EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
12425757Expression and regulation of tumor suppressor gene maspin in breast cancer.Clin Breast Cancer2002 OctMaass N-
26208903Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity.Cancer Res2015 Sep 15Bernardo MMdoi: 10.1158/0008-5472.CAN-15-0234
20337574The natural tumor suppressor protein maspin and potential application in non small cell lung cancer.Curr Pharm Des2010 JunLonardo F-
24581141Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells.BMC Cancer2014 Feb 28Machowska Mdoi: 10.1186/1471-2407-14-142.
25973084Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer.Int J Clin Exp Pathol2015 Feb 1Kim JH-
23924927Reactive center loop moiety is essential for the maspin activity on cellular invasion and ubiquitin-proteasome level.Oncol Res2013Khanaree Cdoi: 10.3727/096504013X13657689383175.
19221500PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells.Cell Cycle2009 Mar 15Eitel JA-
28011488Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases.Anticancer Res2017 JanStrien L-
24030740Maspin expression and melanoma progression: a matter of sub-cellular localization.Mod Pathol2014 MarMartinoli Cdoi: 10.1038/modpathol.2013.157
26526579Mammary serine protease inhibitor and CD138 immunohistochemical expression in ovarian serous and clear cell carcinomas.Tumour Biol2016 AprHasby EAdoi: 10.1007/s13277-015-4333-y
19147537Focused PCR screen reveals p53 dependence of nitric oxide-induced apoptosis and up-regulation of maspin and plasminogen activator inhibitor-1 in tumor cells.Mol Cancer Res2009 JanLim Sdoi: 10.1158/1541-7786.MCR-08-0331.
21187389Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype.Proc Natl Acad Sci U S A2011 Jan 11Villares GJdoi: 10.1073/pnas.1006886108
12384513Maspin inhibits cell migration in the absence of protease inhibitory activity.J Biol Chem2002 Dec 6Bass R-
15353310The promise and challenge toward the clinical application of maspin in cancer.Front Biosci2004 Sep 1Sheng S-
16540429Maspin and tumor metastasis.IUBMB Life2006 JanChen EI-
15713631Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition.Mol Cell Biol2005 MarLatha K-
19728335High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.Int J Cancer2010 Mar 1Jiang Rdoi: 10.1002/ijc.24854.
15688005Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis.Oncogene2005 Mar 17Li Z-
26614844Tumor suppressor maspin as a modulator of host immune response to cancer.Bosn J Basic Med Sci2015 Oct 25Dzinic SHdoi: 10.17305/bjbms.2015.783.
19222699The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis.J Cutan Pathol2009 NovFontes Adoi: 10.1111/j.1600-0560.2009.01243.x
22825520Predictive value of maspin and Ki-67 expression in transurethral resection specimens in patients with T1 bladder cancer.Tumori2012 May-JunAcikalin Ddoi: 10.1700/1125.12403.
11751384Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin.Cancer Res2001 Dec 15Biliran H Jr-
18367129Maspin reduces prostate cancer metastasis to bone.Urol Oncol2008 Nov-DecHall DCdoi: 10.1016/j.urolonc.2007.07.017
15578720TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor.Int J Cancer2005 Apr 20Spiesbach K-
21622623HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells.Mol Cancer Res2011 JunLi Xdoi: 10.1158/1541-7786.MCR-10-0505
20211623Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells.FEBS Lett2010 Apr 16Yeom SYdoi: 10.1016/j.febslet.2010.02.072
18698492Maspin polymorphism associated with apoptosis susceptibility and in vivo tumorigenesis.Int J Mol Med2008 SepJang HL-
17301947Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.Cell Motil Cytoskeleton2007 MayShi HY-
16614520Clinicopathological significance of maspin expression in breast cancer.J Korean Med Sci2006 AprLee MJ-
12533266Toward re-expressing tumor suppresor gene maspin in breast cancer.Clin Breast Cancer2002 DecZhang M-
15760906The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.J Biol Chem2005 Jun 10Law RH-
16892558[Role of the class II tumor suppressor gene maspin in thyroid carcinogenesis].Verh Dtsch Ges Pathol2004Boltze C-
15907209Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins.BMC Cancer2005 May 20Zhang W-
14534696Maspin in thyroid cancer: its relationship with p53 and clinical outcome.Oncol Rep2003 Nov-DecBoltze C-
21502940Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis.Lab Invest2011 AugGoulet Bdoi: 10.1038/labinvest.2011.66
28009978The secretion and biological function of tumor suppressor maspin as an exosome cargo protein.Oncotarget2017 Jan 31Dean Idoi: 10.18632/oncotarget.13302.
15620951Prognostic significance of the tumor suppressor gene maspin in non-small cell lung cancer.Ann Thorac Surg2005 JanHirai K-
12644823Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas.Br J Cancer2003 Mar 24Bi??che I-
14732229Expression and regulation of tumor suppressor gene maspin in human bladder cancer.Cancer Lett2004 Jan 20Sugimoto S-
21903246The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.Gynecol Oncol2011 NovAlvarez Secord Adoi: 10.1016/j.ygyno.2011.08.003
29126758Maspin expression and subcellular localization in invasive ductal carcinoma of the breast: Prognostic significance and relation to microvessel density.J Egypt Natl Canc Inst2017 DecHelal DSdoi: 10.1016/j.jnci.2017.09.002
21330826Highly increased maspin expression corresponds with up-regulation of miR-21 in endometrial cancer: a preliminary report.Int J Gynecol Cancer2011 JanTorres Adoi: 10.1097/IGC.0b013e318200050e.
