EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26068981	NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells.	Oncotarget	2015 Aug 28	Zhu Y	-
21689627	An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer.	Am J Pathol	2011 Aug	Karhemo PR	doi: 10.1016/j.ajpath.2011.04.009
28513872	Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.	J Cell Biochem	2017 Dec	Liu GY	doi: 10.1002/jcb.26135
19535344	The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.	Haematologica	2009 Jul	Bonvini P	doi: 10.3324/haematol.2008.004861
25907517	Nucleophosmin overexpression is associated with poor survival in astrocytoma.	APMIS	2015 Jun	Kuo YH	doi: 10.1111/apm.12381
15665273	Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.	Cancer Res	2005 Jan 1	Hayami R	-
20145123	Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.	Cancer Res	2010 Feb 15	Chang TP	doi: 10.1158/0008-5472.CAN-09-2453
16205118	Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein.	Cell Cycle	2005 Nov	den Besten W	-
19103589	Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing.	J Biol Chem	2009 Feb 20	Cullen SP	doi: 10.1074/jbc.M807913200
20424160	The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.	J Biol Chem	2010 Jun 25	Hegazy SA	doi: 10.1074/jbc.M110.121988
25818168	GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer.	J Cell Mol Med	2015 Jun	Kim JY	doi: 10.1111/jcmm.12474
26754533	The leukemic oncoprotein NPM1-RARA inhibits TP53 activity.	Leuk Lymphoma	2016 Aug	Swaney EM	doi: 10.3109/10428194.2015.1124992
27501253	Downregulation of nucleophosmin expression inhibited proliferation and induced apoptosis in salivary gland adenoid cystic carcinoma.	J Oral Pathol Med	2017 Mar	Li S	doi: 10.1111/jop.12482
22631075	Expression of nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells.	J Biomed Sci	2012 May 25	Liu Y	doi: 10.1186/1423-0127-19-53.
25805179	Pharmacologic inhibition of the CK2-mediated phosphorylation of B23/NPM in cancer cells selectively modulates genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis.	Mol Cell Biochem	2015 Jun	Perera Y	doi: 10.1007/s11010-015-2370-x
23831574	Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.	Oncogene	2014 May 29	Vascotto C	doi: 10.1038/onc.2013.251
15310764	Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.	J Biol Chem	2004 Oct 1	Li J	-
16857742	Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells.	Mol Pharmacol	2006 Oct	Yeh CW	-
17549383	PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells.	Int J Mol Med	2007 Jul	Jankun J	-
23489260	Clinical significance of nucleophosmin/B23 and human epidermal growth factor receptor 2/neu expressions in gastric cancers.	APMIS	2013 Jul	Zhou F	doi: 10.1111/apm.12043
21979956	Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells.	J Biol Chem	2011 Dec 2	Bhat UG	doi: 10.1074/jbc.M111.270843
15514966	Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.	Int J Cancer	2005 Mar 1	Lee HZ	-
24787960	Regulatory role of nucleophosmin during the differentiation of human liver cancer cells.	Int J Oncol	2014 Jul	Xu DH	doi: 10.3892/ijo.2014.2407
18298902	Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.	Acta Pharmacol Sin	2008 Mar	Tsui KH	doi: 10.1111/j.1745-7254.2008.00747.x.
19734942	RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells.	Oncogene	2009 Nov 26	Jian Y	doi: 10.1038/onc.2009.275
18037965	Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.	Oncogene	2008 May 1	L??otoing L	-
21182834	Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells.	Exp Cell Res	2011 Apr 15	Kim CK	doi: 10.1016/j.yexcr.2010.12.013
21258971	Nucleophosmin delocalization in thyroid tumour cells.	Endocr Pathol	2011 Mar	Pianta A	doi: 10.1007/s12022-011-9147-x.
23536448	Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence.	Int J Cancer	2013 Oct 1	Wong JC	doi: 10.1002/ijc.28180
21084279	BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.	Cancer Res	2011 Jan 1	Wang HF	doi: 10.1158/0008-5472.CAN-10-0030
28262969	Relocation of NPM Affects the Malignant Phenotypes of Hepatoma SMMC-7721 Cells.	J Cell Biochem	2017 Oct	Li X	doi: 10.1002/jcb.25971
29535419	DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.	Oncogene	2018 May	Tang J	doi: 10.1038/s41388-018-0196-1
29466670	Long noncoding RNA HOTAIR mediates the estrogen-induced metastasis of endometrial cancer cells via the miR-646/NPM1 axis.	Am J Physiol Cell Physiol	2018 Jun 1	Zhou YX	doi: 10.1152/ajpcell.00222.2017

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr5	171406416	Intron	novel		0.44
BLCA	chr5	171387948	5'UTR	novel		0.61
BLCA	chr5	171387913	5'UTR	rs200132495		0.2
BRCA	chr5	171400840	In_Frame_Del	novel	I196_T199del	0.07
BRCA	chr5	171400198	Silent	rs368568545	A190A	0.16
CESC	chr5	171406473	Intron	novel		0.4
CESC	chr5	171391347	Missense_Mutation	novel	E61K	0.09
CESC	chr5	171400181	Missense_Mutation	NA	E185K	0.37
CESC	chr5	171387909	5'UTR	rs780914482		0.19
CHOL	chr5	171387886	5'UTR	novel		0.51
COAD	chr5	171387940	5'UTR	rs750018655		0.3
COAD	chr5	171390073	Missense_Mutation	NA	K27N	0.31	Nucleoplasmin
COAD	chr5	171400842	Missense_Mutation	rs376742289	I196V	0.17
COAD	chr5	171387955	Missense_Mutation	novel	D3Y	0.46
COAD	chr5	171392957	Missense_Mutation	novel	D168G	0.08
COAD	chr5	171406399	Intron	rs202084580		0.29
COAD	chr5	171392966	Splice_Site	novel	X173_splice	0.35
COAD	chr5	171392931	Frame_Shift_Ins	novel	*A160Tfs3**	0.11
COAD	chr5	171392932	Missense_Mutation	novel	A160P	0.07
ESCA	chr5	171410812	3'UTR	rs1059683		0.43
ESCA	chr5	171390092	Missense_Mutation	novel	D34H	0.2	Nucleoplasmin
GBM	chr5	171410611	3'UTR	novel		0.45
GBM	chr5	171392765	Missense_Mutation	NA	L136F	0.34
GBM	chr5	171410603	3'UTR	novel		0.36
HNSC	chr5	171406479	Intron	novel		0.08
HNSC	chr5	171406478	Intron	novel		0.12
HNSC	chr5	171406480	Intron	novel		0.13
HNSC	chr5	171391329	Missense_Mutation	novel	D55N	0.42	Nucleoplasmin
KIRC	chr5	171405336	Nonsense_Mutation	novel	*K236Lfs2**	0.06
KIRC	chr5	171406470	Intron	novel		0.06
KIRC	chr5	171406472	Intron	novel		0.06
KIRP	chr5	171391324	Frame_Shift_Ins	novel	*D55Gfs2**	0.48	Nucleoplasmin
KIRP	chr5	171387853	5'UTR	rs543958094		0.35
KIRP	chr5	171387982	Missense_Mutation	novel	L12M	0.29
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.37
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.42
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.43
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.25
LAML	chr5	171410540	Frame_Shift_Ins	NA	*W288Cfs12**	0.24
