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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23240926Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.Thyroid2013 JanCiampi Rdoi: 10.1089/thy.2012.0207
26522772H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases.J Pediatr Urol2016 AprCastillo-Martin Mdoi: 10.1016/j.jpurol.2015.08.020
21330833Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.Int J Gynecol Cancer2011 JanWegman Pdoi: 10.1097/IGC.0b013e3182049924.
27074591Impact of SNPs on CpG Islands in the MYC and HRAS oncogenes and in a wide variety of tumor suppressor genes: A multi-cancer approach.Cell Cycle2016 Jun 17Samy MDdoi: 10.1080/15384101.2016.1164360.
28371260Phenotypic spectrum of Costello syndrome individuals harboring the rare HRAS mutation p.Gly13Asp.Am J Med Genet A2017 MayBertola Ddoi: 10.1002/ajmg.a.38178
22427690Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature.J Cell Sci2012 Jul 1Solomon Hdoi: 10.1242/jcs.099663
22982396Oncogene Ras/phosphatidylinositol 3-kinase signaling targets histone H3 acetylation at lysine 56.J Biol Chem2012 Nov 30Liu Ydoi: 10.1074/jbc.M112.367847
19254697Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.Biochem Biophys Res Commun2009 Apr 17Wilder PJdoi: 10.1016/j.bbrc.2009.02.126
17374253[K-ras mutation analysis in ovarian serous borderline and malignant tumors].Zhonghua Bing Li Xue Za Zhi2006 DecMa L-
23028055Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions.J Immunol2012 Nov 1Vernitsky Hdoi: 10.4049/jimmunol.1200019
22573884Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.Mol Biol Cell2012 JulSchmees Cdoi: 10.1091/mbc.E11-04-0317
16286246Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.Cancer Cell2005 NovLim KH-
19101897Mutations of RAS gene family in specimens of bladder cancer.Urol J2008 FallKarimianpour N-
17096025The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.Cell Death Differ2007 MayShapira S-
21665306In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.Radiother Oncol2011 OctMyllynen Ldoi: 10.1016/j.radonc.2011.05.046
15816642Persistence of K-ras mutations in plasma after colorectal tumor resection.Anticancer Res2005 Jan-FebLindforss U-
19140325[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas].Mol Biol (Mosk)2008 Nov-DecNemtsova MN-
22589270A comprehensive survey of Ras mutations in cancer.Cancer Res2012 May 15Prior IAdoi: 10.1158/0008-5472.CAN-11-2612.
16738062p19ras brings a new twist to the regulation of p73 by Mdm2.Sci STKE2006 May 30Harms KL-
23583409p53 Attenuates the oncogenic Ras-induced epithelial-mesenchymal transition in human mammary epithelial cells.Biochem Biophys Res Commun2013 May 10Zhang Jdoi: 10.1016/j.bbrc.2013.03.124
21473856RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage.Biochem Biophys Res Commun2011 Apr 29Park SHdoi: 10.1016/j.bbrc.2011.03.139
18465119Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.Arch Toxicol2008 OctJin Mdoi: 10.1007/s00204-008-0293-y
19855428Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.Oncogene2009 Dec 17Aylon Ydoi: 10.1038/onc.2009.270
26620726MicroRNAs: Modulators of the Ras Oncogenes in Oral Cancer.J Cell Physiol2016 JulMurugan AKdoi: 10.1002/jcp.25269
26560143Absolute Quantification of Endogenous Ras Isoform Abundance.PLoS One2015 Nov 11Mageean CJdoi: 10.1371/journal.pone.0142674
24908601Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma.Oral Surg Oral Med Oral Pathol Oral Radiol2014 JulChang YSdoi: 10.1016/j.oooo.2014.03.016
26568031Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.Biochemistry2015 Dec 15Najumudeen AKdoi: 10.1021/acs.biochem.5b00724
27913610Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome.Eur J Endocrinol2017 FebLi Y-
30655611WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.Nat Commun2019 Jan 17Jeong WJdoi: 10.1038/s41467-018-08230-6.
22490849[Association between H-ras and L-myc gene polymorphisms and susceptibility to colorectal cancer].Zhonghua Zhong Liu Za Zhi2012 JanNi Q-
28259994Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.Int J Mol Med2017 AprBai Sdoi: 10.3892/ijmm.2017.2903
16857742Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells.Mol Pharmacol2006 OctYeh CW-
22707223Methylation pattern of oncogene HRAS gene promoter region and its clinical relevance to urocystic tumorigenesis.Mol Biol Rep2012 AugSun XFdoi: 10.1007/s11033-012-1696-7
18783589Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.BMC Cancer2008 Sep 10Zhang Ydoi: 10.1186/1471-2407-8-256.
23264394Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.J Clin Endocrinol Metab2013 FebAgrawal Ndoi: 10.1210/jc.2012-2703
21080251Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.Tumour Biol2011 AprChen HCdoi: 10.1007/s13277-010-0129-2
21514184HRAS T81C polymorphism modulates risk of urinary bladder cancer and predicts advanced tumors in ethnic Kashmiri population.Urol Oncol2013 MayPandith AAdoi: 10.1016/j.urolonc.2011.03.004
24648519Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.J Biol Chem2014 May 16Wang Ydoi: 10.1074/jbc.M113.527671
11788888Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.Int J Oncol2002 FebSchondorf T-
18655729Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?BMC Cancer2008 Jul 27Kristensen ATdoi: 10.1186/1471-2407-8-213.
20848283The role of K-ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.Cancer Chemother Pharmacol2011 FebSahu RPdoi: 10.1007/s00280-010-1463-1
23150177Lack of mutational events of RAS genes in sporadic thyroid cancer but high risk associated with HRAS T81C single nucleotide polymorphism (case-control study).Tumour Biol2013 FebKhan MSdoi: 10.1007/s13277-012-0577-y