14578190Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells.Am J Pathol2003 NovAkiyama Y-
22780967[NF-??B subunits regulate maspin expression in prostate cancer cells in vitro].Zhonghua Zhong Liu Za Zhi2012 MarMa Ldoi: 10.3760/cma.j.issn.0253-3766.2012.03.002.
18247378Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.Mol Carcinog2008 OctYamaguchi Hdoi: 10.1002/mc.20423.
24242003Maspin influences response to doxorubicin by changing the tumor microenvironment organization.Int J Cancer2014 Jun 15Triulzi Tdoi: 10.1002/ijc.28608
17458898Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells.J Cell Physiol2007 AugLi X-
19909580Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status.Neurol Res2010 AprStark AMdoi: 10.1179/016164109X12518779082192
16491398The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer.J Cancer Res Clin Oncol2006 JunGirish GV-
21439064Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis.J Exp Clin Cancer Res2011 Mar 25Lin Zdoi: 10.1186/1756-9966-30-31.
20099971Maspin and Nm23-H1 expression in colorectal cancer.Neoplasma2010Pasz-Walczak G-
23922175Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression.Tumour Biol2014 JanWu CTdoi: 10.1007/s13277-013-1024-4
19462894[Expression of maspin and its relation to tumor vascularization in epithelian ovarian cancer].Sichuan Da Xue Xue Bao Yi Xue Ban2009 MarMa Y-
14991928Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer.World J Gastroenterol2004 Mar 1Wang MC-
12789271Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.Oncogene2003 Jun 5Oshiro MM-
17446556Proteomics demonstration that normal breast epithelial cells can induce apoptosis of breast cancer cells through insulin-like growth factor-binding protein-3 and maspin.Mol Cell Proteomics2007 JulToillon RA-
16633061Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates.Int J Gynecol Pathol2006 AprSurowiak P-
26490978Maspin mediates the gemcitabine sensitivity of hormone-independent prostate cancer.Tumour Biol2016 MarHuang CYdoi: 10.1007/s13277-015-4083-x
12220518Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.Biochem Biophys Res Commun2002 Sep 13Maass N-
24002600Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer.Br J Cancer2013 Sep 17Snoeren Ndoi: 10.1038/bjc.2013.489
22962304Maspin genetically and functionally associates with gastric cancer by regulating cell cycle progression.Carcinogenesis2012 DecKim Mdoi: 10.1093/carcin/bgs280
20132554Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.BMC Cancer2010 Feb 4Wu Ydoi: 10.1186/1471-2407-10-32.
23818344Estimation of maspin's subcellular localization in invasive ductal breast cancer via light microscopy and computerized image analysis: a comparative study.J BUON2013 Apr-JunPanou M-
17203179Expression of maspin in endometrioid adenocarcinoma of endometrium.Oncol Rep2007 FebLi HW-
15256060Aberrant methylation of the maspin promoter is an early event in human breast cancer.Neoplasia2004 Jul-AugFutscher BW-
25936422VEGF-C inhibition reverses resistance of bladder cancer cells to cisplatin via upregulating maspin.Mol Med Rep2015 AugZhu Hdoi: 10.3892/mmr.2015.3684
18060631Effects of 5-Aza-CdR on cell proliferation of breast cancer cell line MDA-MB-435S and expression of maspin gene.J Huazhong Univ Sci Technolog Med Sci2007 OctZhang B-
12629351Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer.J Urol2003 AprChen Z-
12753703[Proteomics-based identification of Maspin differential expression in bronchial epithelial immortalized cells and malignant transformation cells].Ai Zheng2003 MayXie L-
24607789Re-expression and epigenetic modification of maspin induced apoptosis in MCF-7 cells mediated by myocardin.Cell Signal2014 JunLiao XHdoi: 10.1016/j.cellsig.2014.03.001
16007219Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis.Oncogene2005 Aug 11Tahmatzopoulos A-
18091326Maspin and p53 protein expression in gastric adenocarcinoma and its clinical applications.Appl Immunohistochem Mol Morphol2008 JanLee DY-
20334895Shift from cytoplasmic to nuclear maspin expression correlates with shorter overall survival in node-negative colorectal cancer.Hum Pathol2010 JulMrkl Bdoi: 10.1016/j.humpath.2009.10.021
26733306Maspin enhances cisplatin chemosensitivity in bladder cancer T24 and 5637 cells and correlates with prognosis of muscle-invasive bladder cancer patients receiving cisplatin based neoadjuvant chemotherapy.J Exp Clin Cancer Res2016 Jan 6Chen Jdoi: 10.1186/s13046-015-0282-y.
19073519Expression of maspin in non-small-cell lung cancer: correlation with clinical features.Clin Lung Cancer2008 NovTakanami Idoi: 10.3816/CLC.2008.n.052.
18931702Maspin modulates prostate cancer cell apoptotic and angiogenic response to hypoxia via targeting AKT.Oncogene2008 Dec 4McKenzie Sdoi: 10.1038/onc.2008.321
27525723Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence.PLoS One2016 Aug 15Yang PYdoi: 10.1371/journal.pone.0160841
28339463Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks.PLoS One2017 Mar 24Tsai HTdoi: 10.1371/journal.pone.0163369
28870936Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer.Anticancer Res2017 SepWakahara M-
29511373SERPINB5 Expression: Association with CCRT Response and Prognostic Value in Rectal Cancer.Int J Med Sci2018 Feb 12Chang IWdoi: 10.7150/ijms.22823
30035819Maspin mRNA expression in sentinel lymph nodes predicts non-SLN metastasis in breast cancer patients with SLN metastasis.Histopathology2018 DecUmekita Ydoi: 10.1111/his.13718

