EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17657734Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.Hepatology2007 OctRousseau B-
20346530In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence.J Hepatol2010 MayM??nard Ldoi: 10.1016/j.jhep.2009.12.029
27999200Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.Oncotarget2017 Jan 31Breig Odoi: 10.18632/oncotarget.13975.
21763315RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer.FEBS Lett2011 Aug 4Flavin Pdoi: 10.1016/j.febslet.2011.07.005
16699503Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis.Nat Cell Biol2006 JunKim JH-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1949004307Missense_MutationnovelA52T0.55
BLCAchr19489938905'UTRnovel0.21
BLCAchr1949011039SilentNAI276I0.24
BLCAchr1949007081Missense_MutationNAS110F0.2
BLCAchr1949007064Silentrs372090262A104A0.18
BLCAchr1949010496Silentrs767682271F224F0.09
BLCAchr1949004384SilentnovelG77G0.1
BLCAchr1949015822Missense_MutationNAE458K0.21
BRCAchr1949004396Silentrs377545771T81T0.31
BRCAchr19490158573'UTRnovel0.13
BRCAchr19489938055'UTRnovel0.27
BRCAchr1949014481Splice_SitenovelX334_splice0.18
BRCAchr19489937895'UTRnovel0.2
BRCAchr1949010037Missense_MutationNAA212T0.5
CESCchr19489938075'UTRnovel0.32
CESCchr1949007140Missense_MutationNAR130C0.33
CESCchr1949010449Intronnovel0.27
CESCchr1949015141Silentrs779474986R414R0.36
CESCchr1949007329Silentrs766947238E141E0.11
CESCchr1949010077Intronnovel0.47
CHOLchr1949015671Missense_MutationnovelL451I0.16
COADchr1949010037Missense_MutationNAA212T0.35
COADchr1949015097Missense_Mutationrs767467214R400C0.26
COADchr1949010002Missense_MutationnovelG200V0.06
COADchr1949007046Silentrs370116802T98T0.19
COADchr1949014514Silentrs377518857H344H0.39
COADchr1949007136Silentrs760854037G128G0.18
COADchr1949014488Missense_MutationNAR336W0.34
COADchr1949011290SilentNAA327A0.29
COADchr1949004324SilentnovelG57G0.32
COADchr1949010514SilentNAG230G0.5
COADchr19489939075'UTRrs7665556620.19
COADchr1949014583Silentrs758668870T367T0.18
COADchr1949014536Missense_MutationNAD352N0.31
GBMchr1948999360SilentnovelR18R0.13
GBMchr1949011228Missense_MutationnovelE307K0.23
GBMchr1949014578Missense_MutationnovelD366Y0.45
GBMchr1949015607SilentnovelV429V0.24
GBMchr19490158723'UTRnovel0.44
GBMchr1949007351Nonsense_MutationNAR149*0.42
GBMchr1949011253Missense_MutationNAA315D0.05
GBMchr1949004418Missense_MutationNAG89S0.28
HNSCchr1949011031Missense_MutationnovelE274Q0.14
HNSCchr19489938155'UTRnovel0.16
HNSCchr1949009880Splice_Regionrs185487314A189A0.23
HNSCchr1949004402Missense_MutationnovelK83N0.19
HNSCchr1949009859SilentnovelL182L0.07
HNSCchr1949010096Intronnovel0.55
HNSCchr1949011027SilentnovelV272V0.14
KIRCchr1949010088Intronnovel0.15
KIRCchr1949014483Splice_SiteNAX334_splice0.15
KIRCchr1949007126Missense_MutationNAR125P0.27
KIRPchr1949007080Missense_MutationNAS110P0.36
KIRPchr1949014564Missense_MutationnovelP361H0.3
LAMLchr1949007351Nonsense_MutationNAR149*0.16
LGGchr1949015578Missense_MutationNAE420K0.25
LIHCchr1949003314Missense_MutationNAD35N0.46
LIHCchr1949010492Missense_MutationnovelK223R0.3
LUADchr1949015596Missense_MutationNAI426V0.77
LUADchr1949010478Intronnovel0.42
LUADchr1949015816Splice_SiteNAX456_splice0.18
LUADchr1949007314Missense_MutationnovelE136D0.23
LUADchr1949003289SilentnovelS26S0.34
