EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18677113Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.Cell Cycle2008 AugPopowicz GM-
28460439Tumorigenesis promotes Mdm4-S overexpression.Oncotarget2017 Apr 18Pant Vdoi: 10.18632/oncotarget.15552.
22120712Abnormal MDMX degradation in tumor cells due to ARF deficiency.Oncogene2012 Aug 9Li Xdoi: 10.1038/onc.2011.534
19946469Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53.Aging (Albany NY)2009 JanHeminger K-
26867771The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.Tumour Biol2016 AugGansmo LBdoi: 10.1007/s13277-016-4940-2
21084273An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity.Cancer Res2010 Dec 1Wynendaele Jdoi: 10.1158/0008-5472.CAN-10-0527
14660608MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis.J Biol Chem2004 Feb 27Mancini F-
18356162Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.J Biol Chem2008 May 16Lopez-Pajares Vdoi: 10.1074/jbc.M710030200
17651783High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.Hum Pathol2007 OctValentin-Vega YA-
16027727Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Oncogene2005 Nov 24Steinman HA-
18172009Regulation of MDMX expression by mitogenic signaling.Mol Cell Biol2008 MarGilkes DMdoi: 10.1128/MCB.01633-07
22490292[Correlation of polymorphism rs1563828 in MDM4 gene with breast cancer risk and onset age].Zhonghua Wai Ke Za Zhi2012 Jan 1Song CG-
16616333A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.Cancer Cell2006 AprToledo F-
22333590Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.Cell Cycle2012 Mar 1Dolezelova Pdoi: 10.4161/cc.11.5.19445
28270148MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.Mol Cancer2017 Mar 7Mancini Fdoi: 10.1186/s12943-017-0626-7.
28351930Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate.Clin Cancer Res2017 Aug 1Kato Sdoi: 10.1158/1078-0432.CCR-16-3133
26471763MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.Cancer Med2015 DecGansmo LBdoi: 10.1002/cam4.555
26274820A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer.PLoS One2015 Aug 14Gao Fdoi: 10.1371/journal.pone.0135647
26181202Targeting Mdmx to treat breast cancers with wild-type p53.Cell Death Dis2015 Jul 16Haupt Sdoi: 10.1038/cddis.2015.173.
27738340A PRISMA-compliant meta-analysis of MDM4 genetic variants and cancer susceptibility.Oncotarget2016 Nov 8Zhai Ydoi: 10.18632/oncotarget.12558.
29697201Mir-1307 regulates cisplatin resistance by targeting Mdm4 in breast cancer expressing wild type P53.Thorac Cancer2018 JunWang Xdoi: 10.1111/1759-7714.12607
18279506Mutation analysis of the MDM4 gene in German breast cancer patients.BMC Cancer2008 Feb 15Reincke Sdoi: 10.1186/1471-2407-8-52.
25670033A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.Endocr Relat Cancer2015 AprStegeman Sdoi: 10.1530/ERC-15-0013
21750655A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.Neoplasia2011 JulWang H-
23793604Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility.Breast Cancer Res Treat2013 JulLiu Jdoi: 10.1007/s10549-013-2615-x
23994448Identification and expression of a novel MDM4 splice variant in human glioma.Brain Res2013 Nov 6Wang Xdoi: 10.1016/j.brainres.2013.07.054
26416355Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells.Oncotarget2015 Nov 3Slabakova Edoi: 10.18632/oncotarget.5392.
19762336A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.Carcinogenesis2009 NovKulkarni DAdoi: 10.1093/carcin/bgp224
20855462Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.Clin Cancer Res2010 Nov 1Sun Tdoi: 10.1158/1078-0432.CCR-10-1261
25026175Copy number analysis of 24 oncogenes: MDM4 identified as a putative marker for low recurrence risk in non muscle invasive bladder cancer.Int J Mol Sci2014 Jul 14Salvi Sdoi: 10.3390/ijms150712458.
27798881Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer.Anticancer Res2016 OctKriegmair MC-
21540763Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck.Pharmacogenet Genomics2011 JulYu Hdoi: 10.1097/FPC.0b013e32834632e4.
27646776The role of MDM4 SNP34091 A>C polymorphism in cancer: a meta-analysis on 19,328 patients and 51,058 controls.Int J Biol Markers2017 Mar 2Jin Xdoi: 10.5301/jbm.5000228.
27462918Variations within 3'-UTR of MDM4 gene contribute to clinical outcomes of advanced non-small cell lung cancer patients following platinum-based chemotherapy.Oncotarget2017 Mar 7Yang Ydoi: 10.18632/oncotarget.10771.
28097652MDM4 is a rational target for treating breast cancers with mutant p53.J Pathol2017 AprMiranda PJdoi: 10.1002/path.4877
