EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22240482RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex.Gastroenterology2012 AprDeng YZdoi: 10.1053/j.gastro.2011.12.046
24481459Silencing the receptor of activated C-kinase 1 (RACK1) suppresses tumorigenicity in epithelial ovarian cancer in vitro and in vivo.Int J Oncol2014 AprLin Ydoi: 10.3892/ijo.2014.2274
21848913Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis.Cancer Sci2011 NovWang Fdoi: 10.1111/j.1349-7006.2011.02065.x
19892429Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas.Lung Cancer2010 JulNagashio Rdoi: 10.1016/j.lungcan.2009.09.015
26199092Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop.Cancer Res2015 Sep 15Chen Ldoi: 10.1158/0008-5472.CAN-14-3690
15548575Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone.J Leukoc Biol2005 FebCorsini E-
27453417Receptor for activated protein kinase C 1 suppresses gastric tumor progression through nuclear factor-kB pathway.Indian J Cancer2015 DecYong-Zheng Xdoi: 10.4103/0019-509X.186572.
26893362RACK1 overexpression is linked to acquired imatinib resistance in gastrointestinal stromal tumor.Oncotarget2016 Mar 22Gao Xdoi: 10.18632/oncotarget.7426.
25686824RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer.Oncotarget2015 Feb 28Choi YY-
18420585RACK1 and CIS mediate the degradation of BimEL in cancer cells.J Biol Chem2008 Jun 13Zhang Wdoi: 10.1074/jbc.M802360200
25065497Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2 -independent and RACK1-mediated mechanism of HIF-1α stabilization.J Pathol2014 DecYu Sdoi: 10.1002/path.4413
20020495RACK1: A superior independent predictor for poor clinical outcome in breast cancer.Int J Cancer2010 Sep 1Cao XXdoi: 10.1002/ijc.25120.
22314363EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.Nat Commun2012 Feb 7Li Gdoi: 10.1038/ncomms1675.
23912224RACK1 promotes prostate cancer cell proliferation, invasion and metastasis.Mol Med Rep2013 OctShen Fdoi: 10.3892/mmr.2013.1612
28760343RACK1 promotes radiation resistance in esophageal cancer via regulating AKT pathway and Bcl-2 expression.Biochem Biophys Res Commun2017 Sep 23Liu Bdoi: 10.1016/j.bbrc.2017.07.153
28418088RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.Mol Carcinog2017 NovZhou Cdoi: 10.1002/mc.22663
28797110GNB2L1 and its O-GlcNAcylation regulates metastasis via modulating epithelial-mesenchymal transition in the chemoresistance of gastric cancer.PLoS One2017 Aug 10Cheng Sdoi: 10.1371/journal.pone.0182696
26863570Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.Oncotarget2016 May 24Guo Xdoi: 10.18632/oncotarget.7217.
27600565RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells.Cell Signal2017 JulKiely Mdoi: 10.1016/j.cellsig.2016.09.001
29048616The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer.Int J Oncol2017 NovLiao Sdoi: 10.3892/ijo.2017.4137

