EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19521958	Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis.	Int J Cancer	2010 Jan 1	Lan L	doi: 10.1002/ijc.24641.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	52397353	Missense_Mutation	novel	K389N	0.38
BLCA	chr15	52416224	Missense_Mutation	novel	R178Q	0.26
BLCA	chr15	52340354	Missense_Mutation	NA	E1361K	0.13
BLCA	chr15	52428497	Missense_Mutation	novel	E71K	0.3
BLCA	chr15	52353628	Missense_Mutation	NA	E1200K	0.08
BLCA	chr15	52346361	Missense_Mutation	novel	R1320I	0.27
BLCA	chr15	52340354	Missense_Mutation	NA	E1361K	0.22
BLCA	chr15	52375421	Silent	novel	I820I	0.42
BLCA	chr15	52407395	Silent	novel	N281N	0.16
BLCA	chr15	52376434	Missense_Mutation	NA	R778Q	0.29
BLCA	chr15	52416267	Missense_Mutation	novel	E164Q	0.2
BLCA	chr15	52317108	Frame_Shift_Ins	novel	*K1758Nfs5**	0.05
BLCA	chr15	52364698	Silent	novel	T1055T	0.44
BLCA	chr15	52321363	Missense_Mutation	novel	M1624I	0.49
BLCA	chr15	52370285	Missense_Mutation	rs373825708	R984W	0.86
BLCA	chr15	52410362	Missense_Mutation	NA	L243F	0.33
BRCA	chr15	52375447	Silent	NA	L812L	0.14
BRCA	chr15	52313634	3'UTR	novel		0.12
BRCA	chr15	52319097	Missense_Mutation	novel	K1708E	0.1
BRCA	chr15	52351465	Nonsense_Mutation	NA	S1213*	0.23
BRCA	chr15	52319248	Silent	novel	G1657G	0.42
BRCA	chr15	52367103	Missense_Mutation	NA	E1030K	0.39
BRCA	chr15	52370240	Silent	NA	L999L	0.14
BRCA	chr15	52353897	Nonsense_Mutation	NA	E1181*	0.35
BRCA	chr15	52353648	Missense_Mutation	NA	R1193T	0.19
BRCA	chr15	52343175	Nonsense_Mutation	NA	E1328*	0.12
BRCA	chr15	52360030	Missense_Mutation	rs770697352	E1121K	0.3
BRCA	chr15	52327897	Silent	NA	R1530R	0.24
BRCA	chr15	52370195	Missense_Mutation	NA	D1014H	0.52
BRCA	chr15	52375443	Missense_Mutation	rs561485938	R813H	0.25
BRCA	chr15	52376530	In_Frame_Ins	novel	T746delinsKKCSTSP	0.04
BRCA	chr15	52376532	Frame_Shift_Ins	novel	*T746Nfs25**	0.02
BRCA	chr15	52353964	Silent	NA	L1158L	0.28
CESC	chr15	52353628	Missense_Mutation	NA	E1200K	0.24
CESC	chr15	52389291	Missense_Mutation	novel	E539K	0.32
CESC	chr15	52416155	Missense_Mutation	novel	P201R	0.21
CESC	chr15	52372132	Missense_Mutation	NA	D937H	0.11
CESC	chr15	52337836	Intron	NA		0.44
CESC	chr15	52405361	Nonsense_Mutation	NA	R327*	0.22
CESC	chr15	52379639	Missense_Mutation	NA	E732K	0.3
CESC	chr15	52328004	Missense_Mutation	novel	L1495M	0.37
CESC	chr15	52360068	Missense_Mutation	novel	P1108H	0.11
CESC	chr15	52364586	Missense_Mutation	NA	D1093N	0.26
CESC	chr15	52343170	Silent	novel	L1329L	0.22
CESC	chr15	52313411	3'UTR	novel		0.37
COAD	chr15	52387854	Missense_Mutation	NA	Q576R	0.22
COAD	chr15	52372305	Missense_Mutation	rs569010771	R879H	0.3
COAD	chr15	52389308	Missense_Mutation	NA	N533S	0.45
COAD	chr15	52321491	Missense_Mutation	NA	T1582A	0.2
COAD	chr15	52375335	Missense_Mutation	rs754654495	R849Q	0.29
COAD	chr15	52353906	Missense_Mutation	rs767451086	R1178C	0.16
COAD	chr15	52367056	Silent	NA	I1045I	0.21
COAD	chr15	52376399	Missense_Mutation	NA	R790W	0.22
COAD	chr15	52383159	Missense_Mutation	novel	E648D	0.08
COAD	chr15	52376533	Missense_Mutation	novel	K745M	0.39
COAD	chr15	52396367	Silent	novel	E450E	0.38
COAD	chr15	52340332	Missense_Mutation	rs753717165	R1368H	0.13
COAD	chr15	52379889	Missense_Mutation	novel	V678M	0.05
