EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18677113	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.	Cell Cycle	2008 Aug	Popowicz GM	-
28460439	Tumorigenesis promotes Mdm4-S overexpression.	Oncotarget	2017 Apr 18	Pant V	doi: 10.18632/oncotarget.15552.
22120712	Abnormal MDMX degradation in tumor cells due to ARF deficiency.	Oncogene	2012 Aug 9	Li X	doi: 10.1038/onc.2011.534
19946469	Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53.	Aging (Albany NY)	2009 Jan	Heminger K	-
26867771	The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.	Tumour Biol	2016 Aug	Gansmo LB	doi: 10.1007/s13277-016-4940-2
21084273	An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity.	Cancer Res	2010 Dec 1	Wynendaele J	doi: 10.1158/0008-5472.CAN-10-0527
14660608	MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis.	J Biol Chem	2004 Feb 27	Mancini F	-
18356162	Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.	J Biol Chem	2008 May 16	Lopez-Pajares V	doi: 10.1074/jbc.M710030200
17651783	High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.	Hum Pathol	2007 Oct	Valentin-Vega YA	-
16027727	Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.	Oncogene	2005 Nov 24	Steinman HA	-
18172009	Regulation of MDMX expression by mitogenic signaling.	Mol Cell Biol	2008 Mar	Gilkes DM	doi: 10.1128/MCB.01633-07
22490292	[Correlation of polymorphism rs1563828 in MDM4 gene with breast cancer risk and onset age].	Zhonghua Wai Ke Za Zhi	2012 Jan 1	Song CG	-
16616333	A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.	Cancer Cell	2006 Apr	Toledo F	-
22333590	Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.	Cell Cycle	2012 Mar 1	Dolezelova P	doi: 10.4161/cc.11.5.19445
28270148	MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.	Mol Cancer	2017 Mar 7	Mancini F	doi: 10.1186/s12943-017-0626-7.
28351930	Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate.	Clin Cancer Res	2017 Aug 1	Kato S	doi: 10.1158/1078-0432.CCR-16-3133
26471763	MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.	Cancer Med	2015 Dec	Gansmo LB	doi: 10.1002/cam4.555
26274820	A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer.	PLoS One	2015 Aug 14	Gao F	doi: 10.1371/journal.pone.0135647
26181202	Targeting Mdmx to treat breast cancers with wild-type p53.	Cell Death Dis	2015 Jul 16	Haupt S	doi: 10.1038/cddis.2015.173.
27738340	A PRISMA-compliant meta-analysis of MDM4 genetic variants and cancer susceptibility.	Oncotarget	2016 Nov 8	Zhai Y	doi: 10.18632/oncotarget.12558.
29697201	Mir-1307 regulates cisplatin resistance by targeting Mdm4 in breast cancer expressing wild type P53.	Thorac Cancer	2018 Jun	Wang X	doi: 10.1111/1759-7714.12607
18279506	Mutation analysis of the MDM4 gene in German breast cancer patients.	BMC Cancer	2008 Feb 15	Reincke S	doi: 10.1186/1471-2407-8-52.
25670033	A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.	Endocr Relat Cancer	2015 Apr	Stegeman S	doi: 10.1530/ERC-15-0013
21750655	A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.	Neoplasia	2011 Jul	Wang H	-
23793604	Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility.	Breast Cancer Res Treat	2013 Jul	Liu J	doi: 10.1007/s10549-013-2615-x
23994448	Identification and expression of a novel MDM4 splice variant in human glioma.	Brain Res	2013 Nov 6	Wang X	doi: 10.1016/j.brainres.2013.07.054
26416355	Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells.	Oncotarget	2015 Nov 3	Slabakova E	doi: 10.18632/oncotarget.5392.
19762336	A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.	Carcinogenesis	2009 Nov	Kulkarni DA	doi: 10.1093/carcin/bgp224
20855462	Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.	Clin Cancer Res	2010 Nov 1	Sun T	doi: 10.1158/1078-0432.CCR-10-1261
25026175	Copy number analysis of 24 oncogenes: MDM4 identified as a putative marker for low recurrence risk in non muscle invasive bladder cancer.	Int J Mol Sci	2014 Jul 14	Salvi S	doi: 10.3390/ijms150712458.
27798881	Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer.	Anticancer Res	2016 Oct	Kriegmair MC	-
21540763	Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck.	Pharmacogenet Genomics	2011 Jul	Yu H	doi: 10.1097/FPC.0b013e32834632e4.
27646776	The role of MDM4 SNP34091 A>C polymorphism in cancer: a meta-analysis on 19,328 patients and 51,058 controls.	Int J Biol Markers	2017 Mar 2	Jin X	doi: 10.5301/jbm.5000228.
27462918	Variations within 3'-UTR of MDM4 gene contribute to clinical outcomes of advanced non-small cell lung cancer patients following platinum-based chemotherapy.	Oncotarget	2017 Mar 7	Yang Y	doi: 10.18632/oncotarget.10771.
28097652	MDM4 is a rational target for treating breast cancers with mutant p53.	J Pathol	2017 Apr	Miranda PJ	doi: 10.1002/path.4877
28099948	MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.	Oncotarget	2017 Mar 21	Wang MY	doi: 10.18632/oncotarget.14666.
27742919	The associations between MDM4 gene polymorphisms and cancer risk.	Oncotarget	2016 Aug 23	Wang MJ	doi: 10.18632/oncotarget.10877.
27687591	MDM4 rs4245739 A > C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects.	Oncotarget	2016 Nov 1	Xu C	doi: 10.18632/oncotarget.12326.