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.27
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.44
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.28
LAML	chr5	171410540	Frame_Shift_Ins	NA	*W288Cfs12**	0.54
LAML	chr5	171407716	Missense_Mutation	rs765654691	K263R	0.39
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.43
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.44
LAML	chr5	171410539	Frame_Shift_Ins	rs758959453	*W288Cfs12**	0.35
LGG	chr5	171390086	Missense_Mutation	novel	K32E	0.4	Nucleoplasmin
LGG	chr5	171400845	Nonsense_Mutation	novel	R197*	0.2
LGG	chr5	171410637	3'UTR	novel		0.17
LIHC	chr5	171410530	Missense_Mutation	NA	I284V	0.38
LUAD	chr5	171387834	5'UTR	novel		0.15
LUAD	chr5	171406443	Intron	novel		0.19
LUAD	chr5	171410580	3'UTR	novel		0.17
LUAD	chr5	171400893	Missense_Mutation	novel	D213N	0.09
LUAD	chr5	171392769	Missense_Mutation	NA	I138V	0.23
LUAD	chr5	171387862	5'UTR	novel		0.31
LUAD	chr5	171407747	Missense_Mutation	NA	K273N	0.18
LUAD	chr5	171391323	Missense_Mutation	NA	A53S	0.45	Nucleoplasmin
LUAD	chr5	171392797	Missense_Mutation	NA	G147D	0.08
LUAD	chr5	171410571	3'UTR	novel		0.15
LUAD	chr5	171387860	5'UTR	novel		0.24
LUAD	chr5	171392783	Silent	NA	R142R	0.13
LUSC	chr5	171392925	Silent	rs535582867	K157K	0.57
OV	chr5	171387861	5'UTR	novel		0.5
PAAD	chr5	171410694	3'UTR	novel		0.09
READ	chr5	171400863	Missense_Mutation	novel	N203H	0.23
SKCM	chr5	171407769	Missense_Mutation	novel	Q281E	0.08
SKCM	chr5	171391764	Missense_Mutation	NA	S106L	0.7
SKCM	chr5	171407756	Silent	NA	F276F	0.28
SKCM	chr5	171410571	3'UTR	novel		0.13
SKCM	chr5	171400902	Missense_Mutation	NA	P216S	0.35
SKCM	chr5	171387855	5'UTR	novel		0.25
SKCM	chr5	171410604	3'UTR	rs756780247		0.62
SKCM	chr5	171387959	Missense_Mutation	novel	S4L	0.22
SKCM	chr5	171410610	3'UTR	novel		0.55
SKCM	chr5	171391383	Missense_Mutation	novel	K73Q	0.33
STAD	chr5	171400868	Silent	NA	A204A	0.22
STAD	chr5	171391789	Silent	NA	Q114Q	0.38
STAD	chr5	171391388	Silent	NA	V74V	0.07
STAD	chr5	171406399	Intron	rs202084580		0.3
UCEC	chr5	171410809	3'UTR	novel		0.18
UCEC	chr5	171410810	3'UTR	novel		0.18
UCEC	chr5	171405401	Missense_Mutation	NA	K257E	0.4
UCEC	chr5	171410583	3'UTR	novel		0.58
UCEC	chr5	171405349	Missense_Mutation	novel	K239N	0.08
UCEC	chr5	171400868	Silent	NA	A204A	0.41
UCEC	chr5	171405301	Splice_Site	novel	X224_splice	0.27
UCEC	chr5	171406459	Intron	novel		0.41
UCEC	chr5	171406398	Intron	NA		0.32
UCEC	chr5	171406543	Intron	novel		0.27
UCEC	chr5	171410595	3'UTR	rs768033269		0.23
UCEC	chr5	171391724	Missense_Mutation	novel	E93K	0.17
UCEC	chr5	171407724	Missense_Mutation	novel	A266T	0.21
UCEC	chr5	171405304	Splice_Region	novel	G224G	0.36
UCEC	chr5	171410770	3'UTR	novel		0.47
UCEC	chr5	171405313	Silent	novel	S227S	0.52
UCEC	chr5	171391743	Missense_Mutation	NA	V99A	0.28
UCEC	chr5	171392931	Silent	novel	A159A	0.29
UCEC	chr5	171410615	3'UTR	novel		0.11
UCS	chr5	171392810	Silent	novel	V151V	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.589	2.1944e-60
KIRP	AMP	0.1146	0.069756
KIRP	DEL	0.0347	0.11554
LGG	DEL	0.0955	1.86e-07
LUAD	AMP	0.1764	0.24967
LUSC	DEL	0.6108	0.002071
MESO	DEL	0.1264	0.20184
PRAD	AMP	0.0366	0.16448
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00047	Kaplan-Meier Survival Analysis
SARC	0.0072	Kaplan-Meier Survival Analysis
HNSC	0.00072	Kaplan-Meier Survival Analysis
ESCA	0.012	Kaplan-Meier Survival Analysis
KIRP	0.00064	Kaplan-Meier Survival Analysis
PAAD	0.0046	Kaplan-Meier Survival Analysis
BLCA	0.013	Kaplan-Meier Survival Analysis
LAML	0.0068	Kaplan-Meier Survival Analysis
KICH	0.02	Kaplan-Meier Survival Analysis
UCEC	0.023	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LGG	0.0073	Kaplan-Meier Survival Analysis
LUAD	0.013	Kaplan-Meier Survival Analysis
OV	0.042	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000181163 (Gene tree)
Gene ID: 4869
Gene Symbol: NPM1
Alias: B23|NPM
Full Name: nucleophosmin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 24,022 bases
Position: chr5:171,387,116-171,411,137
Accession: 7910
RBP type: canonical RBP
Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000377408	Nucleoplasmin	PF03066.15	4.1e-42	1	1
ENSP00000341168	Nucleoplasmin	PF03066.15	4.4e-42	1	1
ENSP00000296930	Nucleoplasmin	PF03066.15	5.4e-42	1	1
ENSP00000428755	Nucleoplasmin	PF03066.15	5.4e-42	1	1
ENSP00000429485	Nucleoplasmin	PF03066.15	9.7e-21	1	1
ENSP00000428647	Nucleoplasmin	PF03066.15	1.1e-10	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12000845	Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins.	Nucleic Acids Res	2002 May 15	Yang C	-
19188445	APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.	Mol Cell Biol	2009 Apr	Vascotto C	doi: 10.1128/MCB.01337-08
24106084	Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association.	Nucleic Acids Res	2014 Jan	Hisaoka M	doi: 10.1093/nar/gkt897
26624888	Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.	PLoS One	2015 Dec 1	Nouri K	doi: 10.1371/journal.pone.0143634
7527039	The nucleic acid binding activity of nucleolar protein B23.1 resides in its carboxyl-terminal end.	J Biol Chem	1994 Dec 9	Wang D	-
9880328	Association of nonribosomal nucleolar proteins in ribonucleoprotein complexes during interphase and mitosis.	Mol Biol Cell	1999 Jan	Pinol-Roma S	-
12058066	The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.	Mol Biol Cell	2002 Jun	Okuwaki M	-
16376875	Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing.	FEBS Lett	2006 Jan 23	Tarapore P	-
16894202	Proteome alterations in human host cells infected with coxsackievirus B3.	J Gen Virol	2006 Sep	Rassmann A	-
16740634	Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression.	J Biol Chem	2006 Aug 4	Dhar SK	-
16690610	Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs.	J Biol Chem	2006 Jul 14	Zou T	-
17426024	The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene.	J Biol Chem	2007 Jun 1	Xu Y	-
22362753	Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.	Nucleic Acids Res	2012 Jun	Okuwaki M	doi: 10.1093/nar/gks162
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
20713446	Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.	Mol Cell Biol	2010 Oct	Hisaoka M	doi: 10.1128/MCB.00299-10
20404347	Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity.	J Biol Chem	2010 Jun 18	Wang G	doi: 10.1074/jbc.M110.100396
29507312	Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography.	Sci Rep	2018 Mar 5	Sakashita G	doi: 10.1038/s41598-018-22359-w.
