EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	131941678	Missense_Mutation	novel	E311K	0.45	PseudoU_synth_1
BLCA	chr12	131929738	Missense_Mutation	rs587781135	R6C	0.14
BLCA	chr12	131941331	Missense_Mutation	novel	R195T	0.35
BLCA	chr12	131941431	Silent	novel	T228T	0.93
BLCA	chr12	131941959	Silent	novel	L404L	0.24
BLCA	chr12	131941590	Silent	rs765187140	V281V	0.52
BLCA	chr12	131941920	Silent	NA	L391L	0.56
BLCA	chr12	131943707	3'UTR	novel		0.4
BRCA	chr12	131941516	Missense_Mutation	NA	P257S	0.16	PseudoU_synth_1
BRCA	chr12	131939241	Silent	novel	I170I	0.38
BRCA	chr12	131941478	Missense_Mutation	NA	N244S	0.35	PseudoU_synth_1
BRCA	chr12	131941784	Missense_Mutation	rs750169475	R346H	0.22
BRCA	chr12	131943719	3'UTR	novel		0.27
CESC	chr12	131943554	Missense_Mutation	novel	E418K	0.47
CESC	chr12	131941405	Missense_Mutation	novel	E220K	0.48
COAD	chr12	131932272	Missense_Mutation	NA	M134T	0.34
COAD	chr12	131941308	Silent	rs770364021	T187T	0.36
COAD	chr12	131929754	Missense_Mutation	NA	A11V	0.15
COAD	chr12	131941704	Frame_Shift_Del	novel	*T320Qfs72**	0.08	PseudoU_synth_1
COAD	chr12	131932101	Intron	rs774590519		0.29
COAD	chr12	131941812	Silent	rs147555676	P355P	0.31
COAD	chr12	131943657	3'UTR	novel		0.34
COAD	chr12	131929746	Silent	novel	L8L	0.12
COAD	chr12	131941529	Missense_Mutation	rs371146708	R261H	0.35	PseudoU_synth_1
COAD	chr12	131932232	Missense_Mutation	rs770785029	V121I	0.1
COAD	chr12	131941587	Silent	rs760958047	A280A	0.05
COAD	chr12	131929532	5'UTR	novel		0.63
COAD	chr12	131941423	Missense_Mutation	rs376680579	A226T	0.22
DLBC	chr12	131941862	Missense_Mutation	novel	H372R	0.42
GBM	chr12	131941452	Frame_Shift_Ins	novel	*L236Sfs76**	0.63
HNSC	chr12	131929738	Missense_Mutation	rs587781135	R6C	0.46
HNSC	chr12	131941399	Missense_Mutation	novel	Q218E	0.14
KIRP	chr12	131929688	5'UTR	novel		0.34
LAML	chr12	131941319	Missense_Mutation	NA	N191I	0.34
LGG	chr12	131941735	Missense_Mutation	rs769326502	G330R	0.47	PseudoU_synth_1
LIHC	chr12	131939186	Missense_Mutation	NA	A152D	0.48
LIHC	chr12	131943556	Missense_Mutation	novel	E418D	0.5
LUAD	chr12	131941694	Missense_Mutation	NA	R316L	0.29	PseudoU_synth_1
LUAD	chr12	131941642	Missense_Mutation	NA	G299S	0.18	PseudoU_synth_1
LUAD	chr12	131932298	Missense_Mutation	novel	A143S	0.22
LUAD	chr12	131941308	Silent	novel	T187T	0.29
LUSC	chr12	131941751	Missense_Mutation	novel	L335P	0.12	PseudoU_synth_1
LUSC	chr12	131941954	Missense_Mutation	novel	A403S	0.26
LUSC	chr12	131943571	Silent	rs531516145	D423D	0.2
LUSC	chr12	131941731	Silent	novel	A328A	0.28
LUSC	chr12	131930053	Missense_Mutation	novel	D74G	0.37
LUSC	chr12	131941312	Missense_Mutation	novel	G189W	0.34
LUSC	chr12	131941380	Silent	NA	A211A	0.3
