EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr4	134201233	5'UTR	novel		0.42
BRCA	chr4	134200229	Missense_Mutation	novel	R264Q	0.08
BRCA	chr4	134200496	Missense_Mutation	NA	R175Q	0.16
BRCA	chr4	134200855	Nonsense_Mutation	NA	Y55*	0.13
BRCA	chr4	134201095	5'UTR	novel		0.35
BRCA	chr4	134200488	Missense_Mutation	NA	R178C	0.36
BRCA	chr4	134200711	Missense_Mutation	NA	K103N	0.13
BRCA	chr4	134200560	Missense_Mutation	novel	I154F	0.13
BRCA	chr4	134200744	Silent	NA	L92L	0.31
CESC	chr4	134200930	Silent	novel	F30F	0.4
CESC	chr4	134199895	3'UTR	novel		0.63
CESC	chr4	134200086	Missense_Mutation	NA	E312K	0.2	RRM_5
CESC	chr4	134200038	Missense_Mutation	novel	E328Q	0.42	RRM_5
COAD	chr4	134201233	5'UTR	novel		0.3
COAD	chr4	134200107	Missense_Mutation	NA	D305N	0.23	RRM_5
COAD	chr4	134200230	Missense_Mutation	novel	R264W	0.27
COAD	chr4	134200091	Missense_Mutation	novel	R310Q	0.32	RRM_5
COAD	chr4	134200555	Silent	novel	E155E	0.41
COAD	chr4	134200158	Missense_Mutation	novel	R288C	0.34
COAD	chr4	134200496	Missense_Mutation	NA	R175Q	0.33
COAD	chr4	134200756	Silent	rs746989490	R88R	0.38
COAD	chr4	134201125	5'UTR	rs757042492		0.17
COAD	chr4	134200350	Missense_Mutation	NA	D224Y	0.24
COAD	chr4	134200759	Silent	NA	Q87Q	0.56
COAD	chr4	134200997	Missense_Mutation	rs369585514	R8H	0.3
COAD	chr4	134200368	Missense_Mutation	novel	S218C	0.22
COAD	chr4	134200406	Missense_Mutation	novel	R205I	0.31
COAD	chr4	134199995	Missense_Mutation	NA	P342H	0.08	RRM_5
COAD	chr4	134199956	Missense_Mutation	rs373992035	R355H	0.22	RRM_5
COAD	chr4	134200819	Silent	NA	A67A	0.36
COAD	chr4	134200775	Missense_Mutation	NA	R82H	0.32
COAD	chr4	134200164	Nonsense_Mutation	rs540190827	R286*	0.31
COAD	chr4	134200807	Missense_Mutation	novel	M71I	0.22
COAD	chr4	134201038	5'UTR	rs761517220		0.09
COAD	chr4	134201169	5'UTR	NA		0.25
COAD	chr4	134200528	Silent	NA	G164G	0.12
COAD	chr4	134200488	Missense_Mutation	NA	R178C	0.16
COAD	chr4	134200725	Missense_Mutation	NA	N99D	0.31
COAD	chr4	134200375	Missense_Mutation	novel	K215N	0.4
COAD	chr4	134200443	Missense_Mutation	NA	Y193H	0.41
COAD	chr4	134199919	Silent	novel	A367A	0.62
COAD	chr4	134200647	Missense_Mutation	novel	L125I	0.4
ESCA	chr4	134200937	Missense_Mutation	novel	R28M	0.67
ESCA	chr4	134200302	Missense_Mutation	novel	H240Y	0.24
HNSC	chr4	134200360	Missense_Mutation	novel	K220N	0.38
KIRC	chr4	134199919	Silent	rs779783392	A367A	0.21
KIRP	chr4	134199993	Nonsense_Mutation	NA	E343*	0.27	RRM_5
LIHC	chr4	134200379	Missense_Mutation	NA	G214V	0.44
LIHC	chr4	134200209	Nonsense_Mutation	rs779118612	R271*	0.18
LIHC	chr4	134200056	Missense_Mutation	rs756917832	V322F	0.27	RRM_5
LIHC	chr4	134200844	Nonsense_Mutation	NA	L59*	0.46
LIHC	chr4	134200154	Missense_Mutation	novel	G289V	0.1
LIHC	chr4	134201205	5'UTR	novel		0.39
LIHC	chr4	134199943	Silent	novel	S359S	0.3
LUSC	chr4	134200901	Missense_Mutation	novel	R40L	0.43
READ	chr4	134201076	5'UTR	NA		0.23
READ	chr4	134201154	5'UTR	NA		0.29
SARC	chr4	134199947	Missense_Mutation	novel	G358V	0.42	RRM_5
SARC	chr4	134199865	3'UTR	novel		0.31
SARC	chr4	134201054	5'UTR	novel		0.28
SARC	chr4	134199912	Missense_Mutation	novel	H370N	0.11
