EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18055229	Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.	Immunity	2007 Dec	Pogge von Strandmann E	-
24133212	A soluble fragment of the tumor antigen BCL2-associated athanogene 6 (BAG-6) is essential and sufficient for inhibition of NKp30 receptor-dependent cytotoxicity of natural killer cells.	J Biol Chem	2013 Nov 29	Binici J	doi: 10.1074/jbc.M113.483602
25884493	Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.	PLoS One	2015 Apr 17	Etokebe GE	doi: 10.1371/journal.pone.0122651
24989925	BAT3 rs1052486 and rs3117582 polymorphisms are associated with lung cancer risk: a meta-analysis.	Tumour Biol	2014 Oct	Chen J	doi: 10.1007/s13277-014-1912-2
25430685	Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis.	Med Sci Monit	2014 Nov 28	Zhao J	doi: 10.12659/MSM.891141.
22641691	Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability.	J Cell Sci	2012 Sep 15	Wu W	doi: 10.1242/jcs.086553

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	31647688	Missense_Mutation	novel	E237Q	0.41
BLCA	chr6	31644540	Missense_Mutation	novel	H484Y	0.13
BLCA	chr6	31639121	3'UTR	novel		0.5
BLCA	chr6	31639602	Silent	novel	V1067V	0.05
BLCA	chr6	31651761	Translation_Start_Site	novel	M1?	0.37
BLCA	chr6	31639135	Frame_Shift_Del	novel	*P1132Lfs?**	0.36
BLCA	chr6	31649223	Silent	NA	V133V	0.39
BLCA	chr6	31640276	Nonsense_Mutation	novel	Q1027*	0.09
BRCA	chr6	31640409	Silent	NA	E1008E	0.46
BRCA	chr6	31642891	Missense_Mutation	novel	T631A	0.23
BRCA	chr6	31640224	Missense_Mutation	novel	S1044T	0.06
BRCA	chr6	31649204	Missense_Mutation	novel	L140F	0.12
BRCA	chr6	31644188	Missense_Mutation	NA	Q491R	0.26
BRCA	chr6	31641108	Missense_Mutation	novel	R898Q	0.5
BRCA	chr6	31639076	3'UTR	novel		0.16
BRCA	chr6	31641317	Splice_Region	novel		0.23
CESC	chr6	31647785	Silent	NA	P204P	0.12
CESC	chr6	31639223	Missense_Mutation	rs745856906	R1103W	0.25
CESC	chr6	31651669	Missense_Mutation	novel	I32S	0.37
CESC	chr6	31645454	Missense_Mutation	novel	H363D	0.13
CESC	chr6	31642225	Missense_Mutation	NA	S711F	0.27
CESC	chr6	31644557	Missense_Mutation	novel	P478L	0.37
CESC	chr6	31639705	Intron	NA		0.16
COAD	chr6	31641141	Missense_Mutation	NA	Q887R	0.48
COAD	chr6	31647623	Silent	NA	G258G	0.21
COAD	chr6	31644999	Missense_Mutation	rs773367157	R445Q	0.09
COAD	chr6	31651661	Frame_Shift_Del	NA	*A35Pfs3**	0.35
COAD	chr6	31640794	Frame_Shift_Del	NA	*Q948Sfs85**	0.33
COAD	chr6	31640232	Silent	NA	A1041A	0.14
COAD	chr6	31645193	Silent	novel	N380N	0.19
COAD	chr6	31645072	Missense_Mutation	NA	E421K	0.35
COAD	chr6	31645064	Silent	novel	S423S	0.16
COAD	chr6	31647673	Missense_Mutation	novel	R242C	0.19
COAD	chr6	31644125	Missense_Mutation	novel	A512D	0.29
COAD	chr6	31640686	Missense_Mutation	rs150422210	M955V	0.32
COAD	chr6	31640794	Frame_Shift_Del	NA	*Q948Sfs85**	0.37
ESCA	chr6	31644310	Intron	novel		0.21
ESCA	chr6	31647782	Silent	novel	Q205Q	0.34
ESCA	chr6	31649284	Missense_Mutation	novel	S113F	0.19
GBM	chr6	31648721	Nonsense_Mutation	novel	Q170*	0.15
GBM	chr6	31639586	Missense_Mutation	rs774730487	A1073T	0.22
GBM	chr6	31645483	Missense_Mutation	rs771400122	R353Q	0.33
GBM	chr6	31639105	3'UTR	novel		0.3
GBM	chr6	31640814	Missense_Mutation	novel	R941H	0.39
