EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19161537	Expression of CPEB, GAPDH and U6snRNA in cervical and ovarian tissue during cancer development.	APMIS	2009 Jan	Hansen CN	doi: 10.1111/j.1600-0463.2008.00015.x.
20339377	Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.	Cell Death Differ	2010 Oct	Zhang JH	doi: 10.1038/cdd.2010.32
27142352	CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation.	Sci Rep	2016 May 4	Galardi S	doi: 10.1038/srep25219.
26411364	CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis.	Oncogene	2016 Jun 2	Nagaoka K	doi: 10.1038/onc.2015.350

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	82571457	Missense_Mutation	novel	L89P	0.07
BLCA	chr15	82549487	Missense_Mutation	novel	D458H	0.32
BLCA	chr15	82546467	Missense_Mutation	novel	P517S	0.46
BLCA	chr15	82553531	Silent	novel	V333V	0.53
BLCA	chr15	82627361	Missense_Mutation	novel	E8Q	0.19
BLCA	chr15	82553950	Missense_Mutation	novel	P301T	0.32
BLCA	chr15	82627216	Missense_Mutation	rs761900804	R56Q	0.25
BLCA	chr15	82553966	Missense_Mutation	novel	W295C	0.09
BRCA	chr15	82544444	3'UTR	novel		0.09
BRCA	chr15	82555982	Missense_Mutation	novel	S249R	0.17
BRCA	chr15	82549458	Splice_Site	novel	X467_splice	0.18
BRCA	chr15	82549544	Missense_Mutation	novel	E439Q	0.11
BRCA	chr15	82556121	Nonsense_Mutation	novel	S203*	0.16
BRCA	chr15	82571398	Nonsense_Mutation	novel	R109*	0.21
BRCA	chr15	82549544	Missense_Mutation	novel	E439K	0.12
BRCA	chr15	82553547	Missense_Mutation	novel	V328G	0.17
BRCA	chr15	82557975	Missense_Mutation	rs374108325	L131F	0.3
CESC	chr15	82543446	3'Flank	novel		0.62
CESC	chr15	82546456	Missense_Mutation	novel	F520L	0.35
CESC	chr15	82543632	3'Flank	novel		0.5
CESC	chr15	82555971	Missense_Mutation	novel	R253T	0.5
CESC	chr15	82557772	Silent	novel	L198L	0.27
CESC	chr15	82547185	Silent	rs374011661	S484S	0.38
CESC	chr15	82549582	Missense_Mutation	rs375054209	T426M	0.53
CESC	chr15	82571556	Intron	novel		0.2
COAD	chr15	82556149	Intron	novel		0.34
COAD	chr15	82549572	Silent	rs758545052	V429V	0.44
COAD	chr15	82571596	Intron	novel		0.39
COAD	chr15	82556013	Missense_Mutation	novel	A239D	0.35
COAD	chr15	82544561	3'UTR	novel		0.34
COAD	chr15	82553896	Missense_Mutation	novel	P319S	0.44
COAD	chr15	82547228	Missense_Mutation	novel	R470H	0.36
COAD	chr15	82549482	Silent	novel	T459T	0.06
COAD	chr15	82553956	Missense_Mutation	novel	L299I	0.51
COAD	chr15	82544641	Missense_Mutation	novel	R546H	0.34
COAD	chr15	82553895	Missense_Mutation	novel	P319L	0.36
COAD	chr15	82549609	Missense_Mutation	novel	P417L	0.12
COAD	chr15	82549572	Silent	rs758545052	V429V	0.21
COAD	chr15	82553530	Missense_Mutation	novel	F334V	0.29
