EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19161537Expression of CPEB, GAPDH and U6snRNA in cervical and ovarian tissue during cancer development.APMIS2009 JanHansen CNdoi: 10.1111/j.1600-0463.2008.00015.x.
20339377Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.Cell Death Differ2010 OctZhang JHdoi: 10.1038/cdd.2010.32
27142352CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation.Sci Rep2016 May 4Galardi Sdoi: 10.1038/srep25219.
26411364CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis.Oncogene2016 Jun 2Nagaoka Kdoi: 10.1038/onc.2015.350

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1582571457Missense_MutationnovelL89P0.07
BLCAchr1582549487Missense_MutationnovelD458H0.32
BLCAchr1582546467Missense_MutationnovelP517S0.46
BLCAchr1582553531SilentnovelV333V0.53
BLCAchr1582627361Missense_MutationnovelE8Q0.19
BLCAchr1582553950Missense_MutationnovelP301T0.32
BLCAchr1582627216Missense_Mutationrs761900804R56Q0.25
BLCAchr1582553966Missense_MutationnovelW295C0.09
BRCAchr15825444443'UTRnovel0.09
BRCAchr1582555982Missense_MutationnovelS249R0.17
BRCAchr1582549458Splice_SitenovelX467_splice0.18
BRCAchr1582549544Missense_MutationnovelE439Q0.11
BRCAchr1582556121Nonsense_MutationnovelS203*0.16
BRCAchr1582571398Nonsense_MutationnovelR109*0.21
BRCAchr1582549544Missense_MutationnovelE439K0.12
BRCAchr1582553547Missense_MutationnovelV328G0.17
BRCAchr1582557975Missense_Mutationrs374108325L131F0.3
CESCchr15825434463'Flanknovel0.62
CESCchr1582546456Missense_MutationnovelF520L0.35
CESCchr15825436323'Flanknovel0.5
CESCchr1582555971Missense_MutationnovelR253T0.5
CESCchr1582557772SilentnovelL198L0.27
CESCchr1582547185Silentrs374011661S484S0.38
CESCchr1582549582Missense_Mutationrs375054209T426M0.53
CESCchr1582571556Intronnovel0.2
COADchr1582556149Intronnovel0.34
COADchr1582549572Silentrs758545052V429V0.44
COADchr1582571596Intronnovel0.39
COADchr1582556013Missense_MutationnovelA239D0.35
COADchr15825445613'UTRnovel0.34
COADchr1582553896Missense_MutationnovelP319S0.44
COADchr1582547228Missense_MutationnovelR470H0.36
COADchr1582549482SilentnovelT459T0.06
COADchr1582553956Missense_MutationnovelL299I0.51
COADchr1582544641Missense_MutationnovelR546H0.34
COADchr1582553895Missense_MutationnovelP319L0.36
COADchr1582549609Missense_MutationnovelP417L0.12
COADchr1582549572Silentrs758545052V429V0.21
COADchr1582553530Missense_MutationnovelF334V0.29
COADchr1582556189Intronnovel0.43
COADchr15825445823'UTRnovel0.31
COADchr1582547229Missense_MutationnovelR470C0.34
COADchr1582571464Missense_Mutationrs200188266R87C0.32
COADchr1582627283Nonsense_MutationnovelR34*0.29
COADchr1582546449Nonsense_MutationnovelR523*0.03
ESCAchr15825432283'Flanknovel0.24
ESCAchr15825437153'Flanknovel0.21
ESCAchr1582549589Frame_Shift_InsnovelS424Qfs*160.37
GBMchr15825445783'UTRnovel0.88
GBMchr1582555885Missense_MutationnovelH282D0.15
GBMchr1582556000SilentnovelV243V0.13
GBMchr1582553528Frame_Shift_DelnovelF334Lfs*40.06
HNSCchr1582546516Missense_MutationnovelQ500H0.11
HNSCchr15825444993'UTRnovel0.42
HNSCchr1582552596Nonsense_MutationnovelE362*0.25
HNSCchr1582557894Missense_MutationnovelD158H0.09
HNSCchr1582627283Nonsense_MutationnovelR34*0.48
HNSCchr1582557937SilentnovelP143P0.61
HNSCchr1582557938Missense_MutationnovelP143L0.6
KIRCchr1582556161Intronnovel0.28
KIRCchr1582552501Missense_MutationnovelS393R0.25
KIRCchr1582556082Missense_MutationnovelL216P0.14
KIRCchr1582557959Missense_MutationnovelG136V0.28
