EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23240926	Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.	Thyroid	2013 Jan	Ciampi R	doi: 10.1089/thy.2012.0207
26522772	H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases.	J Pediatr Urol	2016 Apr	Castillo-Martin M	doi: 10.1016/j.jpurol.2015.08.020
21330833	Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.	Int J Gynecol Cancer	2011 Jan	Wegman P	doi: 10.1097/IGC.0b013e3182049924.
27074591	Impact of SNPs on CpG Islands in the MYC and HRAS oncogenes and in a wide variety of tumor suppressor genes: A multi-cancer approach.	Cell Cycle	2016 Jun 17	Samy MD	doi: 10.1080/15384101.2016.1164360.
28371260	Phenotypic spectrum of Costello syndrome individuals harboring the rare HRAS mutation p.Gly13Asp.	Am J Med Genet A	2017 May	Bertola D	doi: 10.1002/ajmg.a.38178
22427690	Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature.	J Cell Sci	2012 Jul 1	Solomon H	doi: 10.1242/jcs.099663
22982396	Oncogene Ras/phosphatidylinositol 3-kinase signaling targets histone H3 acetylation at lysine 56.	J Biol Chem	2012 Nov 30	Liu Y	doi: 10.1074/jbc.M112.367847
19254697	Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.	Biochem Biophys Res Commun	2009 Apr 17	Wilder PJ	doi: 10.1016/j.bbrc.2009.02.126
17374253	[K-ras mutation analysis in ovarian serous borderline and malignant tumors].	Zhonghua Bing Li Xue Za Zhi	2006 Dec	Ma L	-
23028055	Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions.	J Immunol	2012 Nov 1	Vernitsky H	doi: 10.4049/jimmunol.1200019
22573884	Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.	Mol Biol Cell	2012 Jul	Schmees C	doi: 10.1091/mbc.E11-04-0317
16286246	Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.	Cancer Cell	2005 Nov	Lim KH	-
19101897	Mutations of RAS gene family in specimens of bladder cancer.	Urol J	2008 Fall	Karimianpour N	-
17096025	The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.	Cell Death Differ	2007 May	Shapira S	-
21665306	In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.	Radiother Oncol	2011 Oct	Myllynen L	doi: 10.1016/j.radonc.2011.05.046
15816642	Persistence of K-ras mutations in plasma after colorectal tumor resection.	Anticancer Res	2005 Jan-Feb	Lindforss U	-
19140325	[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas].	Mol Biol (Mosk)	2008 Nov-Dec	Nemtsova MN	-
22589270	A comprehensive survey of Ras mutations in cancer.	Cancer Res	2012 May 15	Prior IA	doi: 10.1158/0008-5472.CAN-11-2612.
16738062	p19ras brings a new twist to the regulation of p73 by Mdm2.	Sci STKE	2006 May 30	Harms KL	-
23583409	p53 Attenuates the oncogenic Ras-induced epithelial-mesenchymal transition in human mammary epithelial cells.	Biochem Biophys Res Commun	2013 May 10	Zhang J	doi: 10.1016/j.bbrc.2013.03.124
21473856	RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage.	Biochem Biophys Res Commun	2011 Apr 29	Park SH	doi: 10.1016/j.bbrc.2011.03.139
18465119	Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.	Arch Toxicol	2008 Oct	Jin M	doi: 10.1007/s00204-008-0293-y
19855428	Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.	Oncogene	2009 Dec 17	Aylon Y	doi: 10.1038/onc.2009.270
26620726	MicroRNAs: Modulators of the Ras Oncogenes in Oral Cancer.	J Cell Physiol	2016 Jul	Murugan AK	doi: 10.1002/jcp.25269
26560143	Absolute Quantification of Endogenous Ras Isoform Abundance.	PLoS One	2015 Nov 11	Mageean CJ	doi: 10.1371/journal.pone.0142674
24908601	Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma.	Oral Surg Oral Med Oral Pathol Oral Radiol	2014 Jul	Chang YS	doi: 10.1016/j.oooo.2014.03.016
26568031	Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.	Biochemistry	2015 Dec 15	Najumudeen AK	doi: 10.1021/acs.biochem.5b00724
27913610	Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome.	Eur J Endocrinol	2017 Feb	Li Y	-
30655611	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	Nat Commun	2019 Jan 17	Jeong WJ	doi: 10.1038/s41467-018-08230-6.
22490849	[Association between H-ras and L-myc gene polymorphisms and susceptibility to colorectal cancer].	Zhonghua Zhong Liu Za Zhi	2012 Jan	Ni Q	-
28259994	Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.	Int J Mol Med	2017 Apr	Bai S	doi: 10.3892/ijmm.2017.2903
16857742	Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells.	Mol Pharmacol	2006 Oct	Yeh CW	-
22707223	Methylation pattern of oncogene HRAS gene promoter region and its clinical relevance to urocystic tumorigenesis.	Mol Biol Rep	2012 Aug	Sun XF	doi: 10.1007/s11033-012-1696-7
18783589	Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.	BMC Cancer	2008 Sep 10	Zhang Y	doi: 10.1186/1471-2407-8-256.
23264394	Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.	J Clin Endocrinol Metab	2013 Feb	Agrawal N	doi: 10.1210/jc.2012-2703
21080251	Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.	Tumour Biol	2011 Apr	Chen HC	doi: 10.1007/s13277-010-0129-2
21514184	HRAS T81C polymorphism modulates risk of urinary bladder cancer and predicts advanced tumors in ethnic Kashmiri population.	Urol Oncol	2013 May	Pandith AA	doi: 10.1016/j.urolonc.2011.03.004
24648519	Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.	J Biol Chem	2014 May 16	Wang Y	doi: 10.1074/jbc.M113.527671
11788888	Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.	Int J Oncol	2002 Feb	Schondorf T	-
18655729	Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?	BMC Cancer	2008 Jul 27	Kristensen AT	doi: 10.1186/1471-2407-8-213.
20848283	The role of K-ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.	Cancer Chemother Pharmacol	2011 Feb	Sahu RP	doi: 10.1007/s00280-010-1463-1
23150177	Lack of mutational events of RAS genes in sporadic thyroid cancer but high risk associated with HRAS T81C single nucleotide polymorphism (case-control study).	Tumour Biol	2013 Feb	Khan MS	doi: 10.1007/s13277-012-0577-y
18296105	Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: results from the Netherlands Cohort Study.	Mutat Res	2008 Mar 29	Weijenberg MP	doi: 10.1016/j.mrgentox.2007.12.008
26799184	Comparison of liver oncogenic potential among human RAS isoforms.	Oncotarget	2016 Feb 9	Chung SI	doi: 10.18632/oncotarget.6931.