9211969	Experimental induction of prenucleolar bodies (PNBs) in interphase cells: interphase PNBs show similar characteristics as those typically observed at telophase of mitosis in untreated cells.	Chromosoma	1997 Jun	Zatsepina OV	-
9154111	Structural and functional relationships of toyocamycin on NPM-translocation.	Anticancer Drug Des	1997 Apr	Finch RA	-
11900641	Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells.	Cloning	2001	Hyttel P	-
11309377	The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication.	J Biol Chem	2001 Jul 6	Huang WH	-
20699270	Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.	Nucleic Acids Res	2010 Dec	Fantini D	doi: 10.1093/nar/gkq691
29589547	Implication of B23/NPM1 in Viral Infections, Potential Uses of B23/NPM1 Inhibitors as Antiviral Therapy.	Infect Disord Drug Targets	2019	Lobaina Y	doi: 10.2174/1871526518666180327124412.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000521260	NPM1-207	510	-	-	- (aa)	-	-
ENST00000517671	NPM1-204	1338	-	ENSP00000428755	294 (aa)	-	P06748
ENST00000519955	NPM1-206	571	-	-	- (aa)	-	-
ENST00000521672	NPM1-208	597	-	ENSP00000429485	111 (aa)	-	E5RI98
ENST00000296930	NPM1-201	1758	-	ENSP00000296930	294 (aa)	-	P06748
ENST00000351986	NPM1-202	1237	-	ENSP00000341168	265 (aa)	-	P06748
ENST00000523622	NPM1-211	247	-	ENSP00000428647	59 (aa)	-	E5RGW4
ENST00000393820	NPM1-203	1598	-	ENSP00000377408	259 (aa)	-	P06748
ENST00000523339	NPM1-210	268	-	-	- (aa)	-	-
ENST00000524204	NPM1-212	640	-	-	- (aa)	-	-
ENST00000518587	NPM1-205	670	-	-	- (aa)	-	-
ENST00000521710	NPM1-209	386	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000181163's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000181163	Erythrocyte Indices	8.3100000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181163's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000181163	NPM1	51	45.614	ENSG00000107833	NPM3	62	44.545
ENSG00000181163	NPM1	68	30.055	ENSG00000158806	NPM2	76	39.423

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181163	NPM1	94	71.841	ENSAMEG00000015951	-	100	72.202	Ailuropoda_melanoleuca
ENSG00000181163	NPM1	100	74.627	ENSAMEG00000015473	-	99	62.455	Ailuropoda_melanoleuca
ENSG00000181163	NPM1	100	96.949	ENSAMEG00000003910	-	100	96.949	Ailuropoda_melanoleuca
ENSG00000181163	NPM1	97	77.193	ENSAMEG00000007124	-	96	76.207	Ailuropoda_melanoleuca
ENSG00000181163	NPM1	99	93.814	ENSANAG00000037659	-	95	93.814	Aotus_nancymaae
ENSG00000181163	NPM1	99	88.316	ENSANAG00000026461	-	95	87.973	Aotus_nancymaae
ENSG00000181163	NPM1	99	85.171	ENSANAG00000022354	-	95	85.171	Aotus_nancymaae
ENSG00000181163	NPM1	99	72.165	ENSANAG00000037965	-	83	70.790	Aotus_nancymaae
ENSG00000181163	NPM1	100	88.060	ENSANAG00000034949	-	100	81.081	Aotus_nancymaae
ENSG00000181163	NPM1	100	80.597	ENSANAG00000019097	-	100	74.903	Aotus_nancymaae
ENSG00000181163	NPM1	100	86.567	ENSANAG00000033497	-	95	82.772	Aotus_nancymaae
ENSG00000181163	NPM1	100	78.378	ENSANAG00000030360	-	100	77.656	Aotus_nancymaae
ENSG00000181163	NPM1	100	86.567	ENSBTAG00000015316	-	90	87.891	Bos_taurus
ENSG00000181163	NPM1	100	92.517	ENSBTAG00000016347	NPM1	100	90.816	Bos_taurus
ENSG00000181163	NPM1	93	80.833	ENSBTAG00000003838	-	95	80.417	Bos_taurus
ENSG00000181163	NPM1	100	85.283	ENSBTAG00000035379	-	100	84.151	Bos_taurus
ENSG00000181163	NPM1	100	97.635	ENSCJAG00000019334	-	100	97.635	Callithrix_jacchus
ENSG00000181163	NPM1	99	96.923	ENSCJAG00000046641	-	97	92.857	Callithrix_jacchus
ENSG00000181163	NPM1	100	88.435	ENSCJAG00000046561	-	100	88.776	Callithrix_jacchus
ENSG00000181163	NPM1	99	90.698	ENSCJAG00000016467	-	92	88.372	Callithrix_jacchus
ENSG00000181163	NPM1	99	93.411	ENSCJAG00000046459	-	99	91.450	Callithrix_jacchus
ENSG00000181163	NPM1	100	62.687	ENSCAFG00000032713	-	99	68.163	Canis_familiaris
ENSG00000181163	NPM1	100	97.966	ENSCAFG00000016912	NPM1	100	97.966	Canis_familiaris
ENSG00000181163	NPM1	100	83.582	ENSCAFG00000031513	-	99	92.617	Canis_familiaris
ENSG00000181163	NPM1	100	86.567	ENSCAFG00000005880	-	100	85.374	Canis_familiaris
ENSG00000181163	NPM1	100	81.973	ENSCAFG00000004550	-	100	81.293	Canis_familiaris
ENSG00000181163	NPM1	100	94.237	ENSCAFG00000007173	-	100	93.559	Canis_familiaris
ENSG00000181163	NPM1	100	96.396	ENSCAFG00020023812	-	99	95.185	Canis_lupus_dingo
ENSG00000181163	NPM1	99	96.525	ENSCAFG00020022999	-	99	95.926	Canis_lupus_dingo
ENSG00000181163	NPM1	100	88.060	ENSCAFG00020008713	-	100	85.324	Canis_lupus_dingo
ENSG00000181163	NPM1	99	91.321	ENSCAFG00020022491	-	99	90.217	Canis_lupus_dingo
ENSG00000181163	NPM1	100	90.189	ENSCHIG00000013986	-	100	89.434	Capra_hircus
ENSG00000181163	NPM1	100	79.104	ENSCHIG00000008417	-	99	74.721	Capra_hircus
ENSG00000181163	NPM1	100	91.525	ENSCHIG00000012256	-	100	91.186	Capra_hircus
ENSG00000181163	NPM1	100	80.597	ENSCHIG00000012856	-	100	73.129	Capra_hircus
ENSG00000181163	NPM1	100	97.368	ENSTSYG00000014739	-	100	97.368	Carlito_syrichta
ENSG00000181163	NPM1	100	92.177	ENSTSYG00000028503	-	100	92.177	Carlito_syrichta
ENSG00000181163	NPM1	86	91.667	ENSTSYG00000033989	-	100	73.962	Carlito_syrichta
ENSG00000181163	NPM1	100	90.385	ENSTSYG00000036865	-	99	88.806	Carlito_syrichta
ENSG00000181163	NPM1	100	88.060	ENSTSYG00000028279	-	100	79.932	Carlito_syrichta
ENSG00000181163	NPM1	100	83.582	ENSTSYG00000031172	-	97	80.612	Carlito_syrichta
ENSG00000181163	NPM1	100	85.075	ENSTSYG00000031261	-	100	81.973	Carlito_syrichta
ENSG00000181163	NPM1	100	85.075	ENSTSYG00000029274	-	98	83.955	Carlito_syrichta
ENSG00000181163	NPM1	100	82.090	ENSTSYG00000036574	-	100	91.919	Carlito_syrichta
ENSG00000181163	NPM1	100	90.816	ENSCCAG00000031772	-	100	90.476	Cebus_capucinus
ENSG00000181163	NPM1	100	96.139	ENSCCAG00000016051	-	100	96.139	Cebus_capucinus
ENSG00000181163	NPM1	86	86.458	ENSCCAG00000035992	-	100	84.348	Cebus_capucinus
ENSG00000181163	NPM1	99	89.734	ENSCCAG00000030721	-	98	88.115	Cebus_capucinus
ENSG00000181163	NPM1	100	86.792	ENSCCAG00000026527	-	100	86.792	Cebus_capucinus
ENSG00000181163	NPM1	99	92.123	ENSCCAG00000036007	-	95	91.781	Cebus_capucinus
ENSG00000181163	NPM1	100	89.456	ENSCCAG00000020726	-	100	90.476	Cebus_capucinus
ENSG00000181163	NPM1	99	93.411	ENSCCAG00000028933	-	100	91.197	Cebus_capucinus
ENSG00000181163	NPM1	99	95.533	ENSCCAG00000028063	-	95	95.533	Cebus_capucinus
ENSG00000181163	NPM1	100	97.619	ENSCCAG00000034814	-	100	97.619	Cebus_capucinus
ENSG00000181163	NPM1	100	86.885	ENSCCAG00000025336	-	100	71.080	Cebus_capucinus
ENSG00000181163	NPM1	98	80.303	ENSCCAG00000028221	-	98	65.748	Cebus_capucinus
ENSG00000181163	NPM1	100	77.860	ENSCATG00000014743	-	93	78.598	Cercocebus_atys
