EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22525274	ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.	Oncogene	2013 Feb 21	Galeano F	doi: 10.1038/onc.2012.125
28035363	ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.	Int J Oncol	2017 Feb	Chen YB	doi: 10.3892/ijo.2016.3823
25582055	Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.	Genome Biol	2015 Jan 13	Tomaselli S	doi: 10.1186/s13059-014-0575-z.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr21	45221009	Missense_Mutation	rs763929833	G681S	0.24	dsrm
BLCA	chr21	45221008	Silent	NA	H680H	0.08
BLCA	chr21	45225576	3'UTR	novel		0.17
BLCA	chr21	45222069	Missense_Mutation	NA	E700K	0.36	dsrm
BLCA	chr21	45183393	Missense_Mutation	rs760565860	Q427E	0.12	dsrm
BLCA	chr21	45204618	Silent	rs372954828	S583S	0.43
BLCA	chr21	45176394	Silent	rs377458378	P231P	0.21
BRCA	chr21	45185028	Missense_Mutation	NA	T541M	0.13	dsrm
BRCA	chr21	45176118	Silent	rs753361667	L139L	0.47
BRCA	chr21	45175768	Missense_Mutation	novel	D23N	0.05
BRCA	chr21	45134758	Silent	rs367651244	A11A	0.5
CESC	chr21	45176166	Missense_Mutation	novel	M155I	0.12
CESC	chr21	45182692	Nonsense_Mutation	novel	E396*	0.17	dsrm
CESC	chr21	45182693	Frame_Shift_Ins	novel	*E396Dfs3**	0.17	dsrm
CESC	chr21	45220992	Missense_Mutation	rs752123605	R675H	0.39	dsrm
CESC	chr21	45176524	Missense_Mutation	NA	E275Q	0.41
COAD	chr21	45180408	Missense_Mutation	novel	R348C	0.07
COAD	chr21	45182685	Silent	NA	C393C	0.34
COAD	chr21	45220991	Missense_Mutation	rs764962336	R675C	0.29	dsrm
COAD	chr21	45175926	Silent	novel	G75G	0.16
COAD	chr21	45176567	Missense_Mutation	novel	A289V	0.23
COAD	chr21	45176238	Silent	NA	G179G	0.1
COAD	chr21	45225566	3'UTR	novel		0.43
COAD	chr21	45176564	Missense_Mutation	novel	A288V	0.41
COAD	chr21	45224889	3'UTR	novel		0.51
COAD	chr21	45176019	Silent	rs201356458	A106A	0.26
COAD	chr21	45222136	Missense_Mutation	novel	A722V	0.44
COAD	chr21	45183499	Missense_Mutation	NA	P462L	0.28	dsrm
COAD	chr21	45180435	Missense_Mutation	novel	M357V	0.14
COAD	chr21	45222304	3'UTR	novel		0.3
COAD	chr21	45225460	3'UTR	novel		0.39
COAD	chr21	45204677	Missense_Mutation	NA	R603Q	0.31	dsrm
COAD	chr21	45224808	3'UTR	novel		0.14
COAD	chr21	45175927	Missense_Mutation	NA	P76S	0.29
COAD	chr21	45182633	Missense_Mutation	novel	K376T	0.12	dsrm
COAD	chr21	45183472	Missense_Mutation	NA	D453V	0.4	dsrm
COAD	chr21	45221000	Missense_Mutation	novel	R678C	0.63	dsrm
COAD	chr21	45176314	Missense_Mutation	novel	D205N	0.34
COAD	chr21	45176258	Missense_Mutation	rs755455385	A186V	0.48
COAD	chr21	45176336	Missense_Mutation	rs200222908	P212L	0.28
COAD	chr21	45225625	3'UTR	novel		0.37
COAD	chr21	45225449	3'UTR	novel		0.47
COAD	chr21	45176432	Missense_Mutation	rs774995629	R244H	0.27
DLBC	chr21	45176019	Silent	rs201356458	A106A	0.12
GBM	chr21	45182685	Frame_Shift_Del	novel	*H394Mfs4**	0.36	dsrm
GBM	chr21	45180383	Silent	novel	T339T	0.32
GBM	chr21	45225527	3'UTR	novel		0.24
GBM	chr21	45225667	3'UTR	novel		0.38
GBM	chr21	45220954	Silent	novel	G662G	0.4
GBM	chr21	45222082	Missense_Mutation	novel	A704V	0.07	dsrm
HNSC	chr21	45176107	Missense_Mutation	novel	E136K	0.17
HNSC	chr21	45176259	Silent	rs146135960	A186A	0.18
HNSC	chr21	45176128	Missense_Mutation	rs558219105	V143I	0.54
HNSC	chr21	45176409	Silent	NA	P236P	0.34
KIRC	chr21	45222188	Silent	NA	L739L	0.17
KIRP	chr21	45183399	Missense_Mutation	novel	S429A	0.43	dsrm
KIRP	chr21	45176525	Missense_Mutation	novel	E275G	0.09
KIRP	chr21	45176432	Missense_Mutation	rs774995629	R244H	0.4
LAML	chr21	45184930	Silent	novel	A508A	0.09
LAML	chr21	45204583	Missense_Mutation	novel	L572M	0.09	dsrm
LGG	chr21	45204677	Missense_Mutation	NA	R603Q	0.39	dsrm
LIHC	chr21	45185055	Missense_Mutation	NA	R550Q	0.34	dsrm
LUAD	chr21	45180347	Silent	novel	V327V	0.18
LUAD	chr21	45222231	3'UTR	novel		0.15
LUAD	chr21	45175819	Nonsense_Mutation	novel	Q40*	0.07
LUAD	chr21	45183405	Nonsense_Mutation	NA	R431*	0.11	dsrm
LUAD	chr21	45184922	Splice_Site	NA	X506_splice	0.08
LUAD	chr21	45204562	Missense_Mutation	NA	V565L	0.09	dsrm
LUAD	chr21	45176311	Missense_Mutation	NA	G204W	0.34
LUAD	chr21	45182631	Silent	novel	T375T	0.16
LUAD	chr21	45176394	Silent	rs377458378	P231P	0.08
LUAD	chr21	45222110	Silent	rs768328836	A713A	0.16
LUAD	chr21	45222092	Missense_Mutation	NA	E707D	0.31	dsrm
LUAD	chr21	45222067	Missense_Mutation	novel	H699L	0.35	dsrm
LUAD	chr21	45225469	3'UTR	novel		0.1
LUAD	chr21	45204590	Missense_Mutation	novel	S574I	0.37	dsrm
LUAD	chr21	45180341	Silent	rs114027650	D325D	0.56
LUAD	chr21	45171621	5'Flank	novel		0.55
LUAD	chr21	45222025	Missense_Mutation	NA	S685F	0.53	dsrm
LUAD	chr21	45222176	Silent	novel	D735D	0.09
LUAD	chr21	45222161	Missense_Mutation	novel	K730N	0.16
LUAD	chr21	45184946	Missense_Mutation	novel	R514C	0.04	dsrm
LUAD	chr21	45204577	Nonsense_Mutation	NA	G570*	0.58	dsrm