COAD	chr15	82556189	Intron	novel		0.43
COAD	chr15	82544582	3'UTR	novel		0.31
COAD	chr15	82547229	Missense_Mutation	novel	R470C	0.34
COAD	chr15	82571464	Missense_Mutation	rs200188266	R87C	0.32
COAD	chr15	82627283	Nonsense_Mutation	novel	R34*	0.29
COAD	chr15	82546449	Nonsense_Mutation	novel	R523*	0.03
ESCA	chr15	82543228	3'Flank	novel		0.24
ESCA	chr15	82543715	3'Flank	novel		0.21
ESCA	chr15	82549589	Frame_Shift_Ins	novel	*S424Qfs16**	0.37
GBM	chr15	82544578	3'UTR	novel		0.88
GBM	chr15	82555885	Missense_Mutation	novel	H282D	0.15
GBM	chr15	82556000	Silent	novel	V243V	0.13
GBM	chr15	82553528	Frame_Shift_Del	novel	*F334Lfs4**	0.06
HNSC	chr15	82546516	Missense_Mutation	novel	Q500H	0.11
HNSC	chr15	82544499	3'UTR	novel		0.42
HNSC	chr15	82552596	Nonsense_Mutation	novel	E362*	0.25
HNSC	chr15	82557894	Missense_Mutation	novel	D158H	0.09
HNSC	chr15	82627283	Nonsense_Mutation	novel	R34*	0.48
HNSC	chr15	82557937	Silent	novel	P143P	0.61
HNSC	chr15	82557938	Missense_Mutation	novel	P143L	0.6
KIRC	chr15	82556161	Intron	novel		0.28
KIRC	chr15	82552501	Missense_Mutation	novel	S393R	0.25
KIRC	chr15	82556082	Missense_Mutation	novel	L216P	0.14
KIRC	chr15	82557959	Missense_Mutation	novel	G136V	0.28
KIRC	chr15	82546522	Splice_Site	novel	X499_splice	0.35
LGG	chr15	82549545	Silent	novel	A438A	0.52
LGG	chr15	82547164	Missense_Mutation	novel	K491N	0.46
LIHC	chr15	82557822	Missense_Mutation	novel	S182C	0.47
LUAD	chr15	82552508	Missense_Mutation	novel	M391K	0.1
LUAD	chr15	82553459	Splice_Region	novel		0.14
LUAD	chr15	82557924	Missense_Mutation	novel	P148T	0.13
LUAD	chr15	82557780	Missense_Mutation	novel	D196H	0.08
LUAD	chr15	82555914	Missense_Mutation	novel	P272H	0.18
LUAD	chr15	82544674	Missense_Mutation	novel	C535S	0.09
LUAD	chr15	82552480	Missense_Mutation	novel	E400D	0.15
LUAD	chr15	82557874	Silent	novel	S164S	0.54
LUAD	chr15	82547211	Nonsense_Mutation	novel	Q476*	0.34
LUAD	chr15	82557780	Missense_Mutation	novel	D196Y	0.19
LUAD	chr15	82571478	Missense_Mutation	novel	A82G	0.33
LUAD	chr15	82546513	Silent	novel	I501I	0.43
LUAD	chr15	82552490	Missense_Mutation	novel	R397L	0.3
LUAD	chr15	82552581	Missense_Mutation	novel	V367F	0.23
LUAD	chr15	82544627	Silent	novel	L551L	0.13
LUSC	chr15	82556045	Silent	novel	G228G	0.24
LUSC	chr15	82549604	Missense_Mutation	novel	Q419K	0.45
LUSC	chr15	82571364	Missense_Mutation	rs370471256	A120D	0.15
LUSC	chr15	82555931	Silent	novel	L266L	0.38
LUSC	chr15	82557837	Missense_Mutation	novel	D177N	0.3
LUSC	chr15	82627305	Silent	rs745469220	T26T	0.57
LUSC	chr15	82546497	Missense_Mutation	novel	D507Y	0.17
LUSC	chr15	82546448	Missense_Mutation	novel	R523L	0.12
MESO	chr15	82647900	5'UTR	novel		0.51
