EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24272759Expression of cyclophilin A in gastric adenocarcinoma patients and its inverse association with local relapses and distant metastasis.Pathol Oncol Res2014 AprGrigoryeva ESdoi: 10.1007/s12253-013-9718-x
24036847Knockdown of cyclophilin A reverses paclitaxel resistance in human endometrial cancer cells via suppression of MAPK kinase pathways.Cancer Chemother Pharmacol2013 NovLi Zdoi: 10.1007/s00280-013-2285-8
17678621Cyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal.Biochem Biophys Res Commun2007 Sep 28Yang H-
19584157Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.Clin Cancer Res2009 Jul 15Desmetz Cdoi: 10.1158/1078-0432.CCR-08-3307
18829531Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer.Cancer Res2008 Oct 1Zheng Jdoi: 10.1158/0008-5472.CAN-08-0639.
27468721Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.Tumour Biol2016 OctYamamoto T-
25420107Clinical significance of cyclophilin a expression in esophageal squamous cell carcinoma.Genet Test Mol Biomarkers2015 AprFeng MXdoi: 10.1089/gtmb.2014.0067
19865066Cyclophilin A: potential functions and therapeutic target for human cancer.Med Sci Monit2009 NovObchoei S-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BRCAchr7448014713'UTRnovel0.18
BRCAchr744799876Splice_Regionnovel0.07
CESCchr744799755Silentrs756262789E81E0.45
CESCchr744799876Splice_Regionnovel0.05
COADchr744799844Missense_MutationnovelQ111R0.13
HNSCchr7448014273'UTRnovel0.29
KIRPchr744799798Missense_MutationNAG96C0.18
LUADchr744799264Silentrs142406481V29V0.31
LUSCchr744799451Missense_MutationNAH54D0.16
LUSCchr744796791Missense_MutationnovelE23Q0.21
OVchr744799474Missense_MutationnovelM61I0.04
PAADchr7448014623'UTRnovel0.15
PRADchr744799803Frame_Shift_DelnovelL98Cfs*350.21
READchr744801416SilentnovelL164L0.5
SKCMchr744799851SilentNAF113F0.34
SKCMchr7447967175'UTRnovel0.09
SKCMchr744799400Missense_MutationNAR37C0.16
SKCMchr744799400Missense_MutationNAR37C0.22
STADchr7447967125'UTRnovel0.22
UCECchr744801330Missense_MutationnovelM136V0.38
UCECchr744801417Missense_Mutationrs748726244E165K0.3
UCECchr744799481Splice_SitenovelX63_splice0.38
UCECchr744801358Missense_MutationnovelF145Y0.1
UCECchr744801370Missense_MutationnovelN149T0.2
UCECchr744801417Missense_Mutationrs748726244E165K0.51
UCECchr7448016783'UTRnovel0.42
UCECchr744799791SilentnovelT93T0.37
UCECchr744801364Missense_MutationNAS147F0.48
UCECchr7448015393'UTRnovel0.22
UCECchr744796740Missense_MutationnovelV6M0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
THCADEL00.27619

