EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28460446The cell polarity protein Scrib functions as a tumor suppressor in liver cancer.Oncotarget2017 Apr 18Kapil Sdoi: 10.18632/oncotarget.15713.
23730214CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells.Neoplasia2013 JunMetodieva G-
27562784Expression of cell polarity protein scribble differently affects prognosis in primary tumor and lymph node metastasis of breast cancer patients.Breast Cancer2017 MaySakakibara Jdoi: 10.1007/s12282-016-0715-2
21549346Aberrant overexpression of the cell polarity module scribble in human cancer.Am J Pathol2011 JunVaira Vdoi: 10.1016/j.ajpath.2011.02.028
15806148Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.Oncogene2005 Jun 23Navarro C-
20622900The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction.Oncogene2010 Sep 23Nagasaka Kdoi: 10.1038/onc.2010.265
15261375[hScrib: a potential novel tumor suppressor].Pathol Biol (Paris)2004 JulBorg JP-
16344308The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin.J Cell Biol2005 Dec 19Qin Y-
27380321ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.Nat Chem Biol2016 SepChen Bdoi: 10.1038/nchembio.2119
29152770Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness.Hepatology2018 MayWan Sdoi: 10.1002/hep.29669
21086040No association of polymorphisms in the cell polarity gene SCRIB with breast cancer risk in German population.Breast Cancer Res Treat2011 FebZhang Cdoi: 10.1007/s10549-010-1253-9
27428426Decreased Usage of Specific Scrib Exons Defines a More Malignant Phenotype of Breast Cancer With Worsened Survival.EBioMedicine2016 JunMetodieva Gdoi: 10.1016/j.ebiom.2016.05.009
20939435hScrib, a human homolog of Drosophila neoplastic tumor suppressor, is involved in the progress of endometrial cancer.Oncol Res2010Ouyang Z-
20936341No association of polymorphisms in the cell polarity gene SCRIB with breast cancer risk.Breast Cancer Res Treat2011 MayD??nnebier Tdoi: 10.1007/s10549-010-1194-3
21965329SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.J Clin Invest2011 NovPearson HBdoi: 10.1172/JCI58509
19041750Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.Cell2008 Nov 28Zhan Ldoi: 10.1016/j.cell.2008.09.045.
16619250Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.Int J Cancer2006 Sep 15Gardiol D-
22179838A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.Oncogene2012 Aug 9Anastas JNdoi: 10.1038/onc.2011.528
29144123The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1.Biochemistry2018 Jan 9Sundell GNdoi: 10.1021/acs.biochem.7b00965

