EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28061504DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins.PLoS One2017 Jan 6Nguyen HTdoi: 10.1371/journal.pone.0169587
25776484Dub3 expression correlates with tumor progression and poor prognosis in human epithelial ovarian cancer.Biomed Pharmacother2015 MarZhou Bdoi: 10.1016/j.biopha.2015.01.015
30718431MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.Proc Natl Acad Sci U S A2019 Feb 19Wu Xdoi: 10.1073/pnas.1814742116
28288134DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.Oncogene2017 Aug 17Hernandez-Perez Sdoi: 10.1038/onc.2017.21
30057199DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.Mol Cell2018 Aug 16Jin Xdoi: 10.1016/j.molcel.2018.06.036

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr812138592Missense_MutationnovelP57T0.18
BLCAchr812138482SilentnovelA93A0.47
BLCAchr812138205Missense_MutationnovelH186Y0.18
BLCAchr812138563SilentNAK66K0.09
BLCAchr812138350Silentrs780196046H137H0.37
BLCAchr812137497Missense_Mutationrs375221330E422K0.36HABP4_PAI-RBP1
BLCAchr812138516Missense_MutationnovelL82H0.37
BRCAchr812137651SilentNAL370L0.21
CESCchr812137912Missense_MutationNAF283L0.16
CESCchr812137576Silentrs779644781G395G0.08
CESCchr812137289Missense_Mutationrs756802111S491L0.19
CESCchr812138055Missense_MutationnovelA236T0.24
CESCchr812138237Missense_MutationnovelA175V0.13
CESCchr812137534Missense_Mutationrs774997041K409N0.08HABP4_PAI-RBP1
CESCchr812138340Missense_MutationNAH141Y0.73
CESCchr812138730Missense_Mutationrs550178667E11Q0.51
CESCchr812138480Frame_Shift_InsnovelS94Ffs*620.22
COADchr812137408Silentrs371227729N451N0.17
COADchr812138425Missense_MutationNAE112D0.26
COADchr812138515SilentnovelL82L0.26
COADchr812137355Nonsense_Mutationrs201297814S469*0.36
COADchr812138493Missense_MutationnovelY90H0.13
COADchr812137395Missense_Mutationrs200378249E456K0.14
COADchr812137587Missense_MutationnovelR392G0.13HABP4_PAI-RBP1
COADchr812137715Missense_MutationnovelM349T0.21
COADchr812138455Silentrs780960345P102P0.14
COADchr812137239Missense_MutationNAL508V0.31
COADchr812138748Missense_MutationnovelS5P0.1
COADchr812137395Missense_Mutationrs200378249E456K0.27
COADchr812137665Missense_Mutationrs536115308Q366K0.26
COADchr812137309Silentrs747131547S484S0.14
DLBCchr812137286Missense_Mutationrs201012791T492M0.27
ESCAchr812138650Silentrs368449254L37L0.09
ESCAchr812137263Missense_Mutationrs199889083V500M0.66
ESCAchr812137789SilentnovelV324V0.12
ESCAchr812138573Missense_MutationnovelA63V0.19
ESCAchr812138679Missense_MutationnovelA28T0.06
ESCAchr812137576Silentrs779644781G395G0.08
GBMchr812138531Missense_Mutationrs373630969A77V0.24
GBMchr812137804SilentnovelL319L0.16
GBMchr812137753SilentnovelF336F0.18
GBMchr812138639Missense_MutationnovelS41L0.11
GBMchr812137263Missense_Mutationrs199889083V500M0.82
HNSCchr812137188Missense_Mutationrs779810100A525S0.22
HNSCchr812138544Missense_MutationnovelR73G0.14
HNSCchr812138537Missense_MutationNAP75L0.05
HNSCchr812138664Missense_MutationnovelQ33K0.15
HNSCchr812137185Missense_MutationnovelL526V0.09
HNSCchr812138073Missense_Mutationrs778312568A230S0.2
HNSCchr812138327Missense_MutationnovelP145L0.36
HNSCchr812137639Missense_MutationNAQ374H0.11
LIHCchr812137859Missense_Mutationrs528142888L301P0.09
LIHCchr812137593Missense_MutationNAE390K0.33HABP4_PAI-RBP1
LUADchr812137973Missense_MutationnovelA263D0.37
LUADchr812137319Missense_Mutationrs776605778E481V0.07
