EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28209128miR-296 inhibits the metastasis and epithelial-mesenchymal transition of colorectal cancer by targeting S100A4.BMC Cancer2017 Feb 16He Zdoi: 10.1186/s12885-017-3121-z.
16865243Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer.Oncol Rep2006 SepOida Y-
18246798[Inverse correlation of S100A4 and E-cad protein expression and their clinical significance in non-small cell lung cancer].Zhonghua Zhong Liu Za Zhi2007 SepQi RX-
20019188S100A4 and metastasis: a small actor playing many roles.Am J Pathol2010 FebBoye Kdoi: 10.2353/ajpath.2010.090526
20712050Expression of protein S100A4 is a predictor of recurrence in colorectal cancer.World J Gastroenterol2010 Aug 21Kwak JM-
17565747Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer.Int J Cancer2007 Oct 1Cabez??n T-
19194111Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites.Tumour Biol2009Maelandsmo GMdoi: 10.1159/000199447
27193714Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells.Dokl Biochem Biophys2016 MarPortseva TNdoi: 10.1134/S1607672916020125
21837681Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer.J Surg Oncol2012 FebKang YGdoi: 10.1002/jso.22070
22200787Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells.Oncol Rep2012 AprHuang Ldoi: 10.3892/or.2011.1598
21924240Copper-mediated cross-linking of S100A4, but not of S100A2, results in proinflammatory effects in melanoma cells.Biochem Biophys Res Commun2011 Sep 30Haase-Kohn Cdoi: 10.1016/j.bbrc.2011.08.132
20332215Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts.Mol Cancer Res2010 AprRadestock Ydoi: 10.1158/1541-7786.MCR-09-0307
15579771Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma.J Clin Endocrinol Metab2004 DecZou M-
19945782Short hairpin RNA-mediated inhibition of S100A4 promotes apoptosis and suppresses proliferation of BGC823 gastric cancer cells in vitro and in vivo.Cancer Lett2010 Jun 1Hua Jdoi: 10.1016/j.canlet.2009.11.007
12439718Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies.Br J Cancer2002 Nov 18Pedersen KB-
11994292Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.J Biol Chem2002 Jul 19Endo H-
24240114Neutrophils promote the malignant glioma phenotype through S100A4.Clin Cancer Res2014 Jan 1Liang Jdoi: 10.1158/1078-0432.CCR-13-1279
15781852Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.Proc Natl Acad Sci U S A2005 Mar 29Fernandez-Fernandez MR-
15852272S100A4 antisense oligodeoxynucleotide suppresses invasive potential of neuroblastoma cells.J Pediatr Surg2005 AprGao XN-
23929008Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth.Angiogenesis2014 JanOchiya Tdoi: 10.1007/s10456-013-9372-7
24378831Human osteosarcoma cells respond to sorafenib chemotherapy by downregulation of the tumor progression factors S100A4, CXCR4 and the oncogene FOS.Oncol Rep2014 MarWalter Idoi: 10.3892/or.2013.2954
12445462Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton.Biochim Biophys Acta2002 Nov 4Belot N-
24215866Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties.Cancer Lett2014 Mar 1Bettum IJdoi: 10.1016/j.canlet.2013.10.036
24968947Combined expression of S100A4 and Annexin A2 predicts disease progression and overall survival in patients with urothelial carcinoma.Urol Oncol2014 AugZhang Qdoi: 10.1016/j.urolonc.2014.02.009
26903691Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis.Dis Markers2016Huang Sdoi: 10.1155/2016/8137378
24217649The E-F hand calcium-binding protein S100A4 regulates the proliferation, survival and differentiation potential of human osteosarcoma cells.Cell Physiol Biochem2013Chen Xdoi: 10.1159/000354508
17504119Metastasis-associated protein S100A4: spotlight on its role in cell migration.Curr Cancer Drug Targets2007 MayTarabykina S-
19703228Methylation-associated silencing of S100A4 expression in human epidermal cancers.Exp Dermatol2009 OctLi Ydoi: 10.1111/j.1600-0625.2009.00922.x
28423501Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression.Oncotarget2017 Mar 28Mudduluru Gdoi: 10.18632/oncotarget.15499.
29578167Overexpression of S100A4 protein may be associated with the development and progression of pancreatic cancer.J Cancer Res Ther2018Zhou Ydoi: 10.4103/0973-1482.172582.