LUSC	chr21	45180341	Silent	rs114027650	D325D	0.18
LUSC	chr21	45220964	Missense_Mutation	novel	R666C	0.17	dsrm
LUSC	chr21	45204624	Silent	novel	I585I	0.2
LUSC	chr21	45220908	Missense_Mutation	novel	S647F	0.3	dsrm
LUSC	chr21	45182705	Missense_Mutation	NA	R400Q	0.17	dsrm
LUSC	chr21	45183412	Missense_Mutation	novel	G433V	0.22	dsrm
LUSC	chr21	45220956	Missense_Mutation	rs775065806	R663H	0.27	dsrm
LUSC	chr21	45204676	Missense_Mutation	novel	R603W	0.18	dsrm
MESO	chr21	45222110	Silent	rs768328836	A713A	0.33
OV	chr21	45176088	Missense_Mutation	novel	K129N	0.04
OV	chr21	45176568	Silent	rs557891335	A289A	0.67
OV	chr21	45184943	Missense_Mutation	novel	N513D	0.11	dsrm
OV	chr21	45176020	Missense_Mutation	novel	P107A	0.11
OV	chr21	45183412	Missense_Mutation	novel	G433V	0.14	dsrm
OV	chr21	45225492	3'UTR	novel		0.14
PAAD	chr21	45176560	Missense_Mutation	rs142476560	R287W	0.27
PAAD	chr21	45180420	Missense_Mutation	novel	L352M	0.07
PRAD	chr21	45225537	3'UTR	novel		0.2
PRAD	chr21	45204708	Silent	novel	L613L	0.7
READ	chr21	45204597	Silent	rs573950124	F576F	0.26
READ	chr21	45182682	Silent	novel	D392D	0.07
READ	chr21	45182663	Missense_Mutation	rs777063481	R386H	0.19	dsrm
READ	chr21	45175768	Missense_Mutation	novel	D23Y	0.13
READ	chr21	45225499	3'UTR	novel		0.33
READ	chr21	45176576	Missense_Mutation	NA	A292D	0.3
SKCM	chr21	45176003	Missense_Mutation	NA	T101N	0.25
SKCM	chr21	45176127	Silent	rs758262178	F142F	0.43
SKCM	chr21	45176336	Missense_Mutation	rs200222908	P212L	0.11
SKCM	chr21	45225752	3'UTR	novel		0.44
SKCM	chr21	45134768	Missense_Mutation	rs780047363	D15N	0.23
SKCM	chr21	45204693	Silent	novel	E608E	0.25
SKCM	chr21	45183435	Nonsense_Mutation	NA	Q441*	0.33	dsrm
SKCM	chr21	45225679	3'UTR	novel		0.43
SKCM	chr21	45225368	3'UTR	novel		0.5
SKCM	chr21	45225564	3'UTR	novel		0.43
SKCM	chr21	45175799	Missense_Mutation	NA	P33L	0.39
SKCM	chr21	45176266	Missense_Mutation	NA	P189S	0.38
SKCM	chr21	45185000	Missense_Mutation	NA	P532S	0.1	dsrm
SKCM	chr21	45175832	Missense_Mutation	NA	G44E	0.13
SKCM	chr21	45220937	Missense_Mutation	novel	G657R	0.46	dsrm
SKCM	chr21	45176385	Silent	novel	F228F	0.58
SKCM	chr21	45176608	Nonsense_Mutation	NA	Q303*	0.16
SKCM	chr21	45204597	Silent	rs573950124	F576F	0.31
SKCM	chr21	45176524	Missense_Mutation	NA	E275K	0.49
SKCM	chr21	45176127	Silent	rs758262178	F142F	0.39
SKCM	chr21	45134818	Missense_Mutation	rs566433955	T8M	0.36
SKCM	chr21	45176392	Missense_Mutation	NA	P231S	0.34
SKCM	chr21	45176461	Missense_Mutation	rs772897635	E254K	0.43
STAD	chr21	45220992	Missense_Mutation	rs752123605	R675H	0.16	dsrm
STAD	chr21	45180439	Splice_Site	novel	X359_splice	0.23
STAD	chr21	45182629	Missense_Mutation	NA	T375A	0.15	dsrm
STAD	chr21	45176581	Missense_Mutation	NA	A294T	0.35
STAD	chr21	45185036	Missense_Mutation	rs757268939	G544R	0.23	dsrm
STAD	chr21	45222143	Frame_Shift_Del	novel	*A726Pfs121**	0.25
STAD	chr21	45176396	Missense_Mutation	NA	S232I	0.35
STAD	chr21	45204563	Missense_Mutation	NA	V565A	0.25	dsrm
STAD	chr21	45204677	Missense_Mutation	NA	R603Q	0.28	dsrm
STAD	chr21	45184947	Missense_Mutation	rs780427333	R514H	0.29	dsrm
STAD	chr21	45176211	Silent	rs574341919	A170A	0.28
STAD	chr21	45182715	Missense_Mutation	NA	L403F	0.18	dsrm
STAD	chr21	45184995	Missense_Mutation	rs770534585	T530M	0.22	dsrm
STAD	chr21	45171662	Silent	NA	D2D	0.09
STAD	chr21	45220992	Missense_Mutation	rs752123605	R675H	0.34	dsrm
STAD	chr21	45175945	Missense_Mutation	NA	A82T	0.32
STAD	chr21	45183485	Silent	NA	F457F	0.36
STAD	chr21	45225642	3'UTR	novel		0.12
THCA	chr21	45171625	5'Flank	NA		0.21
THCA	chr21	45204729	Missense_Mutation	NA	L620F	0.41	dsrm
UCEC	chr21	45134806	Missense_Mutation	rs201160866	P4L	0.42
UCEC	chr21	45225729	3'UTR	novel		0.21
UCEC	chr21	45204597	Silent	rs573950124	F576F	0.34
UCEC	chr21	45225508	3'UTR	novel		0.28
UCEC	chr21	45220959	Missense_Mutation	rs138974538	A664V	0.13	dsrm
UCEC	chr21	45226315	3'UTR	novel		0.3
UCEC	chr21	45176469	Silent	NA	G256G	0.41
UCEC	chr21	45185047	Silent	novel	Q547Q	0.37
UCEC	chr21	45204722	Missense_Mutation	novel	K618R	0.35	dsrm
UCEC	chr21	45222040	In_Frame_Del	novel	I692_K694del	0.15	dsrm
UCEC	chr21	45176660	Missense_Mutation	rs779755980	P320L	0.3
UCEC	chr21	45185054	Missense_Mutation	novel	R550W	0.49	dsrm
UCEC	chr21	45204665	Missense_Mutation	rs779673374	A599V	0.44	dsrm
UCEC	chr21	45176409	Silent	NA	P236P	0.29
UCEC	chr21	45185035	Silent	rs140716415	D543D	0.14
UCEC	chr21	45222036	Missense_Mutation	novel	R689C	0.04	dsrm
UCEC	chr21	45176428	Missense_Mutation	novel	L243M	0.18
UCEC	chr21	45134772	Missense_Mutation	novel	P16H	0.08
UCEC	chr21	45182743	Missense_Mutation	novel	L413F	0.13	dsrm
UCEC	chr21	45225499	3'UTR	novel		0.47
UCEC	chr21	45144758	Intron	novel		0.64
UCEC	chr21	45204632	Missense_Mutation	novel	G588D	0.1	dsrm
