EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19049977Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.J Biol Chem2009 Feb 6Arzoine Ldoi: 10.1074/jbc.M803614200
27080741Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in cancer cell differentiation.Biochim Biophys Acta2016 AugArif Tdoi: 10.1016/j.bbabio.2016.04.005
25341036Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation.Cell Death Dis2014 Oct 23Huang Hdoi: 10.1038/cddis.2014.419.
26716410Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells.Oncotarget2016 Jan 26Wu CHdoi: 10.18632/oncotarget.6704.
26646027Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer.Cell Physiol Biochem2015Gao Wdoi: 10.1159/000438588
22589539Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.J Biol Chem2012 Jun 29Arbel Ndoi: 10.1074/jbc.M112.345918
19094960Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase.Biochim Biophys Acta2009 MayShoshan-Barmatz Vdoi: 10.1016/j.bbabio.2008.11.009
27419626Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma.Oncotarget2016 Aug 9Zhang Cdoi: 10.18632/oncotarget.10562.
27304056Decreased expression of microRNA-320a promotes proliferation and invasion of non-small cell lung cancer cells by increasing VDAC1 expression.Oncotarget2016 Aug 2Zhang Gdoi: 10.18632/oncotarget.9943.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5133973800Missense_MutationnovelL251V0.27
BLCAchr5133991062Silentrs201680896T70T0.12
BLCAchr5133991135Missense_Mutationrs769081892S46L0.24
BLCAchr5133990867Missense_MutationnovelS104L0.16
BRCAchr5133991073Missense_MutationnovelY67H0.12
BRCAchr5133992981Missense_MutationnovelG11D0.06
BRCAchr5133975922Silentrs542220207T217T0.26
BRCAchr5133980836SilentnovelG148G0.08
CESCchr5133991124Missense_MutationNAE50Q0.48
CESCchr51339723603'UTRnovel0.5
COADchr5133980797Missense_MutationnovelK161N0.29
COADchr5133972821Missense_Mutationrs774989304V268I0.16
COADchr5133991053Missense_MutationNAE73D0.15
COADchr5133975974In_Frame_InsnovelK200delinsIPTE0.05
COADchr5133975920Missense_Mutationrs768574647R218H0.15
COADchr5133980793Nonsense_MutationNAR163*0.4
ESCAchr5133991066Missense_MutationnovelL69P0.4
GBMchr5133980735Missense_MutationnovelT182S0.21
GBMchr5133980826Missense_MutationnovelG152C0.06
GBMchr5133991006Missense_MutationnovelD89G0.08
HNSCchr5133991116SilentnovelT52T0.16
LAMLchr5133991119SilentnovelT51T0.04
LAMLchr5133972800Missense_MutationnovelL275F0.14
LIHCchr5133991004Nonsense_MutationnovelQ90*0.46
LIHCchr5133980946Missense_MutationnovelA112P0.16
LIHCchr5133975884Missense_MutationnovelD230G0.12
LUADchr5133972791Missense_Mutationrs756691461G278R0.48
LUSCchr5133980841Missense_MutationNAE147K0.31
OVchr5133980743Missense_MutationnovelQ179H0.07
OVchr5133975923Missense_MutationnovelT217M0.53
OVchr5133991020SilentnovelE84E0.15
PAADchr5133991058Missense_Mutationrs774695024T72A0.19
PRADchr5133991063Missense_Mutationrs767734111T70M0.13
READchr51339727683'UTRnovel0.08
SARCchr5133972778Missense_MutationnovelQ282P0.12
SARCchr51339727373'UTRnovel0.39
SKCMchr5133980745Nonsense_MutationNAQ179*0.25
SKCMchr5133980874Missense_MutationnovelP136S0.23
STADchr5133992348SilentNAG25G0.29
STADchr5133975922Silentrs542220207T217T0.43
STADchr5133993000Missense_MutationNAP5S0.32
STADchr5133973842Missense_MutationNAV237M0.3
STADchr5133975945Missense_MutationNAW210R0.04
THCAchr5133975921Missense_Mutationrs375779223R218C0.21
UCECchr5133980886Missense_Mutationrs377065269D132N0.63
UCECchr5133991040Missense_MutationNAD78N0.32
UCECchr51339723343'UTRnovel0.3
UCECchr51339727613'UTRnovel0.33
UCECchr51339727603'UTRnovel0.47
UCECchr5133980919Nonsense_MutationnovelE121*0.26
UCECchr5133980892Missense_MutationnovelD130N0.35
UCECchr51339721713'UTRnovel0.38
UCECchr51339719413'UTRnovel0.43
UCECchr51339726853'UTRnovel0.5
UCECchr5133991008Missense_MutationnovelE88D0.38
UCECchr51339721713'UTRnovel0.5
UCECchr5133992956SilentnovelT19T0.21
UCECchr5133972856Missense_MutationnovelK256T0.44
UCECchr5133975915Missense_MutationnovelG220R0.43
UCECchr51339721703'UTRnovel0.36
UCECchr51339721713'UTRnovel0.51
UCECchr5133992346Missense_MutationnovelL26S0.59
UCECchr51339719303'UTRnovel0.46
UCECchr51339726023'UTRnovel0.36
UCECchr5133975960Missense_MutationnovelA205T0.28
UCECchr51339720163'UTRnovel0.29
UCECchr5133990857Splice_RegionnovelT107T0.43
UCECchr5133975922Silentrs542220207T217T0.15
UCECchr5133975921Missense_Mutationrs375779223R218C0.09
UCECchr5133972852SilentNAL257L0.08
UCECchr5133991062Silentrs201680896T70T0.24
UCECchr5133991107Silentrs556113860T55T0.44
UCECchr51339720153'UTRnovel0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.03820.11554
LAMLDEL0.0891.2971e-07
LUADDEL0.30817.4776e-05
LUSCDEL0.64270.002071
MESODEL0.14940.20184
PRADAMP0.03050.16448
STADDEL0.27442.8835e-08
THCAAMP0.03610.075436
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
KIRC0.0088