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr8143810767SilentnovelP441P0.42
BLCAchr8143810789Missense_Mutationrs779811140S434L0.12
BLCAchr8143813340Missense_MutationNAD180N0.13
BLCAchr8143813523Silentrs773591724L150L0.66
BLCAchr8143812859SilentNAL249L0.13
BLCAchr8143793944Missense_MutationnovelG1289R0.13
BLCAchr8143812913Missense_MutationnovelR231G0.35
BLCAchr8143815326Missense_MutationnovelS16L0.25
BLCAchr8143813349Missense_MutationnovelE177Q0.2
BLCAchr8143804776Missense_MutationNAL934Q0.21
BLCAchr8143807563Missense_MutationnovelE723Q0.29
BLCAchr8143812886Missense_MutationnovelG240R0.16
BLCAchr8143812977IntronNA0.35
BLCAchr8143809568Missense_Mutationrs775403235E561K0.27
BLCAchr8143815217Silentrs751405745P52P0.42
BLCAchr8143812307Missense_MutationnovelE289K0.18
BLCAchr8143792808SilentnovelK1359K0.85
BLCAchr8143810529Missense_MutationnovelE494K0.23
BLCAchr8143813883SilentnovelI97I0.48
BLCAchr8143804791Missense_MutationnovelD929G0.25
BLCAchr8143807569Missense_Mutationrs782621145R721C0.28
BLCAchr8143810544Missense_Mutationrs137872634E489K0.3
BLCAchr8143807578Missense_MutationNAE718Q0.09
BLCAchr8143803532Missense_Mutationrs782093618R1152C0.38
BLCAchr8143809701Silentrs538041646A516A0.22
BLCAchr8143813523Silentrs773591724L150L0.11
BLCAchr8143815243Missense_MutationnovelD44H0.24
BRCAchr8143814111Frame_Shift_DelNAF56Sfs*40.18
BRCAchr8143803765Missense_Mutationrs781995997R1099Q0.38
BRCAchr8143795305Missense_MutationnovelH1248P0.64
BRCAchr8143808685Frame_Shift_DelnovelN680Tfs*370.09
BRCAchr8143808737Missense_MutationNAE663Q0.38
BRCAchr8143810740Silentrs748875240F450F0.21
BRCAchr8143813484SilentNAL163L0.18
BRCAchr8143809673Missense_MutationnovelP526A0.2
BRCAchr8143791300Missense_Mutationrs782366459E1586K0.27
BRCAchr8143809624Missense_MutationnovelE542G0.24
CESCchr8143813892Silentrs371973612I94I0.58
CESCchr8143795460Missense_MutationNAS1225C0.17
CESCchr8143792811SilentnovelQ1358Q0.26
CESCchr8143809557Silentrs771432032Y564Y0.31
CESCchr8143812307Missense_MutationNAE289Q0.26
CESCchr8143807554Missense_MutationNAE726Q0.27
CESCchr81437910723'UTRnovel0.31
CESCchr8143804783Missense_MutationnovelV932I0.46
CESCchr8143810561Missense_MutationnovelV483A0.39
CESCchr8143813881Missense_MutationnovelP98L0.29
CESCchr8143811222Missense_MutationnovelD344Y0.08
COADchr8143795432Missense_MutationnovelE1234D0.15
COADchr8143804682Frame_Shift_DelNAT966Pfs*90.37
COADchr8143791241SilentnovelG1605G0.38
COADchr8143804813Missense_MutationnovelD922N0.33
COADchr8143805134Missense_MutationnovelT883I0.29
COADchr8143810779Nonsense_MutationnovelW437*0.38
COADchr8143793086Splice_RegionNA0.28
COADchr8143804682Frame_Shift_DelNAT966Pfs*90.59
COADchr8143811181Silentrs200653689T357T0.32
COADchr8143803453Missense_Mutationrs782414337R1178H0.42
COADchr8143812971Intronrs7782111720.37
COADchr8143804682Frame_Shift_DelNAT966Pfs*90.76
COADchr8143812378Missense_MutationnovelL265R0.41
COADchr8143795499Missense_Mutationrs782460123A1212V0.59
COADchr8143814006Missense_Mutationrs753674425R91Q0.11