UCEC	chr21	45204737	Splice_Site	novel	X623_splice	0.09
UCEC	chr21	45222017	Splice_Site	novel	X683_splice	0.38
UCEC	chr21	45225690	3'UTR	novel		0.32
UCEC	chr21	45134769	Missense_Mutation	novel	D15G	0.28
UCEC	chr21	45182651	Missense_Mutation	novel	Y382C	0.44	dsrm
UCEC	chr21	45220856	Missense_Mutation	rs759280487	R630W	0.41	dsrm
UCEC	chr21	45226415	3'UTR	novel		0.14
UCEC	chr21	45176409	Silent	NA	P236P	0.45
UCEC	chr21	45176588	Frame_Shift_Del	novel	*F297Lfs27**	0.39
UCEC	chr21	45180408	Missense_Mutation	novel	R348C	0.39
UCEC	chr21	45182647	Nonsense_Mutation	novel	E381*	0.38	dsrm
UCEC	chr21	45204597	Silent	rs573950124	F576F	0.46
UCEC	chr21	45226375	3'UTR	rs140433470		0.48
UCEC	chr21	45220927	Silent	rs548829091	N653N	0.37
UCEC	chr21	45225510	3'UTR	novel		0.57
UCEC	chr21	45184946	Missense_Mutation	novel	R514C	0.27	dsrm
UCEC	chr21	45226375	3'UTR	rs140433470		0.29
UCEC	chr21	45171646	5'UTR	novel		0.26
UCEC	chr21	45226500	3'UTR	novel		0.35
UCEC	chr21	45144719	Intron	novel		0.38
UCEC	chr21	45176490	Silent	rs139263374	F263F	0.32
UCEC	chr21	45182616	Missense_Mutation	novel	S370R	0.25	dsrm
UCEC	chr21	45175759	Missense_Mutation	rs142180298	R20C	0.32
UCEC	chr21	45222109	Missense_Mutation	rs748901930	A713V	0.35
UCEC	chr21	45226525	3'UTR	novel		0.4
UCEC	chr21	45204562	Missense_Mutation	NA	V565M	0.1	dsrm
UCEC	chr21	45182705	Missense_Mutation	NA	R400Q	0.36	dsrm
UCEC	chr21	45176490	Silent	rs139263374	F263F	0.42
UCEC	chr21	45183405	Nonsense_Mutation	NA	R431*	0.31	dsrm
UCEC	chr21	45182662	Missense_Mutation	rs771477217	R386C	0.19	dsrm
UCEC	chr21	45226375	3'UTR	rs140433470		0.09
UCEC	chr21	45225592	3'UTR	novel		0.27
UCEC	chr21	45171626	5'Flank	novel		0.6
UCEC	chr21	45220860	Missense_Mutation	novel	Q631R	0.56	dsrm
UCEC	chr21	45176019	Silent	rs201356458	A106A	0.3
UCEC	chr21	45182602	Missense_Mutation	NA	A366T	0.31
UCEC	chr21	45144829	Intron	novel		0.44
UCEC	chr21	45185091	Missense_Mutation	novel	R562H	0.11	dsrm
UCEC	chr21	45226410	3'UTR	novel		0.35
UCEC	chr21	45220933	Silent	rs749436550	T655T	0.22
UCEC	chr21	45220965	Missense_Mutation	novel	R666H	0.43	dsrm
UCEC	chr21	45175869	Missense_Mutation	novel	E56D	0.38
UCEC	chr21	45225764	3'UTR	novel		0.23
UCEC	chr21	45176490	Silent	rs139263374	F263F	0.3
UCEC	chr21	45134757	Missense_Mutation	rs767568497	A11V	0.28
UCEC	chr21	45176147	Missense_Mutation	novel	S149Y	0.17
UCEC	chr21	45176248	Missense_Mutation	novel	P183S	0.47
UCEC	chr21	45220853	Missense_Mutation	rs766126367	A629T	0.24	dsrm
UCEC	chr21	45171625	5'Flank	NA		0.28
UCEC	chr21	45176427	Silent	novel	E242E	0.41
UCEC	chr21	45176612	Missense_Mutation	rs763381312	T304M	0.18
UCEC	chr21	45222140	Silent	novel	G723G	0.28
UCEC	chr21	45225409	3'UTR	novel		0.5
UCEC	chr21	45176311	Missense_Mutation	NA	G204W	0.4
UCEC	chr21	45226305	3'UTR	novel		0.12
UCEC	chr21	45226426	3'UTR	novel		0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
OV	DEL	0.3506	0.022578
THYM	AMP	0.0163	0.24554

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00061	Kaplan-Meier Survival Analysis
STAD	0.024	Kaplan-Meier Survival Analysis
MESO	0.00035	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
COAD	0.0007	Kaplan-Meier Survival Analysis
UCEC	0.02	Kaplan-Meier Survival Analysis
GBM	0.013	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis
OV	0.014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197381 (Gene tree)
Gene ID: 104
Gene Symbol: ADARB1
Alias: ADAR2|DRADA2|ADAR2g|DRABA2|RED1|hRED1|ADAR2a-L1|ADAR2a-L2|ADAR2a-L3|ADAR2a|ADAR2b|ADAR2c|ADAR2d
Full Name: adenosine deaminase RNA specific B1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 152,711 bases
Position: chr21:45,073,853-45,226,563
Accession: 226
RBP type: canonical RBP
Summary: This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000015877	dsrm	PF00035.26	1.9e-27	1	2
ENSP00000015877	dsrm	PF00035.26	1.9e-27	2	2
ENSP00000374513	dsrm	PF00035.26	2.1e-27	1	2
ENSP00000374513	dsrm	PF00035.26	2.1e-27	2	2
ENSP00000486475	dsrm	PF00035.26	2.2e-27	1	2
ENSP00000486475	dsrm	PF00035.26	2.2e-27	2	2
ENSP00000353920	dsrm	PF00035.26	2.3e-27	1	2
ENSP00000353920	dsrm	PF00035.26	2.3e-27	2	2
ENSP00000414600	dsrm	PF00035.26	2.3e-27	1	2
ENSP00000414600	dsrm	PF00035.26	2.3e-27	2	2
ENSP00000387480	dsrm	PF00035.26	1.7e-14	1	1
ENSP00000015877	A_deamin	PF02137.18	5.1e-115	1	1
ENSP00000486475	A_deamin	PF02137.18	5.5e-115	1	1
ENSP00000353920	A_deamin	PF02137.18	8e-114	1	1
ENSP00000414600	A_deamin	PF02137.18	8e-114	1	1
ENSP00000374513	A_deamin	PF02137.18	4e-108	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28268052	Synthesis of native-like crosslinked duplex RNA and study of its properties.	Bioorg Med Chem	2017 Apr 1	Onizuka K	doi: 10.1016/j.bmc.2017.02.034
29419780	Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain.	Genes (Basel)	2018 Feb 8	Filippini A	doi: 10.3390/genes9020079.