28099948MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.Oncotarget2017 Mar 21Wang MYdoi: 10.18632/oncotarget.14666.
27742919The associations between MDM4 gene polymorphisms and cancer risk.Oncotarget2016 Aug 23Wang MJdoi: 10.18632/oncotarget.10877.
27687591MDM4 rs4245739 A > C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects.Oncotarget2016 Nov 1Xu Cdoi: 10.18632/oncotarget.12326.
28164646Analysis of the Association between MDM4 rs4245739 Single Nucleotide Polymorphism and Breast Cancer Susceptibility.Clin Lab2016 Jul 1Pedram Ndoi: 10.7754/Clin.Lab.2016.151128.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1204542866SilentNAL198L0.35
BLCAchr1204525522Missense_MutationnovelT2S0.26
BLCAchr1204538206Splice_Regionnovel0.18
BLCAchr1204532197SilentNAL98L0.29
BRCAchr1204537480Missense_MutationNAS132C0.1
BRCAchr1204526424Frame_Shift_DelNAT48Sfs*20.16
BRCAchr1204544642SilentNAT260T0.2
BRCAchr1204538218Missense_MutationNAE141K0.36
CHOLchr1204532784Intronnovel0.62
COADchr1204549672In_Frame_InsnovelF488_I489insC0.07
COADchr1204549320Missense_MutationNAV371I0.41
COADchr1204542943Missense_MutationNAQ224L0.31
COADchr1204542848SilentNAE192E0.39
COADchr1204546825Missense_MutationNAL284P0.19
COADchr1204538264Missense_MutationNAP156H0.07
COADchr1204542879Missense_MutationNAL203I0.1
COADchr12045496923'UTRrs7557386450.41
COADchr1204544651Frame_Shift_InsnovelS264*0.04
GBMchr1204525572Missense_MutationnovelR18S0.4
GBMchr1204538276Missense_MutationNAT160S0.39
GBMchr1204549506Missense_MutationnovelL433I0.23
HNSCchr1204549314Missense_Mutationrs140091735P369S0.37
KIRPchr12045498643'UTRnovel0.4
LGGchr1204549221Missense_MutationNAT338P0.13
LUADchr1204537937Intronnovel0.06
LUADchr1204544567SilentnovelT235T0.17
LUADchr1204549160Missense_MutationnovelK317N0.27zf-RanBP
LUADchr12045496993'UTRnovel0.08
LUADchr12045497013'UTRnovel0.09
LUADchr1204526414Missense_MutationnovelE45K0.09
LUADchr1204537458Missense_MutationnovelQ124H0.18
LUADchr1204542883Missense_MutationNAG204V0.19
LUSCchr1204544636SilentnovelA258A0.24
LUSCchr1204549134Missense_MutationnovelC309S0.15zf-RanBP
LUSCchr1204549118Missense_MutationnovelE303D0.12zf-RanBP
OVchr1204544585Missense_MutationNAL241F0.2
OVchr1204549126Missense_MutationnovelC306S0.03zf-RanBP
OVchr1204549174Missense_MutationnovelR322P0.08zf-RanBP
OVchr1204546829SilentNAE285E0.15
OVchr1204549183Missense_MutationnovelA325V0.05zf-RanBP
OVchr12045498283'UTRnovel0.17
PRADchr1204532807Intronnovel0.41
PRADchr1204544648Missense_MutationNAQ262H0.31
READchr12045496923'UTRrs7557386450.29
READchr1204549309Missense_Mutationrs201947927S367L0.48
READchr1204549132Missense_MutationNAE308A0.11zf-RanBP
SKCMchr1204532201Missense_MutationNAD100N0.21
SKCMchr12045497193'UTRnovel0.42
SKCMchr1204544632Missense_MutationNAA257V0.42
SKCMchr1204538263Missense_MutationnovelP156S0.39
SKCMchr1204542864SilentNAL198L0.41
STADchr1204532776Intronnovel0.22
STADchr1204542834Missense_MutationNAL188F0.14
STADchr1204537493Missense_MutationnovelL136P0.25
STADchr1204549320Missense_MutationNAV371I0.26
STADchr1204542939Missense_MutationNAN223D0.48
STADchr12045496923'UTRrs7557386450.29
STADchr1204530706Missense_MutationnovelY59C0.08
STADchr1204537489Missense_MutationNAQ135K0.23
THCAchr12045497843'UTRnovel0.33
UCECchr1204538257Missense_MutationNAD154N0.37
UCECchr1204530750Missense_MutationNAV74I0.18
UCECchr1204537991IntronNA0.44
UCECchr1204549238Silentrs770826577T343T0.17
UCECchr1204549387Missense_MutationNAE393G0.27
UCECchr12045255045'UTRNA0.3
UCECchr1204546856Silentrs773085031T294T0.36
UCECchr1204537453Missense_Mutationrs145156544A123T0.22
UCECchr1204537921Intronnovel0.27
UCECchr12045496913'UTRrs5404369430.65
UCECchr1204544554Missense_MutationnovelV231A0.09
UCECchr1204549352Missense_MutationnovelE381D0.21
UCECchr1204538256Silentrs775928214D153D0.16
UCECchr1204549640SilentNAC477C0.2
UCECchr1204544641Missense_MutationnovelT260I0.38
UCECchr1204549681Silentnovel*491*0.3
UCECchr1204549557Frame_Shift_InsnovelI450Tfs*380.08
UCECchr1204549495In_Frame_InsnovelD429delinsESLWKV0.13
UCECchr1204549424Missense_MutationnovelE405D0.27
UCECchr1204538305Missense_MutationnovelE170K0.15
UCECchr1204549237Missense_MutationnovelT343M0.05
UCECchr1204538257Missense_MutationNAD154N0.3
UCECchr1204526372SilentnovelL31L0.09
UCECchr1204542809SilentNAA179A0.13
UCECchr1204549571Silentrs775939262T454T0.17
UCECchr1204530740SilentnovelE70E0.36
UCECchr1204549190SilentnovelR327R0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.09070.033566
DLBCDEL0.04170.0017831
GBMAMP0.23922.2156e-76
KIRCAMP0.0890.059566
LGGAMP0.0761.9242e-17
READAMP0.27880.14328
TGCTAMP0.35330.088103
THCAAMP0.04810.075436