Kaplan-Meier Survival Analysis

SARC0.026

Kaplan-Meier Survival Analysis

MESO0.035

Kaplan-Meier Survival Analysis

HNSC0.00046

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

BRCA0.0032

Kaplan-Meier Survival Analysis

ESCA0.036

Kaplan-Meier Survival Analysis

COAD0.026

Kaplan-Meier Survival Analysis

PAAD0.015

Kaplan-Meier Survival Analysis

CESC0.031

Kaplan-Meier Survival Analysis

GBM0.001

Kaplan-Meier Survival Analysis

LIHC0.00018

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000213585 (Gene tree)
Gene ID
7416
Gene Symbol
VDAC1
Alias
MGC111064|PORIN
Full Name
voltage dependent anion channel 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
33,515 bases
Position
chr5:133,971,875-134,005,389
Accession
12669
RBP type
non-canonical RBP
Summary
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30209975Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.Autophagy2019 JanYau WWdoi: 10.1080/15548627.2018.1511263
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000425992VDAC1-204703-ENSP00000390129183 (aa)-C9JI87
ENST00000466080VDAC1-205831--- (aa)--
ENST00000395044VDAC1-2021807XM_017009821ENSP00000378484283 (aa)XP_016865310P21796
ENST00000265333VDAC1-2011953XM_005272075ENSP00000265333283 (aa)XP_005272132P21796
ENST00000395047VDAC1-2031873-ENSP00000378487283 (aa)-P21796
ENST00000489906VDAC1-206694--- (aa)--
ENST00000492324VDAC1-207635--- (aa)--
Gene Model
Click here to download ENSG00000213585's gene model file
Pathways
Pathway IDPathway NameSource
hsa04020Calcium signaling pathwayKEGG
hsa04022cGMP-PKG signaling pathwayKEGG
hsa04217NecroptosisKEGG
hsa04218Cellular senescenceKEGG
hsa04621NOD-like receptor signaling pathwayKEGG
hsa04979Cholesterol metabolismKEGG
hsa05012Parkinson diseaseKEGG
hsa05016Huntington diseaseKEGG
hsa05164Influenza AKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000213585Platelet Function Tests1.8990500E-005-
ENSG00000213585Multiple Sclerosis6E-721833088
ENSG00000213585Lupus Erythematosus, Systemic4E-1027399966
ENSG00000213585Lupus Erythematosus, Systemic7E-1026502338
ENSG00000213585Lupus Erythematosus, Systemic4E-1626502338
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000213585's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000213585VDAC19840.659WBGene00019900vdac-19840.357Caenorhabditis_elegans
ENSG00000213585VDAC110074.558ENSG00000165637VDAC29674.908Homo_sapiens
ENSG00000213585VDAC110098.587ENSMUSG00000020402Vdac110098.587Mus_musculus
ENSG00000213585VDAC110074.205ENSMUSG00000021771Vdac210074.205Mus_musculus
ENSG00000213585VDAC110067.491ENSMUSG00000008892Vdac310067.491Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001662behavioral fear response-IEAProcess
GO:0005515protein binding9843949.21370995.23055042.25296756.25556234.26387735.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005739mitochondrion20833797.HDAComponent
GO:0005741mitochondrial outer membrane21873635.IBAComponent
GO:0005741mitochondrial outer membrane17008324.25244949.IDAComponent
GO:0005741mitochondrial outer membrane-TASComponent
GO:0005757mitochondrial permeability transition pore complex26387735.IDAComponent
GO:0005886plasma membrane25296756.IDAComponent
GO:0006090pyruvate metabolic process-TASProcess
GO:0006820anion transport8420959.IDAProcess
GO:0006851mitochondrial calcium ion transmembrane transport-IEAProcess
GO:0006915apoptotic process25296756.IDAProcess
GO:0006915apoptotic process10365962.TASProcess
GO:0007270neuron-neuron synaptic transmission-IEAProcess
GO:0007612learning-IEAProcess
GO:0008021synaptic vesicle-IEAComponent
GO:0008308voltage-gated anion channel activity21873635.IBAFunction
GO:0008308voltage-gated anion channel activity8420959.IDAFunction
GO:0008308voltage-gated anion channel activity-ISSFunction
GO:0008308voltage-gated anion channel activity-TASFunction
GO:0015288porin activity-IEAFunction
GO:0015698inorganic anion transport-IEAProcess
GO:0016020membrane-ISSComponent
GO:0016032viral process-IEAProcess
GO:0016236macroautophagy-TASProcess
GO:0019901protein kinase binding21370995.IPIFunction
GO:0030855epithelial cell differentiation21492153.IEPProcess
GO:0042645mitochondrial nucleoid18063578.IDAComponent
GO:0044325ion channel binding25296756.IPIFunction
GO:0044877protein-containing complex binding-IEAFunction
GO:0045121membrane raft-IEAComponent
GO:0046930pore complex9843949.TASComponent
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0098656anion transmembrane transport-IEAProcess
GO:1903146regulation of autophagy of mitochondrion20098416.NASProcess
GO:2000378negative regulation of reactive oxygen species metabolic process-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us