EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20682398	Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.	Cancer Genet Cytogenet	2010 Sep	Pehlivan S	doi: 10.1016/j.cancergencyto.2010.05.019.
25934696	HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis.	Mol Cancer Res	2015 Jul	Janeckova L	doi: 10.1158/1541-7786.MCR-15-0033
27793057	Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.	Oncotarget	2016 Dec 20	Wu W	doi: 10.18632/oncotarget.12936.
27449031	HIC1 modulates uveal melanoma progression by activating lncRNA-numb.	Tumour Biol	2016 Sep	Cheng G	-
22544915	Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification.	J Clin Endocrinol Metab	2012 Jul	Svedlund J	doi: 10.1210/jc.2011-3136
16386221	[Chromosome arm 17p13.3: could HIC1 be the one ?].	Med Sci (Paris)	2006 Jan	Chopin V	-
12052894	The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.	Mol Cell Biol	2002 Jul	Deltour S	-
19525223	Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).	J Biol Chem	2009 Jul 31	Van Rechem C	doi: 10.1074/jbc.M109.022350
22136354	Alterations in promoter methylation status of tumor suppressor HIC1, SFRP2, and DAPK1 genes in prostate carcinomas.	DNA Cell Biol	2012 May	Kilinc D	doi: 10.1089/dna.2011.1431
17982487	Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma.	Oncogene	2008 Apr 17	Stocklein H	-
29367758	The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.	Oncogene	2018 Apr	Szczepny A	doi: 10.1038/s41388-017-0022-1
24489730	Small activating RNA restores the activity of the tumor suppressor HIC-1 on breast cancer.	PLoS One	2014 Jan 28	Zhao F	doi: 10.1371/journal.pone.0086486
23769968	Inactivation of tumor suppressor gene HIC1 in gastric cancer is reversed via small activating RNAs.	Gene	2013 Sep 15	Pan S	doi: 10.1016/j.gene.2013.05.034
22552606	Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer.	Ann Surg Oncol	2013 Dec	Zhao G	doi: 10.1245/s10434-012-2364-9
21533545	Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions.	Mol Cells	2011 Jul	Yu J	doi: 10.1007/s10059-011-2316-4
23340301	HIC1 modulates prostate cancer progression by epigenetic modification.	Clin Cancer Res	2013 Mar 15	Zheng J	doi: 10.1158/1078-0432.CCR-12-2888
24295734	HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2.	Cancer Res	2014 Feb 1	Cheng G	doi: 10.1158/0008-5472.CAN-13-2420
28466555	HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.	J Pathol	2017 Aug	Hao M	doi: 10.1002/path.4913
28708932	Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.	Cancer	2017 Nov 15	Okazaki S	doi: 10.1002/cncr.30880
26671036	Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer.	Ann Surg Oncol	2017 Feb	Chen HC	doi: 10.1245/s10434-015-5024-z

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr17	2058268	Silent	novel	T545T	0.19
