EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
15665816Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1.Cell Death Differ2005 AprHuang BH-
23975430Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer.Oncogene2014 Jul 10Roy SSdoi: 10.1038/onc.2013.332
23440245A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.Blood2013 Apr 25Santoro Fdoi: 10.1182/blood-2012-10-461988
21143702Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.Cancer Sci2011 FebCampos Bdoi: 10.1111/j.1349-7006.2010.01792.x
19416910Genetic dissection of histone deacetylase requirement in tumor cells.Proc Natl Acad Sci U S A2009 May 12Haberland Mdoi: 10.1073/pnas.0903139106
17935135Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors.Int J Cancer2008 Jan 15Pluemsampant S-
25605253Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation.Oncotarget2015 Sep 22Seo SKdoi: 10.18632/oncotarget.3100.
21527555Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.Cancer Res2011 Jul 1Ramsey MRdoi: 10.1158/0008-5472.CAN-11-0046
20398369HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells.Mol Cancer2010 Apr 16Sch??ler Sdoi: 10.1186/1476-4598-9-80.
22641068Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.Gastroenterology2012 SepBuurman Rdoi: 10.1053/j.gastro.2012.05.033
26729194p21 and CK2 interaction-mediated HDAC2 phosphorylation modulates KLF4 acetylation to regulate bladder cancer cell proliferation.Tumour Biol2016 JunJia ZMdoi: 10.1007/s13277-015-4618-1
29333444MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer.Biomed Res Int2017Wei Jdoi: 10.1155/2017/5348490
18212746Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy.Br J Cancer2008 Feb 12Weichert Wdoi: 10.1038/sj.bjc.6604199
30250993Expression profiles of histone modification genes in gastric cancer progression.Mol Biol Rep2018 DecOrenay-Boyacioglu Sdoi: 10.1007/s11033-018-4389-z
19099586Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.BMC Cancer2008 Dec 19Fritzsche FRdoi: 10.1186/1471-2407-8-381.
23110995X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer.Radiat Oncol2012 Oct 31Han Ydoi: 10.1186/1748-717X-7-183.
24218540Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis.J Pharmacol Exp Ther2014 JanRavillah Ddoi: 10.1124/jpet.113.208645
18408217Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.J Biol Chem2008 Jun 13Ishdorj Gdoi: 10.1074/jbc.M710177200
23251689Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.PLoS One2012Wang Gdoi: 10.1371/journal.pone.0052095
17786334Expression profile of class I histone deacetylases in human cancer tissues.Oncol Rep2007 OctNakagawa M-
19724929Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models.Int J Oncol2009 OctBracker TU-
22492270HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.J Cell Biochem2012 JunJung KHdoi: 10.1002/jcb.24090.
23544610HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9.Clin Invest Med2013 Apr 1Wang F-
20190809Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression.Oncogene2010 May 27Li Pdoi: 10.1038/onc.2010.51
26683361The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.Oncotarget2016 Jan 26Huang Rdoi: 10.18632/oncotarget.6618.
20585871Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.Ann Surg Oncol2010 DecMutze Kdoi: 10.1245/s10434-010-1182-1
23926105Loss of epigenetic Kruppel-like factor 4 histone deacetylase (KLF-4-HDAC)-mediated transcriptional suppression is crucial in increasing vascular endothelial growth factor (VEGF) expression in breast cancer.J Biol Chem2013 Sep 20Ray Adoi: 10.1074/jbc.M113.481184
19912635High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo.BMC Cancer2009 Nov 13Lehmann Adoi: 10.1186/1471-2407-9-395.
24390319VPA inhibits renal cancer cell migration by targeting HDAC2 and down-regulating HIF-1α.Mol Biol Rep2014 MarYang FQdoi: 10.1007/s11033-013-2996-2
19383825Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.Clin Cancer Res2009 May 1Suzuki Jdoi: 10.1158/1078-0432.CCR-08-2319
22944197Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers.Urol Oncol2013 NovNiegisch Gdoi: 10.1016/j.urolonc.2012.06.015
26846508Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription.Cancer Chemother Pharmacol2016 MarYe Pdoi: 10.1007/s00280-016-2979-9
18347167Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo.Clin Cancer Res2008 Mar 15Weichert Wdoi: 10.1158/1078-0432.CCR-07-0990.
25942572Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers.Cell Cycle2015Bhaskara Sdoi: 10.1080/15384101.2015.1042634.
15144953Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.Cancer Cell2004 MayZhu P-
26352599HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population.Oncol Rep2015 NovLer SYdoi: 10.3892/or.2015.4263
28839465FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.Theranostics2017 Jul 22Zhu Wdoi: 10.7150/thno.18067