COAD	chr15	52317191	Missense_Mutation	rs369584772	R1731C	0.38
COAD	chr15	52375368	Missense_Mutation	novel	R838Q	0.35
COAD	chr15	52351480	Missense_Mutation	rs778992454	R1208H	0.39
COAD	chr15	52428521	Nonsense_Mutation	NA	R63*	0.43
COAD	chr15	52375380	Missense_Mutation	NA	Y834F	0.34
COAD	chr15	52327902	Missense_Mutation	NA	V1529L	0.43
COAD	chr15	52372321	Missense_Mutation	NA	R874W	0.22
COAD	chr15	52389302	Missense_Mutation	novel	C535S	0.31
COAD	chr15	52370265	Missense_Mutation	NA	E990D	0.38
COAD	chr15	52410336	Silent	NA	F251F	0.46
COAD	chr15	52405303	Missense_Mutation	NA	D346G	0.2
COAD	chr15	52397258	Missense_Mutation	NA	Q421R	0.08
COAD	chr15	52364695	Missense_Mutation	novel	M1056I	0.06
COAD	chr15	52384234	Missense_Mutation	rs751663129	R614Q	0.29
COAD	chr15	52321366	Silent	novel	P1623P	0.36
COAD	chr15	52313663	3'UTR	novel		0.18
COAD	chr15	52317076	Missense_Mutation	NA	S1769Y	0.21
COAD	chr15	52376523	Silent	novel	I748I	0.11
COAD	chr15	52383120	Silent	novel	I661I	0.12
COAD	chr15	52396371	Missense_Mutation	NA	F449C	0.13
COAD	chr15	52397246	Missense_Mutation	novel	S425Y	0.24
COAD	chr15	52319095	Silent	NA	K1708K	0.3
COAD	chr15	52351291	Missense_Mutation	NA	S1271Y	0.26
COAD	chr15	52405361	Nonsense_Mutation	NA	R327*	0.44
COAD	chr15	52336477	Frame_Shift_Ins	novel	*I1440Nfs19**	0.44
COAD	chr15	52317074	Missense_Mutation	novel	M1770L	0.57
COAD	chr15	52353988	Silent	novel	L1150L	0.08
COAD	chr15	52383100	Missense_Mutation	novel	F668S	0.52
COAD	chr15	52375377	Missense_Mutation	novel	K835R	0.3
COAD	chr15	52389297	Missense_Mutation	NA	L537I	0.22
COAD	chr15	52410392	Nonsense_Mutation	NA	R233*	0.21
COAD	chr15	52384234	Missense_Mutation	rs751663129	R614Q	0.24
ESCA	chr15	52379840	Missense_Mutation	novel	A694V	0.16
ESCA	chr15	52384255	Missense_Mutation	novel	S607L	0.21
GBM	chr15	52372345	Missense_Mutation	novel	A866T	0.42
GBM	chr15	52425917	Missense_Mutation	novel	I123S	0.43
GBM	chr15	52405300	Missense_Mutation	novel	S347N	0.13
GBM	chr15	52313626	3'UTR	novel		0.13
GBM	chr15	52397212	Silent	novel	L436L	0.05
GBM	chr15	52319187	Missense_Mutation	novel	H1678D	0.06
GBM	chr15	52319324	Missense_Mutation	novel	H1632L	0.54
HNSC	chr15	52384309	Missense_Mutation	novel	P589L	0.56
HNSC	chr15	52433258	Missense_Mutation	novel	E19Q	0.28
HNSC	chr15	52317209	Nonsense_Mutation	novel	Q1725*	0.33
HNSC	chr15	52379834	Missense_Mutation	novel	G696D	0.12
HNSC	chr15	52392040	Missense_Mutation	novel	M478V	0.16
HNSC	chr15	52405360	Missense_Mutation	rs548669169	R327Q	0.24
HNSC	chr15	52372217	Silent	novel	L908L	0.34
HNSC	chr15	52397330	Missense_Mutation	novel	T397K	0.23
HNSC	chr15	52405374	Missense_Mutation	novel	Q322H	0.26
HNSC	chr15	52327860	Missense_Mutation	novel	V1543L	0.21
HNSC	chr15	52367068	Silent	novel	L1041L	0.19
HNSC	chr15	52364585	Missense_Mutation	novel	D1093V	0.32
HNSC	chr15	52379851	Silent	novel	I690I	0.21
HNSC	chr15	52313839	Nonsense_Mutation	novel	R1809*	0.31
HNSC	chr15	52327920	Silent	novel	L1523L	0.12
HNSC	chr15	52317191	Missense_Mutation	novel	R1731G	0.12
HNSC	chr15	52379904	Missense_Mutation	NA	D673H	0.26
HNSC	chr15	52433232	Silent	novel	L27L	0.12
HNSC	chr15	52319099	Missense_Mutation	rs758007236	R1707Q	0.08
HNSC	chr15	52376497	Missense_Mutation	novel	Y757F	0.23
HNSC	chr15	52340332	Missense_Mutation	rs753717165	R1368L	0.17