Survival Analysis
CancerP-value Q-value
THYM0.0014

Kaplan-Meier Survival Analysis

KIRC0.0013

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

HNSC0.0062

Kaplan-Meier Survival Analysis

SKCM0.0063

Kaplan-Meier Survival Analysis

PRAD0.0035

Kaplan-Meier Survival Analysis

COAD0.022

Kaplan-Meier Survival Analysis

PAAD0.031

Kaplan-Meier Survival Analysis

BLCA0.0006

Kaplan-Meier Survival Analysis

LAML0.00012

Kaplan-Meier Survival Analysis

GBM0.0083

Kaplan-Meier Survival Analysis

LGG0.0032

Kaplan-Meier Survival Analysis

LUAD0.017

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000198625 (Gene tree)
Gene ID
4194
Gene Symbol
MDM4
Alias
MDMX|HDMX
Full Name
MDM4 regulator of p53
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
65,303 bases
Position
chr1:204,516,379-204,581,681
Accession
6974
RBP type
canonical RBP
Summary
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000395254zf-RanBPPF00641.186.9e-0911
ENSP00000478080zf-RanBPPF00641.182.3e-0811
ENSP00000356147zf-RanBPPF00641.183.6e-0811
ENSP00000482388zf-RanBPPF00641.183.9e-0811
ENSP00000396840zf-RanBPPF00641.184.5e-0811
ENSP00000356150zf-RanBPPF00641.185.1e-0811

