EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18388483Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility.J Microbiol Biotechnol2008 MarKim Y-
28152297DDX53 Promotes Cancer Stem Cell-Like Properties and Autophagy.Mol Cells2017 JanKim Hdoi: 10.14348/molcells.2017.2258
26883907Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs.Mol Cells2016 MarKim Hdoi: 10.14348/molcells.2016.2244
17028776Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK).Biotechnol Lett2006 DecShim H-
26863629miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2.Oncotarget2016 Mar 1Kim Ydoi: 10.18632/oncotarget.7185.
26912082miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs.Mol Cells2016 Apr 30Park Ddoi: 10.14348/molcells.2016.2242
12849980Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma.Biochem Biophys Res Commun2003 Jul 18Cho B-
28535666DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to SOX-2.Mol Cells2017 May 31Kim Ydoi: 10.14348/molcells.2017.0001

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchrX23000733Missense_MutationNAA226T0.29
ACCchrX23000983Missense_MutationnovelA309D0.23KH_1
BLCAchrX23000955Missense_MutationNAL300I0.07KH_1
BLCAchrX23001405Missense_MutationNAE450Q0.06
BLCAchrX23001181Missense_MutationnovelI375T0.15KH_1
BRCAchrX23000541Missense_MutationNAE162K0.19
BRCAchrX23001656SilentnovelL533L0.1
BRCAchrX23001249Missense_Mutationrs769123385R398C0.24KH_1
BRCAchrX23000611Missense_MutationnovelT185I0.06
BRCAchrX23000208Missense_MutationnovelL51F0.07
BRCAchrX23001701SilentNAI548I0.16
BRCAchrX23001637Missense_MutationNAV527G0.44
BRCAchrX23000078Missense_MutationnovelE7D0.1
BRCAchrX23000537Silentrs749049454V160V0.08
CESCchrX23001045Missense_MutationNAY330H0.4KH_1
CESCchrX23001041Silentrs748256605C328C0.26
CESCchrX23001405Missense_MutationNAE450Q0.41
COADchrX23000287Missense_MutationNAS77L0.38
COADchrX23000589Missense_MutationnovelF178V0.06
COADchrX23001512Silentrs373240695S485S0.18
COADchrX23001250Missense_Mutationrs368434907R398H0.07KH_1
COADchrX230019643'UTRnovel0.45
COADchrX23000315Silentrs778444531N86N0.1
COADchrX23001830SilentNAQ591Q0.31
COADchrX23001579SilentNAR508R0.15
COADchrX23000304Missense_MutationNAQ83E0.22
COADchrX23000089Missense_MutationNAA11V0.14
COADchrX23000271Missense_MutationnovelK72E0.07
COADchrX23001351Missense_MutationNAN432D0.54
GBMchrX23001603Missense_Mutationrs751629687G516R0.06
GBMchrX23000475Frame_Shift_InsnovelR140Mfs*30.04
GBMchrX23001335Missense_MutationNAM426I0.27
HNSCchrX23000681Missense_MutationnovelL208F0.55
HNSCchrX23001694Missense_MutationnovelR546K0.43
HNSCchrX23001220Missense_MutationnovelP388L0.49KH_1
HNSCchrX23000994Nonsense_MutationnovelE313*0.35KH_1
KIRCchrX23001704Silentrs768020057D549D0.16
KIRCchrX230019823'UTRnovel0.12
KIRPchrX23000991Missense_Mutationrs756147094V312M0.56KH_1
LAMLchrX23000179Missense_MutationNAP41L0.4
LGGchrX23000165SilentnovelF36F0.34
LIHCchrX23000315Silentrs778444531N86N0.8
LIHCchrX230020183'UTRnovel0.89
LIHCchrX23001455SilentnovelP466P0.05