KIRC	chr15	52353639	Missense_Mutation	NA	I1196S	0.22
KIRC	chr15	52353994	Silent	NA	V1148V	0.18
KIRC	chr15	52428453	Silent	NA	V85V	0.08
KIRC	chr15	52410382	Missense_Mutation	NA	G236A	0.07
KIRP	chr15	52407329	Silent	novel	K303K	0.33
KIRP	chr15	52323416	Missense_Mutation	novel	S1555C	0.42
KIRP	chr15	52314174	Silent	NA	P1788P	0.35
LAML	chr15	52416177	Missense_Mutation	novel	E194K	0.07
LGG	chr15	52428416	Missense_Mutation	NA	L98V	0.33
LGG	chr15	52330448	Missense_Mutation	NA	R1462Q	0.37
LGG	chr15	52376454	Silent	novel	I771I	0.27
LGG	chr15	52330449	Nonsense_Mutation	NA	R1462*	0.45
LGG	chr15	52313719	Silent	novel	L1849L	0.08
LGG	chr15	52340384	Missense_Mutation	novel	S1351P	0.15
LGG	chr15	52379713	Frame_Shift_Del	novel	*F707Sfs7**	0.41
LIHC	chr15	52343122	Silent	novel	A1345A	0.13
LIHC	chr15	52360080	Missense_Mutation	NA	H1104R	0.26
LIHC	chr15	52330493	Missense_Mutation	NA	Q1447L	0.67
LIHC	chr15	52346433	Frame_Shift_Del	novel	*L1296Wfs7**	0.42
LIHC	chr15	52319271	Missense_Mutation	novel	T1650S	0.37
LUAD	chr15	52364633	Missense_Mutation	novel	R1077K	0.11
LUAD	chr15	52353608	Silent	NA	L1206L	0.05
LUAD	chr15	52319281	Silent	novel	L1646L	0.13
LUAD	chr15	52372319	Silent	NA	R874R	0.36
LUAD	chr15	52353980	Nonsense_Mutation	NA	S1153*	0.2
LUAD	chr15	52379859	Nonsense_Mutation	novel	E688*	0.39
LUAD	chr15	52428433	Missense_Mutation	novel	R92L	0.05
LUAD	chr15	52319301	Missense_Mutation	novel	G1640W	0.12
LUAD	chr15	52397220	Missense_Mutation	novel	G434C	0.37
LUAD	chr15	52370237	Missense_Mutation	novel	E1000K	0.26
LUAD	chr15	52330392	Nonsense_Mutation	NA	K1481*	0.19
LUAD	chr15	52354000	Silent	NA	K1146K	0.17
LUAD	chr15	52397330	Missense_Mutation	rs761247058	T397M	0.24
LUAD	chr15	52317222	Missense_Mutation	novel	R1720S	1
LUAD	chr15	52353884	Missense_Mutation	novel	R1185L	0.32
LUAD	chr15	52408141	Splice_Site	novel	X253_splice	0.07
LUAD	chr15	52372168	Missense_Mutation	NA	M925L	0.28
LUAD	chr15	52343146	Silent	novel	L1337L	0.76
LUAD	chr15	52351267	Missense_Mutation	NA	A1279V	0.15
LUSC	chr15	52360037	Silent	novel	S1118S	0.32
LUSC	chr15	52351325	Missense_Mutation	novel	D1260Y	0.24
LUSC	chr15	52321455	Missense_Mutation	NA	D1594H	0.14
LUSC	chr15	52425907	Silent	NA	A126A	0.33
LUSC	chr15	52367110	Silent	NA	L1027L	0.08
LUSC	chr15	52397211	Missense_Mutation	novel	D437H	0.62
LUSC	chr15	52375404	Missense_Mutation	NA	R826P	0.2
LUSC	chr15	52408114	Silent	NA	I261I	0.3
LUSC	chr15	52327963	Silent	novel	L1508L	0.22
LUSC	chr15	52364617	Silent	rs755587361	L1082L	0.11
LUSC	chr15	52379839	Silent	novel	A694A	0.33
LUSC	chr15	52327928	Missense_Mutation	NA	A1520V	0.2
LUSC	chr15	52367100	Missense_Mutation	NA	N1031H	0.19
LUSC	chr15	52376433	Silent	novel	R778R	0.69
LUSC	chr15	52370283	Silent	novel	R984R	0.42
LUSC	chr15	52428537	Silent	NA	K57K	0.3
LUSC	chr15	52379653	Missense_Mutation	novel	C727F	0.18
LUSC	chr15	52384284	Missense_Mutation	novel	K597N	0.17
MESO	chr15	52351259	Missense_Mutation	novel	P1282T	0.22
OV	chr15	52425959	Missense_Mutation	NA	A109G	0.44
OV	chr15	52425950	Nonsense_Mutation	novel	*P112delinsQMKGLVS**	0.11
OV	chr15	52425951	Frame_Shift_Ins	novel	*P112Vfs35**	0.05
OV	chr15	52397216	Missense_Mutation	novel	V435G	0.11
OV	chr15	52370225	Missense_Mutation	novel	S1004T	0.08
OV	chr15	52353983	Missense_Mutation	novel	M1152R	0.04
