EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23349811p68/DdX5 supports β-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.PLoS One2013Clark ELdoi: 10.1371/journal.pone.0054150
28027311Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution.PLoS Genet2016 Dec 27Van den Eynden Jdoi: 10.1371/journal.pgen.1006506
28922562Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer.Thorac Cancer2017 NovYoo SSdoi: 10.1111/1759-7714.12478

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr177513535In_Frame_InsnovelS1768_P1774dup0.18
BLCAchr177509063SilentnovelV1195V0.1
BLCAchr177497751SilentnovelF361F0.52
BLCAchr177498082Missense_MutationnovelQ403E0.63
BLCAchr177496553SilentnovelE159E0.46
BLCAchr177502002Missense_MutationnovelE818Q0.55
BLCAchr177503674Missense_MutationnovelF1041L0.14
BLCAchr177511221Missense_MutationnovelE1274Q0.27
BLCAchr177512218Nonsense_MutationnovelE1456*0.12
BLCAchr177509040Missense_MutationnovelE1188K0.49
BLCAchr177502100SilentnovelT850T0.3
BLCAchr177501550Missense_MutationnovelE724K0.08
BLCAchr177512307SilentnovelE1485E0.46
BLCAchr177497730SilentnovelL354L0.84
BLCAchr177503184Missense_MutationnovelK940N0.85
BLCAchr177499474Missense_MutationnovelD552N0.45
BLCAchr177514149Nonsense_MutationnovelS1962*0.34
BLCAchr177509145Missense_MutationnovelD1223N0.62
BLCAchr177501698Missense_MutationnovelG773E0.59
BRCAchr1775144013'UTRNA0.37
BRCAchr177511431Missense_MutationnovelD1315A0.06
BRCAchr177508953Missense_MutationnovelC1159R0.28
BRCAchr177496783Missense_Mutationrs139873836R186Q0.46RNA_pol_Rpb1_2
BRCAchr177502540Missense_Mutationrs201063777I865M0.42
BRCAchr177500951SilentnovelE631E0.33
BRCAchr177513643Frame_Shift_InsnovelS1794Lfs*1310.07
BRCAchr177513084Missense_MutationnovelG1607V0.1
BRCAchr177509142Missense_MutationnovelT1222A0.93
BRCAchr177500991Missense_MutationnovelL645V0.06
BRCAchr177503746Silentrs745614130F1065F0.43
BRCAchr177499575Intronnovel0.43
BRCAchr177509031Missense_MutationnovelV1185L0.11
CESCchr177503125Missense_MutationnovelR921C0.5
CESCchr177500671Silentrs765136696S568S0.32
CESCchr177501911Silentrs369411244V787V0.39
CESCchr177496912Missense_MutationnovelS229L0.71RNA_pol_Rpb1_2
CESCchr177497787SilentnovelL373L0.3
CESCchr177503768Missense_MutationnovelE1073Q0.32
CESCchr177503393SilentnovelL979L0.09
CESCchr177496568Silentrs368365915F164F0.35
CESCchr177511971Missense_MutationnovelR1421H0.17
CESCchr177512476Splice_SitenovelX1498_splice0.14
CESCchr177512882Missense_Mutationrs754812578P1572L0.4
CESCchr177513072Missense_MutationnovelR1603H0.12
CESCchr1775145093'UTRnovel0.31
CESCchr177513495Missense_MutationnovelT1744I0.18
CESCchr177513137Missense_MutationnovelT1625A0.37
CESCchr177508423Missense_Mutationrs771125580S1138L0.07
CESCchr177512325Silentrs768349650P1491P0.15
CESCchr177484835Missense_MutationnovelG24A0.4RNA_pol_Rpb1_2
CESCchr177513604SilentnovelS1780S0.43
CESCchr177498201Silentrs146006267T442T0.66
COADchr177512883Silentrs199766347P1572P0.53
COADchr177513153Missense_MutationnovelS1630Y0.4
COADchr177499400Frame_Shift_DelnovelQ529Rfs*320.18
COADchr177496870Missense_MutationnovelL215R0.4RNA_pol_Rpb1_2
COADchr177503707SilentnovelR1052R0.25
COADchr177509063SilentnovelV1195V0.34
COADchr177509588Missense_MutationnovelL1257F0.41
