	63659351	5'UTR	novel		0.46
COAD	chr20	63690013	Intron	novel		0.56
COAD	chr20	63695443	Silent	rs797045923	S1205S	0.28
COAD	chr20	63662844	Nonsense_Mutation	novel	K165*	0.09
COAD	chr20	63693258	Silent	novel	R989R	0.22
COAD	chr20	63690816	Missense_Mutation	NA	A809T	0.23
COAD	chr20	63690012	Intron	novel		0.35
COAD	chr20	63690079	Splice_Region	rs755965232		0.43
COAD	chr20	63693256	Missense_Mutation	rs139221232	R989W	0.36
COAD	chr20	63689563	Missense_Mutation	NA	P647L	0.45
COAD	chr20	63695534	Intron	rs200225613		0.15
COAD	chr20	63695825	3'UTR	rs765090741		0.08
COAD	chr20	63690349	Missense_Mutation	rs771721817	V774A	0.11
ESCA	chr20	63678315	Missense_Mutation	novel	G336R	0.16
ESCA	chr20	63694884	Missense_Mutation	novel	A1085S	0.41
GBM	chr20	63666031	Missense_Mutation	novel	S189N	0.23
GBM	chr20	63694776	Missense_Mutation	NA	V1049L	0.43
GBM	chr20	63689951	Intron	novel		0.36
GBM	chr20	63673986	Missense_Mutation	novel	D271V	0.3
GBM	chr20	63688534	Missense_Mutation	rs371161995	D577N	0.18
GBM	chr20	63659431	Missense_Mutation	novel	T10N	0.52
GBM	chr20	63685538	Missense_Mutation	NA	D403N	0.22
HNSC	chr20	63695125	Silent	novel	L1135L	0.42
HNSC	chr20	63667493	Silent	novel	R213R	0.29
HNSC	chr20	63690171	Silent	novel	I742I	0.08
HNSC	chr20	63690398	Missense_Mutation	rs553827008	K790N	0.1
HNSC	chr20	63695571	Intron	novel		0.16
HNSC	chr20	63695627	Intron	novel		0.67
HNSC	chr20	63694849	Missense_Mutation	novel	S1073F	0.14
HNSC	chr20	63666032	Missense_Mutation	novel	S189R	0.22
KIRC	chr20	63692807	Splice_Region	novel	E885E	0.27
KIRP	chr20	63690922	Missense_Mutation	rs758245234	R844Q	0.38
LGG	chr20	63672565	Missense_Mutation	novel	A237T	0.5
LIHC	chr20	63692834	Silent	rs535831345	D894D	0.51
LIHC	chr20	63685560	Frame_Shift_Del	novel	*S411Gfs38**	0.19
LUAD	chr20	63661440	Missense_Mutation	rs143461704	P82L	0.27
LUAD	chr20	63667529	Silent	rs762854518	P225P	0.07
LUAD	chr20	63685538	Missense_Mutation	NA	D403N	0.16
LUAD	chr20	63688353	Frame_Shift_Del	novel	*P564Cfs101**	0.07
LUAD	chr20	63690825	Missense_Mutation	novel	P812S	0.44
LUAD	chr20	63690431	Missense_Mutation	NA	Q801H	0.32
LUAD	chr20	63687973	Silent	rs757231662	I506I	0.18
LUAD	chr20	63661342	Silent	NA	T49T	0.2
LUAD	chr20	63685549	Missense_Mutation	NA	E406D	0.37
LUAD	chr20	63692955	Missense_Mutation	rs769930889	L935F	0.08
LUAD	chr20	63690377	Missense_Mutation	novel	F783L	0.2
LUAD	chr20	63685843	Missense_Mutation	NA	A440V	0.24
LUSC	chr20	63689809	Silent	rs774642602	I695I	0.29
LUSC	chr20	63690422	Missense_Mutation	novel	S798R	0.11
LUSC	chr20	63688148	Silent	rs114292675	E535E	0.19
LUSC	chr20	63695083	Missense_Mutation	novel	R1121S	0.15
LUSC	chr20	63688166	Silent	novel	L541L	0.08
LUSC	chr20	63690924	Missense_Mutation	NA	A845S	0.36
LUSC	chr20	63687718	Missense_Mutation	NA	L477F	0.46