OV	chr15	52319077	Missense_Mutation	novel	S1714R	0.1
OV	chr15	52353934	Silent	novel	E1168E	0.08
OV	chr15	52397279	Missense_Mutation	NA	W414S	0.15
OV	chr15	52375301	Splice_Region	novel		0.37
OV	chr15	52319229	Missense_Mutation	novel	I1664F	0.61
OV	chr15	52370306	Missense_Mutation	rs373690028	E977K	0.3
OV	chr15	52319079	Missense_Mutation	novel	S1714R	0.2
OV	chr15	52313776	Missense_Mutation	novel	P1830S	0.18
OV	chr15	52340390	Silent	novel	L1349L	0.48
PAAD	chr15	52351400	Missense_Mutation	novel	P1235S	0.32
PAAD	chr15	52379821	Splice_Site	novel	X700_splice	0.15
PAAD	chr15	52364656	Silent	rs183302379	L1069L	0.09
PCPG	chr15	52353902	Missense_Mutation	novel	K1179T	0.13
PRAD	chr15	52372203	Missense_Mutation	NA	R913H	0.26
PRAD	chr15	52375443	Missense_Mutation	rs561485938	R813H	0.34
PRAD	chr15	52340251	Missense_Mutation	novel	A1395V	0.14
PRAD	chr15	52372342	Missense_Mutation	novel	V867I	0.17
READ	chr15	52313602	3'UTR	novel		0.42
READ	chr15	52428520	Missense_Mutation	rs766669585	R63Q	0.43
READ	chr15	52389246	Missense_Mutation	NA	A554S	0.26
READ	chr15	52370378	Missense_Mutation	NA	L953M	0.43
READ	chr15	52319198	Missense_Mutation	NA	V1674D	0.08
READ	chr15	52330465	Silent	NA	I1456I	0.36
SKCM	chr15	52313661	3'UTR	novel		0.27
SKCM	chr15	52359982	Missense_Mutation	NA	P1137S	0.56
SKCM	chr15	52416275	Missense_Mutation	NA	V161A	0.29
SKCM	chr15	52372308	Missense_Mutation	NA	A878V	0.3
SKCM	chr15	52330476	Missense_Mutation	rs147898420	P1453S	0.22
SKCM	chr15	52353900	Missense_Mutation	novel	E1180K	0.28
SKCM	chr15	52313760	Missense_Mutation	NA	S1835F	0.06
SKCM	chr15	52323393	Nonsense_Mutation	novel	S1559_R1563delins*	0.23
SKCM	chr15	52364579	Missense_Mutation	NA	L1095P	0.36
SKCM	chr15	52372253	Silent	NA	F896F	0.36
SKCM	chr15	52351389	Silent	rs374975383	T1238T	0.3
SKCM	chr15	52389255	Nonsense_Mutation	NA	Q551*	0.19
SKCM	chr15	52428421	Missense_Mutation	NA	S96F	0.19
SKCM	chr15	52330424	Missense_Mutation	novel	E1470G	0.29
SKCM	chr15	52330425	Missense_Mutation	novel	E1470K	0.29
SKCM	chr15	52433260	Missense_Mutation	rs753155018	P18L	0.42
SKCM	chr15	52433261	Missense_Mutation	novel	P18S	0.43
SKCM	chr15	52353885	Missense_Mutation	novel	R1185C	0.27
SKCM	chr15	52353886	Silent	novel	L1184L	0.26
SKCM	chr15	52351262	Nonsense_Mutation	novel	Q1281*	0.41
SKCM	chr15	52379880	Silent	NA	L681L	0.3
SKCM	chr15	52376517	Silent	NA	F750F	0.46
SKCM	chr15	52379899	Silent	NA	E674E	0.24
SKCM	chr15	52389355	Silent	NA	K517K	0.36
SKCM	chr15	52319104	Silent	rs779762270	L1705L	0.07
STAD	chr15	52397333	Missense_Mutation	novel	A396V	0.39
STAD	chr15	52375443	Missense_Mutation	rs561485938	R813L	0.37
STAD	chr15	52410351	Missense_Mutation	novel	K246N	0.11
STAD	chr15	52397235	Missense_Mutation	novel	Q429K	0.34
STAD	chr15	52376431	Missense_Mutation	novel	G779V	0.45
STAD	chr15	52397412	Missense_Mutation	NA	E370K	0.15
STAD	chr15	52397258	Missense_Mutation	NA	Q421R	0.32
STAD	chr15	52370301	Silent	novel	A978A	0.33
STAD	chr15	52376366	Missense_Mutation	rs376727710	R801W	0.4
STAD	chr15	52384197	Silent	novel	Q626Q	0.37
STAD	chr15	52351406	Missense_Mutation	NA	S1233G	0.28
STAD	chr15	52396331	Silent	NA	Q462Q	0.25
STAD	chr15	52387874	Frame_Shift_Del	novel	*K569Rfs5**	0.29
STAD	chr15	52313655	3'UTR	rs770980979		0.43
