EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19020731Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.Oncol Rep2008 DecWang Y-
15183196Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins.Free Radic Biol Med2004 Jul 1Furman C-
24583460Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.Free Radic Biol Med2014 MayDuan Ddoi: 10.1016/j.freeradbiomed.2014.02.016
21206984Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.Oncol Rep2011 MarIwasawa Sdoi: 10.3892/or.2010.1131
20584310Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.Breast Cancer Res2010Cadenas Cdoi: 10.1186/bcr2599
20920480Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction.Biochem Pharmacol2011 Jan 15Poerschke RLdoi: 10.1016/j.bcp.2010.09.024
24407164Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.Free Radic Biol Med2014 AprDuan Ddoi: 10.1016/j.freeradbiomed.2013.12.027
27381867Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase.Biochem Biophys Res Commun2016 Sep 9Jayakumar Sdoi: 10.1016/j.bbrc.2016.06.144
28218611Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.Gen Physiol Biophys2017 AprHwang-Bo Hdoi: 10.4149/gpb_2016043
26919094Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.Oncotarget2016 Mar 29Chen Wdoi: 10.18632/oncotarget.7565.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr12104287381Intronnovel0.24
BLCAchr12104327661Missense_MutationnovelS511F0.45
BLCAchr12104331600Missense_MutationNAE537K0.25
BLCAchr121043484973'UTRnovel0.16
BLCAchr12104325385Nonsense_MutationNAQ422*0.21
BLCAchr12104321286Missense_MutationnovelI395M0.24
BLCAchr12104215815Missense_MutationNAE5K0.67
BRCAchr12104287070Intronnovel0.2
BRCAchr12104289013Missense_Mutationrs773469710K129N0.15
BRCAchr12104319557Missense_MutationNAP321S0.44
BRCAchr12104287130Intronnovel0.1
CESCchr12104288907IntronNA0.38
CESCchr12104251667Missense_Mutationrs769989720R78C0.43
CESCchr12104339142Missense_Mutationrs369684801R584C0.42
CESCchr12104251610Missense_MutationnovelL59F0.42
CESCchr12104287292Intronnovel0.16
CESCchr12104325429Splice_Regionrs771896901T436T0.24
CESCchr12104331600Missense_MutationNAE537Q0.07
CESCchr12104334334Splice_SitenovelX582_splice0.36
COADchr12104325401Missense_MutationNAE427V0.18
COADchr12104319056Splice_SiteNAX291_splice0.34
COADchr12104321095Missense_MutationnovelD332Y0.18
COADchr12104319495Missense_MutationNAK300T0.24
COADchr12104321304Silentrs547545865F401F0.19
COADchr12104348411Missense_MutationNAC647Y0.31
COADchr12104287273Intronnovel0.22
COADchr12104319486Missense_MutationNAG297D0.25
COADchr12104258038Missense_MutationnovelS88Y0.1
COADchr12104318982Missense_Mutationrs189358801R267Q0.25
COADchr12104319496Missense_MutationnovelK300N0.1
COADchr12104289022SilentnovelG132G0.17
COADchr12104319552Missense_MutationNAG319D0.21
ESCAchr12104288953SilentnovelG109G0.34
ESCAchr12104315799Missense_MutationnovelN211K0.2