18296105Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: results from the Netherlands Cohort Study.Mutat Res2008 Mar 29Weijenberg MPdoi: 10.1016/j.mrgentox.2007.12.008
26799184Comparison of liver oncogenic potential among human RAS isoforms.Oncotarget2016 Feb 9Chung SIdoi: 10.18632/oncotarget.6931.
18677112Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.Cell Cycle2008 AugPark Y-
21826673Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.J Surg Oncol2012 JanNa KYdoi: 10.1002/jso.22064
237225514-Hydroxytamoxifen induces autophagic death through K-Ras degradation.Cancer Res2013 Jul 15Kohli Ldoi: 10.1158/0008-5472.CAN-12-3765
21336946Limited evidence supported the association of HRAS1 polymorphism with breast cancer risk.Breast Cancer Res Treat2011 JulZhang Xdoi: 10.1007/s10549-011-1407-4
15638373Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.Rocz Akad Med Bialymst2004Okulczyk B-
23168708Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.Indian J Med Res2012 OctSaxena A-
22324744DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.Eur J Clin Invest2012 JulXu XMdoi: 10.1111/j.1365-2362.2011.02641.x
20038817Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.Cancer Biol Ther2009 DecNavaraj A-
21221763Current evidence on the relationship between HRAS1 polymorphism and breast cancer risk: a meta-analysis.Breast Cancer Res Treat2011 JulZhang Cdoi: 10.1007/s10549-011-1344-2
16384911RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.FASEB J2006 MarMei FC-
17018607Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.Cancer Res2006 Oct 1Datta D-
26969876Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients.Cancer2016 May 1Song YSdoi: 10.1002/cncr.29934
16760302Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.Ann Oncol2006 JunBishehsari F-
23561972Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.Pancreatology2013 Mar-AprZhang JGdoi: 10.1016/j.pan.2013.01.001
19443408Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer.Anticancer Res2009 MaySalek C-
21808062The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.J Biol Chem2011 Sep 23Banerjee Pdoi: 10.1074/jbc.M111.248401
27165221New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women.Asian Pac J Cancer Prev2016Poorhosseini SM-
20413844Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.Cell Oncol2010 Jan 1van Houdt WJdoi: 10.3233/CLO-2010-0521.
21281602Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.Biochem Biophys Res Commun2011 Mar 4Koh MSdoi: 10.1016/j.bbrc.2011.01.092
18021740Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras.Biochem Biophys Res Commun2008 Jan 18Lee JS-
26413934A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness.Int J Cancer2016 Mar 1Koh Mdoi: 10.1002/ijc.29869
15950068Effects of HRAS oncogene on cell cycle progression in a cervical cancer-derived cell line.Arch Med Res2005 Jul-AugCordova-Alarcon E-
22433386H-ras mutation detection in bladder cancer by COLD-PCR analysis and direct sequencing.Urol Int2012Wang AXdoi: 10.1159/000336132
23726918Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells.Biochem Biophys Res Commun2013 Jun 28Ono Mdoi: 10.1016/j.bbrc.2013.05.071
24169525HRAS mutations in bladder cancer at an early age and the possible association with the Costello Syndrome.Eur J Hum Genet2014 JunBeukers Wdoi: 10.1038/ejhg.2013.251
19029954Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.Oncogene2009 Feb 5Sui Xdoi: 10.1038/onc.2008.423
22865907Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.J Clin Endocrinol Metab2012 OctBoichard Adoi: 10.1210/jc.2012-2092
21825040Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras.Clin Cancer Res2011 Oct 1Eggers JPdoi: 10.1158/1078-0432.CCR-10-2288
20720444DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma.Pancreatology2010Fasanella KEdoi: 10.1159/000318807
21120662Changes in expression of oncogenes and TP53 tumour suppressor gene as biomarkers in head and neck cancers.Eur Arch Otorhinolaryngol2011 JulSzanyi Idoi: 10.1007/s00405-010-1425-6
20108024Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation.Cancer Metastasis Rev2010 MarSuda Kdoi: 10.1007/s10555-010-9209-4.
18676755K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.Clin Cancer Res2008 Aug 1Etienne-Grimaldi MCdoi: 10.1158/1078-0432.CCR-07-4906.
21411223Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.Cancer Lett2011 Jul 1Luwor RBdoi: 10.1016/j.canlet.2011.02.035
18621636Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.Clin Colorectal Cancer2008 MayFreeman DJdoi: 10.3816/CCC.2008.n.024.
23617461Role of β4 integrin in HER-3-negative, K-RAS wild-type metastatic colorectal tumors receiving cetuximab.Future Oncol2013 AugScartozzi Mdoi: 10.2217/fon.13.72
21122380[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].Zhonghua Zhong Liu Za Zhi2010 SepSun LN-
20375073Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.Carcinogenesis2010 JulKwon Odoi: 10.1093/carcin/bgq071
24696319RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma.Clin Cancer Res2014 Jun 1Rampias Tdoi: 10.1158/1078-0432.CCR-13-2721
19787272Association of H-ras polymorphisms and susceptibility to sporadic colon cancer.Int J Oncol2009 NovCatela Ivkovic T-
27535135Classical point mutations of RET, BRAF and RAS oncogenes are not shared in papillary and medullary thyroid cancer occurring simultaneously in the same gland.J Endocrinol Invest2017 JanCiampi Rdoi: 10.1007/s40618-016-0526-5
28202657Deciphering the RAS/ERK pathway in vivo.Biochem Soc Trans2017 Feb 8Dorard Cdoi: 10.1042/BST20160135.
27689252Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma.J Clin Endocrinol Metab2016 DecKakarmath S-
28864536Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer.Eur J Endocrinol2017 DecSong YSdoi: 10.1530/EJE-17-0456