LUSCchr1949011249Missense_Mutationrs187501901R314W0.47
LUSCchr1949010998Splice_SitenovelX263_splice0.27
LUSCchr1949010512Missense_MutationnovelG230W0.16
LUSCchr1949010474Intronnovel0.56
LUSCchr1949007025SilentnovelA91A0.25
OVchr1949014524Missense_MutationNAI348V0.36
OVchr1949011238Missense_MutationNAS310F0.36
OVchr1948999366Missense_MutationnovelE20D0.06
OVchr1948999367Missense_MutationnovelR21G0.06
PAADchr1949004350Missense_MutationnovelG66V0.17
PAADchr1949007141Missense_Mutationrs754112742R130H0.04
PAADchr1949007320Silentrs750573386I138I0.1
PAADchr1949010058Missense_MutationnovelG219C0.19
PRADchr1949004396Silentrs377545771T81T0.11
PRADchr1949007141Missense_Mutationrs754112742R130H0.46
PRADchr1949014604Splice_SiteNAX374_splice0.36
READchr1949011309Nonsense_MutationNAR334*0.5
READchr1949007024Missense_Mutationrs761782658A91V0.24
READchr1949009830Missense_MutationNAD173N0.15
SARCchr1949011094Splice_SitenovelX294_splice0.27
SARCchr1949014602Missense_MutationnovelR374W0.11
SARCchr1949010020Missense_MutationnovelG206A0.56
SKCMchr1949004408SilentnovelA85A0.29
SKCMchr1949003300Missense_MutationNAG30E0.37
SKCMchr1948999337Missense_MutationNAP11S0.24
SKCMchr19489938085'UTRnovel0.36
SKCMchr1949004358Missense_MutationNAA69S0.29
SKCMchr1949011254SilentnovelA315A0.24
SKCMchr1949011255SilentnovelL316L0.22
SKCMchr1949004371Missense_MutationNAV73D0.41
SKCMchr1949007341SilentnovelI145I0.57
SKCMchr1949007342Nonsense_MutationnovelQ146*0.57
SKCMchr1949007318Missense_MutationNAI138V0.14
SKCMchr1949009883Splice_SitenovelX190_splice0.38
STADchr1949004384SilentnovelG77G0.36
STADchr1949004309SilentnovelA52A0.13
STADchr1949009813Missense_MutationnovelE167V0.16
STADchr1949010000Silentrs550156979T199T0.35
STADchr1949007140Missense_MutationNAR130C0.36
STADchr1949011309Nonsense_MutationNAR334*0.23
STADchr1949015581Missense_MutationnovelV421M0.24
STADchr1949007032Missense_MutationNAL94M0.51
STADchr1949015686Splice_SitenovelX456_splice0.18
STADchr1949011198Missense_MutationNAF297V0.34
STADchr1949007310Missense_Mutationrs776647069T135M0.31
STADchr1949010023Missense_Mutationrs762109573R207H0.31
UCECchr1949014582Missense_Mutationrs750596061T367M0.13
UCECchr1949011054SilentnovelA281A0.29
UCECchr1949011077Missense_MutationNAA289V0.46
UCECchr1949015589SilentnovelV423V0.35
UCECchr1949007136Silentrs760854037G128G0.29
UCECchr1949015660Missense_MutationnovelQ447R0.62
UCECchr1949004397Missense_MutationNAG82W0.32
UCECchr1949015605Missense_MutationNAV429I0.22
UCECchr1949010569Missense_Mutationrs770719600V249I0.17
UCECchr1949004281Missense_MutationNAS43L0.5
UCECchr19489937955'UTRnovel0.5
UCECchr1949010391Intronnovel0.43
UCECchr1949009802SilentnovelL163L0.26
UCECchr1948999338Missense_Mutationrs371296069P11L0.41
UCECchr1949009880Splice_Regionrs185487314A189A0.4
UCECchr1949015655Missense_MutationnovelE445D0.22
UCECchr19489936965'UTRnovel0.6
UCECchr1949014551Missense_Mutationrs772738446V357I0.51
UCECchr1949015079Missense_MutationnovelG394R0.29
UCECchr1949015664Silentrs757058036D448D0.3
UCECchr1949014572Missense_Mutationrs760317774E364K0.32
UCECchr1949015062Missense_Mutationrs779661942T388M0.4
UCECchr1949003294Missense_MutationnovelI28T0.31
UCECchr19490159273'UTRnovel0.38
UCECchr1949011014Missense_MutationnovelI268N0.29
UCECchr19489937725'UTRnovel0.5
UCECchr1949010005Missense_MutationNAK201R0.17
UCECchr1949010048Silentrs138614683Y215Y0.48

