EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26823742Methylation-silencing RCC1 expression is associated with tumorigenesis and depth of invasion in gastric cancer.Int J Clin Exp Pathol2015 Nov 1Lin YL-
29363114Exome sequencing and case-control analyses identify RCC1 as a candidate breast cancer susceptibility gene.Int J Cancer2018 Jun 15Riahi Adoi: 10.1002/ijc.31273

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr128536889SilentNAV360V0.05
BLCAchr128530546Intronnovel0.36
BRCAchr128532207Nonsense_MutationNAG100*0.15
BRCAchr128535139Frame_Shift_DelnovelA178Lfs*120.14
BRCAchr1285380803'UTRnovel0.21
CESCchr128536007Silentrs748559047L266L0.23
CESCchr128535280SilentNAL187L0.43
CHOLchr1285168275'Flanknovel0.38
COADchr128532233SilentnovelS108S0.16
COADchr128529898Frame_Shift_DelNAP13Qfs*110.49
COADchr128535369Missense_Mutationrs528320406R217Q0.38
COADchr128529898Frame_Shift_DelNAP13Qfs*110.4
COADchr128536767Missense_MutationNAR320W0.47
COADchr128536847SilentnovelA346A0.09
COADchr128531858SilentNAG43G0.33
COADchr1285381863'UTRnovel0.5
COADchr128537834Missense_Mutationrs760969624R365C0.42
COADchr128530547Intronnovel0.34
ESCAchr128537937Missense_MutationnovelR399H0.09
GBMchr128535995Silentrs138664851Y262Y0.07
GBMchr128535118Frame_Shift_DelnovelD171Cfs*190.73
GBMchr128536790SilentnovelG327G0.17
GBMchr128535959SilentnovelY250Y0.12
GBMchr128531867Frame_Shift_DelnovelQ47Sfs*80.27
GBMchr128535123Missense_MutationnovelV172E0.21
HNSCchr128532349Missense_Mutationrs751946002R147Q0.25
HNSCchr128535902SilentnovelL231L0.09
HNSCchr128531804Splice_RegionnovelV25V0.23
HNSCchr128537949Missense_MutationnovelS403Y0.19
HNSCchr128535122Missense_Mutationrs773841273V172M0.3
KIRCchr128531848Missense_MutationnovelL40Q0.16
LIHCchr128535369Missense_MutationNAR217P0.34
LIHCchr128537993Missense_MutationNAK418E0.36
LIHCchr128536806Missense_Mutationrs547058163E333K0.55
LIHCchr128536747Missense_MutationnovelG313E0.38
LUADchr128535332Missense_MutationNAG205C0.28
LUADchr128535331SilentnovelL204L0.2
LUADchr128531876SilentNAG49G0.4
LUADchr128537917Missense_MutationnovelM392I0.5
LUADchr128536856SilentNAS349S0.16
LUADchr128535921Missense_MutationnovelG238C0.12
LUSCchr128531976In_Frame_DelnovelS83del0.24
LUSCchr128530530Intronnovel0.18
LUSCchr128535133SilentnovelV175V0.66
OVchr128535933Nonsense_MutationnovelF242*0.05
OVchr128536776Missense_MutationNAY323D0.15
OVchr128537871Missense_MutationnovelL377P0.15
PAADchr128530580Intronnovel0.1
PAADchr128536782Missense_MutationnovelR325W0.19
PRADchr128531858SilentNAG43G0.33
READchr128535087Missense_MutationnovelK160R0.6
READchr128536376Missense_Mutationrs745611564S311L0.24
READchr1285380143'UTRnovel0.23
SARCchr128531967Missense_MutationnovelV80L0.4
SKCMchr128537844Missense_MutationnovelA368V0.4
SKCMchr128532309Missense_MutationNAL134F0.22
SKCMchr128537863SilentnovelN374N0.48
SKCMchr128535141Missense_MutationnovelA178V0.24
SKCMchr128535142SilentnovelA178A0.25
SKCMchr128537834Missense_Mutationrs760969624R365C0.44
SKCMchr128535334SilentNAG205G0.43
SKCMchr128532179SilentNAS90S0.26
SKCMchr128530586Intronnovel0.27
SKCMchr128532178Missense_MutationNAS90F0.71
SKCMchr128535359Missense_MutationNAR214G0.23
SKCMchr128531966Silentrs753253859T79T0.54
STADchr128536376Missense_Mutationrs745611564S311L0.3
STADchr128536805SilentnovelA332A0.07
STADchr128537965SilentNAG408G0.41
STADchr128535374Missense_MutationnovelG219R0.16
STADchr128530552Intronnovel0.36
STADchr128531832Missense_MutationNAG35S0.36
STADchr128529881SilentNAR5R0.21
STADchr128529897Frame_Shift_Insrs779694464A14Sfs*390.4
STADchr128532232Missense_Mutationrs150426843S108L0.41
STADchr128535874Missense_MutationNAR222Q0.27
STADchr128531917Missense_MutationnovelV63A0.29
STADchr128535986SilentNAG259G0.14
TGCTchr128530585Intronnovel0.21
THCAchr128536773Missense_MutationNAE322K0.21
UCECchr128535910Frame_Shift_DelnovelG235Efs*60.16
UCECchr1285380273'UTRnovel0.07
UCECchr128532231Missense_MutationNAS108T0.26
UCECchr128535977SilentNAS256S0.21
UCECchr128536761SilentNAL318L0.2
UCECchr128537927Silentrs372931907L396L0.31
UCECchr128536022Missense_MutationNAQ271H0.54
UCECchr128531908Missense_MutationnovelP60L0.42
UCECchr128530608Intronnovel0.44
UCECchr128536766SilentnovelG319G0.27
UCECchr1285380883'UTRnovel0.15
UCECchr128530590Intronnovel0.21
UCECchr128536018Missense_Mutationrs764461802H270R0.52
UCECchr128532173Splice_RegionnovelV88V0.56
UCECchr128536376Missense_Mutationrs745611564S311L0.25
UCECchr128530558Intronrs7794658680.28
UCECchr128535360Missense_Mutationrs763928410R214H0.35
UCECchr128532271Missense_MutationnovelV121A0.33
UCECchr128535965SilentnovelT252T0.32
UCECchr128537959Silentrs779103379S406S0.47
UCECchr128529898Frame_Shift_DelNAP13Qfs*110.31
UCECchr128535917SilentnovelS236S0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.77783.3987e-23
DLBCDEL0.10420.011841
ESCADEL0.28260.0012162
KIRCDEL0.14582.3538e-09
KIRPDEL0.17011.462e-09
LIHCDEL0.35141.6679e-20
LUADDEL0.1570.0024765
LUSCDEL0.34332.5882e-07
MESODEL0.22992.434e-07
READDEL0.42.1758e-10
TGCTDEL0.15330.00046313