OV	chr12	131941673	Missense_Mutation	novel	A309G	0.09	PseudoU_synth_1
OV	chr12	131941367	Missense_Mutation	novel	T207M	0.08
PAAD	chr12	131941975	Missense_Mutation	novel	G410S	0.09
PAAD	chr12	131941610	Missense_Mutation	novel	S288N	0.18	PseudoU_synth_1
READ	chr12	131943678	3'UTR	novel		0.57
READ	chr12	131943666	3'UTR	novel		0.4
SKCM	chr12	131941639	Missense_Mutation	NA	V298F	0.22	PseudoU_synth_1
SKCM	chr12	131941905	Silent	NA	S386S	0.32
SKCM	chr12	131943550	Silent	NA	P416P	0.15
SKCM	chr12	131941323	Silent	NA	S192S	0.1
SKCM	chr12	131941744	Silent	NA	L333L	0.09
SKCM	chr12	131941851	Silent	novel	F368F	0.21
SKCM	chr12	131932298	Missense_Mutation	rs745689913	A143T	0.38
SKCM	chr12	131941322	Missense_Mutation	NA	S192F	0.41
SKCM	chr12	131941516	Missense_Mutation	NA	P257S	0.42	PseudoU_synth_1
STAD	chr12	131941509	Silent	rs555462060	P254P	0.27
STAD	chr12	131932298	Missense_Mutation	rs745689913	A143T	0.4
STAD	chr12	131941508	Missense_Mutation	rs753950876	P254L	0.41	PseudoU_synth_1
STAD	chr12	131932227	Missense_Mutation	NA	A119D	0.24
STAD	chr12	131941527	Silent	NA	C260C	0.27
STAD	chr12	131941336	Missense_Mutation	novel	D197H	0.27
STAD	chr12	131941695	Silent	NA	R316R	0.05
TGCT	chr12	131941611	Missense_Mutation	novel	S288R	0.09	PseudoU_synth_1
THYM	chr12	131941880	Missense_Mutation	novel	I378T	0.32
UCEC	chr12	131932062	Intron	novel		0.25
UCEC	chr12	131941843	Missense_Mutation	rs148218985	A366T	0.34
UCEC	chr12	131941430	Missense_Mutation	rs755448329	T228M	0.24
UCEC	chr12	131941512	Silent	novel	Q255Q	0.56
UCEC	chr12	131929712	5'UTR	novel		0.33
UCEC	chr12	131941886	Missense_Mutation	NA	T380I	0.22
UCEC	chr12	131941550	Missense_Mutation	NA	C268Y	0.32	PseudoU_synth_1
UCEC	chr12	131941437	Missense_Mutation	novel	Q230H	0.29
UCEC	chr12	131941861	Missense_Mutation	novel	H372Y	0.24
UCEC	chr12	131943572	Missense_Mutation	rs548416202	G424R	0.45
UCEC	chr12	131932125	Intron	novel		0.15
UCEC	chr12	131941954	Missense_Mutation	rs771486572	A403T	0.4
UCEC	chr12	131941362	Silent	NA	L205L	0.33
UCEC	chr12	131943566	Frame_Shift_Del	novel	*D423Tfs123**	0.27
UCEC	chr12	131941710	Missense_Mutation	NA	E321D	0.5	PseudoU_synth_1
UCEC	chr12	131932302	Missense_Mutation	rs762199189	R144Q	0.49
UCEC	chr12	131941897	Missense_Mutation	rs138150733	E384K	0.38
UCEC	chr12	131931987	Intron	rs772042722		0.38
UCEC	chr12	131932306	Silent	rs111777451	T145T	0.28
UCEC	chr12	131939182	Missense_Mutation	novel	A151T	0.35
UCEC	chr12	131932080	Intron	novel		0.55
UCEC	chr12	131941641	Silent	rs201908893	V298V	0.15
UCEC	chr12	131941510	Nonsense_Mutation	NA	Q255*	0.22	PseudoU_synth_1
UCEC	chr12	131941602	Missense_Mutation	novel	K285N	0.06	PseudoU_synth_1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.1569	0.22328
BRCA	DEL	0.1593	6.3933e-07