OV	chr15	82571394	Missense_Mutation	novel	P110H	0.31
OV	chr15	82549658	Frame_Shift_Del	novel	*V401Cfs3**	0.13
OV	chr15	82555902	Missense_Mutation	novel	E276V	0.3
OV	chr15	82557874	Silent	novel	S164S	0.33
OV	chr15	82555898	Frame_Shift_Del	novel	*E278Rfs11**	0.05
OV	chr15	82557922	Frame_Shift_Ins	novel	*L149Vfs14**	0.06
PAAD	chr15	82557861	Missense_Mutation	novel	R169C	0.04
PAAD	chr15	82547185	Missense_Mutation	novel	S484R	0.56
PAAD	chr15	82544642	Missense_Mutation	novel	R546C	0.16
PRAD	chr15	82552483	Missense_Mutation	novel	K399N	0.21
READ	chr15	82571463	Missense_Mutation	novel	R87H	0.37
READ	chr15	82544601	Missense_Mutation	novel	D559E	0.06
READ	chr15	82547229	Missense_Mutation	novel	R470S	0.37
READ	chr15	82556037	Missense_Mutation	novel	S231Y	0.33
READ	chr15	82571413	Missense_Mutation	novel	L104M	0.44
READ	chr15	82556180	Intron	novel		0.31
SARC	chr15	82628443	Intron	novel		0.7
SKCM	chr15	82553494	Missense_Mutation	novel	G346S	0.27
SKCM	chr15	82557831	Nonsense_Mutation	novel	R179*	0.41
SKCM	chr15	82571582	Intron	novel		0.33
SKCM	chr15	82549464	Silent	novel	P465P	0.21
SKCM	chr15	82549465	Missense_Mutation	novel	P465L	0.21
SKCM	chr15	82552499	Missense_Mutation	rs748240361	R394Q	0.1
SKCM	chr15	82555915	Missense_Mutation	novel	P272S	0.05
SKCM	chr15	82555916	Silent	novel	D271D	0.05
SKCM	chr15	82556090	Silent	novel	F213F	0.17
SKCM	chr15	82556079	Missense_Mutation	novel	S217L	0.16
SKCM	chr15	82552597	Silent	rs754255400	F361F	0.25
SKCM	chr15	82555913	Silent	rs754049552	P272P	0.51
SKCM	chr15	82557833	Missense_Mutation	novel	S178F	0.43
SKCM	chr15	82553537	Silent	novel	F331F	0.72
SKCM	chr15	82557879	Missense_Mutation	novel	P163S	0.2
SKCM	chr15	82544607	Silent	novel	N557N	0.27
SKCM	chr15	82627282	Missense_Mutation	rs751474815	R34Q	0.35
SKCM	chr15	82549620	Missense_Mutation	novel	F413L	0.28
SKCM	chr15	82557947	Missense_Mutation	NA	G140E	0.34
SKCM	chr15	82544635	Missense_Mutation	novel	H548R	0.23
STAD	chr15	82553481	Missense_Mutation	novel	R350Q	0.36
STAD	chr15	82571579	Intron	novel		0.34
STAD	chr15	82627359	Missense_Mutation	novel	E8D	0.38
STAD	chr15	82544627	Frame_Shift_Del	novel	L551*	0.26
STAD	chr15	82547185	Silent	rs374011661	S484S	0.27
STAD	chr15	82571478	Missense_Mutation	rs374422926	A82V	0.07
STAD	chr15	82627338	Silent	novel	C15C	0.21
STAD	chr15	82549522	Missense_Mutation	novel	N446T	0.1
STAD	chr15	82552597	Silent	rs754255400	F361F	0.15
STAD	chr15	82549595	Missense_Mutation	novel	D422Y	0.17
STAD	chr15	82549487	Missense_Mutation	novel	D458Y	0.12
STAD	chr15	82571578	Intron	novel		0.25
STAD	chr15	82549571	Missense_Mutation	novel	G430S	0.1
STAD	chr15	82549635	Missense_Mutation	novel	L408F	0.3