18677112	Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.	Cell Cycle	2008 Aug	Park Y	-
21826673	Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.	J Surg Oncol	2012 Jan	Na KY	doi: 10.1002/jso.22064
23722551	4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.	Cancer Res	2013 Jul 15	Kohli L	doi: 10.1158/0008-5472.CAN-12-3765
21336946	Limited evidence supported the association of HRAS1 polymorphism with breast cancer risk.	Breast Cancer Res Treat	2011 Jul	Zhang X	doi: 10.1007/s10549-011-1407-4
15638373	Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.	Rocz Akad Med Bialymst	2004	Okulczyk B	-
23168708	Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.	Indian J Med Res	2012 Oct	Saxena A	-
22324744	DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.	Eur J Clin Invest	2012 Jul	Xu XM	doi: 10.1111/j.1365-2362.2011.02641.x
20038817	Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.	Cancer Biol Ther	2009 Dec	Navaraj A	-
21221763	Current evidence on the relationship between HRAS1 polymorphism and breast cancer risk: a meta-analysis.	Breast Cancer Res Treat	2011 Jul	Zhang C	doi: 10.1007/s10549-011-1344-2
16384911	RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.	FASEB J	2006 Mar	Mei FC	-
17018607	Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.	Cancer Res	2006 Oct 1	Datta D	-
26969876	Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients.	Cancer	2016 May 1	Song YS	doi: 10.1002/cncr.29934
16760302	Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.	Ann Oncol	2006 Jun	Bishehsari F	-
23561972	Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.	Pancreatology	2013 Mar-Apr	Zhang JG	doi: 10.1016/j.pan.2013.01.001
19443408	Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer.	Anticancer Res	2009 May	Salek C	-
21808062	The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.	J Biol Chem	2011 Sep 23	Banerjee P	doi: 10.1074/jbc.M111.248401
27165221	New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women.	Asian Pac J Cancer Prev	2016	Poorhosseini SM	-
20413844	Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.	Cell Oncol	2010 Jan 1	van Houdt WJ	doi: 10.3233/CLO-2010-0521.
21281602	Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.	Biochem Biophys Res Commun	2011 Mar 4	Koh MS	doi: 10.1016/j.bbrc.2011.01.092
18021740	Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras.	Biochem Biophys Res Commun	2008 Jan 18	Lee JS	-
26413934	A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness.	Int J Cancer	2016 Mar 1	Koh M	doi: 10.1002/ijc.29869
15950068	Effects of HRAS oncogene on cell cycle progression in a cervical cancer-derived cell line.	Arch Med Res	2005 Jul-Aug	Cordova-Alarcon E	-
22433386	H-ras mutation detection in bladder cancer by COLD-PCR analysis and direct sequencing.	Urol Int	2012	Wang AX	doi: 10.1159/000336132
23726918	Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells.	Biochem Biophys Res Commun	2013 Jun 28	Ono M	doi: 10.1016/j.bbrc.2013.05.071
24169525	HRAS mutations in bladder cancer at an early age and the possible association with the Costello Syndrome.	Eur J Hum Genet	2014 Jun	Beukers W	doi: 10.1038/ejhg.2013.251
19029954	Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.	Oncogene	2009 Feb 5	Sui X	doi: 10.1038/onc.2008.423
22865907	Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.	J Clin Endocrinol Metab	2012 Oct	Boichard A	doi: 10.1210/jc.2012-2092
21825040	Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras.	Clin Cancer Res	2011 Oct 1	Eggers JP	doi: 10.1158/1078-0432.CCR-10-2288
20720444	DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma.	Pancreatology	2010	Fasanella KE	doi: 10.1159/000318807
21120662	Changes in expression of oncogenes and TP53 tumour suppressor gene as biomarkers in head and neck cancers.	Eur Arch Otorhinolaryngol	2011 Jul	Szanyi I	doi: 10.1007/s00405-010-1425-6
20108024	Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation.	Cancer Metastasis Rev	2010 Mar	Suda K	doi: 10.1007/s10555-010-9209-4.
18676755	K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.	Clin Cancer Res	2008 Aug 1	Etienne-Grimaldi MC	doi: 10.1158/1078-0432.CCR-07-4906.
21411223	Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.	Cancer Lett	2011 Jul 1	Luwor RB	doi: 10.1016/j.canlet.2011.02.035
18621636	Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.	Clin Colorectal Cancer	2008 May	Freeman DJ	doi: 10.3816/CCC.2008.n.024.
23617461	Role of β4 integrin in HER-3-negative, K-RAS wild-type metastatic colorectal tumors receiving cetuximab.	Future Oncol	2013 Aug	Scartozzi M	doi: 10.2217/fon.13.72
21122380	[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].	Zhonghua Zhong Liu Za Zhi	2010 Sep	Sun LN	-
20375073	Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.	Carcinogenesis	2010 Jul	Kwon O	doi: 10.1093/carcin/bgq071
24696319	RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma.	Clin Cancer Res	2014 Jun 1	Rampias T	doi: 10.1158/1078-0432.CCR-13-2721
19787272	Association of H-ras polymorphisms and susceptibility to sporadic colon cancer.	Int J Oncol	2009 Nov	Catela Ivkovic T	-
27535135	Classical point mutations of RET, BRAF and RAS oncogenes are not shared in papillary and medullary thyroid cancer occurring simultaneously in the same gland.	J Endocrinol Invest	2017 Jan	Ciampi R	doi: 10.1007/s40618-016-0526-5