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.08810.027508
KIRPDEL0.04860.054726
LUADDEL0.25391.5526e-05
LUSCDEL0.20961.1877e-06
PAADDEL0.0870.035089
READDEL0.09090.23023
TGCTDEL0.28670.0046229
UCSDEL0.19640.12448

Survival Analysis
CancerP-value Q-value
KIRC0.0008

Kaplan-Meier Survival Analysis

SARC0.0042

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00018

Kaplan-Meier Survival Analysis

HNSC0.0022

Kaplan-Meier Survival Analysis

SKCM0.002

Kaplan-Meier Survival Analysis

TGCT0.02

Kaplan-Meier Survival Analysis

CESC0.04

Kaplan-Meier Survival Analysis

LIHC0.0015

Kaplan-Meier Survival Analysis

DLBC0.034

Kaplan-Meier Survival Analysis

LGG0.00016

Kaplan-Meier Survival Analysis

LUAD0.0017

Kaplan-Meier Survival Analysis

UVM0.007

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000183207 (Gene tree)
Gene ID
10856
Gene Symbol
RUVBL2
Alias
RVB2|TIP48|TIP49b|Reptin52|ECP51|TIH2|INO80J|Rvb2
Full Name
RuvB like AAA ATPase 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
22,643 bases
Position
chr19:48,993,353-49,015,995
Accession
10475
RBP type
non-canonical RBP
Summary
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23938467Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.Mol Cell Proteomics2013 NovChapman KMdoi: 10.1074/mcp.M113.030585
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000595811RUVBL2-207572-ENSP0000046976044 (aa)-M0QYD8
ENST00000639391RUVBL2-213120-ENSP0000049256439 (aa)-A0A1W2PS22
ENST00000595002RUVBL2-205546--- (aa)--
ENST00000596837RUVBL2-209682-ENSP00000469189109 (aa)-M0QXI6
ENST00000593570RUVBL2-202813-ENSP0000046948839 (aa)-M0QXZ7
ENST00000598768RUVBL2-210497--- (aa)--
ENST00000221413RUVBL2-2011478-ENSP00000221413259 (aa)-X6R2L4
ENST00000595090RUVBL2-2062009-ENSP00000473172463 (aa)-Q9Y230
ENST00000601968RUVBL2-2111641XM_011526330ENSP00000471524354 (aa)XP_011524632M0R0Y3
ENST00000596247RUVBL2-2081563-ENSP0000047153850 (aa)-M0R0Z0
ENST00000640699RUVBL2-214153-ENSP0000049261050 (aa)-A0A1W2PS48
ENST00000594017RUVBL2-203959--- (aa)--
ENST00000627972RUVBL2-2121065-ENSP00000486242354 (aa)-M0R0Y3
ENST00000594338RUVBL2-2041853--- (aa)--
Gene Model
Click here to download ENSG00000183207's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000183207Follicle Stimulating Hormone4E-824049095
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000183207rs752875991949013883TBlood protein levels29875488[0.33-0.53] unit decrease0.43EFO_0007937
ENSG00000183207rs797859701949014074GBlood protein levels29875488[1.03-1.19] unit increase1.11EFO_0007937
ENSG00000183207rs1396432501949013889TBlood protein levels29875488[0.58-0.78] unit decrease0.68EFO_0007937
ENSG00000183207rs37646181948993898?Follicule stimulating hormone24049095EFO_0004768
ENSG00000183207rs7533071949015227CBlood protein levels28240269[0.19-0.32] unit increase0.256EFO_0008156
ENSG00000183207rs795027421948997109GBlood protein levels30072576[NR] unit decrease0.9031508EFO_0007937
ENSG00000183207rs795027421948997109GBlood protein levels30072576[NR] unit increase0.7314155EFO_0007937
ENSG00000183207rs795027421948997109GBlood protein levels30072576[0.54-0.65] unit increase0.594EFO_0007937
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000183207's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000183207RUVBL210079.817FBgn0040075rept9478.146Drosophila_melanogaster
ENSG00000183207RUVBL29257.000ENSG00000175792RUVBL110051.908Homo_sapiens
ENSG00000183207RUVBL2100100.000ENSMUSG00000003868Ruvbl210099.568Mus_musculus
ENSG00000183207RUVBL29257.000ENSMUSG00000030079Ruvbl110047.761Mus_musculus
ENSG00000183207RUVBL29978.704YPL235WRVB29468.764Saccharomyces_cerevisiae