KIRCchr1582546522Splice_SitenovelX499_splice0.35
LGGchr1582549545SilentnovelA438A0.52
LGGchr1582547164Missense_MutationnovelK491N0.46
LIHCchr1582557822Missense_MutationnovelS182C0.47
LUADchr1582552508Missense_MutationnovelM391K0.1
LUADchr1582553459Splice_Regionnovel0.14
LUADchr1582557924Missense_MutationnovelP148T0.13
LUADchr1582557780Missense_MutationnovelD196H0.08
LUADchr1582555914Missense_MutationnovelP272H0.18
LUADchr1582544674Missense_MutationnovelC535S0.09
LUADchr1582552480Missense_MutationnovelE400D0.15
LUADchr1582557874SilentnovelS164S0.54
LUADchr1582547211Nonsense_MutationnovelQ476*0.34
LUADchr1582557780Missense_MutationnovelD196Y0.19
LUADchr1582571478Missense_MutationnovelA82G0.33
LUADchr1582546513SilentnovelI501I0.43
LUADchr1582552490Missense_MutationnovelR397L0.3
LUADchr1582552581Missense_MutationnovelV367F0.23
LUADchr1582544627SilentnovelL551L0.13
LUSCchr1582556045SilentnovelG228G0.24
LUSCchr1582549604Missense_MutationnovelQ419K0.45
LUSCchr1582571364Missense_Mutationrs370471256A120D0.15
LUSCchr1582555931SilentnovelL266L0.38
LUSCchr1582557837Missense_MutationnovelD177N0.3
LUSCchr1582627305Silentrs745469220T26T0.57
LUSCchr1582546497Missense_MutationnovelD507Y0.17
LUSCchr1582546448Missense_MutationnovelR523L0.12
MESOchr15826479005'UTRnovel0.51
OVchr1582571394Missense_MutationnovelP110H0.31
OVchr1582549658Frame_Shift_DelnovelV401Cfs*30.13
OVchr1582555902Missense_MutationnovelE276V0.3
OVchr1582557874SilentnovelS164S0.33
OVchr1582555898Frame_Shift_DelnovelE278Rfs*110.05
OVchr1582557922Frame_Shift_InsnovelL149Vfs*140.06
PAADchr1582557861Missense_MutationnovelR169C0.04
PAADchr1582547185Missense_MutationnovelS484R0.56
PAADchr1582544642Missense_MutationnovelR546C0.16
PRADchr1582552483Missense_MutationnovelK399N0.21
READchr1582571463Missense_MutationnovelR87H0.37
READchr1582544601Missense_MutationnovelD559E0.06
READchr1582547229Missense_MutationnovelR470S0.37
READchr1582556037Missense_MutationnovelS231Y0.33
READchr1582571413Missense_MutationnovelL104M0.44
READchr1582556180Intronnovel0.31
SARCchr1582628443Intronnovel0.7
SKCMchr1582553494Missense_MutationnovelG346S0.27
SKCMchr1582557831Nonsense_MutationnovelR179*0.41
SKCMchr1582571582Intronnovel0.33
SKCMchr1582549464SilentnovelP465P0.21
SKCMchr1582549465Missense_MutationnovelP465L0.21
SKCMchr1582552499Missense_Mutationrs748240361R394Q0.1
SKCMchr1582555915Missense_MutationnovelP272S0.05
SKCMchr1582555916SilentnovelD271D0.05
SKCMchr1582556090SilentnovelF213F0.17
SKCMchr1582556079Missense_MutationnovelS217L0.16
SKCMchr1582552597Silentrs754255400F361F0.25
SKCMchr1582555913Silentrs754049552P272P0.51
SKCMchr1582557833Missense_MutationnovelS178F0.43
SKCMchr1582553537SilentnovelF331F0.72
SKCMchr1582557879Missense_MutationnovelP163S0.2
SKCMchr1582544607SilentnovelN557N0.27
SKCMchr1582627282Missense_Mutationrs751474815R34Q0.35
SKCMchr1582549620Missense_MutationnovelF413L0.28
SKCMchr1582557947Missense_MutationNAG140E0.34
SKCMchr1582544635Missense_MutationnovelH548R0.23
STADchr1582553481Missense_MutationnovelR350Q0.36
STADchr1582571579Intronnovel0.34
STADchr1582627359Missense_MutationnovelE8D0.38
STADchr1582544627Frame_Shift_DelnovelL551*0.26
STADchr1582547185Silentrs374011661S484S0.27
STADchr1582571478Missense_Mutationrs374422926A82V0.07
STADchr1582627338SilentnovelC15C0.21
STADchr1582549522Missense_MutationnovelN446T0.1
STADchr1582552597Silentrs754255400F361F0.15
