EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29882471MicroRNA-222 Promotes Invasion and Metastasis of Papillary Thyroid Cancer Through Targeting Protein Phosphatase 2 Regulatory Subunit B Alpha Expression.Thyroid2018 SepHuang Ydoi: 10.1089/thy.2017.0665
26054685miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells.Biomed Pharmacother2015 MayLiang WLdoi: 10.1016/j.biopha.2015.04.015
21872824Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study.Cancer Genet2011 JulCheng Ydoi: 10.1016/j.cancergen.2011.05.002.
25879784Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer.BMC Cancer2015 Apr 15Beca Fdoi: 10.1186/s12885-015-1266-1.
18670647Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.Neoplasia2008 AugLiu W-
26893480PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.Cancer Res2016 Apr 15Hein ALdoi: 10.1158/0008-5472.CAN-15-2119
26297546Upregulation of miR-556-5p promoted prostate cancer cell proliferation by suppressing PPP2R2A expression.Biomed Pharmacother2015 OctZhao Wdoi: 10.1016/j.biopha.2015.07.015
26800397miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells.J Cell Mol Med2016 MarZeng LPdoi: 10.1111/jcmm.12760
29532877Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression.Mol Med Rep2018 MayZhang Jdoi: 10.3892/mmr.2018.8714
29943541[PPP2R2A binds and dephosphorylates GFPT2 in breast cancer cells].Sheng Wu Gong Cheng Xue Bao2018 Jun 25Li Xdoi: 10.13345/j.cjb.170471.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr826360205Missense_MutationnovelD128V0.24
BLCAchr826361082Missense_MutationnovelE190K0.18
BLCAchr8263705173'UTRnovel0.42
BLCAchr8262917595'UTRnovel0.83
BLCAchr826370384SilentNAL439L0.38
BRCAchr826370139Missense_MutationNAV357D0.67
BRCAchr826362683Splice_SitenovelX213_splice0.12
BRCAchr826363773Silentrs367623623I285I0.51
BRCAchr8262917995'UTRnovel0.38
BRCAchr8262918125'UTRrs3762373310.12
CESCchr826360180Missense_MutationNAK120Q0.32
CESCchr826370214Missense_MutationnovelS382L0.2
CESCchr826360198Missense_MutationNAE126K0.37
COADchr826362771Missense_MutationnovelF242S0.08
COADchr8262917365'UTRnovel0.3
COADchr826354481Missense_MutationnovelS65Y0.06
COADchr826370229Missense_MutationnovelK387T0.09
COADchr826360203SilentnovelR127R0.32
COADchr8263704363'UTRnovel0.31
COADchr8262917375'UTRnovel0.45
COADchr8262917365'UTRnovel0.29
COADchr826354599Frame_Shift_InsnovelN106Kfs*110.37
COADchr8262917225'UTRnovel0.45
COADchr8262917375'UTRnovel0.11
COADchr826362830Missense_MutationNAC262G0.25
COADchr8262916985'UTRnovel0.27
COADchr8262917375'UTRnovel0.34
COADchr826363756Frame_Shift_DelNAS282Pfs*100.46
COADchr8262916785'UTRnovel0.42