COADchr8143805375Frame_Shift_DelnovelA803Pfs*1210.21
COADchr8143803903Missense_Mutationrs781998900R1053Q0.38
COADchr8143804682Frame_Shift_DelNAT966Pfs*90.38
COADchr8143809572Silentrs145691551D559D0.52
COADchr8143793050Missense_Mutationrs782736261A1315T0.35
COADchr8143803715Missense_Mutationrs782034055R1116C0.27
COADchr8143795457Missense_MutationNAS1226F0.19
COADchr8143812911SilentNAR231R0.21
COADchr8143813469Splice_Siters753969093X168_splice0.24
ESCAchr8143791213Missense_MutationnovelR1615S0.22
ESCAchr8143806979Missense_MutationnovelL738P0.1
ESCAchr8143813862SilentnovelC104C0.26
ESCAchr8143813863Missense_MutationnovelC104F0.26
GBMchr8143808879Missense_MutationnovelK615N0.52
GBMchr8143810957Missense_Mutationrs780317726E408K0.59
GBMchr8143813883SilentnovelI97I0.09
HNSCchr8143809633Missense_Mutationrs760633347P539L0.11
HNSCchr8143803506SilentnovelV1160V0.45
HNSCchr8143809001Missense_Mutationrs752702092A575T0.36
HNSCchr8143804147Missense_MutationnovelL1007V0.15
HNSCchr8143805213Missense_Mutationrs782057586L857F0.55
HNSCchr8143805214SilentnovelP856P0.56
HNSCchr8143811160Silentrs761055180D364D0.09
HNSCchr8143813678SilentnovelL135L0.16
HNSCchr8143808922Missense_MutationnovelR601Q0.43
HNSCchr8143810928SilentnovelP417P0.16
HNSCchr8143795434Missense_MutationnovelE1234Q0.29
HNSCchr8143810577Missense_MutationnovelP478S0.34
HNSCchr8143792774Missense_MutationNAE1371K0.35
HNSCchr8143809021Missense_Mutationrs761006834T568M0.2
HNSCchr8143795037Splice_SitenovelX1282_splice0.35
KICHchr8143791885Silentrs782007188P1562P0.25
KIRCchr8143792759Missense_Mutationrs746150496R1376C0.25
KIRPchr8143810812Missense_MutationNAD426E0.33
LAMLchr8143809569SilentNAA560A0.69
LGGchr8143813062Missense_MutationNAL204V0.3
LGGchr8143804154Missense_MutationnovelE1004D0.32
LGGchr8143811210Missense_MutationnovelA348T0.64
LGGchr8143812975Intronnovel0.21
LGGchr8143804709Frame_Shift_DelnovelP956Afs*180.23
LGGchr8143811249Missense_MutationnovelV335M0.25
LIHCchr8143810511Missense_Mutationrs759838353P500A0.14
LIHCchr8143808790Nonsense_MutationNAW645*0.24
LIHCchr8143803665SilentNAE1132E0.25
LIHCchr8143813020Intronnovel0.75
LIHCchr8143808960Missense_MutationNAQ588H0.05
LIHCchr8143791388Splice_SitenovelX1583_splice0.65
LIHCchr8143791182Missense_MutationnovelL1625P0.38
LIHCchr8143793052Missense_MutationnovelP1314L0.34
LIHCchr8143812946Missense_Mutationrs754579272R220W0.04
LIHCchr8143809641Silentrs546935238P536P0.78
LIHCchr8143805386Missense_MutationnovelA799V0.14
LUADchr8143810694Missense_MutationNAE466Q0.05
LUADchr8143803480Missense_Mutationrs545423403T1169M0.15
LUADchr8143803897Missense_MutationNAG1055V0.5
LUADchr8143808798SilentNAP642P0.28
LUADchr8143813340Missense_MutationNAD180H0.25
LUADchr8143803676Missense_MutationNAP1129S0.44
LUADchr8143813646Missense_MutationnovelD146G0.32
LUADchr8143809652Missense_MutationNAE533K0.09
LUADchr8143808625Missense_MutationNAS700F0.34
LUADchr8143806982Missense_MutationNAG737V0.67
LUSCchr8143795047Missense_MutationnovelS1279R0.15