CHOL	DEL	0.1944	0.067545
HNSC	DEL	0.0785	0.22646
LIHC	DEL	0.1243	2.3723e-05
LUAD	DEL	0.1609	0.0059643
LUSC	DEL	0.1218	0.038823
OV	DEL	0.3368	9.8572e-12
PAAD	DEL	0.1739	0.0030251
PRAD	DEL	0.0691	0.024258
SKCM	DEL	0.1853	0.00079981
UCEC	DEL	0.0909	0.00053229
UCS	DEL	0.3393	0.033261

Survival Analysis

Cancer	P-value	Q-value
STAD	0.017	Kaplan-Meier Survival Analysis
SARC	0.011	Kaplan-Meier Survival Analysis
MESO	0.00016	Kaplan-Meier Survival Analysis
ACC	0.0015	Kaplan-Meier Survival Analysis
SKCM	0.05	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
BLCA	0.017	Kaplan-Meier Survival Analysis
GBM	0.019	Kaplan-Meier Survival Analysis
LIHC	0.0016	Kaplan-Meier Survival Analysis
LGG	0.00041	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.0055	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177192 (Gene tree)
Gene ID: 80324
Gene Symbol: PUS1
Alias: N
Full Name: pseudouridine synthase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 16,697 bases
Position: chr12:131,929,200-131,945,896
Accession: 15508
RBP type: canonical RBP
Summary: This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000324726	PseudoU_synth_1	PF01416.20	5.2e-15	1	1
ENSP00000392451	PseudoU_synth_1	PF01416.20	6e-15	1	1
ENSP00000438948	PseudoU_synth_1	PF01416.20	6.6e-15	1	1
ENSP00000365837	PseudoU_synth_1	PF01416.20	7.5e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10492022	RNA:pseudouridine synthetase Pus1 from Saccharomyces cerevisiae: oligomerization property and stoichiometry of the complex with yeast tRNA(Phe).	Biochimie	1999 Jul	Arluison V	-
23707380	In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities.	J Mol Biol	2013 Oct 23	Czudnochowski N	doi: 10.1016/j.jmb.2013.05.014
19731322	Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations.	Pediatr Blood Cancer	2010 Feb	Bergmann AK	doi: 10.1002/pbc.22244.
24003969	Pathophysiology and genetic mutations in congenital sideroblastic anemia.	Pediatr Int	2013 Dec	Fujiwara T	doi: 10.1111/ped.12217.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000376649	PUS1-202	4094	-	ENSP00000365837	427 (aa)	-	Q9Y606
ENST00000543754	PUS1-209	1378	-	-	- (aa)	-	-
ENST00000542167	PUS1-208	2151	XM_011538768	ENSP00000438948	374 (aa)	XP_011537070	F5H1S9
ENST00000456665	PUS1-204	577	-	ENSP00000409705	156 (aa)	-	F8W9U5
ENST00000544213	PUS1-210	687	XM_011538769	ENSP00000445819	184 (aa)	XP_011537071	F5H1B2
ENST00000322060	PUS1-201	1206	-	ENSP00000324726	384 (aa)	-	G8JLB3
ENST00000544662	PUS1-211	836	-	-	- (aa)	-	-
ENST00000535067	PUS1-205	838	-	ENSP00000443969	134 (aa)	-	F5H168
ENST00000538037	PUS1-207	631	-	ENSP00000440326	153 (aa)	-	F5GY32
ENST00000443358	PUS1-203	1664	-	ENSP00000392451	399 (aa)	-	Q9Y606
ENST00000537484	PUS1-206	642	-	ENSP00000440179	200 (aa)	-	F5GXL3