28202657	Deciphering the RAS/ERK pathway in vivo.	Biochem Soc Trans	2017 Feb 8	Dorard C	doi: 10.1042/BST20160135.
27689252	Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma.	J Clin Endocrinol Metab	2016 Dec	Kakarmath S	-
28864536	Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer.	Eur J Endocrinol	2017 Dec	Song YS	doi: 10.1530/EJE-17-0456

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr11	534286	Missense_Mutation	rs104894228	G13R	0.63	MMR_HSR1
BLCA	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.67	MMR_HSR1
BLCA	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.51	MMR_HSR1
BLCA	chr11	534289	Missense_Mutation	rs104894229	G12S	0.11	MMR_HSR1
BLCA	chr11	534285	Missense_Mutation	rs104894226	G13V	0.37	MMR_HSR1
BLCA	chr11	534226	Missense_Mutation	novel	D33N	0.33	MMR_HSR1
BLCA	chr11	533469	Nonsense_Mutation	novel	S145*	0.15
BLCA	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.42	MMR_HSR1
BLCA	chr11	533763	Splice_Region	novel		0.23
BLCA	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.39	MMR_HSR1
BLCA	chr11	534286	Missense_Mutation	rs104894228	G13R	0.33	MMR_HSR1
BLCA	chr11	532642	Silent	novel	L188L	0.57
BLCA	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.79	MMR_HSR1
BLCA	chr11	534288	Missense_Mutation	rs104894230	G12D	0.23	MMR_HSR1
BLCA	chr11	533345	Intron	novel		0.35
BLCA	chr11	534285	Missense_Mutation	rs104894226	G13D	0.25	MMR_HSR1
BLCA	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.53	MMR_HSR1
BLCA	chr11	533552	Missense_Mutation	NA	K117N	0.34	MMR_HSR1
BLCA	chr11	533312	Intron	novel		0.79
BLCA	chr11	533552	Missense_Mutation	NA	K117N	0.06	MMR_HSR1
BLCA	chr11	533785	Missense_Mutation	NA	E91K	0.37	MMR_HSR1
BLCA	chr11	534288	Missense_Mutation	rs104894230	G12D	0.75	MMR_HSR1
BRCA	chr11	534288	Missense_Mutation	rs104894230	G12D	0.42	MMR_HSR1
BRCA	chr11	534289	Missense_Mutation	rs104894229	G12C	0.54	MMR_HSR1
BRCA	chr11	533450	Splice_Region	novel		0.27
BRCA	chr11	533787	Missense_Mutation	novel	F90C	0.22	MMR_HSR1
BRCA	chr11	532642	Silent	novel	L188L	0.28
BRCA	chr11	534286	Missense_Mutation	rs104894228	G13R	0.41	MMR_HSR1
CESC	chr11	533515	Missense_Mutation	NA	A130T	0.63
CESC	chr11	534330	5'UTR	NA		0.47
COAD	chr11	533280	Intron	novel		0.27
COAD	chr11	534346	5'UTR	rs772063610		0.41
COAD	chr11	533308	Intron	rs764211685		0.35
COAD	chr11	533573	Silent	rs200747280	P110P	0.37
COAD	chr11	533499	Missense_Mutation	novel	R135Q	0.24
COAD	chr11	533834	Silent	rs372223975	T74T	0.41
COAD	chr11	533878	Missense_Mutation	NA	G60S	0.27	MMR_HSR1
COAD	chr11	532700	Missense_Mutation	rs142218590	R169Q	0.36
HNSC	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.26	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.3	MMR_HSR1
HNSC	chr11	534288	Missense_Mutation	rs104894230	G12D	0.41	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.36	MMR_HSR1
HNSC	chr11	534288	Missense_Mutation	rs104894230	G12D	0.45	MMR_HSR1
HNSC	chr11	533550	Missense_Mutation	novel	C118Y	0.32
HNSC	chr11	533456	Frame_Shift_Ins	novel	*Q150Pfs28**	0.16
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.21	MMR_HSR1
HNSC	chr11	533830	Nonsense_Mutation	novel	E76*	0.34	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12C	0.12	MMR_HSR1
HNSC	chr11	534351	5'UTR	novel		0.52
HNSC	chr11	534286	Missense_Mutation	rs104894228	G13R	0.4	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.57	MMR_HSR1
HNSC	chr11	533552	Missense_Mutation	NA	K117N	0.36	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.12	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.43	MMR_HSR1
HNSC	chr11	533873	Missense_Mutation	NA	Q61H	0.29	MMR_HSR1
HNSC	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.27	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.51	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.13	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.13	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.25	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.33	MMR_HSR1
HNSC	chr11	534286	Missense_Mutation	rs104894228	G13R	0.11	MMR_HSR1
HNSC	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.25	MMR_HSR1
HNSC	chr11	534340	5'UTR	rs778954173		0.55
HNSC	chr11	534288	Missense_Mutation	rs104894230	G12A	0.15	MMR_HSR1
HNSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.14	MMR_HSR1
HNSC	chr11	534286	Missense_Mutation	rs104894228	G13R	0.2	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12C	0.64	MMR_HSR1
HNSC	chr11	534286	Missense_Mutation	rs104894228	G13C	0.71	MMR_HSR1
HNSC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.27	MMR_HSR1
LUAD	chr11	533899	Missense_Mutation	novel	L53M	0.08	MMR_HSR1
LUAD	chr11	533462	Missense_Mutation	novel	K147N	0.21
LUAD	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.4	MMR_HSR1
LUSC	chr11	534286	Missense_Mutation	rs104894228	G13R	0.39	MMR_HSR1
LUSC	chr11	534286	Missense_Mutation	rs104894228	G13C	0.15	MMR_HSR1
LUSC	chr11	534286	Missense_Mutation	rs104894228	G13C	0.67	MMR_HSR1
LUSC	chr11	534288	Missense_Mutation	rs104894230	G12V	0.4	MMR_HSR1
LUSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.28	MMR_HSR1
LUSC	chr11	534285	Missense_Mutation	rs104894226	G13V	0.24	MMR_HSR1
LUSC	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.25	MMR_HSR1