COADchr177500999SilentnovelT647T0.35
COADchr177499400Frame_Shift_DelnovelQ529Rfs*320.31
COADchr177514110Missense_Mutationrs775355170R1949H0.29
COADchr177501364Missense_MutationnovelA709V0.11
COADchr177497773Missense_MutationnovelP369T0.44
COADchr177512482Missense_MutationnovelG1500C0.48
COADchr177509041Missense_MutationnovelE1188G0.29
COADchr177512901SilentnovelS1578S0.29
COADchr177498120Silentrs769941878G415G0.18
COADchr177513958SilentnovelQ1898Q0.81
COADchr177511960Silentrs774135346H1417H0.18
COADchr177514025Frame_Shift_DelnovelP1922Qfs*440.45
COADchr177495969Missense_MutationnovelI41T0.09RNA_pol_Rpb1_2
COADchr177514193Missense_MutationnovelA1977T0.39
COADchr177502007SilentnovelS819S0.07
COADchr177498121Missense_Mutationrs763272826A416T0.11
DLBCchr177513036Missense_Mutationrs774093039P1591L0.31
ESCAchr177511955Nonsense_MutationnovelR1416*0.17
GBMchr177513900Frame_Shift_DelnovelV1879Afs*350.48
GBMchr177514128Missense_MutationnovelT1955K0.17
GBMchr177496895Missense_MutationnovelE223D0.2RNA_pol_Rpb1_2
GBMchr177497713Missense_MutationnovelR349W0.37RNA_pol_Rpb1_2
GBMchr177512210Missense_MutationnovelG1453E0.34
GBMchr177499111Missense_MutationnovelM470L0.25
GBMchr177500960SilentnovelE634E0.35
GBMchr177503218Missense_MutationnovelL952V0.07
GBMchr177511547Missense_MutationnovelP1354T0.41
GBMchr177499377SilentnovelA519A0.15
GBMchr177500729Missense_MutationnovelG588R0.09
HNSCchr177500811Missense_MutationnovelS615N0.93
HNSCchr177509103Missense_MutationnovelP1209S0.23
HNSCchr177500828Missense_MutationnovelI621V0.26
HNSCchr177496221Missense_MutationnovelE80Q0.1RNA_pol_Rpb1_2
HNSCchr177511460Missense_MutationnovelD1325H0.11
HNSCchr177499596Intronnovel0.29
HNSCchr177503269Missense_MutationnovelI969V0.21
HNSCchr177512181Silentrs201531764A1443A0.33
HNSCchr177496307SilentnovelR108R0.16
HNSCchr177498088Missense_MutationnovelL405V0.07
HNSCchr177495999Missense_MutationnovelR51P0.23RNA_pol_Rpb1_2
HNSCchr177513498Missense_MutationnovelS1745N0.71
HNSCchr177511474Silentrs764911266K1329K0.23
HNSCchr177513710Missense_MutationnovelP1816A0.34
KICHchr177497407Missense_Mutationrs201628232R291W0.1RNA_pol_Rpb1_2
KIRCchr177502093Missense_MutationnovelI848T0.12
KIRCchr177499560Intronnovel0.5
KIRCchr177513294Missense_MutationnovelS1677N0.17
KIRCchr177499070Missense_MutationnovelV456G0.05
KIRCchr177501098Frame_Shift_DelnovelL681Sfs*330.27
KIRCchr177513799Silentrs564268404L1845L0.21
KIRPchr177513941In_Frame_Delrs745782731L1895del0.19
KIRPchr177496025Missense_MutationnovelP60A0.34RNA_pol_Rpb1_2
KIRPchr177501681SilentnovelK767K0.24
LAMLchr177496009Frame_Shift_InsnovelL57Afs*100.1RNA_pol_Rpb1_2
LGGchr177511560Missense_MutationnovelT1358M0.22
LGGchr177512512Missense_MutationnovelM1510L0.42
LGGchr177501685Missense_MutationnovelM769V0.08
LGGchr177496546Missense_MutationnovelG157V0.08RNA_pol_Rpb1_2
LGGchr177501959Missense_MutationnovelK803N0.32
LGGchr177509613Missense_MutationnovelD1265V0.09
LIHCchr177513731In_Frame_Delrs770798456S1828_P1834del0.46
LIHCchr177497657Missense_MutationnovelQ330L0.26RNA_pol_Rpb1_2
LIHCchr177501567Silentrs140982359P729P0.36
LIHCchr177501568Missense_MutationnovelG730W0.37
LUADchr177501996Missense_MutationnovelG816W0.68
LUADchr177502533Missense_MutationnovelR863L0.12