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28837642Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.PLoS One2017 Aug 24Kulp JL 3rddoi: 10.1371/journal.pone.0183327
26867771The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.Tumour Biol2016 AugGansmo LBdoi: 10.1007/s13277-016-4940-2
26876197Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.Oncogene2016 Sep 8Xie Xdoi: 10.1038/onc.2016.12
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000367182MDM4-20310073XM_017001311ENSP00000356150490 (aa)XP_016856800O15151
ENST00000463049MDM4-2096102--- (aa)--
ENST00000616250MDM4-2169597-ENSP00000478581116 (aa)-A0A087WUE3
ENST00000614459MDM4-2159782-ENSP00000482388392 (aa)-A0A087WZ58
ENST00000444261MDM4-206513-ENSP00000395254171 (aa)-Q5T0Y3
ENST00000507825MDM4-213481-ENSP00000443816140 (aa)-Q68DC0
ENST00000391947MDM4-20510008-ENSP00000375811140 (aa)-Q68DC0
ENST00000471783MDM4-212552--- (aa)--
ENST00000462012MDM4-208582--- (aa)--
ENST00000470908MDM4-211884--- (aa)--
ENST00000367180MDM4-202547-ENSP00000356148131 (aa)-Q5T0Y4
ENST00000454264MDM4-2079926XM_017001313ENSP00000396840440 (aa)XP_016856802O15151
ENST00000367183MDM4-2049098-ENSP00000356151164 (aa)-O15151
ENST00000612738MDM4-2149407-ENSP00000478080267 (aa)-A0A087WTR9
ENST00000367179MDM4-201697-ENSP00000356147213 (aa)-Q5T0Y2
ENST00000470797MDM4-210909--- (aa)--
ENST00000621032MDM4-2175592-ENSP00000482479153 (aa)-Q6MZR7
Gene Model
Click here to download ENSG00000198625's gene model file
Pathways
Pathway IDPathway NameSource
hsa04115p53 signaling pathwayKEGG
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000198625Neuropsychological Tests5E-619734545
ENSG00000198625Breast Neoplasms8E-1827117709
ENSG00000198625Breast Neoplasms1E-723544013
ENSG00000198625Education3E-927225129
ENSG00000198625Triple Negative Breast Neoplasms4E-624325915
ENSG00000198625Prostatic Neoplasms2E-1123535732
ENSG00000198625Breast Neoplasms2E-1223535733
ENSG00000198625Breast Neoplasms6E-1527117709
ENSG00000198625Education5E-825201988
ENSG00000198625Education3E-1327225129
ENSG00000198625Education8E-1223722424
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000198625rs42457391204549714CBreast cancer (estrogen-receptor negative)29058716[1.11-1.16]1.14EFO_1000650
ENSG00000198625rs42457391204549714ASystolic blood pressure27618452[0.19-0.46] mm Hg increase0.326EFO_0006335
ENSG00000198625rs42457391204549714ADiastolic blood pressure27618452[0.16-0.32] mm Hg increase0.243EFO_0006336
ENSG00000198625rs42457391204549714?Breast cancer27117709[1.05-1.14] (BRCA1 carriers)1.09EFO_0000305
ENSG00000198625rs42457391204549714?Breast cancer (estrogen-receptor negative)27117709[1.11-1.19]1.13EFO_1000650
ENSG00000198625rs42457391204549714?Breast cancer23535733[1.10-1.18]1.14EFO_0000305
ENSG00000198625rs42457391204549714AProstate cancer23535732[1.05-1.14]1.1EFO_0001663
ENSG00000198625rs22908541204546897ABreast Cancer in BRCA1 mutation carriers23544013[1.08-1.18]1.13EFO_0000305
ENSG00000198625rs42457391204549714?Diastolic blood pressure (cigarette smoking interaction)29455858EFO_0006527|EFO_0006336
ENSG00000198625rs42527071204539019ANon-glioblastoma glioma283464431.12-1.261.19EFO_0000326|EFO_0005543
ENSG00000198625rs10468741204557932?Lung function (FVC)30595370EFO_0004312
ENSG00000198625rs42457391204549714AProstate cancer29892016[1.08-1.12]1.1EFO_0001663
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198625's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000198625MDM49350.000ENSAMEG00000008526MDM29332.213Ailuropoda_melanoleuca
ENSG00000198625MDM410094.545ENSAMEG00000001126MDM410092.886Ailuropoda_melanoleuca
ENSG00000198625MDM49234.328ENSAPLG00000011164MDM29734.476Anas_platyrhynchos
ENSG00000198625MDM49767.257ENSACAG00000007350-10057.637Anolis_carolinensis
ENSG00000198625MDM46159.155ENSACAG00000004204MDM28133.124Anolis_carolinensis
