EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25314918	Relevance of LIG4 gene polymorphisms with cancer susceptibility: evidence from a meta-analysis.	Sci Rep	2014 Oct 15	Xie S	doi: 10.1038/srep06630.
21974800	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.	Cancer Epidemiol	2012 Apr	Reeves SG	doi: 10.1016/j.canep.2011.09.003
25811031	Associations of LIG4 and HSPB1 genetic polymorphisms with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.	Biomed Res Int	2015	Xu F	doi: 10.1155/2015/860373
25605214	DNA ligase4 as a prognostic marker in nasopharyngeal cancer patients treated with radiotherapy.	Asian Pac J Cancer Prev	2014	Kim DH	-
24722796	The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.	Med Oncol	2014 May	Jiang YH	doi: 10.1007/s12032-014-0959-7
26134445	Expression of DNA ligase IV is linked to poor prognosis and characterizes a subset of prostate cancers harboring TMPRSS2:ERG fusion and PTEN deletion.	Oncol Rep	2015 Sep	Grupp K	doi: 10.3892/or.2015.4080
24282031	Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer.	Hum Mol Genet	2014 Apr 15	Kuhmann C	doi: 10.1093/hmg/ddt599
20811692	The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk.	Oncol Rep	2010 Oct	Gomes BC	-
27009971	LIG4 mediates Wnt signalling-induced radioresistance.	Nat Commun	2016 Mar 24	Jun S	doi: 10.1038/ncomms10994.
18508926	DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.	Mol Biol Cell	2008 Aug	Friesen C	doi: 10.1091/mbc.E08-03-0306
22994770	Lack of association between LIG4 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.	Asian Pac J Cancer Prev	2012	Zhou LP	-
28976792	Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.	J Clin Oncol	2017 Nov 10	Wang X	doi: 10.1200/JCO.2017.74.7444

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr13	108209950	Missense_Mutation	novel	P440R	0.7	RNA_ligase
BLCA	chr13	108210901	Missense_Mutation	novel	G123A	0.33
BLCA	chr13	108208825	Missense_Mutation	rs574090677	R815H	0.28
BLCA	chr13	108208553	Missense_Mutation	NA	E906K	0.32
BLCA	chr13	108208841	Missense_Mutation	NA	L810V	0.32
BLCA	chr13	108209873	Missense_Mutation	novel	I466F	0.15
BLCA	chr13	108208632	Missense_Mutation	novel	R879S	0.21
BLCA	chr13	108208733	Missense_Mutation	rs778998772	R846W	0.57
BLCA	chr13	108209232	Silent	novel	E679E	0.35
BLCA	chr13	108209495	Missense_Mutation	NA	E592K	0.32
BRCA	chr13	108210437	Missense_Mutation	rs574912936	R278C	0.09	RNA_ligase
BRCA	chr13	108210569	Missense_Mutation	novel	G234R	0.07
BRCA	chr13	108210110	Missense_Mutation	NA	E387K	0.17	RNA_ligase
BRCA	chr13	108209605	Missense_Mutation	NA	V555G	0.21
BRCA	chr13	108211188	Silent	novel	Q27Q	0.16
CESC	chr13	108210763	Frame_Shift_Del	novel	*K169Rfs7**	0.22
CESC	chr13	108211041	Missense_Mutation	NA	E76D	0.17
CESC	chr13	108211035	Frame_Shift_Ins	novel	*R79Efs7**	0.15
CESC	chr13	108209883	Silent	NA	L462L	0.62
CESC	chr13	108209493	Silent	novel	E592E	0.29
CESC	chr13	108209316	Silent	rs780588115	N651N	0.39
CESC	chr13	108208863	Frame_Shift_Del	novel	*R802Lfs25**	0.15
CESC	chr13	108208864	In_Frame_Ins	novel	R802delinsLPQW	0.15
CESC	chr13	108208817	Missense_Mutation	rs534543979	V818I	0.2
CESC	chr13	108208667	Missense_Mutation	NA	D868N	0.38
CESC	chr13	108208804	Missense_Mutation	rs141441003	S822L	0.13
CESC	chr13	108209389	Frame_Shift_Del	novel	*K627Sfs8**	0.17