STAD	chr15	82549590	Silent	novel	P423P	0.19
UCEC	chr15	82557759	Splice_Site	novel	X202_splice	0.35
UCEC	chr15	82544294	3'UTR	novel		0.29
UCEC	chr15	82571521	Missense_Mutation	novel	S68T	0.48
UCEC	chr15	82544295	3'UTR	novel		0.36
UCEC	chr15	82552601	Missense_Mutation	rs755502093	V360G	0.1
UCEC	chr15	82557757	Splice_Region	novel		0.4
UCEC	chr15	82628493	Intron	novel		0.53
UCEC	chr15	82546493	Missense_Mutation	novel	S508F	0.48
UCEC	chr15	82627255	Missense_Mutation	novel	S43Y	0.33
UCEC	chr15	82571602	Intron	novel		0.28
UCEC	chr15	82543917	3'Flank	novel		0.24
UCEC	chr15	82553890	Missense_Mutation	novel	D321Y	0.28
UCEC	chr15	82571657	Intron	novel		0.44
UCEC	chr15	82544587	3'UTR	novel		0.33
UCEC	chr15	82546449	Nonsense_Mutation	novel	R523*	0.14
UCEC	chr15	82543715	3'Flank	novel		0.45
UCEC	chr15	82544290	3'UTR	novel		0.46
UCEC	chr15	82571477	Silent	rs749124573	A82A	0.51
UCEC	chr15	82571522	Silent	rs763080729	D67D	0.4
UCEC	chr15	82543933	3'Flank	novel		0.62
UCEC	chr15	82544231	3'Flank	novel		0.45
UCEC	chr15	82556011	Missense_Mutation	novel	L240I	0.29
UCEC	chr15	82543285	3'Flank	novel		0.31
UCEC	chr15	82544273	3'UTR	novel		0.67
UCEC	chr15	82543337	3'Flank	novel		0.34
UCEC	chr15	82553915	Missense_Mutation	novel	K312N	0.33
UCEC	chr15	82553540	Silent	novel	T330T	0.37
UCEC	chr15	82543823	3'Flank	novel		0.39
UCEC	chr15	82543824	3'Flank	novel		0.39
UCEC	chr15	82553507	Nonsense_Mutation	novel	W341*	0.36
UCEC	chr15	82543491	3'Flank	novel		0.41
UCEC	chr15	82544002	3'Flank	novel		0.55
UCEC	chr15	82544193	3'Flank	novel		0.33
UCEC	chr15	82544386	3'UTR	novel		0.45
UCEC	chr15	82544581	3'UTR	novel		0.38
UCEC	chr15	82549645	Missense_Mutation	novel	P405H	0.5
UCEC	chr15	82555956	Missense_Mutation	novel	S258F	0.39
UCEC	chr15	82543232	3'Flank	novel		0.41
UCEC	chr15	82543432	3'Flank	novel		0.28
UCEC	chr15	82556191	Intron	novel		0.42
UCEC	chr15	82543220	3'Flank	novel		0.06
UCEC	chr15	82543715	3'Flank	novel		0.32
UCEC	chr15	82571430	Missense_Mutation	novel	G98D	0.34
UCEC	chr15	82547229	Missense_Mutation	novel	R470C	0.44
UCEC	chr15	82543491	3'Flank	novel		0.45
UCEC	chr15	82544628	Silent	novel	P550P	0.12
UCEC	chr15	82628444	Intron	novel		0.5
UCEC	chr15	82543306	3'Flank	novel		0.05
UCEC	chr15	82555979	Silent	novel	A250A	0.24
UCEC	chr15	82555981	Missense_Mutation	novel	A250T	0.24
UCEC	chr15	82556180	Intron	novel		0.48
UCEC	chr15	82543715	3'Flank	novel		0.33
UCEC	chr15	82556011	Missense_Mutation	novel	L240F	0.48
UCEC	chr15	82543669	3'Flank	novel		0.67
UCEC	chr15	82547185	Silent	rs374011661	S484S	0.2
UCEC	chr15	82556131	Intron	novel		0.2
UCEC	chr15	82544595	Silent	novel	S561S	0.38
UCEC	chr15	82556044	Missense_Mutation	rs202101964	V229I	0.54
