EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28460446	The cell polarity protein Scrib functions as a tumor suppressor in liver cancer.	Oncotarget	2017 Apr 18	Kapil S	doi: 10.18632/oncotarget.15713.
23730214	CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells.	Neoplasia	2013 Jun	Metodieva G	-
27562784	Expression of cell polarity protein scribble differently affects prognosis in primary tumor and lymph node metastasis of breast cancer patients.	Breast Cancer	2017 May	Sakakibara J	doi: 10.1007/s12282-016-0715-2
21549346	Aberrant overexpression of the cell polarity module scribble in human cancer.	Am J Pathol	2011 Jun	Vaira V	doi: 10.1016/j.ajpath.2011.02.028
15806148	Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.	Oncogene	2005 Jun 23	Navarro C	-
20622900	The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction.	Oncogene	2010 Sep 23	Nagasaka K	doi: 10.1038/onc.2010.265
15261375	[hScrib: a potential novel tumor suppressor].	Pathol Biol (Paris)	2004 Jul	Borg JP	-
16344308	The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin.	J Cell Biol	2005 Dec 19	Qin Y	-
27380321	ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.	Nat Chem Biol	2016 Sep	Chen B	doi: 10.1038/nchembio.2119
29152770	Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness.	Hepatology	2018 May	Wan S	doi: 10.1002/hep.29669
21086040	No association of polymorphisms in the cell polarity gene SCRIB with breast cancer risk in German population.	Breast Cancer Res Treat	2011 Feb	Zhang C	doi: 10.1007/s10549-010-1253-9
27428426	Decreased Usage of Specific Scrib Exons Defines a More Malignant Phenotype of Breast Cancer With Worsened Survival.	EBioMedicine	2016 Jun	Metodieva G	doi: 10.1016/j.ebiom.2016.05.009
20939435	hScrib, a human homolog of Drosophila neoplastic tumor suppressor, is involved in the progress of endometrial cancer.	Oncol Res	2010	Ouyang Z	-
20936341	No association of polymorphisms in the cell polarity gene SCRIB with breast cancer risk.	Breast Cancer Res Treat	2011 May	D??nnebier T	doi: 10.1007/s10549-010-1194-3
21965329	SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.	J Clin Invest	2011 Nov	Pearson HB	doi: 10.1172/JCI58509
19041750	Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.	Cell	2008 Nov 28	Zhan L	doi: 10.1016/j.cell.2008.09.045.
16619250	Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.	Int J Cancer	2006 Sep 15	Gardiol D	-
22179838	A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.	Oncogene	2012 Aug 9	Anastas JN	doi: 10.1038/onc.2011.528
29144123	The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1.	Biochemistry	2018 Jan 9	Sundell GN	doi: 10.1021/acs.biochem.7b00965

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr8	143810767	Silent	novel	P441P	0.42
BLCA	chr8	143810789	Missense_Mutation	rs779811140	S434L	0.12
BLCA	chr8	143813340	Missense_Mutation	NA	D180N	0.13
BLCA	chr8	143813523	Silent	rs773591724	L150L	0.66
BLCA	chr8	143812859	Silent	NA	L249L	0.13
BLCA	chr8	143793944	Missense_Mutation	novel	G1289R	0.13
BLCA	chr8	143812913	Missense_Mutation	novel	R231G	0.35