LUADchr177502534Silentrs148495191R863R0.12
LUADchr177514195SilentnovelA1977A0.58
LUADchr177501685Missense_MutationnovelM769V0.19
LUADchr177508286SilentnovelA1092A0.54
LUADchr177498098Frame_Shift_DelnovelN410Tfs*600.23
LUADchr177497479Missense_MutationnovelA315S0.37RNA_pol_Rpb1_2
LUADchr177513985SilentnovelL1907L0.18
LUADchr177512495Missense_MutationnovelG1504V0.73
LUADchr177503463Missense_MutationnovelD1003N0.21
LUADchr177499056SilentnovelC451C0.73
LUADchr177513368Missense_MutationnovelT1702S0.46
LUADchr177514134Nonsense_MutationnovelS1957*0.24
LUADchr177501598Nonsense_MutationnovelV741*0.06
LUADchr177501600Nonsense_MutationnovelV741Rfs*20.05
LUADchr177501020SilentnovelH654H0.1
LUADchr177503237Missense_MutationnovelR958P0.25
LUADchr177513369Missense_MutationnovelT1702I0.2
LUSCchr177511879Silentrs780224204G1390G0.06
LUSCchr177514168SilentnovelT1968T0.35
LUSCchr177513459Missense_MutationnovelP1732L0.51
LUSCchr177503237Missense_Mutationrs565133398R958Q0.21
LUSCchr177513645Nonsense_MutationnovelS1794*0.51
LUSCchr177509544Missense_MutationnovelD1242G0.38
LUSCchr177509148Missense_MutationnovelR1224W0.34
LUSCchr177513836Missense_MutationnovelL1858V0.36
LUSCchr177503777Missense_MutationnovelF1076L0.39
LUSCchr177512325Silentrs768349650P1491P0.65
LUSCchr177502043SilentnovelL831L0.38
LUSCchr177511874Missense_MutationnovelD1389H0.25
LUSCchr177503694Missense_Mutationrs755560039T1048M0.61
LUSCchr177501613Missense_MutationnovelL745V0.18
MESOchr177496009Frame_Shift_InsnovelL57Afs*100.17RNA_pol_Rpb1_2
MESOchr177511925Missense_MutationnovelT1406A0.05
MESOchr177499573Intronnovel0.24
OVchr177511911Missense_MutationnovelL1401W0.07
OVchr177512877SilentnovelG1570G0.35
OVchr177513810Missense_MutationnovelP1849R0.77
OVchr177499625Intronnovel0.44
OVchr177511903Missense_MutationnovelL1398F0.36
OVchr177508272Missense_MutationnovelG1088R0.15
PAADchr177513679SilentnovelS1805S0.12
PAADchr177502575Missense_MutationnovelA877V0.04
PAADchr177503247Missense_MutationnovelE961D0.17
PAADchr177514125Missense_MutationnovelP1954H0.04
PCPGchr177513717Missense_MutationnovelY1818C0.43
PRADchr177502081Missense_MutationnovelR844H0.13
PRADchr177501039Missense_MutationnovelG661S0.43
READchr177502022Missense_MutationnovelE824D0.19
READchr177513624Missense_MutationnovelS1787F0.25
READchr177508466SilentnovelE1152E0.16
READchr177496055Missense_MutationnovelR70C0.71RNA_pol_Rpb1_2
READchr177495951Missense_MutationnovelS35Y0.25RNA_pol_Rpb1_2
READchr177496568Silentrs368365915F164F0.33
READchr177508404Missense_MutationnovelK1132E0.35
READchr177513196Silentrs200514677S1644S0.43
READchr177513503Missense_MutationnovelN1747D0.12
SARCchr177502640Missense_MutationnovelE899K0.73
SKCMchr177513953Missense_MutationnovelP1897S0.47
SKCMchr177496002Missense_MutationnovelP52L0.49RNA_pol_Rpb1_2
SKCMchr177509101Missense_MutationnovelS1208F0.38
SKCMchr177498132SilentnovelI419I0.4
SKCMchr177513554Missense_MutationnovelP1764S0.36
SKCMchr177513584Missense_MutationnovelP1774S0.31
SKCMchr177513083Missense_MutationnovelG1607C0.25
SKCMchr177501911Silentrs369411244V787V0.89
SKCMchr177503457Missense_Mutationrs754080145P1001S0.22
SKCMchr177513155Missense_MutationnovelP1631S0.27
SKCMchr177513156Missense_MutationnovelP1631L0.26