ENSG00000181163	NPM1	100	79.104	ENSCATG00000042295	-	99	75.439	Cercocebus_atys
ENSG00000181163	NPM1	100	91.156	ENSCATG00000042248	-	100	89.796	Cercocebus_atys
ENSG00000181163	NPM1	100	99.660	ENSCATG00000013107	NPM1	100	99.660	Cercocebus_atys
ENSG00000181163	NPM1	94	89.423	ENSCATG00000041646	-	99	78.355	Cercocebus_atys
ENSG00000181163	NPM1	99	81.229	ENSCATG00000040754	-	99	75.600	Cercocebus_atys
ENSG00000181163	NPM1	100	79.104	ENSCATG00000042881	-	99	82.018	Cercocebus_atys
ENSG00000181163	NPM1	100	79.104	ENSCATG00000036822	-	99	73.387	Cercocebus_atys
ENSG00000181163	NPM1	100	84.170	ENSCATG00000038882	-	98	82.667	Cercocebus_atys
ENSG00000181163	NPM1	90	94.000	ENSCATG00000040801	-	100	83.665	Cercocebus_atys
ENSG00000181163	NPM1	93	81.387	ENSCLAG00000014392	-	100	82.482	Chinchilla_lanigera
ENSG00000181163	NPM1	100	80.597	ENSCLAG00000003117	-	100	73.585	Chinchilla_lanigera
ENSG00000181163	NPM1	100	82.090	ENSCLAG00000012694	-	96	80.144	Chinchilla_lanigera
ENSG00000181163	NPM1	96	92.958	ENSCLAG00000009385	-	100	92.606	Chinchilla_lanigera
ENSG00000181163	NPM1	100	76.119	ENSCLAG00000004609	-	99	76.408	Chinchilla_lanigera
ENSG00000181163	NPM1	99	76.744	ENSCSAG00000014589	-	99	69.492	Chlorocebus_sabaeus
ENSG00000181163	NPM1	98	77.431	ENSCSAG00000017017	-	99	75.347	Chlorocebus_sabaeus
ENSG00000181163	NPM1	100	81.973	ENSCSAG00000010293	-	100	82.288	Chlorocebus_sabaeus
ENSG00000181163	NPM1	98	81.890	ENSCSAG00000006996	-	100	80.212	Chlorocebus_sabaeus
ENSG00000181163	NPM1	100	99.660	ENSCSAG00000009697	NPM1	100	99.660	Chlorocebus_sabaeus
ENSG00000181163	NPM1	100	77.612	ENSCANG00000043584	-	94	76.426	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	100	85.075	ENSCANG00000000036	-	94	79.498	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	78	70.435	ENSCANG00000033869	-	100	70.435	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	86	93.750	ENSCANG00000040963	-	100	83.085	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	99	86.254	ENSCANG00000036541	-	100	84.586	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	99	84.880	ENSCANG00000032930	-	100	82.653	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	99	91.473	ENSCANG00000034649	-	96	91.045	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	99	82.818	ENSCANG00000041706	-	100	75.510	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	100	98.980	ENSCANG00000015582	NPM1	100	98.980	Colobus_angolensis_palliatus
ENSG00000181163	NPM1	85	87.234	ENSCGRG00001008438	-	100	81.739	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	77.273	ENSCGRG00001013263	-	100	78.030	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	98	79.134	ENSCGRG00001009246	-	100	75.862	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	73.134	ENSCGRG00001000174	-	92	62.245	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	91.935	ENSCGRG00001016397	-	100	93.814	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	83.582	ENSCGRG00001022274	-	90	83.260	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	95.849	ENSCGRG00001001985	-	100	95.849	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	89.057	ENSCGRG00001011827	-	100	89.811	Cricetulus_griseus_chok1gshd
ENSG00000181163	NPM1	100	73.134	ENSCGRG00000003411	-	92	62.245	Cricetulus_griseus_crigri
ENSG00000181163	NPM1	100	83.333	ENSCGRG00000005050	-	100	79.779	Cricetulus_griseus_crigri
ENSG00000181163	NPM1	95	92.857	ENSCGRG00000009086	-	100	95.510	Cricetulus_griseus_crigri
ENSG00000181163	NPM1	98	79.134	ENSCGRG00000016922	-	100	75.862	Cricetulus_griseus_crigri
ENSG00000181163	NPM1	100	78.846	ENSCGRG00000005392	-	100	79.615	Cricetulus_griseus_crigri
ENSG00000181163	NPM1	100	86.441	ENSCGRG00000002856	-	100	81.887	Cricetulus_griseus_crigri
ENSG00000181163	NPM1	100	80.597	ENSDNOG00000046080	-	83	89.916	Dasypus_novemcinctus
ENSG00000181163	NPM1	95	75.899	ENSDNOG00000046334	-	100	76.259	Dasypus_novemcinctus
ENSG00000181163	NPM1	97	67.200	ENSDNOG00000033175	-	95	68.400	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	70.149	ENSDNOG00000046742	-	100	57.627	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	69.565	ENSDNOG00000041943	-	100	69.463	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	69.728	ENSDNOG00000042206	-	91	69.048	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	76.119	ENSDNOG00000049249	-	94	73.665	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	71.642	ENSDNOG00000033324	-	82	81.513	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	75.385	ENSDNOG00000019697	-	100	65.763	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	92.177	ENSDNOG00000036168	-	100	93.878	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	85.075	ENSDNOG00000034360	-	82	92.437	Dasypus_novemcinctus
ENSG00000181163	NPM1	86	70.690	ENSDNOG00000039191	-	82	72.603	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	70.149	ENSDNOG00000039437	-	99	62.016	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	94.898	ENSDNOG00000045917	-	100	94.898	Dasypus_novemcinctus
ENSG00000181163	NPM1	70	66.667	ENSDNOG00000034640	-	100	60.920	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	68.657	ENSDNOG00000040609	-	100	77.333	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	93.694	ENSDNOG00000003012	-	98	79.322	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	80.597	ENSDNOG00000038864	-	100	78.988	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	91.837	ENSDNOG00000042329	-	100	93.537	Dasypus_novemcinctus
ENSG00000181163	NPM1	100	88.136	ENSDORG00000029351	-	100	82.313	Dipodomys_ordii
ENSG00000181163	NPM1	94	95.273	ENSDORG00000028337	-	100	95.273	Dipodomys_ordii
ENSG00000181163	NPM1	86	97.895	ENSDORG00000025877	-	97	80.093	Dipodomys_ordii
ENSG00000181163	NPM1	100	96.429	ENSEASG00005017409	-	100	95.833	Equus_asinus_asinus
ENSG00000181163	NPM1	100	88.060	ENSEASG00005011903	-	100	86.415	Equus_asinus_asinus
ENSG00000181163	NPM1	85	95.745	ENSECAG00000018581	-	100	88.696	Equus_caballus
ENSG00000181163	NPM1	100	78.788	ENSECAG00000033495	-	90	83.772	Equus_caballus
ENSG00000181163	NPM1	100	98.305	ENSECAG00000021950	NPM1	61	98.305	Equus_caballus
ENSG00000181163	NPM1	100	98.496	ENSFCAG00000030268	-	100	98.496	Felis_catus
ENSG00000181163	NPM1	100	83.333	ENSFDAG00000014567	-	100	82.653	Fukomys_damarensis
ENSG00000181163	NPM1	100	69.492	ENSFDAG00000010240	-	99	66.239	Fukomys_damarensis
ENSG00000181163	NPM1	86	85.417	ENSFDAG00000012861	-	99	77.686	Fukomys_damarensis
ENSG00000181163	NPM1	100	90.816	ENSFDAG00000008410	-	100	90.816	Fukomys_damarensis
ENSG00000181163	NPM1	99	87.629	ENSGGOG00000036702	-	95	88.316	Gorilla_gorilla
ENSG00000181163	NPM1	100	97.297	ENSGGOG00000027925	-	92	97.595	Gorilla_gorilla