Gene Model

Click here to download ENSG00000177192's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000177192	Platelet Function Tests	6.3537297E-006	-
ENSG00000177192	Alzheimer Disease	4E-6	26993346
ENSG00000177192	Neurodegenerative Diseases	4E-6	26993346

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177192	rs4965006	12	131934988	?	Posterior cortical atrophy and Alzheimer's disease	26993346	[1.29704-1.96399]	1.59605	EFO_0000249\|Orphanet_54247

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177192's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177192	PUS1	88	69.405	ENSAPOG00000007254	pus1	83	69.405	Acanthochromis_polyacanthus
ENSG00000177192	PUS1	100	81.510	ENSAMEG00000013715	PUS1	98	79.475	Ailuropoda_melanoleuca
ENSG00000177192	PUS1	88	72.059	ENSACIG00000009169	pus1	83	72.059	Amphilophus_citrinellus
ENSG00000177192	PUS1	90	69.859	ENSAOCG00000022207	pus1	84	69.859	Amphiprion_ocellaris
ENSG00000177192	PUS1	90	69.859	ENSAPEG00000006039	pus1	91	69.859	Amphiprion_percula
ENSG00000177192	PUS1	91	68.156	ENSATEG00000020688	pus1	91	68.451	Anabas_testudineus
ENSG00000177192	PUS1	90	78.035	ENSACAG00000007367	PUS1	93	78.035	Anolis_carolinensis
ENSG00000177192	PUS1	87	94.785	ENSANAG00000036192	PUS1	100	94.785	Aotus_nancymaae
ENSG00000177192	PUS1	88	71.554	ENSACLG00000020868	pus1	92	68.681	Astatotilapia_calliptera
ENSG00000177192	PUS1	89	72.093	ENSAMXG00000008710	pus1	80	72.093	Astyanax_mexicanus
ENSG00000177192	PUS1	100	84.156	ENSBTAG00000012990	PUS1	100	83.500	Bos_taurus
ENSG00000177192	PUS1	87	39.143	WBGene00004248	pus-1	83	39.143	Caenorhabditis_elegans
ENSG00000177192	PUS1	68	96.063	ENSCJAG00000003720	PUS1	73	95.131	Callithrix_jacchus
ENSG00000177192	PUS1	100	82.519	ENSCAFG00000006429	PUS1	100	82.161	Canis_familiaris
ENSG00000177192	PUS1	97	84.350	ENSCAFG00020010737	PUS1	99	79.343	Canis_lupus_dingo
ENSG00000177192	PUS1	100	83.896	ENSCHIG00000000487	PUS1	100	83.250	Capra_hircus
ENSG00000177192	PUS1	92	89.160	ENSTSYG00000032605	PUS1	100	89.160	Carlito_syrichta
ENSG00000177192	PUS1	80	91.611	ENSCAPG00000006421	PUS1	100	88.272	Cavia_aperea
ENSG00000177192	PUS1	91	87.356	ENSCPOG00000001027	PUS1	98	80.142	Cavia_porcellus
ENSG00000177192	PUS1	100	93.750	ENSCCAG00000015879	PUS1	100	92.991	Cebus_capucinus
ENSG00000177192	PUS1	100	95.833	ENSCATG00000032870	PUS1	100	95.785	Cercocebus_atys
ENSG00000177192	PUS1	97	84.097	ENSCLAG00000011689	PUS1	99	80.140	Chinchilla_lanigera
ENSG00000177192	PUS1	100	95.316	ENSCSAG00000001879	PUS1	100	95.316	Chlorocebus_sabaeus
ENSG00000177192	PUS1	90	78.869	ENSCPBG00000024715	PUS1	100	75.900	Chrysemys_picta_bellii
ENSG00000177192	PUS1	86	42.690	ENSCING00000009426	-	91	42.690	Ciona_intestinalis
