EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20179993Newly identified tumor-associated role of human Sharpin.Mol Cell Biochem2010 JulJung Jdoi: 10.1007/s11010-010-0413-x
28230260Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals.Prostate2017 MayHuang Hdoi: 10.1002/pros.23302
25992689Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk.PLoS One2015 May 19De Melo Jdoi: 10.1371/journal.pone.0127546
26506596A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker.Oncotarget2015 Nov 24Bii VMdoi: 10.18632/oncotarget.6232.
28063307SHARPIN Facilitates p53 Degradation in Breast Cancer Cells.Neoplasia2017 FebYang Hdoi: 10.1016/j.neo.2016.12.002
29248549A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer.Biochim Biophys Acta Mol Basis Dis2018 MarOjo Ddoi: 10.1016/j.bbadis.2017.12.018

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr8144099800Missense_Mutationrs777839426E188K0.22
BLCAchr8144098953SilentnovelP363P0.43
BLCAchr8144099188Nonsense_Mutationrs201083501Q314*0.39
BRCAchr8144099705Missense_MutationnovelI219M0.18
BRCAchr8144099386SilentNAV271V0.13
BRCAchr8144099293SilentNAA302A0.26
BRCAchr8144099761Frame_Shift_DelnovelQ193Sfs*250.2
BRCAchr8144100062Missense_MutationNAK128N0.16
CESCchr8144099831SilentnovelG177G0.18
CESCchr8144098981Missense_MutationNAC354Y0.13
CESCchr8144103179Missense_MutationNAG83D0.23zf-RanBP
COADchr8144103048Splice_Regionnovel0.36
COADchr8144099758Missense_Mutationrs776988893R202C0.33
COADchr8144099142Frame_Shift_DelnovelP329Hfs*830.11
COADchr8144103144Missense_MutationnovelG95W0.12
ESCAchr8144099361Missense_MutationnovelE280Q0.1
GBMchr8144098915Missense_MutationnovelP376R0.25
GBMchr8144099416Silentrs200626709L261L0.2
GBMchr8144103163Missense_MutationnovelE88D0.2
GBMchr8144099709Missense_MutationnovelP218H0.09
HNSCchr8144099425SilentnovelF258F0.24
HNSCchr8144099126SilentnovelP334P0.07
LAMLchr81440988743'UTRnovel0.14
LGGchr8144098914SilentnovelP376P0.38
LGGchr8144099168Silentrs555935290D320D0.33
LUADchr8144098962SilentnovelI360I0.26
LUADchr8144099423Missense_Mutationrs762859512S259L0.37
LUSCchr8144099154Missense_Mutationrs61732529R325H0.14
LUSCchr8144103182Frame_Shift_DelnovelG83Pfs*760.69zf-RanBP
LUSCchr8144099421Nonsense_MutationnovelE260*0.14
OVchr8144098956SilentNAA362A0.21
OVchr8144098987Nonsense_MutationNAW352*0.23
PAADchr8144099798Missense_MutationnovelE188D0.09
PRADchr8144099386SilentNAV271V0.22
SARCchr8144100036Missense_MutationnovelP137L0.72
SARCchr8144099573Silentrs778021240A235A0.11
SKCMchr81440987473'UTRnovel1
SKCMchr8144098928Missense_MutationNAS372C0.16
STADchr8144103087Missense_MutationnovelV114F0.12
STADchr8144098990Missense_MutationNAS351N0.1
UCECchr8144099591SilentnovelA229A0.08
UCECchr8144099599Missense_MutationnovelD227Y0.55
UCECchr8144099167Missense_Mutationrs200344062G321R0.29
UCECchr8144098925Missense_MutationNAT373P0.28
UCECchr8144099301SilentnovelL300L0.31
UCECchr8144099374SilentNAC275C0.32
UCECchr8144099573Silentrs778021240A235A0.23
UCECchr8144099408Missense_Mutationrs375767993P264L0.34
UCECchr8144099142Frame_Shift_DelnovelP329Hfs*830.24
UCECchr8144099301Missense_MutationnovelL300M0.21
UCECchr8144103050Splice_SiteNAX126_splice0.25
UCECchr8144099142Frame_Shift_DelnovelP329Hfs*830.56
UCECchr8144103079Silentrs746401527V116V0.47