ENSG00000181163	NPM1	100	83.582	ENSGGOG00000028098	-	99	80.786	Gorilla_gorilla
ENSG00000181163	NPM1	100	89.831	ENSGGOG00000023746	-	100	82.578	Gorilla_gorilla
ENSG00000181163	NPM1	98	82.642	ENSGGOG00000039900	-	100	82.642	Gorilla_gorilla
ENSG00000181163	NPM1	100	76.779	ENSGGOG00000021992	-	100	76.779	Gorilla_gorilla
ENSG00000181163	NPM1	100	83.582	ENSGGOG00000022556	-	87	81.852	Gorilla_gorilla
ENSG00000181163	NPM1	100	100.000	ENSGGOG00000007220	NPM1	100	100.000	Gorilla_gorilla
ENSG00000181163	NPM1	85	86.170	ENSHGLG00000005844	-	100	82.609	Heterocephalus_glaber_female
ENSG00000181163	NPM1	99	83.268	ENSHGLG00000013163	-	94	83.658	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	75.564	ENSHGLG00000006794	-	100	75.564	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	85.075	ENSHGLG00000000889	-	100	81.683	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	76.531	ENSHGLG00000000491	-	100	75.850	Heterocephalus_glaber_female
ENSG00000181163	NPM1	98	87.823	ENSHGLG00000002635	-	100	86.296	Heterocephalus_glaber_female
ENSG00000181163	NPM1	93	82.540	ENSHGLG00000001374	-	100	68.966	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	96.525	ENSHGLG00000013669	-	100	96.838	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	83.582	ENSHGLG00000004806	-	100	79.245	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	83.446	ENSHGLG00000010827	-	84	83.108	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	90.169	ENSHGLG00000001408	-	100	90.169	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	81.818	ENSHGLG00000004335	-	100	81.132	Heterocephalus_glaber_female
ENSG00000181163	NPM1	100	81.818	ENSHGLG00100009347	-	100	81.132	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	79.710	ENSHGLG00100001990	-	100	70.946	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	85.393	ENSHGLG00100015287	-	100	85.393	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	90.816	ENSHGLG00100013382	-	100	90.816	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	83.398	ENSHGLG00100009508	-	100	83.784	Heterocephalus_glaber_male
ENSG00000181163	NPM1	93	82.540	ENSHGLG00100011191	-	100	67.241	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	88.136	ENSHGLG00100017081	-	100	74.717	Heterocephalus_glaber_male
ENSG00000181163	NPM1	99	82.171	ENSHGLG00100007816	-	99	82.900	Heterocephalus_glaber_male
ENSG00000181163	NPM1	97	81.481	ENSHGLG00100015786	-	92	75.849	Heterocephalus_glaber_male
ENSG00000181163	NPM1	86	87.500	ENSHGLG00100005717	-	100	81.905	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	80.597	ENSHGLG00100007560	-	99	71.852	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	85.374	ENSHGLG00100017339	-	100	85.714	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	88.060	ENSHGLG00100018644	-	91	86.957	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	82.550	ENSHGLG00100014367	-	100	82.653	Heterocephalus_glaber_male
ENSG00000181163	NPM1	100	88.060	ENSSTOG00000014732	-	100	84.068	Ictidomys_tridecemlineatus
ENSG00000181163	NPM1	100	85.034	ENSSTOG00000033121	-	100	84.014	Ictidomys_tridecemlineatus
ENSG00000181163	NPM1	100	82.090	ENSSTOG00000029788	-	99	76.957	Ictidomys_tridecemlineatus
ENSG00000181163	NPM1	100	88.136	ENSSTOG00000027949	-	100	83.333	Ictidomys_tridecemlineatus
ENSG00000181163	NPM1	100	81.081	ENSJJAG00000012395	-	100	81.081	Jaculus_jaculus
ENSG00000181163	NPM1	100	70.149	ENSJJAG00000024130	-	100	74.340	Jaculus_jaculus
ENSG00000181163	NPM1	100	96.241	ENSJJAG00000014455	-	100	96.241	Jaculus_jaculus
ENSG00000181163	NPM1	100	88.462	ENSJJAG00000015333	-	100	90.000	Jaculus_jaculus
ENSG00000181163	NPM1	100	85.714	ENSJJAG00000021702	-	100	86.486	Jaculus_jaculus
ENSG00000181163	NPM1	100	88.095	ENSJJAG00000018938	-	100	87.415	Jaculus_jaculus
ENSG00000181163	NPM1	100	79.104	ENSJJAG00000015777	-	95	72.266	Jaculus_jaculus
ENSG00000181163	NPM1	96	55.319	ENSLAFG00000030894	-	94	54.255	Loxodonta_africana
ENSG00000181163	NPM1	100	94.237	ENSLAFG00000007677	-	100	93.898	Loxodonta_africana
ENSG00000181163	NPM1	100	85.075	ENSLAFG00000030988	-	100	73.810	Loxodonta_africana
ENSG00000181163	NPM1	100	77.612	ENSMFAG00000031214	-	92	87.943	Macaca_fascicularis
ENSG00000181163	NPM1	100	97.297	ENSMFAG00000044195	-	96	97.388	Macaca_fascicularis
ENSG00000181163	NPM1	100	99.099	ENSMFAG00000043579	-	100	92.830	Macaca_fascicularis
ENSG00000181163	NPM1	86	89.474	ENSMFAG00000040340	-	100	75.094	Macaca_fascicularis
ENSG00000181163	NPM1	87	80.412	ENSMFAG00000040524	-	100	78.696	Macaca_fascicularis
ENSG00000181163	NPM1	100	97.297	ENSMFAG00000000888	-	99	94.565	Macaca_fascicularis
ENSG00000181163	NPM1	100	82.090	ENSMFAG00000038984	-	94	79.038	Macaca_fascicularis
ENSG00000181163	NPM1	100	82.993	ENSMFAG00000044243	-	100	81.973	Macaca_fascicularis
ENSG00000181163	NPM1	100	98.198	ENSMFAG00000002674	-	99	97.770	Macaca_fascicularis
ENSG00000181163	NPM1	78	93.103	ENSMMUG00000006239	-	100	80.100	Macaca_mulatta
ENSG00000181163	NPM1	100	99.099	ENSMMUG00000015781	-	100	96.959	Macaca_mulatta
ENSG00000181163	NPM1	100	96.139	ENSMMUG00000023352	-	99	95.539	Macaca_mulatta
ENSG00000181163	NPM1	95	84.906	ENSMMUG00000012517	-	100	79.245	Macaca_mulatta
ENSG00000181163	NPM1	98	71.280	ENSMMUG00000006631	-	100	70.588	Macaca_mulatta
ENSG00000181163	NPM1	95	87.736	ENSMMUG00000031047	-	94	78.351	Macaca_mulatta
ENSG00000181163	NPM1	100	77.612	ENSMMUG00000008038	-	92	87.943	Macaca_mulatta
ENSG00000181163	NPM1	100	77.966	ENSMMUG00000006020	-	100	76.604	Macaca_mulatta
ENSG00000181163	NPM1	100	97.297	ENSMMUG00000017463	-	99	96.283	Macaca_mulatta
ENSG00000181163	NPM1	100	98.198	ENSMMUG00000005139	-	95	97.683	Macaca_mulatta
ENSG00000181163	NPM1	86	93.684	ENSMMUG00000013373	-	94	74.459	Macaca_mulatta
ENSG00000181163	NPM1	100	79.104	ENSMNEG00000035640	-	99	75.107	Macaca_nemestrina
ENSG00000181163	NPM1	100	97.297	ENSMNEG00000019062	-	96	97.761	Macaca_nemestrina
ENSG00000181163	NPM1	100	77.612	ENSMNEG00000034784	-	92	88.652	Macaca_nemestrina
ENSG00000181163	NPM1	86	89.474	ENSMNEG00000030427	-	100	73.413	Macaca_nemestrina
ENSG00000181163	NPM1	86	92.632	ENSMNEG00000041823	-	100	73.208	Macaca_nemestrina
ENSG00000181163	NPM1	100	86.567	ENSMNEG00000032152	-	97	82.824	Macaca_nemestrina
ENSG00000181163	NPM1	100	99.320	ENSMNEG00000039074	-	100	99.320	Macaca_nemestrina
ENSG00000181163	NPM1	87	81.443	ENSMNEG00000030459	-	100	78.696	Macaca_nemestrina
ENSG00000181163	NPM1	100	80.597	ENSMNEG00000017421	-	100	77.778	Macaca_nemestrina
ENSG00000181163	NPM1	86	92.708	ENSMLEG00000033178	-	96	80.603	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	99.660	ENSMLEG00000030928	-	100	99.660	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	79.104	ENSMLEG00000025668	-	100	78.927	Mandrillus_leucophaeus
