EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	20748043	3'UTR	novel		0.08
BRCA	chr14	20747895	Missense_Mutation	novel	C105W	0.11	RnaseA
BRCA	chr14	20747672	Missense_Mutation	NA	R31K	0.16	RnaseA
BRCA	chr14	20747926	Missense_Mutation	NA	E116K	0.16	RnaseA
BRCA	chr14	20747946	Silent	NA	Y122Y	0.15
BRCA	chr14	20747955	Missense_Mutation	NA	F125L	0.13	RnaseA
BRCA	chr14	20748007	Missense_Mutation	novel	E143Q	0.57
CESC	chr14	20747904	Missense_Mutation	NA	E108D	0.15	RnaseA
CESC	chr14	20748041	3'UTR	novel		0.33
CESC	chr14	20747834	Missense_Mutation	novel	G85E	0.23	RnaseA
COAD	chr14	20747752	Nonsense_Mutation	novel	E58*	0.45	RnaseA
COAD	chr14	20748218	3'UTR	novel		0.38
COAD	chr14	20748167	3'UTR	rs544677759		0.09
COAD	chr14	20748249	3'UTR	novel		0.07
COAD	chr14	20748168	3'UTR	novel		0.04
DLBC	chr14	20748377	3'UTR	novel		0.26
ESCA	chr14	20748378	3'UTR	novel		0.58
ESCA	chr14	20748181	3'UTR	novel		0.37
GBM	chr14	20747843	Missense_Mutation	rs199609364	R88Q	0.44	RnaseA
GBM	chr14	20747984	Missense_Mutation	NA	N135T	0.45
GBM	chr14	20747785	Missense_Mutation	novel	I69L	0.24	RnaseA
HNSC	chr14	20747813	Missense_Mutation	rs149270684	R78H	0.14	RnaseA
KIRP	chr14	20747812	Frame_Shift_Ins	novel	*R78Pfs53**	0.52	RnaseA
KIRP	chr14	20747813	Frame_Shift_Ins	novel	*A79Mfs52**	0.54	RnaseA
LIHC	chr14	20747827	Missense_Mutation	novel	E83K	0.27	RnaseA
LIHC	chr14	20748345	3'UTR	novel		0.37
LUAD	chr14	20748024	Nonstop_Mutation	novel	148Yext89	0.07
LUAD	chr14	20748121	3'UTR	novel		0.28
LUAD	chr14	20748054	3'UTR	novel		0.3
PAAD	chr14	20747701	Missense_Mutation	novel	P41S	0.17	RnaseA
PRAD	chr14	20747709	Silent	NA	R43R	0.33
READ	chr14	20747843	Missense_Mutation	rs199609364	R88Q	0.26	RnaseA
SARC	chr14	20748116	3'UTR	novel		0.19
SKCM	chr14	20747843	Missense_Mutation	rs199609364	R88Q	0.5	RnaseA
SKCM	chr14	20747928	Silent	NA	E116E	0.24
SKCM	chr14	20747776	Missense_Mutation	NA	H66Y	0.18	RnaseA
SKCM	chr14	20747964	Silent	rs759499952	G128G	0.1
SKCM	chr14	20747708	Missense_Mutation	rs544246375	R43Q	0.92	RnaseA
SKCM	chr14	20747719	Missense_Mutation	NA	E47K	0.4	RnaseA
SKCM	chr14	20747719	Missense_Mutation	NA	E47K	0.37	RnaseA
SKCM	chr14	20747843	Missense_Mutation	rs199609364	R88Q	0.46	RnaseA
SKCM	chr14	20748113	3'UTR	novel		0.47
SKCM	chr14	20747890	Missense_Mutation	rs779330097	E104K	0.23	RnaseA
SKCM	chr14	20747892	Silent	NA	E104E	0.27
STAD	chr14	20747912	Missense_Mutation	NA	N111S	0.37	RnaseA
STAD	chr14	20747876	Missense_Mutation	NA	A99V	0.28	RnaseA
UCEC	chr14	20747984	Missense_Mutation	NA	N135T	0.35
UCEC	chr14	20747997	Silent	novel	L139L	0.31
UCEC	chr14	20748274	3'UTR	novel		0.35
UCEC	chr14	20747787	Silent	novel	I69I	0.43
