EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20821256Actin-sequestering protein, thymosin beta-4, is a novel hypoxia responsive regulator.Clin Exp Metastasis2010 DecMoon EYdoi: 10.1007/s10585-010-9350-z
17567947Subcellular distribution of thymosin beta4.Ann N Y Acad Sci2007 SepZoubek RE-
23235961Immunohistochemical expression of thymosin β4 in ameloblastomas and odontomas.Histol Histopathol2013 JunKiyoshima Tdoi: 10.14670/HH-28.775
27521796Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation.Acta Biochim Biophys Sin (Shanghai)2016 SepHuang Ddoi: 10.1093/abbs/gmw070
28831179Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.Sci Rep2017 Aug 22Chi LHdoi: 10.1038/s41598-017-09539-w.
25218472Thymosin β4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/β-catenin signaling pathway.Biochem Biophys Res Commun2014 Sep 26Piao Zdoi: 10.1016/j.bbrc.2014.09.012
18094619Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation.Cancer Biol Ther2008 MarZhang Y-
20566622Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells.FASEB J2010 NovRicci-Vitiani Ldoi: 10.1096/fj.10-159970
22328534Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.Int J Cancer2012 Nov 1Ryu YKdoi: 10.1002/ijc.27490
21109953Thymosin β4 expression correlates with lymph node metastasis through hypoxia inducible factor-α induction in breast cancer.Oncol Rep2011 JanYoon SY-
23045970Thymosin β4 expression reveals intriguing similarities between fetal and cancer cells.Ann N Y Acad Sci2012 OctFaa Gdoi: 10.1111/j.1749-6632.2012.06679.x.
16949646Occurrence of thymosin beta4 in human breast cancer cells and in other cell types of the tumor microenvironment.Hum Pathol2007 JanLarsson LI-
26556858MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.Oncotarget2015 Dec 22Gemoll Tdoi: 10.18632/oncotarget.6103.
20691219Thymosin β4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1α-dependent manner.Biochim Biophys Acta2010 NovJo JOdoi: 10.1016/j.bbamcr.2010.07.005

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchrX129768613'UTRnovel0.14
BLCAchrX129769143'UTRnovel0.75
CESCchrX12976301Missense_MutationNAD14N0.24
CESCchrX129768503'UTRnovel0.08
CESCchrX129768523'UTRnovel0.08
COADchrX129771923'Flanknovel0.42
COADchrX129769393'UTRnovel0.5
COADchrX12976284Missense_Mutationrs777121308A8V0.09
COADchrX129770623'UTRnovel0.05
DLBCchrX12976288Missense_MutationnovelE9D0.68
DLBCchrX12976283Missense_MutationnovelA8P0.26
DLBCchrX12976286In_Frame_DelnovelI10_E11del0.25
DLBCchrX12976794Nonsense_MutationNAQ40*0.65
DLBCchrX12976793SilentnovelK39K0.32
DLBCchrX12976245Splice_Sitenovel0.68
DLBCchrX12976275Missense_MutationnovelP5R0.06
DLBCchrX12976362Splice_SitenovelX34_splice0.14
GBMchrX12976308Missense_MutationnovelS16L0.33
HNSCchrX129768503'UTRnovel0.08
HNSCchrX129768523'UTRnovel0.06
LIHCchrX129751415'Flanknovel0.75
LUADchrX129768123'UTRnovel0.22
LUSCchrX129762515'UTRnovel0.2
LUSCchrX129768733'UTRnovel0.14
LUSCchrX12976300Missense_MutationnovelF13L0.11
LUSCchrX129768203'UTRnovel0.69
MESOchrX129768283'UTRnovel0.67
OVchrX129769053'UTRnovel0.47
OVchrX129768703'UTRnovel0.1
OVchrX12976258Missense_MutationnovelM1_?50.07
SARCchrX129768593'UTRnovel0.48
SARCchrX129768603'UTRnovel0.48
SKCMchrX12976334Missense_MutationnovelE25K0.25
STADchrX12976330SilentNAT23T0.41
THCAchrX129768503'UTRnovel0.03
THCAchrX129768503'UTRnovel0.06
THCAchrX129768523'UTRnovel0.04
UCECchrX129768513'UTRnovel0.5
UCECchrX129769643'UTRnovel0.41
UCECchrX12976291SilentnovelI10I0.2
UCECchrX129768653'UTRnovel0.26
UCECchrX129771493'Flanknovel0.88
UCECchrX129771493'Flanknovel0.35
UCECchrX129769643'UTRnovel0.48
UCECchrX129768733'UTRnovel0.42
UCECchrX129768613'UTRnovel0.34
UCECchrX129771493'Flanknovel0.39
UCECchrX129768393'UTRnovel0.27
UCECchrX129771493'Flanknovel0.25
UCECchrX129771253'Flanknovel0.15
UCECchrX129769383'UTRnovel0.2
UCECchrX129768733'UTRrs170088830.37
UCECchrX129769063'UTRnovel0.37
UCECchrX12976291SilentnovelI10I0.05
UCECchrX129768953'UTRnovel0.41
UCECchrX12976243Splice_Regionrs7731784350.33
UCECchrX12976344Missense_MutationnovelP28Q0.31
UCECchrX129768573'UTRnovel0.39