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr61139710795'UTRnovel0.19
BLCAchr6113944350SilentnovelA384A0.42
BLCAchr6113953306Missense_MutationNAE204K0.1
BLCAchr6113953377Missense_MutationnovelH180R0.08
BLCAchr6113943392Missense_MutationnovelR446K0.19
BRCAchr6113953393Missense_MutationNAD175N0.16
BRCAchr6113953414Missense_MutationNAH168Y0.18
BRCAchr6113941060Nonstop_Mutationnovel*489Rext*20.07
BRCAchr6113956047Nonsense_MutationnovelY153*0.56
CESCchr6113944295Missense_MutationnovelD403N0.09
CESCchr6113944296Frame_Shift_InsnovelD403Rfs*160.08
CESCchr6113970876Frame_Shift_Delrs759078191V12Sfs*200.37
CESCchr6113949209Missense_MutationnovelD231N0.15
CESCchr6113946070Missense_MutationnovelR307H0.07
CESCchr61139709435'UTRnovel0.44
CESCchr6113946106Frame_Shift_DelnovelP295Ifs*130.24
CESCchr6113953292SilentnovelG208G0.19
COADchr6113943504Nonsense_Mutationrs267600769R409*0.35
COADchr6113943500Missense_MutationNAA410V0.21
COADchr6113956131Nonsense_MutationNAR127*0.26
COADchr6113959917Frame_Shift_DelnovelM52Wfs*140.12
COADchr6113943354Frame_Shift_DelNAT459Qfs*470.4
COADchr6113956695Splice_SiteNAX95_splice0.26
COADchr6113946115Missense_MutationNAF292C0.21
GBMchr6113944331Missense_MutationNAH391D0.43
GBMchr6113945437Missense_MutationNAG339E0.43
HNSCchr6113949204SilentnovelG232G0.3
HNSCchr6113941720Frame_Shift_InsnovelT475Nfs*270.41
HNSCchr6113946071Missense_MutationnovelR307C0.55
HNSCchr6113946072SilentnovelI306I0.56
HNSCchr6113943473Missense_MutationnovelE419V0.18
KIRCchr6113958701Silentrs149797556L77L0.04
KIRPchr6113943481SilentNAA416A0.56
LAMLchr6113953393Missense_MutationNAD175N0.18
LGGchr6113956653Frame_Shift_DelNAF108*0.2
LGGchr6113958655Nonsense_MutationnovelQ93*0.37
LGGchr6113956115Frame_Shift_InsnovelM132Nfs*40.49
LIHCchr6113956114Missense_MutationnovelM132I0.66
LIHCchr6113943418Missense_MutationNAD437E0.37
LIHCchr6113943418Missense_MutationNAD437E0.16
LUADchr6113956151Missense_MutationnovelA120V0.19
LUADchr6113959945Missense_MutationNAL42F0.27
LUADchr6113959989Missense_MutationNAG28R0.05
LUADchr6113941061SilentNAP488P0.28
LUADchr6113956673Missense_MutationNAP102A0.11
LUADchr6113946119Frame_Shift_InsnovelT291Sfs*90.07
LUADchr6113958699Missense_MutationnovelR78L0.27
LUADchr6113949051Missense_MutationNAA257T0.24
LUADchr6113943363Missense_MutationNAD456N0.5
LUADchr6113958725SilentNAH69H0.12
LUSCchr6113956146Missense_MutationnovelA122S0.19
LUSCchr6113945439SilentnovelF338F0.18