LUADchr812138245Missense_MutationnovelM172I0.27
LUADchr812137522SilentnovelP413P0.05
LUADchr812137464Missense_MutationNAT433P0.2HABP4_PAI-RBP1
LUADchr812137971Missense_MutationNAS264T0.09
LUADchr812138468Missense_MutationNAL98Q0.26
LUADchr812137418Missense_MutationnovelP448H0.17HABP4_PAI-RBP1
LUADchr812138758Translation_Start_SitenovelM1?0.08
LUSCchr812137933SilentnovelL276L0.13
LUSCchr812137784Missense_MutationNAA326V0.3
LUSCchr812138279Missense_MutationNAA161D0.26
LUSCchr812138237Missense_MutationnovelA175V0.35
LUSCchr812137522SilentNAP413P0.39
LUSCchr812138257SilentnovelT168T0.13
LUSCchr812138494Nonsense_MutationnovelC89*0.26
LUSCchr812138432Missense_MutationnovelS110Y0.33
LUSCchr812137308Missense_MutationnovelS485T0.11
LUSCchr812138322Missense_MutationnovelQ147K0.21
LUSCchr812137894Missense_MutationnovelN289K0.19
LUSCchr812137440Missense_MutationnovelQ441E0.45HABP4_PAI-RBP1
LUSCchr812138080SilentnovelI227I0.67
LUSCchr812137548Missense_MutationnovelQ405K0.06HABP4_PAI-RBP1
PAADchr812137502Nonsense_MutationnovelL420*0.05HABP4_PAI-RBP1
PAADchr812137244Missense_MutationnovelA506V0.13
PAADchr812137630Missense_MutationnovelE377D0.15
PAADchr812137994Missense_MutationnovelL256P0.09
PCPGchr812138436Silentrs761267593L109L0.3
READchr812138028Nonsense_MutationnovelE245*0.28
READchr812138268Missense_MutationNAL165I0.31
READchr812137289Missense_Mutationrs756802111S491L0.16
SARCchr812137889Missense_MutationnovelL291P0.27
SARCchr812137516SilentnovelL415L0.66
SKCMchr812137232Missense_MutationNAG510E0.32
SKCMchr812138085Missense_MutationnovelD226N0.28
SKCMchr812137396Silentrs374973302V455V0.28
SKCMchr812137486SilentnovelV425V0.18
SKCMchr812137563Missense_MutationNAD400N0.16HABP4_PAI-RBP1
SKCMchr812137593Missense_MutationNAE390K0.33HABP4_PAI-RBP1
SKCMchr812138608SilentnovelL51L0.29
SKCMchr812138127Missense_MutationNAG212R0.32
SKCMchr812137336Missense_MutationNAM475I0.64
SKCMchr812138570Missense_MutationNAP64L0.26
SKCMchr812137335Missense_MutationNAK476E0.13
SKCMchr812137595Missense_Mutationrs763172737R389K0.34HABP4_PAI-RBP1
SKCMchr812137776Missense_MutationNAS329C0.15
SKCMchr812137778Nonsense_Mutationrs752949096W328*0.16
SKCMchr812137169SilentNA*531*0.15
SKCMchr812138542Silentrs760816302R73R0.12
SKCMchr812137868Missense_MutationNAP298L0.06
SKCMchr812137386Silentrs761564697L459L0.14
SKCMchr812137537SilentnovelL408L0.18
SKCMchr812138286Missense_Mutationrs151245022E159K0.2
SKCMchr812138537Missense_MutationNAP75L0.06
SKCMchr812137229Missense_MutationNAR511K0.32
SKCMchr812137450Nonsense_MutationNAW437*0.25HABP4_PAI-RBP1
SKCMchr812137530Missense_MutationnovelD411N0.12HABP4_PAI-RBP1
SKCMchr812138620SilentnovelA47A0.15
SKCMchr812138283Missense_Mutationrs766015132D160N0.11
SKCMchr812138504Missense_Mutationrs770234887G86E0.13
SKCMchr812138467SilentnovelL98L0.88
SKCMchr812137187Missense_MutationnovelA525V0.31
SKCMchr812137362Missense_MutationNAH467Y0.13
SKCMchr812137198Missense_MutationnovelH521Q0.26
SKCMchr812137556Missense_Mutationrs267601744R402P0.06HABP4_PAI-RBP1
SKCMchr812138070Nonsense_MutationnovelQ231*0.34
SKCMchr812137473Nonsense_MutationnovelQ430*0.34HABP4_PAI-RBP1
SKCMchr812138526Missense_MutationNAG79R0.12
SKCMchr812137714Missense_Mutationrs764837008M349I0.68
SKCMchr812138289Nonsense_MutationNAQ158*0.12
SKCMchr812137336Missense_MutationNAM475I0.45
STADchr812137264Silentrs772277926S499S0.03
STADchr812138064Missense_MutationnovelV233I0.36
STADchr812137663Missense_MutationNAQ366H0.13