ESCAchr12104348355Splice_RegionnovelV628V0.25
ESCAchr12104289014Missense_MutationnovelI130L0.65
GBMchr12104327638SilentNAL503L0.31
GBMchr12104319582Frame_Shift_DelnovelS329Tfs*360.07
GBMchr12104321196Silentrs201777096D365D0.74
GBMchr12104318931Missense_MutationnovelR250I0.11
GBMchr12104311306Missense_MutationNAR144K0.33
HNSCchr12104288952Missense_MutationnovelG109E0.29
HNSCchr12104311353Missense_MutationnovelS160P0.26
HNSCchr12104339207Silentrs764327204A605A0.22
HNSCchr12104331601Missense_MutationnovelE537G0.15
HNSCchr12104319047Missense_MutationnovelR289W0.11
HNSCchr12104251546SilentnovelG37G0.26
KIRPchr12104325428Missense_Mutationrs144671274T436M0.04
KIRPchr12104287305Intronnovel0.28
KIRPchr12104327672Splice_SitenovelX514_splice0.39
KIRPchr12104287347Intronnovel0.28
LGGchr12104287389Intronnovel0.09
LIHCchr12104288928Splice_Regionnovel0.46
LIHCchr12104251628Missense_MutationNAG65S0.23
LUADchr12104311357Missense_Mutationrs780170129Y161C0.29
LUADchr12104331589Missense_MutationnovelC533Y0.34
LUADchr12104251538Missense_MutationnovelH35N0.25
LUADchr12104251625Missense_MutationNAD64Y0.35
LUSCchr12104319008Frame_Shift_DelnovelV276Mfs*880.53
LUSCchr12104288927Splice_Regionnovel0.16
LUSCchr12104215815Missense_MutationNAE5K0.75
LUSCchr12104288954Missense_MutationnovelT110A0.04
LUSCchr12104287384Intronnovel0.3
LUSCchr12104327668SilentNAV513V0.12
LUSCchr12104287330Intronnovel0.28
LUSCchr12104251561Missense_Mutationrs773611266E42D0.26
LUSCchr12104287418Intronnovel0.09
LUSCchr12104288902Intronnovel0.26
LUSCchr12104315801Frame_Shift_InsnovelC214Lfs*40.68
OVchr12104288971SilentnovelA115A0.13
OVchr12104287413Intronnovel0.05
OVchr12104288923Splice_Regionnovel0.29
OVchr12104288894Intronnovel0.07
OVchr121043486033'UTRnovel0.6
PAADchr12104288947SilentnovelL107L0.16
PCPGchr12104319574SilentnovelY326Y0.21
PRADchr12104331567Missense_MutationnovelT526P0.35
PRADchr12104348353Missense_MutationNAV628L0.37
PRADchr12104315896Missense_MutationnovelV244L0.48
PRADchr12104327655Missense_MutationnovelA509V0.41
READchr12104326381Missense_MutationnovelR448K0.23
READchr12104251667Missense_Mutationrs769989720R78C0.37
READchr12104315890Nonsense_MutationnovelE242*0.06
SARCchr12104288972Missense_MutationnovelA116S0.2
SARCchr12104321126Missense_MutationnovelK342M0.26
SARCchr12104321127SilentnovelK342K0.26
SARCchr12104326386Missense_MutationnovelI450F0.36
SARCchr12104331630Missense_MutationnovelE547K0.08
SKCMchr12104251532Missense_MutationNAD33N0.29
SKCMchr12104311368Missense_MutationNAL165F0.12
SKCMchr12104348398Missense_MutationNAL643F0.26
SKCMchr12104315805SilentnovelG213G0.37
SKCMchr12104287386Intronnovel0.26
SKCMchr12104318981Nonsense_MutationnovelR267*0.21
SKCMchr121043484653'UTRrs7469793280.34
SKCMchr12104288980SilentNAT118T0.32
SKCMchr12104319540Missense_MutationNAP315L0.52
STADchr12104321284Missense_MutationnovelI395F0.11
