EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24272759	Expression of cyclophilin A in gastric adenocarcinoma patients and its inverse association with local relapses and distant metastasis.	Pathol Oncol Res	2014 Apr	Grigoryeva ES	doi: 10.1007/s12253-013-9718-x
24036847	Knockdown of cyclophilin A reverses paclitaxel resistance in human endometrial cancer cells via suppression of MAPK kinase pathways.	Cancer Chemother Pharmacol	2013 Nov	Li Z	doi: 10.1007/s00280-013-2285-8
17678621	Cyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal.	Biochem Biophys Res Commun	2007 Sep 28	Yang H	-
19584157	Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.	Clin Cancer Res	2009 Jul 15	Desmetz C	doi: 10.1158/1078-0432.CCR-08-3307
18829531	Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer.	Cancer Res	2008 Oct 1	Zheng J	doi: 10.1158/0008-5472.CAN-08-0639.
27468721	Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.	Tumour Biol	2016 Oct	Yamamoto T	-
25420107	Clinical significance of cyclophilin a expression in esophageal squamous cell carcinoma.	Genet Test Mol Biomarkers	2015 Apr	Feng MX	doi: 10.1089/gtmb.2014.0067
19865066	Cyclophilin A: potential functions and therapeutic target for human cancer.	Med Sci Monit	2009 Nov	Obchoei S	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BRCA	chr7	44801471	3'UTR	novel		0.18
BRCA	chr7	44799876	Splice_Region	novel		0.07
CESC	chr7	44799755	Silent	rs756262789	E81E	0.45
CESC	chr7	44799876	Splice_Region	novel		0.05
COAD	chr7	44799844	Missense_Mutation	novel	Q111R	0.13
HNSC	chr7	44801427	3'UTR	novel		0.29
KIRP	chr7	44799798	Missense_Mutation	NA	G96C	0.18
LUAD	chr7	44799264	Silent	rs142406481	V29V	0.31
LUSC	chr7	44799451	Missense_Mutation	NA	H54D	0.16
LUSC	chr7	44796791	Missense_Mutation	novel	E23Q	0.21
OV	chr7	44799474	Missense_Mutation	novel	M61I	0.04
PAAD	chr7	44801462	3'UTR	novel		0.15
PRAD	chr7	44799803	Frame_Shift_Del	novel	*L98Cfs35**	0.21
READ	chr7	44801416	Silent	novel	L164L	0.5
SKCM	chr7	44799851	Silent	NA	F113F	0.34
SKCM	chr7	44796717	5'UTR	novel		0.09
SKCM	chr7	44799400	Missense_Mutation	NA	R37C	0.16
SKCM	chr7	44799400	Missense_Mutation	NA	R37C	0.22
STAD	chr7	44796712	5'UTR	novel		0.22
UCEC	chr7	44801330	Missense_Mutation	novel	M136V	0.38
UCEC	chr7	44801417	Missense_Mutation	rs748726244	E165K	0.3
UCEC	chr7	44799481	Splice_Site	novel	X63_splice	0.38
UCEC	chr7	44801358	Missense_Mutation	novel	F145Y	0.1
UCEC	chr7	44801370	Missense_Mutation	novel	N149T	0.2
UCEC	chr7	44801417	Missense_Mutation	rs748726244	E165K	0.51
UCEC	chr7	44801678	3'UTR	novel		0.42
UCEC	chr7	44799791	Silent	novel	T93T	0.37
UCEC	chr7	44801364	Missense_Mutation	NA	S147F	0.48
UCEC	chr7	44801539	3'UTR	novel		0.22
UCEC	chr7	44796740	Missense_Mutation	novel	V6M	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
THYM	0.045	Kaplan-Meier Survival Analysis
KIRC	0.0027	Kaplan-Meier Survival Analysis
MESO	0.03	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.033	Kaplan-Meier Survival Analysis
ESCA	0.048	Kaplan-Meier Survival Analysis
KIRP	0.05	Kaplan-Meier Survival Analysis
PAAD	0.009	Kaplan-Meier Survival Analysis
KICH	0.045	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis
OV	0.047	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196262 (Gene tree)
Gene ID: 5478
Gene Symbol: PPIA
Alias: CYPA
Full Name: peptidylprolyl isomerase A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 27,929 bases
Position: chr7:44,796,636-44,824,564
Accession: 9253
RBP type: non-canonical RBP
Summary: This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21593166	Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.	J Virol	2011 Jul	Foster TL	doi: 10.1128/JVI.00393-11
22954804	Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.	Biochim Biophys Acta	2012 Dec	Weng L	doi: 10.1016/j.bbagen.2012.08.017
18203262	Growth hormone action in the developing neural retina: a proteomic analysis.	Proteomics	2008 Jan	Baudet ML	doi: 10.1002/pmic.200700952.
27126107	Symmetry-adapted digital modeling I. Axial symmetric proteins.	Acta Crystallogr A Found Adv	2016 May 1	Janner A	doi: 10.1107/S2053273316002746
12682639	Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies.	Leukemia	2003 Apr	Lossos IS	-
18981131	Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5.	J Immunol	2008 Nov 15	Gomez FJ	-
25031347	Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.	J Virol	2014 Oct	Chung HY	doi: 10.1128/JVI.01582-14
15543203	Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes.	Lab Invest	2005 Jan	de Kok JB	-
19937810	Selection of reference genes for real-time quantitative reverse transcription-polymerase chain reaction in hippocampal structure in a murine model of temporal lobe epilepsy with focal seizures.	J Neurosci Res	2010 Apr	Pernot F	doi: 10.1002/jnr.22282.
22802259	Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.	Antimicrob Agents Chemother	2012 Oct	Garcia-Rivera JA	doi: 10.1128/AAC.00919-12
21857920	Validation of endogenous control genes for gene expression studies on human ocular surface epithelium.	PLoS One	2011	Kulkarni B	doi: 10.1371/journal.pone.0022301
25573171	Identification of suitable reference genes for gene expression studies using quantitative polymerase chain reaction in lung cancer in vitro.	Mol Med Rep	2015 May	Ali H	doi: 10.3892/mmr.2015.3159
24089553	Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly.	J Virol	2013 Dec	Kovalev N	doi: 10.1128/JVI.02101-13
28134789	Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.	Int J Mol Sci	2017 Jan 27	Wang Y	doi: 10.3390/ijms18020263.
26393896	Identification of Valid Housekeeping Genes for Real-Time Quantitative PCR Analysis of Collapsed Lung Tissues of Neonatal Somatic Cell Nuclear Transfer-Derived Cattle.	Cell Reprogram	2015 Oct	Liu Y	doi: 10.1089/cell.2015.0024.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000620047	PPIA-210	827	-	ENSP00000479961	105 (aa)	-	P62937
ENST00000480603	PPIA-206	842	-	-	- (aa)	-	-
ENST00000468812	PPIA-204	2238	XM_024446808	ENSP00000419425	165 (aa)	XP_024302576	P62937
ENST00000415933	PPIA-202	863	-	ENSP00000394670	120 (aa)	-	F8WE65
ENST00000494484	PPIA-209	2149	-	-	- (aa)	-	-
ENST00000481437	PPIA-207	570	-	-	- (aa)	-	-
ENST00000489459	PPIA-208	907	-	ENSP00000427976	105 (aa)	-	P62937
ENST00000479021	PPIA-205	552	-	ENSP00000429251	58 (aa)	-	E5RIZ5
ENST00000355968	PPIA-201	818	XM_024446809	ENSP00000430817	105 (aa)	XP_024302577	P62937
ENST00000451562	PPIA-203	544	-	ENSP00000405975	121 (aa)	-	C9J5S7

