EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15665816	Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1.	Cell Death Differ	2005 Apr	Huang BH	-
23975430	Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer.	Oncogene	2014 Jul 10	Roy SS	doi: 10.1038/onc.2013.332
23440245	A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.	Blood	2013 Apr 25	Santoro F	doi: 10.1182/blood-2012-10-461988
21143702	Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.	Cancer Sci	2011 Feb	Campos B	doi: 10.1111/j.1349-7006.2010.01792.x
19416910	Genetic dissection of histone deacetylase requirement in tumor cells.	Proc Natl Acad Sci U S A	2009 May 12	Haberland M	doi: 10.1073/pnas.0903139106
17935135	Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors.	Int J Cancer	2008 Jan 15	Pluemsampant S	-
25605253	Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation.	Oncotarget	2015 Sep 22	Seo SK	doi: 10.18632/oncotarget.3100.
21527555	Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.	Cancer Res	2011 Jul 1	Ramsey MR	doi: 10.1158/0008-5472.CAN-11-0046
20398369	HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells.	Mol Cancer	2010 Apr 16	Sch??ler S	doi: 10.1186/1476-4598-9-80.
22641068	Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.	Gastroenterology	2012 Sep	Buurman R	doi: 10.1053/j.gastro.2012.05.033
26729194	p21 and CK2 interaction-mediated HDAC2 phosphorylation modulates KLF4 acetylation to regulate bladder cancer cell proliferation.	Tumour Biol	2016 Jun	Jia ZM	doi: 10.1007/s13277-015-4618-1
29333444	MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer.	Biomed Res Int	2017	Wei J	doi: 10.1155/2017/5348490
18212746	Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy.	Br J Cancer	2008 Feb 12	Weichert W	doi: 10.1038/sj.bjc.6604199
30250993	Expression profiles of histone modification genes in gastric cancer progression.	Mol Biol Rep	2018 Dec	Orenay-Boyacioglu S	doi: 10.1007/s11033-018-4389-z
19099586	Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.	BMC Cancer	2008 Dec 19	Fritzsche FR	doi: 10.1186/1471-2407-8-381.
23110995	X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer.	Radiat Oncol	2012 Oct 31	Han Y	doi: 10.1186/1748-717X-7-183.
24218540	Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis.	J Pharmacol Exp Ther	2014 Jan	Ravillah D	doi: 10.1124/jpet.113.208645
18408217	Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.	J Biol Chem	2008 Jun 13	Ishdorj G	doi: 10.1074/jbc.M710177200
23251689	Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.	PLoS One	2012	Wang G	doi: 10.1371/journal.pone.0052095
17786334	Expression profile of class I histone deacetylases in human cancer tissues.	Oncol Rep	2007 Oct	Nakagawa M	-
19724929	Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models.	Int J Oncol	2009 Oct	Bracker TU	-
22492270	HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.	J Cell Biochem	2012 Jun	Jung KH	doi: 10.1002/jcb.24090.
23544610	HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9.	Clin Invest Med	2013 Apr 1	Wang F	-
20190809	Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression.	Oncogene	2010 May 27	Li P	doi: 10.1038/onc.2010.51
26683361	The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.	Oncotarget	2016 Jan 26	Huang R	doi: 10.18632/oncotarget.6618.
20585871	Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.	Ann Surg Oncol	2010 Dec	Mutze K	doi: 10.1245/s10434-010-1182-1
23926105	Loss of epigenetic Kruppel-like factor 4 histone deacetylase (KLF-4-HDAC)-mediated transcriptional suppression is crucial in increasing vascular endothelial growth factor (VEGF) expression in breast cancer.	J Biol Chem	2013 Sep 20	Ray A	doi: 10.1074/jbc.M113.481184
19912635	High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo.	BMC Cancer	2009 Nov 13	Lehmann A	doi: 10.1186/1471-2407-9-395.