LIHCchrX23001510Missense_MutationNAS485G0.92
LUADchrX23001895Missense_MutationNAR613I0.35
LUADchrX23001593SilentNAD512D0.33
LUADchrX23000255Nonsense_MutationnovelY66*0.11
LUADchrX23000206Missense_MutationNAP50Q0.41
LUADchrX23000947Missense_MutationNAP297H0.34KH_1
LUADchrX23001306Missense_MutationnovelL417I0.2
LUADchrX23001643Missense_MutationNAR529Q0.05
LUADchrX23001356SilentNAL433L0.36
LUADchrX23000419Nonsense_MutationnovelS121*0.21
LUADchrX23000411SilentNAS118S0.32
LUSCchrX23001576Missense_MutationnovelE507K0.69
LUSCchrX23001271Missense_MutationnovelM405K0.36KH_1
LUSCchrX23001052Missense_MutationnovelG332V0.59KH_1
LUSCchrX23000314Missense_MutationNAN86S0.28
LUSCchrX23000270Missense_MutationNAI71M0.09
LUSCchrX23000551Missense_MutationNAK165R0.24
LUSCchrX23001861Missense_MutationNAE602K0.36
LUSCchrX23001420Missense_MutationnovelA455T0.1
LUSCchrX23001815SilentNAL586L0.18
LUSCchrX23001854SilentNAV599V0.23
LUSCchrX23000421Missense_MutationNAE122Q0.08
LUSCchrX23001784Missense_MutationNAS576L0.58
LUSCchrX23000414Nonsense_MutationnovelY119*0.33
LUSCchrX23000554Missense_MutationnovelR166I0.45
LUSCchrX23000951SilentNAG298G0.4
OVchrX23000512Frame_Shift_InsnovelN152Kfs*60.09
OVchrX23000991Missense_Mutationrs756147094V312M0.64KH_1
OVchrX23001585Missense_MutationnovelV510L0.09
OVchrX23000850Missense_MutationnovelV265F0.1KH_1
OVchrX23000449Missense_MutationnovelQ131P0.11
PAADchrX23001942Missense_MutationnovelF629V0.2
READchrX23001785Silentrs768469586S576S0.47
READchrX23000586Frame_Shift_InsNAN177Ifs*140.28
READchrX23001078Missense_MutationnovelD341Y0.07KH_1
SARCchrX230020803'UTRnovel0.06
SKCMchrX23000380Missense_MutationNAA108G0.13
SKCMchrX23001055Missense_Mutationrs778044990R333K0.11KH_1
SKCMchrX23000112Missense_MutationNAG19R0.38
SKCMchrX23000960SilentnovelV301V0.33
SKCMchrX23001650SilentNAL531L0.23
SKCMchrX23000358Missense_MutationNAM101L0.58
SKCMchrX23000916Nonsense_MutationNAQ287*0.51KH_1
SKCMchrX23001640Missense_MutationNAS528F0.56
SKCMchrX23001933Missense_MutationNAE626K0.52
SKCMchrX23000196Missense_MutationNAR47C0.34
SKCMchrX23001784Missense_MutationNAS576L0.19
SKCMchrX23000355Missense_MutationNAE100K0.29
SKCMchrX23000652Missense_MutationNAE199K0.3
SKCMchrX23001784Missense_MutationNAS576L0.62
SKCMchrX23000652Missense_MutationNAE199K0.32
SKCMchrX23000195SilentNAS46S0.88
SKCMchrX23000467Missense_MutationNAN137I0.8
SKCMchrX23000360Missense_MutationNAM101I0.11
SKCMchrX23001695SilentnovelR546R0.81
SKCMchrX23000775Missense_MutationNAV240I0.53
SKCMchrX23000410Missense_Mutationrs760082872S118N0.54
SKCMchrX23001221SilentNAP388P0.83
SKCMchrX23001101Silentrs529875384I348I0.4
SKCMchrX23001067Missense_Mutationrs368652147G337E0.92KH_1
SKCMchrX23000175Missense_MutationnovelG40R0.9
STADchrX23000662Missense_MutationNAN202S0.39
STADchrX23001513Missense_Mutationrs149709546D486N0.68
STADchrX23000410Missense_Mutationrs760082872S118N0.09
STADchrX23001872Missense_MutationNAK605N0.09
STADchrX23000089Missense_MutationNAA11V0.22