UCEC	chr14	20748229	3'UTR	novel		0.51
UCEC	chr14	20747957	Missense_Mutation	novel	H126L	0.09	RnaseA
UCEC	chr14	20747958	Frame_Shift_Ins	novel	*C127Sfs9**	0.09	RnaseA
UCEC	chr14	20747958	Frame_Shift_Ins	novel	*C127Sfs9**	0.09	RnaseA
UCEC	chr14	20747957	Missense_Mutation	novel	H126L	0.09	RnaseA
UCEC	chr14	20747958	Frame_Shift_Ins	novel	*C127Sfs9**	0.09	RnaseA
UCEC	chr14	20747687	Missense_Mutation	NA	L36R	0.41	RnaseA
UCEC	chr14	20747889	Silent	NA	L103L	0.39
UCEC	chr14	20748200	3'UTR	novel		0.38
UCEC	chr14	20748316	3'UTR	novel		0.35
UCEC	chr14	20748167	3'UTR	rs544677759		0.18
UCEC	chr14	20747815	Missense_Mutation	rs115258284	A79T	0.28	RnaseA
UCEC	chr14	20747968	Missense_Mutation	novel	D130Y	0.6
UCEC	chr14	20748297	3'UTR	novel		0.55
UCEC	chr14	20748156	3'UTR	novel		0.33
UCEC	chr14	20747890	Missense_Mutation	rs779330097	E104K	0.27	RnaseA
UCEC	chr14	20748285	3'UTR	rs148591991		0.12
UCEC	chr14	20747747	Frame_Shift_Del	novel	*E58Rfs3**	0.18	RnaseA
UCEC	chr14	20747707	Nonsense_Mutation	rs138978934	R43*	0.2	RnaseA
UCEC	chr14	20747889	Silent	NA	L103L	0.35
UCEC	chr14	20747580	5'UTR	novel		0.55
UCEC	chr14	20747771	Missense_Mutation	rs372769674	S64N	0.51	RnaseA
UCEC	chr14	20747588	Missense_Mutation	novel	S3Y	0.24
UCEC	chr14	20748274	3'UTR	novel		0.22
UCEC	chr14	20748174	3'UTR	novel		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2667	0.056464
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1073	0.0025503
KIRP	DEL	0.1632	0.085174
LUSC	DEL	0.2615	0.0082553
PAAD	DEL	0.0924	0.11332
READ	DEL	0.3697	0.0043084

Survival Analysis

Cancer	P-value	Q-value
BRCA	0.018	Kaplan-Meier Survival Analysis
KIRP	0.05	Kaplan-Meier Survival Analysis
KICH	0.019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000181562 (Gene tree)
Gene ID: 10876
Gene Symbol: EDDM3A
Alias: HE3-ALPHA|FAM12A
Full Name: epididymal protein 3A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 2,489 bases
Position: chr14:20,745,892-20,748,380
Accession: 16978
RBP type: canonical RBP
Summary: Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000315098	RnaseA	PF00074.20	1.1e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000326842	EDDM3A-201	927	XM_017020934	ENSP00000315098	147 (aa)	XP_016876423	Q14507

Gene Model

Click here to download ENSG00000181562's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000181562	Body Height	9.0710000E-006	-
ENSG00000181562	Body Height	7.7010000E-006	-
ENSG00000181562	Body Height	5.7560000E-005	-
ENSG00000181562	Body Height	4.9990000E-005	-
ENSG00000181562	Waist-Hip Ratio	9.7210000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181562's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181562	EDDM3A	97	48.951	ENSAMEG00000019906	-	98	48.951	Ailuropoda_melanoleuca