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1863503667Missense_MutationnovelI358T0.05
BLCAchr1863486952Missense_MutationnovelH59D0.14
BLCAchr1863499128SilentnovelT192T0.19
BLCAchr1863503519Missense_MutationNAE309Q0.35
BLCAchr1863493208Intronnovel0.38
BLCAchr1863484454Missense_Mutationrs374163653S9L0.34
BRCAchr1863503375Missense_MutationnovelP261A0.79
BRCAchr1863487048Missense_MutationNAR91W0.1
CESCchr18635037683'UTRnovel0.18
COADchr1863499217Frame_Shift_DelNAN223Ifs*590.37
COADchr1863499132Missense_MutationnovelP194A0.6
COADchr1863493138Intronnovel0.16
COADchr1863503536In_Frame_InsnovelA314_L315insMV0.13
ESCAchr1863484422Splice_Regionnovel0.22
GBMchr1863493068Frame_Shift_DelnovelE182Nfs*160.05
GBMchr1863486977Frame_Shift_InsnovelF68Sfs*70.07
GBMchr1863503715Missense_MutationnovelS374F0.18
GBMchr1863489423Missense_MutationNAT128M0.23
GBMchr18635038183'UTRnovel0.38
GBMchr1863499269SilentnovelE239E0.2
GBMchr1863486947Frame_Shift_DelnovelL58Ffs*160.31
GBMchr1863503370Missense_MutationnovelT259I0.18
GBMchr18635037983'UTRnovel0.24
HNSCchr1863487053SilentnovelL92L0.24
KIRCchr1863486982Missense_MutationNAG69R0.14
KIRCchr1863486946Missense_Mutationrs766152603V57L0.11
KIRCchr1863487003Missense_MutationNAD76N0.38
LAMLchr1863497307IntronNA0.42
LGGchr1863493153Intronnovel0.46
LUADchr1863503482SilentNAI296I0.14
LUADchr1863487048Missense_MutationNAR91W0.07
LUADchr1863493021Missense_MutationNAA165T0.37
LUADchr1863503576Missense_MutationnovelE328Q0.18
LUADchr1863499184Missense_MutationNAS211N0.13
LUADchr1863503437Missense_MutationnovelM281I0.1
LUADchr1863503329Splice_SitenovelX246_splice0.15
LUADchr1863487029Nonsense_MutationNAY84*0.64
LUADchr1863493164Intronnovel0.13
LUADchr1863503398Missense_MutationnovelK268N0.17
LUADchr1863493181Intronnovel0.35
LUADchr18635038643'UTRnovel0.46
LUSCchr1863487053SilentnovelL92L0.31
LUSCchr1863499206Missense_MutationnovelE218D0.14
LUSCchr1863493044Missense_MutationNAM172I0.21
LUSCchr1863484591Nonsense_MutationnovelG55*0.29
LUSCchr1863484592Missense_Mutationrs753774243G55V0.3
LUSCchr1863493034Missense_MutationNAG169A0.38
LUSCchr1863489424Silentrs757336116T128T0.36
LUSCchr1863503541Nonsense_MutationnovelS316*0.35
OVchr1863503466Missense_MutationnovelL291R0.05
OVchr1863503468Frame_Shift_InsnovelG292Afs*80.05
OVchr1863487003Missense_MutationNAD76N0.3
OVchr1863493124Intronnovel0.07
OVchr1863503513Missense_MutationNAM307L0.25
PAADchr1863489447Missense_MutationnovelI136T0.5
PRADchr1863489452Missense_MutationnovelD138Y0.09
PRADchr1863493052Missense_MutationNAF175S0.22