STADchr1582549595Missense_MutationnovelD422Y0.17
STADchr1582549487Missense_MutationnovelD458Y0.12
STADchr1582571578Intronnovel0.25
STADchr1582549571Missense_MutationnovelG430S0.1
STADchr1582549635Missense_MutationnovelL408F0.3
STADchr1582549590SilentnovelP423P0.19
UCECchr1582557759Splice_SitenovelX202_splice0.35
UCECchr15825442943'UTRnovel0.29
UCECchr1582571521Missense_MutationnovelS68T0.48
UCECchr15825442953'UTRnovel0.36
UCECchr1582552601Missense_Mutationrs755502093V360G0.1
UCECchr1582557757Splice_Regionnovel0.4
UCECchr1582628493Intronnovel0.53
UCECchr1582546493Missense_MutationnovelS508F0.48
UCECchr1582627255Missense_MutationnovelS43Y0.33
UCECchr1582571602Intronnovel0.28
UCECchr15825439173'Flanknovel0.24
UCECchr1582553890Missense_MutationnovelD321Y0.28
UCECchr1582571657Intronnovel0.44
UCECchr15825445873'UTRnovel0.33
UCECchr1582546449Nonsense_MutationnovelR523*0.14
UCECchr15825437153'Flanknovel0.45
UCECchr15825442903'UTRnovel0.46
UCECchr1582571477Silentrs749124573A82A0.51
UCECchr1582571522Silentrs763080729D67D0.4
UCECchr15825439333'Flanknovel0.62
UCECchr15825442313'Flanknovel0.45
UCECchr1582556011Missense_MutationnovelL240I0.29
UCECchr15825432853'Flanknovel0.31
UCECchr15825442733'UTRnovel0.67
UCECchr15825433373'Flanknovel0.34
UCECchr1582553915Missense_MutationnovelK312N0.33
UCECchr1582553540SilentnovelT330T0.37
UCECchr15825438233'Flanknovel0.39
UCECchr15825438243'Flanknovel0.39
UCECchr1582553507Nonsense_MutationnovelW341*0.36
UCECchr15825434913'Flanknovel0.41
UCECchr15825440023'Flanknovel0.55
UCECchr15825441933'Flanknovel0.33
UCECchr15825443863'UTRnovel0.45
UCECchr15825445813'UTRnovel0.38
UCECchr1582549645Missense_MutationnovelP405H0.5
UCECchr1582555956Missense_MutationnovelS258F0.39
UCECchr15825432323'Flanknovel0.41
UCECchr15825434323'Flanknovel0.28
UCECchr1582556191Intronnovel0.42
UCECchr15825432203'Flanknovel0.06
UCECchr15825437153'Flanknovel0.32
UCECchr1582571430Missense_MutationnovelG98D0.34
UCECchr1582547229Missense_MutationnovelR470C0.44
UCECchr15825434913'Flanknovel0.45
UCECchr1582544628SilentnovelP550P0.12
UCECchr1582628444Intronnovel0.5
UCECchr15825433063'Flanknovel0.05
UCECchr1582555979SilentnovelA250A0.24
UCECchr1582555981Missense_MutationnovelA250T0.24
UCECchr1582556180Intronnovel0.48
UCECchr15825437153'Flanknovel0.33
UCECchr1582556011Missense_MutationnovelL240F0.48
UCECchr15825436693'Flanknovel0.67
UCECchr1582547185Silentrs374011661S484S0.2
UCECchr1582556131Intronnovel0.2
UCECchr1582544595SilentnovelS561S0.38
UCECchr1582556044Missense_Mutationrs202101964V229I0.54
UCECchr15825442953'UTRnovel0.22
UCECchr1582627255Missense_MutationnovelS43Y0.14
UCECchr1582557827Missense_MutationnovelS180Y0.14
UCECchr1582552541Missense_MutationnovelS380N0.27
UCECchr1582553481Missense_MutationnovelR350Q0.21
UCECchr1582556178Intronnovel0.2
UCECchr1582628386Intronnovel0.36
UCECchr15825434113'Flanknovel0.12
UCECchr15825442953'UTRnovel0.47
UCECchr15825443983'UTRnovel0.38
UCECchr1582628290Intronnovel0.65
UCECchr1582546440Splice_SitenovelX525_splice0.12
UCECchr1582553485Missense_MutationnovelP349S0.32
UCECchr15825437153'Flanknovel0.6
UCECchr15825444223'UTRnovel0.32
UCECchr1582549616Missense_MutationnovelR415W0.47
UCECchr15825433933'Flanknovel0.3
UCECchr1582553540SilentnovelT330T0.41
UVMchr1582549515Silentrs368407272L448L0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.21020.0058042
LGGAMP0.01750.19963
PAADAMP0.07070.20695
PAADDEL0.10330.13216
SKCMAMP0.24259.6912e-06

