EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29151113	CPNE1 Is a Useful Prognostic Marker and Is Associated with TNF Receptor-Associated Factor 2 (TRAF2) Expression in Prostate Cancer.	Med Sci Monit	2017 Nov 19	Liang J	-
30221693	High expression of Copine1 promotes cell growth and metastasis in human lung adenocarcinoma.	Int J Oncol	2018 Dec	Liu S	doi: 10.3892/ijo.2018.4558

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	35632014	Silent	NA	G156G	0.14
BLCA	chr20	35632692	Missense_Mutation	novel	G45V	0.27
BLCA	chr20	35631173	Missense_Mutation	NA	V268I	0.29
BLCA	chr20	35626323	Missense_Mutation	NA	S511L	0.24
BLCA	chr20	35626270	Missense_Mutation	NA	K529E	0.31
BLCA	chr20	35632179	Missense_Mutation	NA	R147T	0.25
BLCA	chr20	35631267	Splice_Site	novel	X267_splice	0.35
BLCA	chr20	35631128	Nonsense_Mutation	novel	Q283*	0.13
BLCA	chr20	35631286	Silent	rs780991940	I261I	0.12
BLCA	chr20	35630707	Intron	novel		0.1
BLCA	chr20	35632574	Missense_Mutation	NA	K84N	0.14
BLCA	chr20	35632347	Silent	novel	L116L	0.5
BLCA	chr20	35626723	Silent	novel	S439S	0.08
BLCA	chr20	35626198	3'UTR	novel		0.48
BLCA	chr20	35631351	Missense_Mutation	novel	E240K	0.23
BRCA	chr20	35630911	Missense_Mutation	NA	D329N	0.1
BRCA	chr20	35631170	Missense_Mutation	novel	E269Q	0.06
BRCA	chr20	35631272	Frame_Shift_Ins	novel	*C266Lfs19**	0.32
BRCA	chr20	35627366	Missense_Mutation	rs201918169	R384C	0.09
BRCA	chr20	35626792	Missense_Mutation	NA	M416I	0.49
CESC	chr20	35630470	Missense_Mutation	novel	L357F	0.08
CESC	chr20	35631295	Silent	novel	S258S	0.24
CESC	chr20	35631947	Missense_Mutation	NA	E179K	0.37
CESC	chr20	35632858	Silent	NA	I22I	0.16
CESC	chr20	35626052	3'UTR	novel		0.53
COAD	chr20	35632565	Silent	rs375260288	E87E	0.15
COAD	chr20	35632629	Missense_Mutation	NA	Y66C	0.27
COAD	chr20	35626354	Missense_Mutation	rs143661266	V501M	0.46
COAD	chr20	35626091	3'UTR	novel		0.82
COAD	chr20	35630563	Intron	novel		0.18
COAD	chr20	35631149	Missense_Mutation	novel	D276H	0.09
ESCA	chr20	35631539	Missense_Mutation	novel	L223V	0.08
ESCA	chr20	35630659	Intron	novel		0.06
ESCA	chr20	35630697	Intron	novel		0.28
GBM	chr20	35631739	Missense_Mutation	novel	F192L	0.07
HNSC	chr20	35631265	Splice_Region	novel		0.22
HNSC	chr20	35626375	Missense_Mutation	rs757709412	R494W	0.32
KIRC	chr20	35631564	Silent	NA	D214D	0.39
KIRP	chr20	35627388	Nonsense_Mutation	NA	Y376*	0.47
LAML	chr20	35630684	Intron	novel		0.06
LIHC	chr20	35632679	Silent	NA	R49R	0.08
LIHC	chr20	35626209	3'UTR	novel		0.48
LIHC	chr20	35630955	Missense_Mutation	rs138805916	N314S	0.22
LUAD	chr20	35626327	Frame_Shift_Del	novel	*V510Sfs65**	0.06
LUAD	chr20	35626337	Silent	novel	P506P	0.11
LUAD	chr20	35632892	Missense_Mutation	NA	S11C	0.08
LUAD	chr20	35630707	Intron	novel		0.27
LUAD	chr20	35626761	Frame_Shift_Ins	novel	D427*	0.08
LUAD	chr20	35631966	Missense_Mutation	novel	W172C	0.25
LUAD	chr20	35631967	Missense_Mutation	novel	W172L	0.25
LUSC	chr20	35631156	Silent	NA	S273S	0.41
LUSC	chr20	35627331	Missense_Mutation	novel	I395M	0.36
LUSC	chr20	35632019	Silent	novel	L155L	0.1
MESO	chr20	35632312	Missense_Mutation	rs201171766	T128M	0.23
OV	chr20	35631982	Missense_Mutation	NA	Q167L	0.43