LUSC	chr11	533316	Intron	novel		0.29
PAAD	chr11	533503	Missense_Mutation	novel	A134T	0.16
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61L	0.26	MMR_HSR1
PCPG	chr11	534286	Missense_Mutation	rs104894228	G13R	0.33	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.71	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.5	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.44	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.46	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.33	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.49	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.43	MMR_HSR1
PCPG	chr11	534286	Missense_Mutation	rs104894228	G13R	0.59	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.38	MMR_HSR1
PCPG	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.33	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.45	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.49	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.33	MMR_HSR1
PCPG	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.4	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.84	MMR_HSR1
PCPG	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.42	MMR_HSR1
PRAD	chr11	533309	Intron	rs730880457		0.08
PRAD	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.33	MMR_HSR1
PRAD	chr11	533476	Missense_Mutation	NA	E143K	0.15
PRAD	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.28	MMR_HSR1
PRAD	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.13	MMR_HSR1
PRAD	chr11	534269	Silent	rs148380285	A18A	0.1
SKCM	chr11	533312	Intron	novel		0.75
SKCM	chr11	533552	Missense_Mutation	NA	K117N	0.48	MMR_HSR1
SKCM	chr11	534285	Missense_Mutation	rs104894226	G13D	0.27	MMR_HSR1
SKCM	chr11	534286	Missense_Mutation	rs104894228	G13S	0.27	MMR_HSR1
SKCM	chr11	534285	Missense_Mutation	rs104894226	G13D	0.44	MMR_HSR1
SKCM	chr11	533336	Intron	novel		0.23
SKCM	chr11	533352	Intron	rs748089446		0.33
SKCM	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.67	MMR_HSR1
SKCM	chr11	533880	Frame_Shift_Del	novel	*A59Rfs32**	0.38	MMR_HSR1
SKCM	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.4	MMR_HSR1
STAD	chr11	534290	Silent	NA	A11A	0.33
STAD	chr11	532607	Intron	rs375219797		0.4
STAD	chr11	533845	Missense_Mutation	novel	Y71H	0.44	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.42	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.42	MMR_HSR1
THCA	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.38	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.39	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.46	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.28	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.48	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.37	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.4	MMR_HSR1
THCA	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.4	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.39	MMR_HSR1
THCA	chr11	533875	Missense_Mutation	rs28933406	Q61K	0.3	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.42	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.32	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.4	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.55	MMR_HSR1
THCA	chr11	533874	Missense_Mutation	rs121913233	Q61R	0.22	MMR_HSR1
THYM	chr11	533302	Intron	novel		0.36
THYM	chr11	534285	Missense_Mutation	rs104894226	G13V	0.47	MMR_HSR1
THYM	chr11	533552	Missense_Mutation	NA	K117N	0.29	MMR_HSR1
THYM	chr11	534289	Missense_Mutation	rs104894229	G12R	0.29	MMR_HSR1
THYM	chr11	534285	Missense_Mutation	rs104894226	G13V	0.63	MMR_HSR1
THYM	chr11	534284	In_Frame_Ins	novel	G13dup	0.26	MMR_HSR1
THYM	chr11	533553	Missense_Mutation	rs104894227	K117R	0.27	MMR_HSR1
THYM	chr11	533552	Missense_Mutation	NA	K117N	0.55	MMR_HSR1
THYM	chr11	533877	Missense_Mutation	novel	G60V	0.61	MMR_HSR1
THYM	chr11	534286	Missense_Mutation	rs104894228	G13R	0.59	MMR_HSR1
THYM	chr11	533544	Missense_Mutation	novel	L120P	0.39
UCEC	chr11	533881	Missense_Mutation	rs727503093	A59T	0.55	MMR_HSR1
UCEC	chr11	534232	Missense_Mutation	novel	E31K	0.49	MMR_HSR1
UCEC	chr11	534293	Silent	rs752765965	G10G	0.2
UCEC	chr11	534289	Missense_Mutation	rs104894229	G12S	0.53	MMR_HSR1
UCEC	chr11	532607	Intron	rs375219797		0.16
UCEC	chr11	533934	Missense_Mutation	NA	R41Q	0.13	MMR_HSR1
UCEC	chr11	533523	Missense_Mutation	novel	S127Y	0.44
UCEC	chr11	534285	Missense_Mutation	rs104894226	G13D	0.51	MMR_HSR1
UCEC	chr11	532585	Intron	rs771875930		0.41
UCEC	chr11	533881	Missense_Mutation	rs727503093	A59T	0.47	MMR_HSR1
UCEC	chr11	533535	Missense_Mutation	NA	R123H	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.4387	2.9151e-06
BRCA	DEL	0.2463	3.0727e-19
CESC	DEL	0.2949	0.02701
ESCA	AMP	0.1196	0.018342
ESCA	DEL	0.3478	0.0016785
GBM	DEL	0.1837	0.0048476
HNSC	DEL	0.2452	0.00051729
LUAD	DEL	0.1919	0.00044751
LUSC	DEL	0.3872	4.3974e-14
OV	DEL	0.5682	4.8003e-42
PAAD	DEL	0.1087	0.022808
PCPG	AMP	0.0309	0.23196
PCPG	DEL	0.3272	0.00064285
TGCT	DEL	0.56	0.21504
UCEC	DEL	0.1763	2.4803e-07

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.039	Kaplan-Meier Survival Analysis