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11534286Missense_Mutationrs104894228G13R0.63MMR_HSR1
BLCAchr11533874Missense_Mutationrs121913233Q61L0.67MMR_HSR1
BLCAchr11533875Missense_Mutationrs28933406Q61K0.51MMR_HSR1
BLCAchr11534289Missense_Mutationrs104894229G12S0.11MMR_HSR1
BLCAchr11534285Missense_Mutationrs104894226G13V0.37MMR_HSR1
BLCAchr11534226Missense_MutationnovelD33N0.33MMR_HSR1
BLCAchr11533469Nonsense_MutationnovelS145*0.15
BLCAchr11533874Missense_Mutationrs121913233Q61L0.42MMR_HSR1
BLCAchr11533763Splice_Regionnovel0.23
BLCAchr11533875Missense_Mutationrs28933406Q61K0.39MMR_HSR1
BLCAchr11534286Missense_Mutationrs104894228G13R0.33MMR_HSR1
BLCAchr11532642SilentnovelL188L0.57
BLCAchr11533874Missense_Mutationrs121913233Q61L0.79MMR_HSR1
BLCAchr11534288Missense_Mutationrs104894230G12D0.23MMR_HSR1
BLCAchr11533345Intronnovel0.35
BLCAchr11534285Missense_Mutationrs104894226G13D0.25MMR_HSR1
BLCAchr11533875Missense_Mutationrs28933406Q61K0.53MMR_HSR1
BLCAchr11533552Missense_MutationNAK117N0.34MMR_HSR1
BLCAchr11533312Intronnovel0.79
BLCAchr11533552Missense_MutationNAK117N0.06MMR_HSR1
BLCAchr11533785Missense_MutationNAE91K0.37MMR_HSR1
BLCAchr11534288Missense_Mutationrs104894230G12D0.75MMR_HSR1
BRCAchr11534288Missense_Mutationrs104894230G12D0.42MMR_HSR1
BRCAchr11534289Missense_Mutationrs104894229G12C0.54MMR_HSR1
BRCAchr11533450Splice_Regionnovel0.27
BRCAchr11533787Missense_MutationnovelF90C0.22MMR_HSR1
BRCAchr11532642SilentnovelL188L0.28
BRCAchr11534286Missense_Mutationrs104894228G13R0.41MMR_HSR1
CESCchr11533515Missense_MutationNAA130T0.63
CESCchr115343305'UTRNA0.47
COADchr11533280Intronnovel0.27
COADchr115343465'UTRrs7720636100.41
COADchr11533308Intronrs7642116850.35
COADchr11533573Silentrs200747280P110P0.37
COADchr11533499Missense_MutationnovelR135Q0.24
COADchr11533834Silentrs372223975T74T0.41
COADchr11533878Missense_MutationNAG60S0.27MMR_HSR1
COADchr11532700Missense_Mutationrs142218590R169Q0.36
HNSCchr11533874Missense_Mutationrs121913233Q61L0.26MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.3MMR_HSR1
HNSCchr11534288Missense_Mutationrs104894230G12D0.41MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.36MMR_HSR1
HNSCchr11534288Missense_Mutationrs104894230G12D0.45MMR_HSR1
HNSCchr11533550Missense_MutationnovelC118Y0.32
HNSCchr11533456Frame_Shift_InsnovelQ150Pfs*280.16
HNSCchr11534289Missense_Mutationrs104894229G12S0.21MMR_HSR1
HNSCchr11533830Nonsense_MutationnovelE76*0.34MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12C0.12MMR_HSR1
HNSCchr115343515'UTRnovel0.52
HNSCchr11534286Missense_Mutationrs104894228G13R0.4MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12S0.57MMR_HSR1
HNSCchr11533552Missense_MutationNAK117N0.36MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.12MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.43MMR_HSR1
HNSCchr11533873Missense_MutationNAQ61H0.29MMR_HSR1
HNSCchr11533874Missense_Mutationrs121913233Q61L0.27MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12S0.51MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12S0.13MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12S0.13MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.25MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.33MMR_HSR1
HNSCchr11534286Missense_Mutationrs104894228G13R0.11MMR_HSR1
HNSCchr11533874Missense_Mutationrs121913233Q61L0.25MMR_HSR1
HNSCchr115343405'UTRrs7789541730.55
HNSCchr11534288Missense_Mutationrs104894230G12A0.15MMR_HSR1
HNSCchr11534285Missense_Mutationrs104894226G13V0.14MMR_HSR1
HNSCchr11534286Missense_Mutationrs104894228G13R0.2MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12C0.64MMR_HSR1
HNSCchr11534286Missense_Mutationrs104894228G13C0.71MMR_HSR1
HNSCchr11534289Missense_Mutationrs104894229G12S0.27MMR_HSR1
LUADchr11533899Missense_MutationnovelL53M0.08MMR_HSR1
LUADchr11533462Missense_MutationnovelK147N0.21
LUADchr11533874Missense_Mutationrs121913233Q61L0.4MMR_HSR1
LUSCchr11534286Missense_Mutationrs104894228G13R0.39MMR_HSR1
LUSCchr11534286Missense_Mutationrs104894228G13C0.15MMR_HSR1
LUSCchr11534286Missense_Mutationrs104894228G13C0.67MMR_HSR1
LUSCchr11534288Missense_Mutationrs104894230G12V0.4MMR_HSR1
LUSCchr11534285Missense_Mutationrs104894226G13V0.28MMR_HSR1
LUSCchr11534285Missense_Mutationrs104894226G13V0.24MMR_HSR1
LUSCchr11533875Missense_Mutationrs28933406Q61K0.25MMR_HSR1
LUSCchr11533316Intronnovel0.29
PAADchr11533503Missense_MutationnovelA134T0.16
PCPGchr11533874Missense_Mutationrs121913233Q61L0.26MMR_HSR1
