EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr627867514Missense_MutationnovelP6A0.11
BLCAchr627867430Missense_MutationnovelA34T0.28
BLCAchr6278675515'Flankrs7630890070.41
BLCAchr627867399Nonsense_MutationnovelS44*0.44
BLCAchr627867200SilentNAL110L0.2
BLCAchr627867482SilentNAE16E0.69
BLCAchr627866936SilentNAP198P0.27
BLCAchr627867056In_Frame_Delrs545007006T155_K158del0.11
BLCAchr627866878Frame_Shift_DelnovelA218Pfs*?0.22
BLCAchr627866879Missense_MutationnovelK217N0.22
BLCAchr627866914Missense_MutationNAA206T0.19
BLCAchr627867257SilentnovelV91V0.17
BRCAchr627867086Silentrs368971921A148A0.21
BRCAchr627866966Missense_MutationNAK188N0.23
BRCAchr6278723225'Flankrs1905826040.27
BRCAchr627867101Missense_MutationNAK143N0.33
BRCAchr6278718665'Flanknovel0.37
BRCAchr627867416Silentrs756173269A38A0.06
CESCchr627867086SilentNAA148A0.25
CESCchr6278718945'Flankrs3681448110.23
CESCchr6278675515'Flankrs7630890070.21
CESCchr6278718865'Flanknovel0.25
CESCchr627866936SilentNAP198P0.33
CESCchr627866966Missense_MutationNAK188N0.45
CESCchr627867186Missense_Mutationrs541014157A115V0.31
CESCchr6278668013'Flanknovel0.42
CESCchr627866966Missense_MutationNAK188N0.37
CESCchr627866936SilentNAP198P0.72
CESCchr627866901In_Frame_Delrs758100284P213_K217del0.33
CESCchr627867525Missense_MutationNAS2L0.3
CESCchr6278668353'Flanknovel0.25
CESCchr627867101Silentrs780923320K143K0.29
CESCchr627866981SilentnovelP183P0.52
CESCchr627867110SilentNAK140K0.38
CESCchr627866936SilentNAP198P0.4
COADchr627867050Silentrs764722398K160K0.25
COADchr627866887Missense_MutationNAA215T0.32
COADchr627866894SilentNAK212K0.23
COADchr627867149SilentnovelG127G0.08
COADchr627867177Frame_Shift_InsNAE118Gfs*130.16
COADchr627867179SilentnovelG117G0.06
COADchr627867081Missense_MutationNAK150R0.25
COADchr627866877Missense_Mutationrs775091070A218V0.09
COADchr627867151Missense_MutationNAG127S0.29
DLBCchr627867138Missense_Mutationrs199758872A131V0.3
DLBCchr627867264Missense_Mutationrs771262830S89N0.17
DLBCchr627867213Missense_MutationnovelG106A0.45
ESCAchr627867436Missense_MutationnovelG32S0.14
ESCAchr627867081Missense_MutationNAK150R0.58
ESCAchr627867467Silentrs758785999K21K0.36
ESCAchr627867071Missense_Mutationrs776470457K153N0.41
ESCAchr6278718605'Flanknovel0.59
ESCAchr627867169Missense_MutationnovelP121S0.21
GBMchr627867074SilentnovelV152V0.1
HNSCchr627867020SilentnovelV170V0.31
HNSCchr627867136Missense_MutationnovelK132E0.25
HNSCchr627866936SilentNAP198P0.36
HNSCchr627867392Silentrs374541448L46L0.22
HNSCchr6278667983'Flanknovel0.24
HNSCchr6278718735'Flanknovel0.2
HNSCchr627867421Missense_MutationnovelK37Q0.25
HNSCchr6278668353'Flanknovel0.14
HNSCchr627867000Missense_MutationnovelA177V0.32
HNSCchr627867342Frame_Shift_DelnovelL60Sfs*30.07
HNSCchr627867343Frame_Shift_DelnovelA63Qfs*70.09
HNSCchr627867096Missense_MutationnovelA145D0.16
HNSCchr627867169Missense_MutationnovelP121A0.13
KIRPchr627866879In_Frame_DelnovelP203_K217del0.07
LIHCchr627866968Missense_Mutationrs745570564K188E0.23
LIHCchr627866937Missense_MutationnovelP198Q0.52
LIHCchr6278723185'Flankrs7491221670.15
LUADchr627867432Missense_MutationNAA33D0.08
LUADchr627867116SilentnovelT138T0.23
LUADchr627867360Missense_MutationNAR57L0.2
LUADchr627867362SilentnovelE56E0.07
LUADchr627866879Missense_MutationNAK217N0.4
LUADchr627867399Missense_MutationnovelS44L0.07
LUADchr627867148Missense_MutationnovelA128S0.08