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5181238127Missense_MutationnovelA250G0.5
BLCAchr5181239172Nonsense_MutationnovelW177*0.49
BLCAchr5181241651Intronnovel0.44
BLCAchr5181241545Missense_MutationnovelD126H0.15
BRCAchr5181239273Intronnovel0.12
BRCAchr5181238277Intronnovel0.1
BRCAchr5181242320SilentnovelL45L0.1
BRCAchr5181243769Missense_MutationnovelL11P0.04
BRCAchr5181238141SilentNAR245R0.18
BRCAchr5181237008Missense_MutationnovelR308P0.05
BRCAchr5181237279IntronNA0.17
BRCAchr5181238243Splice_Regionnovel0.17
BRCAchr5181239078Missense_MutationnovelS209A0.1
BRCAchr51812438225'UTRnovel0.15
BRCAchr5181241718Intronnovel0.29
BRCAchr5181239297Intronnovel0.21
BRCAchr5181239577SilentNAE145E0.22
BRCAchr5181242195Missense_MutationNAL87R0.25
BRCAchr5181239282Intronnovel0.25
BRCAchr5181241564Missense_MutationNAQ119H0.24
BRCAchr5181238834Intronnovel0.48
CESCchr5181242193Missense_MutationnovelR88C0.11
CESCchr5181242216Nonsense_MutationnovelS80*0.05
CESCchr5181238263Intronnovel0.08
CESCchr5181243716Missense_MutationnovelD29H0.14
COADchr5181237117Intronnovel0.19
COADchr5181239000Intronnovel0.55
COADchr5181239218Intronnovel0.05
COADchr5181241573SilentNAD116D0.31
COADchr5181239385Intronnovel0.42
COADchr5181242175Missense_MutationnovelT94A0.4
COADchr5181241722Intronnovel0.45
COADchr5181239252Intronnovel0.08
COADchr5181241638Missense_MutationNAG95S0.38
COADchr5181239517Silentrs139942873I165I0.35
ESCAchr5181242293Missense_MutationnovelI54M0.57
GBMchr5181243763Missense_MutationnovelG13D0.56
GBMchr5181239120Missense_MutationnovelL195M0.14
GBMchr5181241776Intronnovel0.16
GBMchr5181242000Intronnovel0.14
HNSCchr5181239087Missense_MutationNAL206F0.51
HNSCchr5181238348Intronnovel0.19
HNSCchr5181239085SilentnovelL206L0.05
HNSCchr5181241683Intronnovel0.07
HNSCchr5181238325Intronnovel0.16
HNSCchr5181238329Intronnovel0.63
HNSCchr5181241724Intronnovel0.07
KIRCchr51812438125'UTRnovel0.33
KIRPchr5181242131Intronnovel0.3
KIRPchr5181243768SilentnovelL11L0.28
KIRPchr51812438225'UTRnovel0.25
LAMLchr5181238328Intronnovel0.07
LGGchr5181238164Missense_MutationNAA238T0.09
LGGchr5181241728Intronnovel0.16
LGGchr5181242308Missense_MutationnovelE49D0.13
LIHCchr5181239567Missense_Mutationrs768541673E149Q0.46
LIHCchr5181239153Missense_MutationnovelL184M0.09
LIHCchr5181238320Intronnovel0.48
LIHCchr5181241673Intronnovel0.38
LIHCchr5181237157Intronnovel0.42
LUADchr5181238099Nonsense_MutationnovelW259*0.12
LUADchr5181241575Missense_MutationnovelD116N0.1
LUADchr5181243768SilentnovelL11L0.16
LUADchr5181239449Intronnovel0.79
LUADchr5181241496Missense_MutationNAV142A0.39
