EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19597826Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis.Int J Colorectal Dis2009 NovHe Ydoi: 10.1007/s00384-009-0759-2
24659377Enhanced expression of IMPDH2 promotes metastasis and advanced tumor progression in patients with prostate cancer.Clin Transl Oncol2014 OctZhou Ldoi: 10.1007/s12094-014-1167-9
25465060Elevated expression of IMPDH2 is associated with progression of kidney and bladder cancer.Med Oncol2015 JanZou Jdoi: 10.1007/s12032-014-0373-1

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr349027790Missense_MutationnovelG151R0.29
BLCAchr349026365Missense_Mutationrs754546292R322Q0.1
BLCAchr349025154Silentrs183457824A374A0.55
BLCAchr349026881SilentnovelL209L0.13
BLCAchr349026338Missense_MutationnovelC331S0.5
BLCAchr349024973Missense_MutationnovelI406M0.46
BLCAchr349024547Missense_MutationnovelE491Q0.33
BLCAchr349026978Missense_MutationnovelL201V0.06
BLCAchr349026834SilentnovelR224R0.24
BLCAchr349024801Missense_MutationnovelE433K0.43
BLCAchr349025028Missense_MutationNAS388C0.14
BRCAchr349024908Missense_MutationNAN428S0.44
BRCAchr349029312SilentNAV13V0.19
BRCAchr3490243483'UTRnovel0.14
BRCAchr349027743SilentNAL166L0.4
CESCchr349024971Missense_MutationnovelR407Q0.3
CESCchr349026971Missense_Mutationrs761002300R203H0.4
CESCchr349024534Missense_MutationNAS495F0.23
COADchr349028493Missense_MutationNAT63A0.17
COADchr349024955SilentNAR412R0.13
COADchr349028487SilentNAL65L0.35
COADchr349027821Silentrs530770243C140C0.28
COADchr349025215Missense_MutationnovelA354V0.42
COADchr349026521Missense_MutationNAN303I0.4
COADchr349026972Missense_Mutationrs769004042R203C0.14
COADchr349028492Missense_MutationNAT63I0.46
COADchr349026836Missense_Mutationrs377463111R224W0.09
ESCAchr349027890Missense_MutationnovelD117E0.09
GBMchr349024788Missense_MutationnovelI437T0.13
GBMchr349029288SilentNAQ21Q0.46
GBMchr349028758Splice_RegionnovelV49V0.1
GBMchr3490243793'UTRnovel0.67
GBMchr349028509Missense_MutationnovelK57N0.07
GBMchr349027036Missense_MutationnovelK181N0.14
GBMchr349024720SilentNAL460L0.08
GBMchr3490243543'UTRnovel0.32
GBMchr349028699Intronnovel0.22
GBMchr349026843SilentNAI221I0.74
HNSCchr349026561In_Frame_DelnovelK288_Y289del0.82
HNSCchr349026774SilentnovelL244L0.74
HNSCchr3490243743'UTRnovel0.1
HNSCchr349024516Missense_MutationnovelG501A0.14
HNSCchr349026843Missense_MutationnovelI221M0.08
KIRPchr349027044Missense_MutationnovelM179V0.23
LGGchr349027823Missense_MutationNAC140S0.25
LUADchr349024957Missense_MutationnovelR412S0.08
LUADchr349025127Splice_RegionnovelT383T0.21
LUADchr349027765Missense_MutationnovelS159F0.16
LUSCchr349026984Missense_MutationnovelE199K0.2
LUSCchr349026866Nonsense_MutationnovelE214*0.17
LUSCchr349027736Missense_Mutationrs779639948E169K0.48
OVchr349024685SilentnovelI471I0.05
OVchr3490243723'UTRnovel0.31
OVchr349024799In_Frame_InsnovelA434_D435insHLIRA0.06
OVchr349026732SilentNAY258Y0.27
PAADchr349025212Missense_MutationnovelR355Q0.26
PAADchr349027835Missense_MutationnovelR136W0.2
PRADchr349028315Missense_MutationnovelG86D0.15
PRADchr349024957Missense_Mutationrs779322486R412C0.27
READchr349028489Frame_Shift_DelNAP64Hfs*170.28
READchr349024944Missense_MutationNAS416Y0.17
READchr349027036Missense_MutationnovelK181N0.44
READchr349028475Missense_MutationnovelP69S0.33
SARCchr349026586Missense_MutationnovelI281M0.53
SKCMchr349028503SilentNAI59I0.11
SKCMchr349027725SilentNAD172D0.52
SKCMchr349028790Missense_MutationnovelP39S0.33
SKCMchr349029263Missense_MutationNAL30F0.22
SKCMchr349027719SilentNAF174F0.33
SKCMchr349024406Splice_SitenovelX508_splice0.41
SKCMchr349028275SilentnovelF99F0.16
STADchr349025155Missense_MutationnovelA374V0.14
STADchr349028712Intronnovel0.45
STADchr349024802Splice_RegionNAS432S0.04
STADchr349028294Missense_MutationNAH93R0.19
STADchr349028463Frame_Shift_InsnovelV73Qfs*90.23
STADchr349026332Missense_MutationNAT333M0.13
STADchr349026332Missense_MutationNAT333M0.3
STADchr349026994Missense_MutationNAK195N0.05
STADchr349026815Missense_MutationNAR231W0.29
THCAchr349026590Missense_MutationNAS280C0.07
THCAchr349025213Missense_MutationNAR355W0.1
UCECchr349028485SilentNAL65L0.22
UCECchr349024537Missense_Mutationrs757423578T494M0.35
UCECchr349024495Missense_Mutationrs750101189S508L0.19
UCECchr349027733Nonsense_MutationNAE170*0.37
UCECchr349025211SilentNAR355R0.43
UCECchr349026853Missense_MutationnovelL218P0.29
UCECchr349026341Missense_MutationNAI330T0.41
UCECchr349027862Missense_MutationNAV127M0.11
UCECchr349028314SilentNAG86G0.22
UCECchr349029288SilentNAQ21Q0.17
UCECchr349024512Silentrs374837017G502G0.44
UCECchr349026696Silentrs771750284V270V0.34
UCECchr349024935Missense_MutationnovelA419V0.13
UCECchr349026835Missense_Mutationrs373752085R224Q0.45
UCECchr349024908Missense_MutationNAN428S0.38
UCECchr349025181SilentnovelG365G0.37
UCECchr349029260Missense_MutationnovelT31A0.11
UCECchr349024709SilentnovelG463G0.44
UCECchr349026878Missense_MutationnovelP210S0.4
UCECchr349027915Missense_MutationnovelK109R0.23
UCECchr349029347Missense_MutationnovelA2T0.23
UCECchr349024680Missense_MutationnovelA473V0.4
UCECchr349026796Missense_MutationnovelS237F0.18
UCECchr349028270Missense_MutationnovelA101D0.26
UCECchr349024494Splice_Siters748863433X508_splice0.17
UCECchr349025253SilentnovelR341R0.07
UCECchr349025154Silentrs183457824A374A0.46
UCECchr349027764SilentnovelS159S0.19
UCECchr349028522Missense_MutationnovelS53Y0.24
UCECchr349028719Intronnovel0.13
UCECchr349026984Nonsense_MutationnovelE199*0.33
UCECchr349026847Missense_MutationnovelA220V0.42
UCECchr349029301Missense_MutationNAG17E0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.27694.5968e-31
CHOLDEL0.80560.02241
DLBCDEL0.16670.016959
GBMDEL0.07450.056565
LGGDEL0.0780.00089193
LUADDEL0.3430.0021265
PAADDEL0.18480.030662
SARCDEL0.2140.0034746
SKCMDEL0.16350.13887
TGCTAMP0.120.23596
TGCTDEL0.19330.08422
THYMDEL0.08130.037527

