EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18801625Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer.Cancer Detect Prev2008Valladares-Ayerbes Mdoi: 10.1016/j.cdp.2008.08.002
25875355MMP7 is required to mediate cell invasion and tumor formation upon Plakophilin3 loss.PLoS One2015 Apr 13Basu Sdoi: 10.1371/journal.pone.0123979
29722422Expression of plakophilin 3 in diffuse malignant pleural mesothelioma.Histol Histopathol2018 SepMai Sdoi: 10.14670/HH-11-996
21947748Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers.Med Oncol2012 SepDemirag GGdoi: 10.1007/s12032-011-0071-1
20348237Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression.Am J Pathol2010 MayBreuninger Sdoi: 10.2353/ajpath.2010.090737
20501752Evaluation of plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients.Cancer Epidemiol Biomarkers Prev2010 JunValladares-Ayerbes Mdoi: 10.1158/1055-9965.EPI-10-0123

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11399033SilentnovelF370F0.33
BLCAchr11404268Missense_MutationNAS768F0.34
BLCAchr11397662Splice_RegionnovelQ356Q0.21
BRCAchr11400018Missense_MutationNAR442K0.19
BRCAchr11397562Missense_MutationNAS323L0.15
BRCAchr11403681Missense_MutationNAR663C0.5
BRCAchr11404567Nonstop_Mutationnovel*798Qext*?0.13
CESCchr11397562Nonsense_MutationnovelS323*0.12
CESCchr11400353Missense_MutationNAQ490K0.45
CESCchr11400063Missense_Mutationrs779832282S457L0.71
CESCchr11400104Missense_Mutationrs368733672E471K0.35
CESCchr11399985Missense_MutationNAS431L0.23
CESCchr11397562Missense_MutationNAS323L0.43
CESCchr11400018Missense_MutationNAR442K0.29
COADchr11400076Frame_Shift_Insrs781609202L464Pfs*2240.46
COADchr11397555Missense_MutationNAL321M0.43
COADchr11397330Nonsense_Mutationrs755412958R277*0.44
COADchr11403108Missense_MutationNAA590T0.48
COADchr11396648SilentnovelF91F0.24
COADchr11397066Missense_Mutationrs554635370G189R0.29
COADchr11400077Frame_Shift_Delrs757594408L464Sfs*1830.22
COADchr11400077Frame_Shift_Delrs757594408L464Sfs*1830.44
COADchr11397258Nonsense_MutationnovelR253*0.15
COADchr11400077Frame_Shift_Delrs757594408L464Sfs*1830.22
COADchr114046303'UTRnovel0.26
COADchr11397604Missense_MutationnovelV337A0.27
COADchr11403707Silentrs142922289Q671Q0.38
GBMchr114046703'UTRnovel0.89
GBMchr11396989Missense_MutationnovelS163F0.54
HNSCchr11404002Frame_Shift_DelnovelP714Qfs*90.33
HNSCchr114046833'UTRnovel0.18
HNSCchr11404005Missense_MutationnovelP714S0.25
HNSCchr11404053Missense_MutationnovelV730M0.22
HNSCchr11399010Missense_Mutationrs141688536V363M0.13
HNSCchr11399093Nonsense_MutationnovelY390*0.27
HNSCchr11404318Missense_MutationnovelR785W0.25
KIRCchr114045963'UTRnovel0.16
KIRPchr11396835Missense_MutationnovelP112T0.38
KIRPchr11404095Missense_Mutationrs201401216G744R0.43
LGGchr11397651Missense_Mutationrs148819261A353T0.13
LGGchr11399104Missense_MutationnovelD394G0.15
LGGchr11396684SilentnovelT103T0.45
LIHCchr11404567Nonstop_Mutationnovel*798Kext*?0.21
LIHCchr11403646In_Frame_InsnovelQ653_E654dup0.05
LIHCchr11399156SilentnovelT411T0.25
LUADchr11397119SilentNAA206A0.38
LUADchr11397046Missense_Mutationrs772575836R182L0.11
LUADchr11403755Missense_MutationNAR687S0.16
LUSCchr11399030SilentNAL369L0.14
LUSCchr11399027Missense_MutationnovelK368N0.36