LUADchr627867444Missense_MutationNAA29G0.08
LUADchr627867304Missense_MutationnovelV76M0.06
LUADchr627867334Missense_MutationnovelK66E0.41
LUSCchr6278718565'Flankrs7685918700.2
LUSCchr627867024Missense_MutationNAK169M0.58
LUSCchr6278718535'Flanknovel0.47
LUSCchr6278718975'Flanknovel0.18
LUSCchr6278668033'Flanknovel0.24
LUSCchr627867197Missense_MutationnovelN111K0.15
LUSCchr627867392SilentNAL46L0.24
LUSCchr627867193Missense_MutationnovelK113E0.34
LUSCchr627867416SilentNAA38A0.58
LUSCchr6278723185'Flankrs7491221670.23
OVchr6278675635'Flanknovel0.13
OVchr6278718865'Flanknovel0.13
PAADchr627867056In_Frame_Delrs545007006T155_K158del0.12
PAADchr627867222Missense_MutationnovelG103D0.17
READchr627867042Missense_MutationNAA163E0.46
READchr627867375Missense_Mutationrs780574435A52V0.31
READchr627867239SilentNAV97V0.14
READchr627866918Missense_MutationNAK204N0.38
READchr627867348Missense_MutationnovelS61Y0.13
SARCchr627867496Missense_MutationnovelP12S0.09
SKCMchr627867275SilentnovelL85L0.28
SKCMchr627867233SilentNAT99T0.27
SKCMchr627867337Missense_Mutationrs776773973L65F0.17
SKCMchr627866876SilentNAA218A0.17
SKCMchr627867005SilentNAK175K0.48
SKCMchr627867125SilentnovelA135A0.19
SKCMchr627867098In_Frame_DelnovelP134_K144del0.05
SKCMchr627867263Silentrs372908864S89S0.74
SKCMchr627867056Silentrs143393068K158K0.52
SKCMchr627867513Missense_Mutationrs773069523P6L0.6
SKCMchr627867045Missense_MutationNAP162L0.29
SKCMchr627867158SilentNAK124K0.26
SKCMchr6278675685'Flanknovel0.19
SKCMchr627867332SilentNAK66K0.39
SKCMchr627867302Silentrs781695711V76V0.26
SKCMchr627867122SilentnovelG136G0.3
SKCMchr627867123Missense_MutationnovelG136E0.3
SKCMchr627867129Missense_MutationNAP134L0.85
SKCMchr627866970Missense_Mutationrs779719317T187I0.23
STADchr627866896Nonsense_MutationNAK212*0.12
STADchr627866873In_Frame_DelnovelP198_K219del0.27
STADchr627866869Missense_MutationNAA221T0.24
STADchr627867308SilentNAY74Y0.09
STADchr627867518SilentnovelT4T0.17
STADchr627867227SilentnovelG101G0.05
STADchr627867050Missense_MutationnovelK160N0.13
STADchr627867144Missense_MutationNAA129V0.08
STADchr627867256Missense_MutationnovelS92R0.28
STADchr627867110SilentNAK140K0.23
STADchr6278668353'Flanknovel0.36
STADchr627866971Missense_MutationNAT187A0.42
STADchr627867225In_Frame_DelnovelL96_T102del0.14
STADchr6278675615'Flanknovel0.72
STADchr627866895Missense_MutationNAK212R0.22
TGCTchr627866928Missense_MutationnovelA201V0.21
UCECchr627867131Silentrs750300228K133K0.39
UCECchr627867475Missense_MutationnovelP19S0.48
UCECchr627866873Silentrs776382299K219K0.21
UCECchr627866994Missense_MutationnovelA179V0.44
UCECchr627866855Missense_Mutationrs769817801K225N0.12
UCECchr6278718865'Flanknovel0.1
UCECchr627867312Missense_MutationNAG73D0.32
UCECchr627867287SilentnovelS81S0.43
UCECchr627867086SilentNAA148A0.42
UCECchr627867026SilentnovelK168K0.24
UCECchr627867502Missense_MutationnovelA10S0.37
UCECchr627867249Missense_MutationNAG94D0.32
UCECchr627866961Missense_MutationnovelP190H0.28
UCECchr627867018Missense_Mutationrs748940475A171V0.16
UCECchr627867317Silentrs749604290A71A0.33
UCECchr627867224SilentNAT102T0.32
UCECchr627867031Missense_MutationnovelV167I0.06
UCECchr627866868Missense_Mutationrs748484962A221V0.57
UCECchr6278718465'Flanknovel0.16
UCECchr627867063Missense_MutationnovelP156L0.36
UCSchr627867062SilentnovelP156P0.14