24390319	VPA inhibits renal cancer cell migration by targeting HDAC2 and down-regulating HIF-1α.	Mol Biol Rep	2014 Mar	Yang FQ	doi: 10.1007/s11033-013-2996-2
19383825	Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.	Clin Cancer Res	2009 May 1	Suzuki J	doi: 10.1158/1078-0432.CCR-08-2319
22944197	Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers.	Urol Oncol	2013 Nov	Niegisch G	doi: 10.1016/j.urolonc.2012.06.015
26846508	Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription.	Cancer Chemother Pharmacol	2016 Mar	Ye P	doi: 10.1007/s00280-016-2979-9
18347167	Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo.	Clin Cancer Res	2008 Mar 15	Weichert W	doi: 10.1158/1078-0432.CCR-07-0990.
25942572	Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers.	Cell Cycle	2015	Bhaskara S	doi: 10.1080/15384101.2015.1042634.
15144953	Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.	Cancer Cell	2004 May	Zhu P	-
26352599	HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population.	Oncol Rep	2015 Nov	Ler SY	doi: 10.3892/or.2015.4263
28839465	FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.	Theranostics	2017 Jul 22	Zhu W	doi: 10.7150/thno.18067

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	113971079	5'UTR	novel		0.19
BLCA	chr6	113944350	Silent	novel	A384A	0.42
BLCA	chr6	113953306	Missense_Mutation	NA	E204K	0.1
BLCA	chr6	113953377	Missense_Mutation	novel	H180R	0.08
BLCA	chr6	113943392	Missense_Mutation	novel	R446K	0.19
BRCA	chr6	113953393	Missense_Mutation	NA	D175N	0.16
BRCA	chr6	113953414	Missense_Mutation	NA	H168Y	0.18
BRCA	chr6	113941060	Nonstop_Mutation	novel	489Rext2	0.07
BRCA	chr6	113956047	Nonsense_Mutation	novel	Y153*	0.56
CESC	chr6	113944295	Missense_Mutation	novel	D403N	0.09
CESC	chr6	113944296	Frame_Shift_Ins	novel	*D403Rfs16**	0.08
CESC	chr6	113970876	Frame_Shift_Del	rs759078191	*V12Sfs20**	0.37
CESC	chr6	113949209	Missense_Mutation	novel	D231N	0.15
CESC	chr6	113946070	Missense_Mutation	novel	R307H	0.07
CESC	chr6	113970943	5'UTR	novel		0.44
CESC	chr6	113946106	Frame_Shift_Del	novel	*P295Ifs13**	0.24
CESC	chr6	113953292	Silent	novel	G208G	0.19
COAD	chr6	113943504	Nonsense_Mutation	rs267600769	R409*	0.35
COAD	chr6	113943500	Missense_Mutation	NA	A410V	0.21
COAD	chr6	113956131	Nonsense_Mutation	NA	R127*	0.26
COAD	chr6	113959917	Frame_Shift_Del	novel	*M52Wfs14**	0.12
COAD	chr6	113943354	Frame_Shift_Del	NA	*T459Qfs47**	0.4
COAD	chr6	113956695	Splice_Site	NA	X95_splice	0.26
COAD	chr6	113946115	Missense_Mutation	NA	F292C	0.21
GBM	chr6	113944331	Missense_Mutation	NA	H391D	0.43
GBM	chr6	113945437	Missense_Mutation	NA	G339E	0.43
HNSC	chr6	113949204	Silent	novel	G232G	0.3
HNSC	chr6	113941720	Frame_Shift_Ins	novel	*T475Nfs27**	0.41
HNSC	chr6	113946071	Missense_Mutation	novel	R307C	0.55
HNSC	chr6	113946072	Silent	novel	I306I	0.56
HNSC	chr6	113943473	Missense_Mutation	novel	E419V	0.18
KIRC	chr6	113958701	Silent	rs149797556	L77L	0.04
KIRP	chr6	113943481	Silent	NA	A416A	0.56
LAML	chr6	113953393	Missense_Mutation	NA	D175N	0.18
LGG	chr6	113956653	Frame_Shift_Del	NA	F108*	0.2
LGG	chr6	113958655	Nonsense_Mutation	novel	Q93*	0.37
LGG	chr6	113956115	Frame_Shift_Ins	novel	*M132Nfs4**	0.49