PRADchr1863503379Missense_MutationnovelS262N0.3
READchr1863493047Missense_MutationNAK173N0.43
SARCchr18635039153'UTRnovel0.54
SKCMchr1863492991Missense_MutationnovelD155N0.27
SKCMchr1863493181Intronnovel0.6
SKCMchr1863499223Missense_MutationNAK224R0.45
SKCMchr1863493255Intronnovel0.4
SKCMchr1863493198Intronnovel0.36
SKCMchr1863489455Missense_MutationnovelL139F0.28
SKCMchr1863486958Missense_MutationNAE61K0.29
SKCMchr1863489364Silentrs141561710T108T0.1
SKCMchr1863503567Missense_MutationNAE325K0.3
SKCMchr1863499255Missense_MutationnovelD235N0.43
SKCMchr1863484585Missense_MutationNAE53K0.38
SKCMchr1863503641Missense_MutationnovelN349K0.32
SKCMchr1863493187Intronnovel0.3
SKCMchr1863489419Missense_MutationNAE127K0.41
SKCMchr1863493129Intronnovel0.39
SKCMchr18635038043'UTRnovel0.34
SKCMchr1863486977Missense_Mutationrs375704233P67L0.14
SKCMchr1863493079Missense_MutationNAP184L0.08
SKCMchr1863499287Splice_RegionnovelK245K0.27
SKCMchr1863487060Missense_MutationnovelD95N0.85
SKCMchr1863493079Missense_MutationNAP184L0.08
SKCMchr1863499223Missense_MutationNAK224R0.53
SKCMchr1863489382SilentnovelK114K0.29
STADchr1863489465Splice_SiteNAX142_splice0.35
STADchr1863487002Silentrs772139907S75S0.31
STADchr1863503638Missense_MutationNAL348F0.41
UCECchr1863489424Silentrs757336116T128T0.29
UCECchr1863503609Missense_MutationNAA339T0.38
UCECchr1863484573Missense_MutationNAD49N0.25
UCECchr1863489392Missense_MutationnovelT118P0.36
UCECchr18635040393'UTRnovel0.35
UCECchr1863484473SilentnovelL15L0.18
UCECchr1863486970Missense_MutationnovelD65Y0.08
UCECchr1863489369Missense_MutationNAR110I0.49
UCECchr18635041073'UTRnovel0.28
UCECchr18635038843'UTRnovel0.3
UCECchr18635037693'UTRrs7736906400.42
UCECchr1863503359SilentnovelL255L0.39
UCECchr1863499254Missense_MutationnovelK234N0.43
UCECchr1863503698Silentrs267605224F368F0.7
UCECchr18635038963'UTRnovel0.22
UCECchr18635037693'UTRrs7736906400.2
UCECchr18635042273'UTRnovel0.53
UCECchr1863486970Missense_MutationnovelD65Y0.35
UCECchr1863503486Missense_MutationnovelS298R0.37
UCECchr1863493187Intronnovel0.48
UCECchr1863493188Intronnovel0.13
UCECchr1863493189Intronnovel0.13
UCECchr1863493072Nonsense_MutationnovelE182*0.34
UCECchr1863503609Missense_MutationNAA339T0.46
UCECchr18635040393'UTRnovel0.28
UCSchr1863499172Missense_MutationnovelG207E0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.37752.627e-05
DLBCAMP0.35420.065049
ESCADEL0.53261.0131e-05
LIHCDEL0.2270.019373
PRADDEL0.24190.001136
UCECDEL0.16140.006131
UCSDEL0.3750.12533