CESC	chr17	2061229	3'Flank	NA		0.31
COAD	chr17	2058909	3'UTR	novel		0.57
COAD	chr17	2059656	3'UTR	novel		0.33
COAD	chr17	2056832	Missense_Mutation	NA	A67T	0.08
COAD	chr17	2057945	Missense_Mutation	NA	V438M	0.34
COAD	chr17	2056774	Silent	NA	C47C	0.3
COAD	chr17	2058362	Missense_Mutation	NA	R577C	0.44
COAD	chr17	2059376	3'UTR	novel		0.3
COAD	chr17	2058799	Silent	novel	P722P	0.14
COAD	chr17	2056946	Missense_Mutation	rs759366814	R105C	0.32
COAD	chr17	2058324	Missense_Mutation	novel	A564V	0.16
COAD	chr17	2059311	3'UTR	novel		0.56
COAD	chr17	2061466	3'Flank	novel		0.7
KIRC	chr17	2057836	Frame_Shift_Del	novel	*E402Rfs51**	0.63
KIRP	chr17	2061445	3'Flank	novel		0.24
LIHC	chr17	2059598	3'UTR	novel		0.3
LUAD	chr17	2058422	Missense_Mutation	NA	G597S	0.24
LUSC	chr17	2057016	Missense_Mutation	novel	A128V	0.86
MESO	chr17	2058738	Missense_Mutation	novel	G702D	0.47
PAAD	chr17	2057692	Missense_Mutation	novel	S353R	0.16
PRAD	chr17	2058473	Missense_Mutation	NA	A614T	0.22
PRAD	chr17	2058254	Missense_Mutation	NA	G541R	0.33	zf-C2H2
PRAD	chr17	2056712	Missense_Mutation	novel	P27S	0.17
READ	chr17	2058999	3'UTR	novel		0.24
SARC	chr17	2058102	Missense_Mutation	novel	G490E	0.35
SARC	chr17	2059591	3'UTR	novel		0.6
SARC	chr17	2057992	Silent	novel	N453N	0.47
SKCM	chr17	2056735	Silent	rs202126573	L34L	0.19
SKCM	chr17	2058370	Silent	NA	T579T	0.5
SKCM	chr17	2056690	Silent	NA	T19T	0.2
SKCM	chr17	2056775	Missense_Mutation	novel	D48N	0.55
STAD	chr17	2058134	Missense_Mutation	rs771684583	G501R	0.32
STAD	chr17	2058425	Missense_Mutation	NA	G598S	0.39
STAD	chr17	2057999	Missense_Mutation	rs765775523	V456M	0.32
STAD	chr17	2056964	Missense_Mutation	NA	E111K	0.23
STAD	chr17	2058487	Frame_Shift_Del	novel	*G620Pfs160**	0.33
STAD	chr17	2057811	Missense_Mutation	NA	G393D	0.4
STAD	chr17	2056702	Silent	novel	T23T	0.31
STAD	chr17	2056968	Missense_Mutation	NA	A112V	0.21
STAD	chr17	2057995	Silent	NA	A454A	0.14
STAD	chr17	2057866	Silent	rs556577424	P411P	0.19
STAD	chr17	2056334	Silent	novel	L9L	0.29
UCEC	chr17	2058066	Missense_Mutation	novel	G478V	0.25
UCEC	chr17	2059495	3'UTR	novel		0.29
UCEC	chr17	2061141	3'Flank	novel		0.5
UCEC	chr17	2058297	Missense_Mutation	novel	R555H	0.52	zf-C2H2
UCEC	chr17	2058423	Missense_Mutation	novel	G597D	0.17
UCEC	chr17	2058051	Missense_Mutation	novel	A473V	0.61
UCEC	chr17	2058286	Silent	novel	T551T	0.45
UCEC	chr17	2061476	3'Flank	rs777936944		0.35
UCEC	chr17	2058121	Silent	novel	A496A	0.36
UCEC	chr17	2058229	Silent	novel	T532T	0.39
UCEC	chr17	2059666	3'UTR	novel		0.22
UCEC	chr17	2059656	3'UTR	novel		0.27
UCEC	chr17	2061180	3'Flank	novel		0.44
UCEC	chr17	2056310	Translation_Start_Site	novel	M1?	0.3
UCEC	chr17	2061375	3'Flank	novel		0.26
UCEC	chr17	2059530	3'UTR	novel		0.33
UCEC	chr17	2059543	3'UTR	novel		0.4
UCEC	chr17	2059595	3'UTR	novel		0.53