SKCMchr177513478Silentrs142175837S1738S0.27
SKCMchr177513112SilentnovelS1616S0.36
SKCMchr177499106Missense_MutationnovelS468F0.3
SKCMchr177508419Missense_MutationnovelP1137S0.21
SKCMchr177501010Missense_MutationnovelS651F0.35
SKCMchr177514095Missense_MutationnovelL1944P0.51
SKCMchr177514097Missense_MutationnovelP1945S0.49
SKCMchr177513501Missense_Mutationrs779849342P1746L0.43
SKCMchr177499135Missense_MutationnovelP478S0.32
SKCMchr177503487Missense_MutationnovelE1011K0.37
SKCMchr177502080Missense_MutationnovelR844C0.81
SKCMchr177513522Missense_MutationnovelP1753L0.82
SKCMchr177498142Missense_MutationnovelN423Y0.42
SKCMchr177512875Missense_MutationnovelG1570S0.27
SKCMchr177501026SilentnovelS656S0.11
SKCMchr177511828Silentrs764110481A1373A0.32
SKCMchr177499291Missense_MutationnovelP491S0.14
SKCMchr177498168SilentnovelF431F0.45
SKCMchr177497472SilentnovelF312F0.18
SKCMchr177512787SilentnovelT1540T0.32
SKCMchr177497003Silentrs142508418S259S0.68
SKCMchr177514058Missense_MutationnovelR1932C0.56
SKCMchr177499482Silentrs752556134F554F0.29
SKCMchr177496893Missense_MutationnovelE223K0.41RNA_pol_Rpb1_2
SKCMchr177512311Missense_MutationnovelP1487S0.2
SKCMchr177497682SilentnovelS338S0.25
SKCMchr177512223Missense_MutationnovelN1457K0.33
SKCMchr177503457Missense_Mutationrs754080145P1001S0.33
SKCMchr177511969SilentnovelN1420N0.69
SKCMchr177512323Missense_MutationnovelP1491T0.39
SKCMchr177498135SilentnovelI420I0.24
STADchr177513785Frame_Shift_DelnovelQ1842Nfs*720.12
STADchr177495957Missense_MutationnovelT37M0.32RNA_pol_Rpb1_2
STADchr177496305Missense_MutationnovelR108C0.19RNA_pol_Rpb1_2
STADchr177513072Missense_MutationnovelR1603H0.25
STADchr177502571Missense_MutationnovelD876N0.35
STADchr177513579Missense_MutationnovelT1772I0.16
STADchr177511237Missense_MutationnovelM1279T0.16
STADchr177512198Missense_MutationnovelD1449G0.26
STADchr177496527Frame_Shift_DelnovelN152Tfs*240.1RNA_pol_Rpb1_2
STADchr177513689Missense_MutationnovelP1809S0.35
STADchr177503409Missense_Mutationrs548638112R985W0.09
STADchr177513072Missense_MutationnovelR1603H0.36
STADchr177496521Missense_MutationnovelK149E0.33RNA_pol_Rpb1_2
STADchr177513490SilentnovelS1742S0.3
STADchr177499065SilentnovelD454D0.34
STADchr177499126Missense_Mutationrs775983104R475C0.32
STADchr177513751Silentrs370656689S1829S0.21
STADchr177501622Missense_MutationnovelA748T0.18
STADchr177496347Splice_SitenovelX121_splice0.28
STADchr177509122Missense_MutationnovelE1215A0.23
STADchr177511500Missense_MutationnovelT1338M0.14
STADchr177503264Missense_MutationnovelR967M0.15
STADchr177513886SilentnovelS1874S0.13
STADchr177498121Missense_Mutationrs763272826A416T0.32
STADchr177503665Silentrs771846320T1038T0.13
STADchr177496880SilentnovelP218P0.33
STADchr177500660Missense_MutationnovelM565V0.38
THCAchr177514080Missense_MutationnovelQ1939P0.1
THCAchr177503729Missense_MutationnovelL1060F0.15
UCECchr177496545Frame_Shift_DelnovelE158Rfs*180.29RNA_pol_Rpb1_2
UCECchr177497771Frame_Shift_DelnovelD370Tfs*190.3
UCECchr177501077Silentrs112363039Q673Q0.36
UCECchr177496885Missense_Mutationrs756676283R220Q0.43RNA_pol_Rpb1_2
UCECchr177501964Missense_MutationnovelR805Q0.38
UCECchr177512182Missense_MutationnovelA1444T0.39
UCECchr177500829Missense_MutationnovelI621T0.03