14612560	Modulation of RNA editing by functional nucleolar sequestration of ADAR2.	Proc Natl Acad Sci U S A	2003 Nov 25	Sansam CL	-
11479320	Conformational changes that occur during an RNA-editing adenosine deamination reaction.	J Biol Chem	2001 Oct 12	Yi-Brunozzi HY	-
15692744	Resonance assignments of the double-stranded RNA-binding domains of adenosine deaminase acting on RNA 2 (ADAR2).	J Biomol NMR	2005 Jan	Stefl R	-
16672376	Substrate-dependent contribution of double-stranded RNA-binding motifs to ADAR2 function.	Mol Biol Cell	2006 Jul	Xu M	-
27937139	Effects of Aicardi-Goutieres syndrome mutations predicted from ADAR-RNA structures.	RNA Biol	2017 Feb	Fisher AJ	doi: 10.1080/15476286.2016.1267097
28053121	ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.	Nucleic Acids Res	2017 Apr 20	Anantharaman A	doi: 10.1093/nar/gkw1304.
23974981	Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia.	Leukemia	2014 Jan	Allegra D	doi: 10.1038/leu.2013.246
29078406	Site-directed RNA repair of endogenous Mecp2 RNA in neurons.	Proc Natl Acad Sci U S A	2017 Oct 31	Sinnamon JR	doi: 10.1073/pnas.1715320114
9143496	Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3.	Genomics	1997 Apr 15	Mittaz L	-
10376681	Editing of messenger RNA precursors and of tRNAs by adenosine to inosine conversion.	FEBS Lett	1999 Jun 4	Keller W	-
11421361	Substrate recognition by ADAR1 and ADAR2.	RNA	2001 Jun	Wong SK	-
15383678	Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding.	RNA	2004 Oct	Macbeth MR	-
19713932	Editing independent effects of ADARs on the miRNA/siRNA pathways.	EMBO J	2009 Oct 21	Heale BS	doi: 10.1038/emboj.2009.244
22457361	Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment.	J Biol Chem	2012 May 18	Palavicini JP	doi: 10.1074/jbc.M112.366005
20946981	The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.	Cell	2010 Oct 15	Stefl R	doi: 10.1016/j.cell.2010.09.026.
27065196	Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.	Nat Struct Mol Biol	2016 May	Matthews MM	doi: 10.1038/nsmb.3203
25826567	Diverse selective regimes shape genetic diversity at ADAR genes and at their coding targets.	RNA Biol	2015	Forni D	doi: 10.1080/15476286.2015.1017215.
29457714	Selective Recognition of RNA Substrates by ADAR Deaminase Domains.	Biochemistry	2018 Mar 13	Wang Y	doi: 10.1021/acs.biochem.7b01100
24355598	The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients.	Brain Res	2014 Oct 10	Yamashita T	doi: 10.1016/j.brainres.2013.12.011
29944911	Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.	Neurosci Res	2019 Jul	Yamashita T	doi: 10.1016/j.neures.2018.06.004
28167531	Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.	J Biol Chem	2017 Mar 10	Oakes E	doi: 10.1074/jbc.M117.779868
26252972	Effect of mismatch on binding of ADAR2/GluR-2 pre-mRNA complex.	J Mol Model	2015 Sep	Yang J	doi: 10.1007/s00894-015-2760-8
28985428	An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.	Nucleic Acids Res	2017 Oct 13	Qi L	doi: 10.1093/nar/gkx667.
12907730	ADAR2 A-->I editing: site selectivity and editing efficiency are separate events.	Nucleic Acids Res	2003 Aug 15	Kallman AM	-
12810917	Biochemical analysis and scanning force microscopy reveal productive and nonproductive ADAR2 binding to RNA substrates.	RNA	2003 Jul	Klaue Y	-
16257978	A method to find tissue-specific novel sites of selective adenosine deamination.	Nucleic Acids Res	2005 Oct 27	Ohlson J	-
15380184	The binding selectivity of ADAR2's dsRBMs contributes to RNA-editing selectivity.	Chem Biol	2004 Sep	Stephens OM	-
17567573	Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.	J Biol Chem	2007 Aug 3	Singh M	-
29950133	Base-pairing probability in the microRNA stem region affects the binding and editing specificity of human A-to-I editing enzymes ADAR1-p110 and ADAR2.	RNA Biol	2018	Ishiguro S	doi: 10.1080/15476286.2018.1486658

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000611195	ADARB1-213	159	-	ENSP00000478160	52 (aa)	-	Q8TCX7
ENST00000629643	ADARB1-214	4583	XM_006723954	ENSP00000486475	729 (aa)	XP_006724017	P78563
ENST00000437626	ADARB1-205	5032	XM_011529432	ENSP00000414600	741 (aa)	XP_011527734	P78563
ENST00000496664	ADARB1-212	5033	-	ENSP00000435381	741 (aa)	-	P78563
ENST00000449478	ADARB1-206	704	-	ENSP00000387480	141 (aa)	-	A0A0A0MSG8
ENST00000348831	ADARB1-201	6882	XM_017028245	ENSP00000015877	701 (aa)	XP_016883734	P78563
ENST00000460734	ADARB1-207	2523	-	-	- (aa)	-	-
ENST00000389863	ADARB1-204	3563	XM_017028244	ENSP00000374513	714 (aa)	XP_016883733	P78563
ENST00000389861	ADARB1-203	5031	NR_027673	-	- (aa)	-	-
ENST00000360697	ADARB1-202	6604	XM_011529425	ENSP00000353920	741 (aa)	XP_011527727	P78563
ENST00000481022	ADARB1-210	736	-	-	- (aa)	-	-
ENST00000464215	ADARB1-209	389	-	-	- (aa)	-	-
ENST00000631642	ADARB1-215	301	-	-	- (aa)	-	-
ENST00000462214	ADARB1-208	587	-	-	- (aa)	-	-
ENST00000492414	ADARB1-211	4913	-	ENSP00000436367	701 (aa)	-	P78563

Gene Model

Click here to download ENSG00000197381's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197381	Lymphocyte Count	5.8280000E-005	-