PCPGchr11534286Missense_Mutationrs104894228G13R0.33MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.71MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.5MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.44MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.46MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.33MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.49MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.43MMR_HSR1
PCPGchr11534286Missense_Mutationrs104894228G13R0.59MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.38MMR_HSR1
PCPGchr11533875Missense_Mutationrs28933406Q61K0.33MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.45MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.49MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.33MMR_HSR1
PCPGchr11533875Missense_Mutationrs28933406Q61K0.4MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.84MMR_HSR1
PCPGchr11533874Missense_Mutationrs121913233Q61R0.42MMR_HSR1
PRADchr11533309Intronrs7308804570.08
PRADchr11533874Missense_Mutationrs121913233Q61R0.33MMR_HSR1
PRADchr11533476Missense_MutationNAE143K0.15
PRADchr11533874Missense_Mutationrs121913233Q61R0.28MMR_HSR1
PRADchr11533874Missense_Mutationrs121913233Q61R0.13MMR_HSR1
PRADchr11534269Silentrs148380285A18A0.1
SKCMchr11533312Intronnovel0.75
SKCMchr11533552Missense_MutationNAK117N0.48MMR_HSR1
SKCMchr11534285Missense_Mutationrs104894226G13D0.27MMR_HSR1
SKCMchr11534286Missense_Mutationrs104894228G13S0.27MMR_HSR1
SKCMchr11534285Missense_Mutationrs104894226G13D0.44MMR_HSR1
SKCMchr11533336Intronnovel0.23
SKCMchr11533352Intronrs7480894460.33
SKCMchr11533875Missense_Mutationrs28933406Q61K0.67MMR_HSR1
SKCMchr11533880Frame_Shift_DelnovelA59Rfs*320.38MMR_HSR1
SKCMchr11533875Missense_Mutationrs28933406Q61K0.4MMR_HSR1
STADchr11534290SilentNAA11A0.33
STADchr11532607Intronrs3752197970.4
STADchr11533845Missense_MutationnovelY71H0.44MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.42MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.42MMR_HSR1
THCAchr11533875Missense_Mutationrs28933406Q61K0.38MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.39MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.46MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.28MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.48MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.37MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.4MMR_HSR1
THCAchr11533875Missense_Mutationrs28933406Q61K0.4MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.39MMR_HSR1
THCAchr11533875Missense_Mutationrs28933406Q61K0.3MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.42MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.32MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.4MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.55MMR_HSR1
THCAchr11533874Missense_Mutationrs121913233Q61R0.22MMR_HSR1
THYMchr11533302Intronnovel0.36
THYMchr11534285Missense_Mutationrs104894226G13V0.47MMR_HSR1
THYMchr11533552Missense_MutationNAK117N0.29MMR_HSR1
THYMchr11534289Missense_Mutationrs104894229G12R0.29MMR_HSR1
THYMchr11534285Missense_Mutationrs104894226G13V0.63MMR_HSR1
THYMchr11534284In_Frame_InsnovelG13dup0.26MMR_HSR1
THYMchr11533553Missense_Mutationrs104894227K117R0.27MMR_HSR1
THYMchr11533552Missense_MutationNAK117N0.55MMR_HSR1
THYMchr11533877Missense_MutationnovelG60V0.61MMR_HSR1
THYMchr11534286Missense_Mutationrs104894228G13R0.59MMR_HSR1
THYMchr11533544Missense_MutationnovelL120P0.39
UCECchr11533881Missense_Mutationrs727503093A59T0.55MMR_HSR1
UCECchr11534232Missense_MutationnovelE31K0.49MMR_HSR1
UCECchr11534293Silentrs752765965G10G0.2
UCECchr11534289Missense_Mutationrs104894229G12S0.53MMR_HSR1
UCECchr11532607Intronrs3752197970.16
UCECchr11533934Missense_MutationNAR41Q0.13MMR_HSR1
UCECchr11533523Missense_MutationnovelS127Y0.44
UCECchr11534285Missense_Mutationrs104894226G13D0.51MMR_HSR1
UCECchr11532585Intronrs7718759300.41
UCECchr11533881Missense_Mutationrs727503093A59T0.47MMR_HSR1
UCECchr11533535Missense_MutationNAR123H0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.43872.9151e-06
BRCADEL0.24633.0727e-19
CESCDEL0.29490.02701
ESCAAMP0.11960.018342
ESCADEL0.34780.0016785
GBMDEL0.18370.0048476
HNSCDEL0.24520.00051729
LUADDEL0.19190.00044751
LUSCDEL0.38724.3974e-14
OVDEL0.56824.8003e-42
PAADDEL0.10870.022808
PCPGAMP0.03090.23196
PCPGDEL0.32720.00064285
TGCTDEL0.560.21504
UCECDEL0.17632.4803e-07