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5297	3.9592e-10
LUAD	DEL	0.4496	0.00029194
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
STAD	0.032	Kaplan-Meier Survival Analysis
MESO	0.019	Kaplan-Meier Survival Analysis
ACC	0.0084	Kaplan-Meier Survival Analysis
HNSC	0.037	Kaplan-Meier Survival Analysis
TGCT	0.043	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
COAD	0.041	Kaplan-Meier Survival Analysis
PAAD	0.012	Kaplan-Meier Survival Analysis
UCEC	0.0069	Kaplan-Meier Survival Analysis
LGG	0.049	Kaplan-Meier Survival Analysis
THCA	0.029	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177374 (Gene tree)
Gene ID: 3090
Gene Symbol: HIC1
Alias: ZBTB29|ZNF901
Full Name: HIC ZBTB transcriptional repressor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,088 bases
Position: chr17:2,054,154-2,063,241
Accession: 4909
RBP type: canonical RBP
Summary: This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000382742	zf-C2H2	PF00096.26	2.6e-21	1	4
ENSP00000382742	zf-C2H2	PF00096.26	2.6e-21	2	4
ENSP00000382742	zf-C2H2	PF00096.26	2.6e-21	3	4
ENSP00000382742	zf-C2H2	PF00096.26	2.6e-21	4	4
ENSP00000477858	zf-C2H2	PF00096.26	2.6e-21	1	4
ENSP00000477858	zf-C2H2	PF00096.26	2.6e-21	2	4
ENSP00000477858	zf-C2H2	PF00096.26	2.6e-21	3	4
ENSP00000477858	zf-C2H2	PF00096.26	2.6e-21	4	4
ENSP00000314080	zf-C2H2	PF00096.26	3.1e-21	1	4
ENSP00000314080	zf-C2H2	PF00096.26	3.1e-21	2	4
ENSP00000314080	zf-C2H2	PF00096.26	3.1e-21	3	4
ENSP00000314080	zf-C2H2	PF00096.26	3.1e-21	4	4
ENSP00000382742	zf-met	PF12874.7	5.1e-09	1	2
ENSP00000382742	zf-met	PF12874.7	5.1e-09	2	2
ENSP00000477858	zf-met	PF12874.7	5.1e-09	1	2
ENSP00000477858	zf-met	PF12874.7	5.1e-09	2	2
ENSP00000314080	zf-met	PF12874.7	6e-09	1	2
ENSP00000314080	zf-met	PF12874.7	6e-09	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000571875	HIC1-203	812	-	ENSP00000476554	66 (aa)	-	V9GYA4
ENST00000576444	HIC1-206	725	-	ENSP00000467045	84 (aa)	-	K7ENQ1
ENST00000619757	HIC1-207	6711	-	ENSP00000477858	714 (aa)	-	Q14526
ENST00000322941	HIC1-201	3053	-	ENSP00000314080	733 (aa)	-	Q14526
ENST00000399849	HIC1-202	3156	-	ENSP00000382742	714 (aa)	-	Q14526
ENST00000571990	HIC1-204	654	-	ENSP00000460268	96 (aa)	-	I3L388
ENST00000574370	HIC1-205	1134	-	ENSP00000461476	9 (aa)	-	Q70SM2

Gene Model

Click here to download ENSG00000177374's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177374	rs4480845	17	2055315	T	Total body bone mineral density	29304378	unit decrease	0.0334	EFO_0003923
ENSG00000177374	rs4455005	17	2055242	A	Platelet count	27863252	[0.023-0.038] unit decrease	0.03022036	EFO_0004309
ENSG00000177374	rs4455005	17	2055242	A	Plateletcrit	27863252	[0.031-0.047] unit decrease	0.03903548	EFO_0007985