COADchr826363756Frame_Shift_DelNAS282Pfs*100.37
COADchr826354533SilentnovelP82P0.1
COADchr826361087SilentNAT191T0.09
COADchr826366369Missense_MutationNAF343V0.14
COADchr826370319Missense_MutationnovelK417T0.18
COADchr826338928Nonsense_MutationNAE41*0.28
COADchr8262917375'UTRnovel0.37
COADchr826361142In_Frame_InsnovelR210delinsTW0.04
COADchr826361144SilentnovelR210R0.02
ESCAchr826362809Missense_MutationnovelD255N0.19
ESCAchr8263708263'UTRnovel0.22
GBMchr826354495Nonsense_MutationnovelE70*0.41
GBMchr8263704983'UTRnovel0.67
GBMchr826370321Nonsense_MutationnovelK418*0.15
HNSCchr826362814Missense_MutationNAM256I0.16
HNSCchr826370183Missense_MutationnovelN372D0.2
HNSCchr8262917765'UTRnovel0.14
KIRCchr826360220Missense_MutationNAG133V0.11
KIRPchr826362817SilentnovelR257R0.34
KIRPchr8262916845'UTRnovel0.6
KIRPchr826354475Missense_Mutationrs373174942I63T0.33
KIRPchr826370330Frame_Shift_DelnovelH421Qfs*120.32
LAMLchr826293714Missense_MutationnovelG19V0.09
LGGchr8263704533'UTRrs7578960970.16
LGGchr826370228In_Frame_DelnovelT390_R395del0.42
LGGchr826338895Missense_MutationnovelI30V0.39
LGGchr826360253Missense_MutationnovelR144I0.11
LGGchr826363817Missense_MutationnovelM300T0.32
LIHCchr826366361Missense_MutationnovelD340G0.32
LIHCchr826362835SilentnovelD263D0.33
LIHCchr8262915715'UTRnovel0.59
LUADchr826360282Splice_SitenovelX153_splice0.16
LUADchr826366354Missense_MutationNAE338K0.08
LUADchr826354522Missense_MutationNAS79G0.14
LUADchr826354558Nonsense_MutationnovelE91*0.12
LUADchr826370286Missense_MutationnovelD406V0.07
LUADchr826354534Nonsense_MutationnovelE83*0.31
LUADchr826360985Frame_Shift_InsnovelR158Kfs*80.11
LUADchr826362814Missense_MutationNAM256I0.26
LUSCchr826361110Missense_Mutationrs759228133R199Q0.42
LUSCchr826361016Missense_MutationNAP168S0.15
LUSCchr826370177Missense_MutationNAD370H0.19
LUSCchr826363810Nonsense_MutationNAR298*0.22
OVchr826370337Missense_MutationNAA423V0.53
OVchr826354516Missense_MutationNAF77L0.29
OVchr826362849Splice_SitenovelX268_splice0.13
OVchr826363885Splice_SitenovelX323_splice0.77
PAADchr826293692Missense_MutationnovelW12R0.18
PAADchr826370275Missense_MutationnovelK402N0.06
READchr8262917375'UTRnovel0.31
READchr826370390Missense_MutationnovelI441V0.23
READchr826370215SilentnovelS382S0.33
READchr826338928Nonsense_MutationNAE41*0.22
SARCchr826361039SilentnovelA175A0.4
SARCchr826370309Missense_MutationnovelD414H0.21
SKCMchr826354571Missense_MutationNAK95M0.16
SKCMchr826366369Missense_MutationNAF343V0.06
SKCMchr826338971Missense_MutationNAF55S0.46
SKCMchr826363810Nonsense_MutationNAR298*0.53
SKCMchr826360188Nonsense_MutationNAW122*0.21
SKCMchr826363784Missense_Mutationrs757712148S289L0.3