STADchrX23000303Missense_MutationNAI82M0.45
STADchrX23000157Missense_MutationnovelG34C0.58
UCECchrX23001794SilentnovelA579A0.69
UCECchrX23001801Missense_MutationNAL582M0.43
UCECchrX23000501Missense_MutationNAE148D0.28
UCECchrX23000874Missense_MutationNAT273A0.25KH_1
UCECchrX23001712Missense_MutationnovelV552A0.08
UCECchrX23001923Missense_MutationnovelQ622H0.21
UCECchrX23000227Missense_MutationNAN57S0.3
UCECchrX23001654Missense_MutationNAL533F0.36
UCECchrX23000662Missense_MutationNAN202S0.37
UCECchrX23001300Missense_Mutationrs754046377R415C0.48KH_1
UCECchrX23000131Missense_Mutationrs754998919R25M0.1
UCECchrX23001320Nonsense_MutationnovelY421*0.33
UCECchrX23000180SilentNAP41P0.33
UCECchrX23000142Missense_MutationnovelG29C0.43
UCECchrX23000914Missense_MutationNAS286F0.38KH_1
UCECchrX23000894Frame_Shift_InsnovelG280Rfs*110.12KH_1
UCECchrX23001563SilentNAE502E0.17
UCECchrX23000377Missense_MutationNAA107V0.39
UCECchrX23000904Frame_Shift_InsnovelH283Pfs*190.05KH_1
UCECchrX230000125'UTRnovel0.22
UCECchrX23000174Missense_MutationnovelQ39H0.08
UCECchrX230019953'UTRnovel0.3
UCECchrX230000315'UTRnovel0.33
UCECchrX23001704Silentrs768020057D549D0.45
UCECchrX23000862Missense_MutationnovelG269R0.38KH_1
UCECchrX23000476Missense_MutationnovelR140I0.48
UCECchrX23000841Missense_MutationnovelL262I0.43KH_1
UCECchrX23000546Silentrs200945232C163C0.2
UCECchrX23001299SilentnovelV414V0.27
UCECchrX23001124Missense_MutationnovelL356P0.35KH_1
UCECchrX23000091Nonsense_MutationnovelE12*0.4
UCECchrX23000223Missense_MutationnovelK56Q0.09
UCECchrX23001746Missense_MutationnovelK563N0.27
UCECchrX23000811Missense_Mutationrs371119636A252T0.41KH_1
UCECchrX229999815'UTRNA0.1
UCECchrX23000378SilentNAA107A0.39
UCECchrX23000844Missense_MutationnovelI263L0.58KH_1
UCECchrX23000288Silentrs759217097S77S0.32
UCECchrX23001386SilentnovelQ443Q0.1
UCECchrX230020483'UTRnovel0.34
UCECchrX23001819Missense_MutationnovelR588G0.34
UCECchrX23000520Missense_MutationnovelR155C0.13
UCECchrX23000737Missense_MutationnovelF227C0.13
UCECchrX23001016Nonsense_MutationnovelS320*0.21KH_1
UCECchrX23001602SilentnovelS515S0.41
UCECchrX23001883Frame_Shift_DelnovelK610Efs*410.2
UCECchrX23001195Missense_MutationnovelK380Q0.21KH_1
UCECchrX23001603Missense_Mutationrs751629687G516R0.21
UCECchrX23001705Missense_Mutationrs374604625V550I0.15
UCECchrX23000537Silentrs749049454V160V0.47
UCECchrX23000089Missense_MutationNAA11V0.28
UCECchrX23000667Missense_MutationnovelT204P0.32
UCECchrX23001400Missense_MutationnovelT448I0.04
UCECchrX23000089Missense_MutationNAA11V0.36
UCECchrX23000131Frame_Shift_DelnovelG26Afs*300.08
UCECchrX23000742Nonsense_MutationNAQ229*0.41
UCECchrX23000666Missense_MutationnovelI203M0.39
UCECchrX23000907Missense_MutationNAL284I0.39KH_1
UCECchrX23001866Missense_MutationNAQ603H0.43
UCECchrX23000287Missense_MutationNAS77L0.34
UCECchrX23000314Missense_MutationNAN86S0.36
UCECchrX23000546Silentrs200945232C163C0.3
UCECchrX23000184Missense_MutationnovelA43T0.08
UCECchrX23000504SilentnovelP149P0.47