ENSG00000177374	rs4480845	17	2055315	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000177374	rs3803809	17	2062958	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000177374	rs4455005	17	2055242	G	Pulse pressure	30578418	[0.13-0.23] mmHg decrease	0.1788	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177374's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177374	HIC1	100	86.364	ENSAPOG00000020900	hic1	97	47.919	Acanthochromis_polyacanthus
ENSG00000177374	HIC1	100	100.000	ENSAMEG00000007657	HIC1	78	100.000	Ailuropoda_melanoleuca
ENSG00000177374	HIC1	100	86.364	ENSACIG00000007124	hic1	100	46.792	Amphilophus_citrinellus
ENSG00000177374	HIC1	100	86.364	ENSAOCG00000023291	hic1	97	48.194	Amphiprion_ocellaris
ENSG00000177374	HIC1	100	86.364	ENSAPEG00000008510	hic1	97	47.945	Amphiprion_percula
ENSG00000177374	HIC1	100	86.364	ENSATEG00000021972	hic1	97	47.771	Anabas_testudineus
ENSG00000177374	HIC1	89	86.667	ENSACAG00000011777	HIC1	97	50.270	Anolis_carolinensis
ENSG00000177374	HIC1	100	98.810	ENSANAG00000037442	HIC1	100	94.558	Aotus_nancymaae
ENSG00000177374	HIC1	100	86.364	ENSACLG00000007589	hic1	100	46.368	Astatotilapia_calliptera
ENSG00000177374	HIC1	100	86.364	ENSAMXG00000024869	hic1	97	49.037	Astyanax_mexicanus
ENSG00000177374	HIC1	100	100.000	ENSBTAG00000025130	HIC1	100	97.408	Bos_taurus
ENSG00000177374	HIC1	100	98.810	ENSCJAG00000042739	HIC1	100	98.365	Callithrix_jacchus
ENSG00000177374	HIC1	100	100.000	ENSCAFG00000019257	HIC1	100	96.726	Canis_familiaris
ENSG00000177374	HIC1	100	100.000	ENSCAFG00020009802	HIC1	100	96.779	Canis_lupus_dingo
ENSG00000177374	HIC1	100	100.000	ENSCHIG00000015829	HIC1	100	97.271	Capra_hircus
ENSG00000177374	HIC1	100	100.000	ENSTSYG00000032991	HIC1	100	98.500	Carlito_syrichta
ENSG00000177374	HIC1	100	100.000	ENSCPOG00000020382	HIC1	100	94.270	Cavia_porcellus
ENSG00000177374	HIC1	100	98.958	ENSCCAG00000030944	HIC1	100	98.363	Cebus_capucinus
ENSG00000177374	HIC1	100	100.000	ENSCATG00000037347	HIC1	100	99.181	Cercocebus_atys
ENSG00000177374	HIC1	100	100.000	ENSCLAG00000008072	HIC1	100	96.180	Chinchilla_lanigera
ENSG00000177374	HIC1	100	100.000	ENSCSAG00000013805	HIC1	100	99.318	Chlorocebus_sabaeus
ENSG00000177374	HIC1	100	87.879	ENSCPBG00000000255	HIC1	97	58.771	Chrysemys_picta_bellii
ENSG00000177374	HIC1	100	100.000	ENSCGRG00001018912	Hic1	100	94.679	Cricetulus_griseus_chok1gshd
ENSG00000177374	HIC1	100	100.000	ENSCGRG00000008158	Hic1	100	89.359	Cricetulus_griseus_crigri
ENSG00000177374	HIC1	100	86.364	ENSCSEG00000013032	hic1	94	45.614	Cynoglossus_semilaevis
ENSG00000177374	HIC1	100	86.364	ENSCVAG00000019465	hic1	97	47.607	Cyprinodon_variegatus
ENSG00000177374	HIC1	100	86.364	ENSDARG00000055493	hic1	100	47.564	Danio_rerio
ENSG00000177374	HIC1	100	100.000	ENSDNOG00000049226	HIC1	93	95.562	Dasypus_novemcinctus
ENSG00000177374	HIC1	100	100.000	ENSDORG00000027749	Hic1	62	99.174	Dipodomys_ordii