SKCMchr826360982SilentNAV156V0.45
SKCMchr826363763Missense_MutationNAS282F0.41
SKCMchr826370147Missense_MutationNAG360R0.71
STADchr826360991SilentNAP159P0.24
STADchr826363765Missense_Mutationrs146354435E283K0.16
STADchr826370276Nonsense_MutationNAR403*0.16
STADchr8263705083'UTRrs3774734550.26
STADchr826370177Missense_MutationNAD370H0.08
STADchr8262917375'UTRnovel0.42
STADchr826293674Nonsense_MutationnovelG6*0.14
STADchr826362801Missense_MutationNAR252Q0.29
STADchr826370235Missense_Mutationrs369862992R389H0.26
STADchr826362722Missense_MutationNAT226P0.1
STADchr826370405Missense_MutationNAV446M0.06
STADchr826363845Missense_MutationNAK309N0.07
TGCTchr8262915915'UTRrs5428154990.09
THCAchr8263704723'UTRnovel0.08
THCAchr8263704733'UTRnovel0.08
THYMchr826370192Nonsense_MutationnovelR375*0.2
THYMchr826370235Missense_Mutationrs369862992R389H0.24
UCECchr826293727SilentnovelD23D0.49
UCECchr826363812SilentnovelR298R0.44
UCECchr8263709443'UTRnovel0.45
UCECchr826338898Missense_MutationNAI31L0.49
UCECchr826366408Splice_SitenovelX355_splice0.05
UCECchr826370236SilentNAR389R0.08
UCECchr826370341Nonsense_MutationNAW424*0.48
UCECchr8263710913'UTRnovel0.32
UCECchr826363784Missense_Mutationrs757712148S289L0.06
UCECchr826363818Missense_MutationNAM300I0.24
UCECchr826354592Missense_MutationnovelL102S0.43
UCECchr8262918135'UTRnovel0.29
UCECchr826362800Missense_MutationNAR252W0.32
UCECchr826360208Missense_MutationnovelK129T0.41
UCECchr826360180Missense_MutationNAK120Q0.07
UCECchr826362795Missense_MutationnovelT250N0.27
UCECchr8263706143'UTRnovel0.3
UCECchr826366335SilentNAS331S0.2
UCECchr826366401SilentnovelS353S0.37
UCECchr826338928Nonsense_MutationNAE41*0.48
UCECchr826363785SilentNAS289S0.36
UCECchr8263709833'UTRnovel0.53
UCECchr8263704713'UTRnovel0.24
UCECchr826360211Missense_MutationnovelR130I0.35
UCECchr826361020Missense_MutationNAR169Q0.38
UCECchr8263710913'UTRnovel0.55
UCECchr826370214Missense_MutationnovelS382L0.37
UCECchr8263704963'UTRnovel0.29
UCECchr826338943Nonsense_MutationnovelG46*0.2
UCECchr826370243SilentnovelL392L0.59
UCECchr8263707973'UTRnovel0.42
UCECchr8263704893'UTRnovel0.31
UCECchr826293249Intronnovel0.18
UCECchr826360977Missense_MutationNAP155S0.3
UCECchr826370369Missense_MutationnovelA434S0.06
UCECchr826370250Missense_MutationnovelP394H0.36
UCECchr826361020Missense_MutationNAR169Q0.48
UCECchr826361127Missense_MutationnovelL205M0.22
UCECchr826363810Nonsense_MutationNAR298*0.15
UCECchr826370295Missense_MutationnovelS409I0.19
UCECchr826362801Missense_MutationNAR252Q0.2
UCECchr826362722Missense_MutationnovelT226A0.24
UCSchr8263704763'UTRnovel0.24
UVMchr826354572Missense_MutationnovelK95N0.27