BLCA	chr8	143815326	Missense_Mutation	novel	S16L	0.25
BLCA	chr8	143813349	Missense_Mutation	novel	E177Q	0.2
BLCA	chr8	143804776	Missense_Mutation	NA	L934Q	0.21
BLCA	chr8	143807563	Missense_Mutation	novel	E723Q	0.29
BLCA	chr8	143812886	Missense_Mutation	novel	G240R	0.16
BLCA	chr8	143812977	Intron	NA		0.35
BLCA	chr8	143809568	Missense_Mutation	rs775403235	E561K	0.27
BLCA	chr8	143815217	Silent	rs751405745	P52P	0.42
BLCA	chr8	143812307	Missense_Mutation	novel	E289K	0.18
BLCA	chr8	143792808	Silent	novel	K1359K	0.85
BLCA	chr8	143810529	Missense_Mutation	novel	E494K	0.23
BLCA	chr8	143813883	Silent	novel	I97I	0.48
BLCA	chr8	143804791	Missense_Mutation	novel	D929G	0.25
BLCA	chr8	143807569	Missense_Mutation	rs782621145	R721C	0.28
BLCA	chr8	143810544	Missense_Mutation	rs137872634	E489K	0.3
BLCA	chr8	143807578	Missense_Mutation	NA	E718Q	0.09
BLCA	chr8	143803532	Missense_Mutation	rs782093618	R1152C	0.38
BLCA	chr8	143809701	Silent	rs538041646	A516A	0.22
BLCA	chr8	143813523	Silent	rs773591724	L150L	0.11
BLCA	chr8	143815243	Missense_Mutation	novel	D44H	0.24
BRCA	chr8	143814111	Frame_Shift_Del	NA	*F56Sfs4**	0.18
BRCA	chr8	143803765	Missense_Mutation	rs781995997	R1099Q	0.38
BRCA	chr8	143795305	Missense_Mutation	novel	H1248P	0.64
BRCA	chr8	143808685	Frame_Shift_Del	novel	*N680Tfs37**	0.09
BRCA	chr8	143808737	Missense_Mutation	NA	E663Q	0.38
BRCA	chr8	143810740	Silent	rs748875240	F450F	0.21
BRCA	chr8	143813484	Silent	NA	L163L	0.18
BRCA	chr8	143809673	Missense_Mutation	novel	P526A	0.2
BRCA	chr8	143791300	Missense_Mutation	rs782366459	E1586K	0.27
BRCA	chr8	143809624	Missense_Mutation	novel	E542G	0.24
CESC	chr8	143813892	Silent	rs371973612	I94I	0.58
CESC	chr8	143795460	Missense_Mutation	NA	S1225C	0.17
CESC	chr8	143792811	Silent	novel	Q1358Q	0.26
CESC	chr8	143809557	Silent	rs771432032	Y564Y	0.31
CESC	chr8	143812307	Missense_Mutation	NA	E289Q	0.26
CESC	chr8	143807554	Missense_Mutation	NA	E726Q	0.27
CESC	chr8	143791072	3'UTR	novel		0.31
CESC	chr8	143804783	Missense_Mutation	novel	V932I	0.46
CESC	chr8	143810561	Missense_Mutation	novel	V483A	0.39
CESC	chr8	143813881	Missense_Mutation	novel	P98L	0.29
CESC	chr8	143811222	Missense_Mutation	novel	D344Y	0.08
COAD	chr8	143795432	Missense_Mutation	novel	E1234D	0.15
COAD	chr8	143804682	Frame_Shift_Del	NA	*T966Pfs9**	0.37
COAD	chr8	143791241	Silent	novel	G1605G	0.38
COAD	chr8	143804813	Missense_Mutation	novel	D922N	0.33
COAD	chr8	143805134	Missense_Mutation	novel	T883I	0.29
COAD	chr8	143810779	Nonsense_Mutation	novel	W437*	0.38
COAD	chr8	143793086	Splice_Region	NA		0.28
COAD	chr8	143804682	Frame_Shift_Del	NA	*T966Pfs9**	0.59
COAD	chr8	143811181	Silent	rs200653689	T357T	0.32
COAD	chr8	143803453	Missense_Mutation	rs782414337	R1178H	0.42
COAD	chr8	143812971	Intron	rs778211172		0.37
COAD	chr8	143804682	Frame_Shift_Del	NA	*T966Pfs9**	0.76
COAD	chr8	143812378	Missense_Mutation	novel	L265R	0.41
COAD	chr8	143795499	Missense_Mutation	rs782460123	A1212V	0.59
COAD	chr8	143814006	Missense_Mutation	rs753674425	R91Q	0.11
COAD	chr8	143805375	Frame_Shift_Del	novel	*A803Pfs121**	0.21