MESO	0.0021	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.00033	Kaplan-Meier Survival Analysis
COAD	0.0082	Kaplan-Meier Survival Analysis
PAAD	0.0089	Kaplan-Meier Survival Analysis
UCEC	0.004	Kaplan-Meier Survival Analysis
GBM	0.0039	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
THCA	0.037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000174775 (Gene tree)
Gene ID: 3265
Gene Symbol: HRAS
Alias: HRAS1
Full Name: HRas proto-oncogene, GTPase
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 5,046 bases
Position: chr11:532,242-537,287
Accession: 5173
Summary: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000380722	MMR_HSR1	PF01926.23	7.6e-05	1	1
ENSP00000388246	MMR_HSR1	PF01926.23	7.6e-05	1	1
ENSP00000309845	MMR_HSR1	PF01926.23	9.8e-05	1	1
ENSP00000380723	MMR_HSR1	PF01926.23	9.8e-05	1	1
ENSP00000407586	MMR_HSR1	PF01926.23	9.8e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31061957	Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.	Hepatol Commun	2019 Feb 25	Watanabe K	doi: 10.1002/hep4.1327
3012774	Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter.	Science	1986 Jun 13	Ishii S	-
7666541	An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.	J Virol	1995 Oct	Berlioz C	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478324	HRAS-208	631	-	-	- (aa)	-	-
ENST00000482021	HRAS-210	167	-	-	- (aa)	-	-
ENST00000493230	HRAS-211	1114	-	ENSP00000434023	170 (aa)	-	P01112
ENST00000462734	HRAS-206	627	-	-	- (aa)	-	-
ENST00000397594	HRAS-202	1099	-	ENSP00000380722	170 (aa)	-	P01112
ENST00000468682	HRAS-207	749	-	-	- (aa)	-	-
ENST00000397596	HRAS-203	1100	-	ENSP00000380723	189 (aa)	-	P01112
ENST00000311189	HRAS-201	894	-	ENSP00000309845	189 (aa)	-	P01112
ENST00000451590	HRAS-205	1151	-	ENSP00000407586	189 (aa)	-	P01112
ENST00000479482	HRAS-209	485	-	-	- (aa)	-	-
ENST00000417302	HRAS-204	1233	-	ENSP00000388246	170 (aa)	-	P01112

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa01522	Endocrine resistance	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04068	FoxO signaling pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04137	Mitophagy - animal	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04144	Endocytosis	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04210	Apoptosis	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04213	Longevity regulating pathway - multiple species	KEGG
hsa04218	Cellular senescence	KEGG
hsa04360	Axon guidance	KEGG
hsa04370	VEGF signaling pathway	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04540	Gap junction	KEGG
hsa04550	Signaling pathways regulating pluripotency of stem cells	KEGG
hsa04625	C-type lectin receptor signaling pathway	KEGG
hsa04630	JAK-STAT signaling pathway	KEGG
hsa04650	Natural killer cell mediated cytotoxicity	KEGG
hsa04660	T cell receptor signaling pathway	KEGG
hsa04662	B cell receptor signaling pathway	KEGG
hsa04664	Fc epsilon RI signaling pathway	KEGG
hsa04714	Thermogenesis	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04725	Cholinergic synapse	KEGG
hsa04726	Serotonergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04917	Prolactin signaling pathway	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04926	Relaxin signaling pathway	KEGG
hsa04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
hsa05034	Alcoholism	KEGG
hsa05160	Hepatitis C	KEGG
hsa05161	Hepatitis B	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG
hsa05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05210	Colorectal cancer	KEGG
hsa05211	Renal cell carcinoma	KEGG
hsa05213	Endometrial cancer	KEGG
hsa05214	Glioma	KEGG
hsa05215	Prostate cancer	KEGG
hsa05216	Thyroid cancer	KEGG
hsa05218	Melanoma	KEGG
hsa05219	Bladder cancer	KEGG
hsa05220	Chronic myeloid leukemia	KEGG
hsa05221	Acute myeloid leukemia	KEGG
hsa05223	Non-small cell lung cancer	KEGG
hsa05224	Breast cancer	KEGG
hsa05225	Hepatocellular carcinoma	KEGG
hsa05226	Gastric cancer	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG
hsa05231	Choline metabolism in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174775's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174775	HRAS	100	95.767	ENSAPOG00000023684	hrasb	100	95.767	Acanthochromis_polyacanthus
ENSG00000174775	HRAS	100	96.825	ENSAMEG00000010515	HRAS	75	96.825	Ailuropoda_melanoleuca
ENSG00000174775	HRAS	100	95.767	ENSACIG00000000699	hrasb	100	95.767	Amphilophus_citrinellus
ENSG00000174775	HRAS	100	95.767	ENSAOCG00000011843	hrasb	100	95.767	Amphiprion_ocellaris
ENSG00000174775	HRAS	100	95.767	ENSAPEG00000009546	hrasb	100	95.767	Amphiprion_percula
ENSG00000174775	HRAS	100	95.767	ENSATEG00000020001	hrasb	100	95.767	Anabas_testudineus
ENSG00000174775	HRAS	89	98.675	ENSAPLG00000012248	HRAS	100	98.780	Anas_platyrhynchos
ENSG00000174775	HRAS	100	97.354	ENSACAG00000014920	HRAS	100	97.354	Anolis_carolinensis
ENSG00000174775	HRAS	100	100.000	ENSANAG00000034201	HRAS	100	100.000	Aotus_nancymaae
ENSG00000174775	HRAS	100	95.238	ENSACLG00000001181	hrasb	100	95.238	Astatotilapia_calliptera
ENSG00000174775	HRAS	100	94.180	ENSAMXG00000033907	hrasb	100	94.180	Astyanax_mexicanus
ENSG00000174775	HRAS	100	95.238	ENSAMXG00000035885	hrasa	100	95.238	Astyanax_mexicanus