SARC	chr4	134200544	Missense_Mutation	novel	G159A	0.09
UCEC	chr4	134200617	Missense_Mutation	novel	G135C	0.27
UCEC	chr4	134200403	Missense_Mutation	NA	L206S	0.31
UCEC	chr4	134200086	Missense_Mutation	NA	E312K	0.31	RRM_5
UCEC	chr4	134200414	Silent	novel	D202D	0.42
UCEC	chr4	134200711	Missense_Mutation	NA	K103N	0.4
UCEC	chr4	134200086	Missense_Mutation	NA	E312K	0.46	RRM_5
UCEC	chr4	134201165	5'UTR	novel		0.58
UCEC	chr4	134199814	3'UTR	novel		0.25
UCEC	chr4	134200086	Missense_Mutation	NA	E312K	0.46	RRM_5
UCEC	chr4	134200437	Missense_Mutation	novel	K195Q	0.38
UCEC	chr4	134201112	5'UTR	novel		0.38
UCEC	chr4	134200433	Frame_Shift_Del	novel	*N196Tfs11**	0.26
UCEC	chr4	134200296	Missense_Mutation	NA	A242T	0.37
UCEC	chr4	134200086	Missense_Mutation	NA	E312K	0.38	RRM_5
UCEC	chr4	134200340	Missense_Mutation	novel	G227E	0.48
UCEC	chr4	134200086	Missense_Mutation	NA	E312K	0.22	RRM_5
UCEC	chr4	134200862	Missense_Mutation	novel	Y53F	0.33
UCEC	chr4	134200086	Missense_Mutation	NA	E312K	0.28	RRM_5
UCEC	chr4	134200350	Missense_Mutation	NA	D224Y	0.46
UCEC	chr4	134200288	Missense_Mutation	novel	K244N	0.27
UCEC	chr4	134200293	Missense_Mutation	NA	A243T	0.34
UCEC	chr4	134200275	Nonsense_Mutation	NA	E249*	0.12
UCEC	chr4	134200058	Missense_Mutation	NA	R321I	0.28	RRM_5
UCEC	chr4	134200948	Silent	NA	D24D	0.26
UCEC	chr4	134200124	Missense_Mutation	novel	N299S	0.33	RRM_5
UCEC	chr4	134201027	5'UTR	novel		0.6
UCEC	chr4	134200049	Missense_Mutation	novel	V324A	0.36	RRM_5
UCEC	chr4	134200497	Nonsense_Mutation	novel	R175*	0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	2.13e-13
LUAD	DEL	0.2112	0.050802
MESO	DEL	0.3678	0.075661

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.0097	Kaplan-Meier Survival Analysis
SARC	0.034	Kaplan-Meier Survival Analysis
MESO	0.02	Kaplan-Meier Survival Analysis
UCS	0.0078	Kaplan-Meier Survival Analysis
HNSC	0.025	Kaplan-Meier Survival Analysis
BLCA	0.0036	Kaplan-Meier Survival Analysis
CESC	0.047	Kaplan-Meier Survival Analysis
LAML	0.0059	Kaplan-Meier Survival Analysis
UVM	0.026	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000254535 (Gene tree)
Gene ID: 132430
Gene Symbol: PABPC4L
Alias: N
Full Name: poly(A) binding protein cytoplasmic 4 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,416 bases
Position: chr4:134,196,333-134,201,748
Accession: 31955
RBP type: canonical RBP
Summary: (Poly(A) Binding Protein Cytoplasmic 4 Like) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and RNA transport. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC4.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000463233	RRM_5	PF13893.6	3.6e-14	1	3
ENSP00000463233	RRM_5	PF13893.6	3.6e-14	2	3
ENSP00000463233	RRM_5	PF13893.6	3.6e-14	3	3
ENSP00000463233	RRM_1	PF00076.22	7.1e-85	1	4
ENSP00000463233	RRM_1	PF00076.22	7.1e-85	2	4
ENSP00000463233	RRM_1	PF00076.22	7.1e-85	3	4
ENSP00000463233	RRM_1	PF00076.22	7.1e-85	4	4

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000421491	PABPC4L-201	4944	XM_017007727	ENSP00000463233	370 (aa)	-	P0CB38

Gene Model