Survival Analysis
CancerP-value Q-value
KIRC0.039

Kaplan-Meier Survival Analysis

MESO0.0021

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

SKCM0.00033

Kaplan-Meier Survival Analysis

COAD0.0082

Kaplan-Meier Survival Analysis

PAAD0.0089

Kaplan-Meier Survival Analysis

UCEC0.004

Kaplan-Meier Survival Analysis

GBM0.0039

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

THCA0.037

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000174775 (Gene tree)
Gene ID
3265
Gene Symbol
HRAS
Alias
HRAS1
Full Name
HRas proto-oncogene, GTPase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
5,046 bases
Position
chr11:532,242-537,287
Accession
5173
RBP type
canonical RBP
Summary
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000380722MMR_HSR1PF01926.237.6e-0511
ENSP00000388246MMR_HSR1PF01926.237.6e-0511
ENSP00000309845MMR_HSR1PF01926.239.8e-0511
ENSP00000380723MMR_HSR1PF01926.239.8e-0511
ENSP00000407586MMR_HSR1PF01926.239.8e-0511

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
31061957Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.Hepatol Commun2019 Feb 25Watanabe Kdoi: 10.1002/hep4.1327
3012774Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter.Science1986 Jun 13Ishii S-
7666541An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.J Virol1995 OctBerlioz C-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000478324HRAS-208631--- (aa)--
ENST00000482021HRAS-210167--- (aa)--
ENST00000493230HRAS-2111114-ENSP00000434023170 (aa)-P01112
ENST00000462734HRAS-206627--- (aa)--
ENST00000397594HRAS-2021099-ENSP00000380722170 (aa)-P01112
ENST00000468682HRAS-207749--- (aa)--
ENST00000397596HRAS-2031100-ENSP00000380723189 (aa)-P01112
ENST00000311189HRAS-201894-ENSP00000309845189 (aa)-P01112
ENST00000451590HRAS-2051151-ENSP00000407586189 (aa)-P01112
ENST00000479482HRAS-209485--- (aa)--
ENST00000417302HRAS-2041233-ENSP00000388246170 (aa)-P01112
Gene Model
Click here to download ENSG00000174775's gene model file
Pathways
Pathway IDPathway NameSource
hsa01521EGFR tyrosine kinase inhibitor resistanceKEGG
hsa01522Endocrine resistanceKEGG
hsa04010MAPK signaling pathwayKEGG
hsa04012ErbB signaling pathwayKEGG
hsa04014Ras signaling pathwayKEGG
hsa04015Rap1 signaling pathwayKEGG
hsa04062Chemokine signaling pathwayKEGG
hsa04068FoxO signaling pathwayKEGG
hsa04071Sphingolipid signaling pathwayKEGG
hsa04072Phospholipase D signaling pathwayKEGG
hsa04137Mitophagy - animalKEGG
hsa04140Autophagy - animalKEGG
hsa04144EndocytosisKEGG
hsa04150mTOR signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04210ApoptosisKEGG
hsa04211Longevity regulating pathwayKEGG
hsa04213Longevity regulating pathway - multiple speciesKEGG
hsa04218Cellular senescenceKEGG
hsa04360Axon guidanceKEGG
hsa04370VEGF signaling pathwayKEGG
hsa04371Apelin signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04540Gap junctionKEGG
hsa04550Signaling pathways regulating pluripotency of stem cellsKEGG
hsa04625C-type lectin receptor signaling pathwayKEGG
hsa04630JAK-STAT signaling pathwayKEGG
hsa04650Natural killer cell mediated cytotoxicityKEGG
hsa04660T cell receptor signaling pathwayKEGG
hsa04662B cell receptor signaling pathwayKEGG
hsa04664Fc epsilon RI signaling pathwayKEGG
hsa04714ThermogenesisKEGG
hsa04720Long-term potentiationKEGG
hsa04722Neurotrophin signaling pathwayKEGG
hsa04725Cholinergic synapseKEGG
hsa04726Serotonergic synapseKEGG
hsa04730Long-term depressionKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04910Insulin signaling pathwayKEGG
hsa04912GnRH signaling pathwayKEGG
hsa04915Estrogen signaling pathwayKEGG
hsa04916MelanogenesisKEGG
hsa04917Prolactin signaling pathwayKEGG
hsa04919Thyroid hormone signaling pathwayKEGG
hsa04921Oxytocin signaling pathwayKEGG
hsa04926Relaxin signaling pathwayKEGG
hsa04933AGE-RAGE signaling pathway in diabetic complicationsKEGG
hsa05034AlcoholismKEGG
hsa05160Hepatitis CKEGG
hsa05161Hepatitis BKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
hsa05167Kaposi sarcoma-associated herpesvirus infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05203Viral carcinogenesisKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05206MicroRNAs in cancerKEGG
hsa05210Colorectal cancerKEGG
hsa05211Renal cell carcinomaKEGG
hsa05213Endometrial cancerKEGG
hsa05214GliomaKEGG
hsa05215Prostate cancerKEGG
hsa05216Thyroid cancerKEGG
hsa05218MelanomaKEGG
hsa05219Bladder cancerKEGG
hsa05220Chronic myeloid leukemiaKEGG
hsa05221Acute myeloid leukemiaKEGG
hsa05223Non-small cell lung cancerKEGG
hsa05224Breast cancerKEGG
hsa05225Hepatocellular carcinomaKEGG
hsa05226Gastric cancerKEGG
hsa05230Central carbon metabolism in cancerKEGG
hsa05231Choline metabolism in cancerKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174775's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000174775HRAS10095.767ENSAPOG00000023684hrasb10095.767Acanthochromis_polyacanthus
ENSG00000174775HRAS10096.825ENSAMEG00000010515HRAS7596.825Ailuropoda_melanoleuca
ENSG00000174775HRAS10095.767ENSACIG00000000699hrasb10095.767Amphilophus_citrinellus