LUSCchr11399057Missense_MutationnovelQ378H0.34
LUSCchr11404115Missense_MutationnovelF750L0.26
LUSCchr11399087SilentnovelL388L0.31
LUSCchr11397410Nonsense_MutationnovelY303*0.24
LUSCchr11397085Missense_MutationnovelY195C0.39
MESOchr11403767Missense_MutationnovelE691D0.26
OVchr11397268Missense_MutationNAS256N0.62
PAADchr11396980Missense_MutationnovelR160K0.25
PAADchr11399008Missense_MutationnovelA362V0.15
PRADchr114045963'UTRnovel0.43
READchr11400094Missense_Mutationrs775543180Q467H0.54
SARCchr114046153'UTRrs7665155220.15
SKCMchr11404129Missense_Mutationrs79659860R755Q0.24
SKCMchr11400083Missense_Mutationrs764386462L464F0.64
SKCMchr11397067Missense_MutationNAG189E0.17
SKCMchr11397259Missense_MutationNAR253Q0.21
SKCMchr11396916Missense_Mutationrs763137982G139R0.87
SKCMchr11397183Missense_MutationNAG228R0.42
SKCMchr114045863'UTRnovel0.88
SKCMchr114045883'UTRrs7704982340.88
SKCMchr11403755SilentnovelR687R0.11
SKCMchr11404269SilentnovelS768S0.38
SKCMchr11396968Missense_MutationNAP156L0.31
SKCMchr11399048SilentNAQ375Q0.33
SKCMchr114045833'UTRnovel0.14
SKCMchr11404102Missense_MutationNAR746Q0.33
SKCMchr11404551SilentNAE792E0.16
SKCMchr11397656SilentNAK354K0.32
SKCMchr11397559Missense_MutationNAP322L0.2
SKCMchr11399013Missense_Mutationrs767485120P364S0.32
SKCMchr11403636Missense_Mutationrs370327820R648C0.14
SKCMchr11396967Missense_MutationnovelP156S0.29
SKCMchr11397006Missense_MutationNAG169R0.2
SKCMchr11404557SilentNAF794F0.68
SKCMchr11400004SilentNAK437K0.46
SKCMchr11400067SilentnovelG458G0.64
SKCMchr11403947Silentrs560629668T694T0.27
SKCMchr11397181Missense_MutationNAG227E0.51
SKCMchr11400004SilentNAK437K0.2
STADchr11404544Missense_Mutationrs754533171R790Q0.34
STADchr11397114Missense_Mutationrs762556650A205T0.12
STADchr11403637Missense_Mutationrs757603200R648H0.49
STADchr11400009Missense_Mutationrs144679997R439H0.18
STADchr11396663Silentrs773017368Q96Q0.22
STADchr11399100Missense_Mutationrs756559215A393T0.17
STADchr11400055Frame_Shift_DelnovelL456Cfs*1910.33
STADchr11404061Frame_Shift_DelnovelI734Sfs*660.14
STADchr11399184Frame_Shift_DelnovelN422Mfs*150.36
STADchr11397169Missense_MutationNAS223C0.1
STADchr11400071Frame_Shift_Delrs751960573G461Vfs*1860.24
STADchr11397311SilentnovelA270A0.4
STADchr11400076Frame_Shift_Insrs781609202L464Pfs*2240.58
UCECchr11404002Missense_MutationnovelP713S0.46
UCECchr114045773'UTRnovel0.26
UCECchr11396974Missense_MutationNAP158H0.46
UCECchr11397421Missense_MutationnovelR307Q0.5
UCECchr11400076Frame_Shift_Insrs781609202L464Pfs*2240.46
UCECchr11397386Silentrs369281192P295P0.6
UCECchr11404048Missense_Mutationrs755721199L728P0.36
UCECchr11403696Missense_Mutationrs375964684D668N0.3
UCECchr11403710SilentNAL672L0.27
UCECchr11400131Missense_MutationnovelG480S0.13
UCECchr11399007Missense_MutationnovelA362T0.3
UCECchr11400431Missense_MutationnovelA516T0.46
UCECchr11397626SilentnovelQ344Q0.36
UCECchr11404054Missense_Mutationrs201654884V730A0.35
UCECchr11399132Silentrs778602530N403N0.21
UCECchr11399142Missense_Mutationrs770854435E407K0.18
UCECchr11400374Missense_Mutationrs796260537R497W0.41
UCECchr11399972Missense_Mutationrs779964513L427M0.39
UCECchr11403622Missense_Mutationrs201248875A643V0.32
UCECchr11404135Missense_MutationnovelS757I0.24