19808905Integrin (alpha6beta4) signals through Src to increase expression of S100A4, a metastasis-promoting factor: implications for cancer cell invasion.Mol Cancer Res2009 OctKim THdoi: 10.1158/1541-7786.MCR-09-0102
21352421S100A4 protects gastric cancer cells from anoikis through regulation of αv and α5 integrin.Cancer Sci2011 MayShen Wdoi: 10.1111/j.1349-7006.2011.01915.x
26409452S100A4 participates in epithelial-mesenchymal transition in breast cancer via targeting MMP2.Tumour Biol2016 MarXu Hdoi: 10.1007/s13277-015-3709-3
23026527S100A4 siRNA inhibits human pancreatic cancer cell invasion in vitro.Biomed Environ Sci2012 AugLi Ndoi: 10.3967/0895-3988.2012.04.012.
23900547S100A4 mRNA expression level is a predictor of radioresistance of pancreatic cancer cells.Oncol Rep2013 OctKozono Sdoi: 10.3892/or.2013.2636
27109209S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation.Oncol Rep2016 JunHua Tdoi: 10.3892/or.2016.4760
23546393RPS12-specific shRNA inhibits the proliferation, migration of BGC823 gastric cancer cells with S100A4 as a downstream effector.Int J Oncol2013 MayChen Ddoi: 10.3892/ijo.2013.1872
17550972CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway.J Cell Sci2007 Jun 15Chen PS-
22287060Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene.Int J Cancer2012 Oct 15Horiuchi Adoi: 10.1002/ijc.27448
23832737RNA interference suppression of A100A4 reduces the growth and metastatic phenotype of human renal cancer cells via NF-kB-dependent MMP-2 and bcl-2 pathway.Eur Rev Med Pharmacol Sci2013 JunYang XC-
22740693The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.J Biol Chem2012 Aug 31Liu Sdoi: 10.1074/jbc.M112.343947
23316018Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: role of the S100A4-miR155-SOCS1-MMP9 axis.Hepatology2013 JunYan XLdoi: 10.1002/hep.26257
26274343PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression.J Clin Endocrinol Metab2015 OctJendrzejewski Jdoi: 10.1210/jc.2015-2247
22878175Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.Oncotarget2012 AugDahlmann M-
23149742The metastasis-promoting S100A4 protein confers neuroprotection in brain injury.Nat Commun2012Dmytriyeva Odoi: 10.1038/ncomms2202.
19956863Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery.Oncol Rep2010 JanWang HY-
24174222S100A4 is upregulated via the binding of c-Myb in methylation-free laryngeal cancer cells.Oncol Rep2014 JanLiu Jdoi: 10.3892/or.2013.2824
23851436The expression of S100A4 in human pancreatic cancer is associated with invasion.Pancreas2013 AugTsukamoto Ndoi: 10.1097/MPA.0b013e31828804e7.
23162804S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13.Acta Biochim Pol2012Wang L-
20719498Nuclear S100A4 is a novel prognostic marker in colorectal cancer.Eur J Cancer2010 NovBoye Kdoi: 10.1016/j.ejca.2010.07.013
19653048S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma.J Gastrointest Surg2009 OctIkenaga Ndoi: 10.1007/s11605-009-0978-4
26741489Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4.PLoS One2016 Jan 7Grottke Adoi: 10.1371/journal.pone.0146370
27193724The level of the Phf10 protein, a PBAF chromatin-remodeling complex subunit, correlates with the Mts1/S100A4 expression in human cancer cell lines.Dokl Biochem Biophys2016 MarSoshnikova NVdoi: 10.1134/S1607672916020228
25252758LIM and SH3 protein 1 induces TGFβ-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression.Clin Cancer Res2014 Nov 15Wang Hdoi: 10.1158/1078-0432.CCR-14-0485
20093727Wnt up your mind - intervention strategies for S100A4-induced metastasis in colon cancer.Gen Physiol Biophys2009Sack U-
19059703Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy.Cancer Lett2009 Jul 18Sherbet GVdoi: 10.1016/j.canlet.2008.10.037
26897964EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation, Migration of Gastric Cancer Cells.Hepatogastroenterology2015 MayLiu S-
21195708The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis.Dev Biol2011 Apr 15Andersen Kdoi: 10.1016/j.ydbio.2010.12.033
19820999High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer.Ann Surg Oncol2010 JanWang YYdoi: 10.1245/s10434-009-0722-z
21169409The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers.Cancer Res2011 Mar 1Lo JFdoi: 10.1158/0008-5472.CAN-10-2350
24732359S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility.Biochem Biophys Res Commun2014 May 9Chen Ndoi: 10.1016/j.bbrc.2014.04.025
