EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19020731	Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.	Oncol Rep	2008 Dec	Wang Y	-
15183196	Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins.	Free Radic Biol Med	2004 Jul 1	Furman C	-
24583460	Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.	Free Radic Biol Med	2014 May	Duan D	doi: 10.1016/j.freeradbiomed.2014.02.016
21206984	Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.	Oncol Rep	2011 Mar	Iwasawa S	doi: 10.3892/or.2010.1131
20584310	Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.	Breast Cancer Res	2010	Cadenas C	doi: 10.1186/bcr2599
20920480	Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction.	Biochem Pharmacol	2011 Jan 15	Poerschke RL	doi: 10.1016/j.bcp.2010.09.024
24407164	Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.	Free Radic Biol Med	2014 Apr	Duan D	doi: 10.1016/j.freeradbiomed.2013.12.027
27381867	Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase.	Biochem Biophys Res Commun	2016 Sep 9	Jayakumar S	doi: 10.1016/j.bbrc.2016.06.144
28218611	Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.	Gen Physiol Biophys	2017 Apr	Hwang-Bo H	doi: 10.4149/gpb_2016043
26919094	Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.	Oncotarget	2016 Mar 29	Chen W	doi: 10.18632/oncotarget.7565.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	104287381	Intron	novel		0.24
BLCA	chr12	104327661	Missense_Mutation	novel	S511F	0.45
BLCA	chr12	104331600	Missense_Mutation	NA	E537K	0.25
BLCA	chr12	104348497	3'UTR	novel		0.16
BLCA	chr12	104325385	Nonsense_Mutation	NA	Q422*	0.21
BLCA	chr12	104321286	Missense_Mutation	novel	I395M	0.24
BLCA	chr12	104215815	Missense_Mutation	NA	E5K	0.67
BRCA	chr12	104287070	Intron	novel		0.2
BRCA	chr12	104289013	Missense_Mutation	rs773469710	K129N	0.15
BRCA	chr12	104319557	Missense_Mutation	NA	P321S	0.44
BRCA	chr12	104287130	Intron	novel		0.1
CESC	chr12	104288907	Intron	NA		0.38
CESC	chr12	104251667	Missense_Mutation	rs769989720	R78C	0.43
CESC	chr12	104339142	Missense_Mutation	rs369684801	R584C	0.42
CESC	chr12	104251610	Missense_Mutation	novel	L59F	0.42
CESC	chr12	104287292	Intron	novel		0.16
CESC	chr12	104325429	Splice_Region	rs771896901	T436T	0.24
CESC	chr12	104331600	Missense_Mutation	NA	E537Q	0.07
CESC	chr12	104334334	Splice_Site	novel	X582_splice	0.36
COAD	chr12	104325401	Missense_Mutation	NA	E427V	0.18
COAD	chr12	104319056	Splice_Site	NA	X291_splice	0.34
COAD	chr12	104321095	Missense_Mutation	novel	D332Y	0.18
COAD	chr12	104319495	Missense_Mutation	NA	K300T	0.24
COAD	chr12	104321304	Silent	rs547545865	F401F	0.19
COAD	chr12	104348411	Missense_Mutation	NA	C647Y	0.31
COAD	chr12	104287273	Intron	novel		0.22
COAD	chr12	104319486	Missense_Mutation	NA	G297D	0.25
COAD	chr12	104258038	Missense_Mutation	novel	S88Y	0.1
COAD	chr12	104318982	Missense_Mutation	rs189358801	R267Q	0.25
COAD	chr12	104319496	Missense_Mutation	novel	K300N	0.1
COAD	chr12	104289022	Silent	novel	G132G	0.17
COAD	chr12	104319552	Missense_Mutation	NA	G319D	0.21
ESCA	chr12	104288953	Silent	novel	G109G	0.34
ESCA	chr12	104315799	Missense_Mutation	novel	N211K	0.2
ESCA	chr12	104348355	Splice_Region	novel	V628V	0.25
ESCA	chr12	104289014	Missense_Mutation	novel	I130L	0.65
GBM	chr12	104327638	Silent	NA	L503L	0.31
GBM	chr12	104319582	Frame_Shift_Del	novel	*S329Tfs36**	0.07
GBM	chr12	104321196	Silent	rs201777096	D365D	0.74
GBM	chr12	104318931	Missense_Mutation	novel	R250I	0.11
GBM	chr12	104311306	Missense_Mutation	NA	R144K	0.33