LUSCchr5181241580Missense_MutationnovelS114F0.31
LUSCchr5181241594SilentNAL109L0.26
LUSCchr5181239034Intronnovel0.17
LUSCchr5181242341Missense_MutationnovelK38N0.33
LUSCchr5181241995Intronnovel0.1
OVchr5181241542Missense_MutationnovelK127Q0.06
OVchr5181241617Missense_MutationnovelV102L0.08
OVchr5181241582Frame_Shift_InsnovelF113Lfs*730.15
OVchr5181239296Intronnovel0.11
PAADchr51812369373'UTRnovel0.18
PRADchr5181239064Splice_Regionnovel0.1
SARCchr5181243201Intronnovel0.08
SARCchr5181237689SilentnovelL270L0.13
SKCMchr5181237711SilentnovelE262E0.43
SKCMchr5181239403Intronnovel0.44
SKCMchr5181241528SilentnovelL131L0.4
SKCMchr5181241648Intronnovel0.21
SKCMchr5181241594SilentNAL109L0.28
SKCMchr5181241818Intronnovel0.16
SKCMchr5181238212Missense_MutationNAN222D0.49
SKCMchr5181241622Missense_MutationNAR100L0.42
SKCMchr5181238143Missense_MutationNAR245C0.46
STADchr5181237713Missense_MutationNAE262Q0.16
STADchr5181237659Missense_MutationNAK280E0.36
STADchr5181238164Missense_MutationNAA238T0.05
STADchr5181238900Intronnovel0.42
STADchr5181237118IntronNA0.22
STADchr5181241824Intronnovel0.46
STADchr5181239109SilentNAV198V0.19
STADchr5181237118IntronNA0.53
THCAchr5181241683Intronnovel0.08
THCAchr5181241684Intronnovel0.17
THCAchr5181241684Intronnovel0.08
THCAchr5181241685Intronnovel0.08
THCAchr5181241684Intronnovel0.09
THCAchr5181241685Intronnovel0.09
UCECchr5181239195Intronnovel0.49
UCECchr5181239574Missense_MutationNAS146R0.35
UCECchr5181238209Missense_MutationnovelE223K0.06
UCECchr5181241934Intronnovel0.25
UCECchr5181241526Missense_MutationnovelW132L0.25
UCECchr5181239248Intronnovel0.48
UCECchr5181243735SilentnovelA22A0.43
UCECchr5181242331Missense_MutationnovelM42V0.24
UCECchr5181239481Splice_Regionnovel0.44
UCECchr5181241725Intronnovel0.41
UCECchr5181241888Intronnovel0.39
UCECchr5181237117Intronnovel0.29
UCECchr5181241686Intronnovel0.23
UCECchr5181242337Missense_MutationnovelI40V0.17
UCECchr5181239296Intronnovel0.33
UCECchr5181239393Intronnovel0.36
UCECchr5181239194Intronnovel0.51
UCECchr5181241718Intronnovel0.29
UCECchr5181238102SilentNAI258I0.32
UCECchr5181241813Intronnovel0.12
UCECchr5181242193Missense_MutationnovelR88C0.38
UCECchr5181241931Intronnovel0.43
UCECchr5181237686Missense_MutationnovelK271E0.49
UCECchr5181237234Intronnovel0.18
UCECchr5181238883Intronnovel0.42
UCECchr5181237619Missense_MutationnovelA293D0.62
UCECchr5181239165Missense_MutationnovelA180T0.54
UCECchr5181239044Intronnovel0.43
UCECchr5181239112Silentrs754736780T197T0.31
UCECchr5181241623Nonsense_MutationnovelR100*0.41
UCECchr5181238349Intronnovel0.58