19506550S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling.Lab Invest2009 AugXie Rdoi: 10.1038/labinvest.2009.52
24957789Prognostic significance of heme oxygenase-1, S100 calcium-binding protein A4, and syndecan-1 expression in primary non-muscle-invasive bladder cancer.Hum Pathol2014 SepKim JHdoi: 10.1016/j.humpath.2014.04.020
21218086S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer.World J Gastroenterol2011 Jan 7Huang LYdoi: 10.3748/wjg.v17.i1.69.
26722531Evaluation of S100A4 mRNA in EUS-FNA specimens for the assessment of chemosensitivity to gemcitabine from patients with unresectable pancreatic cancer.Int J Clin Exp Pathol2015 Oct 1Ma G-
19513503Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer.Oncol Rep2009 JulKim JH-
25217321Increased expression levels of S100A4 associated with hypoxia-induced invasion and metastasis in esophageal squamous cell cancer.Tumour Biol2014 DecXuan Xdoi: 10.1007/s13277-014-2573-x
25511023S100A4 expression and prognosis of gastric cancer: a meta-analysis.Genet Mol Res2014 Dec 12Wang Ydoi: 10.4238/2014.December.12.1.
12532418Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression.Int J Cancer2003 Mar 10Kohya N-
27770373Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases.Clin Exp Metastasis2017 JanG??mez-Contreras Pdoi: 10.1007/s10585-016-9827-5
16489073Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer.Clin Cancer Res2006 Feb 15de Silva Rudland S-
20515499Overexpression of S100A4 in human cancer cell lines resistant to methotrexate.BMC Cancer2010 Jun 1Menc??a Ndoi: 10.1186/1471-2407-10-250.
17638890S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer.Cancer Res2007 Jul 15Mahon PC-
18350635Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer.World J Gastroenterol2008 Mar 28Ai KX-
24952599RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis.Oncotarget2014 May 30Dahlmann M-
26497012S100A4 interacts with mutant p53 and affects gastric cancer MKN1 cell autophagy and differentiation.Int J Oncol2015 DecShen Wdoi: 10.3892/ijo.2015.3209
23085231S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells.Biochem Biophys Res Commun2012 Dec 14Sekine Hdoi: 10.1016/j.bbrc.2012.10.048
28058579Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer.Breast Cancer Res Treat2017 FebEgeland EVdoi: 10.1007/s10549-016-4096-1
27793047Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers.Oncotarget2016 Nov 29Cheng LHdoi: 10.18632/oncotarget.12935.
28675500FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.Cell Biol Int2017 OctGuo Jdoi: 10.1002/cbin.10816
29342841miR-3189-3p Mimics Enhance the Effects of S100A4 siRNA on the Inhibition of Proliferation and Migration of Gastric Cancer Cells by Targeting CFL2.Int J Mol Sci2018 Jan 13Bian Ydoi: 10.3390/ijms19010236.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
COADchr1153544786Nonsense_MutationnovelC3*0.31
COADchr11535436323'UTRnovel0.4
COADchr1153543871Missense_MutationnovelN65S0.08
COADchr1153543788Missense_MutationNAF93V0.35
ESCAchr1153543914Missense_MutationnovelD51H0.17
GBMchr1153543837SilentnovelC76C0.15
GBMchr1153543858Missense_MutationnovelE69D0.46
HNSCchr1153543765Missense_MutationnovelK100N0.23
HNSCchr1153543924Splice_SitenovelX48_splice0.2
HNSCchr1153543821Missense_MutationnovelI82V0.28
KICHchr1153543818Missense_MutationNAA83T0.39
LGGchr1153543916Missense_MutationnovelT50I0.04
LIHCchr1153544667Missense_MutationNAP43H0.3
LUADchr1153543781Missense_MutationnovelD95G0.48
LUADchr1153544807Splice_Regionnovel0.08
LUSCchr11535436833'UTRnovel0.38
OVchr11535437113'UTRnovel0.56
OVchr1153543855SilentnovelV70V0.08
PRADchr1153543861Silentrs111468775N68N0.11
SARCchr11535437143'UTRnovel0.14
SKCMchr11535437333'UTRrs5502136720.41
SKCMchr11535437143'UTRnovel0.12
SKCMchr11535436283'UTRnovel0.33
SKCMchr11535437533'UTRnovel0.18
SKCMchr1153544657SilentnovelL46L0.43
UCECchr11535436813'UTRnovel0.27
UCECchr1153544697Missense_MutationnovelE33G0.29
UCECchr1153543818Missense_MutationNAA83T0.46
UCECchr1153543802Missense_MutationnovelE88A0.35
UCECchr1153543765Missense_MutationnovelK100N0.28
UCECchr1153543803Missense_Mutationrs368160023E88K0.12
UCECchr1153543818Missense_MutationNAA83T0.35
UCECchr1153543860Missense_MutationnovelE69K0.33
UCECchr1153543830Missense_MutationnovelL79M0.11

