EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29151113CPNE1 Is a Useful Prognostic Marker and Is Associated with TNF Receptor-Associated Factor 2 (TRAF2) Expression in Prostate Cancer.Med Sci Monit2017 Nov 19Liang J-
30221693High expression of Copine1 promotes cell growth and metastasis in human lung adenocarcinoma.Int J Oncol2018 DecLiu Sdoi: 10.3892/ijo.2018.4558

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2035632014SilentNAG156G0.14
BLCAchr2035632692Missense_MutationnovelG45V0.27
BLCAchr2035631173Missense_MutationNAV268I0.29
BLCAchr2035626323Missense_MutationNAS511L0.24
BLCAchr2035626270Missense_MutationNAK529E0.31
BLCAchr2035632179Missense_MutationNAR147T0.25
BLCAchr2035631267Splice_SitenovelX267_splice0.35
BLCAchr2035631128Nonsense_MutationnovelQ283*0.13
BLCAchr2035631286Silentrs780991940I261I0.12
BLCAchr2035630707Intronnovel0.1
BLCAchr2035632574Missense_MutationNAK84N0.14
BLCAchr2035632347SilentnovelL116L0.5
BLCAchr2035626723SilentnovelS439S0.08
BLCAchr20356261983'UTRnovel0.48
BLCAchr2035631351Missense_MutationnovelE240K0.23
BRCAchr2035630911Missense_MutationNAD329N0.1
BRCAchr2035631170Missense_MutationnovelE269Q0.06
BRCAchr2035631272Frame_Shift_InsnovelC266Lfs*190.32
BRCAchr2035627366Missense_Mutationrs201918169R384C0.09
BRCAchr2035626792Missense_MutationNAM416I0.49
CESCchr2035630470Missense_MutationnovelL357F0.08
CESCchr2035631295SilentnovelS258S0.24
CESCchr2035631947Missense_MutationNAE179K0.37
CESCchr2035632858SilentNAI22I0.16
CESCchr20356260523'UTRnovel0.53
COADchr2035632565Silentrs375260288E87E0.15
COADchr2035632629Missense_MutationNAY66C0.27
COADchr2035626354Missense_Mutationrs143661266V501M0.46
COADchr20356260913'UTRnovel0.82
COADchr2035630563Intronnovel0.18
COADchr2035631149Missense_MutationnovelD276H0.09
ESCAchr2035631539Missense_MutationnovelL223V0.08
ESCAchr2035630659Intronnovel0.06
ESCAchr2035630697Intronnovel0.28
GBMchr2035631739Missense_MutationnovelF192L0.07
HNSCchr2035631265Splice_Regionnovel0.22
HNSCchr2035626375Missense_Mutationrs757709412R494W0.32
KIRCchr2035631564SilentNAD214D0.39
KIRPchr2035627388Nonsense_MutationNAY376*0.47
LAMLchr2035630684Intronnovel0.06
LIHCchr2035632679SilentNAR49R0.08
LIHCchr20356262093'UTRnovel0.48
LIHCchr2035630955Missense_Mutationrs138805916N314S0.22
LUADchr2035626327Frame_Shift_DelnovelV510Sfs*650.06
LUADchr2035626337SilentnovelP506P0.11
LUADchr2035632892Missense_MutationNAS11C0.08
LUADchr2035630707Intronnovel0.27
LUADchr2035626761Frame_Shift_InsnovelD427*0.08
LUADchr2035631966Missense_MutationnovelW172C0.25
LUADchr2035631967Missense_MutationnovelW172L0.25
LUSCchr2035631156SilentNAS273S0.41
LUSCchr2035627331Missense_MutationnovelI395M0.36
LUSCchr2035632019SilentnovelL155L0.1
MESOchr2035632312Missense_Mutationrs201171766T128M0.23
OVchr2035631982Missense_MutationNAQ167L0.43
OVchr2035632900SilentnovelV8V0.04
READchr2035630688Intronnovel0.17
SARCchr2035626375SilentnovelR494R0.26
SARCchr2035632225Nonsense_MutationNAQ132*0.16
SKCMchr20356262363'UTRnovel0.29
SKCMchr2035627366Missense_Mutationrs201918169R384C0.42
SKCMchr2035632650Missense_MutationNAS59F0.35
SKCMchr2035627363Missense_MutationNAL385F0.27
SKCMchr20356260943'UTRrs7650263650.5