UCEC	chr15	82544295	3'UTR	novel		0.22
UCEC	chr15	82627255	Missense_Mutation	novel	S43Y	0.14
UCEC	chr15	82557827	Missense_Mutation	novel	S180Y	0.14
UCEC	chr15	82552541	Missense_Mutation	novel	S380N	0.27
UCEC	chr15	82553481	Missense_Mutation	novel	R350Q	0.21
UCEC	chr15	82556178	Intron	novel		0.2
UCEC	chr15	82628386	Intron	novel		0.36
UCEC	chr15	82543411	3'Flank	novel		0.12
UCEC	chr15	82544295	3'UTR	novel		0.47
UCEC	chr15	82544398	3'UTR	novel		0.38
UCEC	chr15	82628290	Intron	novel		0.65
UCEC	chr15	82546440	Splice_Site	novel	X525_splice	0.12
UCEC	chr15	82553485	Missense_Mutation	novel	P349S	0.32
UCEC	chr15	82543715	3'Flank	novel		0.6
UCEC	chr15	82544422	3'UTR	novel		0.32
UCEC	chr15	82549616	Missense_Mutation	novel	R415W	0.47
UCEC	chr15	82543393	3'Flank	novel		0.3
UCEC	chr15	82553540	Silent	novel	T330T	0.41
UVM	chr15	82549515	Silent	rs368407272	L448L	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2102	0.0058042
LGG	AMP	0.0175	0.19963
PAAD	AMP	0.0707	0.20695
PAAD	DEL	0.1033	0.13216
SKCM	AMP	0.2425	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
STAD	0.05	Kaplan-Meier Survival Analysis
ACC	0.014	Kaplan-Meier Survival Analysis
PRAD	0.024	Kaplan-Meier Survival Analysis
BRCA	0.035	Kaplan-Meier Survival Analysis
ESCA	0.026	Kaplan-Meier Survival Analysis
PAAD	0.023	Kaplan-Meier Survival Analysis
BLCA	0.0015	Kaplan-Meier Survival Analysis
UCEC	0.0032	Kaplan-Meier Survival Analysis
LGG	0.0021	Kaplan-Meier Survival Analysis
LUAD	0.022	Kaplan-Meier Survival Analysis
UVM	0.006	Kaplan-Meier Survival Analysis
OV	0.034	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000214575 (Gene tree)
Gene ID: 64506
Gene Symbol: CPEB1
Alias: CPEB|CPEB-1|HCPEB-1
Full Name: Cytoplasmic Polyadenylation Element Binding Protein 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 105,661 bases
Position: chr15:82,543,201-82,648,861
Accession: 21744
Summary: This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9447964	Specificity of RNA binding by CPEB: requirement for RNA recognition motifs and a novel zinc finger.	Mol Cell Biol	1998 Feb	Hake LE	-
18631138	Translational control in early development: CPEB, P-bodies and germinal granules.	Biochem Soc Trans	2008 Aug	Standart N	doi: 10.1042/BST0360671.
17942399	CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.	J Biol Chem	2007 Dec 28	Minshall N	-
17024188	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	EMBO J	2006 Oct 18	Huang YS	-
15550246	Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.	Cell	2004 Nov 24	Barnard DC	-
30237545	CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance.	Cell Death Dis	2018 Sep 20	Xu M	doi: 10.1038/s41419-018-0974-2.