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.0058

Kaplan-Meier Survival Analysis

SARC0.00011

Kaplan-Meier Survival Analysis

MESO0.025

Kaplan-Meier Survival Analysis

ACC0.0046

Kaplan-Meier Survival Analysis

SKCM0.00054

Kaplan-Meier Survival Analysis

PRAD0.036

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

PAAD0.0029

Kaplan-Meier Survival Analysis

READ0.019

Kaplan-Meier Survival Analysis

LAML0.027

Kaplan-Meier Survival Analysis

LIHC0.00019

Kaplan-Meier Survival Analysis

LGG0.00012

Kaplan-Meier Survival Analysis

LUAD0.0071

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000180198 (Gene tree)
Gene ID
1104
Gene Symbol
RCC1
Alias
CHC1
Full Name
regulator of chromosome condensation 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
33,358 bases
Position
chr1:28,505,943-28,539,300
Accession
1913
RBP type
non-canonical RBP
Summary
(Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Diseases associated with RCC1 include Raynaud Disease and Microcystic Meningioma. Among its related pathways are DNA Damage and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include chromatin binding and nucleosomal DNA binding. An important paralog of this gene is RPGR.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24961801Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos.Development2014 JulSpiro Zdoi: 10.1242/dev.107508.
27145786Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.Chromosome Res2016 SepEastland Adoi: 10.1007/s10577-016-9528-6
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000398958RCC1-2042715-ENSP00000381931421 (aa)-P18754
ENST00000411533RCC1-2051169-ENSP00000413644372 (aa)-C9JW69
ENST00000486790RCC1-212481-ENSP00000472057148 (aa)-M0R1Q8
ENST00000373831RCC1-2011577-ENSP00000362937452 (aa)-P18754
ENST00000430407RCC1-2091121-ENSP00000394650283 (aa)-C9JQZ4
ENST00000419074RCC1-206997-ENSP00000402260272 (aa)-C9JMJ4
ENST00000434290RCC1-2101070-ENSP00000405258264 (aa)-C9J3R0
ENST00000373833RCC1-2032844-ENSP00000362939421 (aa)-P18754
ENST00000427469RCC1-207903-ENSP00000402740230 (aa)-C9JRH2
ENST00000478232RCC1-211509--- (aa)--
ENST00000429051RCC1-208538--- (aa)--
ENST00000373832RCC1-2022424-ENSP00000362938421 (aa)-P18754
ENST00000649185RCC1-2132686-ENSP00000497402452 (aa)-A0A0S2Z404
Gene Model
Click here to download ENSG00000180198's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000180198Sleep2E-627126917
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000180198rs56272623128514428TNight sleep phenotypes27126917[0.45-1.08] unit increase0.7624EFO_0007827
ENSG00000180198rs6689862128510931TSystolic blood pressure30578418[0.23-0.43] mmHg decrease0.3273EFO_0006335
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180198's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle3678831.IMPProcess
GO:0000785chromatin12121620.IDAComponent
GO:0000790nuclear chromatin15014043.IDAComponent
GO:0000794condensed nuclear chromosome15014043.IDAComponent
GO:0003682chromatin binding2677018.IDAFunction
GO:0005087Ran guanyl-nucleotide exchange factor activity1944575.IDAFunction
GO:0005087Ran guanyl-nucleotide exchange factor activity11336674.IMPFunction
GO:0005087Ran guanyl-nucleotide exchange factor activity-TASFunction
GO:0005515protein binding1961752.7616957.9637251.11336674.11932251.16820410.18617507.20668449.20739938.29040603.29997244.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus17435751.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm17435751.IDAComponent
GO:0007052mitotic spindle organization15014043.IDAProcess
GO:0007059chromosome segregation17435751.IMPProcess
GO:0007088regulation of mitotic nuclear division15014043.IDAProcess
GO:0008536Ran GTPase binding11336674.IDAFunction
GO:0016032viral process-TASProcess
GO:0031491nucleosome binding20347844.IMPFunction
GO:0031492nucleosomal DNA binding17435751.IDAFunction
GO:0031965nuclear membrane-IDAComponent
GO:0032991protein-containing complex11336674.IDAComponent
GO:0042393histone binding11375490.IDAFunction
GO:0043199sulfate binding11336674.IDAFunction
GO:0046982protein heterodimerization activity11336674.IPIFunction
GO:0051225spindle assembly17435751.IMPProcess
GO:0051290protein heterotetramerization11336674.IDAProcess
GO:0051301cell division-IEAProcess
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