ENSG00000198625MDM49031.174ENSANAG00000027171-7958.025Aotus_nancymaae
ENSG00000198625MDM410097.004ENSANAG00000036891MDM410097.004Aotus_nancymaae
ENSG00000198625MDM410093.077ENSANAG00000025757-10083.673Aotus_nancymaae
ENSG00000198625MDM49450.459ENSBTAG00000010422MDM29432.460Bos_taurus
ENSG00000198625MDM410091.324ENSBTAG00000006255MDM410089.817Bos_taurus
ENSG00000198625MDM410088.462ENSBTAG00000054094-10090.698Bos_taurus
ENSG00000198625MDM49131.042ENSCJAG00000042596-9232.573Callithrix_jacchus
ENSG00000198625MDM46954.930ENSCJAG00000007464-6158.025Callithrix_jacchus
ENSG00000198625MDM410096.403ENSCJAG00000016986MDM410096.330Callithrix_jacchus
ENSG00000198625MDM410094.091ENSCAFG00000009669MDM410093.496Canis_familiaris
ENSG00000198625MDM49350.000ENSCAFG00000000418MDM28832.298Canis_familiaris
ENSG00000198625MDM49350.000ENSCAFG00020017002MDM29431.992Canis_lupus_dingo
ENSG00000198625MDM49882.099ENSCAFG00020005984MDM49992.962Canis_lupus_dingo
ENSG00000198625MDM49946.957ENSCHIG00000019939-9431.992Capra_hircus
ENSG00000198625MDM48884.574ENSCHIG00000027135-10072.379Capra_hircus
ENSG00000198625MDM410090.428ENSCHIG00000010343-10090.428Capra_hircus
ENSG00000198625MDM410096.154ENSTSYG00000010731MDM410096.154Carlito_syrichta
ENSG00000198625MDM46960.606ENSTSYG00000031248-8560.870Carlito_syrichta
ENSG00000198625MDM49092.593ENSCAPG00000011380MDM49683.047Cavia_aperea
ENSG00000198625MDM49589.247ENSCPOG00000008227MDM49689.247Cavia_porcellus
ENSG00000198625MDM49349.074ENSCPOG00000004323MDM29431.493Cavia_porcellus
ENSG00000198625MDM47054.930ENSCCAG00000006745-6958.025Cebus_capucinus
ENSG00000198625MDM49898.246ENSCCAG00000031000MDM410096.226Cebus_capucinus
ENSG00000198625MDM410096.154ENSCCAG00000035274-10096.154Cebus_capucinus
ENSG00000198625MDM48434.722ENSCATG00000000265-8234.359Cercocebus_atys
ENSG00000198625MDM4100100.000ENSCATG00000027086MDM4100100.000Cercocebus_atys
ENSG00000198625MDM46760.345ENSCATG00000045264-8061.429Cercocebus_atys
ENSG00000198625MDM49892.982ENSCLAG00000011995MDM410088.798Chinchilla_lanigera
ENSG00000198625MDM49947.826ENSCLAG00000009877MDM29731.021Chinchilla_lanigera
ENSG00000198625MDM4100100.000ENSCSAG00000014561MDM410097.959Chlorocebus_sabaeus
ENSG00000198625MDM49231.712ENSCSAG00000004244MDM29432.510Chlorocebus_sabaeus
ENSG00000198625MDM47295.181ENSCHOG00000013096-10088.166Choloepus_hoffmanni
ENSG00000198625MDM49878.261ENSCHOG00000008147-7895.122Choloepus_hoffmanni
ENSG00000198625MDM49232.017ENSCPBG00000013316MDM29733.265Chrysemys_picta_bellii
ENSG00000198625MDM46760.345ENSCANG00000034475MDM28061.429Colobus_angolensis_palliatus
ENSG00000198625MDM48697.024ENSCANG00000032288MDM49997.024Colobus_angolensis_palliatus
ENSG00000198625MDM49847.368ENSCGRG00001022261Mdm29931.335Cricetulus_griseus_chok1gshd
ENSG00000198625MDM410084.018ENSCGRG00001004339Mdm410083.537Cricetulus_griseus_chok1gshd
ENSG00000198625MDM410084.018ENSCGRG00000008463Mdm410083.537Cricetulus_griseus_crigri
ENSG00000198625MDM49946.957ENSCGRG00000017891Mdm29931.034Cricetulus_griseus_crigri
ENSG00000198625MDM49947.826ENSDNOG00000046929-9033.333Dasypus_novemcinctus
ENSG00000198625MDM410092.308ENSDNOG00000000842MDM410089.431Dasypus_novemcinctus
ENSG00000198625MDM48535.915ENSDORG00000007222Mdm29934.074Dipodomys_ordii
ENSG00000198625MDM49984.663ENSDORG00000006873Mdm49984.663Dipodomys_ordii
ENSG00000198625MDM410087.671ENSETEG00000011245MDM410080.081Echinops_telfairi
ENSG00000198625MDM48552.381ENSETEG00000011183MDM27651.376Echinops_telfairi
ENSG00000198625MDM49230.753ENSEASG00005008055-9432.150Equus_asinus_asinus
ENSG00000198625MDM410096.347ENSEASG00005011431MDM410094.705Equus_asinus_asinus
ENSG00000198625MDM49232.017ENSECAG00000013604MDM29432.848Equus_caballus
ENSG00000198625MDM410096.347ENSECAG00000004843MDM410094.705Equus_caballus
ENSG00000198625MDM410082.028ENSEEUG00000013912MDM410065.041Erinaceus_europaeus
ENSG00000198625MDM48050.538ENSEEUG00000013849MDM25358.824Erinaceus_europaeus