COAD	chr8	143803903	Missense_Mutation	rs781998900	R1053Q	0.38
COAD	chr8	143804682	Frame_Shift_Del	NA	*T966Pfs9**	0.38
COAD	chr8	143809572	Silent	rs145691551	D559D	0.52
COAD	chr8	143793050	Missense_Mutation	rs782736261	A1315T	0.35
COAD	chr8	143803715	Missense_Mutation	rs782034055	R1116C	0.27
COAD	chr8	143795457	Missense_Mutation	NA	S1226F	0.19
COAD	chr8	143812911	Silent	NA	R231R	0.21
COAD	chr8	143813469	Splice_Site	rs753969093	X168_splice	0.24
ESCA	chr8	143791213	Missense_Mutation	novel	R1615S	0.22
ESCA	chr8	143806979	Missense_Mutation	novel	L738P	0.1
ESCA	chr8	143813862	Silent	novel	C104C	0.26
ESCA	chr8	143813863	Missense_Mutation	novel	C104F	0.26
GBM	chr8	143808879	Missense_Mutation	novel	K615N	0.52
GBM	chr8	143810957	Missense_Mutation	rs780317726	E408K	0.59
GBM	chr8	143813883	Silent	novel	I97I	0.09
HNSC	chr8	143809633	Missense_Mutation	rs760633347	P539L	0.11
HNSC	chr8	143803506	Silent	novel	V1160V	0.45
HNSC	chr8	143809001	Missense_Mutation	rs752702092	A575T	0.36
HNSC	chr8	143804147	Missense_Mutation	novel	L1007V	0.15
HNSC	chr8	143805213	Missense_Mutation	rs782057586	L857F	0.55
HNSC	chr8	143805214	Silent	novel	P856P	0.56
HNSC	chr8	143811160	Silent	rs761055180	D364D	0.09
HNSC	chr8	143813678	Silent	novel	L135L	0.16
HNSC	chr8	143808922	Missense_Mutation	novel	R601Q	0.43
HNSC	chr8	143810928	Silent	novel	P417P	0.16
HNSC	chr8	143795434	Missense_Mutation	novel	E1234Q	0.29
HNSC	chr8	143810577	Missense_Mutation	novel	P478S	0.34
HNSC	chr8	143792774	Missense_Mutation	NA	E1371K	0.35
HNSC	chr8	143809021	Missense_Mutation	rs761006834	T568M	0.2
HNSC	chr8	143795037	Splice_Site	novel	X1282_splice	0.35
KICH	chr8	143791885	Silent	rs782007188	P1562P	0.25
KIRC	chr8	143792759	Missense_Mutation	rs746150496	R1376C	0.25
KIRP	chr8	143810812	Missense_Mutation	NA	D426E	0.33
LAML	chr8	143809569	Silent	NA	A560A	0.69
LGG	chr8	143813062	Missense_Mutation	NA	L204V	0.3
LGG	chr8	143804154	Missense_Mutation	novel	E1004D	0.32
LGG	chr8	143811210	Missense_Mutation	novel	A348T	0.64
LGG	chr8	143812975	Intron	novel		0.21
LGG	chr8	143804709	Frame_Shift_Del	novel	*P956Afs18**	0.23
LGG	chr8	143811249	Missense_Mutation	novel	V335M	0.25
LIHC	chr8	143810511	Missense_Mutation	rs759838353	P500A	0.14
LIHC	chr8	143808790	Nonsense_Mutation	NA	W645*	0.24
LIHC	chr8	143803665	Silent	NA	E1132E	0.25
LIHC	chr8	143813020	Intron	novel		0.75
LIHC	chr8	143808960	Missense_Mutation	NA	Q588H	0.05
LIHC	chr8	143791388	Splice_Site	novel	X1583_splice	0.65
LIHC	chr8	143791182	Missense_Mutation	novel	L1625P	0.38
LIHC	chr8	143793052	Missense_Mutation	novel	P1314L	0.34
LIHC	chr8	143812946	Missense_Mutation	rs754579272	R220W	0.04
LIHC	chr8	143809641	Silent	rs546935238	P536P	0.78
LIHC	chr8	143805386	Missense_Mutation	novel	A799V	0.14
LUAD	chr8	143810694	Missense_Mutation	NA	E466Q	0.05
LUAD	chr8	143803480	Missense_Mutation	rs545423403	T1169M	0.15
LUAD	chr8	143803897	Missense_Mutation	NA	G1055V	0.5
LUAD	chr8	143808798	Silent	NA	P642P	0.28
LUAD	chr8	143813340	Missense_Mutation	NA	D180H	0.25
LUAD	chr8	143803676	Missense_Mutation	NA	P1129S	0.44