LUSC	chr20	63661384	Silent	novel	L63L	0.14
LUSC	chr20	63661914	Silent	novel	V122V	0.09
LUSC	chr20	63695371	Silent	NA	I1181I	0.05
LUSC	chr20	63661381	Silent	novel	H62H	0.23
LUSC	chr20	63691821	Missense_Mutation	rs770539835	R879P	0.11
LUSC	chr20	63695110	Missense_Mutation	novel	Q1130K	0.11
LUSC	chr20	63689765	Nonsense_Mutation	novel	E681*	0.18
LUSC	chr20	63692828	Silent	novel	Q892Q	0.16
LUSC	chr20	63689945	Intron	novel		0.24
LUSC	chr20	63695160	Silent	novel	P1146P	0.34
MESO	chr20	63695826	3'UTR	rs544271988		0.78
OV	chr20	63687717	Missense_Mutation	NA	I476M	0.23
OV	chr20	63694441	Missense_Mutation	NA	H1021L	0.13
OV	chr20	63674061	Missense_Mutation	novel	H296R	0.16
PAAD	chr20	63690441	Missense_Mutation	novel	G805R	0.17
PRAD	chr20	63689983	Intron	novel		0.29
PRAD	chr20	63692880	Missense_Mutation	novel	A910S	0.34
PRAD	chr20	63689966	Intron	novel		0.24
READ	chr20	63661911	Missense_Mutation	NA	Q121H	0.21
READ	chr20	63667529	Silent	rs762854518	P225P	0.29
READ	chr20	63693235	Missense_Mutation	NA	H982D	0.22
READ	chr20	63690915	Missense_Mutation	novel	E842K	0.13
SARC	chr20	63695824	3'UTR	novel		0.09
SARC	chr20	63695388	Missense_Mutation	novel	Q1187R	0.21
SARC	chr20	63689620	Missense_Mutation	novel	M666R	0.15
SARC	chr20	63689955	Intron	novel		0.46
SARC	chr20	63662860	Missense_Mutation	rs750794827	R170H	0.41
SKCM	chr20	63661402	Silent	NA	A69A	0.39
SKCM	chr20	63689809	Silent	rs774642602	I695I	0.3
SKCM	chr20	63693266	Missense_Mutation	rs143967591	P992L	0.21
SKCM	chr20	63659408	Silent	novel	P2P	0.41
SKCM	chr20	63692939	Silent	rs115030322	A929A	0.34
SKCM	chr20	63689924	Intron	novel		0.21
SKCM	chr20	63689925	Intron	novel		0.21
SKCM	chr20	63690090	Silent	rs762607146	F715F	0.1
SKCM	chr20	63691784	Missense_Mutation	novel	P867S	0.25
SKCM	chr20	63661402	Silent	NA	A69A	0.38
SKCM	chr20	63661403	Missense_Mutation	rs778775766	R70C	0.38
SKCM	chr20	63662592	Missense_Mutation	novel	P148S	0.57
SKCM	chr20	63662593	Missense_Mutation	novel	P148L	0.56
SKCM	chr20	63690018	Intron	novel		0.16
SKCM	chr20	63693198	Silent	NA	I969I	0.1
SKCM	chr20	63661413	Missense_Mutation	novel	A73V	0.33
SKCM	chr20	63661414	Silent	rs781340943	A73A	0.34
SKCM	chr20	63689052	Splice_Region	novel		0.09
SKCM	chr20	63690030	Intron	novel		0.4
SKCM	chr20	63667490	Silent	NA	S212S	0.12
SKCM	chr20	63695498	Intron	NA		0.29
SKCM	chr20	63695198	Missense_Mutation	NA	L1159P	0.24
SKCM	chr20	63693147	Silent	NA	F952F	0.43
SKCM	chr20	63667475	Silent	NA	C207C	0.15
SKCM	chr20	63690184	Nonsense_Mutation	novel	Q747*	0.15
SKCM	chr20	63690090	Silent	rs762607146	F715F	0.48
SKCM	chr20	63685545	Missense_Mutation	rs375916694	S405F	0.32
SKCM	chr20	63661439	Missense_Mutation	NA	P82S	0.21
SKCM	chr20	63685546	Silent	rs368407107	S405S	0.33