ENSG00000174775	HRAS	99	98.225	ENSBTAG00000046644	HRAS	99	98.225	Bos_taurus
ENSG00000174775	HRAS	96	76.796	WBGene00002335	let-60	98	76.796	Caenorhabditis_elegans
ENSG00000174775	HRAS	100	100.000	ENSCJAG00000012199	HRAS	100	100.000	Callithrix_jacchus
ENSG00000174775	HRAS	99	92.899	ENSCAFG00000031029	HRAS	60	100.000	Canis_familiaris
ENSG00000174775	HRAS	99	99.408	ENSCAFG00020007059	HRAS	99	99.408	Canis_lupus_dingo
ENSG00000174775	HRAS	99	98.225	ENSCHIG00000004808	HRAS	99	98.225	Capra_hircus
ENSG00000174775	HRAS	100	100.000	ENSTSYG00000003745	HRAS	100	100.000	Carlito_syrichta
ENSG00000174775	HRAS	100	99.471	ENSCAPG00000000745	HRAS	100	99.471	Cavia_aperea
ENSG00000174775	HRAS	100	99.471	ENSCPOG00000000101	HRAS	100	99.471	Cavia_porcellus
ENSG00000174775	HRAS	100	100.000	ENSCCAG00000031453	HRAS	100	100.000	Cebus_capucinus
ENSG00000174775	HRAS	100	100.000	ENSCATG00000031194	HRAS	100	100.000	Cercocebus_atys
ENSG00000174775	HRAS	100	99.471	ENSCLAG00000002823	HRAS	100	99.471	Chinchilla_lanigera
ENSG00000174775	HRAS	100	100.000	ENSCSAG00000011033	HRAS	100	100.000	Chlorocebus_sabaeus
ENSG00000174775	HRAS	100	97.354	ENSCPBG00000013941	-	100	97.354	Chrysemys_picta_bellii
ENSG00000174775	HRAS	100	100.000	ENSCANG00000017827	HRAS	100	100.000	Colobus_angolensis_palliatus
ENSG00000174775	HRAS	100	100.000	ENSCGRG00001018735	Hras	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000174775	HRAS	100	100.000	ENSCGRG00000010918	Hras	100	100.000	Cricetulus_griseus_crigri
ENSG00000174775	HRAS	100	95.767	ENSCSEG00000007927	hrasb	100	95.767	Cynoglossus_semilaevis
ENSG00000174775	HRAS	100	95.238	ENSCVAG00000008670	hrasb	100	95.238	Cyprinodon_variegatus
ENSG00000174775	HRAS	99	80.851	ENSDARG00000013161	zgc:55558	89	89.222	Danio_rerio
ENSG00000174775	HRAS	100	94.180	ENSDARG00000005651	hrasb	100	97.222	Danio_rerio
ENSG00000174775	HRAS	100	94.709	ENSDARG00000098497	hrasa	100	94.709	Danio_rerio
ENSG00000174775	HRAS	99	94.681	ENSDNOG00000015293	HRAS	99	94.681	Dasypus_novemcinctus
ENSG00000174775	HRAS	100	100.000	ENSDORG00000028079	Hras	100	100.000	Dipodomys_ordii
ENSG00000174775	HRAS	89	86.093	FBgn0003205	Ras85D	96	81.215	Drosophila_melanogaster
ENSG00000174775	HRAS	100	97.354	ENSETEG00000019899	HRAS	100	97.354	Echinops_telfairi
ENSG00000174775	HRAS	100	90.476	ENSEBUG00000004670	hrasb	100	90.476	Eptatretus_burgeri
ENSG00000174775	HRAS	100	97.884	ENSECAG00000008473	HRAS	100	97.884	Equus_caballus
ENSG00000174775	HRAS	91	96.774	ENSEEUG00000014548	HRAS	90	96.774	Erinaceus_europaeus
ENSG00000174775	HRAS	100	95.767	ENSELUG00000004712	HRAS	100	95.767	Esox_lucius
ENSG00000174775	HRAS	99	99.408	ENSFCAG00000002990	HRAS	99	99.408	Felis_catus
ENSG00000174775	HRAS	100	97.884	ENSFALG00000012145	HRAS	100	97.884	Ficedula_albicollis
ENSG00000174775	HRAS	100	100.000	ENSFDAG00000006760	HRAS	100	100.000	Fukomys_damarensis
ENSG00000174775	HRAS	100	94.709	ENSFHEG00000010055	hrasb	100	94.709	Fundulus_heteroclitus
ENSG00000174775	HRAS	94	96.629	ENSGMOG00000010196	hrasb	96	96.629	Gadus_morhua
ENSG00000174775	HRAS	100	97.884	ENSGALG00000029260	H-RAS	100	97.884	Gallus_gallus
ENSG00000174775	HRAS	100	95.767	ENSGAFG00000021814	hrasb	100	95.767	Gambusia_affinis
ENSG00000174775	HRAS	100	95.767	ENSGACG00000011340	hrasb	100	95.767	Gasterosteus_aculeatus
ENSG00000174775	HRAS	100	97.354	ENSGAGG00000019886	-	100	97.354	Gopherus_agassizii
ENSG00000174775	HRAS	100	99.471	ENSGGOG00000015438	HRAS	100	99.471	Gorilla_gorilla
ENSG00000174775	HRAS	100	95.238	ENSHBUG00000011998	hrasb	100	95.238	Haplochromis_burtoni
ENSG00000174775	HRAS	100	99.471	ENSHGLG00000004508	HRAS	100	99.471	Heterocephalus_glaber_female
ENSG00000174775	HRAS	100	99.471	ENSHGLG00100012888	HRAS	100	99.471	Heterocephalus_glaber_male
ENSG00000174775	HRAS	100	95.238	ENSIPUG00000006053	hras	100	95.238	Ictalurus_punctatus
ENSG00000174775	HRAS	100	94.180	ENSIPUG00000022502	hrasb	100	94.180	Ictalurus_punctatus
ENSG00000174775	HRAS	100	100.000	ENSSTOG00000021206	HRAS	100	100.000	Ictidomys_tridecemlineatus
ENSG00000174775	HRAS	100	99.471	ENSJJAG00000022529	-	100	99.471	Jaculus_jaculus
ENSG00000174775	HRAS	100	90.476	ENSJJAG00000011743	-	100	90.476	Jaculus_jaculus
ENSG00000174775	HRAS	100	95.767	ENSKMAG00000001922	Ha-ras	100	95.767	Kryptolebias_marmoratus
ENSG00000174775	HRAS	100	95.767	ENSLBEG00000001905	hrasb	100	95.767	Labrus_bergylta
ENSG00000174775	HRAS	100	95.767	ENSLACG00000018427	HRAS	100	95.767	Latimeria_chalumnae
ENSG00000174775	HRAS	100	95.767	ENSLOCG00000000684	hrasb	100	95.767	Lepisosteus_oculatus
ENSG00000174775	HRAS	100	100.000	ENSMFAG00000039003	HRAS	100	100.000	Macaca_fascicularis
ENSG00000174775	HRAS	100	100.000	ENSMMUG00000021659	HRAS	100	100.000	Macaca_mulatta
ENSG00000174775	HRAS	100	100.000	ENSMNEG00000039358	HRAS	100	100.000	Macaca_nemestrina
ENSG00000174775	HRAS	100	100.000	ENSMLEG00000042070	HRAS	100	100.000	Mandrillus_leucophaeus
ENSG00000174775	HRAS	100	95.767	ENSMAMG00000004359	hrasb	100	95.767	Mastacembelus_armatus
ENSG00000174775	HRAS	100	95.238	ENSMZEG00005017583	hrasb	100	95.238	Maylandia_zebra
ENSG00000174775	HRAS	100	100.000	ENSMAUG00000020006	Hras	100	100.000	Mesocricetus_auratus
ENSG00000174775	HRAS	100	99.471	ENSMICG00000006472	HRAS	100	99.471	Microcebus_murinus