ENSG00000177374	HIC1	100	100.000	ENSEASG00005009326	HIC1	100	97.059	Equus_asinus_asinus
ENSG00000177374	HIC1	100	100.000	ENSECAG00000030580	HIC1	100	96.726	Equus_caballus
ENSG00000177374	HIC1	100	86.364	ENSELUG00000001329	hic1	97	48.673	Esox_lucius
ENSG00000177374	HIC1	100	100.000	ENSFCAG00000025756	HIC1	100	97.408	Felis_catus
ENSG00000177374	HIC1	86	96.491	ENSFALG00000006543	HIC1	99	59.430	Ficedula_albicollis
ENSG00000177374	HIC1	100	98.810	ENSFDAG00000021489	HIC1	78	97.024	Fukomys_damarensis
ENSG00000177374	HIC1	100	84.848	ENSFHEG00000003606	hic1	99	47.679	Fundulus_heteroclitus
ENSG00000177374	HIC1	100	90.909	ENSGALG00000042077	HIC1	98	61.559	Gallus_gallus
ENSG00000177374	HIC1	100	86.364	ENSGAFG00000012980	hic1	97	46.962	Gambusia_affinis
ENSG00000177374	HIC1	94	87.097	ENSGACG00000010848	hic1	99	50.305	Gasterosteus_aculeatus
ENSG00000177374	HIC1	100	89.394	ENSGAGG00000025616	HIC1	97	58.799	Gopherus_agassizii
ENSG00000177374	HIC1	100	100.000	ENSGGOG00000027584	HIC1	99	100.000	Gorilla_gorilla
ENSG00000177374	HIC1	100	86.364	ENSHBUG00000017815	hic1	97	47.132	Haplochromis_burtoni
ENSG00000177374	HIC1	100	100.000	ENSHGLG00000012044	HIC1	100	94.952	Heterocephalus_glaber_female
ENSG00000177374	HIC1	100	100.000	ENSHGLG00100013587	HIC1	77	99.296	Heterocephalus_glaber_male
ENSG00000177374	HIC1	100	86.364	ENSHCOG00000001420	hic1	97	47.821	Hippocampus_comes
ENSG00000177374	HIC1	100	86.364	ENSIPUG00000004604	hic1	97	49.551	Ictalurus_punctatus
ENSG00000177374	HIC1	100	100.000	ENSSTOG00000011792	HIC1	100	96.332	Ictidomys_tridecemlineatus
ENSG00000177374	HIC1	100	100.000	ENSJJAG00000017367	Hic1	100	95.907	Jaculus_jaculus
ENSG00000177374	HIC1	100	86.364	ENSKMAG00000005746	hic1	97	47.037	Kryptolebias_marmoratus
ENSG00000177374	HIC1	100	84.848	ENSLBEG00000021810	hic1	97	46.173	Labrus_bergylta
ENSG00000177374	HIC1	100	87.879	ENSLACG00000007028	HIC1	97	54.939	Latimeria_chalumnae
ENSG00000177374	HIC1	100	87.879	ENSLOCG00000006478	hic1	86	63.363	Lepisosteus_oculatus
ENSG00000177374	HIC1	100	100.000	ENSLAFG00000001259	HIC1	99	87.761	Loxodonta_africana
ENSG00000177374	HIC1	100	100.000	ENSMFAG00000044684	HIC1	100	99.318	Macaca_fascicularis
ENSG00000177374	HIC1	100	100.000	ENSMMUG00000048710	HIC1	100	99.300	Macaca_mulatta
ENSG00000177374	HIC1	100	100.000	ENSMNEG00000013172	HIC1	100	99.318	Macaca_nemestrina
ENSG00000177374	HIC1	100	86.364	ENSMAMG00000017930	hic1	97	48.673	Mastacembelus_armatus
ENSG00000177374	HIC1	100	86.364	ENSMZEG00005007499	hic1	99	47.073	Maylandia_zebra
ENSG00000177374	HIC1	100	90.909	ENSMGAG00000005397	HIC1	93	72.667	Meleagris_gallopavo
ENSG00000177374	HIC1	100	100.000	ENSMAUG00000019881	Hic1	100	94.952	Mesocricetus_auratus
ENSG00000177374	HIC1	100	100.000	ENSMICG00000012908	HIC1	100	96.317	Microcebus_murinus