LIHC	chr6	113956114	Missense_Mutation	novel	M132I	0.66
LIHC	chr6	113943418	Missense_Mutation	NA	D437E	0.37
LIHC	chr6	113943418	Missense_Mutation	NA	D437E	0.16
LUAD	chr6	113956151	Missense_Mutation	novel	A120V	0.19
LUAD	chr6	113959945	Missense_Mutation	NA	L42F	0.27
LUAD	chr6	113959989	Missense_Mutation	NA	G28R	0.05
LUAD	chr6	113941061	Silent	NA	P488P	0.28
LUAD	chr6	113956673	Missense_Mutation	NA	P102A	0.11
LUAD	chr6	113946119	Frame_Shift_Ins	novel	*T291Sfs9**	0.07
LUAD	chr6	113958699	Missense_Mutation	novel	R78L	0.27
LUAD	chr6	113949051	Missense_Mutation	NA	A257T	0.24
LUAD	chr6	113943363	Missense_Mutation	NA	D456N	0.5
LUAD	chr6	113958725	Silent	NA	H69H	0.12
LUSC	chr6	113956146	Missense_Mutation	novel	A122S	0.19
LUSC	chr6	113945439	Silent	novel	F338F	0.18
LUSC	chr6	113956652	Missense_Mutation	NA	E109Q	0.32
MESO	chr6	113971002	5'UTR	rs749215157		0.21
OV	chr6	113943491	Splice_Site	novel	X408_splice	0.53
PCPG	chr6	113949062	Missense_Mutation	NA	Y253C	0.06
PRAD	chr6	113946071	Missense_Mutation	novel	R307S	0.38
PRAD	chr6	113956079	Frame_Shift_Ins	novel	*K144Rfs12**	0.47
PRAD	chr6	113956080	Nonsense_Mutation	novel	A143_K144ins*	0.41
READ	chr6	113945452	Missense_Mutation	NA	Y334C	0.31
READ	chr6	113956629	Silent	rs373430125	G116G	0.17
READ	chr6	113953323	Nonsense_Mutation	NA	S198*	0.34
SKCM	chr6	113953403	Silent	novel	V171V	0.11
SKCM	chr6	113953306	Missense_Mutation	NA	E204K	0.07
SKCM	chr6	113956680	Missense_Mutation	NA	E99D	0.4
SKCM	chr6	113959990	Silent	NA	Q27Q	0.36
STAD	chr6	113943504	Nonsense_Mutation	rs267600769	R409*	0.46
STAD	chr6	113946073	Missense_Mutation	NA	I306N	0.06
STAD	chr6	113953387	Missense_Mutation	novel	D177N	0.4
STAD	chr6	113959931	Missense_Mutation	novel	G47D	0.14
STAD	chr6	113945410	Missense_Mutation	NA	P348H	0.07
UCEC	chr6	113941029	3'UTR	novel		0.33
UCEC	chr6	113953315	Missense_Mutation	NA	K201E	0.26
UCEC	chr6	113944406	Missense_Mutation	novel	R366C	0.15
UCEC	chr6	113943504	Nonsense_Mutation	rs267600769	R409*	0.44
UCEC	chr6	113943354	Frame_Shift_Del	NA	*T459Qfs47**	0.39
UCEC	chr6	113946032	Missense_Mutation	novel	A320T	0.32
UCEC	chr6	113959961	Missense_Mutation	novel	R37H	0.48
UCEC	chr6	113956039	Missense_Mutation	novel	I157M	0.05
UCEC	chr6	113956057	Missense_Mutation	NA	F151L	0.06
UCEC	chr6	113956656	Silent	NA	L107L	0.23
UCEC	chr6	113944386	Silent	novel	R372R	0.56
UCEC	chr6	113956670	Missense_Mutation	novel	V103M	0.5
UCEC	chr6	113958706	Missense_Mutation	novel	F76V	0.29
UCEC	chr6	113941763	Missense_Mutation	novel	V461I	0.4
UCEC	chr6	113960010	Missense_Mutation	novel	G21R	0.29
UCEC	chr6	113943354	Frame_Shift_Del	NA	*T459Qfs47**	0.45
UCEC	chr6	113941088	Splice_Region	novel	G479G	0.14
UCEC	chr6	113971097	5'UTR	NA		0.53
UCEC	chr6	113943504	Nonsense_Mutation	rs267600769	R409*	0.37
UCEC	chr6	113943354	Frame_Shift_Del	NA	*T459Qfs47**	0.42
UCEC	chr6	113958746	Silent	rs776039140	A62A	0.43
UCEC	chr6	113949082	Silent	novel	I246I	0.41
UCEC	chr6	113949076	Silent	NA	K248K	0.06
UCEC	chr6	113959917	Frame_Shift_Del	novel	*M52Wfs14**	0.5
UCEC	chr6	113941738	Missense_Mutation	novel	D469G	0.1
UCEC	chr6	113949243	Frame_Shift_Del	novel	*G220Afs10**	0.2
UCEC	chr6	113940865	3'UTR	novel		0.21