ENSG00000174775	HRAS	100	100.000	ENSMOCG00000000744	Hras	100	100.000	Microtus_ochrogaster
ENSG00000174775	HRAS	88	98.000	ENSMODG00000016580	HRAS	71	98.000	Monodelphis_domestica
ENSG00000174775	HRAS	100	95.767	ENSMALG00000011273	hrasb	100	95.767	Monopterus_albus
ENSG00000174775	HRAS	100	99.471	MGP_CAROLIEiJ_G0030681	Hras	100	99.471	Mus_caroli
ENSG00000174775	HRAS	100	100.000	ENSMUSG00000025499	Hras	100	100.000	Mus_musculus
ENSG00000174775	HRAS	100	99.471	MGP_PahariEiJ_G0013880	Hras	100	99.471	Mus_pahari
ENSG00000174775	HRAS	100	89.418	MGP_SPRETEiJ_G0031792	-	100	89.418	Mus_spretus
ENSG00000174775	HRAS	100	100.000	ENSNGAG00000022044	Hras	100	100.000	Nannospalax_galili
ENSG00000174775	HRAS	100	100.000	ENSNLEG00000008300	HRAS	100	100.000	Nomascus_leucogenys
ENSG00000174775	HRAS	100	99.471	ENSODEG00000015703	HRAS	100	99.471	Octodon_degus
ENSG00000174775	HRAS	100	95.767	ENSONIG00000014560	hrasb	100	95.767	Oreochromis_niloticus
ENSG00000174775	HRAS	96	85.976	ENSORLG00000024443	zgc:55558	96	84.916	Oryzias_latipes
ENSG00000174775	HRAS	100	95.238	ENSORLG00000018912	hrasb	100	95.238	Oryzias_latipes
ENSG00000174775	HRAS	89	91.391	ENSORLG00020013690	zgc:55558	96	84.916	Oryzias_latipes_hni
ENSG00000174775	HRAS	100	95.238	ENSORLG00020008129	hras	100	95.238	Oryzias_latipes_hni
ENSG00000174775	HRAS	89	91.391	ENSORLG00015003353	zgc:55558	96	84.916	Oryzias_latipes_hsok
ENSG00000174775	HRAS	100	94.180	ENSOMEG00000018719	hrasb	100	94.180	Oryzias_melastigma
ENSG00000174775	HRAS	89	92.053	ENSOMEG00000016685	zgc:55558	96	85.475	Oryzias_melastigma
ENSG00000174775	HRAS	100	98.413	ENSOGAG00000024846	HRAS	100	98.413	Otolemur_garnettii
ENSG00000174775	HRAS	88	99.333	ENSOARG00000007365	HRAS	99	99.333	Ovis_aries
ENSG00000174775	HRAS	100	100.000	ENSPPAG00000028620	HRAS	100	100.000	Pan_paniscus
ENSG00000174775	HRAS	88	100.000	ENSPPRG00000008185	HRAS	88	100.000	Panthera_pardus
ENSG00000174775	HRAS	78	100.000	ENSPTIG00000006043	HRAS	100	100.000	Panthera_tigris_altaica
ENSG00000174775	HRAS	100	100.000	ENSPTRG00000034469	HRAS	100	100.000	Pan_troglodytes
ENSG00000174775	HRAS	100	100.000	ENSPANG00000008022	-	100	100.000	Papio_anubis
ENSG00000174775	HRAS	100	99.471	ENSPANG00000016633	-	100	99.471	Papio_anubis
ENSG00000174775	HRAS	100	94.709	ENSPKIG00000000303	HRAS	100	94.709	Paramormyrops_kingsleyae
ENSG00000174775	HRAS	99	94.149	ENSPKIG00000013507	hrasb	100	93.651	Paramormyrops_kingsleyae
ENSG00000174775	HRAS	100	96.825	ENSPSIG00000014690	HRAS	99	96.825	Pelodiscus_sinensis
ENSG00000174775	HRAS	78	92.481	ENSPMGG00000014517	zgc:55558	94	92.481	Periophthalmus_magnuspinnatus
ENSG00000174775	HRAS	96	96.133	ENSPMGG00000005812	HRAS	88	96.133	Periophthalmus_magnuspinnatus
ENSG00000174775	HRAS	100	100.000	ENSPEMG00000013973	-	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000174775	HRAS	100	89.418	ENSPMAG00000004548	hrasb	98	89.418	Petromyzon_marinus
ENSG00000174775	HRAS	100	96.825	ENSPCIG00000008359	HRAS	100	96.825	Phascolarctos_cinereus
ENSG00000174775	HRAS	100	95.767	ENSPFOG00000002595	hrasb	100	95.767	Poecilia_formosa
ENSG00000174775	HRAS	100	94.709	ENSPLAG00000003379	hrasb	100	94.709	Poecilia_latipinna
ENSG00000174775	HRAS	100	95.767	ENSPMEG00000020891	hrasb	100	95.767	Poecilia_mexicana
ENSG00000174775	HRAS	100	95.767	ENSPREG00000019341	hrasb	100	95.767	Poecilia_reticulata
ENSG00000174775	HRAS	100	100.000	ENSPPYG00000002868	HRAS	100	100.000	Pongo_abelii
ENSG00000174775	HRAS	100	99.471	ENSPCOG00000021838	HRAS	100	99.471	Propithecus_coquereli
ENSG00000174775	HRAS	100	95.238	ENSPNYG00000015124	hrasb	100	95.238	Pundamilia_nyererei
ENSG00000174775	HRAS	100	95.767	ENSPNAG00000014085	hrasa	100	95.767	Pygocentrus_nattereri
ENSG00000174775	HRAS	100	94.180	ENSPNAG00000000584	hrasb	100	94.180	Pygocentrus_nattereri
ENSG00000174775	HRAS	100	100.000	ENSRNOG00000016611	Hras	100	100.000	Rattus_norvegicus
ENSG00000174775	HRAS	100	100.000	ENSRBIG00000034835	HRAS	100	100.000	Rhinopithecus_bieti
ENSG00000174775	HRAS	100	100.000	ENSRROG00000041325	HRAS	100	100.000	Rhinopithecus_roxellana
ENSG00000174775	HRAS	100	100.000	ENSSBOG00000023272	HRAS	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000174775	HRAS	97	55.080	ENSSHAG00000004318	-	81	58.537	Sarcophilus_harrisii
ENSG00000174775	HRAS	100	94.180	ENSSFOG00015003051	hrasb	100	94.180	Scleropages_formosus
ENSG00000174775	HRAS	100	94.180	ENSSFOG00015011157	-	100	94.180	Scleropages_formosus
ENSG00000174775	HRAS	100	95.767	ENSSMAG00000008745	hrasb	100	95.767	Scophthalmus_maximus
ENSG00000174775	HRAS	100	95.767	ENSSDUG00000019086	hrasb	100	95.767	Seriola_dumerili
ENSG00000174775	HRAS	100	95.767	ENSSLDG00000012627	hrasb	100	95.767	Seriola_lalandi_dorsalis
ENSG00000174775	HRAS	100	97.354	ENSSPUG00000005243	HRAS	100	97.354	Sphenodon_punctatus
ENSG00000174775	HRAS	100	95.238	ENSSPAG00000007357	hrasb	100	95.238	Stegastes_partitus
ENSG00000174775	HRAS	100	97.354	ENSSSCG00000031513	HRAS	100	97.354	Sus_scrofa
ENSG00000174775	HRAS	100	97.884	ENSTGUG00000009877	HRAS	100	97.884	Taeniopygia_guttata
ENSG00000174775	HRAS	100	94.709	ENSTRUG00000024825	hrasb	100	94.709	Takifugu_rubripes
ENSG00000174775	HRAS	100	94.709	ENSTNIG00000011385	hrasb	100	94.709	Tetraodon_nigroviridis