GBM	chr6	31639087	3'UTR	novel		0.43
HNSC	chr6	31645046	Silent	rs572580953	P429P	0.43
HNSC	chr6	31642976	Frame_Shift_Ins	novel	*M602Ifs3**	0.37
HNSC	chr6	31641578	Silent	novel	T810T	0.05
KIRC	chr6	31647628	Missense_Mutation	NA	A257T	0.41
KIRP	chr6	31644601	Missense_Mutation	NA	D463E	0.44
LGG	chr6	31645076	Missense_Mutation	NA	N419K	0.44
LGG	chr6	31644110	Missense_Mutation	novel	P517H	0.34
LIHC	chr6	31642295	Missense_Mutation	NA	P688S	0.07
LIHC	chr6	31640436	Silent	NA	E999E	0.17
LIHC	chr6	31639052	3'UTR	novel		0.23
LIHC	chr6	31642341	Missense_Mutation	NA	Q672H	0.16
LIHC	chr6	31640421	Silent	NA	S1004S	0.57
LIHC	chr6	31643106	Missense_Mutation	NA	T559I	0.42
LUAD	chr6	31643887	Splice_Region	novel		0.09
LUAD	chr6	31642295	Missense_Mutation	novel	P688A	0.19
LUAD	chr6	31640412	Silent	NA	T1007T	0.19
LUAD	chr6	31649266	Missense_Mutation	NA	G119V	0.88
LUAD	chr6	31641390	Silent	NA	I834I	0.21
LUAD	chr6	31644553	Silent	novel	L479L	0.09
LUAD	chr6	31645098	Missense_Mutation	NA	S412C	0.13
LUAD	chr6	31646460	Silent	NA	L290L	0.05
LUAD	chr6	31644986	Silent	NA	Q449Q	0.05
LUAD	chr6	31640226	Silent	novel	L1043L	0.24
LUSC	chr6	31642213	Missense_Mutation	novel	S715F	0.34
LUSC	chr6	31640426	Missense_Mutation	novel	A1003T	0.48
LUSC	chr6	31642213	Missense_Mutation	novel	S715F	0.37
LUSC	chr6	31647779	Silent	novel	P206P	0.17
LUSC	chr6	31649559	Silent	novel	L59L	0.1
LUSC	chr6	31640934	Missense_Mutation	rs747689534	R901L	0.2
LUSC	chr6	31641148	Missense_Mutation	NA	G885W	0.22
LUSC	chr6	31641322	Missense_Mutation	novel	T857I	0.2
LUSC	chr6	31639556	Missense_Mutation	NA	E1083K	0.11
LUSC	chr6	31647765	Missense_Mutation	rs770195862	P211L	0.27
LUSC	chr6	31647833	Silent	novel	Y188Y	0.08
LUSC	chr6	31641874	Missense_Mutation	NA	G773W	0.2
OV	chr6	31639509	Nonsense_Mutation	novel	Y1098*	0.03
OV	chr6	31644125	Missense_Mutation	novel	A512G	0.19
OV	chr6	31645434	Silent	novel	V369V	0.05
OV	chr6	31639076	3'UTR	novel		0.12
OV	chr6	31639076	3'UTR	novel		0.09
OV	chr6	31639581	Silent	rs749692025	A1074A	0.41
PAAD	chr6	31641835	Nonsense_Mutation	NA	R786*	0.17
PRAD	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.19
PRAD	chr6	31640403	Nonsense_Mutation	novel	W1010*	0.42
PRAD	chr6	31641140	Missense_Mutation	novel	Q887H	0.39
READ	chr6	31642255	Frame_Shift_Ins	novel	*F701Sfs24**	0.32
READ	chr6	31642163	Missense_Mutation	NA	R732C	0.38
READ	chr6	31642216	Missense_Mutation	novel	G714D	0.48
SARC	chr6	31645484	Nonsense_Mutation	NA	R353*	0.18
SARC	chr6	31639591	Missense_Mutation	novel	A1071D	0.16
SARC	chr6	31644094	Silent	novel	V522V	0.13
SARC	chr6	31646522	Missense_Mutation	novel	H270N	0.09
SKCM	chr6	31641835	Nonsense_Mutation	NA	R786*	0.07
SKCM	chr6	31649283	Silent	novel	S113S	0.33
SKCM	chr6	31640223	Silent	NA	S1044S	0.29
SKCM	chr6	31644974	Silent	rs767781873	P453P	0.2
SKCM	chr6	31644975	Missense_Mutation	NA	P453L	0.2
SKCM	chr6	31642315	Missense_Mutation	rs780725341	P681L	0.36
SKCM	chr6	31643901	Missense_Mutation	novel	P552L	0.68
SKCM	chr6	31641922	Missense_Mutation	rs747960997	L757F	0.18
SKCM	chr6	31644949	Nonsense_Mutation	novel	Q462*	0.1
SKCM	chr6	31640265	Silent	NA	R1030R	0.42
SKCM	chr6	31643952	Missense_Mutation	NA	A535D	0.16
SKCM	chr6	31640831	Silent	NA	A935A	0.3