LUAD	chr8	143813646	Missense_Mutation	novel	D146G	0.32
LUAD	chr8	143809652	Missense_Mutation	NA	E533K	0.09
LUAD	chr8	143808625	Missense_Mutation	NA	S700F	0.34
LUAD	chr8	143806982	Missense_Mutation	NA	G737V	0.67
LUSC	chr8	143795047	Missense_Mutation	novel	S1279R	0.15
LUSC	chr8	143812884	Silent	rs200348011	G240G	0.12
LUSC	chr8	143803542	Silent	rs150206819	D1148D	0.16
LUSC	chr8	143792264	Silent	NA	L1490L	0.26
LUSC	chr8	143810500	Silent	NA	G503G	0.1
LUSC	chr8	143804111	Missense_Mutation	NA	V1019I	0.6
LUSC	chr8	143809652	Missense_Mutation	NA	E533K	0.07
LUSC	chr8	143805177	Nonsense_Mutation	novel	E869*	0.63
LUSC	chr8	143810920	Missense_Mutation	novel	P420L	0.14
LUSC	chr8	143792621	Nonsense_Mutation	NA	Q1398*	0.5
LUSC	chr8	143795046	Missense_Mutation	rs144293240	V1280M	0.22
LUSC	chr8	143808642	Silent	rs759496742	K694K	0.54
LUSC	chr8	143792674	Intron	novel		0.28
LUSC	chr8	143808966	Missense_Mutation	novel	E586D	0.54
LUSC	chr8	143812921	Missense_Mutation	novel	S228W	0.07
LUSC	chr8	143808950	Missense_Mutation	NA	P592S	0.41
LUSC	chr8	143808981	Silent	rs151205998	D581D	0.06
LUSC	chr8	143812284	Silent	NA	L296L	0.15
LUSC	chr8	143815305	Missense_Mutation	novel	S23L	0.28
LUSC	chr8	143811292	Missense_Mutation	NA	D320E	0.11
LUSC	chr8	143803679	Missense_Mutation	rs201727511	D1128N	0.48
MESO	chr8	143810944	Missense_Mutation	novel	T412I	0.22
MESO	chr8	143808918	Silent	novel	L602L	0.18
OV	chr8	143809593	Frame_Shift_Del	novel	*T553Lfs164**	0.17
OV	chr8	143812818	In_Frame_Del	novel	R256_I262del	0.24
OV	chr8	143808916	Missense_Mutation	NA	I603N	0.39
OV	chr8	143812926	Silent	rs765553733	D226D	0.35
OV	chr8	143810599	Silent	rs369221376	L470L	0.44
OV	chr8	143808895	Frame_Shift_Ins	NA	*Y610Lfs26**	0.15
OV	chr8	143795321	Missense_Mutation	novel	P1243T	0.15
OV	chr8	143795323	In_Frame_Ins	novel	L1242delinsPHLKV	0.12
PAAD	chr8	143808989	Missense_Mutation	rs370311838	G579R	0.06
PAAD	chr8	143809711	Missense_Mutation	rs550678185	R513Q	0.18
PAAD	chr8	143814094	Missense_Mutation	NA	R62C	0.26
PAAD	chr8	143792681	Intron	novel		0.19
PAAD	chr8	143803443	Silent	rs536818456	G1181G	0.18
PAAD	chr8	143808634	Missense_Mutation	NA	A697V	0.17
PAAD	chr8	143811239	Missense_Mutation	novel	S338I	0.18
PAAD	chr8	143806964	Missense_Mutation	novel	A743V	0.38
PCPG	chr8	143804714	Missense_Mutation	novel	P955S	0.52
PCPG	chr8	143806450	Missense_Mutation	novel	P768R	0.46
PCPG	chr8	143808625	Missense_Mutation	NA	S700F	0.54
PCPG	chr8	143808836	Nonsense_Mutation	novel	Q630*	0.39
PCPG	chr8	143809016	Missense_Mutation	novel	H570Y	0.51
PCPG	chr8	143810728	Silent	novel	P454P	0.48
PCPG	chr8	143812972	Intron	rs747481853		0.6
PCPG	chr8	143813361	Missense_Mutation	novel	L173V	0.34
PRAD	chr8	143810915	Missense_Mutation	novel	P422S	0.19
PRAD	chr8	143812926	Silent	rs765553733	D226D	0.24
READ	chr8	143804786	Missense_Mutation	rs369239046	A931T	0.42
READ	chr8	143792764	Frame_Shift_Del	NA	*P1374Lfs133**	0.25
SARC	chr8	143804120	Missense_Mutation	novel	L1016I	0.04
SARC	chr8	143791127	3'UTR	novel		0.37
SARC	chr8	143793906	Silent	novel	G1301G	0.05