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.250.018626
KIRCAMP0.11740.15559
LGGDEL0.04680.014004
SARCAMP0.25290.18425
SKCMAMP0.45232.8957e-05
TGCTAMP0.560.13696
UVMAMP0.73758.8879e-13

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

UCS0.03

Kaplan-Meier Survival Analysis

COAD0.033

Kaplan-Meier Survival Analysis

READ0.032

Kaplan-Meier Survival Analysis

LAML0.0056

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LIHC0.0054

Kaplan-Meier Survival Analysis

CHOL0.02

Kaplan-Meier Survival Analysis

UVM0.014

Kaplan-Meier Survival Analysis

OV0.01

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000179526 (Gene tree)
Gene ID
81858
Gene Symbol
SHARPIN
Alias
DKFZP434N1923|SIPL1
Full Name
SHANK associated RH domain interactor
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
9,492 bases
Position
chr8:144,098,633-144,108,124
Accession
25321
RBP type
canonical RBP
Summary
SHARPIN (SHANK Associated RH Domain Interactor) is a Protein Coding gene. Diseases associated with SHARPIN include Incontinentia Pigmenti and Branchiootic Syndrome. Among its related pathways are TNF signaling (REACTOME) and Protein-protein interactions at synapses. Gene Ontology (GO) annotations related to this gene include identical protein binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is RBCK1.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000432355zf-RanBPPF00641.182.1e-0611
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000533184SHARPIN-207352--- (aa)--
ENST00000532536SHARPIN-206533-ENSP0000043235595 (aa)-H0YCU2
ENST00000534435SHARPIN-210656--- (aa)--
ENST00000530216SHARPIN-204673--- (aa)--
ENST00000531375SHARPIN-205613--- (aa)--
ENST00000359551SHARPIN-2011687-ENSP00000352551326 (aa)-Q9H0F6
ENST00000398712SHARPIN-2021765XM_017013887ENSP00000381698387 (aa)XP_016869376Q9H0F6
ENST00000534242SHARPIN-209933--- (aa)--
ENST00000533948SHARPIN-208981--- (aa)--
ENST00000525275SHARPIN-203521--- (aa)--
Gene Model
Click here to download ENSG00000179526's gene model file
Pathways
Pathway IDPathway NameSource
hsa04217NecroptosisKEGG
hsa04621NOD-like receptor signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000179526Metabolism6E-11024816252
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000179526rs125507298144100505TBlood metabolite levels24816252[0.058-0.07] unit increase0.064EFO_0005664
ENSG00000179526rs341730628144103704ANeutrophil percentage of granulocytes27863252[0.044-0.073] unit decrease0.05862283EFO_0007994
ENSG00000179526rs341730628144103704AEosinophil percentage of granulocytes27863252[0.046-0.074] unit increase0.0599948EFO_0007996
ENSG00000179526rs341730628144103704ASum eosinophil basophil counts27863252[0.043-0.072] unit increase0.05751766EFO_0005090|EFO_0004842
ENSG00000179526rs341730628144103704AEosinophil percentage of white cells27863252[0.045-0.074] unit increase0.05961465EFO_0007991
ENSG00000179526rs341730628144103704AEosinophil counts27863252[0.045-0.074] unit increase0.05925318EFO_0004842
ENSG00000179526rs341730628144103704?Respiratory diseases30595370EFO_0000684
ENSG00000179526rs341730628144103704?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179526's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000179526SHARPIN10085.263ENSAMEG00000006042SHARPIN9582.173Ailuropoda_melanoleuca