OV	chr20	35632900	Silent	novel	V8V	0.04
READ	chr20	35630688	Intron	novel		0.17
SARC	chr20	35626375	Silent	novel	R494R	0.26
SARC	chr20	35632225	Nonsense_Mutation	NA	Q132*	0.16
SKCM	chr20	35626236	3'UTR	novel		0.29
SKCM	chr20	35627366	Missense_Mutation	rs201918169	R384C	0.42
SKCM	chr20	35632650	Missense_Mutation	NA	S59F	0.35
SKCM	chr20	35627363	Missense_Mutation	NA	L385F	0.27
SKCM	chr20	35626094	3'UTR	rs765026365		0.5
SKCM	chr20	35632886	Missense_Mutation	novel	S13C	0.31
SKCM	chr20	35631534	Silent	rs756128504	I224I	0.32
SKCM	chr20	35632797	Missense_Mutation	NA	E43K	0.17
SKCM	chr20	35631756	Missense_Mutation	novel	P187S	0.29
SKCM	chr20	35631757	Silent	novel	N186N	0.29
SKCM	chr20	35626254	Missense_Mutation	rs776135002	A534V	0.11
SKCM	chr20	35632527	Missense_Mutation	NA	S100F	0.35
SKCM	chr20	35630809	Intron	novel		0.4
SKCM	chr20	35630755	Missense_Mutation	NA	P346S	0.23
SKCM	chr20	35632323	Silent	novel	R124R	0.23
SKCM	chr20	35626068	3'UTR	novel		0.53
SKCM	chr20	35630586	Intron	novel		0.35
SKCM	chr20	35626263	Missense_Mutation	NA	P531L	0.42
SKCM	chr20	35632320	Silent	NA	G125G	0.31
SKCM	chr20	35632525	Silent	novel	L101L	0.31
STAD	chr20	35626066	3'UTR	novel		0.26
STAD	chr20	35631347	Splice_Site	novel	X239_splice	0.14
STAD	chr20	35630453	Missense_Mutation	NA	N363S	0.06
STAD	chr20	35626374	Missense_Mutation	rs754189553	R494Q	0.21
STAD	chr20	35630937	Missense_Mutation	NA	L320P	0.23
STAD	chr20	35632858	Silent	NA	I22I	0.34
STAD	chr20	35630922	Missense_Mutation	NA	S325N	0.24
STAD	chr20	35630904	Missense_Mutation	NA	D331G	0.15
STAD	chr20	35632311	Splice_Region	rs376888862	T128T	0.12
STAD	chr20	35626596	Nonsense_Mutation	novel	Q482*	0.11
STAD	chr20	35626134	3'UTR	rs771002167		0.21
STAD	chr20	35632199	Silent	NA	V140V	0.24
STAD	chr20	35626355	Silent	rs756243332	T500T	0.26
STAD	chr20	35626762	Silent	rs201457688	T426T	0.18
STAD	chr20	35630920	Missense_Mutation	rs780606701	V326M	0.32
THCA	chr20	35632603	Missense_Mutation	rs747677512	R75C	0.09
UCEC	chr20	35626348	Missense_Mutation	rs774263481	A503T	0.51
UCEC	chr20	35632320	Frame_Shift_Del	novel	*T126Pfs9**	0.34
UCEC	chr20	35632631	Silent	rs146302278	E65E	0.37
UCEC	chr20	35626295	Silent	rs573636405	P520P	0.33
UCEC	chr20	35631539	Missense_Mutation	novel	L223I	0.36
UCEC	chr20	35627399	Missense_Mutation	novel	V373M	0.73
UCEC	chr20	35626616	Missense_Mutation	NA	A475D	0.36
UCEC	chr20	35630501	Intron	novel		0.48
UCEC	chr20	35632225	Nonsense_Mutation	NA	Q132*	0.42
UCEC	chr20	35631270	Missense_Mutation	rs371835970	R267W	0.28
UCEC	chr20	35626074	3'UTR	novel		0.32
UCEC	chr20	35626179	3'UTR	rs772475530		0.34
UCEC	chr20	35626759	Silent	novel	D427D	0.19
UCEC	chr20	35630506	Intron	novel		0.49
UCEC	chr20	35626355	Silent	rs756243332	T500T	0.27
UCEC	chr20	35631552	Silent	rs371307358	D218D	0.32
UCEC	chr20	35630539	Intron	novel		0.63
UCEC	chr20	35630603	Intron	novel		0.46
UCEC	chr20	35626661	Missense_Mutation	novel	Q460R	0.27
UCEC	chr20	35626653	Missense_Mutation	rs778542371	A463T	0.39
UCEC	chr20	35626336	Missense_Mutation	novel	T507A	0.35
UCEC	chr20	35630610	Intron	novel		0.38
UCEC	chr20	35630985	Missense_Mutation	rs368463175	S304F	0.5
UCEC	chr20	35632606	Missense_Mutation	novel	L74I	0.48