SKCM	chr20	63695369	Missense_Mutation	rs376148207	I1181V	0.22
STAD	chr20	63690079	Splice_Region	rs755965232		0.29
STAD	chr20	63692958	Missense_Mutation	rs749800565	G936S	0.2
STAD	chr20	63661899	Silent	novel	S117S	0.09
STAD	chr20	63694805	Silent	rs146247083	H1058H	0.44
STAD	chr20	63662860	Missense_Mutation	rs750794827	R170H	0.2
STAD	chr20	63689779	Silent	NA	Q685Q	0.37
STAD	chr20	63690079	Splice_Region	rs755965232		0.27
STAD	chr20	63693174	Silent	NA	K961K	0.29
STAD	chr20	63694901	Missense_Mutation	novel	D1090E	0.1
STAD	chr20	63689566	Frame_Shift_Ins	novel	*R651Tfs15**	0.23
STAD	chr20	63661446	Missense_Mutation	rs201555555	R84Q	0.2
STAD	chr20	63689784	Missense_Mutation	NA	A687V	0.3
STAD	chr20	63694898	Silent	rs370637234	D1089D	0.09
STAD	chr20	63679914	Missense_Mutation	rs765792997	S368L	0.22
STAD	chr20	63690079	Splice_Region	rs755965232		0.35
STAD	chr20	63694806	Missense_Mutation	rs115303435	A1059T	0.28
STAD	chr20	63690079	Splice_Region	rs755965232		0.21
STAD	chr20	63661441	Silent	rs775247678	P82P	0.24
STAD	chr20	63693248	Missense_Mutation	rs146221660	R986Q	0.28
STAD	chr20	63687936	Splice_Site	NA	X494_splice	0.22
UCEC	chr20	63687958	Missense_Mutation	NA	E501D	0.33
UCEC	chr20	63685870	Missense_Mutation	rs779873020	R449Q	0.5
UCEC	chr20	63661363	Silent	rs776722400	T56T	0.47
UCEC	chr20	63662571	Missense_Mutation	rs746931551	R141W	0.3
UCEC	chr20	63662860	Missense_Mutation	rs750794827	R170H	0.35
UCEC	chr20	63695898	3'UTR	novel		0.13
UCEC	chr20	63678182	Missense_Mutation	NA	K319N	0.43
UCEC	chr20	63695451	Missense_Mutation	novel	P1208H	0.06
UCEC	chr20	63662418	Intron	NA		0.29
UCEC	chr20	63695428	Silent	novel	A1200A	0.21
UCEC	chr20	63687974	Missense_Mutation	rs778782744	D507N	0.49
UCEC	chr20	63667534	Missense_Mutation	rs774126648	N227S	0.47
UCEC	chr20	63661341	Missense_Mutation	novel	T49M	0.4	ResIII
UCEC	chr20	63662412	Intron	novel		0.42
UCEC	chr20	63662853	Missense_Mutation	rs762279135	A168T	0.5
UCEC	chr20	63693144	Splice_Region	novel	G951G	0.47
UCEC	chr20	63695928	3'UTR	novel		0.36
UCEC	chr20	63674077	Silent	rs377191081	A301A	0.25
UCEC	chr20	63689842	Silent	novel	G706G	0.14
UCEC	chr20	63662841	Missense_Mutation	rs752046445	R164C	0.16
UCEC	chr20	63690163	Missense_Mutation	novel	H740N	0.11
UCEC	chr20	63659289	5'UTR	novel		0.32
UCEC	chr20	63662517	Intron	NA		0.51
UCEC	chr20	63689531	Silent	novel	T636T	0.32
UCEC	chr20	63659432	Silent	novel	T10T	0.26
UCEC	chr20	63691831	Missense_Mutation	novel	S882R	0.35
UCEC	chr20	63659351	5'UTR	novel		0.39
UCEC	chr20	63662479	Intron	rs763297385		0.34
UCEC	chr20	63689925	Intron	novel		0.29
UCEC	chr20	63690152	Missense_Mutation	novel	D736A	0.38
UCEC	chr20	63695826	3'UTR	rs544271988		0.41
UCEC	chr20	63662882	Silent	rs781051899	N177N	0.27
UCEC	chr20	63661871	Missense_Mutation	novel	K108T	0.32