HNSC	chr12	104288952	Missense_Mutation	novel	G109E	0.29
HNSC	chr12	104311353	Missense_Mutation	novel	S160P	0.26
HNSC	chr12	104339207	Silent	rs764327204	A605A	0.22
HNSC	chr12	104331601	Missense_Mutation	novel	E537G	0.15
HNSC	chr12	104319047	Missense_Mutation	novel	R289W	0.11
HNSC	chr12	104251546	Silent	novel	G37G	0.26
KIRP	chr12	104325428	Missense_Mutation	rs144671274	T436M	0.04
KIRP	chr12	104287305	Intron	novel		0.28
KIRP	chr12	104327672	Splice_Site	novel	X514_splice	0.39
KIRP	chr12	104287347	Intron	novel		0.28
LGG	chr12	104287389	Intron	novel		0.09
LIHC	chr12	104288928	Splice_Region	novel		0.46
LIHC	chr12	104251628	Missense_Mutation	NA	G65S	0.23
LUAD	chr12	104311357	Missense_Mutation	rs780170129	Y161C	0.29
LUAD	chr12	104331589	Missense_Mutation	novel	C533Y	0.34
LUAD	chr12	104251538	Missense_Mutation	novel	H35N	0.25
LUAD	chr12	104251625	Missense_Mutation	NA	D64Y	0.35
LUSC	chr12	104319008	Frame_Shift_Del	novel	*V276Mfs88**	0.53
LUSC	chr12	104288927	Splice_Region	novel		0.16
LUSC	chr12	104215815	Missense_Mutation	NA	E5K	0.75
LUSC	chr12	104288954	Missense_Mutation	novel	T110A	0.04
LUSC	chr12	104287384	Intron	novel		0.3
LUSC	chr12	104327668	Silent	NA	V513V	0.12
LUSC	chr12	104287330	Intron	novel		0.28
LUSC	chr12	104251561	Missense_Mutation	rs773611266	E42D	0.26
LUSC	chr12	104287418	Intron	novel		0.09
LUSC	chr12	104288902	Intron	novel		0.26
LUSC	chr12	104315801	Frame_Shift_Ins	novel	*C214Lfs4**	0.68
OV	chr12	104288971	Silent	novel	A115A	0.13
OV	chr12	104287413	Intron	novel		0.05
OV	chr12	104288923	Splice_Region	novel		0.29
OV	chr12	104288894	Intron	novel		0.07
OV	chr12	104348603	3'UTR	novel		0.6
PAAD	chr12	104288947	Silent	novel	L107L	0.16
PCPG	chr12	104319574	Silent	novel	Y326Y	0.21
PRAD	chr12	104331567	Missense_Mutation	novel	T526P	0.35
PRAD	chr12	104348353	Missense_Mutation	NA	V628L	0.37
PRAD	chr12	104315896	Missense_Mutation	novel	V244L	0.48
PRAD	chr12	104327655	Missense_Mutation	novel	A509V	0.41
READ	chr12	104326381	Missense_Mutation	novel	R448K	0.23
READ	chr12	104251667	Missense_Mutation	rs769989720	R78C	0.37
READ	chr12	104315890	Nonsense_Mutation	novel	E242*	0.06
SARC	chr12	104288972	Missense_Mutation	novel	A116S	0.2
SARC	chr12	104321126	Missense_Mutation	novel	K342M	0.26
SARC	chr12	104321127	Silent	novel	K342K	0.26
SARC	chr12	104326386	Missense_Mutation	novel	I450F	0.36
SARC	chr12	104331630	Missense_Mutation	novel	E547K	0.08
SKCM	chr12	104251532	Missense_Mutation	NA	D33N	0.29
SKCM	chr12	104311368	Missense_Mutation	NA	L165F	0.12
SKCM	chr12	104348398	Missense_Mutation	NA	L643F	0.26
SKCM	chr12	104315805	Silent	novel	G213G	0.37
SKCM	chr12	104287386	Intron	novel		0.26
SKCM	chr12	104318981	Nonsense_Mutation	novel	R267*	0.21
SKCM	chr12	104348465	3'UTR	rs746979328		0.34
SKCM	chr12	104288980	Silent	NA	T118T	0.32
SKCM	chr12	104319540	Missense_Mutation	NA	P315L	0.52
STAD	chr12	104321284	Missense_Mutation	novel	I395F	0.11
STAD	chr12	104339153	Silent	novel	G587G	0.17
STAD	chr12	104339275	Splice_Site	NA	X627_splice	0.13
STAD	chr12	104289021	Missense_Mutation	NA	G132D	0.22
STAD	chr12	104311389	Missense_Mutation	NA	S172P	0.24
STAD	chr12	104348471	3'UTR	rs372958394		0.27
STAD	chr12	104348393	Missense_Mutation	NA	S641N	0.18
STAD	chr12	104287348	Intron	novel		0.33
STAD	chr12	104287118	Intron	novel		0.3
STAD	chr12	104288969	Missense_Mutation	NA	A115S	0.3
TGCT	chr12	104315782	Missense_Mutation	rs370602169	G206R	0.04
UCEC	chr12	104258038	Missense_Mutation	NA	S88F	0.26
UCEC	chr12	104339240	Missense_Mutation	novel	D616E	0.36