ENSG00000177374	HIC1	100	100.000	ENSMOCG00000001275	Hic1	100	91.814	Microtus_ochrogaster
ENSG00000177374	HIC1	100	84.848	ENSMMOG00000014282	hic1	100	47.666	Mola_mola
ENSG00000177374	HIC1	100	97.619	ENSMODG00000010600	HIC1	100	71.754	Monodelphis_domestica
ENSG00000177374	HIC1	100	100.000	MGP_CAROLIEiJ_G0016730	-	81	95.423	Mus_caroli
ENSG00000177374	HIC1	100	100.000	ENSMUSG00000043099	Hic1	81	95.423	Mus_musculus
ENSG00000177374	HIC1	100	100.000	MGP_SPRETEiJ_G0017573	Hic1	100	94.538	Mus_spretus
ENSG00000177374	HIC1	100	100.000	ENSMPUG00000019502	HIC1	100	96.779	Mustela_putorius_furo
ENSG00000177374	HIC1	100	98.810	ENSMLUG00000010527	HIC1	100	95.597	Myotis_lucifugus
ENSG00000177374	HIC1	100	100.000	ENSNGAG00000020689	Hic1	100	93.640	Nannospalax_galili
ENSG00000177374	HIC1	100	86.364	ENSNBRG00000020714	hic1	97	47.015	Neolamprologus_brichardi
ENSG00000177374	HIC1	70	99.601	ENSNLEG00000035047	-	81	99.800	Nomascus_leucogenys
ENSG00000177374	HIC1	100	100.000	ENSODEG00000007964	HIC1	99	95.417	Octodon_degus
ENSG00000177374	HIC1	100	86.364	ENSONIG00000021060	hic1	100	47.500	Oreochromis_niloticus
ENSG00000177374	HIC1	100	86.364	ENSORLG00000029930	hic1	97	46.683	Oryzias_latipes
ENSG00000177374	HIC1	100	86.364	ENSORLG00020008812	hic1	97	46.173	Oryzias_latipes_hni
ENSG00000177374	HIC1	100	86.364	ENSORLG00015000406	hic1	97	46.269	Oryzias_latipes_hsok
ENSG00000177374	HIC1	100	86.364	ENSOMEG00000004793	hic1	97	46.650	Oryzias_melastigma
ENSG00000177374	HIC1	100	100.000	ENSOGAG00000034845	HIC1	100	96.589	Otolemur_garnettii
ENSG00000177374	HIC1	100	100.000	ENSPPRG00000013038	HIC1	100	97.408	Panthera_pardus
ENSG00000177374	HIC1	100	100.000	ENSPTRG00000047506	HIC1	100	100.000	Pan_troglodytes
ENSG00000177374	HIC1	88	90.694	ENSPANG00000024595	HIC1	95	92.751	Papio_anubis
ENSG00000177374	HIC1	100	87.879	ENSPKIG00000000175	hic1	53	50.580	Paramormyrops_kingsleyae
ENSG00000177374	HIC1	78	57.712	ENSPSIG00000007902	HIC1	99	56.870	Pelodiscus_sinensis
ENSG00000177374	HIC1	100	100.000	ENSPEMG00000021229	Hic1	100	95.089	Peromyscus_maniculatus_bairdii
ENSG00000177374	HIC1	100	97.619	ENSPCIG00000019061	HIC1	100	80.764	Phascolarctos_cinereus
ENSG00000177374	HIC1	100	86.364	ENSPFOG00000004471	hic1	97	46.599	Poecilia_formosa
ENSG00000177374	HIC1	100	86.364	ENSPLAG00000022329	hic1	97	46.843	Poecilia_latipinna
ENSG00000177374	HIC1	100	86.364	ENSPMEG00000004584	hic1	97	46.599	Poecilia_mexicana
ENSG00000177374	HIC1	100	86.364	ENSPREG00000010341	hic1	97	47.163	Poecilia_reticulata
ENSG00000177374	HIC1	100	100.000	ENSPPYG00000007789	HIC1	99	100.000	Pongo_abelii
ENSG00000177374	HIC1	100	100.000	ENSPCAG00000000535	HIC1	71	97.458	Procavia_capensis
ENSG00000177374	HIC1	100	100.000	ENSPCOG00000023965	HIC1	100	96.180	Propithecus_coquereli
ENSG00000177374	HIC1	100	100.000	ENSPVAG00000002158	HIC1	100	96.317	Pteropus_vampyrus
