EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27611951Aberrant expression of KPNA2 is associated with a poor prognosis and contributes to OCT4 nuclear transportation in bladder cancer.Oncotarget2016 Nov 8Zhou Jdoi: 10.18632/oncotarget.11889.
20393006Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma.Anticancer Res2010 MarSakai M-
22962582Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis.PLoS One2012He Ldoi: 10.1371/journal.pone.0042992
24799195Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.Hepatology2014 SepWinkler Jdoi: 10.1002/hep.27207
16188882Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.J Biol Chem2005 Nov 25Tseng SF-
30115078KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc.J Exp Clin Cancer Res2018 Aug 16Li Jdoi: 10.1186/s13046-018-0861-9.
22125623Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.PLoS One2011van der Watt PJdoi: 10.1371/journal.pone.0027723
20859152Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis.Obstet Gynecol2010 OctZheng Mdoi: 10.1097/AOG.0b013e3181f104ce.
20658535Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome.Int J Cancer2011 May 15Wang CIdoi: 10.1002/ijc.25568.
16818692Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer.Clin Cancer Res2006 Jul 1Dahl E-
23536776Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker.PLoS One2013Rachidi SMdoi: 10.1371/journal.pone.0057911
19117056The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.Int J Cancer2009 Apr 15van der Watt PJdoi: 10.1002/ijc.24146.
23749771Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer.Carcinogenesis2013 OctAltan Bdoi: 10.1093/carcin/bgt214
17899179KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ.Virchows Arch2007 NovDankof A-
21220479KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy.Clin Cancer Res2011 Mar 1Mortezavi Adoi: 10.1158/1078-0432.CCR-10-0081
25728791Quantitative proteomics reveals a novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.J Proteome Res2015 Apr 3Wang CIdoi: 10.1021/pr501097a
23887301High nuclear karyopherin α 2 expression is a strong and independent predictor of biochemical recurrence in prostate cancer patients treated by radical prostatectomy.Mod Pathol2014 JanGrupp Kdoi: 10.1038/modpathol.2013.127
27154959Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport.J Biochem2016 NovYasuhara N-
26887791Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.Sci Rep2016 Feb 18Yamada Kdoi: 10.1038/srep21410.
24070213Downregulation of KPNA2 in non-small-cell lung cancer is associated with Oct4 expression.J Transl Med2013 Sep 26Li XLdoi: 10.1186/1479-5876-11-232.
21909132Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro.Oncogene2012 Apr 19Noetzel Edoi: 10.1038/onc.2011.403
27107455Induction of immunogenic cell death by radiation-upregulated karyopherin alpha 2 in vitro.Eur J Cell Biol2016 Jun-JulSong KHdoi: 10.1016/j.ejcb.2016.04.002
18561322Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity.Int J Cancer2008 Sep 15Gluz Odoi: 10.1002/ijc.23628.
26626145Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer.J Exp Clin Cancer Res2015 Dec 1Zhang Ydoi: 10.1186/s13046-015-0261-3.
21330047High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy.Eur Urol2011 MayJensen JBdoi: 10.1016/j.eururo.2011.01.048
28875407Karyopherin α-2 is a reliable marker for identification of patients with high-risk stage II colorectal cancer.J Cancer Res Clin Oncol2017 DecJeong Ddoi: 10.1007/s00432-017-2512-5
27009856mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells.Oncotarget2016 May 3Wang CIdoi: 10.18632/oncotarget.8170.
27078844MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer.Oncotarget2016 Jun 28Tsai MMdoi: 10.18632/oncotarget.8629.
27974678Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis.Oncotarget2017 Jan 3Zhou LNdoi: 10.18632/oncotarget.13863.
30254209E2F1 and E2F7 differentially regulate KPNA2 to promote the development of gallbladder cancer.Oncogene2019 FebXiang Sdoi: 10.1038/s41388-018-0494-7