28164646	Analysis of the Association between MDM4 rs4245739 Single Nucleotide Polymorphism and Breast Cancer Susceptibility.	Clin Lab	2016 Jul 1	Pedram N	doi: 10.7754/Clin.Lab.2016.151128.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	204542866	Silent	NA	L198L	0.35
BLCA	chr1	204525522	Missense_Mutation	novel	T2S	0.26
BLCA	chr1	204538206	Splice_Region	novel		0.18
BLCA	chr1	204532197	Silent	NA	L98L	0.29
BRCA	chr1	204537480	Missense_Mutation	NA	S132C	0.1
BRCA	chr1	204526424	Frame_Shift_Del	NA	*T48Sfs2**	0.16
BRCA	chr1	204544642	Silent	NA	T260T	0.2
BRCA	chr1	204538218	Missense_Mutation	NA	E141K	0.36
CHOL	chr1	204532784	Intron	novel		0.62
COAD	chr1	204549672	In_Frame_Ins	novel	F488_I489insC	0.07
COAD	chr1	204549320	Missense_Mutation	NA	V371I	0.41
COAD	chr1	204542943	Missense_Mutation	NA	Q224L	0.31
COAD	chr1	204542848	Silent	NA	E192E	0.39
COAD	chr1	204546825	Missense_Mutation	NA	L284P	0.19
COAD	chr1	204538264	Missense_Mutation	NA	P156H	0.07
COAD	chr1	204542879	Missense_Mutation	NA	L203I	0.1
COAD	chr1	204549692	3'UTR	rs755738645		0.41
COAD	chr1	204544651	Frame_Shift_Ins	novel	S264*	0.04
GBM	chr1	204525572	Missense_Mutation	novel	R18S	0.4
GBM	chr1	204538276	Missense_Mutation	NA	T160S	0.39
GBM	chr1	204549506	Missense_Mutation	novel	L433I	0.23
HNSC	chr1	204549314	Missense_Mutation	rs140091735	P369S	0.37
KIRP	chr1	204549864	3'UTR	novel		0.4
LGG	chr1	204549221	Missense_Mutation	NA	T338P	0.13
LUAD	chr1	204537937	Intron	novel		0.06
LUAD	chr1	204544567	Silent	novel	T235T	0.17
LUAD	chr1	204549160	Missense_Mutation	novel	K317N	0.27	zf-RanBP
LUAD	chr1	204549699	3'UTR	novel		0.08
LUAD	chr1	204549701	3'UTR	novel		0.09
LUAD	chr1	204526414	Missense_Mutation	novel	E45K	0.09
LUAD	chr1	204537458	Missense_Mutation	novel	Q124H	0.18
LUAD	chr1	204542883	Missense_Mutation	NA	G204V	0.19
LUSC	chr1	204544636	Silent	novel	A258A	0.24
LUSC	chr1	204549134	Missense_Mutation	novel	C309S	0.15	zf-RanBP
LUSC	chr1	204549118	Missense_Mutation	novel	E303D	0.12	zf-RanBP
OV	chr1	204544585	Missense_Mutation	NA	L241F	0.2
OV	chr1	204549126	Missense_Mutation	novel	C306S	0.03	zf-RanBP
OV	chr1	204549174	Missense_Mutation	novel	R322P	0.08	zf-RanBP
OV	chr1	204546829	Silent	NA	E285E	0.15
OV	chr1	204549183	Missense_Mutation	novel	A325V	0.05	zf-RanBP
OV	chr1	204549828	3'UTR	novel		0.17
PRAD	chr1	204532807	Intron	novel		0.41
PRAD	chr1	204544648	Missense_Mutation	NA	Q262H	0.31
READ	chr1	204549692	3'UTR	rs755738645		0.29
READ	chr1	204549309	Missense_Mutation	rs201947927	S367L	0.48
READ	chr1	204549132	Missense_Mutation	NA	E308A	0.11	zf-RanBP
SKCM	chr1	204532201	Missense_Mutation	NA	D100N	0.21
SKCM	chr1	204549719	3'UTR	novel		0.42
SKCM	chr1	204544632	Missense_Mutation	NA	A257V	0.42
SKCM	chr1	204538263	Missense_Mutation	novel	P156S	0.39
SKCM	chr1	204542864	Silent	NA	L198L	0.41
STAD	chr1	204532776	Intron	novel		0.22
STAD	chr1	204542834	Missense_Mutation	NA	L188F	0.14
STAD	chr1	204537493	Missense_Mutation	novel	L136P	0.25
STAD	chr1	204549320	Missense_Mutation	NA	V371I	0.26
STAD	chr1	204542939	Missense_Mutation	NA	N223D	0.48
STAD	chr1	204549692	3'UTR	rs755738645		0.29
STAD	chr1	204530706	Missense_Mutation	novel	Y59C	0.08
STAD	chr1	204537489	Missense_Mutation	NA	Q135K	0.23
THCA	chr1	204549784	3'UTR	novel		0.33
UCEC	chr1	204538257	Missense_Mutation	NA	D154N	0.37
UCEC	chr1	204530750	Missense_Mutation	NA	V74I	0.18
UCEC	chr1	204537991	Intron	NA		0.44
UCEC	chr1	204549238	Silent	rs770826577	T343T	0.17
UCEC	chr1	204549387	Missense_Mutation	NA	E393G	0.27
UCEC	chr1	204525504	5'UTR	NA		0.3
UCEC	chr1	204546856	Silent	rs773085031	T294T	0.36
UCEC	chr1	204537453	Missense_Mutation	rs145156544	A123T	0.22
UCEC	chr1	204537921	Intron	novel		0.27
UCEC	chr1	204549691	3'UTR	rs540436943		0.65
UCEC	chr1	204544554	Missense_Mutation	novel	V231A	0.09
UCEC	chr1	204549352	Missense_Mutation	novel	E381D	0.21
UCEC	chr1	204538256	Silent	rs775928214	D153D	0.16
UCEC	chr1	204549640	Silent	NA	C477C	0.2