SKCM	chr8	143795333	Missense_Mutation	novel	E1239K	0.32
SKCM	chr8	143804581	Missense_Mutation	NA	P999L	0.81
SKCM	chr8	143792250	Missense_Mutation	NA	A1495V	0.31
SKCM	chr8	143803455	Silent	NA	L1177L	0.4
SKCM	chr8	143792080	Missense_Mutation	rs782160875	S1523F	0.14
SKCM	chr8	143808762	Silent	NA	A654A	0.3
SKCM	chr8	143795504	Silent	novel	P1210P	0.3
SKCM	chr8	143803650	Silent	novel	S1137S	0.22
SKCM	chr8	143803652	Missense_Mutation	novel	S1137T	0.22
SKCM	chr8	143812999	Intron	rs563294983		0.31
SKCM	chr8	143792844	Silent	NA	A1347A	0.35
SKCM	chr8	143804721	Silent	novel	G952G	0.35
SKCM	chr8	143804102	Missense_Mutation	NA	S1022T	0.5
SKCM	chr8	143792826	Silent	rs781850430	S1353S	0.27
SKCM	chr8	143803538	Missense_Mutation	rs781893306	R1150W	0.47
SKCM	chr8	143811197	Missense_Mutation	NA	P352L	0.3
SKCM	chr8	143792826	Silent	rs781850430	S1353S	0.19
SKCM	chr8	143811054	Silent	rs775237815	F375F	0.38
SKCM	chr8	143792764	Missense_Mutation	novel	P1374L	0.37
SKCM	chr8	143792765	Missense_Mutation	novel	P1374S	0.37
SKCM	chr8	143804577	Silent	NA	Y1000Y	0.26
SKCM	chr8	143791412	Missense_Mutation	rs782291991	S1575F	0.2
SKCM	chr8	143813682	Missense_Mutation	NA	A134V	0.36
SKCM	chr8	143811062	Silent	NA	L373L	0.21
SKCM	chr8	143805160	Missense_Mutation	NA	F874L	0.2
SKCM	chr8	143811035	Missense_Mutation	NA	L382F	0.22
SKCM	chr8	143812280	Missense_Mutation	NA	E298K	0.25
SKCM	chr8	143795073	Missense_Mutation	NA	L1271V	0.17
SKCM	chr8	143813480	Missense_Mutation	NA	S165P	0.09
STAD	chr8	143809658	Missense_Mutation	NA	V531I	0.21
STAD	chr8	143803468	Missense_Mutation	rs781997894	A1173V	0.23
STAD	chr8	143808635	Frame_Shift_Del	novel	*A697Pfs20**	0.29
STAD	chr8	143813819	Missense_Mutation	rs751075643	R119G	0.19
STAD	chr8	143795294	Missense_Mutation	rs769393665	E1252K	0.28
STAD	chr8	143810564	Missense_Mutation	NA	K482R	0.19
STAD	chr8	143809641	Silent	rs546935238	P536P	0.28
STAD	chr8	143792599	Missense_Mutation	rs782653455	R1405Q	0.19
STAD	chr8	143803681	Missense_Mutation	rs782715094	R1127H	0.3
STAD	chr8	143813836	Missense_Mutation	novel	S113N	0.24
STAD	chr8	143803694	Missense_Mutation	rs565349797	A1123T	0.32
STAD	chr8	143811298	Silent	rs145794409	N318N	0.34
STAD	chr8	143813700	Missense_Mutation	rs375530176	R128H	0.21
STAD	chr8	143792708	Missense_Mutation	NA	A1393T	0.12
STAD	chr8	143795493	Missense_Mutation	NA	G1214D	0.16
STAD	chr8	143792789	Missense_Mutation	rs200983191	R1366C	0.14
STAD	chr8	143805005	Missense_Mutation	rs781909065	V894I	0.38
STAD	chr8	143810690	Missense_Mutation	NA	K467M	0.2
STAD	chr8	143811049	Missense_Mutation	novel	L377P	0.42
STAD	chr8	143810990	Missense_Mutation	rs767960644	R397W	0.16
STAD	chr8	143805209	Missense_Mutation	rs782812033	R858H	0.33
STAD	chr8	143791712	Intron	novel		0.1
STAD	chr8	143805178	Silent	rs767046372	S868S	0.14
STAD	chr8	143792218	Splice_Site	NA	X1505_splice	0.28
STAD	chr8	143795077	Silent	rs782559503	R1269R	0.17
STAD	chr8	143803916	Missense_Mutation	rs538757774	R1049C	0.25
STAD	chr8	143809658	Missense_Mutation	NA	V531I	0.2
STAD	chr8	143792111	Missense_Mutation	novel	A1513T	0.26
STAD	chr8	143809002	Silent	NA	D574D	0.22