ENSG00000198625MDM49060.952ENSELUG00000011889mdm410045.873Esox_lucius
ENSG00000198625MDM49250.467ENSFCAG00000024456MDM29731.273Felis_catus
ENSG00000198625MDM410094.977ENSFCAG00000014851MDM410094.977Felis_catus
ENSG00000198625MDM48843.750ENSFDAG00000007913-9731.898Fukomys_damarensis
ENSG00000198625MDM410086.992ENSFDAG00000021356MDM410086.992Fukomys_damarensis
ENSG00000198625MDM49755.752ENSGMOG00000016389mdm49943.701Gadus_morhua
ENSG00000198625MDM49234.615ENSGALG00000009942MDM29931.434Gallus_gallus
ENSG00000198625MDM46157.746ENSGAGG00000017565-7034.677Gopherus_agassizii
ENSG00000198625MDM4100100.000ENSGGOG00000012957MDM4100100.000Gorilla_gorilla
ENSG00000198625MDM47054.930ENSGGOG00000012907MDM27158.025Gorilla_gorilla
ENSG00000198625MDM48431.690ENSHGLG00000016066-9931.081Heterocephalus_glaber_female
ENSG00000198625MDM410089.206ENSHGLG00000007642MDM410089.206Heterocephalus_glaber_female
ENSG00000198625MDM49230.228ENSHGLG00000020526-9232.252Heterocephalus_glaber_female
ENSG00000198625MDM49847.368ENSHGLG00000000856-9432.460Heterocephalus_glaber_female
ENSG00000198625MDM47749.074ENSHGLG00100000441-9232.394Heterocephalus_glaber_male
ENSG00000198625MDM410088.821ENSHGLG00100006704-10088.821Heterocephalus_glaber_male
ENSG00000198625MDM49258.974ENSHCOG00000008924mdm49944.444Hippocampus_comes
ENSG00000198625MDM49462.385ENSIPUG00000024447mdm410046.479Ictalurus_punctatus
ENSG00000198625MDM49948.696ENSSTOG00000014702-9432.025Ictidomys_tridecemlineatus
ENSG00000198625MDM49987.671ENSSTOG00000024007-10079.226Ictidomys_tridecemlineatus
ENSG00000198625MDM410091.039ENSSTOG00000004184MDM410091.039Ictidomys_tridecemlineatus
ENSG00000198625MDM49890.351ENSJJAG00000017144Mdm410083.707Jaculus_jaculus
ENSG00000198625MDM49233.680ENSLACG00000010207MDM29434.809Latimeria_chalumnae
ENSG00000198625MDM49151.351ENSLAFG00000005885MDM29433.333Loxodonta_africana
ENSG00000198625MDM410089.954ENSLAFG00000002169MDM410087.169Loxodonta_africana
ENSG00000198625MDM46760.345ENSMFAG00000042359MDM28061.429Macaca_fascicularis
ENSG00000198625MDM4100100.000ENSMFAG00000033606MDM4100100.000Macaca_fascicularis
ENSG00000198625MDM4100100.000ENSMMUG00000011236MDM4100100.000Macaca_mulatta
ENSG00000198625MDM47054.930ENSMMUG00000014193MDM29433.255Macaca_mulatta
ENSG00000198625MDM4100100.000ENSMNEG00000026547MDM4100100.000Macaca_nemestrina
ENSG00000198625MDM46760.345ENSMNEG00000041135MDM28061.429Macaca_nemestrina
ENSG00000198625MDM4100100.000ENSMLEG00000032041MDM4100100.000Mandrillus_leucophaeus
ENSG00000198625MDM46760.345ENSMLEG00000042099MDM28061.429Mandrillus_leucophaeus
ENSG00000198625MDM410030.222ENSMGAG00000010513MDM29936.111Meleagris_gallopavo
ENSG00000198625MDM49873.292ENSMAUG00000009703-9085.514Mesocricetus_auratus
ENSG00000198625MDM49873.292ENSMAUG00000017821-9285.514Mesocricetus_auratus
ENSG00000198625MDM49897.368ENSMICG00000017021MDM410092.464Microcebus_murinus
ENSG00000198625MDM49946.087ENSMICG00000029037-9031.155Microcebus_murinus
ENSG00000198625MDM49448.624ENSMOCG00000008043Mdm29431.458Microtus_ochrogaster
ENSG00000198625MDM410086.239ENSMOCG00000002099Mdm410085.336Microtus_ochrogaster
ENSG00000198625MDM48989.320ENSMODG00000001605MDM410076.056Monodelphis_domestica
ENSG00000198625MDM49234.672ENSMODG00000007219-9434.979Monodelphis_domestica
ENSG00000198625MDM49164.865ENSMALG00000020663mdm49946.535Monopterus_albus
ENSG00000198625MDM49887.719MGP_CAROLIEiJ_G0014593Mdm410083.910Mus_caroli
ENSG00000198625MDM48139.516MGP_CAROLIEiJ_G0015836Mdm29930.268Mus_caroli
ENSG00000198625MDM49887.719ENSMUSG00000054387Mdm410083.910Mus_musculus
ENSG00000198625MDM47846.789ENSMUSG00000020184Mdm29931.499Mus_musculus
ENSG00000198625MDM47846.789MGP_PahariEiJ_G0031251Mdm29931.335Mus_pahari
ENSG00000198625MDM49885.965MGP_PahariEiJ_G0027829Mdm410082.857Mus_pahari
ENSG00000198625MDM48346.789MGP_SPRETEiJ_G0016659Mdm29931.731Mus_spretus