ENSG00000197381	Neutrophils	6.1490000E-005	-
ENSG00000197381	Body Mass Index	4E-7	25673413
ENSG00000197381	Respiratory Function Tests	3E-6	17903307
ENSG00000197381	Body Mass Index	2E-7	25673413
ENSG00000197381	Body Mass Index	2E-7	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197381	rs427943	21	45150981	A	Body mass index	28892062	[0.015-0.027] kg/m2 increase	0.021	EFO_0004340
ENSG00000197381	rs9977825	21	45075080	T	Educational attainment (MTAG)	30038396	[0.0062-0.0116] unit decrease	0.0089	EFO_0004784
ENSG00000197381	rs9977825	21	45075080	T	Highest math class taken (MTAG)	30038396	[0.0064-0.013] unit decrease	0.0097	EFO_0004875
ENSG00000197381	rs2838815	21	45209675	?	Pulmonary function	17903307			EFO_0003892
ENSG00000197381	rs2838820	21	45226090	T	Type 2 diabetes	30130595		4.723	EFO_0001360
ENSG00000197381	rs427943	21	45150981	A	Body mass index	30108127	[NR] unit decrease	0.014	EFO_0004340
ENSG00000197381	rs9977825	21	45075080	T	Educational attainment (years of education)	30038396	[0.0063-0.0121] unit decrease	0.0092	EFO_0004784
ENSG00000197381	rs394608	21	45161883	?	Body mass index	30595370			EFO_0004340
ENSG00000197381	rs8130074	21	45078769	C	Educational attainment (years of education)	30038396	[0.0057-0.0115] unit decrease	0.0086	EFO_0004784
ENSG00000197381	rs403694	21	45147710	T	Cigarettes smoked per day (MTAG)	30643251	[0.0078-0.0164] unit increase	0.0121441	EFO_0006525
ENSG00000197381	rs2838771	21	45081661	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0052-0.0097] unit decrease	0.00745667	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197381's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000197381	ADARB1	61	30.193	ENSG00000140955	ADAD2	63	30.570
ENSG00000197381	ADARB1	65	36.701	ENSG00000160710	ADAR	74	42.424
ENSG00000197381	ADARB1	99	53.267	ENSG00000185736	ADARB2	99	53.901

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197381	ADARB1	95	76.471	ENSAPOG00000021275	-	97	71.994	Acanthochromis_polyacanthus
ENSG00000197381	ADARB1	100	79.720	ENSAPOG00000021651	adarb1b	99	78.632	Acanthochromis_polyacanthus
ENSG00000197381	ADARB1	100	93.153	ENSAMEG00000001885	ADARB1	99	93.026	Ailuropoda_melanoleuca
ENSG00000197381	ADARB1	95	73.810	ENSACIG00000024297	-	99	73.214	Amphilophus_citrinellus
ENSG00000197381	ADARB1	100	79.720	ENSACIG00000004927	adarb1b	99	78.693	Amphilophus_citrinellus
ENSG00000197381	ADARB1	100	79.720	ENSAOCG00000004046	adarb1b	99	78.632	Amphiprion_ocellaris
ENSG00000197381	ADARB1	99	77.253	ENSAOCG00000001169	-	99	76.824	Amphiprion_ocellaris
ENSG00000197381	ADARB1	100	79.720	ENSAPEG00000007937	adarb1b	99	78.632	Amphiprion_percula
ENSG00000197381	ADARB1	95	77.943	ENSAPEG00000011629	-	97	78.082	Amphiprion_percula
ENSG00000197381	ADARB1	100	79.720	ENSATEG00000011777	adarb1b	99	79.232	Anabas_testudineus
ENSG00000197381	ADARB1	99	73.305	ENSATEG00000013653	-	99	72.702	Anabas_testudineus
ENSG00000197381	ADARB1	100	85.106	ENSAPLG00000015600	ADARB1	99	84.879	Anas_platyrhynchos
ENSG00000197381	ADARB1	100	85.106	ENSACAG00000009710	ADARB1	99	82.857	Anolis_carolinensis
ENSG00000197381	ADARB1	100	98.288	ENSANAG00000023685	ADARB1	100	98.288	Aotus_nancymaae
ENSG00000197381	ADARB1	100	79.720	ENSACLG00000006817	adarb1b	99	78.663	Astatotilapia_calliptera
ENSG00000197381	ADARB1	98	71.121	ENSACLG00000009531	-	99	70.690	Astatotilapia_calliptera
ENSG00000197381	ADARB1	99	77.525	ENSAMXG00000018363	adarb1b	99	78.094	Astyanax_mexicanus
ENSG00000197381	ADARB1	99	74.605	ENSAMXG00000013675	adarb1a	99	74.714	Astyanax_mexicanus
ENSG00000197381	ADARB1	100	92.867	ENSBTAG00000017486	ADARB1	99	93.017	Bos_taurus
ENSG00000197381	ADARB1	100	97.860	ENSCJAG00000018646	ADARB1	100	97.860	Callithrix_jacchus
ENSG00000197381	ADARB1	100	93.581	ENSCAFG00000011077	ADARB1	100	93.581	Canis_familiaris
ENSG00000197381	ADARB1	100	93.314	ENSCAFG00020019446	ADARB1	100	93.314	Canis_lupus_dingo
ENSG00000197381	ADARB1	100	92.867	ENSCHIG00000018259	ADARB1	100	92.867	Capra_hircus
ENSG00000197381	ADARB1	100	97.432	ENSTSYG00000014318	ADARB1	100	97.432	Carlito_syrichta
ENSG00000197381	ADARB1	93	90.076	ENSCAPG00000014999	ADARB1	99	91.391	Cavia_aperea
ENSG00000197381	ADARB1	100	89.362	ENSCPOG00000022969	ADARB1	97	95.197	Cavia_porcellus
ENSG00000197381	ADARB1	100	98.288	ENSCCAG00000029934	ADARB1	100	98.288	Cebus_capucinus
ENSG00000197381	ADARB1	100	99.429	ENSCATG00000029876	ADARB1	100	99.429	Cercocebus_atys
ENSG00000197381	ADARB1	100	94.437	ENSCLAG00000010595	ADARB1	100	94.437	Chinchilla_lanigera
ENSG00000197381	ADARB1	100	99.429	ENSCSAG00000007489	ADARB1	100	99.429	Chlorocebus_sabaeus
ENSG00000197381	ADARB1	100	87.943	ENSCPBG00000004191	ADARB1	99	84.857	Chrysemys_picta_bellii
ENSG00000197381	ADARB1	100	99.429	ENSCANG00000005413	ADARB1	100	99.429	Colobus_angolensis_palliatus
ENSG00000197381	ADARB1	100	95.150	ENSCGRG00001023922	Adarb1	100	95.150	Cricetulus_griseus_chok1gshd
ENSG00000197381	ADARB1	100	95.150	ENSCGRG00000005984	Adarb1	100	95.150	Cricetulus_griseus_crigri