STAD	chr15	52372317	Missense_Mutation	novel	G875D	0.39
STAD	chr15	52314174	Silent	NA	P1788P	0.31
STAD	chr15	52397321	Missense_Mutation	NA	R400H	0.3
STAD	chr15	52372124	Splice_Region	NA	Q939Q	0.26
STAD	chr15	52433249	Missense_Mutation	NA	W22R	0.15
STAD	chr15	52327861	Frame_Shift_Del	novel	*V1543Yfs2**	0.16
STAD	chr15	52407359	Silent	NA	S293S	0.31
STAD	chr15	52376399	Missense_Mutation	NA	R790W	0.33
STAD	chr15	52330449	Nonsense_Mutation	NA	R1462*	0.13
STAD	chr15	52370257	Missense_Mutation	NA	A993V	0.25
STAD	chr15	52319297	Missense_Mutation	NA	V1641A	0.23
STAD	chr15	52323386	Frame_Shift_Del	novel	*L1565Cfs4**	0.38
STAD	chr15	52379850	Nonsense_Mutation	novel	R691*	0.23
STAD	chr15	52370419	Splice_Site	NA	X940_splice	0.23
STAD	chr15	52376476	Missense_Mutation	NA	D764G	0.1
STAD	chr15	52376452	Missense_Mutation	rs185892206	R772Q	0.15
TGCT	chr15	52379633	Silent	novel	L734L	0.06
TGCT	chr15	52353625	Missense_Mutation	novel	L1201V	0.08
THCA	chr15	52317108	In_Frame_Ins	novel	K1758delinsNIFL	0.1
UCEC	chr15	52389237	Splice_Site	NA	X556_splice	0.33
UCEC	chr15	52313576	3'UTR	novel		0.34
UCEC	chr15	52323360	Nonsense_Mutation	NA	E1574*	0.29
UCEC	chr15	52370192	Nonsense_Mutation	NA	R1015*	0.27
UCEC	chr15	52314204	Splice_Site	novel	X1779_splice	0.47
UCEC	chr15	52351291	Missense_Mutation	NA	S1271Y	0.28
UCEC	chr15	52407366	Missense_Mutation	novel	G291E	0.4
UCEC	chr15	52330364	Missense_Mutation	NA	N1490S	0.29
UCEC	chr15	52370341	Missense_Mutation	rs199883205	R965Q	0.12
UCEC	chr15	52376540	Missense_Mutation	NA	F743L	0.35
UCEC	chr15	52396382	Missense_Mutation	NA	E445D	0.47
UCEC	chr15	52397287	Silent	NA	L411L	0.46
UCEC	chr15	52410370	Missense_Mutation	NA	R240I	0.39
UCEC	chr15	52319185	Silent	novel	H1678H	0.41
UCEC	chr15	52327935	Nonsense_Mutation	NA	R1518*	0.31
UCEC	chr15	52353648	Missense_Mutation	novel	R1193I	0.21
UCEC	chr15	52383165	Silent	novel	L646L	0.1
UCEC	chr15	52407376	Missense_Mutation	novel	T288A	0.42
UCEC	chr15	52327935	Nonsense_Mutation	NA	R1518*	0.41
UCEC	chr15	52313422	3'UTR	novel		0.4
UCEC	chr15	52336478	Frame_Shift_Del	novel	*I1440Lfs4**	0.36
UCEC	chr15	52340343	Silent	rs781406210	A1364A	0.42
UCEC	chr15	52353875	Missense_Mutation	novel	A1188V	0.44
UCEC	chr15	52387833	Missense_Mutation	novel	S583N	0.32
UCEC	chr15	52317063	Silent	novel	A1773A	0.45
UCEC	chr15	52319274	Nonsense_Mutation	NA	R1649*	0.37
UCEC	chr15	52425937	Silent	novel	L116L	0.33
UCEC	chr15	52313415	3'UTR	novel		0.4
UCEC	chr15	52387851	Missense_Mutation	NA	I577S	0.33
UCEC	chr15	52389242	Missense_Mutation	novel	D555G	0.07
UCEC	chr15	52375390	Missense_Mutation	rs200320492	R831C	0.21
UCEC	chr15	52379858	Missense_Mutation	NA	E688G	0.34
UCEC	chr15	52313816	Frame_Shift_Ins	novel	*Q1816Hfs25**	0.04
UCEC	chr15	52330499	Nonsense_Mutation	novel	*V1445delinsEILIL**	0.04
UCEC	chr15	52397463	Missense_Mutation	novel	K353E	0.44
UCEC	chr15	52367055	Missense_Mutation	rs56132571	V1046M	0.4
UCEC	chr15	52313644	3'UTR	novel		0.08
UCEC	chr15	52313798	Frame_Shift_Ins	novel	*H1823Tfs57**	0.08
UCEC	chr15	52313800	Frame_Shift_Ins	novel	*K1822Efs58**	0.06
UCEC	chr15	52351291	Missense_Mutation	NA	S1271Y	0.21
UCEC	chr15	52376366	Missense_Mutation	rs376727710	R801W	0.16
UCEC	chr15	52396345	Frame_Shift_Ins	novel	*N458Gfs30**	0.07
UCEC	chr15	52405300	Missense_Mutation	novel	S347N	0.1