SKCM	chr6	31644174	Missense_Mutation	NA	P496S	0.07
SKCM	chr6	31649279	Missense_Mutation	NA	P115S	0.06
SKCM	chr6	31643087	Silent	rs766003428	P565P	0.2
SKCM	chr6	31640507	Missense_Mutation	rs770643352	P976S	0.14
SKCM	chr6	31640508	Silent	novel	A975A	0.13
SKCM	chr6	31649326	Missense_Mutation	NA	S99Y	0.05
SKCM	chr6	31639204	Missense_Mutation	rs766837426	R1109Q	0.41
SKCM	chr6	31644975	Missense_Mutation	NA	P453L	0.23
SKCM	chr6	31641356	Missense_Mutation	novel	F846L	0.27
SKCM	chr6	31639544	Missense_Mutation	rs751639269	R1087W	0.59
SKCM	chr6	31639545	Silent	rs532488148	S1086S	0.59
SKCM	chr6	31642892	Silent	NA	P630P	0.24
SKCM	chr6	31645141	Missense_Mutation	rs755068976	P398S	0.24
SKCM	chr6	31649280	Silent	novel	P114P	0.25
SKCM	chr6	31646514	Silent	rs769519806	S272S	0.33
SKCM	chr6	31639091	3'UTR	rs762346541		0.51
SKCM	chr6	31642865	Silent	novel	V639V	0.25
SKCM	chr6	31651663	Missense_Mutation	novel	G34A	0.23
SKCM	chr6	31641924	Missense_Mutation	novel	S756F	0.36
STAD	chr6	31640406	Silent	NA	P1009P	0.08
STAD	chr6	31651661	Missense_Mutation	NA	A35T	0.47
STAD	chr6	31642154	Missense_Mutation	NA	G735R	0.06
STAD	chr6	31645445	Missense_Mutation	novel	T366A	0.14
STAD	chr6	31641570	Missense_Mutation	rs780710425	T813M	0.3
STAD	chr6	31639086	3'UTR	novel		0.21
STAD	chr6	31640794	Frame_Shift_Del	NA	*Q948Sfs85**	0.56
STAD	chr6	31640393	Missense_Mutation	novel	V1014F	0.13
STAD	chr6	31642253	Frame_Shift_Ins	novel	*T702Yfs23**	0.48
STAD	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.08
STAD	chr6	31646460	Silent	NA	L290L	0.58
STAD	chr6	31645112	Silent	NA	P407P	0.35
STAD	chr6	31641165	Missense_Mutation	NA	L879P	0.05
STAD	chr6	31647785	Silent	NA	P204P	0.04
STAD	chr6	31641205	Missense_Mutation	novel	L866V	0.05
STAD	chr6	31646491	Missense_Mutation	NA	L280P	0.25
STAD	chr6	31644103	Silent	NA	G519G	0.1
STAD	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.13
STAD	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.22
THYM	chr6	31641570	Missense_Mutation	rs780710425	T813M	0.15
UCEC	chr6	31639180	Missense_Mutation	novel	S1117I	0.44
UCEC	chr6	31641872	Silent	novel	G773G	0.28
UCEC	chr6	31642289	Missense_Mutation	novel	G690S	0.17
UCEC	chr6	31644121	Silent	NA	R513R	0.45
UCEC	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.3
UCEC	chr6	31640278	Missense_Mutation	novel	I1026T	0.05
UCEC	chr6	31639088	3'UTR	novel		0.27
UCEC	chr6	31647775	Missense_Mutation	novel	A208T	0.43
UCEC	chr6	31644159	Missense_Mutation	novel	R501W	0.47
UCEC	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.24
UCEC	chr6	31649229	Missense_Mutation	novel	S131R	0.36
UCEC	chr6	31641582	Missense_Mutation	novel	H809R	0.41
UCEC	chr6	31646464	Missense_Mutation	novel	R289H	0.45
UCEC	chr6	31640266	Missense_Mutation	rs767009688	R1030Q	0.35
UCEC	chr6	31639543	Missense_Mutation	NA	R1087Q	0.38
UCEC	chr6	31644103	Silent	novel	G519G	0.57
UCEC	chr6	31644978	Missense_Mutation	novel	E452V	0.47
UCEC	chr6	31640203	Missense_Mutation	novel	R1051H	0.23
UCEC	chr6	31644097	Frame_Shift_Ins	novel	*V522Sfs83**	0.38
UCEC	chr6	31645541	Missense_Mutation	novel	G334S	0.33
UCEC	chr6	31640528	Missense_Mutation	rs758960107	R969W	0.34
UCEC	chr6	31644314	Intron	rs754172219		0.4
UCEC	chr6	31645088	Silent	rs765304823	P415P	0.47