30411210	CPEB1 Expression Correlates with Severity of Posttraumatic Ankle Osteoarthritis and Aggravates Catabolic Effect of IL-1β on Chondrocytes.	Inflammation	2019 Apr	Li L	doi: 10.1007/s10753-018-0920-6.
7954828	CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation.	Cell	1994 Nov 18	Hake LE	-
19887896	Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron.	Exp Mol Med	2010 Jan 31	Chae YS	doi: 10.3858/emm.2010.42.1.003.
17506698	Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans.	Annu Rev Cell Dev Biol	2007	Kimble J	-
25483308	Characterization of cytoplasmic polyadenylation element binding 2 protein expression and its RNA binding activity.	Hippocampus	2015 May	Turimella SL	doi: 10.1002/hipo.22399
27775709	RNA-binding protein CPEB1 remodels host and viral RNA landscapes.	Nat Struct Mol Biol	2016 Dec	Batra R	doi: 10.1038/nsmb.3310
10208752	Ca2+ is required for phosphorylation of clam p82/CPEB in vitro: implications for dual and independent roles of MAP and Cdc2 kinases.	Dev Biol	1999 May 1	Katsu Y	-
12963108	Involvement of Xenopus Pumilio in the translational regulation that is specific to cyclin B1 mRNA during oocyte maturation.	Mech Dev	2003 Aug	Nakahata S	-
11780630	A conserved role of a DEAD box helicase in mRNA masking.	RNA	2001 Dec	Minshall N	-
11416189	Think globally, translate locally: what mitotic spindles and neuronal synapses have in common.	Proc Natl Acad Sci U S A	2001 Jun 19	Richter JD	-
11223249	Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein.	Gene	2001 Jan 24	Welk JF	-
16314516	Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.	Mol Cell Biol	2005 Dec	Cao Q	-
19753328	The Relationship between Dendritic Branch Dynamics and CPEB-Labeled RNP Granules Captured in Vivo.	Front Neural Circuits	2009 Sep 1	Bestman JE	doi: 10.3389/neuro.04.010.2009
22917528	Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.	Behav Brain Res	2012 Dec 1	Gronli J	doi: 10.1016/j.bbr.2012.08.008
17938241	RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB.	Genes Dev	2007 Oct 15	Kim JH	-
17923234	Analysis of mRNA translation in cultured hippocampal neurons.	Methods Enzymol	2007	Huang YS	-
17015432	Control of cellular senescence by CPEB.	Genes Dev	2006 Oct 1	Groisman I	-
22164257	Cup blocks the precocious activation of the orb autoregulatory loop.	PLoS One	2011	Wong LC	doi: 10.1371/journal.pone.0028261
21460039	Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.	Genes Dev	2011 Apr 1	Chen J	doi: 10.1101/gad.2028911.
20937770	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	Mol Cell Biol	2010 Dec	Kan MC	doi: 10.1128/MCB.00716-10
20660482	CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3'-UTRs.	Nucleic Acids Res	2010 Nov	Morgan M	doi: 10.1093/nar/gkq635
25452303	CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response.	Mol Cell Biol	2015 Feb	Ivshina M	doi: 10.1128/MCB.00800-14
23824559	A role of CPEB1 in the modulation of proliferation and neuronal maturation of rat primary neural progenitor cells.	Neurochem Res	2013 Sep	Kim KC	doi: 10.1007/s11064-013-1102-4
23776146	Specificity factors in cytoplasmic polyadenylation.	Wiley Interdiscip Rev RNA	2013 Jul-Aug	Charlesworth A	doi: 10.1002/wrna.1171.
23434754	CPEB1 coordinates alternative 3'-UTR formation with translational regulation.	Nature	2013 Mar 7	Bava FA	doi: 10.1038/nature11901
27037416	The Role of Functional Prion-Like Proteins in the Persistence of Memory.	Cold Spring Harb Perspect Biol	2016 Apr 1	Si K	doi: 10.1101/cshperspect.a021774.