ENSG00000177192	PUS1	86	42.398	ENSCSAVG00000003751	-	71	42.398	Ciona_savignyi
ENSG00000177192	PUS1	100	86.216	ENSCANG00000035561	PUS1	100	86.318	Colobus_angolensis_palliatus
ENSG00000177192	PUS1	100	86.216	ENSCGRG00001019592	Pus1	98	84.561	Cricetulus_griseus_chok1gshd
ENSG00000177192	PUS1	100	86.216	ENSCGRG00000004048	Pus1	100	86.216	Cricetulus_griseus_crigri
ENSG00000177192	PUS1	88	69.527	ENSCSEG00000003629	pus1	80	69.527	Cynoglossus_semilaevis
ENSG00000177192	PUS1	90	70.809	ENSCVAG00000001265	pus1	89	68.392	Cyprinodon_variegatus
ENSG00000177192	PUS1	94	65.833	ENSDARG00000045562	pus1	95	68.561	Danio_rerio
ENSG00000177192	PUS1	99	78.329	ENSDNOG00000045576	PUS1	98	83.851	Dasypus_novemcinctus
ENSG00000177192	PUS1	87	91.411	ENSDORG00000011455	Pus1	100	91.411	Dipodomys_ordii
ENSG00000177192	PUS1	87	46.364	FBgn0038811	PUS1	78	48.447	Drosophila_melanogaster
ENSG00000177192	PUS1	94	79.614	ENSETEG00000019160	PUS1	99	73.775	Echinops_telfairi
ENSG00000177192	PUS1	83	43.109	ENSEBUG00000000368	-	63	43.109	Eptatretus_burgeri
ENSG00000177192	PUS1	100	85.323	ENSEASG00005016535	PUS1	100	82.759	Equus_asinus_asinus
ENSG00000177192	PUS1	100	86.070	ENSECAG00000006965	PUS1	100	86.070	Equus_caballus
ENSG00000177192	PUS1	90	71.023	ENSELUG00000010424	pus1	91	68.681	Esox_lucius
ENSG00000177192	PUS1	100	81.299	ENSFCAG00000010780	PUS1	95	79.657	Felis_catus
ENSG00000177192	PUS1	97	78.191	ENSFALG00000008273	PUS1	95	74.631	Ficedula_albicollis
ENSG00000177192	PUS1	93	87.535	ENSFDAG00000012518	PUS1	98	80.569	Fukomys_damarensis
ENSG00000177192	PUS1	90	70.809	ENSFHEG00000010504	pus1	88	68.120	Fundulus_heteroclitus
ENSG00000177192	PUS1	89	68.116	ENSGMOG00000008143	pus1	89	68.116	Gadus_morhua
ENSG00000177192	PUS1	90	80.460	ENSGALG00000002354	PUS1	91	77.898	Gallus_gallus
ENSG00000177192	PUS1	91	70.085	ENSGAFG00000006578	pus1	89	67.473	Gambusia_affinis
ENSG00000177192	PUS1	90	69.364	ENSGACG00000017566	pus1	88	69.364	Gasterosteus_aculeatus
ENSG00000177192	PUS1	90	77.976	ENSGAGG00000016730	-	94	78.614	Gopherus_agassizii
ENSG00000177192	PUS1	100	98.663	ENSGGOG00000009178	PUS1	100	98.663	Gorilla_gorilla
ENSG00000177192	PUS1	88	71.848	ENSHBUG00000001316	pus1	92	68.956	Haplochromis_burtoni
ENSG00000177192	PUS1	93	85.393	ENSHGLG00000016086	PUS1	100	81.612	Heterocephalus_glaber_female
ENSG00000177192	PUS1	93	85.112	ENSHGLG00100019362	PUS1	100	81.108	Heterocephalus_glaber_male
ENSG00000177192	PUS1	88	71.345	ENSHCOG00000014288	pus1	79	71.345	Hippocampus_comes
ENSG00000177192	PUS1	89	75.294	ENSIPUG00000010387	pus1	85	75.294	Ictalurus_punctatus
ENSG00000177192	PUS1	100	85.156	ENSSTOG00000011245	PUS1	99	83.099	Ictidomys_tridecemlineatus
ENSG00000177192	PUS1	100	84.211	ENSJJAG00000000088	Pus1	98	82.660	Jaculus_jaculus