SKCMchr2035632886Missense_MutationnovelS13C0.31
SKCMchr2035631534Silentrs756128504I224I0.32
SKCMchr2035632797Missense_MutationNAE43K0.17
SKCMchr2035631756Missense_MutationnovelP187S0.29
SKCMchr2035631757SilentnovelN186N0.29
SKCMchr2035626254Missense_Mutationrs776135002A534V0.11
SKCMchr2035632527Missense_MutationNAS100F0.35
SKCMchr2035630809Intronnovel0.4
SKCMchr2035630755Missense_MutationNAP346S0.23
SKCMchr2035632323SilentnovelR124R0.23
SKCMchr20356260683'UTRnovel0.53
SKCMchr2035630586Intronnovel0.35
SKCMchr2035626263Missense_MutationNAP531L0.42
SKCMchr2035632320SilentNAG125G0.31
SKCMchr2035632525SilentnovelL101L0.31
STADchr20356260663'UTRnovel0.26
STADchr2035631347Splice_SitenovelX239_splice0.14
STADchr2035630453Missense_MutationNAN363S0.06
STADchr2035626374Missense_Mutationrs754189553R494Q0.21
STADchr2035630937Missense_MutationNAL320P0.23
STADchr2035632858SilentNAI22I0.34
STADchr2035630922Missense_MutationNAS325N0.24
STADchr2035630904Missense_MutationNAD331G0.15
STADchr2035632311Splice_Regionrs376888862T128T0.12
STADchr2035626596Nonsense_MutationnovelQ482*0.11
STADchr20356261343'UTRrs7710021670.21
STADchr2035632199SilentNAV140V0.24
STADchr2035626355Silentrs756243332T500T0.26
STADchr2035626762Silentrs201457688T426T0.18
STADchr2035630920Missense_Mutationrs780606701V326M0.32
THCAchr2035632603Missense_Mutationrs747677512R75C0.09
UCECchr2035626348Missense_Mutationrs774263481A503T0.51
UCECchr2035632320Frame_Shift_DelnovelT126Pfs*90.34
UCECchr2035632631Silentrs146302278E65E0.37
UCECchr2035626295Silentrs573636405P520P0.33
UCECchr2035631539Missense_MutationnovelL223I0.36
UCECchr2035627399Missense_MutationnovelV373M0.73
UCECchr2035626616Missense_MutationNAA475D0.36
UCECchr2035630501Intronnovel0.48
UCECchr2035632225Nonsense_MutationNAQ132*0.42
UCECchr2035631270Missense_Mutationrs371835970R267W0.28
UCECchr20356260743'UTRnovel0.32
UCECchr20356261793'UTRrs7724755300.34
UCECchr2035626759SilentnovelD427D0.19
UCECchr2035630506Intronnovel0.49
UCECchr2035626355Silentrs756243332T500T0.27
UCECchr2035631552Silentrs371307358D218D0.32
UCECchr2035630539Intronnovel0.63
UCECchr2035630603Intronnovel0.46
UCECchr2035626661Missense_MutationnovelQ460R0.27
UCECchr2035626653Missense_Mutationrs778542371A463T0.39
UCECchr2035626336Missense_MutationnovelT507A0.35
UCECchr2035630610Intronnovel0.38
UCECchr2035630985Missense_Mutationrs368463175S304F0.5
UCECchr2035632606Missense_MutationnovelL74I0.48
UCECchr2035632690Missense_MutationnovelR46W0.25
UCECchr2035631550Missense_MutationnovelG219E0.3
UCECchr2035627387Missense_Mutationrs772303395R377C0.43
UCECchr2035630558Intronnovel0.1
UCECchr2035631575Nonsense_Mutationrs770620615Q211*0.17
UCECchr2035653535Intronnovel0.52
UCECchr2035626731Missense_MutationnovelR437C0.08
UCECchr2035627330Missense_MutationnovelN396D0.25
UCECchr20356261263'UTRnovel0.35
UCECchr2035632551Missense_Mutationrs754965752D92G0.17
UCECchr2035627411Missense_MutationnovelI369V0.38
UCECchr2035630804Intronnovel0.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.03330.19593
CHOLDEL0.02780.048655
COADDEL0.00229.4741e-07
LAMLDEL0.01570.14746
MESODEL0.0230.00015289
OVDEL0.04325.3759e-12
PAADDEL0.00540.169
READDEL00.014135
THCADEL00.011063
THYMDEL00.10563
UCSDEL0.01790.1218