UCEC	chr12	104311334	Silent	novel	G153G	0.23
UCEC	chr12	104348489	3'UTR	novel		0.06
UCEC	chr12	104319511	Silent	novel	E305E	0.35
UCEC	chr12	104325345	Silent	novel	Q408Q	0.36
UCEC	chr12	104326401	Missense_Mutation	rs201533043	V455I	0.36
UCEC	chr12	104331630	Nonsense_Mutation	NA	E547*	0.35
UCEC	chr12	104258148	Intron	novel		0.37
UCEC	chr12	104215888	Missense_Mutation	novel	R29K	0.58
UCEC	chr12	104321155	Missense_Mutation	novel	A352T	0.42
UCEC	chr12	104349475	3'UTR	novel		0.47
UCEC	chr12	104348603	3'UTR	novel		0.13
UCEC	chr12	104327671	Missense_Mutation	NA	K514N	0.19
UCEC	chr12	104251544	Missense_Mutation	novel	G37C	0.09
UCEC	chr12	104258216	Intron	novel		0.33
UCEC	chr12	104258026	Missense_Mutation	novel	K84T	0.33
UCEC	chr12	104315795	Missense_Mutation	novel	V210A	0.39
UCEC	chr12	104310079	Intron	novel		0.38
UCEC	chr12	104251628	Missense_Mutation	NA	G65S	0.35
UCEC	chr12	104339166	Missense_Mutation	rs557961762	G592S	0.43
UCEC	chr12	104224893	Intron	novel		0.35
UCEC	chr12	104331614	Silent	novel	V541V	0.3
UCEC	chr12	104334295	Missense_Mutation	novel	K570R	0.39
UCEC	chr12	104311356	Missense_Mutation	novel	Y161H	0.26
UCEC	chr12	104331587	Silent	novel	A532A	0.46
UCEC	chr12	104309850	Intron	novel		0.36
UCEC	chr12	104349641	3'UTR	novel		0.27
UCEC	chr12	104348439	3'UTR	novel		0.14
UCEC	chr12	104348603	3'UTR	novel		0.67
UCEC	chr12	104258024	Missense_Mutation	novel	K83N	0.44
UCEC	chr12	104287424	Intron	novel		0.13
UCEC	chr12	104318982	Missense_Mutation	rs189358801	R267Q	0.35
UCEC	chr12	104326412	Missense_Mutation	novel	K458N	0.14
UCEC	chr12	104315867	Missense_Mutation	NA	R234Q	0.34
UCEC	chr12	104331600	Missense_Mutation	NA	E537Q	0.15
UCEC	chr12	104287403	Intron	novel		0.43
UCEC	chr12	104251553	Silent	NA	L40L	0.31
UCEC	chr12	104311369	Missense_Mutation	novel	L165R	0.14
UCEC	chr12	104321155	Missense_Mutation	novel	A352T	0.1
UCEC	chr12	104251602	Missense_Mutation	NA	R56I	0.15
UCEC	chr12	104319486	Missense_Mutation	NA	G297D	0.35
UCEC	chr12	104348411	Missense_Mutation	NA	C647Y	0.32
UCEC	chr12	104319491	Nonsense_Mutation	NA	E299*	0.36
UCEC	chr12	104251551	Missense_Mutation	novel	T39N	0.3
UCEC	chr12	104319052	Missense_Mutation	novel	I290M	0.06
UCEC	chr12	104311306	Missense_Mutation	rs368264904	R144I	0.21
UCEC	chr12	104319506	Missense_Mutation	novel	A304T	0.1
UCEC	chr12	104321283	Silent	novel	G394G	0.38
UCEC	chr12	104258135	Intron	novel		0.36
UCEC	chr12	104334278	Silent	rs562593393	P564P	0.5
UCEC	chr12	104319525	Missense_Mutation	NA	A310V	0.22
UCEC	chr12	104321249	Missense_Mutation	NA	A383V	0.12
UCEC	chr12	104319543	Missense_Mutation	rs377062126	R316H	0.28
UCEC	chr12	104287191	Intron	novel		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0333	0.20414
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0613	0.22646
LUAD	DEL	0.1492	0.0059643
LUSC	DEL	0.0938	0.038823
PAAD	DEL	0.1848	0.0030251
PRAD	AMP	0.0589	0.016187
READ	DEL	0.103	0.064633
SKCM	DEL	0.1989	0.00079981

Survival Analysis

Cancer	P-value	Q-value
ACC	0.03	Kaplan-Meier Survival Analysis
HNSC	0.021	Kaplan-Meier Survival Analysis
BRCA	0.024	Kaplan-Meier Survival Analysis
KIRP	0.00052	Kaplan-Meier Survival Analysis
BLCA	0.045	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
KICH	0.035	Kaplan-Meier Survival Analysis
UCEC	0.041	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
CHOL	0.0067	Kaplan-Meier Survival Analysis
THCA	0.0049	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.0057	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000198431 (Gene tree)
Gene ID: 7296
Gene Symbol: TXNRD1