UCECchr177498201SilentnovelT442T0.45
UCECchr177503294Splice_SitenovelX976_splice0.39
UCECchr177513363Missense_MutationnovelS1700L0.39
UCECchr177511320Splice_SitenovelX1306_splice0.25
UCECchr177498152Missense_MutationnovelR426H0.47
UCECchr177503672Missense_MutationnovelF1041V0.22
UCECchr177508456Missense_MutationnovelR1149Q0.46
UCECchr177513502Silentrs145007034P1746P0.43
UCECchr177499399Frame_Shift_InsnovelQ529Pfs*310.44
UCECchr177499385Missense_MutationnovelP522H0.36
UCECchr177513348Missense_Mutationrs749911689T1695M0.35
UCECchr177499489Missense_MutationnovelR557W0.32
UCECchr177503441Silentrs766259489H995H0.42
UCECchr177509548Missense_MutationnovelL1243F0.1
UCECchr177496555Missense_MutationnovelM160R0.06RNA_pol_Rpb1_2
UCECchr177513890Missense_Mutationrs766202800R1876C0.25
UCECchr177502621Silentrs746718678G892G0.13
UCECchr177511265SilentnovelI1288I0.1
UCECchr177512286SilentnovelE1478E0.2
UCECchr177496301SilentnovelV106V0.36
UCECchr177497358Splice_RegionnovelD274D0.46
UCECchr177500676Missense_MutationnovelW570L0.33
UCECchr177501039Missense_MutationnovelG661S0.21
UCECchr177508462Missense_MutationnovelA1151G0.48
UCECchr177496868SilentnovelI214I0.09
UCECchr177497670SilentnovelR334R0.33
UCECchr177498151Missense_MutationnovelR426C0.45
UCECchr177508464Missense_MutationnovelE1152K0.25
UCECchr177497806Missense_MutationnovelV380M0.32
UCECchr177496286SilentnovelV101V0.12
UCECchr1775145873'UTRnovel0.3
UCECchr177499575Intronnovel0.35
UCECchr177495961Missense_MutationnovelE38D0.38RNA_pol_Rpb1_2
UCECchr177513478Silentrs142175837S1738S0.25
UCECchr177499400Frame_Shift_DelnovelQ529Rfs*320.44
UCECchr177499400Frame_Shift_DelnovelQ529Rfs*320.39
UCECchr177512182Missense_MutationnovelA1444T0.14
UCECchr177499457Missense_Mutationrs759150226R546H0.36
UCECchr177503470Missense_MutationnovelH1005R0.42
UCECchr177503665Silentrs771846320T1038T0.37
UCECchr177512182Missense_MutationnovelA1444T0.51
UCECchr177513617Missense_MutationnovelP1785S0.4
UCECchr177514067Frame_Shift_DelnovelP1936Qfs*300.3
UCECchr177497829SilentnovelN387N0.27
UCECchr177503252Missense_MutationnovelR963Q0.53
UCECchr177503452Missense_MutationnovelR999H0.37
UCECchr177512181Silentrs201531764A1443A0.32
UCECchr177502574Missense_Mutationrs764559155A877T0.23
UCECchr177500999Silentrs768814281T647T0.24
UCECchr177509055Missense_MutationnovelV1193M0.15
UCECchr177496539Missense_MutationnovelE155K0.43RNA_pol_Rpb1_2
UCECchr177511862Missense_MutationnovelV1385I0.33
UCECchr177512490Missense_MutationnovelF1502L0.38
UCECchr177513502Silentrs145007034P1746P0.42
UCECchr177509565Missense_MutationnovelD1249G0.37
UCECchr177511520Missense_Mutationrs142714917R1345W0.18
UCECchr177512182Missense_MutationnovelA1444T0.07
UCECchr177501963Missense_MutationnovelR805W0.31
UCECchr177503126Missense_Mutationrs200835893R921H0.27
UCECchr177503746Silentrs745614130F1065F0.38
UCECchr177497771Frame_Shift_DelnovelD370Tfs*190.37
UCECchr177511284Missense_MutationnovelD1295Y0.46
UCECchr177513467Missense_MutationnovelS1735A0.37
UCECchr1775144173'UTRnovel0.33
UCECchr177511257Missense_MutationnovelR1286C0.43
UCECchr177503159Missense_Mutationrs773630296R932H0.24
UCECchr177496868SilentnovelI214I0.31
UCECchr177498095Missense_Mutationrs141769858R407H0.52