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.11460.069756
KIRPDEL0.03130.11554
LUADAMP0.17640.24967
LUSCDEL0.58680.002071
MESODEL0.11490.20184
PRADAMP0.03050.16448
SKCMAMP0.12530.23703
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
MESO0.047

Kaplan-Meier Survival Analysis

ACC0.016

Kaplan-Meier Survival Analysis

UCS0.021

Kaplan-Meier Survival Analysis

KIRP0.0044

Kaplan-Meier Survival Analysis

GBM0.0092

Kaplan-Meier Survival Analysis

LIHC0.00065

Kaplan-Meier Survival Analysis

LGG0.00087

Kaplan-Meier Survival Analysis

UVM0.022

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000204628 (Gene tree)
Gene ID
10399
Gene Symbol
RACK1
Alias
Gnb2-rs1|H12.3|GNB2L1
Full Name
receptor for activated C kinase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
11,188 bases
Position
chr5:181,236,909-181,248,096
Accession
4399
RBP type
non-canonical RBP
Summary
(Receptor For Activated C Kinase 1) is a Protein Coding gene. Diseases associated with RACK1 include Wells Syndrome. Among its related pathways are TNF signaling (REACTOME) and Regulation of CFTR activity (norm and CF).
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21771594Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery.FEBS Lett2011 Aug 19Goncalves Kde Adoi: 10.1016/j.febslet.2011.07.010
22123745The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes.Nucleic Acids Res2012 MarKouba Tdoi: 10.1093/nar/gkr1083
28267599The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1.Cell Signal2017 JulBolger GBdoi: 10.1016/j.cellsig.2017.03.001
18954305Structural basis and specificity of human otubain 1-mediated deubiquitination.Biochem J2009 Mar 1Edelmann MJdoi: 10.1042/BJ20081318.
18816594mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network.J Cell Biochem2008 Nov 1Choi Hdoi: 10.1002/jcb.21909.
23379559Proteins of the human 40S ribosomal subunit involved in hepatitis C IRES binding as revealed from fluorescent labeling.Biochemistry (Mosc)2013 JanMalygin AAdoi: 10.1134/S0006297913010069.
20871634Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness.Oncogene2011 Feb 3He Xdoi: 10.1038/onc.2010.427
24852294Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle.PLoS Pathog2014 May 22Li Qdoi: 10.1371/journal.ppat.1004163
26644407LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner.Mol Cell Biol2015 Dec 7Mattijssen Sdoi: 10.1128/MCB.00804-15
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000509148RACK1-221888-ENSP0000042465483 (aa)-H0Y9P0
ENST00000507261RACK1-215590--- (aa)--
ENST00000507000RACK1-214685-ENSP00000421416194 (aa)-D6RFX4
ENST00000510199RACK1-2231100-ENSP00000423569300 (aa)-D6R9L0
ENST00000504325RACK1-2101098-ENSP00000422198116 (aa)-D6R909
ENST00000503170RACK1-207461--- (aa)--
ENST00000514455RACK1-233791-ENSP00000426708101 (aa)-D6RF23
ENST00000507756RACK1-217889-ENSP00000422316274 (aa)-H0Y8W2
ENST00000376817RACK1-201965-ENSP00000366013273 (aa)-J3KPE3
ENST00000502890RACK1-204705--- (aa)--
ENST00000515417RACK1-234873--- (aa)--
ENST00000502548RACK1-2021090--- (aa)--
ENST00000506312RACK1-213559-ENSP0000042627071 (aa)-D6RGK8
ENST00000512805RACK1-2271403-ENSP00000426909317 (aa)-P63244
ENST00000504726RACK1-211388-ENSP0000042604686 (aa)-D6RHJ5
ENST00000511473RACK1-2241150-ENSP0000042093639 (aa)-D6RDI0
ENST00000507273RACK1-216358--- (aa)--
ENST00000502844RACK1-2031460-ENSP00000422029236 (aa)-D6R9Z1
ENST00000508682RACK1-2191208-ENSP00000424760147 (aa)-D6RAU2
ENST00000626067RACK1-235564-ENSP00000486170153 (aa)-E9PD14
ENST00000512968RACK1-2281058-ENSP00000425008321 (aa)-D6REE5
ENST00000502905RACK1-205643-ENSP00000426960198 (aa)-H0YAF8
ENST00000513027RACK1-229697-ENSP00000421356197 (aa)-D6RFZ9
ENST00000513060RACK1-2301651--- (aa)--
ENST00000511900RACK1-226922-ENSP00000422768269 (aa)-D6RAC2
ENST00000504128RACK1-209990-ENSP00000427677247 (aa)-H0YAM7
ENST00000503081RACK1-206587-ENSP00000424237160 (aa)-D6RBD0
ENST00000508044RACK1-218554--- (aa)--
ENST00000514183RACK1-2311439--- (aa)--
ENST00000505461RACK1-2121005--- (aa)--
ENST00000503494RACK1-208843-ENSP00000426111153 (aa)-E9PD14
ENST00000508963RACK1-220581--- (aa)--
ENST00000509535RACK1-222456-ENSP00000421838138 (aa)-H0Y8R5
ENST00000511566RACK1-225825-ENSP00000426101233 (aa)-D6RHH4
ENST00000514318RACK1-232581--- (aa)--
Gene Model
Click here to download ENSG00000204628's gene model file
Pathways
Pathway IDPathway NameSource
hsa05162MeaslesKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204628's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000204628RACK19778.723WBGene00010556rack-19872.188Caenorhabditis_elegans
ENSG00000204628RACK110079.487FBgn0020618Rack19979.812Drosophila_melanogaster
ENSG00000204628RACK1100100.000ENSMUSG00000020372Rack1100100.000Mus_musculus
ENSG00000204628RACK19766.667YMR116CASC19753.822Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001891phagocytic cup21347310.IDAComponent
