EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27100483The role of annexin A4 in cancer.Front Biosci (Landmark Ed)2016 Jun 1Yao H-
27491820Annexin A4-nuclear factor-??B feedback circuit regulates cell malignant behavior and tumor growth in gallbladder cancer.Sci Rep2016 Aug 5Yao HSdoi: 10.1038/srep31056.
30066907Lewis(y) antigen-mediated positive feedback loop induces and promotes chemotherapeutic resistance in ovarian cancer.Int J Oncol2018 OctLiu Jdoi: 10.3892/ijo.2018.4496
24223161Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.PLoS One2013 Nov 6Gaudio Edoi: 10.1371/journal.pone.0078610
26048190Annexin A4 and cancer.Clin Chim Acta2015 Jul 20Wei Bdoi: 10.1016/j.cca.2015.05.016
27650619The Role of Annexin A4 in Triple-Negative Breast Cancer Progression and Its Clinical Application.Ann Clin Lab Sci2016 SepZhang ZG-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2697815525'UTRnovel0.24
BLCAchr269788074SilentnovelV10V0.07
BLCAchr2697815525'UTRnovel0.49
BLCAchr269810651Missense_Mutationrs144937233R152Q0.13
BLCAchr2697815475'UTRnovel0.29
BRCAchr269806495Missense_MutationNAM101I0.2
BRCAchr269820765Missense_MutationNAD284N0.38
BRCAchr269788052Splice_SitenovelX4_splice0.22
BRCAchr269806397Missense_MutationNAD69N0.13
CESCchr269807979Missense_MutationnovelS127N0.56
COADchr269818625Missense_MutationNAQ219E0.37
COADchr269818650Missense_MutationnovelK227T0.23
COADchr2698255593'UTRrs7673145280.2
COADchr269804547Missense_Mutationrs376382183A38T0.38
COADchr269820742Missense_MutationNAS276F0.2
COADchr269810853Intronnovel0.35
COADchr269810674Splice_SiteNAX159_splice0.12
ESCAchr269806409Missense_MutationnovelE73K0.36
ESCAchr269806447Missense_MutationnovelM85I0.09
ESCAchr2698262573'UTRnovel0.4
GBMchr269819301Missense_MutationnovelS249Y0.29
GBMchr269810653Missense_MutationnovelV153L0.08
HNSCchr269820816Missense_MutationnovelI301F0.59
HNSCchr269788101Frame_Shift_DelnovelE20Kfs*60.28
KIRCchr269818604Missense_MutationNAD212N0.22
KIRPchr269812672Missense_MutationNAN166I0.36
LIHCchr269788070Missense_MutationNAT9I0.11
LUADchr269825495Missense_MutationnovelL316V0.16
LUADchr269820698Splice_Siters4493288X262_splice0.12
LUADchr269816132Missense_MutationnovelG189E0.09
LUSCchr269810720Intronnovel0.3
LUSCchr269825480Missense_MutationnovelK311E0.13
LUSCchr269788141Missense_MutationNAG33C0.31
LUSCchr269816129Missense_MutationnovelW188L0.29
OVchr269788080SilentnovelA12A0.06
OVchr269788065SilentnovelG7G0.08
PRADchr269818602Missense_MutationNAF211C0.08
PRADchr269820750Nonsense_MutationnovelE279*0.49
READchr2698257403'UTRnovel0.27
SARCchr269816192Missense_MutationnovelH209L0.27
SKCMchr269810623Missense_Mutationrs755577388R143C0.44
SKCMchr269810623Missense_Mutationrs755577388R143C0.11
SKCMchr269825510Missense_MutationNAD321N0.5
STADchr269806440Missense_MutationNAV83E0.17
STADchr269806488Missense_MutationnovelR99M0.1
STADchr269812691Silentrs141776547L172L0.34
STADchr269804547Missense_Mutationrs376382183A38T0.34
STADchr269806396Silentrs148077345D68D0.44
STADchr269788128SilentNAA28A0.3
STADchr269810603Missense_MutationNAR136L0.39
THYMchr269781516Splice_Regionnovel0.28
UCECchr269810829Intronnovel0.43
UCECchr2698263283'UTRnovel0.36
UCECchr269825501Missense_MutationnovelG318R0.17
UCECchr269816152Missense_MutationnovelL196I0.08
UCECchr2698256173'UTRnovel0.39
UCECchr2698262573'UTRnovel0.29
UCECchr269804537Silentrs151130421T34T0.12
UCECchr269788140Splice_Regionrs187492712L32L0.48
UCECchr269806427Missense_MutationNAE79K0.42
UCECchr269806453SilentnovelT87T0.37
UCECchr269804587Missense_Mutationrs761374777R51H0.34
UCECchr2698260153'UTRnovel0.57
UCECchr269816177Missense_Mutationrs373624358R204Q0.32
UCECchr269812651Splice_SitenovelX160_splice0.32
UCECchr269788063Nonsense_MutationNAG7*0.2
UCECchr269820811Missense_Mutationrs765123505S299L0.26
UCECchr269804538Missense_MutationNAD35N0.38
UCECchr269810829Intronnovel0.5
UCECchr2698262743'UTRnovel0.5
UCECchr269820787Missense_MutationnovelR291K0.1
UCECchr269807959SilentnovelP120P0.19
UCECchr269810877Intronnovel0.46
UCECchr269806453SilentnovelT87T0.44
UCECchr269819331Missense_Mutationrs140302494S259L0.55
UCECchr2698255453'UTRnovel0.35
UCECchr2698263853'UTRnovel0.23
UCECchr2698261483'UTRnovel0.2
UCECchr269781518Splice_SiteNA0.49
UCECchr2698262623'UTRnovel0.3
UCECchr269810803Intronnovel0.24
UCECchr269804621Silentrs766437171I62I0.33
UCECchr2698260903'UTRnovel0.24
UCECchr269807952Missense_Mutationrs144504684R118Q0.41
UCECchr269819331Missense_Mutationrs140302494S259L0.38
UCECchr269820732Missense_MutationnovelV273M0.37
UCECchr269807990Nonsense_MutationnovelQ131*0.25
UCECchr2698263573'UTRnovel0.41
UCECchr269807913Missense_Mutationrs778785400G105D0.46
UCECchr2698262573'UTRnovel0.48
UCECchr269788137SilentNAG31G0.53
UCECchr269807996Nonsense_Mutationrs774777486Q133*0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.02430.08832
PAADDEL0.04890.2014
READDEL0.06670.19022