ENSG00000174775HRAS10095.767ENSAOCG00000011843hrasb10095.767Amphiprion_ocellaris
ENSG00000174775HRAS10095.767ENSAPEG00000009546hrasb10095.767Amphiprion_percula
ENSG00000174775HRAS10095.767ENSATEG00000020001hrasb10095.767Anabas_testudineus
ENSG00000174775HRAS8998.675ENSAPLG00000012248HRAS10098.780Anas_platyrhynchos
ENSG00000174775HRAS10097.354ENSACAG00000014920HRAS10097.354Anolis_carolinensis
ENSG00000174775HRAS100100.000ENSANAG00000034201HRAS100100.000Aotus_nancymaae
ENSG00000174775HRAS10095.238ENSACLG00000001181hrasb10095.238Astatotilapia_calliptera
ENSG00000174775HRAS10094.180ENSAMXG00000033907hrasb10094.180Astyanax_mexicanus
ENSG00000174775HRAS10095.238ENSAMXG00000035885hrasa10095.238Astyanax_mexicanus
ENSG00000174775HRAS9998.225ENSBTAG00000046644HRAS9998.225Bos_taurus
ENSG00000174775HRAS9676.796WBGene00002335let-609876.796Caenorhabditis_elegans
ENSG00000174775HRAS100100.000ENSCJAG00000012199HRAS100100.000Callithrix_jacchus
ENSG00000174775HRAS9992.899ENSCAFG00000031029HRAS60100.000Canis_familiaris
ENSG00000174775HRAS9999.408ENSCAFG00020007059HRAS9999.408Canis_lupus_dingo
ENSG00000174775HRAS9998.225ENSCHIG00000004808HRAS9998.225Capra_hircus
ENSG00000174775HRAS100100.000ENSTSYG00000003745HRAS100100.000Carlito_syrichta
ENSG00000174775HRAS10099.471ENSCAPG00000000745HRAS10099.471Cavia_aperea
ENSG00000174775HRAS10099.471ENSCPOG00000000101HRAS10099.471Cavia_porcellus
ENSG00000174775HRAS100100.000ENSCCAG00000031453HRAS100100.000Cebus_capucinus
ENSG00000174775HRAS100100.000ENSCATG00000031194HRAS100100.000Cercocebus_atys
ENSG00000174775HRAS10099.471ENSCLAG00000002823HRAS10099.471Chinchilla_lanigera
ENSG00000174775HRAS100100.000ENSCSAG00000011033HRAS100100.000Chlorocebus_sabaeus
ENSG00000174775HRAS10097.354ENSCPBG00000013941-10097.354Chrysemys_picta_bellii
ENSG00000174775HRAS100100.000ENSCANG00000017827HRAS100100.000Colobus_angolensis_palliatus
ENSG00000174775HRAS100100.000ENSCGRG00001018735Hras100100.000Cricetulus_griseus_chok1gshd
ENSG00000174775HRAS100100.000ENSCGRG00000010918Hras100100.000Cricetulus_griseus_crigri
ENSG00000174775HRAS10095.767ENSCSEG00000007927hrasb10095.767Cynoglossus_semilaevis
ENSG00000174775HRAS10095.238ENSCVAG00000008670hrasb10095.238Cyprinodon_variegatus
ENSG00000174775HRAS9980.851ENSDARG00000013161zgc:555588989.222Danio_rerio
ENSG00000174775HRAS10094.180ENSDARG00000005651hrasb10097.222Danio_rerio
ENSG00000174775HRAS10094.709ENSDARG00000098497hrasa10094.709Danio_rerio
ENSG00000174775HRAS9994.681ENSDNOG00000015293HRAS9994.681Dasypus_novemcinctus
ENSG00000174775HRAS100100.000ENSDORG00000028079Hras100100.000Dipodomys_ordii
ENSG00000174775HRAS8986.093FBgn0003205Ras85D9681.215Drosophila_melanogaster
ENSG00000174775HRAS10097.354ENSETEG00000019899HRAS10097.354Echinops_telfairi
ENSG00000174775HRAS10090.476ENSEBUG00000004670hrasb10090.476Eptatretus_burgeri
ENSG00000174775HRAS10097.884ENSECAG00000008473HRAS10097.884Equus_caballus
ENSG00000174775HRAS9196.774ENSEEUG00000014548HRAS9096.774Erinaceus_europaeus
ENSG00000174775HRAS10095.767ENSELUG00000004712HRAS10095.767Esox_lucius
ENSG00000174775HRAS9999.408ENSFCAG00000002990HRAS9999.408Felis_catus
ENSG00000174775HRAS10097.884ENSFALG00000012145HRAS10097.884Ficedula_albicollis
ENSG00000174775HRAS100100.000ENSFDAG00000006760HRAS100100.000Fukomys_damarensis
ENSG00000174775HRAS10094.709ENSFHEG00000010055hrasb10094.709Fundulus_heteroclitus
ENSG00000174775HRAS9496.629ENSGMOG00000010196hrasb9696.629Gadus_morhua
ENSG00000174775HRAS10097.884ENSGALG00000029260H-RAS10097.884Gallus_gallus
ENSG00000174775HRAS10095.767ENSGAFG00000021814hrasb10095.767Gambusia_affinis
ENSG00000174775HRAS10095.767ENSGACG00000011340hrasb10095.767Gasterosteus_aculeatus
ENSG00000174775HRAS10097.354ENSGAGG00000019886-10097.354Gopherus_agassizii
ENSG00000174775HRAS10099.471ENSGGOG00000015438HRAS10099.471Gorilla_gorilla
ENSG00000174775HRAS10095.238ENSHBUG00000011998hrasb10095.238Haplochromis_burtoni
ENSG00000174775HRAS10099.471ENSHGLG00000004508HRAS10099.471Heterocephalus_glaber_female
ENSG00000174775HRAS10099.471ENSHGLG00100012888HRAS10099.471Heterocephalus_glaber_male
ENSG00000174775HRAS10095.238ENSIPUG00000006053hras10095.238Ictalurus_punctatus
ENSG00000174775HRAS10094.180ENSIPUG00000022502hrasb10094.180Ictalurus_punctatus
ENSG00000174775HRAS100100.000ENSSTOG00000021206HRAS100100.000Ictidomys_tridecemlineatus
ENSG00000174775HRAS10099.471ENSJJAG00000022529-10099.471Jaculus_jaculus
ENSG00000174775HRAS10090.476ENSJJAG00000011743-10090.476Jaculus_jaculus
ENSG00000174775HRAS10095.767ENSKMAG00000001922Ha-ras10095.767Kryptolebias_marmoratus
ENSG00000174775HRAS10095.767ENSLBEG00000001905hrasb10095.767Labrus_bergylta
ENSG00000174775HRAS10095.767ENSLACG00000018427HRAS10095.767Latimeria_chalumnae
ENSG00000174775HRAS10095.767ENSLOCG00000000684hrasb10095.767Lepisosteus_oculatus
ENSG00000174775HRAS100100.000ENSMFAG00000039003HRAS100100.000Macaca_fascicularis
ENSG00000174775HRAS100100.000ENSMMUG00000021659HRAS100100.000Macaca_mulatta