UCEC	chr1	204544641	Missense_Mutation	novel	T260I	0.38
UCEC	chr1	204549681	Silent	novel	*491*	0.3
UCEC	chr1	204549557	Frame_Shift_Ins	novel	*I450Tfs38**	0.08
UCEC	chr1	204549495	In_Frame_Ins	novel	D429delinsESLWKV	0.13
UCEC	chr1	204549424	Missense_Mutation	novel	E405D	0.27
UCEC	chr1	204538305	Missense_Mutation	novel	E170K	0.15
UCEC	chr1	204549237	Missense_Mutation	novel	T343M	0.05
UCEC	chr1	204538257	Missense_Mutation	NA	D154N	0.3
UCEC	chr1	204526372	Silent	novel	L31L	0.09
UCEC	chr1	204542809	Silent	NA	A179A	0.13
UCEC	chr1	204549571	Silent	rs775939262	T454T	0.17
UCEC	chr1	204530740	Silent	novel	E70E	0.36
UCEC	chr1	204549190	Silent	novel	R327R	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0907	0.033566
DLBC	DEL	0.0417	0.0017831
GBM	AMP	0.2392	2.2156e-76
KIRC	AMP	0.089	0.059566
LGG	AMP	0.076	1.9242e-17
READ	AMP	0.2788	0.14328
TGCT	AMP	0.3533	0.088103
THCA	AMP	0.0481	0.075436

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0014	Kaplan-Meier Survival Analysis
KIRC	0.0013	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.0062	Kaplan-Meier Survival Analysis
SKCM	0.0063	Kaplan-Meier Survival Analysis
PRAD	0.0035	Kaplan-Meier Survival Analysis
COAD	0.022	Kaplan-Meier Survival Analysis
PAAD	0.031	Kaplan-Meier Survival Analysis
BLCA	0.0006	Kaplan-Meier Survival Analysis
LAML	0.00012	Kaplan-Meier Survival Analysis
GBM	0.0083	Kaplan-Meier Survival Analysis
LGG	0.0032	Kaplan-Meier Survival Analysis
LUAD	0.017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198625 (Gene tree)
Gene ID: 4194
Gene Symbol: MDM4
Alias: MDMX|HDMX
Full Name: MDM4 regulator of p53
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 65,303 bases
Position: chr1:204,516,379-204,581,681
Accession: 6974
RBP type: canonical RBP
Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000395254	zf-RanBP	PF00641.18	6.9e-09	1	1
ENSP00000478080	zf-RanBP	PF00641.18	2.3e-08	1	1
ENSP00000356147	zf-RanBP	PF00641.18	3.6e-08	1	1
ENSP00000482388	zf-RanBP	PF00641.18	3.9e-08	1	1
ENSP00000396840	zf-RanBP	PF00641.18	4.5e-08	1	1
ENSP00000356150	zf-RanBP	PF00641.18	5.1e-08	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28837642	Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.	PLoS One	2017 Aug 24	Kulp JL 3rd	doi: 10.1371/journal.pone.0183327
26867771	The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.	Tumour Biol	2016 Aug	Gansmo LB	doi: 10.1007/s13277-016-4940-2
26876197	Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.	Oncogene	2016 Sep 8	Xie X	doi: 10.1038/onc.2016.12

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000367182	MDM4-203	10073	XM_017001311	ENSP00000356150	490 (aa)	XP_016856800	O15151
ENST00000463049	MDM4-209	6102	-	-	- (aa)	-	-
ENST00000616250	MDM4-216	9597	-	ENSP00000478581	116 (aa)	-	A0A087WUE3
ENST00000614459	MDM4-215	9782	-	ENSP00000482388	392 (aa)	-	A0A087WZ58
ENST00000444261	MDM4-206	513	-	ENSP00000395254	171 (aa)	-	Q5T0Y3
ENST00000507825	MDM4-213	481	-	ENSP00000443816	140 (aa)	-	Q68DC0
ENST00000391947	MDM4-205	10008	-	ENSP00000375811	140 (aa)	-	Q68DC0
ENST00000471783	MDM4-212	552	-	-	- (aa)	-	-
ENST00000462012	MDM4-208	582	-	-	- (aa)	-	-
ENST00000470908	MDM4-211	884	-	-	- (aa)	-	-
ENST00000367180	MDM4-202	547	-	ENSP00000356148	131 (aa)	-	Q5T0Y4
ENST00000454264	MDM4-207	9926	XM_017001313	ENSP00000396840	440 (aa)	XP_016856802	O15151
ENST00000367183	MDM4-204	9098	-	ENSP00000356151	164 (aa)	-	O15151
ENST00000612738	MDM4-214	9407	-	ENSP00000478080	267 (aa)	-	A0A087WTR9
ENST00000367179	MDM4-201	697	-	ENSP00000356147	213 (aa)	-	Q5T0Y2
ENST00000470797	MDM4-210	909	-	-	- (aa)	-	-
ENST00000621032	MDM4-217	5592	-	ENSP00000482479	153 (aa)	-	Q6MZR7

Gene Model

Click here to download ENSG00000198625's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04115	p53 signaling pathway	KEGG
hsa05206	MicroRNAs in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198625	Neuropsychological Tests	5E-6	19734545