Survival Analysis
CancerP-value Q-value
SARC0.036

Kaplan-Meier Survival Analysis

MESO0.0019

Kaplan-Meier Survival Analysis

ACC0.013

Kaplan-Meier Survival Analysis

HNSC0.0019

Kaplan-Meier Survival Analysis

KIRP0.0043

Kaplan-Meier Survival Analysis

KICH0.037

Kaplan-Meier Survival Analysis

UCEC0.01

Kaplan-Meier Survival Analysis

LIHC0.0026

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000214078 (Gene tree)
Gene ID
8904
Gene Symbol
CPNE1
Alias
CPN1
Full Name
copine 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
38,926 bases
Position
chr20:35,626,031-35,664,956
Accession
2314
RBP type
non-canonical RBP
Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18831769Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example.BMC Genomics2008 Oct 3Yang Wdoi: 10.1186/1471-2164-9-456.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000420363CPNE1-211821-ENSP00000401915209 (aa)-Q5JX59
ENST00000430570CPNE1-2121332-ENSP00000390626386 (aa)-Q5JX45
ENST00000439669CPNE1-217784-ENSP00000409305138 (aa)-E7EV27
ENST00000498814CPNE1-228550--- (aa)--
ENST00000498056CPNE1-227362--- (aa)--
ENST00000483495CPNE1-2251853--- (aa)--
ENST00000437100CPNE1-215826-ENSP00000391483152 (aa)-Q5JX55
ENST00000440240CPNE1-219746-ENSP00000397638174 (aa)-Q5JX56
ENST00000435747CPNE1-214400-ENSP0000041280666 (aa)-Q5JX53
ENST00000434795CPNE1-213831-ENSP00000409794201 (aa)-Q5JX58
ENST00000458038CPNE1-220596-ENSP00000390141137 (aa)-Q5JX57
ENST00000415920CPNE1-209731-ENSP00000396069208 (aa)-H0Y524
ENST00000483359CPNE1-2241975--- (aa)--
ENST00000473373CPNE1-222821--- (aa)--
ENST00000401607CPNE1-2051795-ENSP00000386067427 (aa)-E7ENH5
ENST00000486021CPNE1-226506--- (aa)--
ENST00000414711CPNE1-208673-ENSP00000409955136 (aa)-Q5JX54
ENST00000412056CPNE1-206998-ENSP00000416962305 (aa)-Q5JX52
ENST00000437340CPNE1-2161755-ENSP00000415597533 (aa)-F2Z2V0
ENST00000397442CPNE1-2031695-ENSP00000380584481 (aa)-A6PVH9
ENST00000397443CPNE1-2041928-ENSP00000380585537 (aa)-Q99829
ENST00000317677CPNE1-2011961-ENSP00000317257542 (aa)-B0QZ18
ENST00000414664CPNE1-2071070-ENSP00000404355304 (aa)-Q5JX44
ENST00000462352CPNE1-221625--- (aa)--
ENST00000416778CPNE1-210744-ENSP00000389662213 (aa)-Q5JX61
ENST00000439806CPNE1-218748-ENSP00000387434231 (aa)-Q5JX60
ENST00000475146CPNE1-223627--- (aa)--
ENST00000352393CPNE1-2022147-ENSP00000336945537 (aa)-Q99829
Gene Model
Click here to download ENSG00000214078's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000214078Arterial Pressure1.8695450E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000214078rs61424222035628136CLow tan response29739929[0.27-0.59] unit increase0.428EFO_0004279
ENSG00000214078rs124812282035630751CBlood protein levels29875488[0.9-1.06] unit decrease0.98EFO_0007937
ENSG00000214078rs24250682035626801CBlood protein levels29875488[0.41-0.61] unit decrease0.51EFO_0007937
ENSG00000214078rs780840332035632068AIntelligence29942086z-score decrease5.649EFO_0004337
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214078's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001786phosphatidylserine binding9430674.IDAFunction
GO:0004175endopeptidase activity18212740.IDAFunction
GO:0005215transporter activity9430674.TASFunction
GO:0005509calcium ion binding25450385.IMPFunction
GO:0005515protein binding12522145.IPIFunction
GO:0005544calcium-dependent phospholipid binding21873635.IBAFunction
GO:0005634nucleus18212740.21087455.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm21087455.25450385.IDAComponent
GO:0005829cytosol12949241.18212740.IDAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane-TASComponent
GO:0006508proteolysis18212740.IMPProcess
GO:0006629lipid metabolic process9430674.TASProcess
GO:0010629negative regulation of gene expression18212740.IMPProcess
GO:0016020membrane25450385.IDAComponent
GO:0016192vesicle-mediated transport9430674.TASProcess
GO:0031965nuclear membrane-IDAComponent
GO:0035577azurophil granule membrane-TASComponent
GO:0042803protein homodimerization activity18212740.IMPFunction
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling21873635.IBAProcess
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling14674885.IMPProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043392negative regulation of DNA binding18212740.IDAProcess
GO:0045666positive regulation of neuron differentiation23263657.IDAProcess
GO:0045666positive regulation of neuron differentiation25450385.IMPProcess
GO:0046474glycerophospholipid biosynthetic process-TASProcess
GO:0051059NF-kappaB binding18212740.IPIFunction
GO:0051897positive regulation of protein kinase B signaling23263657.IDAProcess
GO:0051897positive regulation of protein kinase B signaling25450385.IMPProcess
GO:0070062extracellular exosome20458337.23533145.HDAComponent
GO:0071277cellular response to calcium ion21873635.IBAProcess
GO:0071277cellular response to calcium ion14674885.IMPProcess
GO:1901223negative regulation of NIK/NF-kappaB signaling18212740.IMPProcess
GO:1903265positive regulation of tumor necrosis factor-mediated signaling pathway21873635.IBAProcess
GO:1903265positive regulation of tumor necrosis factor-mediated signaling pathway14674885.IMPProcess
GO:1990138neuron projection extension23263657.IDAProcess
GO:1990138neuron projection extension25450385.IMPProcess
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