ENSG00000177192	PUS1	86	70.060	ENSKMAG00000012702	pus1	85	67.606	Kryptolebias_marmoratus
ENSG00000177192	PUS1	89	69.855	ENSLBEG00000002845	pus1	90	66.849	Labrus_bergylta
ENSG00000177192	PUS1	84	56.347	ENSLACG00000016044	-	98	56.347	Latimeria_chalumnae
ENSG00000177192	PUS1	98	72.823	ENSLACG00000018598	PUS1	99	69.727	Latimeria_chalumnae
ENSG00000177192	PUS1	91	76.857	ENSLOCG00000006127	pus1	92	75.000	Lepisosteus_oculatus
ENSG00000177192	PUS1	93	81.402	ENSLAFG00000028731	PUS1	100	81.402	Loxodonta_africana
ENSG00000177192	PUS1	100	95.573	ENSMFAG00000041194	PUS1	100	95.522	Macaca_fascicularis
ENSG00000177192	PUS1	100	96.094	ENSMMUG00000031463	PUS1	100	96.124	Macaca_mulatta
ENSG00000177192	PUS1	100	96.094	ENSMNEG00000002814	PUS1	100	96.019	Macaca_nemestrina
ENSG00000177192	PUS1	100	94.385	ENSMLEG00000043560	PUS1	100	98.160	Mandrillus_leucophaeus
ENSG00000177192	PUS1	89	69.006	ENSMAMG00000007371	pus1	81	69.006	Mastacembelus_armatus
ENSG00000177192	PUS1	88	71.848	ENSMZEG00005017746	pus1	86	68.956	Maylandia_zebra
ENSG00000177192	PUS1	87	81.212	ENSMGAG00000001958	PUS1	100	81.212	Meleagris_gallopavo
ENSG00000177192	PUS1	100	85.965	ENSMAUG00000001482	Pus1	98	84.323	Mesocricetus_auratus
ENSG00000177192	PUS1	100	85.938	ENSMICG00000030980	PUS1	100	84.653	Microcebus_murinus
ENSG00000177192	PUS1	100	86.717	ENSMOCG00000022311	Pus1	98	85.036	Microtus_ochrogaster
ENSG00000177192	PUS1	90	69.628	ENSMMOG00000021022	pus1	93	67.760	Mola_mola
ENSG00000177192	PUS1	85	83.385	ENSMODG00000015551	PUS1	84	77.540	Monodelphis_domestica
ENSG00000177192	PUS1	89	69.006	ENSMALG00000013202	pus1	87	66.851	Monopterus_albus
ENSG00000177192	PUS1	100	86.466	MGP_CAROLIEiJ_G0027551	Pus1	100	86.466	Mus_caroli
ENSG00000177192	PUS1	100	86.466	ENSMUSG00000029507	Pus1	100	86.466	Mus_musculus
ENSG00000177192	PUS1	100	86.216	MGP_PahariEiJ_G0024133	Pus1	100	86.216	Mus_pahari
ENSG00000177192	PUS1	100	86.466	MGP_SPRETEiJ_G0028549	Pus1	100	86.466	Mus_spretus
ENSG00000177192	PUS1	100	82.857	ENSMPUG00000002314	PUS1	100	81.910	Mustela_putorius_furo
ENSG00000177192	PUS1	91	85.286	ENSMLUG00000015790	PUS1	99	85.286	Myotis_lucifugus
ENSG00000177192	PUS1	99	87.071	ENSNGAG00000012976	Pus1	98	84.798	Nannospalax_galili
ENSG00000177192	PUS1	88	71.554	ENSNBRG00000020502	pus1	92	71.554	Neolamprologus_brichardi
ENSG00000177192	PUS1	95	94.723	ENSNLEG00000008505	PUS1	100	97.792	Nomascus_leucogenys
ENSG00000177192	PUS1	96	68.835	ENSMEUG00000002825	PUS1	98	68.835	Notamacropus_eugenii
ENSG00000177192	PUS1	100	74.740	ENSOPRG00000002701	-	100	74.419	Ochotona_princeps
ENSG00000177192	PUS1	99	84.169	ENSODEG00000008248	PUS1	98	84.169	Octodon_degus
ENSG00000177192	PUS1	88	70.520	ENSONIG00000003803	pus1	94	68.468	Oreochromis_niloticus