ENSG00000197381	ADARB1	100	79.720	ENSCSEG00000019137	adarb1b	100	78.551	Cynoglossus_semilaevis
ENSG00000197381	ADARB1	93	60.122	ENSCSEG00000005961	-	97	59.970	Cynoglossus_semilaevis
ENSG00000197381	ADARB1	100	80.420	ENSCVAG00000006161	adarb1b	99	78.125	Cyprinodon_variegatus
ENSG00000197381	ADARB1	91	64.885	ENSCVAG00000010248	-	93	61.732	Cyprinodon_variegatus
ENSG00000197381	ADARB1	100	71.950	ENSDARG00000041609	adarb1a	99	72.532	Danio_rerio
ENSG00000197381	ADARB1	100	80.420	ENSDARG00000003544	adarb1b	99	77.952	Danio_rerio
ENSG00000197381	ADARB1	100	81.560	ENSDNOG00000006954	ADARB1	89	89.340	Dasypus_novemcinctus
ENSG00000197381	ADARB1	100	86.525	ENSDORG00000000619	Adarb1	100	83.934	Dipodomys_ordii
ENSG00000197381	ADARB1	100	89.437	ENSETEG00000007374	ADARB1	100	88.140	Echinops_telfairi
ENSG00000197381	ADARB1	99	39.610	ENSEBUG00000007277	-	83	42.708	Eptatretus_burgeri
ENSG00000197381	ADARB1	94	56.105	ENSEBUG00000004654	-	82	77.778	Eptatretus_burgeri
ENSG00000197381	ADARB1	100	95.292	ENSEASG00005007085	ADARB1	100	95.292	Equus_asinus_asinus
ENSG00000197381	ADARB1	100	95.007	ENSECAG00000019917	ADARB1	100	95.007	Equus_caballus
ENSG00000197381	ADARB1	100	79.720	ENSELUG00000012944	adarb1b	99	76.728	Esox_lucius
ENSG00000197381	ADARB1	98	75.989	ENSELUG00000016573	adarb1a	99	75.174	Esox_lucius
ENSG00000197381	ADARB1	100	93.153	ENSFCAG00000009665	ADARB1	100	93.153	Felis_catus
ENSG00000197381	ADARB1	100	87.755	ENSFALG00000013340	ADARB1	99	84.615	Ficedula_albicollis
ENSG00000197381	ADARB1	100	94.294	ENSFDAG00000007146	ADARB1	100	94.294	Fukomys_damarensis
ENSG00000197381	ADARB1	100	80.420	ENSFHEG00000005765	adarb1b	95	80.098	Fundulus_heteroclitus
ENSG00000197381	ADARB1	99	71.549	ENSFHEG00000015959	-	99	71.408	Fundulus_heteroclitus
ENSG00000197381	ADARB1	91	78.450	ENSGMOG00000005924	adarb1b	86	78.538	Gadus_morhua
ENSG00000197381	ADARB1	93	72.388	ENSGMOG00000002964	-	100	71.981	Gadus_morhua
ENSG00000197381	ADARB1	85	84.298	ENSGALG00000007527	ADARB1	100	84.725	Gallus_gallus
ENSG00000197381	ADARB1	99	70.798	ENSGAFG00000002675	-	95	68.837	Gambusia_affinis
ENSG00000197381	ADARB1	100	80.420	ENSGAFG00000018552	adarb1b	99	77.809	Gambusia_affinis
ENSG00000197381	ADARB1	99	77.273	ENSGACG00000002216	adarb1b	94	77.591	Gasterosteus_aculeatus
ENSG00000197381	ADARB1	98	76.547	ENSGACG00000015240	-	98	76.115	Gasterosteus_aculeatus
ENSG00000197381	ADARB1	97	84.242	ENSGAGG00000013378	ADARB1	99	84.242	Gopherus_agassizii
ENSG00000197381	ADARB1	100	100.000	ENSGGOG00000013244	ADARB1	100	99.730	Gorilla_gorilla
ENSG00000197381	ADARB1	97	64.029	ENSHBUG00000023046	-	87	68.381	Haplochromis_burtoni
ENSG00000197381	ADARB1	100	79.720	ENSHBUG00000004710	adarb1b	99	78.663	Haplochromis_burtoni
ENSG00000197381	ADARB1	100	95.150	ENSHGLG00000005906	ADARB1	100	95.150	Heterocephalus_glaber_female
ENSG00000197381	ADARB1	100	95.150	ENSHGLG00100006988	ADARB1	100	95.150	Heterocephalus_glaber_male
ENSG00000197381	ADARB1	100	78.322	ENSHCOG00000009597	adarb1b	99	77.525	Hippocampus_comes
ENSG00000197381	ADARB1	99	77.021	ENSIPUG00000008384	adarb1b	99	77.589	Ictalurus_punctatus
ENSG00000197381	ADARB1	99	72.453	ENSIPUG00000008816	adarb1	99	72.453	Ictalurus_punctatus
ENSG00000197381	ADARB1	100	93.581	ENSSTOG00000015792	ADARB1	100	93.581	Ictidomys_tridecemlineatus
ENSG00000197381	ADARB1	98	89.796	ENSJJAG00000016847	Adarb1	96	98.305	Jaculus_jaculus
ENSG00000197381	ADARB1	96	75.441	ENSKMAG00000010426	-	98	75.000	Kryptolebias_marmoratus
ENSG00000197381	ADARB1	100	80.420	ENSKMAG00000018557	adarb1b	99	78.205	Kryptolebias_marmoratus
ENSG00000197381	ADARB1	100	79.720	ENSLBEG00000026387	adarb1b	99	79.173	Labrus_bergylta
ENSG00000197381	ADARB1	99	75.352	ENSLBEG00000017967	-	99	75.000	Labrus_bergylta
ENSG00000197381	ADARB1	100	80.851	ENSLACG00000008270	ADARB1	99	79.275	Latimeria_chalumnae
ENSG00000197381	ADARB1	100	79.021	ENSLOCG00000009051	adarb1b	100	76.718	Lepisosteus_oculatus
ENSG00000197381	ADARB1	100	93.530	ENSLAFG00000007480	ADARB1	100	93.530	Loxodonta_africana
ENSG00000197381	ADARB1	100	99.429	ENSMFAG00000011312	ADARB1	100	99.429	Macaca_fascicularis
ENSG00000197381	ADARB1	100	99.429	ENSMMUG00000010695	ADARB1	100	99.429	Macaca_mulatta
ENSG00000197381	ADARB1	100	99.429	ENSMNEG00000031543	ADARB1	100	99.429	Macaca_nemestrina
ENSG00000197381	ADARB1	100	98.582	ENSMLEG00000033846	ADARB1	100	89.069	Mandrillus_leucophaeus
ENSG00000197381	ADARB1	93	72.139	ENSMAMG00000000571	-	97	72.492	Mastacembelus_armatus
ENSG00000197381	ADARB1	100	79.021	ENSMAMG00000013170	adarb1b	99	78.094	Mastacembelus_armatus
ENSG00000197381	ADARB1	100	79.720	ENSMZEG00005017003	adarb1b	99	78.663	Maylandia_zebra
ENSG00000197381	ADARB1	99	70.774	ENSMZEG00005021060	-	95	70.344	Maylandia_zebra
ENSG00000197381	ADARB1	99	85.550	ENSMGAG00000000971	ADARB1	98	85.550	Meleagris_gallopavo
ENSG00000197381	ADARB1	100	93.952	ENSMAUG00000009334	Adarb1	100	93.952	Mesocricetus_auratus
ENSG00000197381	ADARB1	100	94.193	ENSMICG00000008433	ADARB1	100	94.901	Microcebus_murinus