Survival Analysis
CancerP-value Q-value
KIRC0.00031

Kaplan-Meier Survival Analysis

MESO0.00021

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

BRCA0.0035

Kaplan-Meier Survival Analysis

PAAD0.0001

Kaplan-Meier Survival Analysis

UCEC0.035

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

OV0.047

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000206075 (Gene tree)
Gene ID
5268
Gene Symbol
SERPINB5
Alias
maspin|PI5
Full Name
serpin family B member 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
28,325 bases
Position
chr18:63,476,761-63,505,085
Accession
8949
RBP type
non-canonical RBP
Summary
(Serpin Family B Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include Syringoma and Bone Squamous Cell Carcinoma. Among its related pathways are ATF-2 transcription factor network and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22646265Reevaluation and identification of the best immunohistochemical panel (pVHL, Maspin, S100P, IMP-3) for ductal adenocarcinoma of the pancreas.Arch Pathol Lab Med2012 JunLiu Hdoi: 10.5858/arpa.2011-0326-OA.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000588986SERPINB5-206524--- (aa)--
ENST00000464346SERPINB5-203485--- (aa)--
ENST00000424602SERPINB5-202560-ENSP00000408821129 (aa)-C9JLM5
ENST00000382771SERPINB5-2012783-ENSP00000372221375 (aa)-P36952
ENST00000465652SERPINB5-204454--- (aa)--
ENST00000489441SERPINB5-2051268-ENSP00000467158231 (aa)-P36952
Gene Model
Click here to download ENSG00000206075's gene model file
Pathways
Pathway IDPathway NameSource
hsa04115p53 signaling pathwayKEGG
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000206075Platelet Function Tests4.8319180E-006-
ENSG00000206075Testosterone3.8280000E-005-
ENSG00000206075Testosterone4.2920000E-005-
ENSG00000206075Testosterone4.8620000E-005-
ENSG00000206075Electrocardiography3E-624324551
ENSG00000206075Trypanosoma cruzi3E-624324551
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000206075rs792853311863478474?PR interval in Tripanosoma cruzi seropositivity24324551EFO_0004462|EFO_0005530
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000206075's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000206075SERPINB510093.023ENSMUSG00000067006Serpinb510089.067Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002009morphogenesis of an epithelium-IEAProcess
GO:0004867serine-type endopeptidase inhibitor activity21873635.IBAFunction
GO:0005515protein binding16049006.20211623.IPIFunction
GO:0005615extracellular space21873635.IBAComponent
GO:0005737cytoplasm16049006.IDAComponent
GO:0010951negative regulation of endopeptidase activity21873635.IBAProcess
GO:0030198extracellular matrix organization-IEAProcess
GO:0050678regulation of epithelial cell proliferation-IEAProcess
GO:0060512prostate gland morphogenesis-IEAProcess
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