UCEC	chr15	52410397	Missense_Mutation	NA	R231I	0.27
UCEC	chr15	52416230	Missense_Mutation	NA	A176V	0.33
UCEC	chr15	52428434	Missense_Mutation	NA	R92C	0.31
UCEC	chr15	52375336	Nonsense_Mutation	novel	R849*	0.19
UCEC	chr15	52383099	Missense_Mutation	novel	F668L	0.25
UCEC	chr15	52405312	Missense_Mutation	rs527359862	R343Q	0.36
UCEC	chr15	52313618	3'UTR	novel		0.43
UCEC	chr15	52313235	3'UTR	novel		0.56
UCEC	chr15	52313571	3'UTR	novel		0.4
UCEC	chr15	52372278	Missense_Mutation	novel	A888V	0.38
UCEC	chr15	52416224	Missense_Mutation	novel	R178Q	0.49
UCEC	chr15	52308728	3'UTR	novel		0.09
UCEC	chr15	52313376	3'UTR	novel		0.25
UCEC	chr15	52340344	Missense_Mutation	novel	A1364V	0.44
UCEC	chr15	52410366	Silent	novel	T241T	0.17
UCEC	chr15	52416293	Missense_Mutation	novel	R155Q	0.48
UCEC	chr15	52313462	3'UTR	novel		0.36
UCEC	chr15	52319292	Missense_Mutation	novel	P1643S	0.26
UCEC	chr15	52389353	Missense_Mutation	novel	G518V	0.26
UCEC	chr15	52376408	Missense_Mutation	novel	L787I	0.16
UCEC	chr15	52312830	3'UTR	novel		0.4
UCEC	chr15	52384249	Missense_Mutation	rs781079093	R609H	0.38
UCEC	chr15	52348828	Splice_Site	NA	X1284_splice	0.34
UCEC	chr15	52313007	3'UTR	novel		0.38
UCEC	chr15	52319200	Silent	rs768731860	S1673S	0.62
UCEC	chr15	52370342	Nonsense_Mutation	NA	R965*	0.22
UCEC	chr15	52313636	3'UTR	novel		0.46
UCEC	chr15	52376486	Missense_Mutation	novel	L761V	0.43
UCEC	chr15	52405365	Missense_Mutation	NA	I325M	0.29
UCEC	chr15	52323421	Silent	rs754004948	T1553T	0.44
UCEC	chr15	52351427	Missense_Mutation	rs766026322	R1226C	0.52
UCEC	chr15	52353972	Missense_Mutation	novel	L1156I	0.5
UCEC	chr15	52384250	Missense_Mutation	rs192993048	R609C	0.38
UCEC	chr15	52317076	Missense_Mutation	NA	S1769Y	0.52
UCEC	chr15	52327858	Silent	novel	V1543V	0.43
UCEC	chr15	52372184	Missense_Mutation	novel	K919N	0.17
UCEC	chr15	52408111	Missense_Mutation	novel	F262L	0.58
UCEC	chr15	52396358	Silent	NA	C453C	0.47
UCEC	chr15	52405292	Missense_Mutation	novel	I350V	0.62
UCEC	chr15	52364604	Missense_Mutation	rs766723050	R1087C	0.26
UCEC	chr15	52313104	3'UTR	novel		0.11
UCEC	chr15	52313567	3'UTR	novel		0.27
UCEC	chr15	52353621	Missense_Mutation	novel	E1202G	0.14
UCEC	chr15	52370257	Missense_Mutation	NA	A993V	0.32
UCEC	chr15	52379838	Missense_Mutation	novel	A695T	0.35
UCEC	chr15	52313211	3'UTR	novel		0.13
UCEC	chr15	52367097	Missense_Mutation	rs754856360	T1032A	0.2
UCEC	chr15	52425931	Missense_Mutation	rs747516586	I118M	0.23
UCEC	chr15	52323384	Missense_Mutation	novel	H1566Y	0.44
UCEC	chr15	52314148	Missense_Mutation	novel	S1797Y	0.57
UCEC	chr15	52336522	Missense_Mutation	rs201575346	T1425M	0.33
UCEC	chr15	52364690	Missense_Mutation	novel	K1058T	0.38
UCEC	chr15	52397330	Missense_Mutation	rs761247058	T397M	0.4
UCEC	chr15	52428474	Silent	novel	S78S	0.16
UCEC	chr15	52379894	Missense_Mutation	novel	R676M	0.32
UCEC	chr15	52308779	3'UTR	novel		0.31
UCEC	chr15	52311859	3'UTR	novel		0.5
UCEC	chr15	52351427	Missense_Mutation	rs766026322	R1226C	0.31
UCEC	chr15	52397233	Silent	novel	Q429Q	0.34
UCEC	chr15	52340312	Missense_Mutation	NA	K1375E	0.12
UCEC	chr15	52387858	Nonsense_Mutation	novel	E575*	0.06
UCEC	chr15	52425917	Missense_Mutation	NA	I123T	0.2
UCEC	chr15	52408064	Missense_Mutation	NA	R278P	0.39
UCEC	chr15	52311767	3'UTR	novel		0.27