Survival Analysis
CancerP-value Q-value
SARC0.0035

Kaplan-Meier Survival Analysis

ACC0.038

Kaplan-Meier Survival Analysis

SKCM0.0023

Kaplan-Meier Survival Analysis

BRCA0.022

Kaplan-Meier Survival Analysis

KICH0.012

Kaplan-Meier Survival Analysis

GBM0.011

Kaplan-Meier Survival Analysis

LIHC0.00076

Kaplan-Meier Survival Analysis

DLBC0.016

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

UVM0.00063

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000178035 (Gene tree)
Gene ID
3615
Gene Symbol
IMPDH2
Alias
N
Full Name
inosine monophosphate dehydrogenase 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
5,377 bases
Position
chr3:49,024,325-49,029,701
Accession
6053
RBP type
non-canonical RBP
Summary
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000466147IMPDH2-206691--- (aa)--
ENST00000496837IMPDH2-212760--- (aa)--
ENST00000484872IMPDH2-209643--- (aa)--
ENST00000462980IMPDH2-204908--- (aa)--
ENST00000472328IMPDH2-207469--- (aa)--
ENST00000326739IMPDH2-2011643XM_006713128ENSP00000321584514 (aa)XP_006713191P12268
ENST00000481274IMPDH2-208840--- (aa)--
ENST00000442157IMPDH2-203865-ENSP00000403502279 (aa)-E7ETK5
ENST00000463903IMPDH2-205420--- (aa)--
ENST00000491610IMPDH2-211844--- (aa)--
ENST00000429182IMPDH2-2021469-ENSP00000393525470 (aa)-H0Y4R1
ENST00000485500IMPDH2-210852--- (aa)--
Gene Model
Click here to download ENSG00000178035's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa00983Drug metabolism - other enzymesKEGG
hsa01100Metabolic pathwaysKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000178035rs72624911349027143TEducational attainment (years of education)30038396[0.022-0.035] unit increase0.0282EFO_0004784
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178035's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000166nucleotide binding14766016.IDAFunction
GO:0003677DNA binding-IEAFunction
GO:0003723RNA binding-IEAFunction
GO:0003938IMP dehydrogenase activity21873635.IBAFunction
GO:0005515protein binding25416956.28985504.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus14766016.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm14766016.IDAComponent
GO:0005778peroxisomal membrane21525035.HDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006177GMP biosynthetic process-IEAProcess
GO:0006183GTP biosynthetic process21873635.IBAProcess
GO:0007623circadian rhythm28985504.IDAProcess
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0034774secretory granule lumen-TASComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0046651lymphocyte proliferation-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0051289protein homotetramerization-IEAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0060041retina development in camera-type eye-IEAProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071353cellular response to interleukin-4-IEAProcess
GO:1904813ficolin-1-rich granule lumen-TASComponent
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