UCEC	chr20	63693281	Missense_Mutation	novel	T997I	0.23
UCEC	chr20	63694814	Silent	rs573260461	S1061S	0.26
UCEC	chr20	63695114	Missense_Mutation	rs372852392	T1131M	0.45
UCEC	chr20	63662882	Silent	rs781051899	N177N	0.29
UCEC	chr20	63678184	Splice_Site	novel	X320_splice	0.09
UCEC	chr20	63687701	Missense_Mutation	novel	G471D	0.17
UCEC	chr20	63659352	5'UTR	rs548912361		0.31
UCEC	chr20	63688016	Missense_Mutation	rs774688252	D521N	0.43
UCEC	chr20	63688534	Missense_Mutation	rs371161995	D577N	0.38
UCEC	chr20	63692940	Missense_Mutation	rs371721039	A930T	0.31
UCEC	chr20	63694388	Missense_Mutation	novel	D1003E	0.43
UCEC	chr20	63661494	Missense_Mutation	novel	I100T	0.16
UCEC	chr20	63691786	Silent	rs201545339	P867P	0.3
UCEC	chr20	63695581	Intron	rs756080962		0.25
UCEC	chr20	63679874	Missense_Mutation	novel	A355S	0.33
UCEC	chr20	63694854	Missense_Mutation	novel	G1075S	0.44
UCEC	chr20	63690336	Missense_Mutation	rs537754916	G770R	0.3
UCEC	chr20	63688534	Missense_Mutation	rs371161995	D577N	0.12
UCEC	chr20	63693242	Missense_Mutation	novel	I984T	0.43
UCEC	chr20	63695549	Intron	novel		0.37
UCEC	chr20	63661444	Silent	novel	D83D	0.38
UCEC	chr20	63694418	Silent	novel	A1013A	0.18
UCEC	chr20	63695393	Missense_Mutation	novel	P1189S	0.28
UCEC	chr20	63673955	Nonsense_Mutation	NA	E261*	0.36
UCEC	chr20	63693201	Silent	NA	Q970Q	0.15
UCEC	chr20	63695368	Missense_Mutation	NA	K1180N	0.24
UCEC	chr20	63661928	Missense_Mutation	rs769163032	R127Q	0.25
UCEC	chr20	63659362	5'UTR	novel		0.24
UCEC	chr20	63689546	Silent	novel	V641V	0.14
UCEC	chr20	63662512	Intron	novel		0.51
UCEC	chr20	63695429	Missense_Mutation	novel	G1201S	0.41
UCEC	chr20	63690079	Splice_Region	rs755965232		0.33
UCEC	chr20	63674065	Silent	rs771117146	P297P	0.17
UCEC	chr20	63688357	Missense_Mutation	novel	V565I	0.34
UCEC	chr20	63690353	Silent	rs138950475	S775S	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	AMP	0.2892	0.013414
LUAD	AMP	0.3702	8.1427e-15
OV	AMP	0.6321	5.6628e-10
PRAD	AMP	0.0589	0.07085
READ	AMP	0.8667	0.033971
SARC	AMP	0.3074	0.033553
SKCM	AMP	0.4496	0.058021

Survival Analysis

Cancer	P-value	Q-value
SARC	0.035	Kaplan-Meier Survival Analysis
MESO	0.033	Kaplan-Meier Survival Analysis
HNSC	0.022	Kaplan-Meier Survival Analysis
PRAD	0.031	Kaplan-Meier Survival Analysis
LUSC	0.021	Kaplan-Meier Survival Analysis
ESCA	0.047	Kaplan-Meier Survival Analysis
PCPG	0.035	Kaplan-Meier Survival Analysis
CESC	0.014	Kaplan-Meier Survival Analysis
READ	0.038	Kaplan-Meier Survival Analysis
LGG	0.00024	Kaplan-Meier Survival Analysis
LUAD	0.0057	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000258366 (Gene tree)
Gene ID: 51750
Gene Symbol: RTEL1
Alias: bK3184A7.3|NHL|DKFZP434C013|KIAA1088|RTEL|C20orf41