Survival Analysis
CancerP-value Q-value
STAD0.05

Kaplan-Meier Survival Analysis

ACC0.014

Kaplan-Meier Survival Analysis

PRAD0.024

Kaplan-Meier Survival Analysis

BRCA0.035

Kaplan-Meier Survival Analysis

ESCA0.026

Kaplan-Meier Survival Analysis

PAAD0.023

Kaplan-Meier Survival Analysis

BLCA0.0015

Kaplan-Meier Survival Analysis

UCEC0.0032

Kaplan-Meier Survival Analysis

LGG0.0021

Kaplan-Meier Survival Analysis

LUAD0.022

Kaplan-Meier Survival Analysis

UVM0.006

Kaplan-Meier Survival Analysis

OV0.034

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000214575 (Gene tree)
Gene ID
64506
Gene Symbol
CPEB1
Alias
CPEB|CPEB-1|HCPEB-1
Full Name
Cytoplasmic Polyadenylation Element Binding Protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
105,661 bases
Position
chr15:82,543,201-82,648,861
Accession
21744
RBP type
non-canonical RBP
Summary
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9447964Specificity of RNA binding by CPEB: requirement for RNA recognition motifs and a novel zinc finger.Mol Cell Biol1998 FebHake LE-
18631138Translational control in early development: CPEB, P-bodies and germinal granules.Biochem Soc Trans2008 AugStandart Ndoi: 10.1042/BST0360671.
17942399CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.J Biol Chem2007 Dec 28Minshall N-
17024188CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.EMBO J2006 Oct 18Huang YS-
15550246Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.Cell2004 Nov 24Barnard DC-
30237545CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance.Cell Death Dis2018 Sep 20Xu Mdoi: 10.1038/s41419-018-0974-2.
30411210CPEB1 Expression Correlates with Severity of Posttraumatic Ankle Osteoarthritis and Aggravates Catabolic Effect of IL-1β on Chondrocytes.Inflammation2019 AprLi Ldoi: 10.1007/s10753-018-0920-6.
7954828CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation.Cell1994 Nov 18Hake LE-
19887896Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron.Exp Mol Med2010 Jan 31Chae YSdoi: 10.3858/emm.2010.42.1.003.
17506698Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans.Annu Rev Cell Dev Biol2007Kimble J-
25483308Characterization of cytoplasmic polyadenylation element binding 2 protein expression and its RNA binding activity.Hippocampus2015 MayTurimella SLdoi: 10.1002/hipo.22399
27775709RNA-binding protein CPEB1 remodels host and viral RNA landscapes.Nat Struct Mol Biol2016 DecBatra Rdoi: 10.1038/nsmb.3310
10208752Ca2+ is required for phosphorylation of clam p82/CPEB in vitro: implications for dual and independent roles of MAP and Cdc2 kinases.Dev Biol1999 May 1Katsu Y-
12963108Involvement of Xenopus Pumilio in the translational regulation that is specific to cyclin B1 mRNA during oocyte maturation.Mech Dev2003 AugNakahata S-
11780630A conserved role of a DEAD box helicase in mRNA masking.RNA2001 DecMinshall N-
11416189Think globally, translate locally: what mitotic spindles and neuronal synapses have in common.Proc Natl Acad Sci U S A2001 Jun 19Richter JD-
11223249Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein.Gene2001 Jan 24Welk JF-
16314516Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.Mol Cell Biol2005 DecCao Q-
19753328The Relationship between Dendritic Branch Dynamics and CPEB-Labeled RNP Granules Captured in Vivo.Front Neural Circuits2009 Sep 1Bestman JEdoi: 10.3389/neuro.04.010.2009
22917528Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.Behav Brain Res2012 Dec 1Gronli Jdoi: 10.1016/j.bbr.2012.08.008
17938241RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB.Genes Dev2007 Oct 15Kim JH-
17923234Analysis of mRNA translation in cultured hippocampal neurons.Methods Enzymol2007Huang YS-
17015432Control of cellular senescence by CPEB.Genes Dev2006 Oct 1Groisman I-
22164257Cup blocks the precocious activation of the orb autoregulatory loop.PLoS One2011Wong LCdoi: 10.1371/journal.pone.0028261
21460039Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.Genes Dev2011 Apr 1Chen Jdoi: 10.1101/gad.2028911.