ENSG00000174775HRAS100100.000ENSMNEG00000039358HRAS100100.000Macaca_nemestrina
ENSG00000174775HRAS100100.000ENSMLEG00000042070HRAS100100.000Mandrillus_leucophaeus
ENSG00000174775HRAS10095.767ENSMAMG00000004359hrasb10095.767Mastacembelus_armatus
ENSG00000174775HRAS10095.238ENSMZEG00005017583hrasb10095.238Maylandia_zebra
ENSG00000174775HRAS100100.000ENSMAUG00000020006Hras100100.000Mesocricetus_auratus
ENSG00000174775HRAS10099.471ENSMICG00000006472HRAS10099.471Microcebus_murinus
ENSG00000174775HRAS100100.000ENSMOCG00000000744Hras100100.000Microtus_ochrogaster
ENSG00000174775HRAS8898.000ENSMODG00000016580HRAS7198.000Monodelphis_domestica
ENSG00000174775HRAS10095.767ENSMALG00000011273hrasb10095.767Monopterus_albus
ENSG00000174775HRAS10099.471MGP_CAROLIEiJ_G0030681Hras10099.471Mus_caroli
ENSG00000174775HRAS100100.000ENSMUSG00000025499Hras100100.000Mus_musculus
ENSG00000174775HRAS10099.471MGP_PahariEiJ_G0013880Hras10099.471Mus_pahari
ENSG00000174775HRAS10089.418MGP_SPRETEiJ_G0031792-10089.418Mus_spretus
ENSG00000174775HRAS100100.000ENSNGAG00000022044Hras100100.000Nannospalax_galili
ENSG00000174775HRAS100100.000ENSNLEG00000008300HRAS100100.000Nomascus_leucogenys
ENSG00000174775HRAS10099.471ENSODEG00000015703HRAS10099.471Octodon_degus
ENSG00000174775HRAS10095.767ENSONIG00000014560hrasb10095.767Oreochromis_niloticus
ENSG00000174775HRAS9685.976ENSORLG00000024443zgc:555589684.916Oryzias_latipes
ENSG00000174775HRAS10095.238ENSORLG00000018912hrasb10095.238Oryzias_latipes
ENSG00000174775HRAS8991.391ENSORLG00020013690zgc:555589684.916Oryzias_latipes_hni
ENSG00000174775HRAS10095.238ENSORLG00020008129hras10095.238Oryzias_latipes_hni
ENSG00000174775HRAS8991.391ENSORLG00015003353zgc:555589684.916Oryzias_latipes_hsok
ENSG00000174775HRAS10094.180ENSOMEG00000018719hrasb10094.180Oryzias_melastigma
ENSG00000174775HRAS8992.053ENSOMEG00000016685zgc:555589685.475Oryzias_melastigma
ENSG00000174775HRAS10098.413ENSOGAG00000024846HRAS10098.413Otolemur_garnettii
ENSG00000174775HRAS8899.333ENSOARG00000007365HRAS9999.333Ovis_aries
ENSG00000174775HRAS100100.000ENSPPAG00000028620HRAS100100.000Pan_paniscus
ENSG00000174775HRAS88100.000ENSPPRG00000008185HRAS88100.000Panthera_pardus
ENSG00000174775HRAS78100.000ENSPTIG00000006043HRAS100100.000Panthera_tigris_altaica
ENSG00000174775HRAS100100.000ENSPTRG00000034469HRAS100100.000Pan_troglodytes
ENSG00000174775HRAS100100.000ENSPANG00000008022-100100.000Papio_anubis
ENSG00000174775HRAS10099.471ENSPANG00000016633-10099.471Papio_anubis
ENSG00000174775HRAS10094.709ENSPKIG00000000303HRAS10094.709Paramormyrops_kingsleyae
ENSG00000174775HRAS9994.149ENSPKIG00000013507hrasb10093.651Paramormyrops_kingsleyae
ENSG00000174775HRAS10096.825ENSPSIG00000014690HRAS9996.825Pelodiscus_sinensis
ENSG00000174775HRAS7892.481ENSPMGG00000014517zgc:555589492.481Periophthalmus_magnuspinnatus
ENSG00000174775HRAS9696.133ENSPMGG00000005812HRAS8896.133Periophthalmus_magnuspinnatus
ENSG00000174775HRAS100100.000ENSPEMG00000013973-100100.000Peromyscus_maniculatus_bairdii
ENSG00000174775HRAS10089.418ENSPMAG00000004548hrasb9889.418Petromyzon_marinus
ENSG00000174775HRAS10096.825ENSPCIG00000008359HRAS10096.825Phascolarctos_cinereus
ENSG00000174775HRAS10095.767ENSPFOG00000002595hrasb10095.767Poecilia_formosa
ENSG00000174775HRAS10094.709ENSPLAG00000003379hrasb10094.709Poecilia_latipinna
ENSG00000174775HRAS10095.767ENSPMEG00000020891hrasb10095.767Poecilia_mexicana
ENSG00000174775HRAS10095.767ENSPREG00000019341hrasb10095.767Poecilia_reticulata
ENSG00000174775HRAS100100.000ENSPPYG00000002868HRAS100100.000Pongo_abelii
ENSG00000174775HRAS10099.471ENSPCOG00000021838HRAS10099.471Propithecus_coquereli
ENSG00000174775HRAS10095.238ENSPNYG00000015124hrasb10095.238Pundamilia_nyererei
ENSG00000174775HRAS10095.767ENSPNAG00000014085hrasa10095.767Pygocentrus_nattereri
ENSG00000174775HRAS10094.180ENSPNAG00000000584hrasb10094.180Pygocentrus_nattereri
ENSG00000174775HRAS100100.000ENSRNOG00000016611Hras100100.000Rattus_norvegicus
ENSG00000174775HRAS100100.000ENSRBIG00000034835HRAS100100.000Rhinopithecus_bieti
ENSG00000174775HRAS100100.000ENSRROG00000041325HRAS100100.000Rhinopithecus_roxellana
ENSG00000174775HRAS100100.000ENSSBOG00000023272HRAS100100.000Saimiri_boliviensis_boliviensis
ENSG00000174775HRAS9755.080ENSSHAG00000004318-8158.537Sarcophilus_harrisii
ENSG00000174775HRAS10094.180ENSSFOG00015003051hrasb10094.180Scleropages_formosus
ENSG00000174775HRAS10094.180ENSSFOG00015011157-10094.180Scleropages_formosus
ENSG00000174775HRAS10095.767ENSSMAG00000008745hrasb10095.767Scophthalmus_maximus
ENSG00000174775HRAS10095.767ENSSDUG00000019086hrasb10095.767Seriola_dumerili
ENSG00000174775HRAS10095.767ENSSLDG00000012627hrasb10095.767Seriola_lalandi_dorsalis
ENSG00000174775HRAS10097.354ENSSPUG00000005243HRAS10097.354Sphenodon_punctatus
ENSG00000174775HRAS10095.238ENSSPAG00000007357hrasb10095.238Stegastes_partitus
ENSG00000174775HRAS10097.354ENSSSCG00000031513HRAS10097.354Sus_scrofa
ENSG00000174775HRAS10097.884ENSTGUG00000009877HRAS10097.884Taeniopygia_guttata