ENSG00000181163	NPM1	86	92.632	ENSMLEG00000041646	-	100	74.219	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	80.743	ENSMLEG00000035224	-	100	80.068	Mandrillus_leucophaeus
ENSG00000181163	NPM1	99	82.818	ENSMLEG00000038707	-	87	80.669	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	80.597	ENSMLEG00000036869	-	99	83.406	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	77.612	ENSMLEG00000043971	-	92	88.652	Mandrillus_leucophaeus
ENSG00000181163	NPM1	98	84.375	ENSMLEG00000034288	-	100	83.333	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	79.104	ENSMLEG00000039578	-	100	71.429	Mandrillus_leucophaeus
ENSG00000181163	NPM1	100	83.582	ENSMAUG00000001039	-	99	72.109	Mesocricetus_auratus
ENSG00000181163	NPM1	100	69.057	ENSMAUG00000021018	-	86	91.304	Mesocricetus_auratus
ENSG00000181163	NPM1	100	85.075	ENSMAUG00000015943	-	94	77.606	Mesocricetus_auratus
ENSG00000181163	NPM1	100	83.051	ENSMAUG00000007102	-	97	69.549	Mesocricetus_auratus
ENSG00000181163	NPM1	100	93.585	ENSMAUG00000009288	-	100	93.208	Mesocricetus_auratus
ENSG00000181163	NPM1	100	72.581	ENSMAUG00000005696	-	100	68.675	Mesocricetus_auratus
ENSG00000181163	NPM1	100	97.297	ENSMICG00000049412	-	100	93.258	Microcebus_murinus
ENSG00000181163	NPM1	100	98.127	ENSMICG00000002717	-	100	98.127	Microcebus_murinus
ENSG00000181163	NPM1	100	69.728	ENSMICG00000030363	-	100	69.388	Microcebus_murinus
ENSG00000181163	NPM1	99	79.401	ENSMOCG00000022384	-	97	81.273	Microtus_ochrogaster
ENSG00000181163	NPM1	99	88.281	ENSMOCG00000005366	-	97	89.199	Microtus_ochrogaster
ENSG00000181163	NPM1	100	83.582	ENSMOCG00000001628	-	99	90.000	Microtus_ochrogaster
ENSG00000181163	NPM1	98	75.290	ENSMOCG00000019450	-	100	73.359	Microtus_ochrogaster
ENSG00000181163	NPM1	100	94.717	ENSMOCG00000001485	-	100	95.094	Microtus_ochrogaster
ENSG00000181163	NPM1	100	80.597	ENSMODG00000014244	-	100	76.316	Monodelphis_domestica
ENSG00000181163	NPM1	100	83.582	ENSMODG00000006503	-	99	84.397	Monodelphis_domestica
ENSG00000181163	NPM1	100	93.585	MGP_CAROLIEiJ_G0016192	Npm1	100	93.962	Mus_caroli
ENSG00000181163	NPM1	100	93.585	ENSMUSG00000057113	Npm1	100	93.962	Mus_musculus
ENSG00000181163	NPM1	100	88.060	MGP_PahariEiJ_G0017328	Npm1	100	84.746	Mus_pahari
ENSG00000181163	NPM1	100	92.857	MGP_SPRETEiJ_G0017033	Npm1	100	93.878	Mus_spretus
ENSG00000181163	NPM1	100	85.075	MGP_SPRETEiJ_G0032922	-	97	84.549	Mus_spretus
ENSG00000181163	NPM1	99	92.620	ENSMPUG00000012858	-	94	91.304	Mustela_putorius_furo
ENSG00000181163	NPM1	100	83.582	ENSMLUG00000027963	-	100	63.899	Myotis_lucifugus
ENSG00000181163	NPM1	75	77.376	ENSMLUG00000022332	-	100	75.566	Myotis_lucifugus
ENSG00000181163	NPM1	100	68.254	ENSMLUG00000030379	-	100	48.000	Myotis_lucifugus
ENSG00000181163	NPM1	80	60.345	ENSMLUG00000025018	-	90	54.658	Myotis_lucifugus
ENSG00000181163	NPM1	100	71.747	ENSMLUG00000023462	-	100	69.888	Myotis_lucifugus
ENSG00000181163	NPM1	100	90.847	ENSMLUG00000005693	-	100	90.847	Myotis_lucifugus
ENSG00000181163	NPM1	98	71.212	ENSMLUG00000022847	-	100	66.327	Myotis_lucifugus
ENSG00000181163	NPM1	100	96.604	ENSNGAG00000016679	-	100	96.604	Nannospalax_galili
ENSG00000181163	NPM1	100	80.597	ENSNGAG00000000048	-	100	79.623	Nannospalax_galili
ENSG00000181163	NPM1	100	85.075	ENSNGAG00000016711	-	96	79.514	Nannospalax_galili
ENSG00000181163	NPM1	92	75.806	ENSNGAG00000020094	-	98	69.550	Nannospalax_galili
ENSG00000181163	NPM1	100	76.119	ENSNGAG00000011454	-	100	72.453	Nannospalax_galili
ENSG00000181163	NPM1	100	99.660	ENSNLEG00000000304	NPM1	100	99.660	Nomascus_leucogenys
ENSG00000181163	NPM1	99	89.535	ENSNLEG00000033932	-	99	86.331	Nomascus_leucogenys
ENSG00000181163	NPM1	99	81.164	ENSNLEG00000016500	-	99	80.000	Nomascus_leucogenys
ENSG00000181163	NPM1	100	75.676	ENSNLEG00000033081	-	100	75.676	Nomascus_leucogenys
ENSG00000181163	NPM1	99	83.774	ENSNLEG00000035618	-	87	83.774	Nomascus_leucogenys
ENSG00000181163	NPM1	100	82.090	ENSNLEG00000009293	-	100	78.491	Nomascus_leucogenys
ENSG00000181163	NPM1	100	88.136	ENSNLEG00000030364	-	100	72.481	Nomascus_leucogenys
ENSG00000181163	NPM1	93	82.909	ENSOPRG00000007381	NPM1	100	84.364	Ochotona_princeps
ENSG00000181163	NPM1	100	77.966	ENSODEG00000015414	-	100	70.189	Octodon_degus
ENSG00000181163	NPM1	100	77.612	ENSODEG00000006228	-	81	72.075	Octodon_degus
ENSG00000181163	NPM1	86	93.750	ENSODEG00000010569	-	100	86.266	Octodon_degus
ENSG00000181163	NPM1	100	90.136	ENSODEG00000018973	-	100	90.136	Octodon_degus
ENSG00000181163	NPM1	100	86.567	ENSODEG00000013745	-	100	83.456	Octodon_degus
ENSG00000181163	NPM1	100	96.610	ENSODEG00000020133	-	100	96.610	Octodon_degus
ENSG00000181163	NPM1	100	90.182	ENSODEG00000002235	-	100	90.182	Octodon_degus
ENSG00000181163	NPM1	99	91.120	ENSODEG00000000160	-	100	83.729	Octodon_degus
ENSG00000181163	NPM1	100	95.623	ENSODEG00000020044	-	100	95.623	Octodon_degus
ENSG00000181163	NPM1	93	90.074	ENSODEG00000019619	-	100	90.074	Octodon_degus
ENSG00000181163	NPM1	100	77.612	ENSODEG00000001923	-	100	62.264	Octodon_degus
ENSG00000181163	NPM1	95	79.286	ENSOANG00000007792	NPM1	100	78.571	Ornithorhynchus_anatinus
ENSG00000181163	NPM1	98	71.212	ENSOCUG00000026013	-	98	57.621	Oryctolagus_cuniculus
ENSG00000181163	NPM1	100	86.567	ENSOCUG00000026815	-	100	75.850	Oryctolagus_cuniculus
ENSG00000181163	NPM1	100	89.116	ENSOCUG00000011117	-	100	89.116	Oryctolagus_cuniculus
ENSG00000181163	NPM1	100	82.090	ENSOCUG00000026704	-	100	72.449	Oryctolagus_cuniculus
ENSG00000181163	NPM1	97	73.846	ENSOCUG00000023636	-	99	53.409	Oryctolagus_cuniculus
ENSG00000181163	NPM1	100	88.060	ENSOCUG00000026724	-	100	79.252	Oryctolagus_cuniculus
ENSG00000181163	NPM1	100	88.060	ENSOCUG00000021499	NPM1	100	80.272	Oryctolagus_cuniculus
ENSG00000181163	NPM1	98	64.032	ENSOGAG00000031837	-	99	61.034	Otolemur_garnettii
ENSG00000181163	NPM1	100	96.284	ENSOGAG00000013616	-	100	96.284	Otolemur_garnettii
ENSG00000181163	NPM1	100	80.597	ENSOGAG00000027543	-	100	76.654	Otolemur_garnettii
ENSG00000181163	NPM1	100	83.774	ENSOGAG00000030243	-	100	83.396	Otolemur_garnettii
ENSG00000181163	NPM1	100	85.075	ENSOGAG00000029283	-	100	85.085	Otolemur_garnettii
ENSG00000181163	NPM1	98	61.905	ENSOGAG00000024990	-	97	61.168	Otolemur_garnettii
ENSG00000181163	NPM1	99	62.452	ENSOGAG00000031663	-	99	63.043	Otolemur_garnettii
ENSG00000181163	NPM1	84	73.118	ENSOGAG00000025437	-	97	63.801	Otolemur_garnettii
ENSG00000181163	NPM1	100	70.787	ENSOGAG00000031508	-	100	69.663	Otolemur_garnettii
ENSG00000181163	NPM1	100	94.218	ENSOARG00000005458	-	96	93.197	Ovis_aries
ENSG00000181163	NPM1	100	92.881	ENSOARG00000002826	-	96	92.881	Ovis_aries