Full Name: regulator of telomere elongation helicase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 38,444 bases
Position: chr20:63,657,810-63,696,253
Accession: 15888
RBP type: canonical RBP
Summary: This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000494280	ResIII	PF04851.15	4e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370018	RTEL1-205	4955	-	ENSP00000359035	1219 (aa)	-	Q9NZ71
ENST00000647249	RTEL1-215	457	-	-	- (aa)	-	-
ENST00000645309	RTEL1-213	331	-	-	- (aa)	-	-
ENST00000360203	RTEL1-203	4630	-	ENSP00000353332	1300 (aa)	-	Q9NZ71
ENST00000370003	RTEL1-204	2273	-	-	- (aa)	-	-
ENST00000496816	RTEL1-211	2222	-	ENSP00000425576	316 (aa)	-	A0A0C4DGC7
ENST00000488316	RTEL1-210	669	-	-	- (aa)	-	-
ENST00000508582	RTEL1-212	4273	-	ENSP00000424307	1243 (aa)	-	Q9NZ71
ENST00000646389	RTEL1-214	570	-	ENSP00000494280	89 (aa)	-	A0A2R8YD56
ENST00000469728	RTEL1-208	601	-	ENSP00000496027	48 (aa)	-	A0A2R8Y7H5
ENST00000318100	RTEL1-201	4162	-	ENSP00000322287	996 (aa)	-	Q9NZ71
ENST00000482936	RTEL1-209	3474	-	ENSP00000457868	1004 (aa)	-	Q9NZ71
ENST00000463361	RTEL1-207	575	-	-	- (aa)	-	-
ENST00000425905	RTEL1-206	664	-	ENSP00000388063	221 (aa)	-	X6RBZ7
ENST00000356810	RTEL1-202	1339	-	ENSP00000349265	356 (aa)	-	X6R5I7

Gene Model

Click here to download ENSG00000258366's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000258366	Smoking	8.7600000E-006	-
ENSG00000258366	Platelet Function Tests	2.3900000E-007	-
ENSG00000258366	Platelet Function Tests	8.7400000E-006	-
ENSG00000258366	Glioma	1.4930000E-007	-
ENSG00000258366	Glioma	1.1290000E-010	-
ENSG00000258366	Glioma	3.8930000E-010	-
ENSG00000258366	Glioma	9E-11	26424050
ENSG00000258366	Dermatitis, Atopic	2E-9	26482879
ENSG00000258366	Colitis, Ulcerative	2E-10	21297633
ENSG00000258366	Glioma	2E-9	21531791
ENSG00000258366	Dental Caries	3E-6	23259602
ENSG00000258366	Glioma	5E-19	24908248
ENSG00000258366	Dermatitis, Atopic	7E-13	26482879
ENSG00000258366	Glioblastoma	1E-13	26424050
ENSG00000258366	Glioma	2E-9	19578366
ENSG00000258366	Glioma	3E-9	19578366
ENSG00000258366	Glioma	3E-12	19578367
ENSG00000258366	Glioma	1E-10	22886559

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000258366	rs2297439	20	63679775	G	Telomere length	29151059	[0.081-0.159] unit decrease	0.12	EFO_0004505
ENSG00000258366	rs2297440	20	63680946	C	Non-glioblastoma glioma	29743610	[1.17-1.43]	1.29	EFO_0005543
ENSG00000258366	rs2297440	20	63680946	C	Glioblastoma	29743610	[1.35-1.59]	1.47	EFO_0005543
ENSG00000258366	rs2297440	20	63680946	C	Glioblastoma	29743610	[1.39-1.70]	1.53	EFO_0005543
ENSG00000258366	rs2297440	20	63680946	C	Glioma	29743610	[1.32-1.52]	1.42	EFO_0005543
ENSG00000258366	rs2297440	20	63680946	C	Glioma	29743610	[1.26-1.49]	1.37	EFO_0005543
