EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18264133p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.Oncogene2008 Jun 19Kawase Tdoi: 10.1038/onc.2008.32

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1588626502Missense_MutationNAA98V0.28
BLCAchr1588629378SilentnovelR231R0.46
BLCAchr1588630216Missense_MutationNAM300I0.38
BLCAchr1588630088Missense_MutationnovelD258H0.28
BLCAchr1588626702Missense_MutationnovelR165W0.16RNase_T
BRCAchr1588626645Missense_MutationnovelY146H0.11RNase_T
BRCAchr1588630266Missense_MutationnovelA317V0.13
BRCAchr1588626562Missense_MutationNAV118A0.35RNase_T
CESCchr1588629359Missense_MutationnovelG225D0.54
CESCchr15886309803'UTRnovel0.38
CESCchr1588626313Missense_Mutationrs139013526R35L0.26
COADchr15886303183'UTRnovel0.16
COADchr1588626423Missense_MutationnovelT72A0.31
COADchr1588626677SilentNAY156Y0.56
COADchr15886303043'UTRrs7812001310.41
COADchr1588629288Silentrs138959764A201A0.13
COADchr1588630070Missense_MutationNAG252R0.18
COADchr15886303163'UTRrs7562134970.41
ESCAchr1588626337Missense_MutationnovelR43L0.43
ESCAchr15886309453'UTRnovel0.57
GBMchr1588626552Missense_MutationnovelC115G0.21RNase_T
HNSCchr1588630116Missense_Mutationrs201760461R267Q0.14
HNSCchr1588626338SilentnovelR43R0.83
HNSCchr1588626413Silentrs780933013F68F0.32
LUADchr15886261915'UTRnovel0.31
LUADchr1588626747Missense_MutationnovelE180Q0.22
LUADchr1588626461SilentNAL84L0.17
LUADchr1588630077Nonsense_MutationnovelS254*0.38
LUADchr1588626504Missense_MutationNAP99S0.57
LUSCchr1588626601Missense_MutationnovelR131L0.1RNase_T
LUSCchr1588630162Missense_MutationnovelW282C0.64
LUSCchr1588629396SilentNAL237L0.08
LUSCchr1588629267SilentnovelA194A0.15
OVchr1588629287Missense_Mutationrs368922473A201V0.38
PAADchr1588626652Missense_MutationnovelR148K0.15RNase_T
PRADchr1588629397Missense_MutationnovelA238T0.11
SKCMchr1588629345SilentnovelF220F0.35
SKCMchr1588626258Missense_Mutationrs749170954L17F0.45
SKCMchr1588626769Intronnovel0.18
SKCMchr1588629300SilentNAV205V0.1
SKCMchr1588626650Silentrs35195058I147I0.46
STADchr1588629372SilentnovelR229R0.07
STADchr1588626324Missense_Mutationrs756247681R39W0.3
STADchr1588626371SilentNAS54S0.34
STADchr1588630059Missense_MutationNAV248A0.28
STADchr1588629320Missense_Mutationrs561034272R212Q0.35
STADchr15886262005'UTRnovel0.2
STADchr1588629267Silentrs758372060A194A0.19
UCECchr1588626458Missense_MutationnovelC83W0.42
UCECchr1588626678Missense_Mutationrs148606540R157C0.29RNase_T
UCECchr1588629397Missense_MutationnovelA238T0.32
UCECchr1588626568Missense_Mutationrs766037818T120M0.36RNase_T
UCECchr15886310593'UTRnovel0.22
UCECchr1588629246SilentNAG187G0.42
UCECchr15886304293'UTRnovel0.25
UCECchr1588626657Missense_MutationnovelE150K0.28RNase_T
UCECchr1588626626SilentnovelG139G0.17
UCECchr15886261915'UTRnovel0.36
UCECchr1588626788Intronnovel0.28
UCECchr15886310943'UTRnovel0.62
UCECchr1588630062Missense_Mutationrs766404986G249D0.45
UCECchr1588629319Missense_Mutationrs763210791R212W0.3
UCECchr1588629277Missense_Mutationrs756014603D198N0.14
UCECchr1588629330SilentnovelT215T0.13
UCECchr15886302983'UTRnovel0.3
UCECchr1588626324Missense_Mutationrs756247681R39W0.25
UCECchr1588630257Missense_MutationnovelR314K0.25
UCECchr1588630108Missense_MutationNAE264D0.43
UCECchr1588630165SilentnovelT283T0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.21690.0058042
LGGAMP0.02140.19963
LIHCDEL0.17030.056724
PAADAMP0.07610.20695
PAADDEL0.10330.13216
SKCMAMP0.24529.6912e-06