Click here to download ENSG00000254535's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000254535	Apolipoproteins B	8.28509725157023E-5	17903299
ENSG00000254535	Platelet Count	8.901e-005	-
ENSG00000254535	Platelet Count	8.901e-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000254535's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000254535	PABPC4L	50	34.722	ENSG00000149187	CELF1	83	34.586
ENSG00000254535	PABPC4L	94	30.178	ENSG00000107105	ELAVL2	99	30.337
ENSG00000254535	PABPC4L	95	33.613	ENSG00000151923	TIAL1	98	33.613
ENSG00000254535	PABPC4L	71	30.726	ENSG00000135486	HNRNPA1	93	32.743
ENSG00000254535	PABPC4L	97	31.361	ENSG00000116001	TIA1	90	33.094
ENSG00000254535	PABPC4L	98	63.265	ENSG00000186288	PABPC1L2A	98	63.265
ENSG00000254535	PABPC4L	98	61.798	ENSG00000174740	PABPC5	99	59.624
ENSG00000254535	PABPC4L	99	72.162	ENSG00000070756	PABPC1	99	73.832
ENSG00000254535	PABPC4L	96	36.111	ENSG00000100461	RBM23	64	36.111
ENSG00000254535	PABPC4L	98	63.265	ENSG00000184388	PABPC1L2B	98	63.265
ENSG00000254535	PABPC4L	97	42.105	ENSG00000143368	SF3B4	78	42.105
ENSG00000254535	PABPC4L	99	75.405	ENSG00000090621	PABPC4	100	76.744
ENSG00000254535	PABPC4L	86	31.707	ENSG00000066044	ELAVL1	82	31.707
ENSG00000254535	PABPC4L	97	31.395	ENSG00000179950	PUF60	62	33.333
ENSG00000254535	PABPC4L	99	63.514	ENSG00000101104	PABPC1L	98	61.728
ENSG00000254535	PABPC4L	62	37.349	ENSG00000099622	CIRBP	98	37.179
ENSG00000254535	PABPC4L	91	30.345	ENSG00000121390	PSPC1	53	30.345
ENSG00000254535	PABPC4L	95	37.500	ENSG00000131051	RBM39	90	37.500
ENSG00000254535	PABPC4L	99	67.838	ENSG00000151846	PABPC3	61	67.838
ENSG00000254535	PABPC4L	82	40.789	ENSG00000102317	RBM3	58	40.789

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000254535	PABPC4L	100	97.027	ENSANAG00000017199	PABPC4L	87	97.027	Aotus_nancymaae
ENSG00000254535	PABPC4L	99	89.702	ENSBTAG00000046902	PABPC4L	99	89.702	Bos_taurus
ENSG00000254535	PABPC4L	100	97.297	ENSCJAG00000045332	PABPC4L	86	97.297	Callithrix_jacchus
ENSG00000254535	PABPC4L	99	73.913	ENSCAFG00020019182	-	54	73.913	Canis_lupus_dingo
ENSG00000254535	PABPC4L	99	89.702	ENSCHIG00000007231	PABPC4L	99	89.702	Capra_hircus
ENSG00000254535	PABPC4L	98	80.896	ENSCAPG00000000555	PABPC4L	100	80.896	Cavia_aperea
ENSG00000254535	PABPC4L	100	78.378	ENSCPOG00000033167	PABPC4L	100	78.378	Cavia_porcellus
ENSG00000254535	PABPC4L	100	97.297	ENSCCAG00000031681	PABPC4L	86	97.297	Cebus_capucinus
ENSG00000254535	PABPC4L	100	83.784	ENSCLAG00000017628	PABPC4L	100	83.784	Chinchilla_lanigera
ENSG00000254535	PABPC4L	100	97.027	ENSCANG00000037677	PABPC4L	100	97.027	Colobus_angolensis_palliatus
ENSG00000254535	PABPC4L	100	82.973	ENSCGRG00001002070	Pabpc4l	100	82.973	Cricetulus_griseus_chok1gshd
ENSG00000254535	PABPC4L	100	82.973	ENSCGRG00000020086	Pabpc4l	100	82.973	Cricetulus_griseus_crigri
ENSG00000254535	PABPC4L	100	92.162	ENSDNOG00000031077	PABPC4L	95	92.162	Dasypus_novemcinctus
ENSG00000254535	PABPC4L	99	89.702	ENSEASG00005007883	PABPC4L	99	89.702	Equus_asinus_asinus
ENSG00000254535	PABPC4L	99	89.973	ENSECAG00000031416	PABPC4L	99	89.973	Equus_caballus
ENSG00000254535	PABPC4L	99	90.244	ENSFCAG00000028270	PABPC4L	99	90.244	Felis_catus