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.24813.0727e-19
CESCDEL0.29490.02701
ESCAAMP0.11410.018342
ESCADEL0.34780.0016785
GBMDEL0.18370.0048476
HNSCDEL0.24710.00051729
LUADDEL0.18990.00044751
LUSCDEL0.38724.3974e-14
PAADDEL0.10870.022808
PCPGAMP0.03090.23196
PCPGDEL0.33330.00064285
SARCDEL0.39698.2878e-09
TGCTDEL0.560.21504
UCECDEL0.17812.4803e-07

Survival Analysis
CancerP-value Q-value
THYM0.02

Kaplan-Meier Survival Analysis

MESO0.00025

Kaplan-Meier Survival Analysis

ACC0.017

Kaplan-Meier Survival Analysis

SKCM0.036

Kaplan-Meier Survival Analysis

PRAD0.028

Kaplan-Meier Survival Analysis

LUSC0.015

Kaplan-Meier Survival Analysis

PAAD0.00017

Kaplan-Meier Survival Analysis

BLCA0.023

Kaplan-Meier Survival Analysis

CESC0.033

Kaplan-Meier Survival Analysis

KICH0.026

Kaplan-Meier Survival Analysis

UCEC0.044

Kaplan-Meier Survival Analysis

GBM0.0017

Kaplan-Meier Survival Analysis

LUAD0.0015

Kaplan-Meier Survival Analysis

OV0.0077

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000184363 (Gene tree)
Gene ID
11187
Gene Symbol
PKP3
Alias
N
Full Name
plakophilin 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
12,310 bases
Position
chr11:392,599-404,908
Accession
9025
RBP type
non-canonical RBP
Summary
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16407409Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules.Mol Biol Cell2006 MarHofmann I-
23881279Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.Virchows Arch2013 SepYang Cdoi: 10.1007/s00428-013-1452-y
25225333Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.Mol Cell Biol2014 Dec 1Fischer-Keso Rdoi: 10.1128/MCB.00766-14
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000533069PKP3-209590--- (aa)--
ENST00000526971PKP3-204532--- (aa)--
ENST00000527442PKP3-205847-ENSP00000435522120 (aa)-E9PJR7
ENST00000530695PKP3-207441--- (aa)--
ENST00000524646PKP3-202312--- (aa)--
ENST00000531857PKP3-208687-ENSP00000435478212 (aa)-E9PK71
ENST00000525642PKP3-203495-ENSP00000436847115 (aa)-H0YEY5
ENST00000534401PKP3-211756-ENSP00000434517247 (aa)-E9PQ15
ENST00000528036PKP3-206940-ENSP00000434110156 (aa)-E9PRW6
ENST00000533249PKP3-2101111-ENSP00000435383197 (aa)-E9PKC4
ENST00000331563PKP3-2012809-ENSP00000331678797 (aa)-Q9Y446
Gene Model
Click here to download ENSG00000184363's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184363's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001533cornified envelope-TASComponent
GO:0002159desmosome assembly20859650.IMPProcess
GO:0003723RNA binding25225333.IDAFunction
GO:0005515protein binding25225333.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane20859650.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005911cell-cell junction21873635.IBAComponent
GO:0005913cell-cell adherens junction25468996.HDAComponent
GO:0005913cell-cell adherens junction21873635.IBAComponent
GO:0006417regulation of translation25225333.IMPProcess
GO:0007043cell-cell junction assembly21873635.IBAProcess
GO:0010628positive regulation of gene expression25225333.IMPProcess
GO:0019899enzyme binding25225333.IPIFunction
GO:0030054cell junction-IDAComponent
GO:0030057desmosome-IEAComponent
GO:0031424keratinization-TASProcess
GO:0045182translation regulator activity25225333.IMPFunction
GO:0045294alpha-catenin binding23136403.IPIFunction
GO:0045296cadherin binding21873635.IBAFunction
GO:0050839cell adhesion molecule binding20859650.IPIFunction
GO:0070268cornification-TASProcess
GO:0072659protein localization to plasma membrane20859650.IMPProcess
GO:0098609cell-cell adhesion21873635.IBAProcess
GO:0098641cadherin binding involved in cell-cell adhesion25468996.HDAFunction
GO:1902373negative regulation of mRNA catabolic process25225333.IMPProcess
GO:1990124messenger ribonucleoprotein complex25225333.IDAComponent
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