Gene Model

Click here to download ENSG00000196262's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04217	Necroptosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196262	3-hydroxy-1-methylpropylmercapturic acid	8E-7	26053186
ENSG00000196262	Smoking	8E-7	26053186

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196262	rs185203327	7	44809836	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.6381	EFO_0004318\|EFO_0007015

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196262's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196262	PPIA	99	98.077	ENSMUSG00000071866	Ppia	100	96.341	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000413	protein peptidyl-prolyl isomerization	14993672.20676357.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	21873635.	IBA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	14993672.20676357.	IDA	Function
GO:0005515	protein binding	12218175.12357034.12730686.16169070.16273344.22174692.23152499.23935497.25416956.25556234.26656091.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005634	nucleus	16780588.	HDA	Component
GO:0005829	cytosol	16780588.	HDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006278	RNA-dependent DNA biosynthetic process	-	TAS	Process
GO:0006457	protein folding	2179953.2644542.	TAS	Process
GO:0016018	cyclosporin A binding	21873635.	IBA	Function
GO:0016018	cyclosporin A binding	12218175.12357034.20676357.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019058	viral life cycle	-	TAS	Process
GO:0019061	uncoating of virus	-	TAS	Process
GO:0019064	fusion of virus membrane with host plasma membrane	-	TAS	Process
GO:0019068	virion assembly	-	TAS	Process
GO:0019076	viral release from host cell	21711559.	TAS	Process
GO:0030260	entry into host cell	-	TAS	Process
GO:0031982	vesicle	19190083.	HDA	Component
GO:0032991	protein-containing complex	12218175.	IDA	Component
GO:0034389	lipid droplet organization	21711559.	IMP	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045069	regulation of viral genome replication	11250896.	IMP	Process
GO:0045069	regulation of viral genome replication	7590732.	TAS	Process
GO:0045070	positive regulation of viral genome replication	19932913.	IMP	Process
GO:0046790	virion binding	11250896.	NAS	Function
GO:0050714	positive regulation of protein secretion	21711559.	IMP	Process
GO:0050900	leukocyte migration	-	TAS	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051082	unfolded protein binding	2644542.	TAS	Function
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0070062	extracellular exosome	-	TAS	Component
GO:0075713	establishment of integrated proviral latency	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.