LUSCchr8143812884Silentrs200348011G240G0.12
LUSCchr8143803542Silentrs150206819D1148D0.16
LUSCchr8143792264SilentNAL1490L0.26
LUSCchr8143810500SilentNAG503G0.1
LUSCchr8143804111Missense_MutationNAV1019I0.6
LUSCchr8143809652Missense_MutationNAE533K0.07
LUSCchr8143805177Nonsense_MutationnovelE869*0.63
LUSCchr8143810920Missense_MutationnovelP420L0.14
LUSCchr8143792621Nonsense_MutationNAQ1398*0.5
LUSCchr8143795046Missense_Mutationrs144293240V1280M0.22
LUSCchr8143808642Silentrs759496742K694K0.54
LUSCchr8143792674Intronnovel0.28
LUSCchr8143808966Missense_MutationnovelE586D0.54
LUSCchr8143812921Missense_MutationnovelS228W0.07
LUSCchr8143808950Missense_MutationNAP592S0.41
LUSCchr8143808981Silentrs151205998D581D0.06
LUSCchr8143812284SilentNAL296L0.15
LUSCchr8143815305Missense_MutationnovelS23L0.28
LUSCchr8143811292Missense_MutationNAD320E0.11
LUSCchr8143803679Missense_Mutationrs201727511D1128N0.48
MESOchr8143810944Missense_MutationnovelT412I0.22
MESOchr8143808918SilentnovelL602L0.18
OVchr8143809593Frame_Shift_DelnovelT553Lfs*1640.17
OVchr8143812818In_Frame_DelnovelR256_I262del0.24
OVchr8143808916Missense_MutationNAI603N0.39
OVchr8143812926Silentrs765553733D226D0.35
OVchr8143810599Silentrs369221376L470L0.44
OVchr8143808895Frame_Shift_InsNAY610Lfs*260.15
OVchr8143795321Missense_MutationnovelP1243T0.15
OVchr8143795323In_Frame_InsnovelL1242delinsPHLKV0.12
PAADchr8143808989Missense_Mutationrs370311838G579R0.06
PAADchr8143809711Missense_Mutationrs550678185R513Q0.18
PAADchr8143814094Missense_MutationNAR62C0.26
PAADchr8143792681Intronnovel0.19
PAADchr8143803443Silentrs536818456G1181G0.18
PAADchr8143808634Missense_MutationNAA697V0.17
PAADchr8143811239Missense_MutationnovelS338I0.18
PAADchr8143806964Missense_MutationnovelA743V0.38
PCPGchr8143804714Missense_MutationnovelP955S0.52
PCPGchr8143806450Missense_MutationnovelP768R0.46
PCPGchr8143808625Missense_MutationNAS700F0.54
PCPGchr8143808836Nonsense_MutationnovelQ630*0.39
PCPGchr8143809016Missense_MutationnovelH570Y0.51
PCPGchr8143810728SilentnovelP454P0.48
PCPGchr8143812972Intronrs7474818530.6
PCPGchr8143813361Missense_MutationnovelL173V0.34
PRADchr8143810915Missense_MutationnovelP422S0.19
PRADchr8143812926Silentrs765553733D226D0.24
READchr8143804786Missense_Mutationrs369239046A931T0.42
READchr8143792764Frame_Shift_DelNAP1374Lfs*1330.25
SARCchr8143804120Missense_MutationnovelL1016I0.04
SARCchr81437911273'UTRnovel0.37
SARCchr8143793906SilentnovelG1301G0.05
SKCMchr8143795333Missense_MutationnovelE1239K0.32
SKCMchr8143804581Missense_MutationNAP999L0.81
SKCMchr8143792250Missense_MutationNAA1495V0.31
SKCMchr8143803455SilentNAL1177L0.4
SKCMchr8143792080Missense_Mutationrs782160875S1523F0.14
SKCMchr8143808762SilentNAA654A0.3
SKCMchr8143795504SilentnovelP1210P0.3
SKCMchr8143803650SilentnovelS1137S0.22
SKCMchr8143803652Missense_MutationnovelS1137T0.22
SKCMchr8143812999Intronrs5632949830.31
SKCMchr8143792844SilentNAA1347A0.35
SKCMchr8143804721SilentnovelG952G0.35