26518186	Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones.	Dev Neurobiol	2016 Jul	Jain S	doi: 10.1002/dneu.22360
26398195	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	PLoS One	2015 Sep 23	Giangarra V	doi: 10.1371/journal.pone.0138794
28383716	Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism.	Nucleic Acids Res	2017 Jun 20	Shin J	doi: 10.1093/nar/gkx239.
28759574	Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.	PLoS One	2017 Jul 31	Singh KD	doi: 10.1371/journal.pone.0182270
30145997	Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is required for tight-junction assembly for establishment of porcine trophectoderm epithelium.	Reprod Fertil Dev	2019 Jan	Kwon J	doi: 10.1071/RD18098.
30662713	A continuous model of physiological prion aggregation suggests a role for Orb2 in gating long-term synaptic information.	R Soc Open Sci	2018 Dec 12	Sanguanini M	doi: 10.1098/rsos.180336
31039976	Corrigendum to: Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is required for tight-junction assembly for establishment of porcine trophectoderm epithelium.	Reprod Fertil Dev	2019 Mar	Kwon J	doi: 10.1071/RD18098_CO.
9917063	The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family.	RNA	1999 Jan	Walker J	-
11980711	N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.	EMBO J	2002 May 1	Huang YS	-
11702780	Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.	Dev Cell	2001 Aug	Tay J	-
16418484	Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation.	Genes Dev	2006 Jan 15	Padmanabhan K	-
11526086	CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.	Development	2001 Jul	Hodgman R	-
11433366	Translational control by CPEB: a means to the end.	Nat Rev Mol Cell Biol	2001 Jul	Mendez R	-
11150246	Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein.	Dev Biol	2001 Jan 15	Jin SW	-
16043499	Activity-dependent polyadenylation in neurons.	RNA	2005 Sep	Du L	-
15169862	Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene.	Learn Mem	2004 May-Jun	Alarcon JM	-
20040591	The nuclear experience of CPEB: implications for RNA processing and translational control.	RNA	2010 Feb	Lin CL	doi: 10.1261/rna.1779810
19074264	The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo.	Proc Natl Acad Sci U S A	2008 Dec 23	Bestman JE	doi: 10.1073/pnas.0806296105
17050619	CPEB controls oocyte growth and follicle development in the mouse.	Development	2006 Nov	Racki WJ	-
22727665	Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.	Mol Cell	2012 Jul 27	Udagawa T	doi: 10.1016/j.molcel.2012.05.016
22456264	Transient CPEB dimerization and translational control.	RNA	2012 May	Lin CL	doi: 10.1261/rna.031682.111
22334078	CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity.	Nat Commun	2012 Feb 14	Nagaoka K	doi: 10.1038/ncomms1678.
24990967	A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.	Genes Dev	2014 Jul 1	Afroz T	doi: 10.1101/gad.241133.114.
24634508	CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells.	J Cell Sci	2014 May 15	Grudzien-Nogalska E	doi: 10.1242/jcs.144956
27495319	Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior.	RNA	2016 Oct	Mansur F	doi: 10.1261/rna.056937.116
26926106	The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.	Nucleic Acids Res	2016 Apr 7	Yamagishi R	doi: 10.1093/nar/gkw118
28714992	Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs.	Nat Struct Mol Biol	2017 Aug	Weill L	doi: 10.1038/nsmb.3434
29074977	The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle.	Sci Rep	2017 Oct 26	Han SJ	doi: 10.1038/s41598-017-13688-3.
8665866	CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus.	EMBO J	1996 May 15	Stebbins-Boaz B	-
14982957	The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer.	Nucleic Acids Res	2004 Feb 24	Minshall N	-
21865454	Cyclin B1 expression regulated by cytoplasmic polyadenylation element binding protein in astrocytes.	J Neurosci	2011 Aug 24	Kim KC	doi: 10.1523/JNEUROSCI.1621-11.2011.