ENSG00000177374	HIC1	100	86.364	ENSPNYG00000016207	hic1	97	47.139	Pundamilia_nyererei
ENSG00000177374	HIC1	100	86.364	ENSPNAG00000001133	hic1	99	52.042	Pygocentrus_nattereri
ENSG00000177374	HIC1	75	95.131	ENSRNOG00000046405	Hic1	98	94.867	Rattus_norvegicus
ENSG00000177374	HIC1	100	98.810	ENSRNOG00000057619	LOC100912068	100	92.027	Rattus_norvegicus
ENSG00000177374	HIC1	100	100.000	ENSRROG00000031780	HIC1	100	99.045	Rhinopithecus_roxellana
ENSG00000177374	HIC1	98	86.154	ENSSFOG00015005452	hic1	97	46.221	Scleropages_formosus
ENSG00000177374	HIC1	100	86.364	ENSSMAG00000009823	hic1	97	48.172	Scophthalmus_maximus
ENSG00000177374	HIC1	100	86.364	ENSSDUG00000012062	hic1	97	48.383	Seriola_dumerili
ENSG00000177374	HIC1	100	84.848	ENSSLDG00000002022	hic1	97	48.130	Seriola_lalandi_dorsalis
ENSG00000177374	HIC1	100	100.000	ENSSARG00000010162	-	59	99.170	Sorex_araneus
ENSG00000177374	HIC1	100	89.394	ENSSPUG00000007168	HIC1	98	57.572	Sphenodon_punctatus
ENSG00000177374	HIC1	100	86.364	ENSSPAG00000021973	hic1	100	46.941	Stegastes_partitus
ENSG00000177374	HIC1	100	100.000	ENSSSCG00000025717	HIC1	100	97.139	Sus_scrofa
ENSG00000177374	HIC1	100	92.424	ENSTGUG00000005835	HIC1	99	62.807	Taeniopygia_guttata
ENSG00000177374	HIC1	100	84.848	ENSTRUG00000024667	hic1	97	46.843	Takifugu_rubripes
ENSG00000177374	HIC1	100	100.000	ENSUAMG00000025149	HIC1	100	97.339	Ursus_americanus
ENSG00000177374	HIC1	100	100.000	ENSVVUG00000021725	HIC1	100	96.779	Vulpes_vulpes
ENSG00000177374	HIC1	100	89.394	ENSXETG00000023803	hic1	99	59.059	Xenopus_tropicalis
ENSG00000177374	HIC1	100	86.364	ENSXCOG00000009641	hic1	100	47.037	Xiphophorus_couchianus
ENSG00000177374	HIC1	100	86.364	ENSXMAG00000023343	hic1	97	46.903	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	12052894.15231840.	IDA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0000785	chromatin	-	ISS	Component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	15231840.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	15231840.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	7585125.	TAS	Function
GO:0005515	protein binding	12052894.16724116.16762039.19486893.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	7585125.	TAS	Process
GO:0006974	cellular response to DNA damage stimulus	21873635.	IBA	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	16269335.	IDA	Process
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0030178	negative regulation of Wnt signaling pathway	16724116.	IDA	Process
GO:0042826	histone deacetylase binding	12052894.	IDA	Function
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	-	ISS	Process
GO:0043565	sequence-specific DNA binding	15231840.	IDA	Function
GO:0046872	metal ion binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.