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
READAMP0.09090.13718
SARCAMP0.26070.19108
THCADEL0.0020.21991

Survival Analysis
CancerP-value Q-value
THYM0.024

Kaplan-Meier Survival Analysis

KIRC0.0077

Kaplan-Meier Survival Analysis

STAD0.016

Kaplan-Meier Survival Analysis

HNSC0.026

Kaplan-Meier Survival Analysis

SKCM0.00011

Kaplan-Meier Survival Analysis

ESCA0.0086

Kaplan-Meier Survival Analysis

COAD0.00042

Kaplan-Meier Survival Analysis

PAAD0.034

Kaplan-Meier Survival Analysis

PCPG0.035

Kaplan-Meier Survival Analysis

UCEC0.0014

Kaplan-Meier Survival Analysis

LIHC0.0066

Kaplan-Meier Survival Analysis

LUAD0.00081

Kaplan-Meier Survival Analysis

UVM0.0036

Kaplan-Meier Survival Analysis

OV0.0098

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000205542 (Gene tree)
Gene ID
7114
Gene Symbol
TMSB4X
Alias
TB4X|TMSB4
Full Name
thymosin beta 4 X-linked
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
2,121 bases
Position
chrX:12,975,107-12,977,227
Accession
11881
RBP type
non-canonical RBP
Summary
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000451311TMSB4X-204628-ENSP0000041437644 (aa)-P62328
ENST00000380633TMSB4X-201495-ENSP0000037000744 (aa)-P62328
ENST00000380635TMSB4X-202767-ENSP0000037000944 (aa)-P62328
ENST00000380636TMSB4X-2031702-ENSP0000037001044 (aa)-P62328
Gene Model
Click here to download ENSG00000205542's gene model file
Pathways
Pathway IDPathway NameSource
hsa04810Regulation of actin cytoskeletonKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000205542's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000205542TMSB4X100100.000ENSMUSG00000049775Tmsb4x100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002576platelet degranulation-TASProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0003785actin monomer binding21873635.IBAFunction
GO:0003785actin monomer binding1447300.1999398.IDAFunction
GO:0005515protein binding17967441.20706999.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21343177.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm21343177.IDAComponent
GO:0005829cytosol1447300.IDAComponent
GO:0005856cytoskeleton-IEAComponent
GO:0007015actin filament organization-IEAProcess
GO:0007253cytoplasmic sequestering of NF-kappaB21343177.IMPProcess
GO:0019899enzyme binding21106936.IPIFunction
GO:0030334regulation of cell migration21873635.IBAProcess
GO:0031093platelet alpha granule lumen-TASComponent
GO:0032088negative regulation of NF-kappaB transcription factor activity21343177.IMPProcess
GO:0033209tumor necrosis factor-mediated signaling pathway21343177.IMPProcess
GO:0042989sequestering of actin monomers21873635.IBAProcess
GO:0042989sequestering of actin monomers1447300.1999398.IDAProcess
GO:0043536positive regulation of blood vessel endothelial cell migration21106936.IDAProcess
GO:0043536positive regulation of blood vessel endothelial cell migration21106936.IGIProcess
GO:0050727regulation of inflammatory response21343177.IMPProcess
GO:1901222regulation of NIK/NF-kappaB signaling21343177.IGIProcess
GO:1901223negative regulation of NIK/NF-kappaB signaling21343177.IMPProcess
GO:1903026negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding21343177.IDAProcess
GO:1905273positive regulation of proton-transporting ATP synthase activity, rotational mechanism21106936.IDAProcess
GO:2000483negative regulation of interleukin-8 secretion21343177.IDAProcess
GO:2001028positive regulation of endothelial cell chemotaxis21106936.IDAProcess
GO:2001171positive regulation of ATP biosynthetic process21106936.IDAProcess
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