20937770CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.Mol Cell Biol2010 DecKan MCdoi: 10.1128/MCB.00716-10
20660482CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3'-UTRs.Nucleic Acids Res2010 NovMorgan Mdoi: 10.1093/nar/gkq635
25452303CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response.Mol Cell Biol2015 FebIvshina Mdoi: 10.1128/MCB.00800-14
23824559A role of CPEB1 in the modulation of proliferation and neuronal maturation of rat primary neural progenitor cells.Neurochem Res2013 SepKim KCdoi: 10.1007/s11064-013-1102-4
23776146Specificity factors in cytoplasmic polyadenylation.Wiley Interdiscip Rev RNA2013 Jul-AugCharlesworth Adoi: 10.1002/wrna.1171.
23434754CPEB1 coordinates alternative 3'-UTR formation with translational regulation.Nature2013 Mar 7Bava FAdoi: 10.1038/nature11901
27037416The Role of Functional Prion-Like Proteins in the Persistence of Memory.Cold Spring Harb Perspect Biol2016 Apr 1Si Kdoi: 10.1101/cshperspect.a021774.
26518186Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones.Dev Neurobiol2016 JulJain Sdoi: 10.1002/dneu.22360
26398195Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.PLoS One2015 Sep 23Giangarra Vdoi: 10.1371/journal.pone.0138794
28383716Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism.Nucleic Acids Res2017 Jun 20Shin Jdoi: 10.1093/nar/gkx239.
28759574Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.PLoS One2017 Jul 31Singh KDdoi: 10.1371/journal.pone.0182270
30145997Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is required for tight-junction assembly for establishment of porcine trophectoderm epithelium.Reprod Fertil Dev2019 JanKwon Jdoi: 10.1071/RD18098.
30662713A continuous model of physiological prion aggregation suggests a role for Orb2 in gating long-term synaptic information.R Soc Open Sci2018 Dec 12Sanguanini Mdoi: 10.1098/rsos.180336
31039976Corrigendum to: Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is required for tight-junction assembly for establishment of porcine trophectoderm epithelium.Reprod Fertil Dev2019 MarKwon Jdoi: 10.1071/RD18098_CO.
9917063The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family.RNA1999 JanWalker J-
11980711N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.EMBO J2002 May 1Huang YS-
11702780Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.Dev Cell2001 AugTay J-
16418484Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation.Genes Dev2006 Jan 15Padmanabhan K-
11526086CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.Development2001 JulHodgman R-
11433366Translational control by CPEB: a means to the end.Nat Rev Mol Cell Biol2001 JulMendez R-
11150246Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein.Dev Biol2001 Jan 15Jin SW-
16043499Activity-dependent polyadenylation in neurons.RNA2005 SepDu L-
15169862Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene.Learn Mem2004 May-JunAlarcon JM-
20040591The nuclear experience of CPEB: implications for RNA processing and translational control.RNA2010 FebLin CLdoi: 10.1261/rna.1779810
19074264The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo.Proc Natl Acad Sci U S A2008 Dec 23Bestman JEdoi: 10.1073/pnas.0806296105
17050619CPEB controls oocyte growth and follicle development in the mouse.Development2006 NovRacki WJ-
22727665Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.Mol Cell2012 Jul 27Udagawa Tdoi: 10.1016/j.molcel.2012.05.016
22456264Transient CPEB dimerization and translational control.RNA2012 MayLin CLdoi: 10.1261/rna.031682.111
22334078CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity.Nat Commun2012 Feb 14Nagaoka Kdoi: 10.1038/ncomms1678.
24990967A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.Genes Dev2014 Jul 1Afroz Tdoi: 10.1101/gad.241133.114.
24634508CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells.J Cell Sci2014 May 15Grudzien-Nogalska Edoi: 10.1242/jcs.144956
27495319Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior.RNA2016 OctMansur Fdoi: 10.1261/rna.056937.116