ENSG00000183207RUVBL29253.000YDR190CRVB19442.597Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000492box C/D snoRNP assembly21873635.IBAProcess
GO:0000812Swr1 complex21873635.IBAComponent
GO:0000812Swr1 complex24463511.IDAComponent
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding23637611.IDAFunction
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding23637611.IDAFunction
GO:0001094TFIID-class transcription factor complex binding-IEAFunction
GO:0003678DNA helicase activity10524211.IDAFunction
GO:0003714transcription corepressor activity11080158.IDAFunction
GO:0004003ATP-dependent DNA helicase activity21873635.IBAFunction
GO:0005515protein binding10966108.11080158.16189514.16230350.17636026.18026119.18087039.18358808.19299493.19433865.20371770.20864032.25416956.27705803.29601588.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus10524211.18026119.19433865.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005719nuclear euchromatin23637611.IDAComponent
GO:0005737cytoplasm19433865.IDAComponent
GO:0005813centrosome-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0006281DNA repair-IEAProcess
GO:0006310DNA recombination-IEAProcess
GO:0006338chromatin remodeling21873635.IBAProcess
GO:0006338chromatin remodeling23637611.IMPProcess
GO:0006357regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0006457protein folding10524211.TASProcess
GO:0008013beta-catenin binding11080158.IDAFunction
GO:0016020membrane-IEAComponent
GO:0016363nuclear matrix-IEAComponent
GO:0016573histone acetylation21873635.IBAProcess
GO:0016887ATPase activity10966108.IDAFunction
GO:0017025TBP-class protein binding11080158.IDAFunction
GO:0031011Ino80 complex21873635.IBAComponent
GO:0031011Ino80 complex18026119.21303910.IDAComponent
GO:0031490chromatin DNA binding23637611.IDAFunction
GO:0032508DNA duplex unwinding-IEAProcess
GO:0034644cellular response to UV18026119.IMPProcess
GO:0035066positive regulation of histone acetylation23637611.IMPProcess
GO:0035267NuA4 histone acetyltransferase complex21873635.IBAComponent
GO:0035267NuA4 histone acetyltransferase complex10966108.14966270.IDAComponent
GO:0040008regulation of growth-IEAProcess
GO:0042802identical protein binding10966108.IDAFunction
GO:0042802identical protein binding10966108.21988832.22748767.IPIFunction
GO:0042803protein homodimerization activity-IEAFunction
GO:0043141ATP-dependent 5'-3' DNA helicase activity-IEAFunction
GO:0043531ADP binding-IEAFunction
GO:0043967histone H4 acetylation14966270.IDAProcess
GO:0043968histone H2A acetylation14966270.IDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II23637611.IMPProcess
GO:0051082unfolded protein binding10524211.TASFunction
GO:0051117ATPase binding-IEAFunction
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071169establishment of protein localization to chromatin23637611.IMPProcess
GO:0071339MLL1 complex15960975.IDAComponent
GO:0071392cellular response to estradiol stimulus23637611.IMPProcess
GO:0071733transcriptional activation by promoter-enhancer looping23637611.IMPProcess
GO:0071899negative regulation of estrogen receptor binding23637611.IMPProcess
GO:0090090negative regulation of canonical Wnt signaling pathway11080158.IDAProcess
GO:0097255R2TP complex21873635.IBAComponent
GO:0097255R2TP complex26711270.IDAComponent
GO:1903507negative regulation of nucleic acid-templated transcription-IEAProcess
GO:1904874positive regulation of telomerase RNA localization to Cajal body25467444.HMPProcess
GO:1990904ribonucleoprotein complex-IEAComponent
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