ENSG00000177192	PUS1	98	75.926	ENSOANG00000010619	PUS1	97	72.038	Ornithorhynchus_anatinus
ENSG00000177192	PUS1	97	85.255	ENSOCUG00000007310	PUS1	84	84.755	Oryctolagus_cuniculus
ENSG00000177192	PUS1	85	72.340	ENSORLG00000010787	pus1	84	69.714	Oryzias_latipes
ENSG00000177192	PUS1	85	72.948	ENSORLG00020011483	pus1	84	70.286	Oryzias_latipes_hni
ENSG00000177192	PUS1	85	73.252	ENSORLG00015023012	pus1	90	70.571	Oryzias_latipes_hsok
ENSG00000177192	PUS1	90	69.653	ENSOMEG00000022655	pus1	85	67.036	Oryzias_melastigma
ENSG00000177192	PUS1	96	88.571	ENSOGAG00000008720	PUS1	100	88.571	Otolemur_garnettii
ENSG00000177192	PUS1	100	83.896	ENSOARG00000013316	PUS1	97	81.517	Ovis_aries
ENSG00000177192	PUS1	100	99.297	ENSPPAG00000040971	PUS1	100	99.297	Pan_paniscus
ENSG00000177192	PUS1	100	81.558	ENSPPRG00000015456	PUS1	100	80.653	Panthera_pardus
ENSG00000177192	PUS1	89	85.423	ENSPTIG00000004201	PUS1	92	84.225	Panthera_tigris_altaica
ENSG00000177192	PUS1	100	98.747	ENSPTRG00000005643	PUS1	100	98.595	Pan_troglodytes
ENSG00000177192	PUS1	100	95.833	ENSPANG00000000376	PUS1	100	95.785	Papio_anubis
ENSG00000177192	PUS1	91	72.805	ENSPKIG00000019369	pus1	80	72.805	Paramormyrops_kingsleyae
ENSG00000177192	PUS1	98	76.127	ENSPSIG00000016432	PUS1	92	72.840	Pelodiscus_sinensis
ENSG00000177192	PUS1	92	68.820	ENSPMGG00000004522	pus1	93	68.820	Periophthalmus_magnuspinnatus
ENSG00000177192	PUS1	100	86.717	ENSPEMG00000013448	Pus1	98	85.036	Peromyscus_maniculatus_bairdii
ENSG00000177192	PUS1	86	60.606	ENSPMAG00000004636	pus1	100	60.606	Petromyzon_marinus
ENSG00000177192	PUS1	67	80.159	ENSPCIG00000022609	-	66	75.357	Phascolarctos_cinereus
ENSG00000177192	PUS1	91	69.231	ENSPFOG00000019669	pus1	89	66.667	Poecilia_formosa
ENSG00000177192	PUS1	91	69.231	ENSPLAG00000002692	-	89	66.667	Poecilia_latipinna
ENSG00000177192	PUS1	91	69.231	ENSPLAG00000007185	pus1	89	66.667	Poecilia_latipinna
ENSG00000177192	PUS1	91	69.231	ENSPMEG00000006038	pus1	92	66.667	Poecilia_mexicana
ENSG00000177192	PUS1	91	69.231	ENSPMEG00000011115	PUS1	89	66.667	Poecilia_mexicana
ENSG00000177192	PUS1	91	69.516	ENSPREG00000007231	pus1	98	68.644	Poecilia_reticulata
ENSG00000177192	PUS1	100	96.491	ENSPPYG00000005132	PUS1	100	96.487	Pongo_abelii
ENSG00000177192	PUS1	69	80.545	ENSPCAG00000009110	-	63	80.545	Procavia_capensis
ENSG00000177192	PUS1	100	79.500	ENSPCOG00000015595	PUS1	100	79.500	Propithecus_coquereli
ENSG00000177192	PUS1	88	71.554	ENSPNYG00000013571	pus1	86	68.681	Pundamilia_nyererei
ENSG00000177192	PUS1	89	73.256	ENSPNAG00000003938	pus1	82	73.256	Pygocentrus_nattereri
ENSG00000177192	PUS1	100	86.216	ENSRNOG00000037500	Pus1	98	84.798	Rattus_norvegicus
ENSG00000177192	PUS1	100	95.238	ENSRBIG00000043177	PUS1	100	95.238	Rhinopithecus_bieti