ENSG00000258366	rs6010620	20	63678486	G	Atopic dermatitis	26482879	[1.06-1.13]	1.09	EFO_0000274
ENSG00000258366	rs4809219	20	63671762	A	Atopic dermatitis	26482879		1.1111112	EFO_0000274
ENSG00000258366	rs2236507	20	63691653	C	Glioma	26424050	[1.18-1.35]	1.2658228	EFO_0000326
ENSG00000258366	rs6062302	20	63689615	C	Glioblastoma	26424050	[1.3-1.56]	1.4285715	EFO_0000519
ENSG00000258366	rs6011002	20	63666449	?	Dental caries	23259602			EFO_0003819
ENSG00000258366	rs6010620	20	63678486	G	Glioma	22886559	[1.28-1.59]	1.43	EFO_0000326
ENSG00000258366	rs6010620	20	63678486	G	Glioma (high-grade)	24908248	[1.42-1.72]	1.56	EFO_0000326
ENSG00000258366	rs6010620	20	63678486	G	Glioma	19578367	[1.21-1.35]	1.28	EFO_0000326
ENSG00000258366	rs6010620	20	63678486	G	Glioma (high-grade)	19578366	[1.32-1.75]	1.52	EFO_0000326
ENSG00000258366	rs4809324	20	63686867	C	Glioma (high-grade)	19578366	[1.37-1.87]	1.6	EFO_0000326
ENSG00000258366	rs2297440	20	63680946	C	Glioma	28346443	1.30-1.42	1.36	EFO_0000326\|EFO_0005543
ENSG00000258366	rs2297440	20	63680946	C	Glioblastoma	28346443	1.40-1.56	1.48	EFO_0000326\|EFO_0000519
ENSG00000258366	rs2297440	20	63680946	C	Non-glioblastoma glioma	28346443	1.13-1.26	1.2	EFO_0000326\|EFO_0005543
ENSG00000258366	rs3787096	20	63676805	G	Plateletcrit	27863252	[0.018-0.032] unit increase	0.02508724	EFO_0007985
ENSG00000258366	rs2297441	20	63696229	A	Ulcerative colitis	21297633	[1.04-1.15]	1.09	EFO_0000729
ENSG00000258366	rs6010620	20	63678486	?	Glioma	21531791	[NR]	1.24	EFO_0000326
ENSG00000258366	rs6011033	20	63691346	?	Respiratory diseases	30595370			EFO_0000684
ENSG00000258366	rs2297440	20	63680946	C	Glioblastoma (age-stratified)	30152087	[1.32-1.60]	1.45	EFO_0004847\|EFO_0000519
ENSG00000258366	rs2297440	20	63680946	C	Glioblastoma (age-stratified)	30152087	[1.28-1.55]	1.41	EFO_0004847\|EFO_0000519
ENSG00000258366	rs2297440	20	63680946	C	Glioblastoma (age-stratified)	30152087	[1.40-1.70]	1.55	EFO_0004847\|EFO_0000519
ENSG00000258366	rs6062302	20	63689615	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000258366	rs35640778	20	63689775	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000258366	rs3208007	20	63690935	?	Asthma or allergic disease (pleiotropy)	29785011		1.0526316	EFO_0003785\|EFO_0000270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000258366's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000258366	RTEL1	100	91.011	ENSAMEG00000001689	-	100	76.161	Ailuropoda_melanoleuca
ENSG00000258366	RTEL1	87	39.726	ENSCJAG00000001292	BRIP1	61	42.322	Callithrix_jacchus
ENSG00000258366	RTEL1	100	85.393	ENSCAFG00020001919	-	100	74.905	Canis_lupus_dingo
ENSG00000258366	RTEL1	87	41.096	ENSCCAG00000024685	BRIP1	60	41.096	Cebus_capucinus