STADchr12104339153SilentnovelG587G0.17
STADchr12104339275Splice_SiteNAX627_splice0.13
STADchr12104289021Missense_MutationNAG132D0.22
STADchr12104311389Missense_MutationNAS172P0.24
STADchr121043484713'UTRrs3729583940.27
STADchr12104348393Missense_MutationNAS641N0.18
STADchr12104287348Intronnovel0.33
STADchr12104287118Intronnovel0.3
STADchr12104288969Missense_MutationNAA115S0.3
TGCTchr12104315782Missense_Mutationrs370602169G206R0.04
UCECchr12104258038Missense_MutationNAS88F0.26
UCECchr12104339240Missense_MutationnovelD616E0.36
UCECchr12104311334SilentnovelG153G0.23
UCECchr121043484893'UTRnovel0.06
UCECchr12104319511SilentnovelE305E0.35
UCECchr12104325345SilentnovelQ408Q0.36
UCECchr12104326401Missense_Mutationrs201533043V455I0.36
UCECchr12104331630Nonsense_MutationNAE547*0.35
UCECchr12104258148Intronnovel0.37
UCECchr12104215888Missense_MutationnovelR29K0.58
UCECchr12104321155Missense_MutationnovelA352T0.42
UCECchr121043494753'UTRnovel0.47
UCECchr121043486033'UTRnovel0.13
UCECchr12104327671Missense_MutationNAK514N0.19
UCECchr12104251544Missense_MutationnovelG37C0.09
UCECchr12104258216Intronnovel0.33
UCECchr12104258026Missense_MutationnovelK84T0.33
UCECchr12104315795Missense_MutationnovelV210A0.39
UCECchr12104310079Intronnovel0.38
UCECchr12104251628Missense_MutationNAG65S0.35
UCECchr12104339166Missense_Mutationrs557961762G592S0.43
UCECchr12104224893Intronnovel0.35
UCECchr12104331614SilentnovelV541V0.3
UCECchr12104334295Missense_MutationnovelK570R0.39
UCECchr12104311356Missense_MutationnovelY161H0.26
UCECchr12104331587SilentnovelA532A0.46
UCECchr12104309850Intronnovel0.36
UCECchr121043496413'UTRnovel0.27
UCECchr121043484393'UTRnovel0.14
UCECchr121043486033'UTRnovel0.67
UCECchr12104258024Missense_MutationnovelK83N0.44
UCECchr12104287424Intronnovel0.13
UCECchr12104318982Missense_Mutationrs189358801R267Q0.35
UCECchr12104326412Missense_MutationnovelK458N0.14
UCECchr12104315867Missense_MutationNAR234Q0.34
UCECchr12104331600Missense_MutationNAE537Q0.15
UCECchr12104287403Intronnovel0.43
UCECchr12104251553SilentNAL40L0.31
UCECchr12104311369Missense_MutationnovelL165R0.14
UCECchr12104321155Missense_MutationnovelA352T0.1
UCECchr12104251602Missense_MutationNAR56I0.15
UCECchr12104319486Missense_MutationNAG297D0.35
UCECchr12104348411Missense_MutationNAC647Y0.32
UCECchr12104319491Nonsense_MutationNAE299*0.36
UCECchr12104251551Missense_MutationnovelT39N0.3
UCECchr12104319052Missense_MutationnovelI290M0.06
UCECchr12104311306Missense_Mutationrs368264904R144I0.21
UCECchr12104319506Missense_MutationnovelA304T0.1
UCECchr12104321283SilentnovelG394G0.38
UCECchr12104258135Intronnovel0.36
UCECchr12104334278Silentrs562593393P564P0.5
UCECchr12104319525Missense_MutationNAA310V0.22
UCECchr12104321249Missense_MutationNAA383V0.12
UCECchr12104319543Missense_Mutationrs377062126R316H0.28
UCECchr12104287191Intronnovel0.46