CESC	chr13	108210080	Missense_Mutation	NA	P397S	0.71	RNA_ligase
CESC	chr13	108208827	Silent	NA	R814R	0.29
COAD	chr13	108208858	Missense_Mutation	NA	S804F	0.37
COAD	chr13	108209227	Missense_Mutation	NA	R681I	0.47
COAD	chr13	108208941	Missense_Mutation	NA	E776D	0.24
COAD	chr13	108208963	Missense_Mutation	rs761592929	T769I	0.27
COAD	chr13	108209178	Silent	rs184527984	T697T	0.22
COAD	chr13	108209439	Silent	rs768563098	L610L	0.31
COAD	chr13	108208519	3'UTR	novel		0.07
COAD	chr13	108209883	Frame_Shift_Ins	novel	*L462Ffs12**	0.14
COAD	chr13	108210763	Frame_Shift_Del	novel	*K169Rfs7**	0.11
COAD	chr13	108208733	Missense_Mutation	rs778998772	R846W	0.54
COAD	chr13	108209478	Silent	rs144253952	D597D	0.21
COAD	chr13	108208821	Missense_Mutation	NA	H816Q	0.22
COAD	chr13	108208500	3'UTR	novel		0.25
COAD	chr13	108210319	Missense_Mutation	novel	N317S	0.09	RNA_ligase
COAD	chr13	108209015	Nonsense_Mutation	NA	E752*	0.31
COAD	chr13	108209722	Missense_Mutation	NA	Y516C	0.17
ESCA	chr13	108208500	3'UTR	novel		0.28
ESCA	chr13	108210962	Nonsense_Mutation	novel	G103*	0.27
ESCA	chr13	108209007	Missense_Mutation	novel	F754L	0.5
GBM	chr13	108209530	Missense_Mutation	rs146616552	R580Q	0.32
GBM	chr13	108210391	Missense_Mutation	rs775560383	R293Q	0.53	RNA_ligase
GBM	chr13	108208972	Missense_Mutation	novel	F766C	0.08
HNSC	chr13	108211043	Missense_Mutation	novel	E76K	0.1
HNSC	chr13	108209316	Silent	rs780588115	N651N	0.13
HNSC	chr13	108209624	Missense_Mutation	NA	I549F	0.71
HNSC	chr13	108209384	Nonsense_Mutation	NA	K629*	0.31
HNSC	chr13	108208598	Missense_Mutation	novel	E891Q	0.34
HNSC	chr13	108210311	Missense_Mutation	novel	K320Q	0.54	RNA_ligase
HNSC	chr13	108209405	Missense_Mutation	novel	E622K	0.26
HNSC	chr13	108211234	Missense_Mutation	novel	S12C	0.22
HNSC	chr13	108208782	Silent	novel	L829L	0.2
KIRC	chr13	108208715	Missense_Mutation	NA	V852I	0.34
LAML	chr13	108210087	Silent	novel	T394T	0.11
LGG	chr13	108211225	Missense_Mutation	NA	P15R	0.19
LGG	chr13	108208899	Silent	rs748625382	E790E	0.33
LGG	chr13	108209988	Missense_Mutation	novel	E427D	0.1	RNA_ligase
LIHC	chr13	108211181	Missense_Mutation	novel	K30E	0.16
LIHC	chr13	108211274	5'UTR	rs576972519		0.09
LUAD	chr13	108209745	Silent	novel	S508S	0.23
LUAD	chr13	108209940	Silent	novel	R443R	0.2
LUAD	chr13	108209936	Nonsense_Mutation	NA	E445*	0.35	RNA_ligase
LUAD	chr13	108208598	Missense_Mutation	novel	E891K	0.14
LUAD	chr13	108210995	Missense_Mutation	novel	L92V	0.18
LUAD	chr13	108210823	Missense_Mutation	NA	N149I	0.71
LUAD	chr13	108210825	Silent	NA	V148V	0.69
LUAD	chr13	108209904	Silent	novel	V455V	0.04
LUAD	chr13	108209432	Missense_Mutation	novel	K613E	0.31
LUAD	chr13	108209237	Silent	NA	L678L	0.19
LUAD	chr13	108208591	Missense_Mutation	NA	W893L	0.3
LUAD	chr13	108209006	Missense_Mutation	novel	A755S	0.13
LUAD	chr13	108209175	Silent	novel	Y698Y	0.23
LUAD	chr13	108209208	Silent	NA	G687G	0.37
LUAD	chr13	108210062	Missense_Mutation	novel	V403L	0.27	RNA_ligase
LUAD	chr13	108210577	Missense_Mutation	NA	P231L	0.24
LUAD	chr13	108211233	Silent	novel	S12S	0.44
LUSC	chr13	108208625	Missense_Mutation	novel	F882I	0.19
LUSC	chr13	108210115	Missense_Mutation	novel	R385T	0.76	RNA_ligase
LUSC	chr13	108209836	Missense_Mutation	novel	G478V	0.16
LUSC	chr13	108209582	Missense_Mutation	NA	E563K	0.38