Copy Number Variations (CNVs)
CancerTypeFreq Q-value

Survival Analysis
CancerP-value Q-value
THYM0.033

Kaplan-Meier Survival Analysis

KIRC0.00077

Kaplan-Meier Survival Analysis

STAD0.0039

Kaplan-Meier Survival Analysis

SARC0.023

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.00017

Kaplan-Meier Survival Analysis

UCS0.016

Kaplan-Meier Survival Analysis

HNSC0.028

Kaplan-Meier Survival Analysis

ESCA0.0024

Kaplan-Meier Survival Analysis

PAAD0.017

Kaplan-Meier Survival Analysis

CESC0.00037

Kaplan-Meier Survival Analysis

READ0.012

Kaplan-Meier Survival Analysis

LAML0.042

Kaplan-Meier Survival Analysis

LIHC0.012

Kaplan-Meier Survival Analysis

DLBC0.042

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.014

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000184357 (Gene tree)
Gene ID
3009
Gene Symbol
HIST1H1B
Alias
H1.5|H1b|H1s-3|H1F5
Full Name
histone cluster 1 H1 family member b
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
790 bases
Position
chr6:27,866,792-27,867,581
Accession
4719
RBP type
non-canonical RBP
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000331442HIST1H1B-201681-ENSP00000330074226 (aa)-P16401
Gene Model
Click here to download ENSG00000184357's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000184357Lupus Erythematosus, Systemic3.81881E-918204098
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184357's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0000122negative regulation of transcription by RNA polymerase II22956909.IMPProcess
GO:0000786nucleosome-IEAComponent
GO:0000790nuclear chromatin19882353.22956909.IDAComponent
GO:0003690double-stranded DNA binding21873635.IBAFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding26496610.30021884.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus21383955.IDAComponent
GO:0005720nuclear heterochromatin21873635.IBAComponent
GO:0005720nuclear heterochromatin15911621.IDAComponent
GO:0006325chromatin organization22956909.IMPProcess
GO:0006334nucleosome assembly-IEAProcess
GO:0006355regulation of transcription, DNA-templated21873635.IBAProcess
GO:0016584nucleosome positioning21873635.IBAProcess
GO:0030261chromosome condensation21873635.IBAProcess
GO:0030307positive regulation of cell growth22956909.IMPProcess
GO:0031490chromatin DNA binding15911621.22956909.IMPFunction
GO:0031492nucleosomal DNA binding21873635.IBAFunction
GO:0031936negative regulation of chromatin silencing21873635.IBAProcess
GO:0042826histone deacetylase binding21873635.IBAFunction
GO:0042826histone deacetylase binding22956909.IPIFunction
GO:0045910negative regulation of DNA recombination21873635.IBAProcess
GO:0050821protein stabilization22956909.IMPProcess
GO:0051574positive regulation of histone H3-K9 methylation21873635.IBAProcess
GO:0051574positive regulation of histone H3-K9 methylation22956909.IMPProcess
GO:0071169establishment of protein localization to chromatin21873635.IBAProcess
GO:0071169establishment of protein localization to chromatin22956909.IMPProcess
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