ENSG00000258366	RTEL1	100	94.382	ENSCATG00000013982	-	100	93.415	Cercocebus_atys
ENSG00000258366	RTEL1	85	39.437	ENSCATG00000041725	BRIP1	58	42.623	Cercocebus_atys
ENSG00000258366	RTEL1	100	91.011	ENSCLAG00000005519	-	98	77.983	Chinchilla_lanigera
ENSG00000258366	RTEL1	87	36.986	ENSCSAG00000005928	BRIP1	58	36.986	Chlorocebus_sabaeus
ENSG00000258366	RTEL1	96	40.462	ENSCING00000019781	-	100	43.465	Ciona_intestinalis
ENSG00000258366	RTEL1	96	42.899	ENSCSAVG00000002028	-	99	43.065	Ciona_savignyi
ENSG00000258366	RTEL1	87	36.986	ENSCANG00000032026	BRIP1	52	40.314	Colobus_angolensis_palliatus
ENSG00000258366	RTEL1	100	87.640	ENSDORG00000013483	Rtel1	98	77.854	Dipodomys_ordii
ENSG00000258366	RTEL1	100	93.258	ENSEASG00005023163	-	99	81.818	Equus_asinus_asinus
ENSG00000258366	RTEL1	100	92.135	ENSECAG00000021707	-	99	83.244	Equus_caballus
ENSG00000258366	RTEL1	82	43.103	ENSECAG00000024392	BRIP1	63	39.362	Equus_caballus
ENSG00000258366	RTEL1	100	76.404	ENSGGOG00000042405	RTEL1	98	72.504	Gorilla_gorilla
ENSG00000258366	RTEL1	100	89.888	ENSHGLG00000005511	-	100	74.635	Heterocephalus_glaber_female
ENSG00000258366	RTEL1	100	89.888	ENSHGLG00100002438	-	100	74.579	Heterocephalus_glaber_male
ENSG00000258366	RTEL1	100	88.764	ENSLAFG00000021665	-	99	67.854	Loxodonta_africana
ENSG00000258366	RTEL1	99	95.721	ENSMFAG00000043680	-	100	94.717	Macaca_fascicularis
ENSG00000258366	RTEL1	85	40.845	ENSMFAG00000044136	BRIP1	58	40.845	Macaca_fascicularis
ENSG00000258366	RTEL1	100	94.382	ENSMMUG00000000167	-	100	90.238	Macaca_mulatta
ENSG00000258366	RTEL1	85	40.845	ENSMNEG00000040728	BRIP1	80	40.845	Macaca_nemestrina
ENSG00000258366	RTEL1	85	39.437	ENSMLEG00000037601	BRIP1	57	42.623	Mandrillus_leucophaeus
ENSG00000258366	RTEL1	97	82.558	MGP_CAROLIEiJ_G0024804	Rtel1	100	85.802	Mus_caroli
ENSG00000258366	RTEL1	97	82.558	ENSMUSG00000038685	Rtel1	100	85.802	Mus_musculus
ENSG00000258366	RTEL1	100	84.270	MGP_PahariEiJ_G0026252	Rtel1	100	86.420	Mus_pahari
ENSG00000258366	RTEL1	97	82.558	MGP_SPRETEiJ_G0025730	Rtel1	100	85.802	Mus_spretus
ENSG00000258366	RTEL1	99	73.541	ENSPPAG00000033509	-	98	73.541	Pan_paniscus
ENSG00000258366	RTEL1	97	81.395	ENSPTRG00000048787	-	99	78.022	Pan_troglodytes
ENSG00000258366	RTEL1	100	94.793	ENSPANG00000020635	-	100	94.793	Papio_anubis
ENSG00000258366	RTEL1	85	39.437	ENSPANG00000022169	BRIP1	57	42.623	Papio_anubis
ENSG00000258366	RTEL1	99	48.747	ENSPMAG00000008098	-	100	53.723	Petromyzon_marinus
ENSG00000258366	RTEL1	100	84.444	ENSPCIG00000017939	-	99	56.408	Phascolarctos_cinereus
ENSG00000258366	RTEL1	100	93.258	ENSPCOG00000013374	-	100	81.895	Propithecus_coquereli
ENSG00000258366	RTEL1	100	86.517	ENSRNOG00000027513	Rtel1	100	73.813	Rattus_norvegicus
ENSG00000258366	RTEL1	100	94.398	ENSRROG00000038795	-	100	94.462	Rhinopithecus_roxellana