ENSG00000181562	EDDM3A	88	49.231	ENSBTAG00000055081	-	88	48.800	Bos_taurus
ENSG00000181562	EDDM3A	100	86.395	ENSCJAG00000040222	EDDM3A	100	81.633	Callithrix_jacchus
ENSG00000181562	EDDM3A	100	70.068	ENSCJAG00000038288	EDDM3B	100	70.068	Callithrix_jacchus
ENSG00000181562	EDDM3A	97	48.951	ENSCAFG00000005429	-	98	48.951	Canis_familiaris
ENSG00000181562	EDDM3A	97	48.951	ENSCAFG00020014402	-	88	48.951	Canis_lupus_dingo
ENSG00000181562	EDDM3A	100	71.429	ENSCATG00000022830	EDDM3B	100	71.429	Cercocebus_atys
ENSG00000181562	EDDM3A	100	88.435	ENSCSAG00000000348	EDDM3A	100	88.435	Chlorocebus_sabaeus
ENSG00000181562	EDDM3A	100	71.429	ENSCSAG00000000347	EDDM3B	100	71.429	Chlorocebus_sabaeus
ENSG00000181562	EDDM3A	99	51.370	ENSCHOG00000011384	-	99	51.370	Choloepus_hoffmanni
ENSG00000181562	EDDM3A	100	70.068	ENSCANG00000038286	EDDM3B	100	70.068	Colobus_angolensis_palliatus
ENSG00000181562	EDDM3A	99	49.655	ENSCGRG00001015047	Eddm3b	95	50.345	Cricetulus_griseus_chok1gshd
ENSG00000181562	EDDM3A	75	51.818	ENSDNOG00000041158	-	100	51.818	Dasypus_novemcinctus
ENSG00000181562	EDDM3A	99	53.103	ENSDORG00000023401	Eddm3b	95	53.103	Dipodomys_ordii
ENSG00000181562	EDDM3A	96	43.972	ENSETEG00000011239	-	76	47.748	Echinops_telfairi
ENSG00000181562	EDDM3A	100	54.422	ENSEASG00005002956	-	90	54.422	Equus_asinus_asinus
ENSG00000181562	EDDM3A	100	54.422	ENSECAG00000028388	-	90	54.422	Equus_caballus
ENSG00000181562	EDDM3A	99	51.724	ENSEEUG00000004950	-	99	51.724	Erinaceus_europaeus
ENSG00000181562	EDDM3A	97	53.147	ENSFCAG00000013772	-	98	53.147	Felis_catus
ENSG00000181562	EDDM3A	100	98.639	ENSGGOG00000016754	EDDM3A	100	98.639	Gorilla_gorilla
ENSG00000181562	EDDM3A	100	70.068	ENSGGOG00000011563	EDDM3B	100	70.068	Gorilla_gorilla
ENSG00000181562	EDDM3A	99	44.828	ENSLAFG00000023121	-	99	44.828	Loxodonta_africana
ENSG00000181562	EDDM3A	100	48.299	ENSLAFG00000001699	-	100	48.299	Loxodonta_africana
ENSG00000181562	EDDM3A	100	70.068	ENSMMUG00000001656	EDDM3B	100	70.068	Macaca_mulatta
ENSG00000181562	EDDM3A	100	71.429	ENSMLEG00000027313	EDDM3B	100	71.429	Mandrillus_leucophaeus
ENSG00000181562	EDDM3A	84	39.837	ENSMODG00000024492	-	81	39.837	Monodelphis_domestica
ENSG00000181562	EDDM3A	99	50.345	MGP_CAROLIEiJ_G0019218	Eddm3b	95	50.345	Mus_caroli
ENSG00000181562	EDDM3A	99	50.345	ENSMUSG00000072575	Eddm3b	95	50.345	Mus_musculus
ENSG00000181562	EDDM3A	99	51.034	MGP_SPRETEiJ_G0020111	Eddm3b	95	51.034	Mus_spretus
ENSG00000181562	EDDM3A	97	50.350	ENSMPUG00000018383	-	98	50.350	Mustela_putorius_furo