ENSG00000198625	Breast Neoplasms	8E-18	27117709
ENSG00000198625	Breast Neoplasms	1E-7	23544013
ENSG00000198625	Education	3E-9	27225129
ENSG00000198625	Triple Negative Breast Neoplasms	4E-6	24325915
ENSG00000198625	Prostatic Neoplasms	2E-11	23535732
ENSG00000198625	Breast Neoplasms	2E-12	23535733
ENSG00000198625	Breast Neoplasms	6E-15	27117709
ENSG00000198625	Education	5E-8	25201988
ENSG00000198625	Education	3E-13	27225129
ENSG00000198625	Education	8E-12	23722424

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198625	rs4245739	1	204549714	C	Breast cancer (estrogen-receptor negative)	29058716	[1.11-1.16]	1.14	EFO_1000650
ENSG00000198625	rs4245739	1	204549714	A	Systolic blood pressure	27618452	[0.19-0.46] mm Hg increase	0.326	EFO_0006335
ENSG00000198625	rs4245739	1	204549714	A	Diastolic blood pressure	27618452	[0.16-0.32] mm Hg increase	0.243	EFO_0006336
ENSG00000198625	rs4245739	1	204549714	?	Breast cancer	27117709	[1.05-1.14] (BRCA1 carriers)	1.09	EFO_0000305
ENSG00000198625	rs4245739	1	204549714	?	Breast cancer (estrogen-receptor negative)	27117709	[1.11-1.19]	1.13	EFO_1000650
ENSG00000198625	rs4245739	1	204549714	?	Breast cancer	23535733	[1.10-1.18]	1.14	EFO_0000305
ENSG00000198625	rs4245739	1	204549714	A	Prostate cancer	23535732	[1.05-1.14]	1.1	EFO_0001663
ENSG00000198625	rs2290854	1	204546897	A	Breast Cancer in BRCA1 mutation carriers	23544013	[1.08-1.18]	1.13	EFO_0000305
ENSG00000198625	rs4245739	1	204549714	?	Diastolic blood pressure (cigarette smoking interaction)	29455858			EFO_0006527\|EFO_0006336
ENSG00000198625	rs4252707	1	204539019	A	Non-glioblastoma glioma	28346443	1.12-1.26	1.19	EFO_0000326\|EFO_0005543
ENSG00000198625	rs1046874	1	204557932	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000198625	rs4245739	1	204549714	A	Prostate cancer	29892016	[1.08-1.12]	1.1	EFO_0001663

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198625's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198625	MDM4	93	50.000	ENSAMEG00000008526	MDM2	93	32.213	Ailuropoda_melanoleuca
ENSG00000198625	MDM4	100	94.545	ENSAMEG00000001126	MDM4	100	92.886	Ailuropoda_melanoleuca
ENSG00000198625	MDM4	92	34.328	ENSAPLG00000011164	MDM2	97	34.476	Anas_platyrhynchos
ENSG00000198625	MDM4	97	67.257	ENSACAG00000007350	-	100	57.637	Anolis_carolinensis
ENSG00000198625	MDM4	61	59.155	ENSACAG00000004204	MDM2	81	33.124	Anolis_carolinensis
ENSG00000198625	MDM4	90	31.174	ENSANAG00000027171	-	79	58.025	Aotus_nancymaae
ENSG00000198625	MDM4	100	97.004	ENSANAG00000036891	MDM4	100	97.004	Aotus_nancymaae
ENSG00000198625	MDM4	100	93.077	ENSANAG00000025757	-	100	83.673	Aotus_nancymaae
ENSG00000198625	MDM4	94	50.459	ENSBTAG00000010422	MDM2	94	32.460	Bos_taurus
ENSG00000198625	MDM4	100	91.324	ENSBTAG00000006255	MDM4	100	89.817	Bos_taurus
ENSG00000198625	MDM4	100	88.462	ENSBTAG00000054094	-	100	90.698	Bos_taurus
ENSG00000198625	MDM4	91	31.042	ENSCJAG00000042596	-	92	32.573	Callithrix_jacchus
ENSG00000198625	MDM4	69	54.930	ENSCJAG00000007464	-	61	58.025	Callithrix_jacchus
ENSG00000198625	MDM4	100	96.403	ENSCJAG00000016986	MDM4	100	96.330	Callithrix_jacchus
ENSG00000198625	MDM4	100	94.091	ENSCAFG00000009669	MDM4	100	93.496	Canis_familiaris
ENSG00000198625	MDM4	93	50.000	ENSCAFG00000000418	MDM2	88	32.298	Canis_familiaris
ENSG00000198625	MDM4	93	50.000	ENSCAFG00020017002	MDM2	94	31.992	Canis_lupus_dingo
ENSG00000198625	MDM4	98	82.099	ENSCAFG00020005984	MDM4	99	92.962	Canis_lupus_dingo
ENSG00000198625	MDM4	99	46.957	ENSCHIG00000019939	-	94	31.992	Capra_hircus
ENSG00000198625	MDM4	88	84.574	ENSCHIG00000027135	-	100	72.379	Capra_hircus
ENSG00000198625	MDM4	100	90.428	ENSCHIG00000010343	-	100	90.428	Capra_hircus
ENSG00000198625	MDM4	100	96.154	ENSTSYG00000010731	MDM4	100	96.154	Carlito_syrichta
ENSG00000198625	MDM4	69	60.606	ENSTSYG00000031248	-	85	60.870	Carlito_syrichta