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.14440.11282
CESCAMP0.48473.2002e-05
DLBCDEL0.04170.0017831
ESCAAMP0.41850.0022446
KIRCAMP0.09280.059566
LUSCAMP0.43111.6618e-06
PAADAMP0.22280.085665
PCPGAMP0.16050.00029562
READAMP0.26670.025154
SARCAMP0.35024.3422e-08
SKCMAMP0.48779.6912e-06
TGCTAMP0.35330.088103

Survival Analysis
CancerP-value Q-value
SARC0.032

Kaplan-Meier Survival Analysis

HNSC0.00043

Kaplan-Meier Survival Analysis

SKCM0.022

Kaplan-Meier Survival Analysis

PRAD0.016

Kaplan-Meier Survival Analysis

PAAD0.0085

Kaplan-Meier Survival Analysis

BLCA0.035

Kaplan-Meier Survival Analysis

READ0.022

Kaplan-Meier Survival Analysis

LAML0.0001

Kaplan-Meier Survival Analysis

GBM0.024

Kaplan-Meier Survival Analysis

UVM0.0002

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000196154 (Gene tree)
Gene ID
6275
Gene Symbol
S100A4
Alias
P9KA|18A2|PEL98|42A|FSP1|MTS1|CAPL
Full Name
S100 calcium binding protein A4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
6,524 bases
Position
chr1:153,543,613-153,550,136
Accession
10494
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19790156Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways.Liver Transpl2009 OctBridle KRdoi: 10.1002/lt.21804.
9018119Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells.Oncogene1997 Jan 23Takenaga K-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000354332S100A4-201566-ENSP00000346294101 (aa)-P26447
ENST00000368714S100A4-202531-ENSP00000357703101 (aa)-P26447
ENST00000368715S100A4-203573-ENSP00000357704101 (aa)-P26447
ENST00000368716S100A4-204600-ENSP00000357705101 (aa)-P26447
ENST00000481009S100A4-206755--- (aa)--
ENST00000468373S100A4-205537--- (aa)--
Gene Model
Click here to download ENSG00000196154's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000196154rs1389576161153544617GPulse pressure30578418[0.16-0.34] mmHg increase0.2473EFO_0005763
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196154's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001837epithelial to mesenchymal transition14679171.TASProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0003779actin binding-IEAFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding14640694.15479433.16189514.19740107.20421509.20591429.21516116.22483112.23752197.25416956.26496610.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005615extracellular space22664934.23580065.HDAComponent
GO:0005634nucleus12118070.15033494.IDAComponent
GO:0042802identical protein binding20421509.22483112.IPIFunction
GO:0043005neuron projection-IEAComponent
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling15033494.IDAProcess
GO:0046914transition metal ion binding-IEAFunction
GO:0048306calcium-dependent protein binding-IEAFunction
GO:0048471perinuclear region of cytoplasm15033494.IDAComponent
GO:0050786RAGE receptor binding15033494.IPIFunction
GO:0062023collagen-containing extracellular matrix25037231.HDAComponent
GO:0070062extracellular exosome19056867.HDAComponent
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