ENSG00000258366	RTEL1	87	38.356	ENSSBOG00000035665	BRIP1	57	41.361	Saimiri_boliviensis_boliviensis
ENSG00000258366	RTEL1	100	91.011	ENSUAMG00000009334	-	95	81.361	Ursus_americanus
ENSG00000258366	RTEL1	100	91.011	ENSUMAG00000022059	-	99	74.074	Ursus_maritimus
ENSG00000258366	RTEL1	100	85.393	ENSVVUG00000015049	-	96	76.024	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	23453664.	IMP	Process
GO:0000723	telomere maintenance	-	ISS	Process
GO:0000732	strand displacement	-	ISS	Process
GO:0000732	strand displacement	-	TAS	Process
GO:0000781	chromosome, telomeric region	-	ISS	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	18957201.	IMP	Function
GO:0004003	ATP-dependent DNA helicase activity	24115439.	ISS	Function
GO:0004003	ATP-dependent DNA helicase activity	-	TAS	Function
GO:0005515	protein binding	23585563.23959892.25620558.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	18957201.	IMP	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	23585563.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0010569	regulation of double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0010569	regulation of double-strand break repair via homologous recombination	18957201.	IMP	Process
GO:0031297	replication fork processing	24115439.	ISS	Process
GO:0032206	positive regulation of telomere maintenance	-	ISS	Process
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0032508	DNA duplex unwinding	24115439.	ISS	Process
GO:0043247	telomere maintenance in response to DNA damage	-	ISS	Process
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process
GO:0045910	negative regulation of DNA recombination	-	ISS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	Function
GO:0070182	DNA polymerase binding	21873635.	IBA	Function
GO:0090657	telomeric loop disassembly	21873635.	IBA	Process
GO:0090657	telomeric loop disassembly	25620558.	IMP	Process
GO:0090657	telomeric loop disassembly	-	ISS	Process
GO:1902990	mitotic telomere maintenance via semi-conservative replication	24115439.	ISS	Process
GO:1904355	positive regulation of telomere capping	23959892.	IMP	Process
GO:1904358	positive regulation of telomere maintenance via telomere lengthening	23959892.	IMP	Process
GO:1904430	negative regulation of t-circle formation	21873635.	IBA	Process
GO:1904430	negative regulation of t-circle formation	25620558.	IMP	Process
GO:1904430	negative regulation of t-circle formation	24115439.	ISS	Process
GO:1904430	negative regulation of t-circle formation	24115439.	TAS	Process
GO:1904506	negative regulation of telomere maintenance in response to DNA damage	-	ISS	Process
GO:1904535	positive regulation of telomeric loop disassembly	-	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.