ENSG00000198625MDM49887.719MGP_SPRETEiJ_G0015400Mdm410083.707Mus_spretus
ENSG00000198625MDM49848.246ENSMPUG00000017505MDM29432.520Mustela_putorius_furo
ENSG00000198625MDM410091.855ENSMPUG00000011721MDM410091.075Mustela_putorius_furo
ENSG00000198625MDM410085.388ENSMLUG00000007129MDM410081.301Myotis_lucifugus
ENSG00000198625MDM49950.435ENSMLUG00000009997MDM29832.490Myotis_lucifugus
ENSG00000198625MDM410088.391ENSNGAG00000012344Mdm410088.391Nannospalax_galili
ENSG00000198625MDM49946.957ENSNGAG00000012154Mdm29433.888Nannospalax_galili
ENSG00000198625MDM4100100.000ENSNLEG00000014271MDM4100100.000Nomascus_leucogenys
ENSG00000198625MDM47054.930ENSNLEG00000003757MDM29433.647Nomascus_leucogenys
ENSG00000198625MDM49389.815ENSMEUG00000012624-8576.744Notamacropus_eugenii
ENSG00000198625MDM49590.108ENSOPRG00000013878MDM410090.108Ochotona_princeps
ENSG00000198625MDM49946.957ENSOPRG00000009677MDM29831.369Ochotona_princeps
ENSG00000198625MDM49230.687ENSODEG00000000416-8353.750Octodon_degus
ENSG00000198625MDM410089.409ENSODEG00000013499MDM410089.409Octodon_degus
ENSG00000198625MDM49945.385ENSODEG00000004028-9933.465Octodon_degus
ENSG00000198625MDM49845.614ENSODEG00000006648-5651.765Octodon_degus
ENSG00000198625MDM49831.172ENSOANG00000005942MDM210034.130Ornithorhynchus_anatinus
ENSG00000198625MDM49088.889ENSOANG00000013464MDM410072.650Ornithorhynchus_anatinus
ENSG00000198625MDM410090.868ENSOCUG00000000005MDM410089.817Oryctolagus_cuniculus
ENSG00000198625MDM49242.537ENSOCUG00000010899-6032.465Oryctolagus_cuniculus
ENSG00000198625MDM49947.826ENSOCUG00000011354-9433.058Oryctolagus_cuniculus
ENSG00000198625MDM49231.866ENSOGAG00000034779MDM29532.924Otolemur_garnettii
ENSG00000198625MDM46554.930ENSOGAG00000011845-9532.665Otolemur_garnettii
ENSG00000198625MDM49892.982ENSOGAG00000011679MDM410089.091Otolemur_garnettii
ENSG00000198625MDM48348.624ENSOARG00000013821-9431.864Ovis_aries
ENSG00000198625MDM410090.020ENSOARG00000002783-10090.020Ovis_aries
ENSG00000198625MDM48348.624ENSOARG00000000570-9331.537Ovis_aries
ENSG00000198625MDM4100100.000ENSPPAG00000030518MDM4100100.000Pan_paniscus
ENSG00000198625MDM47054.930ENSPPAG00000032775MDM27158.025Pan_paniscus
ENSG00000198625MDM49250.467ENSPPRG00000000082MDM29731.385Panthera_pardus
ENSG00000198625MDM410094.977ENSPPRG00000025076MDM410094.977Panthera_pardus
ENSG00000198625MDM49250.467ENSPTIG00000016929MDM29731.273Panthera_tigris_altaica
ENSG00000198625MDM410094.570ENSPTIG00000011372MDM410090.650Panthera_tigris_altaica
ENSG00000198625MDM4100100.000ENSPTRG00000001889MDM4100100.000Pan_troglodytes
ENSG00000198625MDM47054.930ENSPTRG00000005203MDM27158.025Pan_troglodytes
ENSG00000198625MDM4100100.000ENSPANG00000008555MDM4100100.000Papio_anubis
ENSG00000198625MDM46760.345ENSPANG00000005563MDM28061.429Papio_anubis
ENSG00000198625MDM49232.059ENSPSIG00000016379-10033.264Pelodiscus_sinensis
ENSG00000198625MDM410087.215ENSPEMG00000018483Mdm410085.569Peromyscus_maniculatus_bairdii
ENSG00000198625MDM49787.611ENSPCIG00000017446MDM410074.291Phascolarctos_cinereus
ENSG00000198625MDM49234.038ENSPCIG00000005357-6961.728Phascolarctos_cinereus
ENSG00000198625MDM49232.189ENSPPYG00000004754MDM29332.724Pongo_abelii
ENSG00000198625MDM410098.980ENSPPYG00000000315MDM410098.980Pongo_abelii
ENSG00000198625MDM410084.932ENSPCAG00000007019MDM410078.455Procavia_capensis
ENSG00000198625MDM49350.459ENSPCAG00000008949MDM29333.747Procavia_capensis
ENSG00000198625MDM49898.246ENSPCOG00000024397MDM410096.154Propithecus_coquereli
ENSG00000198625MDM48931.808ENSPCOG00000018521-8858.929Propithecus_coquereli
ENSG00000198625MDM49945.217ENSPVAG00000006202MDM29830.829Pteropus_vampyrus
ENSG00000198625MDM410088.584ENSPVAG00000005663MDM410082.281Pteropus_vampyrus
ENSG00000198625MDM49230.983ENSRNOG00000006304Mdm29431.875Rattus_norvegicus
ENSG00000198625MDM410084.932ENSRNOG00000009696Mdm410083.943Rattus_norvegicus
ENSG00000198625MDM4100100.000ENSRBIG00000038824MDM4100100.000Rhinopithecus_bieti