ENSG00000174775HRAS10094.709ENSTRUG00000024825hrasb10094.709Takifugu_rubripes
ENSG00000174775HRAS10094.709ENSTNIG00000011385hrasb10094.709Tetraodon_nigroviridis
ENSG00000174775HRAS10096.296ENSTTRG00000011120HRAS10096.296Tursiops_truncatus
ENSG00000174775HRAS9999.408ENSUAMG00000027527-9999.408Ursus_americanus
ENSG00000174775HRAS9998.817ENSUMAG00000005506-9998.817Ursus_maritimus
ENSG00000174775HRAS10097.884ENSVVUG00000017151HRAS10097.884Vulpes_vulpes
ENSG00000174775HRAS10096.296ENSXETG00000006040hras10096.296Xenopus_tropicalis
ENSG00000174775HRAS9497.740ENSXCOG00000020608hrasb9494.656Xiphophorus_couchianus
ENSG00000174775HRAS10095.767ENSXMAG00000015132hrasb10095.767Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000139Golgi membrane-IEAComponent
GO:0000165MAPK cascade-TASProcess
GO:0001934positive regulation of protein phosphorylation22065586.IDAProcess
GO:0002223stimulatory C-type lectin receptor signaling pathway-TASProcess
GO:0003924GTPase activity9178006.IDAFunction
GO:0003924GTPase activity9230043.IMPFunction
GO:0005515protein binding2122974.8332187.8670882.9144171.9447984.9488663.9690470.10369681.10608844.11022048.11335720.11598133.11857081.11980706.12620389.12628188.14500341.14724641.15507210.15886098.16316996.16698549.17084389.17540175.18073111.18273062.18454158.18596699.19063885.19141281.19222999.19696784.20080631.20133692.20133694.20178605.20936779.22020336.22169110.24441586.24929361.25241761.25684575.26165597.IPIFunction
GO:0005525GTP binding14500341.17260967.IDAFunction
GO:0005525GTP binding9230043.IMPFunction
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm10842192.TASComponent
GO:0005794Golgi apparatus14500341.21968647.IDAComponent
GO:0005886plasma membrane14500341.17724343.21968647.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0006897endocytosis-IEAProcess
GO:0006935chemotaxis10848592.TASProcess
GO:0007050cell cycle arrest9054499.IDAProcess
GO:0007050cell cycle arrest9765203.IMPProcess
GO:0007093mitotic cell cycle checkpoint9054499.IDAProcess
GO:0007165signal transduction8607982.NASProcess
GO:0007166cell surface receptor signaling pathway9020890.TASProcess
GO:0007265Ras protein signal transduction23027131.IDAProcess
GO:0007265Ras protein signal transduction-TASProcess
GO:0008022protein C-terminus binding9219684.IPIFunction
GO:0008283cell proliferation-IEAProcess
GO:0008284positive regulation of cell proliferation9765203.IDAProcess
GO:0008285negative regulation of cell proliferation9054499.IDAProcess
GO:0009887animal organ morphogenesis10848592.TASProcess
GO:0010629negative regulation of gene expression23027131.IDAProcess
GO:0010863positive regulation of phospholipase C activity11022048.IDAProcess
GO:0019003GDP binding8142349.9230043.IMPFunction
GO:0030335positive regulation of cell migration23027131.IDAProcess
GO:0032729positive regulation of interferon-gamma production-IEAProcess
GO:0034260negative regulation of GTPase activity23027131.IDAProcess
GO:0035900response to isolation stress-IEAProcess
GO:0042088T-helper 1 type immune response-IEAProcess
GO:0042832defense response to protozoan-IEAProcess
GO:0043406positive regulation of MAP kinase activity23027131.IDAProcess
GO:0043410positive regulation of MAPK cascade9765203.IDAProcess
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0043547positive regulation of GTPase activity23027131.IDAProcess
GO:0045740positive regulation of DNA replication-IEAProcess
GO:0045944positive regulation of transcription by RNA polymerase II22065586.23027131.IDAProcess
GO:0046330positive regulation of JNK cascade22065586.IDAProcess
GO:0046579positive regulation of Ras protein signal transduction-IEAProcess
GO:0048013ephrin receptor signaling pathway-TASProcess
GO:0048169regulation of long-term neuronal synaptic plasticity-IEAProcess
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0050679positive regulation of epithelial cell proliferation20154697.IMPProcess
GO:0050852T cell receptor signaling pathway-IEAProcess
GO:0051291protein heterooligomerization-IEAProcess
GO:0070374positive regulation of ERK1 and ERK2 cascade22065586.IDAProcess
GO:0071480cellular response to gamma radiation16213212.IDAProcess
GO:0090303positive regulation of wound healing23027131.IDAProcess
GO:0090314positive regulation of protein targeting to membrane11022048.IMPProcess
GO:0090398cellular senescence9054499.IDAProcess
GO:0097193intrinsic apoptotic signaling pathway-IEAProcess
GO:0098696regulation of neurotransmitter receptor localization to postsynaptic specialization membrane12202034.EXPProcess
GO:0098696regulation of neurotransmitter receptor localization to postsynaptic specialization membrane12202034.IDAProcess
GO:0098978glutamatergic synapse12202034.EXPComponent
GO:0098978glutamatergic synapse12202034.IDAComponent
GO:1900029positive regulation of ruffle assembly23027131.IDAProcess
GO:2000251positive regulation of actin cytoskeleton reorganization23027131.IDAProcess
GO:2000630positive regulation of miRNA metabolic process23027131.IDAProcess
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