Alias: TXNR|GRIM-12|Trxr1
Full Name: thioredoxin reductase 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 134,529 bases
Position: chr12:104,215,779-104,350,307
Accession: 12437
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000531689	TXNRD1-222	554	-	ENSP00000433507	72 (aa)	-	E9PKI4
ENST00000524698	TXNRD1-206	1933	-	ENSP00000433425	499 (aa)	-	Q16881
ENST00000429002	TXNRD1-204	3855	-	ENSP00000412045	648 (aa)	-	A0A087WSY9
ENST00000527335	TXNRD1-216	786	-	ENSP00000433599	175 (aa)	-	E9PKD3
ENST00000526006	TXNRD1-209	502	-	-	- (aa)	-	-
ENST00000526207	TXNRD1-210	551	-	-	- (aa)	-	-
ENST00000354940	TXNRD1-201	4082	-	ENSP00000347020	498 (aa)	-	F8W809
ENST00000525566	TXNRD1-208	3836	-	ENSP00000434516	649 (aa)	-	Q16881
ENST00000529784	TXNRD1-221	607	-	ENSP00000436229	53 (aa)	-	E9PQI3
ENST00000388854	TXNRD1-202	4277	-	ENSP00000373506	548 (aa)	-	A0A087WSW9
ENST00000526266	TXNRD1-211	577	-	ENSP00000431294	70 (aa)	-	E9PLT3
ENST00000534282	TXNRD1-224	488	-	-	- (aa)	-	-
ENST00000527688	TXNRD1-217	3858	-	ENSP00000433935	482 (aa)	-	E9PIR7
ENST00000526691	TXNRD1-214	3974	-	ENSP00000435929	551 (aa)	-	Q16881
ENST00000531691	TXNRD1-223	728	-	ENSP00000431925	139 (aa)	-	E9PIZ5
ENST00000529751	TXNRD1-220	557	-	ENSP00000432273	44 (aa)	-	E9PRI8
ENST00000526390	TXNRD1-212	3808	-	ENSP00000435123	543 (aa)	-	Q16881
ENST00000526950	TXNRD1-215	1847	-	ENSP00000432812	568 (aa)	-	A0A182DWI3
ENST00000529546	TXNRD1-219	2018	-	ENSP00000434919	461 (aa)	-	Q16881
ENST00000503506	TXNRD1-205	3930	-	ENSP00000421934	499 (aa)	-	Q16881
ENST00000397736	TXNRD1-203	3832	-	ENSP00000380844	460 (aa)	-	E2QRB9
ENST00000525265	TXNRD1-207	572	-	-	- (aa)	-	-
ENST00000528079	TXNRD1-218	629	-	ENSP00000433732	96 (aa)	-	E9PJU2
ENST00000526580	TXNRD1-213	400	-	ENSP00000433887	103 (aa)	-	A0A0B4J225

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa00450	Selenocompound metabolism	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05225	Hepatocellular carcinoma	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000198431	Pulse Wave Analysis	4.523e-005	-
ENSG00000198431	Blood Glucose	4.7130000E-005	-
ENSG00000198431	Selenium	1E-6	25343990

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198431	rs7975161	12	104251627	T	Toenail selenium levels	25343990	[0.013-0.033] unit decrease	0.023	EFO_0006331
ENSG00000198431	rs7969894	12	104234698	G	Stem cell growth factor beta levels	27989323	[0.28-0.52] SD units decrease	0.4004	EFO_0008292

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198431's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0001707	mesoderm formation	-	IEA	Process
GO:0001887	selenium compound metabolic process	-	TAS	Process
GO:0004791	thioredoxin-disulfide reductase activity	21873635.	IBA	Function
GO:0005515	protein binding	15199063.19820694.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007165	signal transduction	8921404.	NAS	Process
GO:0008283	cell proliferation	-	IEA	Process
GO:0009055	electron transfer activity	-	IEA	Function
GO:0015035	protein disulfide oxidoreductase activity	-	IEA	Function
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0022900	electron transport chain	-	IEA	Process
GO:0034599	cellular response to oxidative stress	-	TAS	Process
GO:0045454	cell redox homeostasis	21873635.	IBA	Process
GO:0050660	flavin adenine dinucleotide binding	-	IEA	Function
GO:0070062	extracellular exosome	18570454.	HDA	Component
GO:0098869	cellular oxidant detoxification	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.