ENSG00000197381	ADARB1	100	95.292	ENSMOCG00000018324	Adarb1	100	95.292	Microtus_ochrogaster
ENSG00000197381	ADARB1	98	74.032	ENSMMOG00000006394	-	98	73.420	Mola_mola
ENSG00000197381	ADARB1	97	78.446	ENSMMOG00000005423	adarb1b	99	78.446	Mola_mola
ENSG00000197381	ADARB1	100	79.720	ENSMALG00000022629	adarb1b	99	77.952	Monopterus_albus
ENSG00000197381	ADARB1	100	94.864	MGP_CAROLIEiJ_G0015481	Adarb1	100	94.864	Mus_caroli
ENSG00000197381	ADARB1	100	94.864	ENSMUSG00000020262	Adarb1	100	94.864	Mus_musculus
ENSG00000197381	ADARB1	100	95.150	MGP_PahariEiJ_G0030894	Adarb1	100	95.150	Mus_pahari
ENSG00000197381	ADARB1	100	94.722	MGP_SPRETEiJ_G0016294	Adarb1	100	94.722	Mus_spretus
ENSG00000197381	ADARB1	100	91.298	ENSMPUG00000010296	ADARB1	100	91.298	Mustela_putorius_furo
ENSG00000197381	ADARB1	100	90.456	ENSMLUG00000011328	ADARB1	100	90.456	Myotis_lucifugus
ENSG00000197381	ADARB1	100	94.864	ENSNGAG00000021602	Adarb1	100	94.864	Nannospalax_galili
ENSG00000197381	ADARB1	99	71.246	ENSNBRG00000013437	-	99	70.822	Neolamprologus_brichardi
ENSG00000197381	ADARB1	100	79.720	ENSNBRG00000015066	adarb1b	99	78.663	Neolamprologus_brichardi
ENSG00000197381	ADARB1	100	99.460	ENSNLEG00000002514	ADARB1	100	99.460	Nomascus_leucogenys
ENSG00000197381	ADARB1	98	77.366	ENSMEUG00000009400	ADARB1	99	77.366	Notamacropus_eugenii
ENSG00000197381	ADARB1	81	94.881	ENSOPRG00000000350	-	71	94.881	Ochotona_princeps
ENSG00000197381	ADARB1	99	92.006	ENSODEG00000014508	ADARB1	99	92.006	Octodon_degus
ENSG00000197381	ADARB1	100	79.720	ENSONIG00000004464	adarb1b	93	78.409	Oreochromis_niloticus
ENSG00000197381	ADARB1	98	70.344	ENSONIG00000007354	-	99	68.194	Oreochromis_niloticus
ENSG00000197381	ADARB1	100	84.397	ENSOANG00000012491	ADARB1	97	83.978	Ornithorhynchus_anatinus
ENSG00000197381	ADARB1	100	94.722	ENSOCUG00000004683	ADARB1	96	93.620	Oryctolagus_cuniculus
ENSG00000197381	ADARB1	93	56.662	ENSORLG00000020682	-	95	56.682	Oryzias_latipes
ENSG00000197381	ADARB1	100	79.720	ENSORLG00000018106	adarb1b	99	77.952	Oryzias_latipes
ENSG00000197381	ADARB1	100	79.720	ENSORLG00020012709	adarb1b	99	77.952	Oryzias_latipes_hni
ENSG00000197381	ADARB1	93	56.202	ENSORLG00020013949	-	95	56.836	Oryzias_latipes_hni
ENSG00000197381	ADARB1	100	79.720	ENSORLG00015008706	adarb1b	94	77.652	Oryzias_latipes_hsok
ENSG00000197381	ADARB1	93	57.427	ENSORLG00015016287	-	92	57.450	Oryzias_latipes_hsok
ENSG00000197381	ADARB1	100	79.720	ENSOMEG00000010493	adarb1b	99	77.525	Oryzias_melastigma
ENSG00000197381	ADARB1	99	59.626	ENSOMEG00000010969	-	99	60.489	Oryzias_melastigma
ENSG00000197381	ADARB1	100	94.076	ENSOGAG00000017167	ADARB1	100	94.076	Otolemur_garnettii
ENSG00000197381	ADARB1	100	89.392	ENSOARG00000012452	ADARB1	87	88.797	Ovis_aries
ENSG00000197381	ADARB1	100	100.000	ENSPPAG00000027139	ADARB1	100	99.865	Pan_paniscus
ENSG00000197381	ADARB1	100	93.010	ENSPPRG00000012281	ADARB1	100	93.010	Panthera_pardus
ENSG00000197381	ADARB1	100	83.310	ENSPTIG00000007673	ADARB1	100	83.126	Panthera_tigris_altaica
ENSG00000197381	ADARB1	100	100.000	ENSPTRG00000013997	ADARB1	100	99.865	Pan_troglodytes
ENSG00000197381	ADARB1	100	99.429	ENSPANG00000020871	ADARB1	100	99.190	Papio_anubis
ENSG00000197381	ADARB1	99	74.786	ENSPKIG00000014295	adarb1b	99	74.713	Paramormyrops_kingsleyae
ENSG00000197381	ADARB1	100	79.720	ENSPKIG00000010029	adarb1b	99	78.094	Paramormyrops_kingsleyae
ENSG00000197381	ADARB1	100	85.816	ENSPSIG00000006201	ADARB1	99	84.143	Pelodiscus_sinensis
ENSG00000197381	ADARB1	98	77.586	ENSPMGG00000011320	adarb1a	93	77.299	Periophthalmus_magnuspinnatus
ENSG00000197381	ADARB1	100	93.812	ENSPEMG00000022360	Adarb1	100	93.812	Peromyscus_maniculatus_bairdii
ENSG00000197381	ADARB1	99	66.431	ENSPMAG00000007453	-	99	66.099	Petromyzon_marinus
ENSG00000197381	ADARB1	65	69.792	ENSPMAG00000006731	-	97	66.406	Petromyzon_marinus
ENSG00000197381	ADARB1	100	82.979	ENSPCIG00000024187	ADARB1	99	82.546	Phascolarctos_cinereus
ENSG00000197381	ADARB1	100	80.420	ENSPFOG00000002576	adarb1b	99	77.952	Poecilia_formosa
ENSG00000197381	ADARB1	99	70.721	ENSPFOG00000002564	-	99	70.297	Poecilia_formosa
ENSG00000197381	ADARB1	100	80.420	ENSPLAG00000003525	adarb1b	99	77.872	Poecilia_latipinna
ENSG00000197381	ADARB1	93	68.421	ENSPLAG00000011630	-	78	66.802	Poecilia_latipinna
ENSG00000197381	ADARB1	98	71.121	ENSPMEG00000009668	-	93	70.833	Poecilia_mexicana
ENSG00000197381	ADARB1	100	80.420	ENSPMEG00000014365	adarb1b	99	77.952	Poecilia_mexicana
ENSG00000197381	ADARB1	100	80.420	ENSPREG00000016600	adarb1b	99	77.952	Poecilia_reticulata
ENSG00000197381	ADARB1	99	70.370	ENSPREG00000018254	-	97	68.898	Poecilia_reticulata
ENSG00000197381	ADARB1	100	100.000	ENSPPYG00000011514	ADARB1	100	99.572	Pongo_abelii
ENSG00000197381	ADARB1	60	91.875	ENSPCAG00000012027	-	56	95.181	Procavia_capensis
ENSG00000197381	ADARB1	100	96.719	ENSPCOG00000020406	ADARB1	100	96.719	Propithecus_coquereli
ENSG00000197381	ADARB1	91	88.300	ENSPVAG00000012197	ADARB1	99	88.144	Pteropus_vampyrus
ENSG00000197381	ADARB1	99	70.680	ENSPNYG00000016509	-	99	70.255	Pundamilia_nyererei