UCEC	chr15	52319149	Missense_Mutation	novel	K1690N	0.11
UCEC	chr15	52336516	Missense_Mutation	rs368488059	R1427H	0.13
UCEC	chr15	52337835	Intron	rs751051982		0.28
UCEC	chr15	52397295	Missense_Mutation	NA	A409T	0.18
UCEC	chr15	52321366	Silent	novel	P1623P	0.31
UCEC	chr15	52348819	Missense_Mutation	rs753550026	K1286M	0.55
UCEC	chr15	52379633	Silent	novel	L734L	0.59
UCEC	chr15	52319329	Silent	novel	L1630L	0.07
UCEC	chr15	52319330	Missense_Mutation	novel	L1630Q	0.07
UCEC	chr15	52313392	3'UTR	novel		0.5
UCEC	chr15	52337870	Intron	novel		0.39
UCEC	chr15	52367056	Silent	NA	I1045I	0.5
UCEC	chr15	52387843	Missense_Mutation	NA	L580I	0.44
UCEC	chr15	52408064	Missense_Mutation	NA	R278Q	0.46
UCEC	chr15	52425954	Missense_Mutation	NA	N111H	0.46
UCEC	chr15	52383128	Missense_Mutation	rs762594836	R659C	0.42
UCEC	chr15	52387888	Missense_Mutation	NA	L565I	0.29
UCEC	chr15	52389281	Missense_Mutation	rs769248373	R542H	0.33
UCEC	chr15	52351335	Silent	rs373420132	S1256S	0.28
UCEC	chr15	52392057	Missense_Mutation	novel	L472S	0.29
UCEC	chr15	52323368	Missense_Mutation	novel	Y1571C	0.27
UCEC	chr15	52330470	Nonsense_Mutation	novel	Q1455*	0.23
UCEC	chr15	52370234	Nonsense_Mutation	novel	Q1001*	0.24
UCEC	chr15	52372204	Missense_Mutation	rs779455603	R913C	0.45
UCEC	chr15	52376366	Missense_Mutation	rs376727710	R801W	0.42
UCEC	chr15	52392018	Missense_Mutation	novel	T485I	0.22
UCEC	chr15	52397388	Missense_Mutation	rs575067651	R378W	0.24
UCEC	chr15	52405310	Missense_Mutation	novel	D344N	0.3
UCEC	chr15	52428405	Silent	rs770112853	T101T	0.17
UCEC	chr15	52340296	Missense_Mutation	rs759219111	R1380Q	0.4
UCEC	chr15	52410392	Nonsense_Mutation	NA	R233*	0.5
UCEC	chr15	52428405	Silent	rs770112853	T101T	0.34
UCEC	chr15	52313798	Nonsense_Mutation	novel	*H1823Dfs4**	0.07
UCEC	chr15	52379710	Missense_Mutation	novel	S708N	0.32
UCEC	chr15	52323368	Missense_Mutation	novel	Y1571C	0.42
UCEC	chr15	52428436	Missense_Mutation	novel	V91A	0.5
UCEC	chr15	52336478	Frame_Shift_Del	novel	*I1440Lfs4**	0.14
UCEC	chr15	52379839	Silent	rs193027836	A694A	0.27
UCEC	chr15	52313608	3'UTR	novel		0.38
UCEC	chr15	52370285	Missense_Mutation	rs373825708	R984W	0.43
UCEC	chr15	52311962	3'UTR	novel		0.37
UCEC	chr15	52351481	Missense_Mutation	rs746171056	R1208C	0.36
UCS	chr15	52425868	Silent	novel	I139I	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2	0.079424
CESC	DEL	0.1864	0.00049652
KICH	AMP	0.2576	0.21756
KIRP	DEL	0.1007	0.2062
PAAD	DEL	0.1141	0.13216
READ	DEL	0.4364	0.025797

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0052	Kaplan-Meier Survival Analysis
STAD	0.0017	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
PAAD	0.019	Kaplan-Meier Survival Analysis
PCPG	0.036	Kaplan-Meier Survival Analysis
BLCA	0.0036	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
THCA	0.043	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000197535 (Gene tree)
Gene ID: 4644
Gene Symbol: MYO5A
Alias: MYO5|GS1|MYR12|MYH12
Full Name: myosin VA
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 221,768 bases
Position: chr15:52,307,283-52,529,050
Accession: 7602
Summary: This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23176491	Roles for myosin Va in RNA transport and turnover.	Biochem Soc Trans	2012 Dec 1	McCaffrey MW	doi: 10.1042/BST20120172.