UCEC	chr6	31646477	Missense_Mutation	rs778920316	R285W	0.17
UCEC	chr6	31642878	Missense_Mutation	NA	A635V	0.27
UCEC	chr6	31642975	Missense_Mutation	novel	A603T	0.42
UCEC	chr6	31647806	Silent	rs752537003	P197P	0.42
UCEC	chr6	31644194	Missense_Mutation	novel	G489V	0.26
UCEC	chr6	31642878	Missense_Mutation	NA	A635V	0.21
UCEC	chr6	31646512	Missense_Mutation	novel	P273H	0.21
UCEC	chr6	31644313	Intron	NA		0.32
UCEC	chr6	31649277	Frame_Shift_Ins	rs761315497	*G116Wfs11**	0.53
UCEC	chr6	31640253	Silent	rs749994219	P1034P	0.33
UCEC	chr6	31649625	Missense_Mutation	NA	M37I	0.38
UCEC	chr6	31643911	Missense_Mutation	novel	L549I	0.47
UCEC	chr6	31644364	Intron	novel		0.28
UCEC	chr6	31642305	Silent	rs148186069	G684G	0.24
UCEC	chr6	31641144	Frame_Shift_Del	novel	*G886Dfs21**	0.56
UCEC	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.93
UCEC	chr6	31649278	Frame_Shift_Del	NA	*P115Lfs53**	0.46
UCEC	chr6	31642878	Missense_Mutation	NA	A635V	0.37
UCEC	chr6	31644364	Intron	novel		0.29
UCEC	chr6	31646502	Nonsense_Mutation	novel	Y276*	0.46
UCEC	chr6	31648918	Missense_Mutation	rs774339536	P157L	0.35
UCEC	chr6	31649556	Silent	novel	I60I	0.08
UCEC	chr6	31641108	Missense_Mutation	novel	R898Q	0.35
UCS	chr6	31639075	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0052	Kaplan-Meier Survival Analysis
KIRC	0.0061	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.005	Kaplan-Meier Survival Analysis
TGCT	0.032	Kaplan-Meier Survival Analysis
PAAD	0.046	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
LAML	0.0035	Kaplan-Meier Survival Analysis
UCEC	0.0055	Kaplan-Meier Survival Analysis
LIHC	0.0034	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000204463 (Gene tree)
Gene ID: 7917
Gene Symbol: BAG6
Alias: G3|D6S52E|BAT3
Full Name: BCL2 associated athanogene 6
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 21,740 bases
Position: chr6:31,639,028-31,660,767
Accession: 13919
Summary: This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18765639	BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.	Mol Cell Biol	2008 Nov	Nguyen P	doi: 10.1128/MCB.00568-08
29706626	Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC.	Cell Death Dis	2018 May 1	Ji J	doi: 10.1038/s41419-018-0528-7.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000424176	BAG6-239	747	-	ENSP00000391783	215 (aa)	-	F6XTU0
ENST00000438149	BAG6-246	714	-	ENSP00000410280	238 (aa)	-	H0Y759
ENST00000428326	BAG6-241	1051	-	ENSP00000413561	262 (aa)	-	F6U341
ENST00000362049	BAG6-235	3626	XM_017011291	ENSP00000354875	1077 (aa)	XP_016866780	P46379
ENST00000465348	BAG6-260	639	-	-	- (aa)	-	-
ENST00000462875	BAG6-257	972	-	-	- (aa)	-	-
ENST00000464126	BAG6-258	609	-	-	- (aa)	-	-
ENST00000441054	BAG6-248	654	-	ENSP00000406302	206 (aa)	-	F6U1F2
ENST00000456286	BAG6-254	807	-	ENSP00000406436	197 (aa)	-	F6UR09
ENST00000435080	BAG6-244	1710	-	ENSP00000411083	515 (aa)	-	F6S6P2
ENST00000464869	BAG6-259	488	-	-	- (aa)	-	-
ENST00000470875	BAG6-262	1000	-	-	- (aa)	-	-
ENST00000211379	BAG6-234	3779	XM_011514892	ENSP00000211379	1126 (aa)	XP_011513194	P46379
ENST00000422948	BAG6-238	513	-	ENSP00000413225	136 (aa)	-	H0Y4L1
ENST00000453833	BAG6-252	554	-	ENSP00000406434	185 (aa)	-	H0Y7K4