ENSG00000198625	MDM4	90	92.593	ENSCAPG00000011380	MDM4	96	83.047	Cavia_aperea
ENSG00000198625	MDM4	95	89.247	ENSCPOG00000008227	MDM4	96	89.247	Cavia_porcellus
ENSG00000198625	MDM4	93	49.074	ENSCPOG00000004323	MDM2	94	31.493	Cavia_porcellus
ENSG00000198625	MDM4	70	54.930	ENSCCAG00000006745	-	69	58.025	Cebus_capucinus
ENSG00000198625	MDM4	98	98.246	ENSCCAG00000031000	MDM4	100	96.226	Cebus_capucinus
ENSG00000198625	MDM4	100	96.154	ENSCCAG00000035274	-	100	96.154	Cebus_capucinus
ENSG00000198625	MDM4	84	34.722	ENSCATG00000000265	-	82	34.359	Cercocebus_atys
ENSG00000198625	MDM4	100	100.000	ENSCATG00000027086	MDM4	100	100.000	Cercocebus_atys
ENSG00000198625	MDM4	67	60.345	ENSCATG00000045264	-	80	61.429	Cercocebus_atys
ENSG00000198625	MDM4	98	92.982	ENSCLAG00000011995	MDM4	100	88.798	Chinchilla_lanigera
ENSG00000198625	MDM4	99	47.826	ENSCLAG00000009877	MDM2	97	31.021	Chinchilla_lanigera
ENSG00000198625	MDM4	100	100.000	ENSCSAG00000014561	MDM4	100	97.959	Chlorocebus_sabaeus
ENSG00000198625	MDM4	92	31.712	ENSCSAG00000004244	MDM2	94	32.510	Chlorocebus_sabaeus
ENSG00000198625	MDM4	72	95.181	ENSCHOG00000013096	-	100	88.166	Choloepus_hoffmanni
ENSG00000198625	MDM4	98	78.261	ENSCHOG00000008147	-	78	95.122	Choloepus_hoffmanni
ENSG00000198625	MDM4	92	32.017	ENSCPBG00000013316	MDM2	97	33.265	Chrysemys_picta_bellii
ENSG00000198625	MDM4	67	60.345	ENSCANG00000034475	MDM2	80	61.429	Colobus_angolensis_palliatus
ENSG00000198625	MDM4	86	97.024	ENSCANG00000032288	MDM4	99	97.024	Colobus_angolensis_palliatus
ENSG00000198625	MDM4	98	47.368	ENSCGRG00001022261	Mdm2	99	31.335	Cricetulus_griseus_chok1gshd
ENSG00000198625	MDM4	100	84.018	ENSCGRG00001004339	Mdm4	100	83.537	Cricetulus_griseus_chok1gshd
ENSG00000198625	MDM4	100	84.018	ENSCGRG00000008463	Mdm4	100	83.537	Cricetulus_griseus_crigri
ENSG00000198625	MDM4	99	46.957	ENSCGRG00000017891	Mdm2	99	31.034	Cricetulus_griseus_crigri
ENSG00000198625	MDM4	99	47.826	ENSDNOG00000046929	-	90	33.333	Dasypus_novemcinctus
ENSG00000198625	MDM4	100	92.308	ENSDNOG00000000842	MDM4	100	89.431	Dasypus_novemcinctus
ENSG00000198625	MDM4	85	35.915	ENSDORG00000007222	Mdm2	99	34.074	Dipodomys_ordii
ENSG00000198625	MDM4	99	84.663	ENSDORG00000006873	Mdm4	99	84.663	Dipodomys_ordii
ENSG00000198625	MDM4	100	87.671	ENSETEG00000011245	MDM4	100	80.081	Echinops_telfairi
ENSG00000198625	MDM4	85	52.381	ENSETEG00000011183	MDM2	76	51.376	Echinops_telfairi
ENSG00000198625	MDM4	92	30.753	ENSEASG00005008055	-	94	32.150	Equus_asinus_asinus
ENSG00000198625	MDM4	100	96.347	ENSEASG00005011431	MDM4	100	94.705	Equus_asinus_asinus
ENSG00000198625	MDM4	92	32.017	ENSECAG00000013604	MDM2	94	32.848	Equus_caballus
ENSG00000198625	MDM4	100	96.347	ENSECAG00000004843	MDM4	100	94.705	Equus_caballus
ENSG00000198625	MDM4	100	82.028	ENSEEUG00000013912	MDM4	100	65.041	Erinaceus_europaeus
ENSG00000198625	MDM4	80	50.538	ENSEEUG00000013849	MDM2	53	58.824	Erinaceus_europaeus
ENSG00000198625	MDM4	90	60.952	ENSELUG00000011889	mdm4	100	45.873	Esox_lucius
ENSG00000198625	MDM4	92	50.467	ENSFCAG00000024456	MDM2	97	31.273	Felis_catus
ENSG00000198625	MDM4	100	94.977	ENSFCAG00000014851	MDM4	100	94.977	Felis_catus
ENSG00000198625	MDM4	88	43.750	ENSFDAG00000007913	-	97	31.898	Fukomys_damarensis
ENSG00000198625	MDM4	100	86.992	ENSFDAG00000021356	MDM4	100	86.992	Fukomys_damarensis
ENSG00000198625	MDM4	97	55.752	ENSGMOG00000016389	mdm4	99	43.701	Gadus_morhua
ENSG00000198625	MDM4	92	34.615	ENSGALG00000009942	MDM2	99	31.434	Gallus_gallus
ENSG00000198625	MDM4	61	57.746	ENSGAGG00000017565	-	70	34.677	Gopherus_agassizii
ENSG00000198625	MDM4	100	100.000	ENSGGOG00000012957	MDM4	100	100.000	Gorilla_gorilla
ENSG00000198625	MDM4	70	54.930	ENSGGOG00000012907	MDM2	71	58.025	Gorilla_gorilla
ENSG00000198625	MDM4	84	31.690	ENSHGLG00000016066	-	99	31.081	Heterocephalus_glaber_female
ENSG00000198625	MDM4	100	89.206	ENSHGLG00000007642	MDM4	100	89.206	Heterocephalus_glaber_female