UCEC	chr6	113940994	3'UTR	novel		0.11
UCEC	chr6	113945367	Missense_Mutation	NA	K362N	0.25
UCEC	chr6	113943458	Missense_Mutation	novel	S424F	0.28
UCEC	chr6	113945439	Silent	novel	F338F	0.23
UCEC	chr6	113953329	Missense_Mutation	novel	T196M	0.26
UCEC	chr6	113959962	Missense_Mutation	novel	R37C	0.26
UCEC	chr6	113940860	3'UTR	novel		0.64
UCS	chr6	113943369	Missense_Mutation	novel	T454A	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.375	3.4915e-05
DLBC	DEL	0.2708	0.00052595
ESCA	DEL	0.212	0.036953
GBM	DEL	0.2149	1.056e-05
KIRC	DEL	0.233	7.439e-11
LGG	DEL	0.1384	0.0054594
LUAD	DEL	0.4109	0.0021365
MESO	DEL	0.4368	0.05642
PAAD	DEL	0.3641	0.11274
SKCM	DEL	0.5368	1.5442e-06
STAD	DEL	0.1361	0.0044196
THYM	DEL	0.1301	0.10691

Survival Analysis

Cancer	P-value	Q-value
THYM	0.017	Kaplan-Meier Survival Analysis
SARC	0.00015	Kaplan-Meier Survival Analysis
MESO	0.0039	Kaplan-Meier Survival Analysis
ACC	0.0002	Kaplan-Meier Survival Analysis
BRCA	0.003	Kaplan-Meier Survival Analysis
ESCA	0.013	Kaplan-Meier Survival Analysis
KIRP	0.024	Kaplan-Meier Survival Analysis
KICH	0.0063	Kaplan-Meier Survival Analysis
UCEC	0.034	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000196591 (Gene tree)
Gene ID: 3066
Gene Symbol: HDAC2
Alias: RPD3|YAF1|KDAC2
Full Name: histone deacetylase 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 78,281 bases
Position: chr6:113,933,028-114,011,308
Accession: 4853
Summary: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28671300	Transcription-dependent association of HDAC2 with active chromatin.	J Cell Physiol	2018 Feb	Jahan S	doi: 10.1002/jcp.26078
23424244	The WD40-repeat proteins NFC101 and NFC102 regulate different aspects of maize development through chromatin modification.	Plant Cell	2013 Feb	Mascheretti I	doi: 10.1105/tpc.112.107219
14737171	The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.	Nature	2004 Jan 22	De Nadal E	-
25203139	Inactivation of histone deacetylase 1 (HDAC1) but not HDAC2 is required for the glucocorticoid-dependent CCAAT/enhancer-binding protein α (C/EBPα) expression and preadipocyte differentiation.	Endocrinology	2014 Dec	Kuzmochka C	doi: 10.1210/en.2014-1565
23558707	Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-kB activation in COPD.	Chest	2013 Aug	To M	doi: 10.1378/chest.12-2381.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000520170	HDAC2-207	690	-	-	- (aa)	-	-
ENST00000520895	HDAC2-209	551	-	ENSP00000428861	60 (aa)	-	E5RFI6
ENST00000523334	HDAC2-215	4810	-	-	- (aa)	-	-
ENST00000523628	HDAC2-216	549	-	ENSP00000427861	103 (aa)	-	E5RG37
ENST00000368632	HDAC2-201	2084	-	ENSP00000357621	458 (aa)	-	Q92769
ENST00000524334	HDAC2-217	570	-	ENSP00000428989	52 (aa)	-	E5RK19
ENST00000522371	HDAC2-213	502	-	ENSP00000428599	86 (aa)	-	E5RHE7
ENST00000521163	HDAC2-210	557	-	ENSP00000428024	109 (aa)	-	E5RFP9
ENST00000521233	HDAC2-211	733	-	-	- (aa)	-	-
ENST00000520746	HDAC2-208	497	-	-	- (aa)	-	-
ENST00000523240	HDAC2-214	557	-	ENSP00000429236	65 (aa)	-	E5RJ04
ENST00000518690	HDAC2-203	564	-	ENSP00000428653	71 (aa)	-	E5RGV4
ENST00000519065	HDAC2-205	9874	-	ENSP00000430432	488 (aa)	-	Q92769
ENST00000425835	HDAC2-202	553	-	ENSP00000417026	161 (aa)	-	H3BM24