STADchr812138674Missense_MutationnovelF29L0.4
STADchr812137288Silentrs375258900S491S0.68
STADchr812138413Silentrs3988862T116T0.44
STADchr812138313Missense_MutationnovelA150T0.07
STADchr812137908Missense_MutationNAD285Y0.08
STADchr812138695SilentnovelS22S0.12
STADchr812137583Missense_MutationNAA393V0.17HABP4_PAI-RBP1
STADchr812137283Missense_MutationNAT493N0.05
UCECchr812138470Nonsense_MutationNAC97*0.16
UCECchr812138442Missense_Mutationrs755279564Y107H0.31
UCECchr812138016Missense_MutationnovelE249K0.35
UCECchr812137690SilentNAC357C0.5
UCECchr812138313Missense_MutationnovelA150T0.36
UCECchr812138611SilentnovelD50D0.21
UCECchr812138359Missense_Mutationrs772037870W134C0.25
UCECchr812137867SilentnovelP298P0.21
UCECchr812138424Missense_MutationnovelH113Y0.17
UCECchr812137869Missense_Mutationrs779827922P298T0.13
UCECchr812137861SilentnovelC300C0.25
UCECchr812138130Missense_MutationnovelH211N0.3
UCECchr812137661Missense_MutationnovelA367V0.38
UCECchr812138225Missense_MutationnovelG179D0.19
UCECchr812137653Missense_MutationnovelL370F0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.54664.5185e-08
DLBCDEL0.20830.15679
ESCAAMP0.23372.785e-07
PAADDEL0.22830.050455
READDEL0.55760.20625
UCSDEL0.53570.0031922

Survival Analysis
CancerP-value Q-value
LAML0.024

Kaplan-Meier Survival Analysis

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000223443 (Gene tree)
Gene ID
377630
Gene Symbol
USP17L2
Alias
DUB3
Full Name
ubiquitin specific peptidase 17 like family member 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
1,910 bases
Position
chr8:12,137,168-12,139,077
Accession
34434
RBP type
canonical RBP
Summary
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000333329HABP4_PAI-RBP1PF04774.150.001411

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17109758Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.BMC Genomics2006 Nov 16Shin JM-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000333796USP17L2-2011910-ENSP00000333329530 (aa)-Q6R6M4
Gene Model
Click here to download ENSG00000223443's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000223443's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000223443USP17L210094.340ENSGGOG00000042639-10094.340Gorilla_gorilla
ENSG00000223443USP17L27495.475ENSGGOG00000009925-9495.475Gorilla_gorilla
ENSG00000223443USP17L210087.170ENSGGOG00000043616-10087.170Gorilla_gorilla
ENSG00000223443USP17L27894.712ENSGGOG00000014367-10094.712Gorilla_gorilla
ENSG00000223443USP17L210094.340ENSGGOG00000044031-10094.340Gorilla_gorilla
ENSG00000223443USP17L210088.491ENSMFAG00000043645-9588.491Macaca_fascicularis
ENSG00000223443USP17L28788.961ENSMFAG00000039016-10088.961Macaca_fascicularis
ENSG00000223443USP17L210088.491ENSMFAG00000036389-9588.491Macaca_fascicularis
ENSG00000223443USP17L210088.302ENSMMUG00000049137-10088.302Macaca_mulatta
ENSG00000223443USP17L210088.302ENSMMUG00000040484-10088.302Macaca_mulatta
ENSG00000223443USP17L210088.491ENSMMUG00000047519-10088.491Macaca_mulatta
ENSG00000223443USP17L210086.604ENSMMUG00000039802-10086.604Macaca_mulatta
ENSG00000223443USP17L210089.057ENSMMUG00000041878-10089.057Macaca_mulatta
ENSG00000223443USP17L210081.887ENSMMUG00000044213-10081.887Macaca_mulatta
ENSG00000223443USP17L210088.113ENSMMUG00000041488-10088.113Macaca_mulatta
ENSG00000223443USP17L29987.689ENSMMUG00000045288-9587.689Macaca_mulatta
ENSG00000223443USP17L210083.774ENSMMUG00000042380-9683.774Macaca_mulatta