ENSG00000198625	MDM4	92	30.228	ENSHGLG00000020526	-	92	32.252	Heterocephalus_glaber_female
ENSG00000198625	MDM4	98	47.368	ENSHGLG00000000856	-	94	32.460	Heterocephalus_glaber_female
ENSG00000198625	MDM4	77	49.074	ENSHGLG00100000441	-	92	32.394	Heterocephalus_glaber_male
ENSG00000198625	MDM4	100	88.821	ENSHGLG00100006704	-	100	88.821	Heterocephalus_glaber_male
ENSG00000198625	MDM4	92	58.974	ENSHCOG00000008924	mdm4	99	44.444	Hippocampus_comes
ENSG00000198625	MDM4	94	62.385	ENSIPUG00000024447	mdm4	100	46.479	Ictalurus_punctatus
ENSG00000198625	MDM4	99	48.696	ENSSTOG00000014702	-	94	32.025	Ictidomys_tridecemlineatus
ENSG00000198625	MDM4	99	87.671	ENSSTOG00000024007	-	100	79.226	Ictidomys_tridecemlineatus
ENSG00000198625	MDM4	100	91.039	ENSSTOG00000004184	MDM4	100	91.039	Ictidomys_tridecemlineatus
ENSG00000198625	MDM4	98	90.351	ENSJJAG00000017144	Mdm4	100	83.707	Jaculus_jaculus
ENSG00000198625	MDM4	92	33.680	ENSLACG00000010207	MDM2	94	34.809	Latimeria_chalumnae
ENSG00000198625	MDM4	91	51.351	ENSLAFG00000005885	MDM2	94	33.333	Loxodonta_africana
ENSG00000198625	MDM4	100	89.954	ENSLAFG00000002169	MDM4	100	87.169	Loxodonta_africana
ENSG00000198625	MDM4	67	60.345	ENSMFAG00000042359	MDM2	80	61.429	Macaca_fascicularis
ENSG00000198625	MDM4	100	100.000	ENSMFAG00000033606	MDM4	100	100.000	Macaca_fascicularis
ENSG00000198625	MDM4	100	100.000	ENSMMUG00000011236	MDM4	100	100.000	Macaca_mulatta
ENSG00000198625	MDM4	70	54.930	ENSMMUG00000014193	MDM2	94	33.255	Macaca_mulatta
ENSG00000198625	MDM4	100	100.000	ENSMNEG00000026547	MDM4	100	100.000	Macaca_nemestrina
ENSG00000198625	MDM4	67	60.345	ENSMNEG00000041135	MDM2	80	61.429	Macaca_nemestrina
ENSG00000198625	MDM4	100	100.000	ENSMLEG00000032041	MDM4	100	100.000	Mandrillus_leucophaeus
ENSG00000198625	MDM4	67	60.345	ENSMLEG00000042099	MDM2	80	61.429	Mandrillus_leucophaeus
ENSG00000198625	MDM4	100	30.222	ENSMGAG00000010513	MDM2	99	36.111	Meleagris_gallopavo
ENSG00000198625	MDM4	98	73.292	ENSMAUG00000009703	-	90	85.514	Mesocricetus_auratus
ENSG00000198625	MDM4	98	73.292	ENSMAUG00000017821	-	92	85.514	Mesocricetus_auratus
ENSG00000198625	MDM4	98	97.368	ENSMICG00000017021	MDM4	100	92.464	Microcebus_murinus
ENSG00000198625	MDM4	99	46.087	ENSMICG00000029037	-	90	31.155	Microcebus_murinus
ENSG00000198625	MDM4	94	48.624	ENSMOCG00000008043	Mdm2	94	31.458	Microtus_ochrogaster
ENSG00000198625	MDM4	100	86.239	ENSMOCG00000002099	Mdm4	100	85.336	Microtus_ochrogaster
ENSG00000198625	MDM4	89	89.320	ENSMODG00000001605	MDM4	100	76.056	Monodelphis_domestica
ENSG00000198625	MDM4	92	34.672	ENSMODG00000007219	-	94	34.979	Monodelphis_domestica
ENSG00000198625	MDM4	91	64.865	ENSMALG00000020663	mdm4	99	46.535	Monopterus_albus
ENSG00000198625	MDM4	98	87.719	MGP_CAROLIEiJ_G0014593	Mdm4	100	83.910	Mus_caroli
ENSG00000198625	MDM4	81	39.516	MGP_CAROLIEiJ_G0015836	Mdm2	99	30.268	Mus_caroli
ENSG00000198625	MDM4	98	87.719	ENSMUSG00000054387	Mdm4	100	83.910	Mus_musculus
ENSG00000198625	MDM4	78	46.789	ENSMUSG00000020184	Mdm2	99	31.499	Mus_musculus
ENSG00000198625	MDM4	78	46.789	MGP_PahariEiJ_G0031251	Mdm2	99	31.335	Mus_pahari
ENSG00000198625	MDM4	98	85.965	MGP_PahariEiJ_G0027829	Mdm4	100	82.857	Mus_pahari
ENSG00000198625	MDM4	83	46.789	MGP_SPRETEiJ_G0016659	Mdm2	99	31.731	Mus_spretus
ENSG00000198625	MDM4	98	87.719	MGP_SPRETEiJ_G0015400	Mdm4	100	83.707	Mus_spretus
ENSG00000198625	MDM4	98	48.246	ENSMPUG00000017505	MDM2	94	32.520	Mustela_putorius_furo
ENSG00000198625	MDM4	100	91.855	ENSMPUG00000011721	MDM4	100	91.075	Mustela_putorius_furo
ENSG00000198625	MDM4	100	85.388	ENSMLUG00000007129	MDM4	100	81.301	Myotis_lucifugus
ENSG00000198625	MDM4	99	50.435	ENSMLUG00000009997	MDM2	98	32.490	Myotis_lucifugus
ENSG00000198625	MDM4	100	88.391	ENSNGAG00000012344	Mdm4	100	88.391	Nannospalax_galili
ENSG00000198625	MDM4	99	46.957	ENSNGAG00000012154	Mdm2	94	33.888	Nannospalax_galili
ENSG00000198625	MDM4	100	100.000	ENSNLEG00000014271	MDM4	100	100.000	Nomascus_leucogenys