ENSG00000198625MDM47054.930ENSRBIG00000028561MDM29433.255Rhinopithecus_bieti
ENSG00000198625MDM4100100.000ENSRROG00000027771MDM4100100.000Rhinopithecus_roxellana
ENSG00000198625MDM46859.016ENSRROG00000045589-8160.274Rhinopithecus_roxellana
ENSG00000198625MDM49996.154ENSSBOG00000020446-9996.154Saimiri_boliviensis_boliviensis
ENSG00000198625MDM46660.377ENSSBOG00000014544-7662.000Saimiri_boliviensis_boliviensis
ENSG00000198625MDM410097.753ENSSBOG00000036183-10097.753Saimiri_boliviensis_boliviensis
ENSG00000198625MDM49786.726ENSSHAG00000007767MDM410076.016Sarcophilus_harrisii
ENSG00000198625MDM49233.612ENSSHAG00000010284-9434.350Sarcophilus_harrisii
ENSG00000198625MDM46061.429ENSSHAG00000000124-9232.412Sarcophilus_harrisii
ENSG00000198625MDM49661.261ENSSFOG00015001112mdm410048.509Scleropages_formosus
ENSG00000198625MDM47953.261ENSSARG00000005801MDM29831.287Sorex_araneus
ENSG00000198625MDM410085.654ENSSARG00000004179MDM410082.688Sorex_araneus
ENSG00000198625MDM49447.706ENSSPUG00000000964MDM29534.012Sphenodon_punctatus
ENSG00000198625MDM49897.368ENSSSCG00000015284MDM49993.075Sus_scrofa
ENSG00000198625MDM49946.957ENSSSCG00000000488MDM29930.705Sus_scrofa
ENSG00000198625MDM410051.364ENSTGUG00000017483MDM410057.632Taeniopygia_guttata
ENSG00000198625MDM49432.405ENSTGUG00000006836MDM29934.783Taeniopygia_guttata
ENSG00000198625MDM48986.772ENSTBEG00000011684MDM47686.039Tupaia_belangeri
ENSG00000198625MDM48235.252ENSTBEG00000013758MDM25331.873Tupaia_belangeri
ENSG00000198625MDM47646.809ENSTTRG00000015715MDM27846.809Tursiops_truncatus
ENSG00000198625MDM410092.806ENSTTRG00000012174MDM410089.817Tursiops_truncatus
ENSG00000198625MDM410094.091ENSUAMG00000007328MDM410092.683Ursus_americanus
ENSG00000198625MDM49350.000ENSUAMG00000018322-9832.096Ursus_americanus
ENSG00000198625MDM49350.000ENSUMAG00000020757MDM29432.609Ursus_maritimus
ENSG00000198625MDM410094.052ENSUMAG00000003452MDM410094.091Ursus_maritimus
ENSG00000198625MDM49231.702ENSVPAG00000007456MDM29732.370Vicugna_pacos
ENSG00000198625MDM49592.688ENSVPAG00000012034MDM49992.688Vicugna_pacos
ENSG00000198625MDM410093.182ENSVVUG00000014855MDM410093.089Vulpes_vulpes
ENSG00000198625MDM47854.444ENSXETG00000001434mdm29533.198Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II9226370.IDAProcess
GO:0003170heart valve development-ISSProcess
GO:0003181atrioventricular valve morphogenesis-ISSProcess
GO:0003203endocardial cushion morphogenesis-ISSProcess
GO:0003281ventricular septum development-ISSProcess
GO:0003283atrial septum development-ISSProcess
GO:0005515protein binding10469568.10608892.15604276.15916963.16227609.16510145.16511560.16511572.17080083.17110929.17159902.17875722.18356162.18566590.19255450.19521340.20515689.20705607.21988832.22493164.22902369.24667498.25416956.25609649.26871637.27107012.IPIFunction
GO:0005634nucleus-IDAComponent
GO:0005634nucleus9226370.NASComponent
GO:0005654nucleoplasm-TASComponent
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TASProcess
GO:0008270zinc ion binding10608892.TASFunction
GO:0008283cell proliferation12101245.IEPProcess
GO:0008285negative regulation of cell proliferation9226370.TASProcess
GO:0016579protein deubiquitination-TASProcess
GO:0019899enzyme binding19838211.IPIFunction
GO:0030330DNA damage response, signal transduction by p53 class mediator14660608.IEPProcess
GO:0042177negative regulation of protein catabolic process10608892.IMPProcess
GO:0043066negative regulation of apoptotic process-IEAProcess
GO:0045023G0 to G1 transition12101245.IEPProcess
GO:0050821protein stabilization10608892.IEPProcess
GO:0065003protein-containing complex assembly10608892.IDAProcess
GO:0071157negative regulation of cell cycle arrest-IEAProcess
GO:0071456cellular response to hypoxia20810912.IEPProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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