SKCMchr8143804102Missense_MutationNAS1022T0.5
SKCMchr8143792826Silentrs781850430S1353S0.27
SKCMchr8143803538Missense_Mutationrs781893306R1150W0.47
SKCMchr8143811197Missense_MutationNAP352L0.3
SKCMchr8143792826Silentrs781850430S1353S0.19
SKCMchr8143811054Silentrs775237815F375F0.38
SKCMchr8143792764Missense_MutationnovelP1374L0.37
SKCMchr8143792765Missense_MutationnovelP1374S0.37
SKCMchr8143804577SilentNAY1000Y0.26
SKCMchr8143791412Missense_Mutationrs782291991S1575F0.2
SKCMchr8143813682Missense_MutationNAA134V0.36
SKCMchr8143811062SilentNAL373L0.21
SKCMchr8143805160Missense_MutationNAF874L0.2
SKCMchr8143811035Missense_MutationNAL382F0.22
SKCMchr8143812280Missense_MutationNAE298K0.25
SKCMchr8143795073Missense_MutationNAL1271V0.17
SKCMchr8143813480Missense_MutationNAS165P0.09
STADchr8143809658Missense_MutationNAV531I0.21
STADchr8143803468Missense_Mutationrs781997894A1173V0.23
STADchr8143808635Frame_Shift_DelnovelA697Pfs*200.29
STADchr8143813819Missense_Mutationrs751075643R119G0.19
STADchr8143795294Missense_Mutationrs769393665E1252K0.28
STADchr8143810564Missense_MutationNAK482R0.19
STADchr8143809641Silentrs546935238P536P0.28
STADchr8143792599Missense_Mutationrs782653455R1405Q0.19
STADchr8143803681Missense_Mutationrs782715094R1127H0.3
STADchr8143813836Missense_MutationnovelS113N0.24
STADchr8143803694Missense_Mutationrs565349797A1123T0.32
STADchr8143811298Silentrs145794409N318N0.34
STADchr8143813700Missense_Mutationrs375530176R128H0.21
STADchr8143792708Missense_MutationNAA1393T0.12
STADchr8143795493Missense_MutationNAG1214D0.16
STADchr8143792789Missense_Mutationrs200983191R1366C0.14
STADchr8143805005Missense_Mutationrs781909065V894I0.38
STADchr8143810690Missense_MutationNAK467M0.2
STADchr8143811049Missense_MutationnovelL377P0.42
STADchr8143810990Missense_Mutationrs767960644R397W0.16
STADchr8143805209Missense_Mutationrs782812033R858H0.33
STADchr8143791712Intronnovel0.1
STADchr8143805178Silentrs767046372S868S0.14
STADchr8143792218Splice_SiteNAX1505_splice0.28
STADchr8143795077Silentrs782559503R1269R0.17
STADchr8143803916Missense_Mutationrs538757774R1049C0.25
STADchr8143809658Missense_MutationNAV531I0.2
STADchr8143792111Missense_MutationnovelA1513T0.26
STADchr8143809002SilentNAD574D0.22
STADchr8143809010Missense_Mutationrs374302020A572S0.05
STADchr8143792758Missense_Mutationrs781874101R1376H0.31
STADchr8143804682Frame_Shift_DelNAT966Pfs*90.23
STADchr8143808797Missense_MutationNAG643W0.08
STADchr8143795499Missense_MutationnovelA1212E0.36
THCAchr8143791891SilentnovelT1560T0.24
THYMchr8143812335Silentrs753383025C279C0.11
UCECchr8143803503SilentNAN1161N0.6
UCECchr8143792286Missense_MutationNAR1483H0.5
UCECchr8143804081Missense_MutationnovelF1029I0.16
UCECchr8143795079Missense_Mutationrs782334485R1269C0.44
UCECchr8143804109Silentrs782071220V1019V0.26
UCECchr8143804811Silentrs150215022D922D0.51
UCECchr8143808656Missense_MutationnovelE690K0.16
UCECchr8143791197Missense_MutationnovelP1620L0.48
UCECchr8143792974Splice_SitenovelX1339_splice0.56