26926106The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.Nucleic Acids Res2016 Apr 7Yamagishi Rdoi: 10.1093/nar/gkw118
28714992Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs.Nat Struct Mol Biol2017 AugWeill Ldoi: 10.1038/nsmb.3434
29074977The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle.Sci Rep2017 Oct 26Han SJdoi: 10.1038/s41598-017-13688-3.
8665866CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus.EMBO J1996 May 15Stebbins-Boaz B-
14982957The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer.Nucleic Acids Res2004 Feb 24Minshall N-
21865454Cyclin B1 expression regulated by cytoplasmic polyadenylation element binding protein in astrocytes.J Neurosci2011 Aug 24Kim KCdoi: 10.1523/JNEUROSCI.1621-11.2011.
21478871CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation.Nature2011 May 5Burns DMdoi: 10.1038/nature09908
29242136Anxiolytic effect of CPEB1 knockdown on the amygdala of a mouse model of inflammatory pain.Brain Res Bull2018 MarYue Jdoi: 10.1016/j.brainresbull.2017.12.002
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000567678CPEB1-203557-ENSP0000045713717 (aa)-H3BTE4
ENST00000618449CPEB1-2162459-ENSP00000483590491 (aa)-Q9BZB8
ENST00000614977CPEB1-2101559-ENSP00000478841138 (aa)-A0A087WUQ9
ENST00000566716CPEB1-202502--- (aa)--
ENST00000569257CPEB1-205527-ENSP0000045526835 (aa)-H3BPD6
ENST00000620182CPEB1-2182422-ENSP00000484549486 (aa)-Q9BZB8
ENST00000616959CPEB1-2122009-ENSP00000479625564 (aa)-A0A087WVR7
ENST00000617522CPEB1-2142220-ENSP00000481009486 (aa)-Q9BZB8
ENST00000617462CPEB1-2132068-ENSP00000477557486 (aa)-Q9BZB8
ENST00000611163CPEB1-2081919-ENSP00000483857486 (aa)-Q9BZB8
ENST00000563519CPEB1-201536--- (aa)--
ENST00000615198CPEB1-2112112-ENSP00000477715561 (aa)-Q9BZB8
ENST00000568994CPEB1-204554-ENSP00000455044114 (aa)-H3BNX1
ENST00000618698CPEB1-2172885--- (aa)--
ENST00000614918CPEB1-2094882-ENSP00000481010588 (aa)-A0A087WXG7
ENST00000611031CPEB1-2073074-ENSP00000483951561 (aa)-A0A087X171
ENST00000570205CPEB1-206569--- (aa)--
ENST00000617958CPEB1-2152776-ENSP00000478598626 (aa)-A0A024R214
Gene Model
Click here to download ENSG00000214575's gene model file
Pathways
Pathway IDPathway NameSource
hsa04114Oocyte meiosisKEGG
hsa04914Progesterone-mediated oocyte maturationKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214575's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000214575CPEB110069.293ENSDARG00000008454cpeb1b10066.899Danio_rerio
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000900translation repressor activity, mRNA regulatory element binding21873635.IBAFunction
GO:0000900translation repressor activity, mRNA regulatory element binding-ISSFunction
GO:0000932P-body-IEAComponent
GO:0003730mRNA 3'-UTR binding21873635.IBAFunction
GO:0005515protein binding28383716.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus-ISSComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm28383716.IDAComponent
GO:0005737cytoplasm-ISSComponent
GO:0005829cytosol-IDAComponent
GO:0006397mRNA processing-IEAProcess
GO:0006412translation-IEAProcess
GO:0008135translation factor activity, RNA binding21873635.IBAFunction
GO:0014069postsynaptic density-IEAComponent
GO:0030054cell junction-IEAComponent
GO:0030425dendrite-IEAComponent
GO:0032869cellular response to insulin stimulus18752464.IDAProcess
GO:0035925mRNA 3'-UTR AU-rich region binding-ISSFunction
GO:0043005neuron projection21873635.IBAComponent
GO:0043022ribosome binding21873635.IBAFunction
GO:0045202synapse21873635.IBAComponent
GO:0045211postsynaptic membrane-IEAComponent
GO:0046872metal ion binding-IEAFunction
GO:0071230cellular response to amino acid stimulus-ISSProcess
GO:0071456cellular response to hypoxia18752464.IDAProcess
GO:1900365positive regulation of mRNA polyadenylation28383716.IDAProcess
GO:1990124messenger ribonucleoprotein complex21873635.IBAComponent
GO:2000766negative regulation of cytoplasmic translation21873635.IBAProcess
GO:2000766negative regulation of cytoplasmic translation18752464.IMPProcess
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