STAD	chr8	143809010	Missense_Mutation	rs374302020	A572S	0.05
STAD	chr8	143792758	Missense_Mutation	rs781874101	R1376H	0.31
STAD	chr8	143804682	Frame_Shift_Del	NA	*T966Pfs9**	0.23
STAD	chr8	143808797	Missense_Mutation	NA	G643W	0.08
STAD	chr8	143795499	Missense_Mutation	novel	A1212E	0.36
THCA	chr8	143791891	Silent	novel	T1560T	0.24
THYM	chr8	143812335	Silent	rs753383025	C279C	0.11
UCEC	chr8	143803503	Silent	NA	N1161N	0.6
UCEC	chr8	143792286	Missense_Mutation	NA	R1483H	0.5
UCEC	chr8	143804081	Missense_Mutation	novel	F1029I	0.16
UCEC	chr8	143795079	Missense_Mutation	rs782334485	R1269C	0.44
UCEC	chr8	143804109	Silent	rs782071220	V1019V	0.26
UCEC	chr8	143804811	Silent	rs150215022	D922D	0.51
UCEC	chr8	143808656	Missense_Mutation	novel	E690K	0.16
UCEC	chr8	143791197	Missense_Mutation	novel	P1620L	0.48
UCEC	chr8	143792974	Splice_Site	novel	X1339_splice	0.56
UCEC	chr8	143795427	Frame_Shift_Del	novel	*P1236Qfs29**	0.44
UCEC	chr8	143792323	Silent	novel	L1471L	0.8
UCEC	chr8	143795109	Missense_Mutation	rs781956229	R1259W	0.44
UCEC	chr8	143793941	Missense_Mutation	novel	G1290R	0.09
UCEC	chr8	143793049	Missense_Mutation	novel	A1315V	0.57
UCEC	chr8	143791726	Intron	NA		0.26
UCEC	chr8	143808738	Missense_Mutation	NA	E662D	0.14
UCEC	chr8	143812343	Missense_Mutation	NA	R277W	0.32
UCEC	chr8	143812826	Missense_Mutation	rs201460152	D260N	0.37
UCEC	chr8	143805304	Silent	novel	T826T	0.42
UCEC	chr8	143804099	Missense_Mutation	rs140972127	D1023N	0.09
UCEC	chr8	143812332	Missense_Mutation	NA	E280D	0.24
UCEC	chr8	143791277	Silent	novel	L1593L	0.25
UCEC	chr8	143808698	Missense_Mutation	novel	E676K	0.5
UCEC	chr8	143810696	Missense_Mutation	novel	A465D	0.26
UCEC	chr8	143814000	Splice_Site	novel	X93_splice	0.23
UCEC	chr8	143804144	Missense_Mutation	rs782546577	P1008S	0.32
UCEC	chr8	143813844	Silent	rs367987093	A110A	0.33
UCEC	chr8	143804130	Silent	rs782537656	G1012G	0.2
UCEC	chr8	143809584	Silent	rs145908680	G555G	0.2
UCEC	chr8	143792627	Silent	NA	L1396L	0.39
UCEC	chr8	143803852	Missense_Mutation	rs781978489	T1070M	0.45
UCEC	chr8	143795279	Missense_Mutation	rs200246577	A1257S	0.46
UCEC	chr8	143807568	Missense_Mutation	novel	R721H	0.26
UCEC	chr8	143809568	Missense_Mutation	rs775403235	E561K	0.2
UCEC	chr8	143811052	Missense_Mutation	rs769491305	A376V	0.26
UCEC	chr8	143807568	Missense_Mutation	novel	R721H	0.54
UCEC	chr8	143812946	Missense_Mutation	rs754579272	R220W	0.38
UCEC	chr8	143805112	Splice_Region	novel	A890A	0.28
UCEC	chr8	143804100	Silent	rs565642007	S1022S	0.39
UCEC	chr8	143804678	Missense_Mutation	rs782463802	A967T	0.38
UCEC	chr8	143795527	Missense_Mutation	novel	S1203P	0.55
UCEC	chr8	143805182	Missense_Mutation	rs782216516	R867H	0.48
UCEC	chr8	143808972	Silent	novel	I584I	0.35
UCEC	chr8	143812838	Missense_Mutation	rs766529502	R256W	0.34
UCEC	chr8	143814083	Silent	novel	G65G	0.15
UCEC	chr8	143813082	Missense_Mutation	novel	P197H	0.34
UCEC	chr8	143813317	Missense_Mutation	novel	E187D	0.21
UCEC	chr8	143814110	Frame_Shift_Ins	novel	*R57Pfs40**	0.29
UCEC	chr8	143808621	Silent	rs145142316	A701A	0.18