ENSG00000181562	EDDM3A	99	53.425	ENSMLUG00000014174	-	96	53.425	Myotis_lucifugus
ENSG00000181562	EDDM3A	100	67.347	ENSNLEG00000034277	-	100	67.347	Nomascus_leucogenys
ENSG00000181562	EDDM3A	100	68.707	ENSNLEG00000029047	-	100	68.707	Nomascus_leucogenys
ENSG00000181562	EDDM3A	80	38.462	ENSMEUG00000015068	-	83	38.462	Notamacropus_eugenii
ENSG00000181562	EDDM3A	99	43.836	ENSOPRG00000013117	-	85	44.000	Ochotona_princeps
ENSG00000181562	EDDM3A	99	55.172	ENSOCUG00000026377	-	95	55.172	Oryctolagus_cuniculus
ENSG00000181562	EDDM3A	100	62.585	ENSOGAG00000007767	-	100	62.585	Otolemur_garnettii
ENSG00000181562	EDDM3A	100	51.020	ENSOARG00000012827	-	100	51.020	Ovis_aries
ENSG00000181562	EDDM3A	99	50.000	ENSOARG00000012492	-	96	50.000	Ovis_aries
ENSG00000181562	EDDM3A	100	69.388	ENSPPAG00000033003	EDDM3B	100	69.388	Pan_paniscus
ENSG00000181562	EDDM3A	100	98.639	ENSPPAG00000000145	EDDM3A	100	98.639	Pan_paniscus
ENSG00000181562	EDDM3A	97	51.748	ENSPPRG00000020024	-	98	51.748	Panthera_pardus
ENSG00000181562	EDDM3A	97	50.350	ENSPTIG00000004120	-	98	50.350	Panthera_tigris_altaica
ENSG00000181562	EDDM3A	100	98.639	ENSPTRG00000006102	EDDM3A	100	98.639	Pan_troglodytes
ENSG00000181562	EDDM3A	100	69.388	ENSPTRG00000006103	EDDM3B	100	69.388	Pan_troglodytes
ENSG00000181562	EDDM3A	100	71.429	ENSPANG00000007680	EDDM3B	100	71.429	Papio_anubis
ENSG00000181562	EDDM3A	99	46.207	ENSPEMG00000014380	Eddm3b	95	46.207	Peromyscus_maniculatus_bairdii
ENSG00000181562	EDDM3A	84	38.710	ENSPCIG00000028761	-	78	38.710	Phascolarctos_cinereus
ENSG00000181562	EDDM3A	100	97.279	ENSPPYG00000005575	EDDM3A	100	97.279	Pongo_abelii
ENSG00000181562	EDDM3A	100	69.388	ENSPPYG00000005576	EDDM3B	100	69.388	Pongo_abelii
ENSG00000181562	EDDM3A	100	53.741	ENSPVAG00000013560	-	100	53.741	Pteropus_vampyrus
ENSG00000181562	EDDM3A	97	50.350	ENSRNOG00000052100	Eddm3b	80	52.174	Rattus_norvegicus
ENSG00000181562	EDDM3A	97	50.350	ENSRNOG00000054022	LOC103693384	80	52.174	Rattus_norvegicus
ENSG00000181562	EDDM3A	97	50.350	ENSRNOG00000030110	LOC103693823	80	52.174	Rattus_norvegicus
ENSG00000181562	EDDM3A	100	71.429	ENSRROG00000037495	EDDM3B	100	71.429	Rhinopithecus_roxellana
ENSG00000181562	EDDM3A	99	40.411	ENSSHAG00000006060	-	80	41.803	Sarcophilus_harrisii
ENSG00000181562	EDDM3A	99	50.685	ENSSSCG00000021866	EDDM3B	99	50.685	Sus_scrofa
ENSG00000181562	EDDM3A	100	50.676	ENSVPAG00000007373	-	100	50.676	Vicugna_pacos
ENSG00000181562	EDDM3A	97	49.650	ENSVVUG00000009061	-	87	50.000	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005615	extracellular space	7514008.	TAS	Component
GO:0007321	sperm displacement	7514008.	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.