17141617	Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.	Curr Biol	2006 Dec 5	Yoshimura A	-
24637809	Actin and myosin-dependent localization of mRNA to dendrites.	PLoS One	2014 Mar 17	Balasanyan V	doi: 10.1371/journal.pone.0092349
24272908	Myosin Va associates with mRNA in ribonucleoprotein particles present in myelinated peripheral axons and in the central nervous system.	Dev Neurobiol	2014 Mar	Calliari A	doi: 10.1002/dneu.22155
28566250	Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.	EBioMedicine	2017 Jun	Kobayashi S	doi: 10.1016/j.ebiom.2017.05.012

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000358212	MYO5A-202	12220	-	ENSP00000350945	1855 (aa)	-	F8W6H6
ENST00000399229	MYO5A-204	1758	-	ENSP00000382175	585 (aa)	-	E7ERV5
ENST00000556196	MYO5A-210	3008	-	ENSP00000451178	47 (aa)	-	G3V3C9
ENST00000568914	MYO5A-212	693	-	ENSP00000458016	231 (aa)	-	O95317
ENST00000613858	MYO5A-213	12139	-	ENSP00000481420	1828 (aa)	-	A0A087WY00
ENST00000399233	MYO5A-206	12220	XM_011521607	ENSP00000382179	1855 (aa)	XP_011519909	F8WE88
ENST00000399231	MYO5A-205	12225	XM_011521606	ENSP00000382177	1855 (aa)	XP_011519908	Q9Y4I1
ENST00000465290	MYO5A-207	583	-	-	- (aa)	-	-
ENST00000469611	MYO5A-208	500	-	-	- (aa)	-	-
ENST00000399228	MYO5A-203	684	-	ENSP00000382174	228 (aa)	-	Q9UES5
ENST00000553916	MYO5A-209	5989	XM_005254397	ENSP00000451109	1853 (aa)	XP_005254454	G3V394
ENST00000356338	MYO5A-201	11971	XM_011521611	ENSP00000348693	1828 (aa)	XP_011519913	Q9Y4I1
ENST00000561810	MYO5A-211	435	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000197535's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000197535	Urinalysis	7.73635665676305E-6	17903292
ENSG00000197535	Hip	2.59134757096585E-7	17903296
ENSG00000197535	Heart Failure	2E-6	23934736

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197535	rs2222656	15	52480826	A	Metabolite levels (Pyroglutamine)	23934736	[0.07-0.17] unit decrease	0.12	EFO_0005408
ENSG00000197535	rs752864	15	52339794	?	Number of common colds	28928442	[0.01-0.026] unit decrease	0.0181	EFO_0008417

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197535's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197535	MYO5A	100	99.487	ENSMUSG00000034593	Myo5a	100	99.487	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000146	microfilament motor activity	10448864.	NAS	Function
GO:0001726	ruffle	9852149.	IDA	Component
GO:0001750	photoreceptor outer segment	-	IEA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	11980908.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	9852149.	IDA	Component
GO:0005764	lysosome	24006491.	IDA	Component
GO:0005769	early endosome	24006491.	IDA	Component
GO:0005770	late endosome	24006491.	IDA	Component
GO:0005777	peroxisome	24006491.	IDA	Component
GO:0005783	endoplasmic reticulum	24006491.	IDA	Component
GO:0005790	smooth endoplasmic reticulum	-	IEA	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005829	cytosol	24006491.	IDA	Component
GO:0005882	intermediate filament	-	IEA	Component
GO:0005884	actin filament	24006491.	IDA	Component
GO:0006887	exocytosis	-	IEA	Process
GO:0006892	post-Golgi vesicle-mediated transport	24006491.	IMP	Process
GO:0007268	chemical synaptic transmission	-	IEA	Process
GO:0007601	visual perception	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	24006491.	IDA	Component
GO:0016192	vesicle-mediated transport	-	ISS	Process
GO:0016461	unconventional myosin complex	-	IEA	Component
GO:0017137	Rab GTPase binding	15357836.24006491.	IPI	Function
GO:0030048	actin filament-based movement	10448864.	NAS	Process
GO:0030050	vesicle transport along actin filament	24006491.	IMP	Process
GO:0030073	insulin secretion	-	IEA	Process
GO:0030318	melanocyte differentiation	-	IEA	Process
GO:0030426	growth cone	10391919.	NAS	Component
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	-	IEA	Process
GO:0031982	vesicle	24006491.	IDA	Component
GO:0031987	locomotion involved in locomotory behavior	-	IEA	Process
GO:0032252	secretory granule localization	-	IEA	Process
GO:0032402	melanosome transport	11980908.	NAS	Process
GO:0032433	filopodium tip	24006491.	IDA	Component
GO:0032593	insulin-responsive compartment	-	ISS	Component
GO:0032869	cellular response to insulin stimulus	-	ISS	Process
GO:0035371	microtubule plus-end	-	IEA	Component
GO:0042438	melanin biosynthetic process	-	IEA	Process
GO:0042470	melanosome	11980908.	IDA	Component
GO:0042476	odontogenesis	-	IEA	Process
GO:0042552	myelination	-	IEA	Process
GO:0042641	actomyosin	-	IEA	Component
GO:0042759	long-chain fatty acid biosynthetic process	-	IEA	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0043005	neuron projection	10391919.	NAS	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0048820	hair follicle maturation	-	IEA	Process
GO:0050808	synapse organization	-	IEA	Process
GO:0051015	actin filament binding	-	IEA	Function
GO:0055037	recycling endosome	24006491.	IDA	Component
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0072659	protein localization to plasma membrane	-	ISS	Process
GO:0097718	disordered domain specific binding	-	IEA	Function
GO:0098794	postsynapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099089	establishment of endoplasmic reticulum localization to postsynapse	-	IEA	Process
GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	-	IEA	Process
GO:1903358	regulation of Golgi organization	24006491.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.