EuRBPDB

Ensembl ID

ENSG00000198625 (Gene tree)

Gene ID

4194

Gene Symbol

MDM4

Alias

MDMX|HDMX

Full Name

MDM4 regulator of p53

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Plus strand

Length

65,303 bases

Position

chr1:204,516,379-204,581,681

Accession

6974

Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]