EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22797819Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer.Tumour Biol2012 DecJeong SHdoi: 10.1007/s13277-012-0449-5
26722435Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.Int J Clin Exp Pathol2015 Oct 1Yang Y-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1070209277Missense_MutationnovelD218V0.38
BLCAchr1070218780Missense_MutationNAS54C0.44
BRCAchr1070218782Missense_MutationNAW53C0.18
BRCAchr1070233320Missense_MutationnovelG3D0.17
BRCAchr1070209638Missense_Mutationrs766193453V187M0.06
BRCAchr1070209647Missense_MutationNAE184K0.12
BRCAchr1070217874Missense_Mutationrs777717226R79C0.14
CESCchr1070217908SilentnovelN67N0.11
CHOLchr1070218794SilentnovelE49E0.16
COADchr10702333735'UTRnovel0.2
COADchr1070217863Silentrs549996621A82A0.41
COADchr1070213562Missense_Mutationrs146821187V138M0.33
COADchr1070209229Missense_MutationNAK234R0.23
GBMchr1070209590Missense_MutationnovelE203K0.22
HNSCchr1070214580Nonsense_MutationnovelE102*0.18
KIRCchr10702030333'UTRnovel0.43
KIRPchr1070214531Missense_MutationnovelD118G0.23
LIHCchr10702030643'UTRnovel0.25
LUADchr1070206325Missense_MutationnovelT245I0.41
LUSCchr1070214512SilentNAE124E0.31
LUSCchr1070209573SilentNAA208A0.45
LUSCchr1070209663SilentnovelL178L0.25
MESOchr1070209233Missense_MutationnovelK233E0.36
OVchr10702031163'UTRrs2007240780.07
OVchr1070213539SilentnovelA145A0.23
SARCchr10702333745'UTRnovel0.11
SKCMchr1070213525Missense_MutationnovelG150E0.46
SKCMchr1070213526Missense_MutationnovelG150R0.45
SKCMchr1070230358Missense_MutationNAP36S0.94
STADchr1070217811Splice_SitenovelX99_splice0.11
STADchr1070217823Missense_MutationNAA96T0.15
STADchr1070209266Frame_Shift_DelnovelS222Afs*90.1
UCECchr10702031463'UTRnovel0.28
UCECchr1070217863Silentrs549996621A82A0.49
UCECchr1070209610Missense_MutationnovelP196L0.42
UCECchr10702029813'UTRnovel0.44
UCECchr1070209623Missense_MutationNAR192W0.5
UCECchr1070213563Silentrs748397137G137G0.4
UCECchr10702030873'UTRnovel0.33
UCECchr1070213474Missense_MutationnovelA167V0.29
UCECchr1070213563Silentrs748397137G137G0.27
UCECchr10702031483'UTRnovel0.39
UCECchr1070209583Missense_MutationNAA205V0.22
UCECchr1070213493Missense_Mutationrs141014375V161M0.41
UCECchr1070214574Missense_MutationnovelP104S0.16
UCECchr1070217874Missense_Mutationrs777717226R79C0.44
UCECchr1070213591Splice_SitenovelX129_splice0.34
UCECchr1070209658Missense_MutationNAP180H0.15
UCECchr1070213541Missense_MutationNAA145T0.27
UCECchr1070209555Splice_Regionnovel0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
THCADEL0.0220.011063

Survival Analysis
CancerP-value Q-value
MESO0.028

Kaplan-Meier Survival Analysis

ACC0.0033

Kaplan-Meier Survival Analysis

SKCM0.00011

Kaplan-Meier Survival Analysis

ESCA0.02

Kaplan-Meier Survival Analysis

COAD0.015

Kaplan-Meier Survival Analysis

PAAD0.011

Kaplan-Meier Survival Analysis

PCPG0.023

Kaplan-Meier Survival Analysis

LAML0.00094

Kaplan-Meier Survival Analysis

LIHC0.017

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000180817 (Gene tree)
Gene ID
5464
Gene Symbol
PPA1
Alias
SID6-8061|Ppase|IOPPP|PP1|PP
Full Name
pyrophosphatase (inorganic) 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
31,082 bases
Position
chr10:70,202,830-70,233,911
Accession
9226
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22750791Wide range of interacting partners of pea Gβ subunit of G-proteins suggests its multiple functions in cell signalling.Plant Physiol Biochem2012 SepBhardwaj Ddoi: 10.1016/j.plaphy.2012.06.005
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000373232PPA1-2021295-ENSP00000362329289 (aa)-Q15181
ENST00000373230PPA1-201787-ENSP00000362327178 (aa)-Q5SQT6
ENST00000610026PPA1-2053524--- (aa)--
ENST00000625364PPA1-206644-ENSP00000486162178 (aa)-Q5SQT6
ENST00000495346PPA1-204282--- (aa)--
ENST00000460755PPA1-203412--- (aa)--
Gene Model
Click here to download ENSG00000180817's gene model file
Pathways
Pathway IDPathway NameSource
hsa00190Oxidative phosphorylationKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000180817Tumor Necrosis Factor-alpha8.98173037631952E-917903293
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180817's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000180817PPA19755.172YBR011CIPP19752.982Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000287magnesium ion binding-IEAFunction
GO:0004427inorganic diphosphatase activity21873635.IBAFunction
GO:0005737cytoplasm16130169.TASComponent
GO:0005829cytosol-TASComponent
GO:0006418tRNA aminoacylation for protein translation-TASProcess
GO:0006796phosphate-containing compound metabolic process21873635.IBAProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071344diphosphate metabolic process-TASProcess
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