ENST00000469182	BAG6-261	653	-	-	- (aa)	-	-
ENST00000451898	BAG6-250	993	-	ENSP00000391613	243 (aa)	-	A0A1B0GX79
ENST00000434444	BAG6-243	766	-	ENSP00000394856	244 (aa)	-	F6WML8
ENST00000437771	BAG6-245	2407	-	ENSP00000397978	742 (aa)	-	X6REW1
ENST00000456622	BAG6-255	859	-	ENSP00000401031	244 (aa)	-	F6WML8
ENST00000462682	BAG6-256	349	-	-	- (aa)	-	-
ENST00000441793	BAG6-249	783	-	ENSP00000416633	226 (aa)	-	H0Y710
ENST00000454165	BAG6-253	544	-	ENSP00000396503	158 (aa)	-	F6TC96
ENST00000375976	BAG6-237	3644	XM_017011277	ENSP00000365143	1126 (aa)	XP_016866766	P46379
ENST00000452994	BAG6-251	880	-	ENSP00000404971	262 (aa)	-	F6U341
ENST00000424480	BAG6-240	1056	-	ENSP00000411043	258 (aa)	-	F6VEM6
ENST00000439687	BAG6-247	3104	-	ENSP00000402856	903 (aa)	-	P46379
ENST00000433828	BAG6-242	902	-	ENSP00000388244	259 (aa)	-	F6X9W3
ENST00000375964	BAG6-236	3815	-	ENSP00000365131	1132 (aa)	-	P46379

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000204463	Lupus Erythematosus, Systemic	1.24541E-9	18204098
ENSG00000204463	Lupus Erythematosus, Systemic	3.8264E-11	18204098
ENSG00000204463	Lupus Erythematosus, Systemic	3.3307E-16	18204098
ENSG00000204463	Breast Neoplasms	9.724E-20	17660530
ENSG00000204463	Diabetes Mellitus, Type 1	2.79E-119	19430480
ENSG00000204463	Diabetes Mellitus, Type 1	2.62E-83	19430480
ENSG00000204463	Diabetes Mellitus, Type 1	1.52E-71	19430480
ENSG00000204463	Diabetes Mellitus, Type 1	6.29E-135	19430480
ENSG00000204463	Lupus Erythematosus, Systemic	4.53E-8	18204446
ENSG00000204463	Platelet Function Tests	3.1500000E-006	-
ENSG00000204463	Platelet Function Tests	3.1500000E-006	-
ENSG00000204463	Blood Pressure	2E-11	21909115
ENSG00000204463	Adenocarcinoma of lung	5E-12	19836008
ENSG00000204463	Lung Neoplasms	4E-10	19654303
ENSG00000204463	Hypertension	1E-10	21909115
ENSG00000204463	Blood Pressure	3E-11	21909115
ENSG00000204463	Lung Neoplasms	5E-10	18978787
ENSG00000204463	Arthritis, Rheumatoid	3E-10	21844665

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204463	rs805303	6	31648589	A	Diastolic blood pressure	28739976	[0.13-0.33] unit decrease	0.23	EFO_0006336
ENSG00000204463	rs805303	6	31648589	A	Systolic blood pressure	28739976	[0.21-0.53] unit decrease	0.368	EFO_0006335
ENSG00000204463	rs115441327	6	31645962	C	Small cell lung carcinoma	28604730	[1.087902659-1.240674335]	1.1617801	EFO_0000702
ENSG00000204463	rs805303	6	31648589	A	Systolic blood pressure	27618447	unit decrease	0.0174	EFO_0006335
ENSG00000204463	rs1077393	6	31642752	A	Feeling worry	29500382	unit decrease	6.267	EFO_0009589
ENSG00000204463	rs805303	6	31648589	G	Diastolic blood pressure	21909115	[NR] mmHg increase	0.228	EFO_0006336
ENSG00000204463	rs805303	6	31648589	G	Hypertension	21909115	[NR] unit increase	0.054	EFO_0000537
ENSG00000204463	rs805303	6	31648589	G	Systolic blood pressure	21909115	[NR] mmHg increase	0.376	EFO_0006335
ENSG00000204463	rs1077393	6	31642752	A	Neurociticism	29500382	z score decrease	5.65	EFO_0007660
ENSG00000204463	rs115872194	6	31639897	?	Psoriatic arthritis	30552173	[NR] z-score increase	6.12	EFO_0003778