UCECchr8143795427Frame_Shift_DelnovelP1236Qfs*290.44
UCECchr8143792323SilentnovelL1471L0.8
UCECchr8143795109Missense_Mutationrs781956229R1259W0.44
UCECchr8143793941Missense_MutationnovelG1290R0.09
UCECchr8143793049Missense_MutationnovelA1315V0.57
UCECchr8143791726IntronNA0.26
UCECchr8143808738Missense_MutationNAE662D0.14
UCECchr8143812343Missense_MutationNAR277W0.32
UCECchr8143812826Missense_Mutationrs201460152D260N0.37
UCECchr8143805304SilentnovelT826T0.42
UCECchr8143804099Missense_Mutationrs140972127D1023N0.09
UCECchr8143812332Missense_MutationNAE280D0.24
UCECchr8143791277SilentnovelL1593L0.25
UCECchr8143808698Missense_MutationnovelE676K0.5
UCECchr8143810696Missense_MutationnovelA465D0.26
UCECchr8143814000Splice_SitenovelX93_splice0.23
UCECchr8143804144Missense_Mutationrs782546577P1008S0.32
UCECchr8143813844Silentrs367987093A110A0.33
UCECchr8143804130Silentrs782537656G1012G0.2
UCECchr8143809584Silentrs145908680G555G0.2
UCECchr8143792627SilentNAL1396L0.39
UCECchr8143803852Missense_Mutationrs781978489T1070M0.45
UCECchr8143795279Missense_Mutationrs200246577A1257S0.46
UCECchr8143807568Missense_MutationnovelR721H0.26
UCECchr8143809568Missense_Mutationrs775403235E561K0.2
UCECchr8143811052Missense_Mutationrs769491305A376V0.26
UCECchr8143807568Missense_MutationnovelR721H0.54
UCECchr8143812946Missense_Mutationrs754579272R220W0.38
UCECchr8143805112Splice_RegionnovelA890A0.28
UCECchr8143804100Silentrs565642007S1022S0.39
UCECchr8143804678Missense_Mutationrs782463802A967T0.38
UCECchr8143795527Missense_MutationnovelS1203P0.55
UCECchr8143805182Missense_Mutationrs782216516R867H0.48
UCECchr8143808972SilentnovelI584I0.35
UCECchr8143812838Missense_Mutationrs766529502R256W0.34
UCECchr8143814083SilentnovelG65G0.15
UCECchr8143813082Missense_MutationnovelP197H0.34
UCECchr8143813317Missense_MutationnovelE187D0.21
UCECchr8143814110Frame_Shift_InsnovelR57Pfs*400.29
UCECchr8143808621Silentrs145142316A701A0.18
UCECchr8143809579Missense_MutationNAE557G0.26
UCECchr8143809711Missense_Mutationrs550678185R513Q0.44
UCECchr8143812989Intronrs5595757650.29
UCECchr8143808635Frame_Shift_DelnovelA697Pfs*200.58
UCECchr8143805374Missense_MutationNAA803V0.75
UCECchr8143795319SilentnovelP1243P0.37
UCECchr8143792134Splice_SitenovelX1505_splice0.15
UCECchr8143804131Frame_Shift_DelnovelG1012Afs*500.29
UCECchr8143813836Missense_MutationnovelS113N0.07
UCECchr81437909653'UTRnovel0.29
UCECchr8143809709Missense_MutationNAL514M0.3
UCECchr8143811299Missense_Mutationrs746406445N318S0.5
UCECchr8143813521Missense_MutationnovelA151V0.57
UCECchr8143795526Missense_MutationnovelS1203Y0.53
UCECchr8143813847Silentrs140033768I109I0.29
UCECchr8143803852Missense_Mutationrs781978489T1070M0.46
UCSchr8143803385Nonsense_MutationnovelE1201*0.14
UCSchr8143810535Missense_MutationnovelR492W0.1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.250.018626
KIRCAMP0.11930.15559
LGGDEL0.04680.014004
SARCAMP0.26070.18425
SKCMAMP0.4552.8957e-05
TGCTAMP0.560.13696
UVMAMP0.73758.8879e-13