ENSG00000177192	PUS1	100	94.737	ENSRROG00000039744	PUS1	100	94.614	Rhinopithecus_roxellana
ENSG00000177192	PUS1	78	31.492	YGL063W	-	96	31.319	Saccharomyces_cerevisiae
ENSG00000177192	PUS1	80	44.615	YPL212C	-	62	39.877	Saccharomyces_cerevisiae
ENSG00000177192	PUS1	100	94.286	ENSSBOG00000023593	PUS1	100	94.250	Saimiri_boliviensis_boliviensis
ENSG00000177192	PUS1	97	76.267	ENSSHAG00000013193	PUS1	95	73.858	Sarcophilus_harrisii
ENSG00000177192	PUS1	95	72.826	ENSSFOG00015003463	pus1	84	72.826	Scleropages_formosus
ENSG00000177192	PUS1	88	70.000	ENSSMAG00000019075	pus1	95	61.614	Scophthalmus_maximus
ENSG00000177192	PUS1	88	71.765	ENSSDUG00000007102	pus1	86	69.252	Seriola_dumerili
ENSG00000177192	PUS1	88	71.176	ENSSLDG00000022850	pus1	86	68.698	Seriola_lalandi_dorsalis
ENSG00000177192	PUS1	82	75.570	ENSSARG00000008367	PUS1	99	75.570	Sorex_araneus
ENSG00000177192	PUS1	97	75.603	ENSSPUG00000010009	PUS1	99	73.250	Sphenodon_punctatus
ENSG00000177192	PUS1	86	72.810	ENSSPAG00000006272	pus1	91	68.627	Stegastes_partitus
ENSG00000177192	PUS1	100	84.416	ENSSSCG00000009741	PUS1	100	84.250	Sus_scrofa
ENSG00000177192	PUS1	86	83.030	ENSTGUG00000008068	PUS1	100	83.030	Taeniopygia_guttata
ENSG00000177192	PUS1	90	67.218	ENSTRUG00000002198	pus1	93	67.218	Takifugu_rubripes
ENSG00000177192	PUS1	90	67.429	ENSTNIG00000003942	pus1	93	65.940	Tetraodon_nigroviridis
ENSG00000177192	PUS1	100	82.429	ENSTTRG00000000632	PUS1	99	80.714	Tursiops_truncatus
ENSG00000177192	PUS1	100	84.156	ENSUAMG00000017197	PUS1	100	83.417	Ursus_americanus
ENSG00000177192	PUS1	97	83.957	ENSUMAG00000002831	PUS1	100	87.500	Ursus_maritimus
ENSG00000177192	PUS1	100	82.338	ENSVVUG00000004199	PUS1	92	80.198	Vulpes_vulpes
ENSG00000177192	PUS1	83	50.157	ENSXETG00000033640	-	99	50.157	Xenopus_tropicalis
ENSG00000177192	PUS1	93	73.816	ENSXETG00000002030	pus1	93	71.390	Xenopus_tropicalis
ENSG00000177192	PUS1	91	69.801	ENSXCOG00000004722	pus1	96	66.846	Xiphophorus_couchianus
ENSG00000177192	PUS1	91	69.516	ENSXMAG00000000988	pus1	89	66.935	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	23707380.	IDA	Function
GO:0002153	steroid receptor RNA activator RNA binding	24722331.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0009982	pseudouridine synthase activity	15772074.22102571.	EXP	Function
GO:0009982	pseudouridine synthase activity	21873635.	IBA	Function
GO:0009982	pseudouridine synthase activity	24722331.	IMP	Function
GO:0031119	tRNA pseudouridine synthesis	21873635.	IBA	Process
GO:0070902	mitochondrial tRNA pseudouridine synthesis	-	TAS	Process
GO:0106029	tRNA pseudouridine synthase activity	-	IEA	Function
GO:1990481	mRNA pseudouridine synthesis	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.