UCEC	chr8	143809579	Missense_Mutation	NA	E557G	0.26
UCEC	chr8	143809711	Missense_Mutation	rs550678185	R513Q	0.44
UCEC	chr8	143812989	Intron	rs559575765		0.29
UCEC	chr8	143808635	Frame_Shift_Del	novel	*A697Pfs20**	0.58
UCEC	chr8	143805374	Missense_Mutation	NA	A803V	0.75
UCEC	chr8	143795319	Silent	novel	P1243P	0.37
UCEC	chr8	143792134	Splice_Site	novel	X1505_splice	0.15
UCEC	chr8	143804131	Frame_Shift_Del	novel	*G1012Afs50**	0.29
UCEC	chr8	143813836	Missense_Mutation	novel	S113N	0.07
UCEC	chr8	143790965	3'UTR	novel		0.29
UCEC	chr8	143809709	Missense_Mutation	NA	L514M	0.3
UCEC	chr8	143811299	Missense_Mutation	rs746406445	N318S	0.5
UCEC	chr8	143813521	Missense_Mutation	novel	A151V	0.57
UCEC	chr8	143795526	Missense_Mutation	novel	S1203Y	0.53
UCEC	chr8	143813847	Silent	rs140033768	I109I	0.29
UCEC	chr8	143803852	Missense_Mutation	rs781978489	T1070M	0.46
UCS	chr8	143803385	Nonsense_Mutation	novel	E1201*	0.14
UCS	chr8	143810535	Missense_Mutation	novel	R492W	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1193	0.15559
LGG	DEL	0.0468	0.014004
SARC	AMP	0.2607	0.18425
SKCM	AMP	0.455	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00023	Kaplan-Meier Survival Analysis
STAD	0.0011	Kaplan-Meier Survival Analysis
SARC	0.016	Kaplan-Meier Survival Analysis
MESO	0.0051	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
SKCM	0.017	Kaplan-Meier Survival Analysis
LUSC	0.026	Kaplan-Meier Survival Analysis
CESC	0.00073	Kaplan-Meier Survival Analysis
LIHC	0.0072	Kaplan-Meier Survival Analysis
LGG	0.0044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000180900 (Gene tree)
Gene ID: 23513
Gene Symbol: SCRIB
Alias: KIAA0147|SCRB1|Vartul
Full Name: scribble planar cell polarity protein
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 24,460 bases
Position: chr8:143,790,920-143,815,379
Accession: 30377
Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000356994	SCRIB-202	5218	-	ENSP00000349486	1655 (aa)	-	Q14160
ENST00000525051	SCRIB-204	1685	-	-	- (aa)	-	-
ENST00000546337	SCRIB-208	516	-	-	- (aa)	-	-
ENST00000320476	SCRIB-201	5143	-	ENSP00000322938	1630 (aa)	-	Q14160
ENST00000531942	SCRIB-207	421	-	ENSP00000433546	140 (aa)	-	H0YDF9
ENST00000526832	SCRIB-205	2189	-	ENSP00000431519	650 (aa)	-	H0YCG0
ENST00000531163	SCRIB-206	538	-	-	- (aa)	-	-
ENST00000377533	SCRIB-203	5108	-	ENSP00000366756	1549 (aa)	-	Q14160

Gene Model

Click here to download ENSG00000180900's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04390	Hippo signaling pathway	KEGG
hsa04530	Tight junction	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180900's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001843	neural tube closure	22095531.	IMP	Process
GO:0001921	positive regulation of receptor recycling	15775968.	IMP	Process
GO:0005515	protein binding	15182672.15649318.15775968.15975580.16103886.16137684.16611247.18716323.19041750.19439659.19555689.19615732.20622900.21132015.21525870.21701506.22078877.24550280.28169360.29144123.30126976.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005886	plasma membrane	15182672.28169360.	IDA	Component