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204463's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204463	BAG6	99	97.778	ENSMUSG00000024392	Bag6	100	93.913	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001822	kidney development	-	ISS	Process
GO:0002429	immune response-activating cell surface receptor signaling pathway	18852879.	IDA	Process
GO:0005102	signaling receptor binding	18852879.	IPI	Function
GO:0005515	protein binding	14667819.14960581.16189514.17403783.18765639.18852879.21903422.22807449.23246001.25036637.25416956.25535373.25713138.26876100.29042515.	IPI	Function
GO:0005634	nucleus	14960581.17403783.21636303.29042515.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21636303.	IDA	Component
GO:0005829	cytosol	17403783.20676083.23246001.29042515.	IDA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	-	ISS	Process
GO:0006915	apoptotic process	14960581.	IDA	Process
GO:0007130	synaptonemal complex assembly	-	ISS	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0007420	brain development	-	ISS	Process
GO:0010498	proteasomal protein catabolic process	26565908.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	23246001.	IDA	Component
GO:0018393	internal peptidyl-lysine acetylation	17403783.	IDA	Process
GO:0030101	natural killer cell activation	18852879.	IDA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0030324	lung development	-	ISS	Process
GO:0030433	ubiquitin-dependent ERAD pathway	23129660.24981174.	IDA	Process
GO:0030433	ubiquitin-dependent ERAD pathway	26565908.	IMP	Process
GO:0030544	Hsp70 protein binding	-	IEA	Function
GO:0031593	polyubiquitin modification-dependent protein binding	-	ISS	Function
GO:0031625	ubiquitin protein ligase binding	21636303.24981174.	IPI	Function
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	-	ISS	Process
GO:0042127	regulation of cell proliferation	-	IEA	Process
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17403783.	IMP	Process
GO:0043022	ribosome binding	20676083.	IDA	Function
GO:0043066	negative regulation of apoptotic process	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045861	negative regulation of proteolysis	-	ISS	Process
GO:0045995	regulation of embryonic development	-	ISS	Process
GO:0050821	protein stabilization	-	ISS	Process
GO:0051787	misfolded protein binding	21636303.	IDA	Function
GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control	26565908.	IMP	Process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	ISS	Process
GO:0070062	extracellular exosome	18852879.	IDA	Component
GO:0070628	proteasome binding	-	ISS	Function
GO:0071712	ER-associated misfolded protein catabolic process	23129660.24981174.	IDA	Process
GO:0071816	tail-anchored membrane protein insertion into ER membrane	20676083.25535373.	IDA	Process
GO:0071818	BAT3 complex	20676083.21636303.25535373.	IDA	Component
GO:1904294	positive regulation of ERAD pathway	24424410.	IMP	Process
GO:1904378	maintenance of unfolded protein involved in ERAD pathway	21636303.	IMP	Process
GO:1904379	protein localization to cytosolic proteasome complex involved in ERAD pathway	21636303.	NAS	Process
GO:1990381	ubiquitin-specific protease binding	24424410.	IPI	Function

EuRBPDB

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Gene Ontology

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