ENSG00000223443USP17L210088.113ENSMMUG00000049096-9688.113Macaca_mulatta
ENSG00000223443USP17L210088.113ENSMMUG00000042715-10088.113Macaca_mulatta
ENSG00000223443USP17L210088.302ENSMMUG00000029040-9688.302Macaca_mulatta
ENSG00000223443USP17L29979.735ENSMNEG00000033266-9680.114Macaca_nemestrina
ENSG00000223443USP17L210077.444ENSMLEG00000029099-10077.444Mandrillus_leucophaeus
ENSG00000223443USP17L210092.075ENSNLEG00000035477-10092.075Nomascus_leucogenys
ENSG00000223443USP17L210084.717ENSPTRG00000049794-10084.717Pan_troglodytes
ENSG00000223443USP17L28681.271ENSPANG00000034816-9281.271Papio_anubis
ENSG00000223443USP17L210088.491ENSPANG00000029674-10088.491Papio_anubis
ENSG00000223443USP17L210090.476ENSPANG00000035429-10090.476Papio_anubis
ENSG00000223443USP17L210088.491ENSPANG00000031953-10088.491Papio_anubis
ENSG00000223443USP17L210087.547ENSPANG00000035655-10087.547Papio_anubis
ENSG00000223443USP17L28987.764ENSPANG00000032780-10087.764Papio_anubis
ENSG00000223443USP17L210087.547ENSPANG00000032302-10087.547Papio_anubis
ENSG00000223443USP17L210087.170ENSPANG00000029660-10087.170Papio_anubis
ENSG00000223443USP17L210085.849ENSRROG00000032242-9585.849Rhinopithecus_roxellana
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004197cysteine-type endopeptidase activity21873635.IBAFunction
GO:0004843thiol-dependent ubiquitin-specific protease activity21873635.IBAFunction
GO:0004843thiol-dependent ubiquitin-specific protease activity20228808.21239494.IDAFunction
GO:0004843thiol-dependent ubiquitin-specific protease activity19188362.20368735.IMPFunction
GO:0005515protein binding21239494.IPIFunction
GO:0005634nucleus21239494.IDAComponent
GO:0005789endoplasmic reticulum membrane19188362.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006511ubiquitin-dependent protein catabolic process-IEAProcess
GO:0006915apoptotic process-IEAProcess
GO:0007093mitotic cell cycle checkpoint20228808.IMPProcess
GO:0010955negative regulation of protein processing19188362.IMPProcess
GO:0016579protein deubiquitination21873635.IBAProcess
GO:0016579protein deubiquitination20228808.IDAProcess
GO:0016579protein deubiquitination-TASProcess
GO:0030334regulation of cell migration21448158.IMPProcess
GO:0031064negative regulation of histone deacetylation21239494.IMPProcess
GO:0034260negative regulation of GTPase activity19188362.IDAProcess
GO:0036459thiol-dependent ubiquitinyl hydrolase activity20228808.IMPFunction
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TASFunction
GO:0042127regulation of cell proliferation19188362.IMPProcess
GO:0042981regulation of apoptotic process21873635.IBAProcess
GO:0042981regulation of apoptotic process21239494.IMPProcess
GO:0043547positive regulation of GTPase activity21448158.IMPProcess
GO:0050691regulation of defense response to virus by host20368735.IMPProcess
GO:0070536protein K63-linked deubiquitination21239494.IDAProcess
GO:0070536protein K63-linked deubiquitination19188362.20368735.IMPProcess
GO:0071108protein K48-linked deubiquitination19188362.20368735.IMPProcess
GO:0071586CAAX-box protein processing19188362.IMPProcess
GO:0090315negative regulation of protein targeting to membrane19188362.IMPProcess
GO:1900027regulation of ruffle assembly21448158.IMPProcess
GO:1900245positive regulation of MDA-5 signaling pathway20368735.IMPProcess
GO:1900246positive regulation of RIG-I signaling pathway20368735.IMPProcess
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