ENST00000519108	HDAC2-206	2000	XM_017010799	ENSP00000430008	458 (aa)	XP_016866288	Q92769
ENST00000521610	HDAC2-212	580	-	ENSP00000429901	100 (aa)	-	E5RH52
ENST00000518756	HDAC2-204	826	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04213	Longevity regulating pathway - multiple species	KEGG
hsa04330	Notch signaling pathway	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa05016	Huntington disease	KEGG
hsa05034	Alcoholism	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05220	Chronic myeloid leukemia	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000196591	Erythrocyte Count	1.3300000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196591's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000118	histone deacetylase complex	21873635.	IBA	Component
GO:0000122	negative regulation of transcription by RNA polymerase II	19041327.19276356.	IMP	Process
GO:0000790	nuclear chromatin	16217013.	HDA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	16217013.	HDA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	16217013.	HDA	Function
GO:0001103	RNA polymerase II repressing transcription factor binding	22926524.	IPI	Function
GO:0001975	response to amphetamine	-	IEA	Process
GO:0003300	cardiac muscle hypertrophy	-	IEA	Process
GO:0003682	chromatin binding	-	ISS	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004407	histone deacetylase activity	21873635.	IBA	Function
GO:0004407	histone deacetylase activity	16642021.	IDA	Function
GO:0005515	protein binding	9150135.11062478.11259576.11641274.11739383.12140263.12176973.12670868.12711603.14752048.16254079.16464847.16595694.16919237.17245431.17314511.17318229.17827154.17956988.17984088.18451879.19182791.19343227.19433865.19497860.19505873.19703393.19805145.20195357.20398657.20651739.21258344.21549307.21914818.21965678.22416134.23752268.24970816.25150861.25241761.25314079.26028330.26221039.26496610.	IPI	Function
GO:0005634	nucleus	18347167.24970816.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	24970816.	IDA	Component
GO:0005737	cytoplasm	12711221.	TAS	Component
GO:0006338	chromatin remodeling	17827154.	IC	Process
GO:0006344	maintenance of chromatin silencing	19372552.	IMP	Process
GO:0007596	blood coagulation	-	TAS	Process
GO:0008134	transcription factor binding	17827154.	IPI	Function
GO:0008284	positive regulation of cell proliferation	18347167.	IMP	Process
GO:0009913	epidermal cell differentiation	21093383.	ISS	Process
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IEA	Process
GO:0010870	positive regulation of receptor biosynthetic process	18316616.	IMP	Process
GO:0010977	negative regulation of neuron projection development	18754010.	ISS	Process
GO:0016358	dendrite development	-	ISS	Process
GO:0016575	histone deacetylation	19372552.	IMP	Process
GO:0016580	Sin3 complex	14966270.17827154.	IDA	Component
GO:0016581	NuRD complex	17827154.19644445.22926524.	IDA	Component
GO:0019213	deacetylase activity	-	ISS	Function
GO:0019899	enzyme binding	11062478.11641274.	IPI	Function
GO:0031000	response to caffeine	-	IEA	Process
GO:0031072	heat shock protein binding	-	IEA	Function
GO:0031492	nucleosomal DNA binding	16217013.	HDA	Function