UCECchr177500778Missense_Mutationrs764504201R604H0.35
UCECchr177513800Missense_MutationnovelL1846I0.14
UCECchr177499400Frame_Shift_DelnovelQ529Rfs*320.53
UCECchr177499477Missense_MutationnovelV553I0.31
UCECchr177500660Missense_MutationnovelM565V0.23
UCECchr177503237Missense_Mutationrs565133398R958Q0.44
UCECchr177511554Missense_Mutationrs772421579R1356H0.3
UCECchr177496496SilentnovelR140R0.07
UCECchr177498121Missense_Mutationrs763272826A416T0.24
UCECchr177500778Missense_Mutationrs764504201R604H0.29
UCECchr177501607Missense_MutationnovelR743C0.32
UCECchr177502068Missense_MutationnovelA840T0.2
UCECchr177498209Missense_MutationnovelK445R0.44
UCECchr1775142913'UTRnovel0.09
UCECchr1775142933'UTRnovel0.07
UCECchr177496010Frame_Shift_DelnovelL57*0.14RNA_pol_Rpb1_2
UCECchr177511919Missense_MutationnovelT1404A0.13
UCECchr177508269Missense_MutationnovelV1087M0.4
UCECchr177499400Frame_Shift_DelnovelQ529Rfs*320.28
UCECchr177498085Nonsense_MutationnovelE404*0.3
UCECchr177496825Missense_MutationnovelA200V0.2RNA_pol_Rpb1_2
UCECchr177497451Missense_MutationnovelE305D0.33RNA_pol_Rpb1_2
UCECchr177497806Missense_MutationnovelV380M0.21
UCECchr177499457Missense_Mutationrs759150226R546H0.34
UCECchr177502576SilentnovelA877A0.14
UCECchr177511456Silentrs143101629T1323T0.28
UCECchr177512481Silentrs748257528T1499T0.44
UCECchr177503491Splice_SitenovelX1012_splice0.46
UCECchr177496796Missense_MutationnovelR190S0.14RNA_pol_Rpb1_2
UCECchr177496583SilentnovelP169P0.05
UCECchr177496877SilentnovelS217S0.09
UCECchr177497407Missense_Mutationrs201628232R291W0.27RNA_pol_Rpb1_2
UCECchr177499121Missense_Mutationrs201184176R473Q0.26
UCECchr177501352Missense_MutationnovelT705N0.28
UCECchr177511505Missense_MutationnovelG1340S0.22
UCECchr177495944Nonsense_Mutationrs767064007R33*0.24RNA_pol_Rpb1_2
UCECchr177503231Missense_MutationnovelF956C0.39
UCECchr177513927Missense_MutationnovelN1888T0.38
UCECchr177503200Missense_MutationnovelA946T0.35
UCSchr177511566Missense_Mutationrs769104202N1360S0.85
UCSchr177513836Missense_MutationnovelL1858F0.4
UCSchr177500999Silentrs768814281T647T0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.20830.18166
LAMLDEL0.07330.12511
LIHCDEL0.57573.9592e-10
THCADEL0.0160.221

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.012

Kaplan-Meier Survival Analysis

SKCM0.00011

Kaplan-Meier Survival Analysis

PRAD0.025

Kaplan-Meier Survival Analysis

LIHC0.014

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
Description
Ensembl ID
ENSG00000181222 (Gene tree)
Gene ID
5430
Gene Symbol
POLR2A
Alias
POLRA|RPB1|POLR2
Full Name
RNA polymerase II subunit A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
30,253 bases
Position
chr17:7,484,366-7,514,618
Accession
9187
RBP type
canonical RBP
Summary
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000461879RNA_pol_Rpb1_2PF00623.201.5e-7411
ENSP00000461879RNA_pol_Rpb1_3PF04983.184.9e-0911
ENSP00000461879RNA_pol_Rpb1_1PF04997.122.8e-10911
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23478263Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1.Mol Cell Biol2013 MayBadjatia Ndoi: 10.1128/MCB.00156-13
31123282BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly.Sci Rep2019 May 23Frischknecht Ldoi: 10.1038/s41598-019-44112-7.