GO:0005886	plasma membrane	16611247.	IDA	Component
GO:0005911	cell-cell junction	21873635.	IBA	Component
GO:0005911	cell-cell junction	15649318.	IDA	Component
GO:0005913	cell-cell adherens junction	21873635.	IBA	Component
GO:0005913	cell-cell adherens junction	16965391.	IDA	Component
GO:0008283	cell proliferation	16965391.	IDA	Process
GO:0008328	ionotropic glutamate receptor complex	21873635.	IBA	Component
GO:0014069	postsynaptic density	21873635.	IBA	Component
GO:0016080	synaptic vesicle targeting	-	IEA	Process
GO:0016323	basolateral plasma membrane	21873635.	IBA	Component
GO:0016477	cell migration	18716323.	IMP	Process
GO:0021747	cochlear nucleus development	-	IEA	Process
GO:0030027	lamellipodium	-	IEA	Component
GO:0030054	cell junction	21873635.	IBA	Component
GO:0030054	cell junction	-	IDA	Component
GO:0031252	cell leading edge	18716323.	IDA	Component
GO:0034750	Scrib-APC-beta-catenin complex	16611247.	IDA	Component
GO:0035089	establishment of apical/basal cell polarity	19041750.	IMP	Process
GO:0035255	ionotropic glutamate receptor binding	21873635.	IBA	Function
GO:0035748	myelin sheath abaxonal region	-	IEA	Component
GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	-	IEA	Process
GO:0039563	suppression by virus of host STAT1 activity	-	IEA	Process
GO:0039564	suppression by virus of host STAT2 activity	-	IEA	Process
GO:0042060	wound healing	-	IEA	Process
GO:0042734	presynaptic membrane	15182672.	IDA	Component
GO:0043065	positive regulation of apoptotic process	19041750.	IMP	Process
GO:0043113	receptor clustering	21873635.	IBA	Process
GO:0043615	astrocyte cell migration	-	IEA	Process
GO:0044291	cell-cell contact zone	-	IEA	Component
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	21873635.	IBA	Process
GO:0045202	synapse	21873635.	IBA	Component
GO:0045211	postsynaptic membrane	21873635.	IBA	Component
GO:0045211	postsynaptic membrane	15182672.	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045930	negative regulation of mitotic cell cycle	16965391.	IDA	Process
GO:0048488	synaptic vesicle endocytosis	-	IEA	Process
GO:0050918	positive chemotaxis	18716323.	IMP	Process
GO:0060088	auditory receptor cell stereocilium organization	-	IEA	Process
GO:0060561	apoptotic process involved in morphogenesis	19041750.	IMP	Process
GO:0060603	mammary gland duct morphogenesis	-	ISS	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071896	protein localization to adherens junction	16611247.	IMP	Process
GO:0090630	activation of GTPase activity	19041750.	IMP	Process
GO:0097120	receptor localization to synapse	21873635.	IBA	Process
GO:0098609	cell-cell adhesion	21873635.	IBA	Process
GO:0098609	cell-cell adhesion	16344308.	IGI	Process
GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	21873635.	IBA	Process
GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome	21873635.	IBA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099147	extrinsic component of postsynaptic density membrane	-	IEA	Component
GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.