Survival Analysis
CancerP-value Q-value
THYM0.018

Kaplan-Meier Survival Analysis

KIRC0.0057

Kaplan-Meier Survival Analysis

ACC0.044

Kaplan-Meier Survival Analysis

KIRP0.00039

Kaplan-Meier Survival Analysis

PAAD0.032

Kaplan-Meier Survival Analysis

LAML0.0079

Kaplan-Meier Survival Analysis

KICH0.043

Kaplan-Meier Survival Analysis

GBM0.0036

Kaplan-Meier Survival Analysis

LGG0.0003

Kaplan-Meier Survival Analysis

CHOL0.034

Kaplan-Meier Survival Analysis

UVM0.0004

Kaplan-Meier Survival Analysis

OV0.0011

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000196975 (Gene tree)
Gene ID
307
Gene Symbol
ANXA4
Alias
ANX4
Full Name
annexin A4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
183,001 bases
Position
chr2:69,644,100-69,827,100
Accession
542
RBP type
non-canonical RBP
Summary
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000409920ANXA4-2021414-ENSP00000386756299 (aa)-Q6P452
ENST00000477632ANXA4-2093949--- (aa)--
ENST00000418066ANXA4-203905--- (aa)--
ENST00000471395ANXA4-2074418--- (aa)--
ENST00000394295ANXA4-2012799XM_017003943ENSP00000377833321 (aa)XP_016859432P09525
ENST00000460439ANXA4-204543--- (aa)--
ENST00000468815ANXA4-206521-ENSP000004894908 (aa)-A0A0U1RRE7
ENST00000487351ANXA4-211552--- (aa)--
ENST00000472124ANXA4-208376-ENSP000004894647 (aa)-A0A1Y8EKW3
ENST00000460942ANXA4-205576--- (aa)--
ENST00000635311ANXA4-2121492-ENSP00000489316142 (aa)-B4E1S2
ENST00000484219ANXA4-210338--- (aa)--
Gene Model
Click here to download ENSG00000196975's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000196975Carcinoma, Non-Small-Cell Lung5.3940000E-005-
ENSG00000196975Carcinoma, Non-Small-Cell Lung6.2340000E-005-
ENSG00000196975Phospholipids5E-623362303
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000196975rs7597155269758303APalmitoleic acid (16:1n-7) levels23362303unit increase0.0149EFO_0005110
ENSG00000196975rs62133983269749252GAtrial fibrillation28416818[1.06-1.12]1.09EFO_0000275
ENSG00000196975rs6546550269811100CPrevalent atrial fibrillation284168181.08-1.161.12EFO_0000275
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196975's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004859phospholipase inhibitor activity2970257.NASFunction
GO:0005509calcium ion binding21873635.IBAFunction
GO:0005509calcium ion binding20237821.IDAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding21044950.IPIFunction
GO:0005544calcium-dependent phospholipid binding2138016.IDAFunction
GO:0005544calcium-dependent phospholipid binding2970257.NASFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16687573.20237821.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm20237821.IDAComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane16687573.IDAComponent
GO:0006357regulation of transcription by RNA polymerase II20237821.IDAProcess
GO:0007165signal transduction16130169.TASProcess
GO:0007219Notch signaling pathway21873635.IBAProcess
GO:0008201heparin binding21873635.IBAFunction
GO:0009986cell surface22056994.IDAComponent
GO:0012506vesicle membrane16687573.IDAComponent
GO:0030855epithelial cell differentiation21873635.IBAProcess
GO:0030855epithelial cell differentiation21492153.IEPProcess
GO:0031965nuclear membrane16687573.IDAComponent
GO:0032088negative regulation of NF-kappaB transcription factor activity20237821.IDAProcess
GO:0035374chondroitin sulfate binding21873635.IBAFunction
GO:0042802identical protein binding21873635.IBAFunction
GO:0042802identical protein binding16687573.IPIFunction
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0043086negative regulation of catalytic activity-IEAProcess
GO:0048306calcium-dependent protein binding21873635.IBAFunction
GO:0048306calcium-dependent protein binding15226301.20237821.IPIFunction
GO:0048471perinuclear region of cytoplasm16687573.IDAComponent
GO:0051059NF-kappaB binding20237821.IPIFunction
GO:0062023collagen-containing extracellular matrix25037231.28675934.HDAComponent
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:2000483negative regulation of interleukin-8 secretion22056994.IMPProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us