EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29588366The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1.J Biol Chem2018 May 25Chen Zdoi: 10.1074/jbc.RA117.001321
22751924c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.Mol Cell Biol2012 SepBjrkblom Bdoi: 10.1128/MCB.00713-12

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr132334792SilentnovelI131I0.48
BLCAchr132334903SilentnovelF94F0.14
BRCAchr132335011Silentrs142561179A58A0.55
BRCAchr132334829Missense_MutationNAS119C0.41
COADchr132334853Frame_Shift_DelnovelE111Gfs*870.17
COADchr132334705Missense_MutationnovelE160D0.5
COADchr132334875Missense_MutationNAS104P0.3
COADchr132334705Missense_MutationnovelE160D0.46
COADchr132334939Frame_Shift_DelNAK83Rfs*180.38
COADchr1323345383'UTRnovel0.2
COADchr132334994Missense_MutationNAA64V0.4
DLBCchr1323360915'UTRnovel0.35
DLBCchr132334853Missense_MutationnovelE111V0.27
ESCAchr132334683Missense_MutationnovelE168Q0.06
GBMchr1323360495'UTRnovel0.14
GBMchr1323345433'UTRnovel0.48
HNSCchr132334637Missense_MutationnovelE183V0.29
HNSCchr132334638Missense_MutationnovelE183Q0.3
LGGchr132335036Missense_Mutationrs757947035P50L0.7
LGGchr132334835Missense_MutationnovelS117Y0.4
LIHCchr132334863Frame_Shift_DelnovelF105Efs*60.8
LUADchr1323345773'UTRnovel0.31
LUSCchr132334882Missense_MutationNAS101R0.27
OVchr132334923Missense_MutationnovelK88Q0.07
OVchr132334809Nonsense_MutationNAQ126*0.39
OVchr132334740Missense_MutationnovelP149S0.22
READchr1323345583'UTRnovel0.26
SARCchr132334703Missense_MutationnovelA161D0.14
SKCMchr132334708SilentNAA159A0.06
SKCMchr132334650Missense_MutationNAP179S0.17
SKCMchr132334832Missense_MutationnovelA118V0.24
SKCMchr132335063Missense_Mutationrs374147732S41F0.24
STADchr132335979Missense_MutationNAA19T0.17
STADchr132334875Missense_MutationNAS104P0.16
STADchr1323345303'UTRnovel0.22
STADchr1323360365'UTRnovel0.17
THCAchr1323345783'UTRnovel0.25
UCECchr1323345553'UTRnovel0.12
UCECchr132334909Missense_Mutationrs770620654F92L0.11
UCECchr132334865Missense_MutationNAR107I0.25
UCECchr1323341233'UTRnovel0.24
UCECchr1323338793'UTRnovel0.53
UCECchr1323342663'UTRnovel0.48
UCECchr132334620Missense_MutationnovelA189T0.08
UCECchr132334938Frame_Shift_Insrs749563695K83Qfs*330.39
UCECchr1323344413'UTRnovel0.15
UCECchr1323345753'UTRnovel0.19
UCECchr132334909Missense_Mutationrs770620654F92L0.5
UCECchr132334909Missense_Mutationrs770620654F92L0.77
UCECchr132334921SilentnovelK88K0.24
UCECchr1323339893'UTRnovel0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.1250.011841
LIHCDEL0.32161.6679e-20
TGCTDEL0.140.00046313

Survival Analysis
CancerP-value Q-value
KIRC0.023

Kaplan-Meier Survival Analysis

SARC0.00011

Kaplan-Meier Survival Analysis

ACC0.0024

Kaplan-Meier Survival Analysis

TGCT0.047

Kaplan-Meier Survival Analysis

COAD0.032

Kaplan-Meier Survival Analysis

PCPG0.034

Kaplan-Meier Survival Analysis

LAML0.0088

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.0075

Kaplan-Meier Survival Analysis

OV0.015

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000175130 (Gene tree)
Gene ID
65108
Gene Symbol
MARCKSL1
Alias
F52|MacMARCKS|MLP1|MLP
Full Name
MARCKS like 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
2,551 bases
Position
chr1:32,333,829-32,336,379
Accession
7142
RBP type
non-canonical RBP
Summary
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10523674Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation.Mol Cell Biol1999 NovCai T-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000329421MARCKSL1-2011699-ENSP00000362638195 (aa)-P49006
Gene Model
Click here to download ENSG00000175130's gene model file
Pathways
Pathway IDPathway NameSource
hsa04666Fc gamma R-mediated phagocytosisKEGG
hsa05140LeishmaniasisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175130's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003779actin binding-IEAFunction
GO:0005515protein binding24863880.IPIFunction
GO:0005516calmodulin binding-IEAFunction
GO:0005737cytoplasm-IEAComponent
GO:0005856cytoskeleton-IEAComponent
GO:0005886plasma membrane-IDAComponent
GO:0008284positive regulation of cell proliferation-IEAProcess
GO:0070062extracellular exosome20458337.HDAComponent
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