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1768037485Missense_Mutationrs369989302R68H0.15
BLCAchr1768037463Missense_Mutationrs782088901T61A0.54
BLCAchr1768044014Missense_MutationNAQ369H0.48
BLCAchr1768037379Missense_MutationnovelE33Q0.32
BLCAchr1768045773Missense_MutationnovelA450V0.42
BLCAchr1768040743SilentnovelQ93Q0.13
BLCAchr1768042186Missense_MutationnovelP135H0.15
BRCAchr1768044031Missense_MutationNAN375S0.24
BRCAchr17680467713'UTRnovel0.17
BRCAchr1768044004Missense_Mutationrs782787344R366H0.24
BRCAchr1768040699Missense_MutationNAD79N0.24
BRCAchr1768044051Missense_MutationnovelL382F0.08
BRCAchr1768037367Missense_Mutationrs782272780R29C0.46
CESCchr1768042260Missense_MutationNAD160H0.24
CESCchr1768043900SilentNAV331V0.2
CESCchr1768043311Missense_MutationNAG293V0.21
CESCchr1768043286Nonsense_MutationNAR285*0.09
CESCchr1768042982Missense_MutationNAD217H0.21
CESCchr1768044490Nonsense_MutationnovelS445*0.05
COADchr1768037199Missense_Mutationrs183061920D23N0.3
COADchr1768043112Missense_Mutationrs782396125R227C0.1
COADchr1768042110Missense_MutationnovelP110S0.22
COADchr1768043168Silentrs782575040P245P0.25
COADchr1768043854Missense_MutationNAA316V0.26
COADchr17680467493'UTRnovel0.27
ESCAchr1768044001Missense_MutationnovelG365V0.15
GBMchr1768042156Missense_MutationnovelV125G0.04
GBMchr1768043279SilentnovelP282P0.06
GBMchr1768042119Missense_MutationnovelD113Y0.05
GBMchr1768043258SilentnovelI275I0.1
GBMchr1768042174Missense_MutationnovelT131N0.08
GBMchr1768042184SilentnovelS134S0.11
GBMchr1768043179Missense_MutationnovelV249A0.2
GBMchr17680466413'UTRnovel0.45
GBMchr1768037471Silentrs782745827P63P0.36
HNSCchr1768043134Missense_Mutationrs782797109S234C0.3
HNSCchr1768043193Missense_MutationnovelP254S0.14
HNSCchr1768045919Missense_MutationnovelE499K0.19
HNSCchr1768044394Missense_MutationnovelI413N0.25
HNSCchr1768037457Missense_MutationnovelD59N0.45
HNSCchr1768043915Silentrs781940531A336A0.18
HNSCchr1768046569Frame_Shift_InsnovelA523Gfs*60.21
KIRCchr1768046580Missense_MutationNAG525V0.26
KIRPchr1768043200Missense_MutationnovelL256S0.54
LGGchr1768043971Missense_MutationnovelA355V0.36
LIHCchr1768044434Missense_MutationNAM426I0.12
LIHCchr1768043995Missense_MutationnovelT363R0.45
LIHCchr1768045786SilentnovelL454L0.19
LIHCchr1768042219Missense_MutationNAN146S0.69
LUADchr1768037179Missense_MutationnovelR16K0.28
LUADchr1768042278Missense_MutationNAA166S0.19
LUADchr1768042949Missense_MutationNAV206F0.4
LUADchr1768045903Missense_MutationNAE493D0.19
LUSCchr1768044006Nonsense_MutationNAQ367*0.22
LUSCchr17680466493'UTRnovel0.15
LUSCchr1768043286Nonsense_MutationNAR285*0.39
LUSCchr1768037181Missense_MutationNAF17I0.69
OVchr1768042922Nonsense_MutationnovelR197*0.09