Survival Analysis
CancerP-value Q-value
KIRC0.00023

Kaplan-Meier Survival Analysis

STAD0.0011

Kaplan-Meier Survival Analysis

SARC0.016

Kaplan-Meier Survival Analysis

MESO0.0051

Kaplan-Meier Survival Analysis

ACC0.00014

Kaplan-Meier Survival Analysis

SKCM0.017

Kaplan-Meier Survival Analysis

LUSC0.026

Kaplan-Meier Survival Analysis

CESC0.00073

Kaplan-Meier Survival Analysis

LIHC0.0072

Kaplan-Meier Survival Analysis

LGG0.0044

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000180900 (Gene tree)
Gene ID
23513
Gene Symbol
SCRIB
Alias
KIAA0147|SCRB1|Vartul
Full Name
scribble planar cell polarity protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
24,460 bases
Position
chr8:143,790,920-143,815,379
Accession
30377
RBP type
non-canonical RBP
Summary
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000356994SCRIB-2025218-ENSP000003494861655 (aa)-Q14160
ENST00000525051SCRIB-2041685--- (aa)--
ENST00000546337SCRIB-208516--- (aa)--
ENST00000320476SCRIB-2015143-ENSP000003229381630 (aa)-Q14160
ENST00000531942SCRIB-207421-ENSP00000433546140 (aa)-H0YDF9
ENST00000526832SCRIB-2052189-ENSP00000431519650 (aa)-H0YCG0
ENST00000531163SCRIB-206538--- (aa)--
ENST00000377533SCRIB-2035108-ENSP000003667561549 (aa)-Q14160
Gene Model
Click here to download ENSG00000180900's gene model file
Pathways
Pathway IDPathway NameSource
hsa04390Hippo signaling pathwayKEGG
hsa04530Tight junctionKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05203Viral carcinogenesisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180900's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001843neural tube closure22095531.IMPProcess
GO:0001921positive regulation of receptor recycling15775968.IMPProcess
GO:0005515protein binding15182672.15649318.15775968.15975580.16103886.16137684.16611247.18716323.19041750.19439659.19555689.19615732.20622900.21132015.21525870.21701506.22078877.24550280.28169360.29144123.30126976.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005886plasma membrane15182672.28169360.IDAComponent
GO:0005886plasma membrane16611247.IDAComponent
GO:0005911cell-cell junction21873635.IBAComponent
GO:0005911cell-cell junction15649318.IDAComponent
GO:0005913cell-cell adherens junction21873635.IBAComponent
GO:0005913cell-cell adherens junction16965391.IDAComponent
GO:0008283cell proliferation16965391.IDAProcess
GO:0008328ionotropic glutamate receptor complex21873635.IBAComponent
GO:0014069postsynaptic density21873635.IBAComponent
GO:0016080synaptic vesicle targeting-IEAProcess
GO:0016323basolateral plasma membrane21873635.IBAComponent
GO:0016477cell migration18716323.IMPProcess
GO:0021747cochlear nucleus development-IEAProcess
GO:0030027lamellipodium-IEAComponent
GO:0030054cell junction21873635.IBAComponent
GO:0030054cell junction-IDAComponent
GO:0031252cell leading edge18716323.IDAComponent
GO:0034750Scrib-APC-beta-catenin complex16611247.IDAComponent
GO:0035089establishment of apical/basal cell polarity19041750.IMPProcess
GO:0035255ionotropic glutamate receptor binding21873635.IBAFunction
GO:0035748myelin sheath abaxonal region-IEAComponent
GO:0039502suppression by virus of host type I interferon-mediated signaling pathway-IEAProcess
GO:0039563suppression by virus of host STAT1 activity-IEAProcess
GO:0039564suppression by virus of host STAT2 activity-IEAProcess
GO:0042060wound healing-IEAProcess
GO:0042734presynaptic membrane15182672.IDAComponent
GO:0043065positive regulation of apoptotic process19041750.IMPProcess
GO:0043113receptor clustering21873635.IBAProcess
GO:0043615astrocyte cell migration-IEAProcess
GO:0044291cell-cell contact zone-IEAComponent
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity21873635.IBAProcess
GO:0045202synapse21873635.IBAComponent
GO:0045211postsynaptic membrane21873635.IBAComponent
GO:0045211postsynaptic membrane15182672.IDAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0045930negative regulation of mitotic cell cycle16965391.IDAProcess
GO:0048488synaptic vesicle endocytosis-IEAProcess
GO:0050918positive chemotaxis18716323.IMPProcess
GO:0060088auditory receptor cell stereocilium organization-IEAProcess
GO:0060561apoptotic process involved in morphogenesis19041750.IMPProcess
GO:0060603mammary gland duct morphogenesis-ISSProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071896protein localization to adherens junction16611247.IMPProcess
GO:0090630activation of GTPase activity19041750.IMPProcess
GO:0097120receptor localization to synapse21873635.IBAProcess
GO:0098609cell-cell adhesion21873635.IBAProcess
GO:0098609cell-cell adhesion16344308.IGIProcess
GO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane21873635.IBAProcess
GO:0098968neurotransmitter receptor transport postsynaptic membrane to endosome21873635.IBAProcess
GO:0098978glutamatergic synapse-IEAComponent
GO:0099147extrinsic component of postsynaptic density membrane-IEAComponent
GO:0099149regulation of postsynaptic neurotransmitter receptor internalization-IEAProcess
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