EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24100949Investigating a pathogenic role for TXNDC5 in tumors.Int J Oncol2013 DecChang Xdoi: 10.3892/ijo.2013.2123
20157732The influence of TXNDC5 gene on gastric cancer cell.J Cancer Res Clin Oncol2010 OctZhang Ldoi: 10.1007/s00432-010-0807-x
25500540The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.Oncogene2015 Sep 3Wang Ldoi: 10.1038/onc.2014.401
17895523Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.Exp Biol Med (Maywood)2007 OctWang Y-
29749460Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence.Int J Mol Med2018 AugTan Fdoi: 10.3892/ijmm.2018.3664

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
COADchr67910561SilentnovelT72T0.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.18890.19267
CESCDEL0.11860.046699
HNSCDEL0.12640.0011062
LIHCAMP0.37841.013e-05
LUSCDEL0.20160.00029978
PAADDEL0.29890.00010152
PRADDEL0.0650.059223
SARCDEL0.2490.014376
SKCMAMP0.53136.548e-09
UVMAMP0.552.0409e-06

Survival Analysis
CancerP-value Q-value
SARC0.0095

Kaplan-Meier Survival Analysis

MESO0.043

Kaplan-Meier Survival Analysis

HNSC0.017

Kaplan-Meier Survival Analysis

LUSC0.0048

Kaplan-Meier Survival Analysis

ESCA0.0064

Kaplan-Meier Survival Analysis

KIRP0.0084

Kaplan-Meier Survival Analysis

BLCA0.016

Kaplan-Meier Survival Analysis

CESC0.0041

Kaplan-Meier Survival Analysis

READ0.04

Kaplan-Meier Survival Analysis

LAML0.038

Kaplan-Meier Survival Analysis

LGG0.00082

Kaplan-Meier Survival Analysis

LUAD0.0068

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000239264 (Gene tree)
Gene ID
81567
Gene Symbol
TXNDC5
Alias
MGC3178|FLJ21353|FLJ90810|EndoPDI|Hcc-2|ERp46|PDIA15
Full Name
thioredoxin domain containing 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
29,565 bases
Position
chr6:7,881,250-7,910,814
Accession
21073
RBP type
non-canonical RBP
Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000469459TXNDC5-203715--- (aa)--
ENST00000379757TXNDC5-2012964-ENSP00000369081432 (aa)-Q8NBS9
ENST00000475802TXNDC5-205582--- (aa)--
ENST00000460138TXNDC5-2022704--- (aa)--
ENST00000473453TXNDC5-2041301-ENSP00000420784324 (aa)-Q8NBS9
Gene Model
Click here to download ENSG00000239264's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000239264rs11133119767883235TBlood protein levels29875488[1.11-1.61] unit increase1.36EFO_0007937
ENSG00000239264rs18271490067899503CBlood protein levels30072576[0.49-0.87] unit decrease0.677EFO_0007937
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000239264's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000239264TXNDC59844.954FBgn0030329prtp9945.245Drosophila_melanogaster
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding21057456.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005783endoplasmic reticulum16130169.TASComponent
GO:0005788endoplasmic reticulum lumen-IEAComponent
GO:0016853isomerase activity-IEAFunction
GO:0035578azurophil granule lumen-TASComponent
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0043202lysosomal lumen-TASComponent
GO:0043277apoptotic cell clearance21873635.IBAProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0045454cell redox homeostasis-IEAProcess
GO:0070062extracellular exosome19199708.23533145.HDAComponent
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