ENSG00000197381	ADARB1	100	79.720	ENSPNYG00000000542	adarb1b	99	78.663	Pundamilia_nyererei
ENSG00000197381	ADARB1	99	77.809	ENSPNAG00000013623	adarb1b	99	78.378	Pygocentrus_nattereri
ENSG00000197381	ADARB1	75	82.407	ENSPNAG00000022697	adarb1a	99	70.045	Pygocentrus_nattereri
ENSG00000197381	ADARB1	100	95.150	ENSRNOG00000001227	Adarb1	99	94.421	Rattus_norvegicus
ENSG00000197381	ADARB1	100	99.429	ENSRBIG00000033033	ADARB1	100	99.190	Rhinopithecus_bieti
ENSG00000197381	ADARB1	100	99.429	ENSRROG00000042856	ADARB1	100	99.515	Rhinopithecus_roxellana
ENSG00000197381	ADARB1	100	96.454	ENSSBOG00000021021	ADARB1	100	98.033	Saimiri_boliviensis_boliviensis
ENSG00000197381	ADARB1	52	79.508	ENSSHAG00000006483	-	99	79.235	Sarcophilus_harrisii
ENSG00000197381	ADARB1	94	82.222	ENSSFOG00015008633	adarb1b	99	76.259	Scleropages_formosus
ENSG00000197381	ADARB1	96	75.362	ENSSFOG00015016632	adarb1b	99	71.674	Scleropages_formosus
ENSG00000197381	ADARB1	100	79.021	ENSSMAG00000004206	adarb1b	99	71.897	Scophthalmus_maximus
ENSG00000197381	ADARB1	95	73.810	ENSSMAG00000009423	-	98	73.512	Scophthalmus_maximus
ENSG00000197381	ADARB1	100	79.720	ENSSDUG00000010164	adarb1b	99	78.236	Seriola_dumerili
ENSG00000197381	ADARB1	99	75.892	ENSSDUG00000018690	-	94	73.786	Seriola_dumerili
ENSG00000197381	ADARB1	95	76.006	ENSSLDG00000013681	-	99	75.559	Seriola_lalandi_dorsalis
ENSG00000197381	ADARB1	100	79.720	ENSSLDG00000021316	adarb1b	99	78.236	Seriola_lalandi_dorsalis
ENSG00000197381	ADARB1	89	81.895	ENSSARG00000004655	ADARB1	88	81.702	Sorex_araneus
ENSG00000197381	ADARB1	100	81.560	ENSSPUG00000014163	ADARB1	99	80.830	Sphenodon_punctatus
ENSG00000197381	ADARB1	98	77.188	ENSSPAG00000003299	-	98	76.758	Stegastes_partitus
ENSG00000197381	ADARB1	100	79.720	ENSSPAG00000005613	adarb1b	99	78.490	Stegastes_partitus
ENSG00000197381	ADARB1	100	88.810	ENSSSCG00000012089	ADARB1	100	88.810	Sus_scrofa
ENSG00000197381	ADARB1	100	83.688	ENSTGUG00000011159	ADARB1	99	83.143	Taeniopygia_guttata
ENSG00000197381	ADARB1	99	76.252	ENSTRUG00000006297	-	99	75.788	Takifugu_rubripes
ENSG00000197381	ADARB1	100	80.420	ENSTRUG00000006823	adarb1b	99	78.267	Takifugu_rubripes
ENSG00000197381	ADARB1	100	79.021	ENSTNIG00000008894	adarb1b	93	77.305	Tetraodon_nigroviridis
ENSG00000197381	ADARB1	99	75.177	ENSTNIG00000014498	-	99	75.216	Tetraodon_nigroviridis
ENSG00000197381	ADARB1	100	92.297	ENSTBEG00000014798	ADARB1	100	92.297	Tupaia_belangeri
ENSG00000197381	ADARB1	100	91.348	ENSTTRG00000002681	ADARB1	100	91.348	Tursiops_truncatus
ENSG00000197381	ADARB1	100	87.234	ENSUAMG00000005024	ADARB1	98	93.312	Ursus_americanus
ENSG00000197381	ADARB1	100	92.867	ENSUMAG00000025411	ADARB1	100	92.867	Ursus_maritimus
ENSG00000197381	ADARB1	91	84.848	ENSVPAG00000011520	-	60	96.364	Vicugna_pacos
ENSG00000197381	ADARB1	100	93.438	ENSVVUG00000023911	ADARB1	100	93.438	Vulpes_vulpes
ENSG00000197381	ADARB1	99	80.973	ENSXETG00000018692	adarb1	99	80.505	Xenopus_tropicalis
ENSG00000197381	ADARB1	98	70.833	ENSXCOG00000020590	-	97	70.546	Xiphophorus_couchianus
ENSG00000197381	ADARB1	100	80.420	ENSXCOG00000014535	adarb1b	99	77.809	Xiphophorus_couchianus
ENSG00000197381	ADARB1	100	80.420	ENSXMAG00000002053	adarb1b	99	77.809	Xiphophorus_maculatus
ENSG00000197381	ADARB1	99	70.513	ENSXMAG00000018829	-	97	69.177	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	21873635.	IBA	Function
GO:0003726	double-stranded RNA adenosine deaminase activity	21873635.	IBA	Function
GO:0003729	mRNA binding	9149227.	TAS	Function
GO:0005515	protein binding	21847096.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	18178553.21289159.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006382	adenosine to inosine editing	21873635.	IBA	Process
GO:0006382	adenosine to inosine editing	18178553.21289159.	IDA	Process
GO:0006382	adenosine to inosine editing	-	TAS	Process
GO:0006396	RNA processing	21873635.	IBA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0007274	neuromuscular synaptic transmission	-	IEA	Process
GO:0008251	tRNA-specific adenosine deaminase activity	21873635.	IBA	Function
GO:0008285	negative regulation of cell proliferation	18178553.	IDA	Process
GO:0021610	facial nerve morphogenesis	-	IEA	Process
GO:0021618	hypoglossal nerve morphogenesis	-	IEA	Process
GO:0021965	spinal cord ventral commissure morphogenesis	-	IEA	Process
GO:0030336	negative regulation of cell migration	18178553.	IDA	Process
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	21289159.	IDA	Process
GO:0045070	positive regulation of viral genome replication	21289159.	IMP	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0050884	neuromuscular process controlling posture	-	IEA	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:0051726	regulation of cell cycle	18178553.	IDA	Process
GO:0060384	innervation	-	IEA	Process
GO:0060415	muscle tissue morphogenesis	-	IEA	Process
GO:0061744	motor behavior	-	IEA	Process
GO:0097049	motor neuron apoptotic process	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.