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.03330.20414
CHOLDEL0.22220.067545
HNSCDEL0.06130.22646
LUADDEL0.14920.0059643
LUSCDEL0.09380.038823
PAADDEL0.18480.0030251
PRADAMP0.05890.016187
READDEL0.1030.064633
SKCMDEL0.19890.00079981

Survival Analysis
CancerP-value Q-value
ACC0.03

Kaplan-Meier Survival Analysis

HNSC0.021

Kaplan-Meier Survival Analysis

BRCA0.024

Kaplan-Meier Survival Analysis

KIRP0.00052

Kaplan-Meier Survival Analysis

BLCA0.045

Kaplan-Meier Survival Analysis

LAML0.019

Kaplan-Meier Survival Analysis

KICH0.035

Kaplan-Meier Survival Analysis

UCEC0.041

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

CHOL0.0067

Kaplan-Meier Survival Analysis

THCA0.0049

Kaplan-Meier Survival Analysis

LUAD0.025

Kaplan-Meier Survival Analysis

UVM0.0057

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000198431 (Gene tree)
Gene ID
7296
Gene Symbol
TXNRD1
Alias
TXNR|GRIM-12|Trxr1
Full Name
thioredoxin reductase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
134,529 bases
Position
chr12:104,215,779-104,350,307
Accession
12437
RBP type
non-canonical RBP
Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000531689TXNRD1-222554-ENSP0000043350772 (aa)-E9PKI4
ENST00000524698TXNRD1-2061933-ENSP00000433425499 (aa)-Q16881
ENST00000429002TXNRD1-2043855-ENSP00000412045648 (aa)-A0A087WSY9
ENST00000527335TXNRD1-216786-ENSP00000433599175 (aa)-E9PKD3
ENST00000526006TXNRD1-209502--- (aa)--
ENST00000526207TXNRD1-210551--- (aa)--
ENST00000354940TXNRD1-2014082-ENSP00000347020498 (aa)-F8W809
ENST00000525566TXNRD1-2083836-ENSP00000434516649 (aa)-Q16881
ENST00000529784TXNRD1-221607-ENSP0000043622953 (aa)-E9PQI3
ENST00000388854TXNRD1-2024277-ENSP00000373506548 (aa)-A0A087WSW9
ENST00000526266TXNRD1-211577-ENSP0000043129470 (aa)-E9PLT3
ENST00000534282TXNRD1-224488--- (aa)--
ENST00000527688TXNRD1-2173858-ENSP00000433935482 (aa)-E9PIR7
ENST00000526691TXNRD1-2143974-ENSP00000435929551 (aa)-Q16881
ENST00000531691TXNRD1-223728-ENSP00000431925139 (aa)-E9PIZ5
ENST00000529751TXNRD1-220557-ENSP0000043227344 (aa)-E9PRI8
ENST00000526390TXNRD1-2123808-ENSP00000435123543 (aa)-Q16881
ENST00000526950TXNRD1-2151847-ENSP00000432812568 (aa)-A0A182DWI3
ENST00000529546TXNRD1-2192018-ENSP00000434919461 (aa)-Q16881
ENST00000503506TXNRD1-2053930-ENSP00000421934499 (aa)-Q16881
ENST00000397736TXNRD1-2033832-ENSP00000380844460 (aa)-E2QRB9
ENST00000525265TXNRD1-207572--- (aa)--
ENST00000528079TXNRD1-218629-ENSP0000043373296 (aa)-E9PJU2
ENST00000526580TXNRD1-213400-ENSP00000433887103 (aa)-A0A0B4J225
Gene Model
Click here to download ENSG00000198431's gene model file
Pathways
Pathway IDPathway NameSource
hsa00450Selenocompound metabolismKEGG
hsa05200Pathways in cancerKEGG
hsa05225Hepatocellular carcinomaKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000198431Pulse Wave Analysis4.523e-005-
ENSG00000198431Blood Glucose4.7130000E-005-
ENSG00000198431Selenium1E-625343990
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000198431rs797516112104251627TToenail selenium levels25343990[0.013-0.033] unit decrease0.023EFO_0006331
ENSG00000198431rs796989412104234698GStem cell growth factor beta levels27989323[0.28-0.52] SD units decrease0.4004EFO_0008292
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198431's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001650fibrillar center-IDAComponent
GO:0001707mesoderm formation-IEAProcess
GO:0001887selenium compound metabolic process-TASProcess
GO:0004791thioredoxin-disulfide reductase activity21873635.IBAFunction
GO:0005515protein binding15199063.19820694.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0007165signal transduction8921404.NASProcess
GO:0008283cell proliferation-IEAProcess
GO:0009055electron transfer activity-IEAFunction
GO:0015035protein disulfide oxidoreductase activity-IEAFunction
GO:0015949nucleobase-containing small molecule interconversion-TASProcess
GO:0019216regulation of lipid metabolic process-TASProcess
GO:0022900electron transport chain-IEAProcess
GO:0034599cellular response to oxidative stress-TASProcess
GO:0045454cell redox homeostasis21873635.IBAProcess
GO:0050660flavin adenine dinucleotide binding-IEAFunction
GO:0070062extracellular exosome18570454.HDAComponent
GO:0098869cellular oxidant detoxification-IEAProcess
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