ENSG00000198625	MDM4	70	54.930	ENSNLEG00000003757	MDM2	94	33.647	Nomascus_leucogenys
ENSG00000198625	MDM4	93	89.815	ENSMEUG00000012624	-	85	76.744	Notamacropus_eugenii
ENSG00000198625	MDM4	95	90.108	ENSOPRG00000013878	MDM4	100	90.108	Ochotona_princeps
ENSG00000198625	MDM4	99	46.957	ENSOPRG00000009677	MDM2	98	31.369	Ochotona_princeps
ENSG00000198625	MDM4	92	30.687	ENSODEG00000000416	-	83	53.750	Octodon_degus
ENSG00000198625	MDM4	100	89.409	ENSODEG00000013499	MDM4	100	89.409	Octodon_degus
ENSG00000198625	MDM4	99	45.385	ENSODEG00000004028	-	99	33.465	Octodon_degus
ENSG00000198625	MDM4	98	45.614	ENSODEG00000006648	-	56	51.765	Octodon_degus
ENSG00000198625	MDM4	98	31.172	ENSOANG00000005942	MDM2	100	34.130	Ornithorhynchus_anatinus
ENSG00000198625	MDM4	90	88.889	ENSOANG00000013464	MDM4	100	72.650	Ornithorhynchus_anatinus
ENSG00000198625	MDM4	100	90.868	ENSOCUG00000000005	MDM4	100	89.817	Oryctolagus_cuniculus
ENSG00000198625	MDM4	92	42.537	ENSOCUG00000010899	-	60	32.465	Oryctolagus_cuniculus
ENSG00000198625	MDM4	99	47.826	ENSOCUG00000011354	-	94	33.058	Oryctolagus_cuniculus
ENSG00000198625	MDM4	92	31.866	ENSOGAG00000034779	MDM2	95	32.924	Otolemur_garnettii
ENSG00000198625	MDM4	65	54.930	ENSOGAG00000011845	-	95	32.665	Otolemur_garnettii
ENSG00000198625	MDM4	98	92.982	ENSOGAG00000011679	MDM4	100	89.091	Otolemur_garnettii
ENSG00000198625	MDM4	83	48.624	ENSOARG00000013821	-	94	31.864	Ovis_aries
ENSG00000198625	MDM4	100	90.020	ENSOARG00000002783	-	100	90.020	Ovis_aries
ENSG00000198625	MDM4	83	48.624	ENSOARG00000000570	-	93	31.537	Ovis_aries
ENSG00000198625	MDM4	100	100.000	ENSPPAG00000030518	MDM4	100	100.000	Pan_paniscus
ENSG00000198625	MDM4	70	54.930	ENSPPAG00000032775	MDM2	71	58.025	Pan_paniscus
ENSG00000198625	MDM4	92	50.467	ENSPPRG00000000082	MDM2	97	31.385	Panthera_pardus
ENSG00000198625	MDM4	100	94.977	ENSPPRG00000025076	MDM4	100	94.977	Panthera_pardus
ENSG00000198625	MDM4	92	50.467	ENSPTIG00000016929	MDM2	97	31.273	Panthera_tigris_altaica
ENSG00000198625	MDM4	100	94.570	ENSPTIG00000011372	MDM4	100	90.650	Panthera_tigris_altaica
ENSG00000198625	MDM4	100	100.000	ENSPTRG00000001889	MDM4	100	100.000	Pan_troglodytes
ENSG00000198625	MDM4	70	54.930	ENSPTRG00000005203	MDM2	71	58.025	Pan_troglodytes
ENSG00000198625	MDM4	100	100.000	ENSPANG00000008555	MDM4	100	100.000	Papio_anubis
ENSG00000198625	MDM4	67	60.345	ENSPANG00000005563	MDM2	80	61.429	Papio_anubis
ENSG00000198625	MDM4	92	32.059	ENSPSIG00000016379	-	100	33.264	Pelodiscus_sinensis
ENSG00000198625	MDM4	100	87.215	ENSPEMG00000018483	Mdm4	100	85.569	Peromyscus_maniculatus_bairdii
ENSG00000198625	MDM4	97	87.611	ENSPCIG00000017446	MDM4	100	74.291	Phascolarctos_cinereus
ENSG00000198625	MDM4	92	34.038	ENSPCIG00000005357	-	69	61.728	Phascolarctos_cinereus
ENSG00000198625	MDM4	92	32.189	ENSPPYG00000004754	MDM2	93	32.724	Pongo_abelii
ENSG00000198625	MDM4	100	98.980	ENSPPYG00000000315	MDM4	100	98.980	Pongo_abelii
ENSG00000198625	MDM4	100	84.932	ENSPCAG00000007019	MDM4	100	78.455	Procavia_capensis
ENSG00000198625	MDM4	93	50.459	ENSPCAG00000008949	MDM2	93	33.747	Procavia_capensis
ENSG00000198625	MDM4	98	98.246	ENSPCOG00000024397	MDM4	100	96.154	Propithecus_coquereli
ENSG00000198625	MDM4	89	31.808	ENSPCOG00000018521	-	88	58.929	Propithecus_coquereli
ENSG00000198625	MDM4	99	45.217	ENSPVAG00000006202	MDM2	98	30.829	Pteropus_vampyrus
ENSG00000198625	MDM4	100	88.584	ENSPVAG00000005663	MDM4	100	82.281	Pteropus_vampyrus
ENSG00000198625	MDM4	92	30.983	ENSRNOG00000006304	Mdm2	94	31.875	Rattus_norvegicus
ENSG00000198625	MDM4	100	84.932	ENSRNOG00000009696	Mdm4	100	83.943	Rattus_norvegicus
ENSG00000198625	MDM4	100	100.000	ENSRBIG00000038824	MDM4	100	100.000	Rhinopithecus_bieti
ENSG00000198625	MDM4	70	54.930	ENSRBIG00000028561	MDM2	94	33.255	Rhinopithecus_bieti
ENSG00000198625	MDM4	100	100.000	ENSRROG00000027771	MDM4	100	100.000	Rhinopithecus_roxellana