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	-	IEA	Function
GO:0032496	response to lipopolysaccharide	-	IEA	Process
GO:0032732	positive regulation of interleukin-1 production	-	IEA	Process
GO:0032760	positive regulation of tumor necrosis factor production	-	IEA	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0032967	positive regulation of collagen biosynthetic process	19041327.	IC	Process
GO:0032991	protein-containing complex	16217013.	HDA	Component
GO:0032991	protein-containing complex	28046085.	IDA	Component
GO:0033558	protein deacetylase activity	19041327.	IMP	Function
GO:0034605	cellular response to heat	-	IEA	Process
GO:0035094	response to nicotine	-	IEA	Process
GO:0035098	ESC/E(Z) complex	20075857.	IDA	Component
GO:0042220	response to cocaine	-	IEA	Process
GO:0042475	odontogenesis of dentin-containing tooth	21093383.	ISS	Process
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IEA	Process
GO:0042733	embryonic digit morphogenesis	21093383.	ISS	Process
GO:0042826	histone deacetylase binding	28046085.	IPI	Function
GO:0043044	ATP-dependent chromatin remodeling	16217013.	HDA	Process
GO:0043066	negative regulation of apoptotic process	21093383.	ISS	Process
GO:0043392	negative regulation of DNA binding	-	IEA	Process
GO:0043433	negative regulation of DNA-binding transcription factor activity	19041327.	IMP	Process
GO:0043565	sequence-specific DNA binding	19276356.	IDA	Function
GO:0045347	negative regulation of MHC class II biosynthetic process	19041327.	IC	Process
GO:0045862	positive regulation of proteolysis	19041327.	IMP	Process
GO:0045892	negative regulation of transcription, DNA-templated	19041327.	IC	Process
GO:0045892	negative regulation of transcription, DNA-templated	19276356.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	19041327.	IC	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	19041327.19372552.	IMP	Process
GO:0048149	behavioral response to ethanol	-	IEA	Process
GO:0048714	positive regulation of oligodendrocyte differentiation	-	IEA	Process
GO:0051059	NF-kappaB binding	17785205.	IPI	Function
GO:0055093	response to hyperoxia	-	IEA	Process
GO:0060789	hair follicle placode formation	21093383.	ISS	Process
GO:0061000	negative regulation of dendritic spine development	-	IEA	Process
GO:0061029	eyelid development in camera-type eye	21093383.	ISS	Process
GO:0061198	fungiform papilla formation	21093383.	ISS	Process
GO:0070301	cellular response to hydrogen peroxide	-	IEA	Process
GO:0070822	Sin3-type complex	21873635.	IBA	Component
GO:0070932	histone H3 deacetylation	21873635.	IBA	Process
GO:0070932	histone H3 deacetylation	-	ISS	Process
GO:0070933	histone H4 deacetylation	21873635.	IBA	Process
GO:0070933	histone H4 deacetylation	-	ISS	Process
GO:0071300	cellular response to retinoic acid	-	IEA	Process
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1902437	positive regulation of male mating behavior	-	IEA	Process
GO:1903351	cellular response to dopamine	-	IEA	Process
GO:1990841	promoter-specific chromatin binding	-	IEA	Function
GO:2000757	negative regulation of peptidyl-lysine acetylation	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.