17179178Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases.Nucleic Acids Res2007Zaros C-
9325316RNA polymerase II subunits 2, 3, and 11 form a core subassembly with DNA binding activity.J Biol Chem1997 Oct 10Kimura M-
16632472Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases.J Biol Chem2006 Jun 30Kang X-
19711185High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations.J Biomol NMR2009 NovZeng Jdoi: 10.1007/s10858-009-9366-3
18042645Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.Genome Res2008 JanBarrera LO-
22649785The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.Front Oncol2012 Apr 12Zhang Qdoi: 10.3389/fonc.2012.00035
21288871Functional relevance of CpG island length for regulation of gene expression.Genetics2011 AprElango Ndoi: 10.1534/genetics.110.126094
26015065Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.Prostate2015 SepChen Hdoi: 10.1002/pros.23008
29317594Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.Transl Psychiatry2018 Jan 10Naik RRdoi: 10.1038/s41398-017-0025-2.
30994454Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.Elife2019 Apr 17Gao Rdoi: 10.7554/eLife.42988.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000576553POLR2A-206602--- (aa)--
ENST00000575547POLR2A-204702--- (aa)--
ENST00000576952POLR2A-208532--- (aa)--
ENST00000574158POLR2A-203461--- (aa)--
ENST00000576718POLR2A-207548--- (aa)--
ENST00000617998POLR2A-2096751--- (aa)--
ENST00000576114POLR2A-205245--- (aa)--
ENST00000572844POLR2A-2012083-ENSP00000461879566 (aa)-P24928
ENST00000573603POLR2A-202648--- (aa)--
Gene Model
Click here to download ENSG00000181222's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000181222rs8753177514323TNon-glioblastoma glioma26424050[2.39-4.00]3.09EFO_0000326
ENSG00000181222rs6761177514346?Protein quantitative trait loci18464913EFO_0004696
ENSG00000181222rs11658168177502815AHeel bone mineral density30598549[0.012-0.02] unit decrease0.0160772EFO_0009270
ENSG00000181222rs4354991177488305?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000181222rs4239258177493724TMetastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)30738427[18.72-515.88]98.28EFO_0007675|EFO_1001480|EFO_0008336
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181222's network
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000181222POLR2A9637.634ENSG00000148606POLR3A8145.342
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000181222POLR2A10099.823ENSCJAG00000015157POLR2A10099.823Callithrix_jacchus
ENSG00000181222POLR2A9999.113ENSFCAG00000046533POLR2A9999.113Felis_catus
ENSG00000181222POLR2A98100.000ENSGGOG00000014800-54100.000Gorilla_gorilla
ENSG00000181222POLR2A9899.820ENSMFAG00000007042-5799.820Macaca_fascicularis
ENSG00000181222POLR2A9899.820ENSMLEG00000030263-5799.820Mandrillus_leucophaeus
ENSG00000181222POLR2A93100.000ENSMAUG00000021055-53100.000Mesocricetus_auratus
ENSG00000181222POLR2A9899.820ENSMICG00000013372-5699.820Microcebus_murinus
ENSG00000181222POLR2A9597.588ENSOANG00000003303-5797.588Ornithorhynchus_anatinus
ENSG00000181222POLR2A9999.113ENSPPRG00000000743POLR2A9999.113Panthera_pardus
ENSG00000181222POLR2A9995.722ENSPTIG00000005583POLR2A10095.722Panthera_tigris_altaica
ENSG00000181222POLR2A9397.913ENSSPUG00000017777-10097.913Sphenodon_punctatus
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