LUSC	chr13	108208768	Missense_Mutation	NA	E834V	0.36
LUSC	chr13	108209094	Missense_Mutation	novel	W725C	0.46
LUSC	chr13	108209577	Silent	rs750170673	I564I	0.33
LUSC	chr13	108211044	Silent	novel	L75L	0.33
LUSC	chr13	108210058	Missense_Mutation	novel	Q404L	0.05	RNA_ligase
LUSC	chr13	108210059	Nonsense_Mutation	novel	Q404*	0.06	RNA_ligase
LUSC	chr13	108209955	Nonsense_Mutation	novel	Y438*	0.04	RNA_ligase
LUSC	chr13	108209717	Silent	novel	L518L	0.65
LUSC	chr13	108209210	Missense_Mutation	NA	G687C	0.38
LUSC	chr13	108210812	Missense_Mutation	NA	D153Y	0.13
LUSC	chr13	108208884	Silent	NA	L795L	0.5
LUSC	chr13	108209888	Missense_Mutation	rs139785910	E461K	0.1
LUSC	chr13	108210922	Missense_Mutation	novel	T116S	0.2
LUSC	chr13	108211160	Nonsense_Mutation	NA	R37*	0.38
LUSC	chr13	108210450	Silent	rs369808832	K273K	0.24
LUSC	chr13	108210343	Missense_Mutation	NA	G309V	0.07	RNA_ligase
LUSC	chr13	108210202	Missense_Mutation	NA	E356V	0.17	RNA_ligase
LUSC	chr13	108209958	Silent	NA	I437I	0.24
LUSC	chr13	108210133	Missense_Mutation	novel	H379R	0.51	RNA_ligase
LUSC	chr13	108208667	Missense_Mutation	NA	D868Y	0.15
LUSC	chr13	108209028	Nonsense_Mutation	novel	C747*	0.41
LUSC	chr13	108209210	Missense_Mutation	NA	G687C	0.41
LUSC	chr13	108210057	Silent	NA	Q404Q	0.11
LUSC	chr13	108210232	Frame_Shift_Del	novel	*G346Efs10**	0.5	RNA_ligase
LUSC	chr13	108209842	Missense_Mutation	novel	R476L	0.17
LUSC	chr13	108209163	Silent	novel	A702A	0.19
LUSC	chr13	108209188	Missense_Mutation	novel	G694V	0.29
LUSC	chr13	108209291	Missense_Mutation	novel	E660K	0.15
OV	chr13	108209035	Missense_Mutation	novel	H745P	0.07
OV	chr13	108209232	Missense_Mutation	novel	E679D	0.19
OV	chr13	108209794	Missense_Mutation	NA	P492L	0.23
OV	chr13	108210690	Frame_Shift_Del	novel	I191*	0.05
OV	chr13	108209324	Missense_Mutation	NA	L649F	0.19
OV	chr13	108209480	Missense_Mutation	NA	D597Y	0.12
OV	chr13	108208964	Missense_Mutation	novel	T769S	0.2
PAAD	chr13	108208753	Missense_Mutation	novel	A839D	0.16
PAAD	chr13	108209694	Nonsense_Mutation	novel	Y525*	0.17
PAAD	chr13	108210880	Missense_Mutation	NA	Y130C	0.2
PRAD	chr13	108209103	Silent	NA	K722K	0.08
PRAD	chr13	108211175	Missense_Mutation	rs770549827	R32C	0.27
PRAD	chr13	108210134	Missense_Mutation	NA	H379Y	0.13	RNA_ligase
PRAD	chr13	108209680	Missense_Mutation	rs766018641	H530R	0.24
PRAD	chr13	108209438	Missense_Mutation	rs187323251	A611T	0.4
PRAD	chr13	108210611	Missense_Mutation	novel	D220N	0.32
READ	chr13	108211093	Missense_Mutation	novel	D59G	0.27
READ	chr13	108209784	Silent	NA	E495E	0.93
READ	chr13	108210156	Missense_Mutation	novel	M371I	0.1	RNA_ligase
READ	chr13	108211070	Missense_Mutation	novel	A67T	0.5
READ	chr13	108209179	Missense_Mutation	NA	T697M	0.15
READ	chr13	108209268	Missense_Mutation	NA	M667I	0.09
SARC	chr13	108210951	Silent	novel	A106A	0.31
SARC	chr13	108209777	Missense_Mutation	novel	S498P	0.13
SARC	chr13	108209249	Missense_Mutation	novel	P674A	0.09
SKCM	chr13	108210544	Frame_Shift_Del	novel	*L242Ifs5**	0.23
SKCM	chr13	108210578	Missense_Mutation	rs3093765	P231S	0.5
SKCM	chr13	108208784	Silent	rs765951039	L829L	0.18
SKCM	chr13	108211026	Silent	rs772726458	A81A	0.22
SKCM	chr13	108208522	3'UTR	novel		0.63
SKCM	chr13	108211081	Missense_Mutation	novel	S63F	0.35
SKCM	chr13	108209768	Missense_Mutation	rs766039537	H501Y	0.49