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.55154.5185e-08
DLBCDEL0.22920.15679
ESCADEL0.41850.060925
OVDEL0.69261.6864e-37
PAADDEL0.23370.050455
READDEL0.56970.20625
UCECDEL0.20781.6228e-10
UCSDEL0.51790.0031922

Survival Analysis
CancerP-value Q-value
KIRC0.00031

Kaplan-Meier Survival Analysis

HNSC0.017

Kaplan-Meier Survival Analysis

SKCM0.011

Kaplan-Meier Survival Analysis

KIRP0.014

Kaplan-Meier Survival Analysis

COAD0.028

Kaplan-Meier Survival Analysis

PAAD0.021

Kaplan-Meier Survival Analysis

READ0.028

Kaplan-Meier Survival Analysis

KICH0.0053

Kaplan-Meier Survival Analysis

GBM0.028

Kaplan-Meier Survival Analysis

LIHC0.033

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000221914 (Gene tree)
Gene ID
5520
Gene Symbol
PPP2R2A
Alias
PR52A|PR55A|B55A|PR55alpha|B55alpha
Full Name
protein phosphatase 2 regulatory subunit Balpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
81,190 bases
Position
chr8:26,291,491-26,372,680
Accession
9304
RBP type
non-canonical RBP
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000518254PPP2R2A-206755-ENSP0000042816451 (aa)-E5RJV2
ENST00000518215PPP2R2A-2051163--- (aa)--
ENST00000522150PPP2R2A-216573--- (aa)--
ENST00000519636PPP2R2A-210575--- (aa)--
ENST00000523964PPP2R2A-221567--- (aa)--
ENST00000518397PPP2R2A-207830-ENSP00000429279132 (aa)-E5RIY1
ENST00000523925PPP2R2A-220529-ENSP000004288005 (aa)-UPI0001E8EF84
ENST00000524169PPP2R2A-223784XM_005273560ENSP00000430320197 (aa)XP_005273617E5RFR9
ENST00000521557PPP2R2A-215601-ENSP0000042816514 (aa)-E5RJV1
ENST00000523473PPP2R2A-219654--- (aa)--
ENST00000517754PPP2R2A-2032357--- (aa)--
ENST00000522535PPP2R2A-218653-ENSP000004287053 (aa)-UPI000044C467
ENST00000315985PPP2R2A-2011878XM_011544565ENSP00000325074457 (aa)XP_011542867P63151
ENST00000518890PPP2R2A-2081237--- (aa)--
ENST00000380737PPP2R2A-2023940XM_005273559ENSP00000370113447 (aa)XP_005273616P63151
ENST00000519439PPP2R2A-209658--- (aa)--
ENST00000518208PPP2R2A-2041490--- (aa)--
ENST00000520329PPP2R2A-211836-ENSP0000042854233 (aa)-E5RHQ2
ENST00000522482PPP2R2A-217576--- (aa)--
ENST00000521095PPP2R2A-213579--- (aa)--
ENST00000521484PPP2R2A-214556--- (aa)--
ENST00000524099PPP2R2A-222569--- (aa)--
ENST00000520438PPP2R2A-212409--- (aa)--
ENST00000640787PPP2R2A-224318-ENSP00000491731105 (aa)-A0A1W2PQI2
Gene Model
Click here to download ENSG00000221914's gene model file
Pathways
Pathway IDPathway NameSource
hsa03015mRNA surveillance pathwayKEGG
hsa04071Sphingolipid signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04152AMPK signaling pathwayKEGG
hsa04261Adrenergic signaling in cardiomyocytesKEGG
hsa04390Hippo signaling pathwayKEGG
hsa04530Tight junctionKEGG
hsa04728Dopaminergic synapseKEGG
hsa05142Chagas disease (American trypanosomiasis)KEGG
hsa05160Hepatitis CKEGG
hsa05165Human papillomavirus infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000221914Antihypertensive Agents7.3460000E-005-
ENSG00000221914Body Height4E-823563607
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000221914rs1594829826348561CHeight23563607[NR]1.15EFO_0004339
ENSG00000221914rs190324086826312674?Reaction time29844566[0.0045-0.0113] unit decrease0.0079173EFO_0008393
ENSG00000221914rs191610380826368897?Aspartate aminotransferase levels in excessive alcohol consumption30589442[0.02-0.044] unit increase0.0318EFO_0004736|EFO_0007878
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000221914's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000221914PPP2R2A10082.741FBgn0004889tws9979.138Drosophila_melanogaster
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000086G2/M transition of mitotic cell cycle-TASProcess
GO:0000159protein phosphatase type 2A complex21873635.IBAComponent
GO:0000159protein phosphatase type 2A complex1849734.17245430.IDAComponent
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TASProcess
GO:0000278mitotic cell cycle21873635.IBAProcess
GO:0004722protein serine/threonine phosphatase activity21873635.IBAFunction
GO:0004722protein serine/threonine phosphatase activity1849734.IDAFunction
GO:0005515protein binding9847399.15761952.17245430.17529992.17540176.17632056.18782753.19156129.19293187.19915589.20711181.25816751.26496610.27173435.27588481.28330616.28609714.30611118.IPIFunction
GO:0005654nucleoplasm-TASComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006470protein dephosphorylation1849734.IDAProcess
GO:0007084mitotic nuclear envelope reassembly-TASProcess
GO:0019888protein phosphatase regulator activity1849734.TASFunction
GO:0043278response to morphine-IEAProcess
GO:0043666regulation of phosphoprotein phosphatase activity-IEAProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0048156tau protein binding-IEAFunction
GO:0051721protein phosphatase 2A binding-IEAFunction
GO:0070262peptidyl-serine dephosphorylation21873635.IBAProcess
GO:0098978glutamatergic synapse-IEAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us