GO:0001934positive regulation of protein phosphorylation21873635.IBAProcess
GO:0001934positive regulation of protein phosphorylation11312657.17108144.IDAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005080protein kinase C binding21873635.IBAFunction
GO:0005080protein kinase C binding11279199.IDAFunction
GO:0005102signaling receptor binding12809483.NASFunction
GO:0005515protein binding10849009.11046044.11279199.11312657.12809483.14500341.17108144.18194455.18420585.18816594.18954305.19674157.19785988.20010870.20080539.20103773.20541605.20871634.21098120.21146485.21347310.21525958.21750715.21988832.22210188.23866081.24947010.25910212.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus10849009.17108144.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm10849009.19785988.IDAComponent
GO:0005739mitochondrion19767770.IMPComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol19767770.IMPComponent
GO:0005829cytosol-TASComponent
GO:0006915apoptotic process-IEAProcess
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process19767770.IMPProcess
GO:0007049cell cycle-IEAProcess
GO:0007369gastrulation-IEAProcess
GO:0008200ion channel inhibitor activity-ISSFunction
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process19767770.IMPFunction
GO:0010629negative regulation of gene expression19451233.IMPProcess
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TASProcess
GO:0015935small ribosomal subunit-ISSComponent
GO:0016032viral process-IEAProcess
GO:0016567protein ubiquitination28132843.IMPProcess
GO:0017148negative regulation of translation-ISSProcess
GO:0019899enzyme binding21873635.IBAFunction
GO:0019899enzyme binding20819076.IPIFunction
GO:0019903protein phosphatase binding11278757.IPIFunction
GO:0022627cytosolic small ribosomal subunit21873635.IBAComponent
GO:0030178negative regulation of Wnt signaling pathway-ISSProcess
GO:0030292protein tyrosine kinase inhibitor activity9584165.IDAFunction
GO:0030308negative regulation of cell growth9584165.IDAProcess
GO:0030332cyclin binding15159402.IPIFunction
GO:0030335positive regulation of cell migration20499158.IDAProcess
GO:0030425dendrite-ISSComponent
GO:0030496midbody15166316.IDAComponent
GO:0030971receptor tyrosine kinase binding9584165.IDAFunction
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process19785988.IDAProcess
GO:0032464positive regulation of protein homooligomerization20541605.IDAProcess
GO:0032464positive regulation of protein homooligomerization19767770.IMPProcess
GO:0032880regulation of protein localization-ISSProcess
GO:0033137negative regulation of peptidyl-serine phosphorylation20103773.IMPProcess
GO:0035591signaling adaptor activity20103773.IMPFunction
GO:0042169SH2 domain binding9584165.11279199.IDAFunction
GO:0042803protein homodimerization activity24947010.IDAFunction
GO:0042998positive regulation of Golgi to plasma membrane protein transport19674157.IMPProcess
GO:0043022ribosome binding21873635.IBAFunction
GO:0043022ribosome binding28132843.IDAFunction
GO:0043025neuronal cell body-ISSComponent
GO:0043065positive regulation of apoptotic process20541605.IDAProcess
GO:0043065positive regulation of apoptotic process19767770.IMPProcess
GO:0043204perikaryon-IEAComponent
GO:0043473pigmentation-IEAProcess
GO:0043547positive regulation of GTPase activity20499158.IDAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0048471perinuclear region of cytoplasm11279199.IDAComponent
GO:0048511rhythmic process-IEAProcess
GO:0050765negative regulation of phagocytosis21347310.IMPProcess
GO:0051302regulation of cell division-ISSProcess
GO:0051343positive regulation of cyclic-nucleotide phosphodiesterase activity20819076.IMPProcess
GO:0051726regulation of cell cycle9584165.IDAProcess
GO:0051898negative regulation of protein kinase B signaling19767770.IMPProcess
GO:0051901positive regulation of mitochondrial depolarization19767770.IMPProcess
GO:0060090molecular adaptor activity20819076.TASFunction
GO:0061099negative regulation of protein tyrosine kinase activity-IEAProcess
GO:0070062extracellular exosome19056867.HDAComponent
GO:0071333cellular response to glucose stimulus20103773.IDAProcess
GO:0071363cellular response to growth factor stimulus20010870.IDAProcess
GO:0072344rescue of stalled ribosome21873635.IBAProcess
GO:0072344rescue of stalled ribosome28132843.IMPProcess
GO:1900102negative regulation of endoplasmic reticulum unfolded protein response22013210.TASProcess
GO:1903208negative regulation of hydrogen peroxide-induced neuron death24947010.IGIProcess
GO:1990630IRE1-RACK1-PP2A complex20103773.IDAComponent
GO:2000114regulation of establishment of cell polarity-ISSProcess
GO:2000304positive regulation of ceramide biosynthetic process-TASProcess
GO:2000543positive regulation of gastrulation-ISSProcess
GO:2001244positive regulation of intrinsic apoptotic signaling pathway19767770.IMPProcess
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