UCEC	chr20	35632690	Missense_Mutation	novel	R46W	0.25
UCEC	chr20	35631550	Missense_Mutation	novel	G219E	0.3
UCEC	chr20	35627387	Missense_Mutation	rs772303395	R377C	0.43
UCEC	chr20	35630558	Intron	novel		0.1
UCEC	chr20	35631575	Nonsense_Mutation	rs770620615	Q211*	0.17
UCEC	chr20	35653535	Intron	novel		0.52
UCEC	chr20	35626731	Missense_Mutation	novel	R437C	0.08
UCEC	chr20	35627330	Missense_Mutation	novel	N396D	0.25
UCEC	chr20	35626126	3'UTR	novel		0.35
UCEC	chr20	35632551	Missense_Mutation	rs754965752	D92G	0.17
UCEC	chr20	35627411	Missense_Mutation	novel	I369V	0.38
UCEC	chr20	35630804	Intron	novel		0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0333	0.19593
CHOL	DEL	0.0278	0.048655
COAD	DEL	0.0022	9.4741e-07
LAML	DEL	0.0157	0.14746
MESO	DEL	0.023	0.00015289
OV	DEL	0.0432	5.3759e-12
PAAD	DEL	0.0054	0.169
READ	DEL	0	0.014135
THCA	DEL	0	0.011063
THYM	DEL	0	0.10563
UCS	DEL	0.0179	0.1218

Survival Analysis

Cancer	P-value	Q-value
SARC	0.036	Kaplan-Meier Survival Analysis
MESO	0.0019	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
HNSC	0.0019	Kaplan-Meier Survival Analysis
KIRP	0.0043	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
UCEC	0.01	Kaplan-Meier Survival Analysis
LIHC	0.0026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000214078 (Gene tree)
Gene ID: 8904
Gene Symbol: CPNE1
Alias: CPN1
Full Name: copine 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 38,926 bases
Position: chr20:35,626,031-35,664,956
Accession: 2314
RBP type: non-canonical RBP
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18831769	Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example.	BMC Genomics	2008 Oct 3	Yang W	doi: 10.1186/1471-2164-9-456.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000420363	CPNE1-211	821	-	ENSP00000401915	209 (aa)	-	Q5JX59
ENST00000430570	CPNE1-212	1332	-	ENSP00000390626	386 (aa)	-	Q5JX45
ENST00000439669	CPNE1-217	784	-	ENSP00000409305	138 (aa)	-	E7EV27
ENST00000498814	CPNE1-228	550	-	-	- (aa)	-	-
ENST00000498056	CPNE1-227	362	-	-	- (aa)	-	-
ENST00000483495	CPNE1-225	1853	-	-	- (aa)	-	-
ENST00000437100	CPNE1-215	826	-	ENSP00000391483	152 (aa)	-	Q5JX55
ENST00000440240	CPNE1-219	746	-	ENSP00000397638	174 (aa)	-	Q5JX56
ENST00000435747	CPNE1-214	400	-	ENSP00000412806	66 (aa)	-	Q5JX53
ENST00000434795	CPNE1-213	831	-	ENSP00000409794	201 (aa)	-	Q5JX58
ENST00000458038	CPNE1-220	596	-	ENSP00000390141	137 (aa)	-	Q5JX57
ENST00000415920	CPNE1-209	731	-	ENSP00000396069	208 (aa)	-	H0Y524
ENST00000483359	CPNE1-224	1975	-	-	- (aa)	-	-
ENST00000473373	CPNE1-222	821	-	-	- (aa)	-	-
ENST00000401607	CPNE1-205	1795	-	ENSP00000386067	427 (aa)	-	E7ENH5
ENST00000486021	CPNE1-226	506	-	-	- (aa)	-	-
ENST00000414711	CPNE1-208	673	-	ENSP00000409955	136 (aa)	-	Q5JX54
ENST00000412056	CPNE1-206	998	-	ENSP00000416962	305 (aa)	-	Q5JX52
ENST00000437340	CPNE1-216	1755	-	ENSP00000415597	533 (aa)	-	F2Z2V0
ENST00000397442	CPNE1-203	1695	-	ENSP00000380584	481 (aa)	-	A6PVH9
ENST00000397443	CPNE1-204	1928	-	ENSP00000380585	537 (aa)	-	Q99829
ENST00000317677	CPNE1-201	1961	-	ENSP00000317257	542 (aa)	-	B0QZ18
ENST00000414664	CPNE1-207	1070	-	ENSP00000404355	304 (aa)	-	Q5JX44
ENST00000462352	CPNE1-221	625	-	-	- (aa)	-	-