LUSCchr6113956652Missense_MutationNAE109Q0.32
MESOchr61139710025'UTRrs7492151570.21
OVchr6113943491Splice_SitenovelX408_splice0.53
PCPGchr6113949062Missense_MutationNAY253C0.06
PRADchr6113946071Missense_MutationnovelR307S0.38
PRADchr6113956079Frame_Shift_InsnovelK144Rfs*120.47
PRADchr6113956080Nonsense_MutationnovelA143_K144ins*0.41
READchr6113945452Missense_MutationNAY334C0.31
READchr6113956629Silentrs373430125G116G0.17
READchr6113953323Nonsense_MutationNAS198*0.34
SKCMchr6113953403SilentnovelV171V0.11
SKCMchr6113953306Missense_MutationNAE204K0.07
SKCMchr6113956680Missense_MutationNAE99D0.4
SKCMchr6113959990SilentNAQ27Q0.36
STADchr6113943504Nonsense_Mutationrs267600769R409*0.46
STADchr6113946073Missense_MutationNAI306N0.06
STADchr6113953387Missense_MutationnovelD177N0.4
STADchr6113959931Missense_MutationnovelG47D0.14
STADchr6113945410Missense_MutationNAP348H0.07
UCECchr61139410293'UTRnovel0.33
UCECchr6113953315Missense_MutationNAK201E0.26
UCECchr6113944406Missense_MutationnovelR366C0.15
UCECchr6113943504Nonsense_Mutationrs267600769R409*0.44
UCECchr6113943354Frame_Shift_DelNAT459Qfs*470.39
UCECchr6113946032Missense_MutationnovelA320T0.32
UCECchr6113959961Missense_MutationnovelR37H0.48
UCECchr6113956039Missense_MutationnovelI157M0.05
UCECchr6113956057Missense_MutationNAF151L0.06
UCECchr6113956656SilentNAL107L0.23
UCECchr6113944386SilentnovelR372R0.56
UCECchr6113956670Missense_MutationnovelV103M0.5
UCECchr6113958706Missense_MutationnovelF76V0.29
UCECchr6113941763Missense_MutationnovelV461I0.4
UCECchr6113960010Missense_MutationnovelG21R0.29
UCECchr6113943354Frame_Shift_DelNAT459Qfs*470.45
UCECchr6113941088Splice_RegionnovelG479G0.14
UCECchr61139710975'UTRNA0.53
UCECchr6113943504Nonsense_Mutationrs267600769R409*0.37
UCECchr6113943354Frame_Shift_DelNAT459Qfs*470.42
UCECchr6113958746Silentrs776039140A62A0.43
UCECchr6113949082SilentnovelI246I0.41
UCECchr6113949076SilentNAK248K0.06
UCECchr6113959917Frame_Shift_DelnovelM52Wfs*140.5
UCECchr6113941738Missense_MutationnovelD469G0.1
UCECchr6113949243Frame_Shift_DelnovelG220Afs*100.2
UCECchr61139408653'UTRnovel0.21
UCECchr61139409943'UTRnovel0.11
UCECchr6113945367Missense_MutationNAK362N0.25
UCECchr6113943458Missense_MutationnovelS424F0.28
UCECchr6113945439SilentnovelF338F0.23
UCECchr6113953329Missense_MutationnovelT196M0.26
UCECchr6113959962Missense_MutationnovelR37C0.26
UCECchr61139408603'UTRnovel0.64
UCSchr6113943369Missense_MutationnovelT454A0.08