ENSG00000174775	HRAS	100	96.296	ENSTTRG00000011120	HRAS	100	96.296	Tursiops_truncatus
ENSG00000174775	HRAS	99	99.408	ENSUAMG00000027527	-	99	99.408	Ursus_americanus
ENSG00000174775	HRAS	99	98.817	ENSUMAG00000005506	-	99	98.817	Ursus_maritimus
ENSG00000174775	HRAS	100	97.884	ENSVVUG00000017151	HRAS	100	97.884	Vulpes_vulpes
ENSG00000174775	HRAS	100	96.296	ENSXETG00000006040	hras	100	96.296	Xenopus_tropicalis
ENSG00000174775	HRAS	94	97.740	ENSXCOG00000020608	hrasb	94	94.656	Xiphophorus_couchianus
ENSG00000174775	HRAS	100	95.767	ENSXMAG00000015132	hrasb	100	95.767	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0000165	MAPK cascade	-	TAS	Process
GO:0001934	positive regulation of protein phosphorylation	22065586.	IDA	Process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0003924	GTPase activity	9178006.	IDA	Function
GO:0003924	GTPase activity	9230043.	IMP	Function
GO:0005515	protein binding	2122974.8332187.8670882.9144171.9447984.9488663.9690470.10369681.10608844.11022048.11335720.11598133.11857081.11980706.12620389.12628188.14500341.14724641.15507210.15886098.16316996.16698549.17084389.17540175.18073111.18273062.18454158.18596699.19063885.19141281.19222999.19696784.20080631.20133692.20133694.20178605.20936779.22020336.22169110.24441586.24929361.25241761.25684575.26165597.	IPI	Function
GO:0005525	GTP binding	14500341.17260967.	IDA	Function
GO:0005525	GTP binding	9230043.	IMP	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	10842192.	TAS	Component
GO:0005794	Golgi apparatus	14500341.21968647.	IDA	Component
GO:0005886	plasma membrane	14500341.17724343.21968647.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006897	endocytosis	-	IEA	Process
GO:0006935	chemotaxis	10848592.	TAS	Process
GO:0007050	cell cycle arrest	9054499.	IDA	Process
GO:0007050	cell cycle arrest	9765203.	IMP	Process
GO:0007093	mitotic cell cycle checkpoint	9054499.	IDA	Process
GO:0007165	signal transduction	8607982.	NAS	Process
GO:0007166	cell surface receptor signaling pathway	9020890.	TAS	Process
GO:0007265	Ras protein signal transduction	23027131.	IDA	Process
GO:0007265	Ras protein signal transduction	-	TAS	Process
GO:0008022	protein C-terminus binding	9219684.	IPI	Function
GO:0008283	cell proliferation	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	9765203.	IDA	Process
GO:0008285	negative regulation of cell proliferation	9054499.	IDA	Process
GO:0009887	animal organ morphogenesis	10848592.	TAS	Process
GO:0010629	negative regulation of gene expression	23027131.	IDA	Process
GO:0010863	positive regulation of phospholipase C activity	11022048.	IDA	Process
GO:0019003	GDP binding	8142349.9230043.	IMP	Function
GO:0030335	positive regulation of cell migration	23027131.	IDA	Process
GO:0032729	positive regulation of interferon-gamma production	-	IEA	Process
GO:0034260	negative regulation of GTPase activity	23027131.	IDA	Process
GO:0035900	response to isolation stress	-	IEA	Process
GO:0042088	T-helper 1 type immune response	-	IEA	Process
GO:0042832	defense response to protozoan	-	IEA	Process
GO:0043406	positive regulation of MAP kinase activity	23027131.	IDA	Process
GO:0043410	positive regulation of MAPK cascade	9765203.	IDA	Process
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	Process
GO:0043547	positive regulation of GTPase activity	23027131.	IDA	Process
GO:0045740	positive regulation of DNA replication	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	22065586.23027131.	IDA	Process
GO:0046330	positive regulation of JNK cascade	22065586.	IDA	Process
GO:0046579	positive regulation of Ras protein signal transduction	-	IEA	Process
GO:0048013	ephrin receptor signaling pathway	-	TAS	Process
GO:0048169	regulation of long-term neuronal synaptic plasticity	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050679	positive regulation of epithelial cell proliferation	20154697.	IMP	Process
GO:0050852	T cell receptor signaling pathway	-	IEA	Process
GO:0051291	protein heterooligomerization	-	IEA	Process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	22065586.	IDA	Process
GO:0071480	cellular response to gamma radiation	16213212.	IDA	Process
GO:0090303	positive regulation of wound healing	23027131.	IDA	Process
GO:0090314	positive regulation of protein targeting to membrane	11022048.	IMP	Process
GO:0090398	cellular senescence	9054499.	IDA	Process
GO:0097193	intrinsic apoptotic signaling pathway	-	IEA	Process
GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	12202034.	EXP	Process
GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	12202034.	IDA	Process
GO:0098978	glutamatergic synapse	12202034.	EXP	Component
GO:0098978	glutamatergic synapse	12202034.	IDA	Component
GO:1900029	positive regulation of ruffle assembly	23027131.	IDA	Process
GO:2000251	positive regulation of actin cytoskeleton reorganization	23027131.	IDA	Process
GO:2000630	positive regulation of miRNA metabolic process	23027131.	IDA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

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Expression

Transcripts

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Pathway

PPI

Ortholog

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.