ENST00000416778	CPNE1-210	744	-	ENSP00000389662	213 (aa)	-	Q5JX61
ENST00000439806	CPNE1-218	748	-	ENSP00000387434	231 (aa)	-	Q5JX60
ENST00000475146	CPNE1-223	627	-	-	- (aa)	-	-
ENST00000352393	CPNE1-202	2147	-	ENSP00000336945	537 (aa)	-	Q99829

Gene Model

Click here to download ENSG00000214078's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000214078	Arterial Pressure	1.8695450E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000214078	rs6142422	20	35628136	C	Low tan response	29739929	[0.27-0.59] unit increase	0.428	EFO_0004279
ENSG00000214078	rs12481228	20	35630751	C	Blood protein levels	29875488	[0.9-1.06] unit decrease	0.98	EFO_0007937
ENSG00000214078	rs2425068	20	35626801	C	Blood protein levels	29875488	[0.41-0.61] unit decrease	0.51	EFO_0007937
ENSG00000214078	rs78084033	20	35632068	A	Intelligence	29942086	z-score decrease	5.649	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214078's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001786	phosphatidylserine binding	9430674.	IDA	Function
GO:0004175	endopeptidase activity	18212740.	IDA	Function
GO:0005215	transporter activity	9430674.	TAS	Function
GO:0005509	calcium ion binding	25450385.	IMP	Function
GO:0005515	protein binding	12522145.	IPI	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005634	nucleus	18212740.21087455.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21087455.25450385.	IDA	Component
GO:0005829	cytosol	12949241.18212740.	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006508	proteolysis	18212740.	IMP	Process
GO:0006629	lipid metabolic process	9430674.	TAS	Process
GO:0010629	negative regulation of gene expression	18212740.	IMP	Process
GO:0016020	membrane	25450385.	IDA	Component
GO:0016192	vesicle-mediated transport	9430674.	TAS	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0042803	protein homodimerization activity	18212740.	IMP	Function
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	21873635.	IBA	Process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	14674885.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043392	negative regulation of DNA binding	18212740.	IDA	Process
GO:0045666	positive regulation of neuron differentiation	23263657.	IDA	Process
GO:0045666	positive regulation of neuron differentiation	25450385.	IMP	Process
GO:0046474	glycerophospholipid biosynthetic process	-	TAS	Process
GO:0051059	NF-kappaB binding	18212740.	IPI	Function
GO:0051897	positive regulation of protein kinase B signaling	23263657.	IDA	Process
GO:0051897	positive regulation of protein kinase B signaling	25450385.	IMP	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0071277	cellular response to calcium ion	21873635.	IBA	Process
GO:0071277	cellular response to calcium ion	14674885.	IMP	Process
GO:1901223	negative regulation of NIK/NF-kappaB signaling	18212740.	IMP	Process
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	21873635.	IBA	Process
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	14674885.	IMP	Process
GO:1990138	neuron projection extension	23263657.	IDA	Process
GO:1990138	neuron projection extension	25450385.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.