ENSG00000181163	NPM1	100	95.608	ENSOARG00000021035	-	96	95.608	Ovis_aries
ENSG00000181163	NPM1	99	90.816	ENSOARG00000003553	-	100	91.156	Ovis_aries
ENSG00000181163	NPM1	100	95.608	ENSOARG00000017399	-	96	95.608	Ovis_aries
ENSG00000181163	NPM1	100	94.595	ENSOARG00000004133	-	96	94.595	Ovis_aries
ENSG00000181163	NPM1	100	91.156	ENSPPAG00000042574	-	100	91.156	Pan_paniscus
ENSG00000181163	NPM1	100	83.582	ENSPPAG00000039851	-	100	81.509	Pan_paniscus
ENSG00000181163	NPM1	100	100.000	ENSPPAG00000041884	NPM1	100	99.660	Pan_paniscus
ENSG00000181163	NPM1	99	78.007	ENSPPAG00000028836	-	94	76.632	Pan_paniscus
ENSG00000181163	NPM1	99	87.500	ENSPPAG00000027951	-	87	87.121	Pan_paniscus
ENSG00000181163	NPM1	100	83.582	ENSPPAG00000036646	-	97	80.952	Pan_paniscus
ENSG00000181163	NPM1	100	79.661	ENSPPAG00000043776	-	100	74.340	Pan_paniscus
ENSG00000181163	NPM1	100	86.038	ENSPPAG00000028711	-	100	84.906	Pan_paniscus
ENSG00000181163	NPM1	100	89.831	ENSPPAG00000043065	-	100	80.488	Pan_paniscus
ENSG00000181163	NPM1	100	82.156	ENSPPAG00000040610	-	100	81.784	Pan_paniscus
ENSG00000181163	NPM1	100	68.726	ENSPPRG00000017753	-	99	69.112	Panthera_pardus
ENSG00000181163	NPM1	100	98.496	ENSPPRG00000014990	-	100	98.496	Panthera_pardus
ENSG00000181163	NPM1	100	98.496	ENSPTIG00000021568	-	100	98.496	Panthera_tigris_altaica
ENSG00000181163	NPM1	99	87.879	ENSPTRG00000052422	-	87	87.121	Pan_troglodytes
ENSG00000181163	NPM1	100	87.925	ENSPTRG00000052386	-	100	86.792	Pan_troglodytes
ENSG00000181163	NPM1	99	97.595	ENSPTRG00000046378	-	92	97.595	Pan_troglodytes
ENSG00000181163	NPM1	100	82.156	ENSPTRG00000052368	-	100	81.784	Pan_troglodytes
ENSG00000181163	NPM1	100	100.000	ENSPTRG00000049153	NPM1	100	100.000	Pan_troglodytes
ENSG00000181163	NPM1	100	76.981	ENSPTRG00000044889	-	100	75.472	Pan_troglodytes
ENSG00000181163	NPM1	100	91.525	ENSPTRG00000047416	-	100	82.927	Pan_troglodytes
ENSG00000181163	NPM1	100	100.000	ENSPTRG00000034281	-	99	97.482	Pan_troglodytes
ENSG00000181163	NPM1	99	87.285	ENSPTRG00000042970	-	95	86.942	Pan_troglodytes
ENSG00000181163	NPM1	100	83.582	ENSPTRG00000051964	-	100	76.604	Pan_troglodytes
ENSG00000181163	NPM1	100	79.104	ENSPANG00000001071	-	99	80.519	Papio_anubis
ENSG00000181163	NPM1	100	98.198	ENSPANG00000007591	-	99	97.026	Papio_anubis
ENSG00000181163	NPM1	86	93.750	ENSPANG00000025445	-	99	78.008	Papio_anubis
ENSG00000181163	NPM1	100	99.660	ENSPANG00000000217	-	100	99.660	Papio_anubis
ENSG00000181163	NPM1	99	89.347	ENSPANG00000004185	-	85	86.090	Papio_anubis
ENSG00000181163	NPM1	99	87.984	ENSPANG00000004075	-	98	84.982	Papio_anubis
ENSG00000181163	NPM1	100	80.597	ENSPANG00000030894	-	99	73.790	Papio_anubis
ENSG00000181163	NPM1	85	94.681	ENSPANG00000016748	-	84	79.725	Papio_anubis
ENSG00000181163	NPM1	100	80.597	ENSPANG00000000607	-	100	78.571	Papio_anubis
ENSG00000181163	NPM1	87	82.474	ENSPANG00000030483	-	100	79.130	Papio_anubis
ENSG00000181163	NPM1	99	87.984	ENSPANG00000019628	-	88	86.260	Papio_anubis
ENSG00000181163	NPM1	100	85.075	ENSPANG00000009192	-	100	80.612	Papio_anubis
ENSG00000181163	NPM1	100	76.119	ENSPANG00000033083	-	92	87.943	Papio_anubis
ENSG00000181163	NPM1	100	82.090	ENSPEMG00000009245	-	99	81.028	Peromyscus_maniculatus_bairdii
ENSG00000181163	NPM1	100	92.664	ENSPEMG00000008328	-	100	94.208	Peromyscus_maniculatus_bairdii
ENSG00000181163	NPM1	100	94.717	ENSPEMG00000010032	-	100	95.094	Peromyscus_maniculatus_bairdii
ENSG00000181163	NPM1	100	80.597	ENSPEMG00000020195	-	95	73.585	Peromyscus_maniculatus_bairdii
ENSG00000181163	NPM1	100	89.831	ENSPEMG00000019831	-	100	88.776	Peromyscus_maniculatus_bairdii
ENSG00000181163	NPM1	100	85.374	ENSPCIG00000013615	-	100	85.374	Phascolarctos_cinereus
ENSG00000181163	NPM1	100	72.881	ENSPCIG00000029043	-	96	73.978	Phascolarctos_cinereus
ENSG00000181163	NPM1	100	82.090	ENSPCIG00000013017	-	99	89.404	Phascolarctos_cinereus
ENSG00000181163	NPM1	100	69.697	ENSPPYG00000018802	-	94	54.579	Pongo_abelii
ENSG00000181163	NPM1	99	79.038	ENSPPYG00000018154	-	100	78.007	Pongo_abelii
ENSG00000181163	NPM1	98	67.692	ENSPPYG00000020292	-	100	60.618	Pongo_abelii
ENSG00000181163	NPM1	85	93.617	ENSPPYG00000018620	-	100	89.565	Pongo_abelii
ENSG00000181163	NPM1	100	77.612	ENSPPYG00000017919	-	86	86.555	Pongo_abelii
ENSG00000181163	NPM1	100	99.099	ENSPPYG00000016037	NPM1	100	99.635	Pongo_abelii
ENSG00000181163	NPM1	100	80.597	ENSPPYG00000013098	-	100	74.060	Pongo_abelii
ENSG00000181163	NPM1	100	88.060	ENSPCAG00000006555	-	100	82.373	Procavia_capensis
ENSG00000181163	NPM1	100	92.105	ENSPCOG00000016188	-	100	91.353	Propithecus_coquereli
ENSG00000181163	NPM1	100	82.090	ENSPCOG00000023601	-	94	82.657	Propithecus_coquereli
ENSG00000181163	NPM1	100	92.881	ENSPCOG00000024038	-	100	93.609	Propithecus_coquereli
ENSG00000181163	NPM1	100	96.271	ENSPVAG00000002211	-	100	96.271	Pteropus_vampyrus
ENSG00000181163	NPM1	100	80.597	ENSRNOG00000039997	AABR07055527.1	100	71.429	Rattus_norvegicus
ENSG00000181163	NPM1	100	93.197	ENSRNOG00000004616	Npm1	100	93.537	Rattus_norvegicus
ENSG00000181163	NPM1	100	83.582	ENSRNOG00000018923	AABR07041089.1	100	75.510	Rattus_norvegicus
ENSG00000181163	NPM1	98	70.588	ENSRNOG00000060714	AABR07007744.2	78	64.780	Rattus_norvegicus
ENSG00000181163	NPM1	100	78.571	ENSRBIG00000043933	-	84	78.231	Rhinopithecus_bieti
ENSG00000181163	NPM1	100	77.612	ENSRBIG00000027474	-	92	72.199	Rhinopithecus_bieti
ENSG00000181163	NPM1	100	99.660	ENSRBIG00000042550	NPM1	100	99.660	Rhinopithecus_bieti
ENSG00000181163	NPM1	100	77.778	ENSRBIG00000031889	-	100	77.778	Rhinopithecus_bieti
ENSG00000181163	NPM1	99	89.003	ENSRBIG00000039572	-	100	84.906	Rhinopithecus_bieti
ENSG00000181163	NPM1	86	89.583	ENSRBIG00000023618	-	97	74.330	Rhinopithecus_bieti
ENSG00000181163	NPM1	99	92.248	ENSRBIG00000031681	-	98	88.448	Rhinopithecus_bieti
ENSG00000181163	NPM1	99	98.973	ENSRROG00000041536	-	99	97.778	Rhinopithecus_roxellana
ENSG00000181163	NPM1	100	99.660	ENSRROG00000045149	NPM1	100	99.660	Rhinopithecus_roxellana
ENSG00000181163	NPM1	100	79.252	ENSRROG00000034095	-	97	91.892	Rhinopithecus_roxellana
ENSG00000181163	NPM1	97	92.857	ENSRROG00000028901	-	100	92.366	Rhinopithecus_roxellana
ENSG00000181163	NPM1	98	82.609	ENSRROG00000045758	-	100	78.231	Rhinopithecus_roxellana
ENSG00000181163	NPM1	100	88.060	ENSRROG00000035590	-	99	79.221	Rhinopithecus_roxellana
ENSG00000181163	NPM1	99	92.784	ENSRROG00000039724	-	99	91.473	Rhinopithecus_roxellana
ENSG00000181163	NPM1	99	82.818	ENSRROG00000029111	-	94	82.288	Rhinopithecus_roxellana
ENSG00000181163	NPM1	99	90.034	ENSRROG00000028538	-	95	89.347	Rhinopithecus_roxellana
ENSG00000181163	NPM1	100	88.060	ENSRROG00000030596	-	99	85.034	Rhinopithecus_roxellana