ENSG00000179526SHARPIN8838.931ENSACAG00000007245-5440.000Anolis_carolinensis
ENSG00000179526SHARPIN10080.000ENSCAFG00000001536SHARPIN9576.880Canis_familiaris
ENSG00000179526SHARPIN10089.474ENSCCAG00000036190SHARPIN9391.643Cebus_capucinus
ENSG00000179526SHARPIN9766.304ENSDORG00000008469Sharpin9971.386Dipodomys_ordii
ENSG00000179526SHARPIN10085.263ENSECAG00000001400SHARPIN8883.242Equus_caballus
ENSG00000179526SHARPIN10085.263ENSECAG00000002550-8682.967Equus_caballus
ENSG00000179526SHARPIN10085.263ENSFCAG00000011548SHARPIN9382.173Felis_catus
ENSG00000179526SHARPIN9239.348ENSGALG00000048524SHARPIN7538.667Gallus_gallus
ENSG00000179526SHARPIN10097.895ENSGGOG00000027471SHARPIN9797.508Gorilla_gorilla
ENSG00000179526SHARPIN9172.093MGP_CAROLIEiJ_G0019922Sharpin10072.093Mus_caroli
ENSG00000179526SHARPIN9173.256ENSMUSG00000022552Sharpin9973.256Mus_musculus
ENSG00000179526SHARPIN9170.930MGP_PahariEiJ_G0019932Sharpin10070.930Mus_pahari
ENSG00000179526SHARPIN9173.256MGP_SPRETEiJ_G0020825Sharpin10073.256Mus_spretus
ENSG00000179526SHARPIN10085.263ENSPPRG00000015953SHARPIN9381.337Panthera_pardus
ENSG00000179526SHARPIN10085.263ENSPTIG00000016864SHARPIN8379.439Panthera_tigris_altaica
ENSG00000179526SHARPIN5843.333ENSSPUG00000017933SHARPIN7342.222Sphenodon_punctatus
ENSG00000179526SHARPIN10077.895ENSSSCG00000005914SHARPIN8777.716Sus_scrofa
ENSG00000179526SHARPIN9985.106ENSUMAG00000020808SHARPIN7179.608Ursus_maritimus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004842ubiquitin-protein transferase activity21873635.IBAFunction
GO:0005515protein binding21455173.21455180.21455181.21709223.21947080.22158122.23032186.23104095.24141947.27070702.IPIFunction
GO:0005829cytosol20179993.IDAComponent
GO:0005829cytosol-TASComponent
GO:0007005mitochondrion organization-IEAProcess
GO:0007249I-kappaB kinase/NF-kappaB signaling-TASProcess
GO:0007420brain development-IEAProcess
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway21455173.IDAProcess
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TASProcess
GO:0014069postsynaptic density-IEAComponent
GO:0030054cell junction-IEAComponent
GO:0030262apoptotic nuclear changes-IEAProcess
GO:0030425dendrite-IEAComponent
GO:0031424keratinization-IEAProcess
GO:0031593polyubiquitin modification-dependent protein binding21455173.21455181.IDAFunction
GO:0042802identical protein binding-IEAFunction
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling21873635.IBAProcess
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling21455173.IDAProcess
GO:0043130ubiquitin binding21873635.IBAFunction
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process21873635.IBAProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0046872metal ion binding-IEAFunction
GO:0050728negative regulation of inflammatory response-ISSProcess
GO:0051260protein homooligomerization-IEAProcess
GO:0071797LUBAC complex21873635.IBAComponent
GO:0071797LUBAC complex21455173.21455180.21455181.24726323.27523608.IDAComponent
GO:0097039protein linear polyubiquitination21873635.IBAProcess
GO:0097039protein linear polyubiquitination21455173.21455180.21455181.IDAProcess
GO:2000348regulation of CD40 signaling pathway21455173.IDAProcess
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