Survival Analysis
CancerP-value Q-value
THYM0.043

Kaplan-Meier Survival Analysis

KIRC0.016

Kaplan-Meier Survival Analysis

MESO0.014

Kaplan-Meier Survival Analysis

SKCM0.0015

Kaplan-Meier Survival Analysis

UCEC0.0063

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000181026 (Gene tree)
Gene ID
64782
Gene Symbol
AEN
Alias
FLJ12484|FLJ12562|ISG20L1
Full Name
apoptosis enhancing nuclease
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
27,602 bases
Position
chr15:88,604,681-88,632,282
Accession
25722
RBP type
canonical RBP
Summary
(Apoptosis Enhancing Nuclease) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ISG20L2.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000331944RNase_TPF00929.246.7e-1611
ENSP00000453631RNase_TPF00929.249.1e-0811
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000559528AEN-205895-ENSP00000453631179 (aa)-H0YMJ6
ENST00000557927AEN-2035039--- (aa)--
ENST00000560174AEN-206461--- (aa)--
ENST00000332810AEN-2013117XM_005254966ENSP00000331944325 (aa)XP_005255023Q8WTP8
ENST00000558327AEN-204883--- (aa)--
ENST00000557787AEN-2021242--- (aa)--
Gene Model
Click here to download ENSG00000181026's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000181026Alzheimer Disease2.4138175E-00517998437
ENSG00000181026Sleep9E-627126917
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000181026rs80240581588621800ANight sleep phenotypes27126917[0.12-0.3] unit increase0.2095EFO_0005271
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181026's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000181026AEN5561.453ENSG00000143319ISG20L25161.453
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000181026AEN9980.745ENSAMEG00000012798AEN10080.745Ailuropoda_melanoleuca
ENSG00000181026AEN10093.538ENSANAG00000026698AEN10093.538Aotus_nancymaae
ENSG00000181026AEN10080.615ENSBTAG00000017632AEN9980.615Bos_taurus
ENSG00000181026AEN10092.308ENSCJAG00000012988AEN10092.308Callithrix_jacchus
ENSG00000181026AEN10082.769ENSCAFG00000011521AEN10082.769Canis_familiaris
ENSG00000181026AEN10082.462ENSCAFG00020018839AEN10082.462Canis_lupus_dingo
ENSG00000181026AEN10079.077ENSCHIG00000001561AEN9979.077Capra_hircus
ENSG00000181026AEN9986.420ENSTSYG00000012416AEN9986.420Carlito_syrichta
ENSG00000181026AEN6868.468ENSCAPG00000006550-10068.468Cavia_aperea
ENSG00000181026AEN9978.154ENSCPOG00000021693AEN9978.154Cavia_porcellus
ENSG00000181026AEN10091.385ENSCCAG00000037160AEN10091.385Cebus_capucinus
ENSG00000181026AEN10094.462ENSCATG00000034567AEN10094.462Cercocebus_atys
ENSG00000181026AEN10076.667ENSCLAG00000008791AEN9978.638Chinchilla_lanigera
ENSG00000181026AEN10094.462ENSCSAG00000017196AEN10094.462Chlorocebus_sabaeus
ENSG00000181026AEN8851.488ENSCPBG00000017884AEN8550.148Chrysemys_picta_bellii
ENSG00000181026AEN10092.923ENSCANG00000037330AEN10092.923Colobus_angolensis_palliatus
ENSG00000181026AEN9975.077ENSCGRG00001021559Aen9975.077Cricetulus_griseus_chok1gshd
ENSG00000181026AEN10074.847ENSCGRG00000000641Aen9975.077Cricetulus_griseus_crigri
ENSG00000181026AEN10079.330ENSDNOG00000001849-10083.548Dasypus_novemcinctus
ENSG00000181026AEN9966.111ENSDORG00000015546Aen9969.231Dipodomys_ordii
ENSG00000181026AEN9369.935ENSETEG00000006167AEN10072.876Echinops_telfairi
ENSG00000181026AEN10081.846ENSEASG00005015361AEN10081.846Equus_asinus_asinus
ENSG00000181026AEN10081.846ENSECAG00000037942AEN10081.846Equus_caballus
ENSG00000181026AEN10063.128ENSEEUG00000007015AEN10068.647Erinaceus_europaeus
ENSG00000181026AEN9981.115ENSFCAG00000023571AEN9981.115Felis_catus
ENSG00000181026AEN8853.503ENSFALG00000010440AEN8452.548Ficedula_albicollis
ENSG00000181026AEN10077.301ENSFDAG00000009743AEN10076.994Fukomys_damarensis
ENSG00000181026AEN8850.000ENSGAGG00000013545AEN8549.706Gopherus_agassizii
ENSG00000181026AEN10099.441ENSGGOG00000010180AEN10099.385Gorilla_gorilla
ENSG00000181026AEN6665.728ENSHGLG00000008738-9965.728Heterocephalus_glaber_female
ENSG00000181026AEN10076.380ENSHGLG00100013826AEN10075.767Heterocephalus_glaber_male