ENSG00000198625	MDM4	68	59.016	ENSRROG00000045589	-	81	60.274	Rhinopithecus_roxellana
ENSG00000198625	MDM4	99	96.154	ENSSBOG00000020446	-	99	96.154	Saimiri_boliviensis_boliviensis
ENSG00000198625	MDM4	66	60.377	ENSSBOG00000014544	-	76	62.000	Saimiri_boliviensis_boliviensis
ENSG00000198625	MDM4	100	97.753	ENSSBOG00000036183	-	100	97.753	Saimiri_boliviensis_boliviensis
ENSG00000198625	MDM4	97	86.726	ENSSHAG00000007767	MDM4	100	76.016	Sarcophilus_harrisii
ENSG00000198625	MDM4	92	33.612	ENSSHAG00000010284	-	94	34.350	Sarcophilus_harrisii
ENSG00000198625	MDM4	60	61.429	ENSSHAG00000000124	-	92	32.412	Sarcophilus_harrisii
ENSG00000198625	MDM4	96	61.261	ENSSFOG00015001112	mdm4	100	48.509	Scleropages_formosus
ENSG00000198625	MDM4	79	53.261	ENSSARG00000005801	MDM2	98	31.287	Sorex_araneus
ENSG00000198625	MDM4	100	85.654	ENSSARG00000004179	MDM4	100	82.688	Sorex_araneus
ENSG00000198625	MDM4	94	47.706	ENSSPUG00000000964	MDM2	95	34.012	Sphenodon_punctatus
ENSG00000198625	MDM4	98	97.368	ENSSSCG00000015284	MDM4	99	93.075	Sus_scrofa
ENSG00000198625	MDM4	99	46.957	ENSSSCG00000000488	MDM2	99	30.705	Sus_scrofa
ENSG00000198625	MDM4	100	51.364	ENSTGUG00000017483	MDM4	100	57.632	Taeniopygia_guttata
ENSG00000198625	MDM4	94	32.405	ENSTGUG00000006836	MDM2	99	34.783	Taeniopygia_guttata
ENSG00000198625	MDM4	89	86.772	ENSTBEG00000011684	MDM4	76	86.039	Tupaia_belangeri
ENSG00000198625	MDM4	82	35.252	ENSTBEG00000013758	MDM2	53	31.873	Tupaia_belangeri
ENSG00000198625	MDM4	76	46.809	ENSTTRG00000015715	MDM2	78	46.809	Tursiops_truncatus
ENSG00000198625	MDM4	100	92.806	ENSTTRG00000012174	MDM4	100	89.817	Tursiops_truncatus
ENSG00000198625	MDM4	100	94.091	ENSUAMG00000007328	MDM4	100	92.683	Ursus_americanus
ENSG00000198625	MDM4	93	50.000	ENSUAMG00000018322	-	98	32.096	Ursus_americanus
ENSG00000198625	MDM4	93	50.000	ENSUMAG00000020757	MDM2	94	32.609	Ursus_maritimus
ENSG00000198625	MDM4	100	94.052	ENSUMAG00000003452	MDM4	100	94.091	Ursus_maritimus
ENSG00000198625	MDM4	92	31.702	ENSVPAG00000007456	MDM2	97	32.370	Vicugna_pacos
ENSG00000198625	MDM4	95	92.688	ENSVPAG00000012034	MDM4	99	92.688	Vicugna_pacos
ENSG00000198625	MDM4	100	93.182	ENSVVUG00000014855	MDM4	100	93.089	Vulpes_vulpes
ENSG00000198625	MDM4	78	54.444	ENSXETG00000001434	mdm2	95	33.198	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	9226370.	IDA	Process
GO:0003170	heart valve development	-	ISS	Process
GO:0003181	atrioventricular valve morphogenesis	-	ISS	Process
GO:0003203	endocardial cushion morphogenesis	-	ISS	Process
GO:0003281	ventricular septum development	-	ISS	Process
GO:0003283	atrial septum development	-	ISS	Process
GO:0005515	protein binding	10469568.10608892.15604276.15916963.16227609.16510145.16511560.16511572.17080083.17110929.17159902.17875722.18356162.18566590.19255450.19521340.20515689.20705607.21988832.22493164.22902369.24667498.25416956.25609649.26871637.27107012.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	9226370.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	Process
GO:0008270	zinc ion binding	10608892.	TAS	Function
GO:0008283	cell proliferation	12101245.	IEP	Process
GO:0008285	negative regulation of cell proliferation	9226370.	TAS	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0019899	enzyme binding	19838211.	IPI	Function
GO:0030330	DNA damage response, signal transduction by p53 class mediator	14660608.	IEP	Process
GO:0042177	negative regulation of protein catabolic process	10608892.	IMP	Process
GO:0043066	negative regulation of apoptotic process	-	IEA	Process
GO:0045023	G0 to G1 transition	12101245.	IEP	Process
GO:0050821	protein stabilization	10608892.	IEP	Process
GO:0065003	protein-containing complex assembly	10608892.	IDA	Process
GO:0071157	negative regulation of cell cycle arrest	-	IEA	Process
GO:0071456	cellular response to hypoxia	20810912.	IEP	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.