OVchr1768042975SilentnovelA214A0.08
OVchr1768042114Missense_MutationnovelP111L0.11
OVchr1768043205Frame_Shift_InsnovelR258Pfs*160.15
OVchr1768042292SilentnovelL170L0.17
OVchr1768043165SilentnovelP244P0.03
OVchr1768042239Missense_MutationnovelE153Q0.04
OVchr1768044366Missense_MutationnovelY404N0.06
OVchr1768043104Missense_MutationnovelG224V0.07
OVchr1768042201Missense_MutationnovelS140F0.07
READchr1768044497SilentNAI447I0.11
READchr1768044048Missense_MutationnovelF381V0.09
SARCchr1768045872Missense_MutationnovelS483F0.18
SARCchr1768045821Missense_MutationnovelE466A0.33
SKCMchr1768037451Missense_MutationnovelP57S0.48
SKCMchr1768044343Missense_MutationNAE396A0.26
SKCMchr1768045887Missense_Mutationrs781870365S488L0.32
SKCMchr1768037387SilentNAN35N0.54
SKCMchr1768042146Missense_MutationNAP122S0.46
SKCMchr17680371165'UTRnovel0.39
SKCMchr1768040746SilentNAL94L0.28
SKCMchr1768044497SilentNAI447I0.05
SKCMchr1768043205Missense_MutationNAR258W0.37
SKCMchr1768043319Missense_MutationNAP296S0.16
STADchr1768044357Missense_Mutationrs782484137V401M0.08
STADchr1768037456SilentNAD58D0.09
STADchr1768043286Nonsense_MutationNAR285*0.18
STADchr1768037481Missense_MutationNAN67H0.33
STADchr1768042287Missense_MutationNAS169P0.34
STADchr1768044032Frame_Shift_DelnovelH376Pfs*90.06
STADchr1768037199Missense_Mutationrs183061920D23H0.22
STADchr1768040746SilentNAL94L0.18
STADchr1768044484Missense_MutationNAA443V0.12
THCAchr1768044318Splice_Regionnovel0.41
UCECchr1768037434Missense_MutationNAR51I0.24
UCECchr1768043112Missense_Mutationrs782396125R227C0.45
UCECchr17680466093'UTRnovel0.51
UCECchr1768043206Missense_Mutationrs374149935R258Q0.46
UCECchr1768037417Missense_MutationnovelD45E0.45
UCECchr1768044497SilentnovelI447I0.23
UCECchr1768043146Missense_MutationnovelR238H0.38
UCECchr1768045896Missense_MutationnovelL491S0.39
UCECchr1768044061Missense_MutationnovelV385A0.32
UCECchr1768043975Silentrs374422131T356T0.04
UCECchr1768042109Frame_Shift_InsnovelI112Pfs*20.37
UCECchr1768046521Silentrs782305218N505N0.27
UCECchr1768044350Silentrs1136736V398V0.32
UCECchr1768043131Missense_MutationNAL233H0.04
UCECchr1768045912Missense_MutationNAF496L0.68
UCECchr1768045791Missense_MutationnovelE456G0.04
UCECchr1768045912Missense_MutationNAF496L0.33
UCECchr1768037472SilentnovelL64L0.17
UCECchr17680466033'UTRnovel0.27
UCECchr1768044393Missense_MutationnovelI413L0.38
UCECchr1768037178Nonsense_MutationnovelR16*0.39
UCECchr1768042293SilentnovelL171L0.42
UCECchr17680466323'UTRrs10594240.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.38970.00012456
COADAMP0.18180.00359
KIRPAMP0.66670.14801
LGGAMP0.06241.52e-05
READAMP0.18790.15915
SARCAMP0.23350.032181
THCADEL0.0020.221
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
THYM0.0082