ENSG00000181026AEN6870.136ENSSTOG00000011560-9870.136Ictidomys_tridecemlineatus
ENSG00000181026AEN6966.071ENSJJAG00000022647-9966.071Jaculus_jaculus
ENSG00000181026AEN10078.212ENSLAFG00000015182AEN10081.046Loxodonta_africana
ENSG00000181026AEN10094.769ENSMFAG00000001458AEN10094.769Macaca_fascicularis
ENSG00000181026AEN10094.769ENSMMUG00000022516AEN10094.769Macaca_mulatta
ENSG00000181026AEN10095.077ENSMNEG00000040133AEN10095.077Macaca_nemestrina
ENSG00000181026AEN10094.769ENSMLEG00000032850AEN10094.769Mandrillus_leucophaeus
ENSG00000181026AEN9976.000ENSMAUG00000000489Aen9976.000Mesocricetus_auratus
ENSG00000181026AEN10085.276ENSMICG00000027602AEN10085.276Microcebus_murinus
ENSG00000181026AEN9975.078ENSMOCG00000011735Aen9675.701Microtus_ochrogaster
ENSG00000181026AEN9762.539ENSMODG00000019584-9661.300Monodelphis_domestica
ENSG00000181026AEN9774.684MGP_CAROLIEiJ_G0029872Aen10069.565Mus_caroli
ENSG00000181026AEN9972.615ENSMUSG00000030609Aen10069.565Mus_musculus
ENSG00000181026AEN10073.313MGP_PahariEiJ_G0013094Aen9673.313Mus_pahari
ENSG00000181026AEN8173.762MGP_SPRETEiJ_G0030974-9576.684Mus_spretus
ENSG00000181026AEN10080.308ENSMPUG00000015821AEN8680.308Mustela_putorius_furo
ENSG00000181026AEN7683.806ENSMLUG00000023065AEN9984.082Myotis_lucifugus
ENSG00000181026AEN9778.616ENSNGAG00000011590Aen9878.616Nannospalax_galili
ENSG00000181026AEN10097.846ENSNLEG00000032314AEN10097.846Nomascus_leucogenys
ENSG00000181026AEN10054.839ENSMEUG00000005303-10060.000Notamacropus_eugenii
ENSG00000181026AEN6370.588ENSODEG00000015278-9570.588Octodon_degus
ENSG00000181026AEN9985.139ENSOGAG00000029852AEN9684.211Otolemur_garnettii
ENSG00000181026AEN10077.846ENSOARG00000010957AEN10077.846Ovis_aries
ENSG00000181026AEN10099.385ENSPPAG00000039598AEN10099.385Pan_paniscus
ENSG00000181026AEN9979.817ENSPPRG00000022756AEN9979.817Panthera_pardus
ENSG00000181026AEN10076.536ENSPTIG00000018966AEN7281.124Panthera_tigris_altaica
ENSG00000181026AEN10099.385ENSPTRG00000007422AEN10099.385Pan_troglodytes
ENSG00000181026AEN10095.077ENSPANG00000005905AEN10095.077Papio_anubis
ENSG00000181026AEN8856.314ENSPSIG00000014281AEN9355.290Pelodiscus_sinensis
ENSG00000181026AEN10075.229ENSPEMG00000020445Aen10075.229Peromyscus_maniculatus_bairdii
ENSG00000181026AEN9760.436ENSPCIG00000006401-9059.875Phascolarctos_cinereus
ENSG00000181026AEN10097.538ENSPPYG00000006755AEN10097.538Pongo_abelii
ENSG00000181026AEN10075.419ENSPCAG00000015481AEN9761.716Procavia_capensis
ENSG00000181026AEN10087.385ENSPCOG00000020924AEN10087.385Propithecus_coquereli
ENSG00000181026AEN10078.212ENSPVAG00000007189AEN9384.158Pteropus_vampyrus
ENSG00000181026AEN10074.847ENSRNOG00000018421Aen9674.847Rattus_norvegicus
ENSG00000181026AEN10092.923ENSRBIG00000031540AEN10092.923Rhinopithecus_bieti
ENSG00000181026AEN10093.538ENSRROG00000043282AEN10093.538Rhinopithecus_roxellana
ENSG00000181026AEN10090.769ENSSBOG00000021857AEN10090.769Saimiri_boliviensis_boliviensis
ENSG00000181026AEN9659.688ENSSHAG00000017070-9659.375Sarcophilus_harrisii
ENSG00000181026AEN10083.692ENSSSCG00000005102AEN10083.692Sus_scrofa
ENSG00000181026AEN8855.446ENSTGUG00000008335AEN9854.027Taeniopygia_guttata
ENSG00000181026AEN10078.212ENSTBEG00000016234AEN9880.189Tupaia_belangeri
ENSG00000181026AEN10076.536ENSTTRG00000014668AEN9281.126Tursiops_truncatus
ENSG00000181026AEN5488.571ENSUAMG00000019063-10088.571Ursus_americanus
ENSG00000181026AEN10083.077ENSVVUG00000012020AEN10083.077Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003676nucleic acid binding-IEAFunction
GO:0004527exonuclease activity16171785.18264133.IDAFunction
GO:0005515protein binding25416956.IPIFunction
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm16171785.18264133.IDAComponent
GO:0005730nucleolus18264133.IDAComponent
GO:0010212response to ionizing radiation16171785.IDAProcess
GO:0031965nuclear membrane-IDAComponent
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator18264133.IDAProcess
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEAProcess
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