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.3753.4915e-05
DLBCDEL0.27080.00052595
ESCADEL0.2120.036953
GBMDEL0.21491.056e-05
KIRCDEL0.2337.439e-11
LGGDEL0.13840.0054594
LUADDEL0.41090.0021365
MESODEL0.43680.05642
PAADDEL0.36410.11274
SKCMDEL0.53681.5442e-06
STADDEL0.13610.0044196
THYMDEL0.13010.10691

Survival Analysis
CancerP-value Q-value
THYM0.017

Kaplan-Meier Survival Analysis

SARC0.00015

Kaplan-Meier Survival Analysis

MESO0.0039

Kaplan-Meier Survival Analysis

ACC0.0002

Kaplan-Meier Survival Analysis

BRCA0.003

Kaplan-Meier Survival Analysis

ESCA0.013

Kaplan-Meier Survival Analysis

KIRP0.024

Kaplan-Meier Survival Analysis

KICH0.0063

Kaplan-Meier Survival Analysis

UCEC0.034

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LUAD0.011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000196591 (Gene tree)
Gene ID
3066
Gene Symbol
HDAC2
Alias
RPD3|YAF1|KDAC2
Full Name
histone deacetylase 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
78,281 bases
Position
chr6:113,933,028-114,011,308
Accession
4853
RBP type
non-canonical RBP
Summary
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28671300Transcription-dependent association of HDAC2 with active chromatin.J Cell Physiol2018 FebJahan Sdoi: 10.1002/jcp.26078
23424244The WD40-repeat proteins NFC101 and NFC102 regulate different aspects of maize development through chromatin modification.Plant Cell2013 FebMascheretti Idoi: 10.1105/tpc.112.107219
14737171The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.Nature2004 Jan 22De Nadal E-
25203139Inactivation of histone deacetylase 1 (HDAC1) but not HDAC2 is required for the glucocorticoid-dependent CCAAT/enhancer-binding protein α (C/EBPα) expression and preadipocyte differentiation.Endocrinology2014 DecKuzmochka Cdoi: 10.1210/en.2014-1565
23558707Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-kB activation in COPD.Chest2013 AugTo Mdoi: 10.1378/chest.12-2381.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000520170HDAC2-207690--- (aa)--
ENST00000520895HDAC2-209551-ENSP0000042886160 (aa)-E5RFI6
ENST00000523334HDAC2-2154810--- (aa)--
ENST00000523628HDAC2-216549-ENSP00000427861103 (aa)-E5RG37
ENST00000368632HDAC2-2012084-ENSP00000357621458 (aa)-Q92769
ENST00000524334HDAC2-217570-ENSP0000042898952 (aa)-E5RK19
ENST00000522371HDAC2-213502-ENSP0000042859986 (aa)-E5RHE7
ENST00000521163HDAC2-210557-ENSP00000428024109 (aa)-E5RFP9
ENST00000521233HDAC2-211733--- (aa)--
ENST00000520746HDAC2-208497--- (aa)--
ENST00000523240HDAC2-214557-ENSP0000042923665 (aa)-E5RJ04
ENST00000518690HDAC2-203564-ENSP0000042865371 (aa)-E5RGV4
ENST00000519065HDAC2-2059874-ENSP00000430432488 (aa)-Q92769
ENST00000425835HDAC2-202553-ENSP00000417026161 (aa)-H3BM24
ENST00000519108HDAC2-2062000XM_017010799ENSP00000430008458 (aa)XP_016866288Q92769
ENST00000521610HDAC2-212580-ENSP00000429901100 (aa)-E5RH52
ENST00000518756HDAC2-204826--- (aa)--
Gene Model
Click here to download ENSG00000196591's gene model file
Pathways
Pathway IDPathway NameSource
hsa04110Cell cycleKEGG
hsa04213Longevity regulating pathway - multiple speciesKEGG
hsa04330Notch signaling pathwayKEGG
hsa04919Thyroid hormone signaling pathwayKEGG
hsa05016Huntington diseaseKEGG
hsa05034AlcoholismKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05169Epstein-Barr virus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05202Transcriptional misregulation in cancerKEGG
hsa05203Viral carcinogenesisKEGG
hsa05220Chronic myeloid leukemiaKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000196591Erythrocyte Count1.3300000E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196591's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000118histone deacetylase complex21873635.IBAComponent
GO:0000122negative regulation of transcription by RNA polymerase II19041327.19276356.IMPProcess
GO:0000790nuclear chromatin16217013.HDAComponent
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding16217013.HDAFunction
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding16217013.HDAFunction
GO:0001103RNA polymerase II repressing transcription factor binding22926524.IPIFunction
GO:0001975response to amphetamine-IEAProcess
GO:0003300cardiac muscle hypertrophy-IEAProcess
GO:0003682chromatin binding-ISSFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0004407histone deacetylase activity21873635.IBAFunction
GO:0004407histone deacetylase activity16642021.IDAFunction