Survival Analysis
CancerP-value Q-value
THYM0.045

Kaplan-Meier Survival Analysis

KIRC0.0027

Kaplan-Meier Survival Analysis

MESO0.03

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

HNSC0.026

Kaplan-Meier Survival Analysis

SKCM0.033

Kaplan-Meier Survival Analysis

ESCA0.048

Kaplan-Meier Survival Analysis

KIRP0.05

Kaplan-Meier Survival Analysis

PAAD0.009

Kaplan-Meier Survival Analysis

KICH0.045

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

OV0.047

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000196262 (Gene tree)
Gene ID
5478
Gene Symbol
PPIA
Alias
CYPA
Full Name
peptidylprolyl isomerase A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
27,929 bases
Position
chr7:44,796,636-44,824,564
Accession
9253
RBP type
non-canonical RBP
Summary
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21593166Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.J Virol2011 JulFoster TLdoi: 10.1128/JVI.00393-11
22954804Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.Biochim Biophys Acta2012 DecWeng Ldoi: 10.1016/j.bbagen.2012.08.017
18203262Growth hormone action in the developing neural retina: a proteomic analysis.Proteomics2008 JanBaudet MLdoi: 10.1002/pmic.200700952.
27126107Symmetry-adapted digital modeling I. Axial symmetric proteins.Acta Crystallogr A Found Adv2016 May 1Janner Adoi: 10.1107/S2053273316002746
12682639Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies.Leukemia2003 AprLossos IS-
18981131Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5.J Immunol2008 Nov 15Gomez FJ-
25031347Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.J Virol2014 OctChung HYdoi: 10.1128/JVI.01582-14
15543203Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes.Lab Invest2005 Jande Kok JB-
19937810Selection of reference genes for real-time quantitative reverse transcription-polymerase chain reaction in hippocampal structure in a murine model of temporal lobe epilepsy with focal seizures.J Neurosci Res2010 AprPernot Fdoi: 10.1002/jnr.22282.
22802259Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.Antimicrob Agents Chemother2012 OctGarcia-Rivera JAdoi: 10.1128/AAC.00919-12
21857920Validation of endogenous control genes for gene expression studies on human ocular surface epithelium.PLoS One2011Kulkarni Bdoi: 10.1371/journal.pone.0022301
25573171Identification of suitable reference genes for gene expression studies using quantitative polymerase chain reaction in lung cancer in vitro.Mol Med Rep2015 MayAli Hdoi: 10.3892/mmr.2015.3159
24089553Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly.J Virol2013 DecKovalev Ndoi: 10.1128/JVI.02101-13
28134789Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.Int J Mol Sci2017 Jan 27Wang Ydoi: 10.3390/ijms18020263.
26393896Identification of Valid Housekeeping Genes for Real-Time Quantitative PCR Analysis of Collapsed Lung Tissues of Neonatal Somatic Cell Nuclear Transfer-Derived Cattle.Cell Reprogram2015 OctLiu Ydoi: 10.1089/cell.2015.0024.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000620047PPIA-210827-ENSP00000479961105 (aa)-P62937
ENST00000480603PPIA-206842--- (aa)--
ENST00000468812PPIA-2042238XM_024446808ENSP00000419425165 (aa)XP_024302576P62937
ENST00000415933PPIA-202863-ENSP00000394670120 (aa)-F8WE65
ENST00000494484PPIA-2092149--- (aa)--
ENST00000481437PPIA-207570--- (aa)--
ENST00000489459PPIA-208907-ENSP00000427976105 (aa)-P62937
ENST00000479021PPIA-205552-ENSP0000042925158 (aa)-E5RIZ5
ENST00000355968PPIA-201818XM_024446809ENSP00000430817105 (aa)XP_024302577P62937
ENST00000451562PPIA-203544-ENSP00000405975121 (aa)-C9J5S7
Gene Model
Click here to download ENSG00000196262's gene model file
Pathways
Pathway IDPathway NameSource
hsa04217NecroptosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG000001962623-hydroxy-1-methylpropylmercapturic acid8E-726053186
ENSG00000196262Smoking8E-726053186
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000196262rs185203327744809836?3-hydroxy-1-methylpropylmercapturic acid levels in smokers26053186[NR] unit decrease0.6381EFO_0004318|EFO_0007015
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196262's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000196262PPIA9998.077ENSMUSG00000071866Ppia10096.341Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000413protein peptidyl-prolyl isomerization14993672.20676357.IDAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003755peptidyl-prolyl cis-trans isomerase activity21873635.IBAFunction
GO:0003755peptidyl-prolyl cis-trans isomerase activity14993672.20676357.IDAFunction
GO:0005515protein binding12218175.12357034.12730686.16169070.16273344.22174692.23152499.23935497.25416956.25556234.26656091.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space16502470.HDAComponent
GO:0005634nucleus16780588.HDAComponent
GO:0005829cytosol16780588.HDAComponent
GO:0005829cytosol-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006278RNA-dependent DNA biosynthetic process-TASProcess
GO:0006457protein folding2179953.2644542.TASProcess
GO:0016018cyclosporin A binding21873635.IBAFunction
GO:0016018cyclosporin A binding12218175.12357034.20676357.IDAFunction
GO:0016020membrane19946888.HDAComponent
GO:0019058viral life cycle-TASProcess
GO:0019061uncoating of virus-TASProcess
GO:0019064fusion of virus membrane with host plasma membrane-TASProcess
GO:0019068virion assembly-TASProcess
GO:0019076viral release from host cell21711559.TASProcess
GO:0030260entry into host cell-TASProcess
GO:0031982vesicle19190083.HDAComponent
GO:0032991protein-containing complex12218175.IDAComponent
GO:0034389lipid droplet organization21711559.IMPProcess
GO:0034774secretory granule lumen-TASComponent
GO:0035722interleukin-12-mediated signaling pathway-TASProcess
GO:0042026protein refolding21873635.IBAProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0045069regulation of viral genome replication11250896.IMPProcess
GO:0045069regulation of viral genome replication7590732.TASProcess
GO:0045070positive regulation of viral genome replication19932913.IMPProcess
GO:0046790virion binding11250896.NASFunction
GO:0050714positive regulation of protein secretion21711559.IMPProcess
GO:0050900leukocyte migration-TASProcess
GO:0051082unfolded protein binding21873635.IBAFunction
GO:0051082unfolded protein binding2644542.TASFunction
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0070062extracellular exosome-TASComponent
GO:0075713establishment of integrated proviral latency-TASProcess
GO:1904813ficolin-1-rich granule lumen-TASComponent
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