Kaplan-Meier Survival Analysis

KIRC0.0044

Kaplan-Meier Survival Analysis

STAD0.026

Kaplan-Meier Survival Analysis

SARC0.029

Kaplan-Meier Survival Analysis

MESO0.00011

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

HNSC0.0062

Kaplan-Meier Survival Analysis

SKCM0.00077

Kaplan-Meier Survival Analysis

KIRP0.00013

Kaplan-Meier Survival Analysis

COAD0.00032

Kaplan-Meier Survival Analysis

PAAD0.017

Kaplan-Meier Survival Analysis

PCPG0.048

Kaplan-Meier Survival Analysis

BLCA0.0071

Kaplan-Meier Survival Analysis

READ0.026

Kaplan-Meier Survival Analysis

KICH0.0068

Kaplan-Meier Survival Analysis

UCEC0.026

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

CHOL0.014

Kaplan-Meier Survival Analysis

LUAD0.00011

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000182481 (Gene tree)
Gene ID
3838
Gene Symbol
KPNA2
Alias
SRP1alpha|IPOA1|QIP2|RCH1
Full Name
karyopherin subunit alpha 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
11,336 bases
Position
chr17:68,035,519-68,046,854
Accession
6395
RBP type
non-canonical RBP
Summary
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
8777717Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.Immunity1995 DecSpanopoulou E-
15342649AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR.J Biol Chem2004 Nov 12Wang W-
17919121Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1.Biochem J2008 Jan 15Zou T-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000583269KPNA2-205611-ENSP0000046332050 (aa)-J3QL07
ENST00000582898KPNA2-204394--- (aa)--
ENST00000579754KPNA2-203569-ENSP00000462331143 (aa)-J3KS65
ENST00000537025KPNA2-2022456-ENSP00000438483529 (aa)-P52292
ENST00000583392KPNA2-206507--- (aa)--
ENST00000584026KPNA2-207561-ENSP00000463602134 (aa)-J3QLL0
ENST00000330459KPNA2-2012181-ENSP00000332455529 (aa)-P52292
Gene Model
Click here to download ENSG00000182481's gene model file
Pathways
Pathway IDPathway NameSource
hsa05164Influenza AKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000182481Alcoholism5.86989e-00522978509
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000182481rs620846901768039295ASelf-reported math ability30038396[0.0098-0.018] unit increase0.0139EFO_0004875
ENSG00000182481rs620846931768039994?Lung function (FEV1/FVC)30595370EFO_0004713
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182481's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000182481KPNA29538.077WBGene00002073ima-29738.077Caenorhabditis_elegans
ENSG00000182481KPNA210094.518ENSMUSG00000018362Kpna210095.294Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000018regulation of DNA recombination8016130.TASProcess
GO:0003723RNA binding22681889.HDAFunction
GO:0005515protein binding9168958.9405152.9497340.10353244.10523667.10980193.11024021.11971900.12551970.15507604.15870280.15942031.17324944.19668212.19883659.20551905.20701745.20965181.21385873.21988832.24965446.25416956.25556234.25609649.26420826.26496610.29042515.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm7754385.TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006259DNA metabolic process9168958.TASProcess
GO:0006607NLS-bearing protein import into nucleus17324944.IDAProcess
GO:0008139nuclear localization sequence binding17324944.IDAFunction
GO:0008565protein transporter activity-IEAFunction
GO:0016020membrane19946888.HDAComponent
GO:0019054modulation by virus of host process-TASProcess
GO:0042826histone deacetylase binding10869435.IPIFunction
GO:0043657host cell-IEAComponent
GO:0061608nuclear import signal receptor activity-IEAFunction
GO:0075506entry of viral genome into host nucleus through nuclear pore complex via importin28189564.IMPProcess
GO:0098892extrinsic component of postsynaptic specialization membrane15603742.IDAComponent
GO:0098978glutamatergic synapse15603742.EXPComponent
GO:0098978glutamatergic synapse15603742.IDAComponent
GO:0099527postsynapse to nucleus signaling pathway15603742.EXPProcess
GO:0099527postsynapse to nucleus signaling pathway15603742.IDAProcess
GO:1903902positive regulation of viral life cycle28189564.IMPProcess
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