GO:0005515protein binding9150135.11062478.11259576.11641274.11739383.12140263.12176973.12670868.12711603.14752048.16254079.16464847.16595694.16919237.17245431.17314511.17318229.17827154.17956988.17984088.18451879.19182791.19343227.19433865.19497860.19505873.19703393.19805145.20195357.20398657.20651739.21258344.21549307.21914818.21965678.22416134.23752268.24970816.25150861.25241761.25314079.26028330.26221039.26496610.IPIFunction
GO:0005634nucleus18347167.24970816.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm24970816.IDAComponent
GO:0005737cytoplasm12711221.TASComponent
GO:0006338chromatin remodeling17827154.ICProcess
GO:0006344maintenance of chromatin silencing19372552.IMPProcess
GO:0007596blood coagulation-TASProcess
GO:0008134transcription factor binding17827154.IPIFunction
GO:0008284positive regulation of cell proliferation18347167.IMPProcess
GO:0009913epidermal cell differentiation21093383.ISSProcess
GO:0010718positive regulation of epithelial to mesenchymal transition-IEAProcess
GO:0010870positive regulation of receptor biosynthetic process18316616.IMPProcess
GO:0010977negative regulation of neuron projection development18754010.ISSProcess
GO:0016358dendrite development-ISSProcess
GO:0016575histone deacetylation19372552.IMPProcess
GO:0016580Sin3 complex14966270.17827154.IDAComponent
GO:0016581NuRD complex17827154.19644445.22926524.IDAComponent
GO:0019213deacetylase activity-ISSFunction
GO:0019899enzyme binding11062478.11641274.IPIFunction
GO:0031000response to caffeine-IEAProcess
GO:0031072heat shock protein binding-IEAFunction
GO:0031492nucleosomal DNA binding16217013.HDAFunction
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)-IEAFunction
GO:0032496response to lipopolysaccharide-IEAProcess
GO:0032732positive regulation of interleukin-1 production-IEAProcess
GO:0032760positive regulation of tumor necrosis factor production-IEAProcess
GO:0032922circadian regulation of gene expression-ISSProcess
GO:0032967positive regulation of collagen biosynthetic process19041327.ICProcess
GO:0032991protein-containing complex16217013.HDAComponent
GO:0032991protein-containing complex28046085.IDAComponent
GO:0033558protein deacetylase activity19041327.IMPFunction
GO:0034605cellular response to heat-IEAProcess
GO:0035094response to nicotine-IEAProcess
GO:0035098ESC/E(Z) complex20075857.IDAComponent
GO:0042220response to cocaine-IEAProcess
GO:0042475odontogenesis of dentin-containing tooth21093383.ISSProcess
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IEAProcess
GO:0042733embryonic digit morphogenesis21093383.ISSProcess
GO:0042826histone deacetylase binding28046085.IPIFunction
GO:0043044ATP-dependent chromatin remodeling16217013.HDAProcess
GO:0043066negative regulation of apoptotic process21093383.ISSProcess
GO:0043392negative regulation of DNA binding-IEAProcess
GO:0043433negative regulation of DNA-binding transcription factor activity19041327.IMPProcess
GO:0043565sequence-specific DNA binding19276356.IDAFunction
GO:0045347negative regulation of MHC class II biosynthetic process19041327.ICProcess
GO:0045862positive regulation of proteolysis19041327.IMPProcess
GO:0045892negative regulation of transcription, DNA-templated19041327.ICProcess
GO:0045892negative regulation of transcription, DNA-templated19276356.IMPProcess
GO:0045893positive regulation of transcription, DNA-templated19041327.ICProcess
GO:0045944positive regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0045944positive regulation of transcription by RNA polymerase II19041327.19372552.IMPProcess
GO:0048149behavioral response to ethanol-IEAProcess
GO:0048714positive regulation of oligodendrocyte differentiation-IEAProcess
GO:0051059NF-kappaB binding17785205.IPIFunction
GO:0055093response to hyperoxia-IEAProcess
GO:0060789hair follicle placode formation21093383.ISSProcess
GO:0061000negative regulation of dendritic spine development-IEAProcess
GO:0061029eyelid development in camera-type eye21093383.ISSProcess
GO:0061198fungiform papilla formation21093383.ISSProcess
GO:0070301cellular response to hydrogen peroxide-IEAProcess
GO:0070822Sin3-type complex21873635.IBAComponent
GO:0070932histone H3 deacetylation21873635.IBAProcess
GO:0070932histone H3 deacetylation-ISSProcess
GO:0070933histone H4 deacetylation21873635.IBAProcess
GO:0070933histone H4 deacetylation-ISSProcess
GO:0071300cellular response to retinoic acid-IEAProcess
GO:0071560cellular response to transforming growth factor beta stimulus-IEAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
GO:1902437positive regulation of male mating behavior-IEAProcess
GO:1903351cellular response to dopamine-IEAProcess
GO:1990841promoter-specific chromatin binding-IEAFunction
GO:2000757negative regulation of peptidyl-lysine acetylation-IEAProcess
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