ENSG00000254535	PABPC4L	99	83.740	ENSFDAG00000019606	PABPC4L	99	83.740	Fukomys_damarensis
ENSG00000254535	PABPC4L	100	99.459	ENSGGOG00000024991	PABPC4L	100	99.459	Gorilla_gorilla
ENSG00000254535	PABPC4L	99	84.011	ENSHGLG00000020104	PABPC4L	99	84.011	Heterocephalus_glaber_female
ENSG00000254535	PABPC4L	99	84.011	ENSHGLG00100020648	PABPC4L	99	84.011	Heterocephalus_glaber_male
ENSG00000254535	PABPC4L	100	87.601	ENSSTOG00000019472	PABPC4L	99	87.601	Ictidomys_tridecemlineatus
ENSG00000254535	PABPC4L	99	82.927	ENSJJAG00000004090	Pabpc4l	99	82.927	Jaculus_jaculus
ENSG00000254535	PABPC4L	100	83.243	ENSMAUG00000016313	Pabpc4l	100	83.243	Mesocricetus_auratus
ENSG00000254535	PABPC4L	100	95.135	ENSMICG00000029683	PABPC4L	100	95.135	Microcebus_murinus
ENSG00000254535	PABPC4L	100	84.324	ENSMOCG00000007551	Pabpc4l	100	84.324	Microtus_ochrogaster
ENSG00000254535	PABPC4L	100	81.081	MGP_CAROLIEiJ_G0024968	Pabpc4l	100	81.081	Mus_caroli
ENSG00000254535	PABPC4L	100	81.351	ENSMUSG00000090919	Pabpc4l	100	81.351	Mus_musculus
ENSG00000254535	PABPC4L	100	81.622	MGP_PahariEiJ_G0026409	Pabpc4l	100	81.622	Mus_pahari
ENSG00000254535	PABPC4L	100	80.811	MGP_SPRETEiJ_G0025903	Pabpc4l	100	80.811	Mus_spretus
ENSG00000254535	PABPC4L	99	78.862	ENSMLUG00000008254	PABPC4L	99	78.862	Myotis_lucifugus
ENSG00000254535	PABPC4L	100	87.568	ENSNGAG00000001502	Pabpc4l	100	87.568	Nannospalax_galili
ENSG00000254535	PABPC4L	100	99.459	ENSNLEG00000019300	PABPC4L	100	99.459	Nomascus_leucogenys
ENSG00000254535	PABPC4L	100	87.568	ENSOGAG00000026166	PABPC4L	100	87.568	Otolemur_garnettii
ENSG00000254535	PABPC4L	99	99.690	ENSPPAG00000043745	PABPC4L	93	99.690	Pan_paniscus
ENSG00000254535	PABPC4L	99	89.702	ENSPPRG00000018628	PABPC4L	99	89.702	Panthera_pardus
ENSG00000254535	PABPC4L	99	90.244	ENSPTIG00000010106	PABPC4L	99	90.244	Panthera_tigris_altaica
ENSG00000254535	PABPC4L	99	99.690	ENSPTRG00000045513	-	78	99.690	Pan_troglodytes
ENSG00000254535	PABPC4L	100	83.243	ENSPEMG00000012565	Pabpc4l	100	83.243	Peromyscus_maniculatus_bairdii
ENSG00000254535	PABPC4L	100	95.135	ENSPCOG00000025578	PABPC4L	100	95.135	Propithecus_coquereli
ENSG00000254535	PABPC4L	100	81.892	ENSRNOG00000029749	Pabpc4l	100	81.892	Rattus_norvegicus
ENSG00000254535	PABPC4L	100	95.946	ENSRBIG00000030229	PABPC4L	100	95.946	Rhinopithecus_bieti
ENSG00000254535	PABPC4L	100	95.676	ENSRROG00000020367	PABPC4L	100	95.676	Rhinopithecus_roxellana
ENSG00000254535	PABPC4L	100	95.135	ENSSBOG00000016382	PABPC4L	100	95.135	Saimiri_boliviensis_boliviensis
ENSG00000254535	PABPC4L	99	84.282	ENSSSCG00000009067	PABPC4L	99	84.282	Sus_scrofa
ENSG00000254535	PABPC4L	99	89.431	ENSUAMG00000001289	PABPC4L	99	89.431	Ursus_americanus
ENSG00000254535	PABPC4L	99	89.431	ENSUMAG00000014887	PABPC4L	99	89.431	Ursus_maritimus
ENSG00000254535	PABPC4L	87	76.074	ENSVVUG00000011060	-	74	76.074	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0008143	poly(A) binding	21873635.	IBA	Function
GO:0008266	poly(U) RNA binding	21873635.	IBA	Function
GO:0010494	cytoplasmic stress granule	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.