EuRBPDB

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24100949	Investigating a pathogenic role for TXNDC5 in tumors.	Int J Oncol	2013 Dec	Chang X	doi: 10.3892/ijo.2013.2123
20157732	The influence of TXNDC5 gene on gastric cancer cell.	J Cancer Res Clin Oncol	2010 Oct	Zhang L	doi: 10.1007/s00432-010-0807-x
25500540	The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.	Oncogene	2015 Sep 3	Wang L	doi: 10.1038/onc.2014.401
17895523	Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.	Exp Biol Med (Maywood)	2007 Oct	Wang Y	-
29749460	Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence.	Int J Mol Med	2018 Aug	Tan F	doi: 10.3892/ijmm.2018.3664

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
COAD	chr6	7910561	Silent	novel	T72T	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1889	0.19267
CESC	DEL	0.1186	0.046699
HNSC	DEL	0.1264	0.0011062
LIHC	AMP	0.3784	1.013e-05
LUSC	DEL	0.2016	0.00029978
PAAD	DEL	0.2989	0.00010152
PRAD	DEL	0.065	0.059223
SARC	DEL	0.249	0.014376
SKCM	AMP	0.5313	6.548e-09
UVM	AMP	0.55	2.0409e-06

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0095	Kaplan-Meier Survival Analysis
MESO	0.043	Kaplan-Meier Survival Analysis
HNSC	0.017	Kaplan-Meier Survival Analysis
LUSC	0.0048	Kaplan-Meier Survival Analysis
ESCA	0.0064	Kaplan-Meier Survival Analysis
KIRP	0.0084	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
CESC	0.0041	Kaplan-Meier Survival Analysis
READ	0.04	Kaplan-Meier Survival Analysis
LAML	0.038	Kaplan-Meier Survival Analysis
LGG	0.00082	Kaplan-Meier Survival Analysis
LUAD	0.0068	Kaplan-Meier Survival Analysis

Description

Ensembl ID: ENSG00000239264 (Gene tree)
Gene ID: 81567
Gene Symbol: TXNDC5
Alias: MGC3178|FLJ21353|FLJ90810|EndoPDI|Hcc-2|ERp46|PDIA15
Full Name: thioredoxin domain containing 5
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 29,565 bases
Position: chr6:7,881,250-7,910,814
Accession: 21073
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000469459	TXNDC5-203	715	-	-	- (aa)	-	-
ENST00000379757	TXNDC5-201	2964	-	ENSP00000369081	432 (aa)	-	Q8NBS9
ENST00000475802	TXNDC5-205	582	-	-	- (aa)	-	-
ENST00000460138	TXNDC5-202	2704	-	-	- (aa)	-	-
ENST00000473453	TXNDC5-204	1301	-	ENSP00000420784	324 (aa)	-	Q8NBS9

Gene Model

Pathway

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000239264	rs111331197	6	7883235	T	Blood protein levels	29875488	[1.11-1.61] unit increase	1.36	EFO_0007937
ENSG00000239264	rs182714900	6	7899503	C	Blood protein levels	30072576	[0.49-0.87] unit decrease	0.677	EFO_0007937

Protein-Protein Interaction (PPI)

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000239264	TXNDC5	98	44.954	FBgn0030329	prtp	99	45.245	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21057456.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005783	endoplasmic reticulum	16130169.	TAS	Component
GO:0005788	endoplasmic reticulum lumen	-	IEA	Component
GO:0016853	isomerase activity	-	IEA	Function
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043202	lysosomal lumen	-	TAS	Component
GO:0043277	apoptotic cell clearance	21873635.	IBA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0070062	extracellular exosome	19199708.23533145.	HDA	Component