UCECchrX230020823'UTRnovel0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
READAMP0.1030.13718
SARCAMP0.30740.19108
THCADEL0.0020.21991

Survival Analysis
CancerP-value Q-value

Kaplan-Meier Survival Analysis

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000184735 (Gene tree)
Gene ID
168400
Gene Symbol
DDX53
Alias
CAGE|CT26
Full Name
DEAD-box helicase 53
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
3,629 bases
Position
chrX:22,999,961-23,003,589
Accession
20083
RBP type
canonical RBP
Summary
This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000368667KH_1PF00013.297.4e-1111
ENSP00000368667DEADPF00270.291.4e-4211

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19549529Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.Gastroenterology2009 OctZagani Rdoi: 10.1053/j.gastro.2009.06.039
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000327968DDX53-2013629-ENSP00000368667631 (aa)-Q86TM3
Gene Model
Click here to download ENSG00000184735's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184735's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000184735DDX537135.320ENSG00000198231DDX426235.320
ENSG00000184735DDX535531.638ENSG00000088205DDX185231.638
ENSG00000184735DDX536135.427ENSG00000183258DDX418034.965
ENSG00000184735DDX536943.018ENSG00000108654DDX59853.374
ENSG00000184735DDX535531.034ENSG00000141543EIF4A38331.034
ENSG00000184735DDX536034.715ENSG00000124228DDX278733.469
ENSG00000184735DDX535732.065ENSG00000165732DDX215132.065
ENSG00000184735DDX536035.859ENSG00000067048DDX3Y6035.859
ENSG00000184735DDX535433.523ENSG00000105671DDX497133.523
ENSG00000184735DDX535933.766ENSG00000118197DDX599736.486
ENSG00000184735DDX535130.247ENSG00000156976EIF4A28830.247
ENSG00000184735DDX536632.477ENSG00000278053DDX527232.207
ENSG00000184735DDX536234.091ENSG00000213782DDX478534.091
ENSG00000184735DDX535532.081ENSG00000110367DDX67032.081
ENSG00000184735DDX537043.596ENSG00000100201DDX176043.333
ENSG00000184735DDX535433.429ENSG00000123064DDX549537.745
ENSG00000184735DDX536537.838ENSG00000174243DDX235342.683
ENSG00000184735DDX539961.821ENSG00000080007DDX439661.821
ENSG00000184735DDX535737.366ENSG00000152670DDX46437.366
ENSG00000184735DDX536036.364ENSG00000215301DDX3X8336.364
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000184735DDX539982.006ENSCCAG00000021534-10082.006Cebus_capucinus
ENSG00000184735DDX539982.006ENSCCAG00000024171-10082.006Cebus_capucinus
ENSG00000184735DDX539989.984ENSCSAG00000019540DDX539989.984Chlorocebus_sabaeus
ENSG00000184735DDX5310096.830ENSPPAG00000006869DDX5310096.830Pan_paniscus
ENSG00000184735DDX5310096.513ENSPTRG00000028313DDX5310096.513Pan_troglodytes
ENSG00000184735DDX539994.913ENSPPYG00000020185DDX5310094.913Pongo_abelii
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding-IEAFunction
GO:0004386helicase activity-IEAFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus-IEAComponent
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