21478871	CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation.	Nature	2011 May 5	Burns DM	doi: 10.1038/nature09908
29242136	Anxiolytic effect of CPEB1 knockdown on the amygdala of a mouse model of inflammatory pain.	Brain Res Bull	2018 Mar	Yue J	doi: 10.1016/j.brainresbull.2017.12.002

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000567678	CPEB1-203	557	-	ENSP00000457137	17 (aa)	-	H3BTE4
ENST00000618449	CPEB1-216	2459	-	ENSP00000483590	491 (aa)	-	Q9BZB8
ENST00000614977	CPEB1-210	1559	-	ENSP00000478841	138 (aa)	-	A0A087WUQ9
ENST00000566716	CPEB1-202	502	-	-	- (aa)	-	-
ENST00000569257	CPEB1-205	527	-	ENSP00000455268	35 (aa)	-	H3BPD6
ENST00000620182	CPEB1-218	2422	-	ENSP00000484549	486 (aa)	-	Q9BZB8
ENST00000616959	CPEB1-212	2009	-	ENSP00000479625	564 (aa)	-	A0A087WVR7
ENST00000617522	CPEB1-214	2220	-	ENSP00000481009	486 (aa)	-	Q9BZB8
ENST00000617462	CPEB1-213	2068	-	ENSP00000477557	486 (aa)	-	Q9BZB8
ENST00000611163	CPEB1-208	1919	-	ENSP00000483857	486 (aa)	-	Q9BZB8
ENST00000563519	CPEB1-201	536	-	-	- (aa)	-	-
ENST00000615198	CPEB1-211	2112	-	ENSP00000477715	561 (aa)	-	Q9BZB8
ENST00000568994	CPEB1-204	554	-	ENSP00000455044	114 (aa)	-	H3BNX1
ENST00000618698	CPEB1-217	2885	-	-	- (aa)	-	-
ENST00000614918	CPEB1-209	4882	-	ENSP00000481010	588 (aa)	-	A0A087WXG7
ENST00000611031	CPEB1-207	3074	-	ENSP00000483951	561 (aa)	-	A0A087X171
ENST00000570205	CPEB1-206	569	-	-	- (aa)	-	-
ENST00000617958	CPEB1-215	2776	-	ENSP00000478598	626 (aa)	-	A0A024R214

Gene Model

Click here to download ENSG00000214575's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04114	Oocyte meiosis	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214575's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000214575	CPEB1	100	69.293	ENSDARG00000008454	cpeb1b	100	66.899	Danio_rerio

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000900	translation repressor activity, mRNA regulatory element binding	21873635.	IBA	Function
GO:0000900	translation repressor activity, mRNA regulatory element binding	-	ISS	Function
GO:0000932	P-body	-	IEA	Component
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005515	protein binding	28383716.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	28383716.	IDA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0006412	translation	-	IEA	Process
GO:0008135	translation factor activity, RNA binding	21873635.	IBA	Function
GO:0014069	postsynaptic density	-	IEA	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0032869	cellular response to insulin stimulus	18752464.	IDA	Process
GO:0035925	mRNA 3'-UTR AU-rich region binding	-	ISS	Function
GO:0043005	neuron projection	21873635.	IBA	Component
GO:0043022	ribosome binding	21873635.	IBA	Function
GO:0045202	synapse	21873635.	IBA	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0071230	cellular response to amino acid stimulus	-	ISS	Process
GO:0071456	cellular response to hypoxia	18752464.	IDA	Process
GO:1900365	positive regulation of mRNA polyadenylation	28383716.	IDA	Process
GO:1990124	messenger ribonucleoprotein complex	21873635.	IBA	Component
GO:2000766	negative regulation of cytoplasmic translation	21873635.	IBA	Process
GO:2000766	negative regulation of cytoplasmic translation	18752464.	IMP	Process

EuRBPDB

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Eesembl ID

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Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.