ENSG00000181163	NPM1	99	94.845	ENSSBOG00000032831	-	99	93.309	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	100	89.189	ENSSBOG00000025734	-	100	89.189	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	100	97.959	ENSSBOG00000033634	-	100	97.959	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	99	94.845	ENSSBOG00000036028	-	95	94.502	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	100	83.582	ENSSBOG00000036188	-	100	76.604	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	96	77.108	ENSSBOG00000023352	-	99	76.923	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	99	80.069	ENSSBOG00000022295	-	95	80.069	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	100	88.136	ENSSBOG00000026679	-	100	75.862	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	100	91.497	ENSSBOG00000007092	-	100	91.156	Saimiri_boliviensis_boliviensis
ENSG00000181163	NPM1	93	78.838	ENSSHAG00000009312	-	99	72.059	Sarcophilus_harrisii
ENSG00000181163	NPM1	98	57.588	ENSSHAG00000008062	-	98	57.198	Sarcophilus_harrisii
ENSG00000181163	NPM1	100	62.687	ENSSSCG00000004427	-	93	56.015	Sus_scrofa
ENSG00000181163	NPM1	84	78.495	ENSSSCG00000038891	-	94	67.111	Sus_scrofa
ENSG00000181163	NPM1	86	72.449	ENSSSCG00000040078	-	100	56.746	Sus_scrofa
ENSG00000181163	NPM1	83	58.296	ENSSSCG00000034550	-	100	58.296	Sus_scrofa
ENSG00000181163	NPM1	100	98.305	ENSSSCG00000016998	-	100	98.305	Sus_scrofa
ENSG00000181163	NPM1	100	90.169	ENSTTRG00000008370	-	100	90.508	Tursiops_truncatus
ENSG00000181163	NPM1	100	88.060	ENSUAMG00000023574	-	100	86.735	Ursus_americanus
ENSG00000181163	NPM1	100	97.288	ENSUMAG00000024653	-	100	97.288	Ursus_maritimus
ENSG00000181163	NPM1	100	82.090	ENSVPAG00000002450	-	100	78.571	Vicugna_pacos
ENSG00000181163	NPM1	100	83.582	ENSVVUG00000015801	-	100	83.271	Vulpes_vulpes
ENSG00000181163	NPM1	100	97.288	ENSVVUG00000002639	-	100	97.288	Vulpes_vulpes
ENSG00000181163	NPM1	100	90.816	ENSVVUG00000017786	-	100	90.816	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000055	ribosomal large subunit export from nucleus	21873635.	IBA	Process
GO:0000056	ribosomal small subunit export from nucleus	21873635.	IBA	Process
GO:0001047	core promoter binding	19160485.	IDA	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	15087454.19160485.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	12058066.	IDA	Function
GO:0004860	protein kinase inhibitor activity	12882984.	IDA	Function
GO:0005515	protein binding	12080348.12882984.15144954.15161933.15184379.15989956.16376884.16648475.16957780.17015463.17318229.17438371.17475909.17602943.18259216.18420587.19160485.19188445.19410545.20075868.20159986.20618440.21326211.21822216.22510990.22528486.22712502.22720776.23019224.23892143.24462683.24857377.25416956.25956029.26496610.29568061.30021884.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	12080348.22720776.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	12058066.19160485.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	11420665.12080348.16041368.17475909.18809582.19160485.19188445.19208757.22528486.25956029.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9121481.	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	11051553.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006281	DNA repair	19188445.	IDA	Process
GO:0006334	nucleosome assembly	11602260.	IDA	Process
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0006407	rRNA export from nucleus	21873635.	IBA	Process
GO:0006886	intracellular protein transport	12080348.	TAS	Process
GO:0006913	nucleocytoplasmic transport	16041368.	IDA	Process
GO:0006913	nucleocytoplasmic transport	12080348.	TAS	Process
GO:0007098	centrosome cycle	11051553.	IMP	Process
GO:0007165	signal transduction	16130169.	NAS	Process
GO:0007569	cell aging	12080348.	IMP	Process
GO:0008104	protein localization	18420587.	IDA	Process
GO:0008134	transcription factor binding	25956029.	IPI	Function
GO:0008284	positive regulation of cell proliferation	22528486.	IDA	Process
GO:0008285	negative regulation of cell proliferation	12080348.	IMP	Process
GO:0010824	regulation of centrosome duplication	21873635.	IBA	Process
GO:0010826	negative regulation of centrosome duplication	16041368.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0019901	protein kinase binding	20352051.	IPI	Function
GO:0030957	Tat protein binding	9094689.	IDA	Function
GO:0031616	spindle pole centrosome	16041368.	IDA	Component
GO:0032071	regulation of endodeoxyribonuclease activity	19188445.	IDA	Process
GO:0032991	protein-containing complex	19160485.	IDA	Component
GO:0032993	protein-DNA complex	19160485.	IDA	Component
GO:0033613	activating transcription factor binding	19160485.	IPI	Function
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0034644	cellular response to UV	19160485.	IDA	Process
GO:0042255	ribosome assembly	12080348.	TAS	Process
GO:0042273	ribosomal large subunit biogenesis	21873635.	IBA	Process
GO:0042274	ribosomal small subunit biogenesis	21873635.	IBA	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042393	histone binding	11602260.	IDA	Function
GO:0042803	protein homodimerization activity	9121481.	IDA	Function
GO:0043023	ribosomal large subunit binding	18809582.	IDA	Function
GO:0043024	ribosomal small subunit binding	18809582.	IDA	Function
GO:0043066	negative regulation of apoptotic process	12882984.	IDA	Process
GO:0043066	negative regulation of apoptotic process	16130169.	NAS	Process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	12882984.	IDA	Process
GO:0045727	positive regulation of translation	12882984.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	22528486.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	19160485.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	25956029.	IMP	Process
GO:0046599	regulation of centriole replication	20352051.	IMP	Process
GO:0046982	protein heterodimerization activity	12080348.	IMP	Function
GO:0051059	NF-kappaB binding	15087454.	IDA	Function
GO:0051082	unfolded protein binding	10211837.	IDA	Function
GO:0051092	positive regulation of NF-kappaB transcription factor activity	15087454.	IMP	Process
GO:0051259	protein complex oligomerization	18809582.	IDA	Process
GO:0060699	regulation of endoribonuclease activity	19188445.	IDA	Process
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	12882984.	IDA	Process
GO:1902629	regulation of mRNA stability involved in cellular response to UV	12080348.	IMP	Process
GO:1902751	positive regulation of cell cycle G2/M phase transition	22528486.	IDA	Process
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	18809582.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.