SKCM	chr13	108209024	Missense_Mutation	rs138080550	S749P	0.16
SKCM	chr13	108210080	Missense_Mutation	NA	P397S	0.44	RNA_ligase
SKCM	chr13	108211281	5'UTR	novel		0.19
SKCM	chr13	108208971	Silent	novel	F766F	0.46
SKCM	chr13	108210079	Missense_Mutation	novel	P397L	0.48	RNA_ligase
SKCM	chr13	108208708	Missense_Mutation	NA	S854F	0.4
SKCM	chr13	108209240	Missense_Mutation	NA	D677N	0.36
SKCM	chr13	108209450	Missense_Mutation	novel	S607T	0.37
SKCM	chr13	108211226	Missense_Mutation	rs201433057	P15S	0.74
STAD	chr13	108209320	Missense_Mutation	NA	T650N	0.33
STAD	chr13	108209340	Silent	novel	H643H	0.61
STAD	chr13	108209531	Missense_Mutation	rs104894418	R580G	0.18
STAD	chr13	108210303	Silent	NA	D322D	0.37
STAD	chr13	108210081	Missense_Mutation	novel	I396M	0.21	RNA_ligase
STAD	chr13	108210762	Frame_Shift_Ins	novel	*S170Efs13**	0.33
STAD	chr13	108209438	Missense_Mutation	rs187323251	A611T	0.21
STAD	chr13	108209794	Frame_Shift_Del	rs767195999	*P492Lfs21**	0.13
STAD	chr13	108209112	Missense_Mutation	novel	D719E	0.15
STAD	chr13	108210960	Silent	NA	G103G	0.23
STAD	chr13	108208657	Missense_Mutation	rs183928755	R871H	0.11
STAD	chr13	108209405	Missense_Mutation	novel	E622K	0.05
STAD	chr13	108208825	Missense_Mutation	rs574090677	R815H	0.08
STAD	chr13	108209576	Missense_Mutation	rs140584260	V565I	0.46
STAD	chr13	108209849	Nonsense_Mutation	NA	G474*	0.26
THCA	chr13	108209357	Missense_Mutation	NA	I638V	0.32
UCEC	chr13	108209843	Missense_Mutation	rs747450004	R476W	0.42
UCEC	chr13	108209605	Missense_Mutation	NA	V555G	0.31
UCEC	chr13	108211135	Missense_Mutation	NA	S45Y	0.3
UCEC	chr13	108208885	Missense_Mutation	NA	L795R	0.3
UCEC	chr13	108210757	Missense_Mutation	NA	L171R	0.24
UCEC	chr13	108210172	Missense_Mutation	novel	V366A	0.33	RNA_ligase
UCEC	chr13	108209613	Silent	rs543175901	C552C	0.31
UCEC	chr13	108210164	Missense_Mutation	novel	V369I	0.41	RNA_ligase
UCEC	chr13	108209249	Missense_Mutation	novel	P674S	0.11
UCEC	chr13	108208630	Missense_Mutation	novel	R880I	0.39
UCEC	chr13	108211206	Silent	novel	S21S	0.48
UCEC	chr13	108209547	Nonsense_Mutation	novel	C574*	0.18
UCEC	chr13	108209853	Silent	NA	G472G	0.24
UCEC	chr13	108209178	Silent	rs184527984	T697T	0.35
UCEC	chr13	108210987	Missense_Mutation	NA	I94M	0.27
UCEC	chr13	108210125	Missense_Mutation	novel	L382M	0.18	RNA_ligase
UCEC	chr13	108208524	3'UTR	novel		0.4
UCEC	chr13	108209067	Missense_Mutation	NA	S734R	0.26
UCEC	chr13	108208829	Nonsense_Mutation	rs104894419	R814*	0.73
UCEC	chr13	108208920	Missense_Mutation	novel	N783K	0.35
UCEC	chr13	108208922	Missense_Mutation	novel	N783H	0.45
UCEC	chr13	108210442	Missense_Mutation	novel	G276V	0.39	RNA_ligase
UCEC	chr13	108209952	Silent	novel	K439K	0.38
UCEC	chr13	108208829	Nonsense_Mutation	rs104894419	R814*	0.44
UCEC	chr13	108208610	Missense_Mutation	rs780983005	K887E	0.41
UCEC	chr13	108210822	Silent	rs766338799	N149N	0.5
UCEC	chr13	108209760	Silent	novel	L503L	0.38
UCEC	chr13	108210529	Missense_Mutation	novel	K247R	0.37
UCEC	chr13	108210392	Nonsense_Mutation	novel	R293*	0.4	RNA_ligase
UCEC	chr13	108210090	Frame_Shift_Del	novel	*F393Lfs8**	0.5	RNA_ligase
UCEC	chr13	108208624	Missense_Mutation	novel	F882C	0.38
UCEC	chr13	108208803	Silent	rs752539259	S822S	0.32
UCEC	chr13	108208865	Missense_Mutation	rs545309994	R802W	0.13
UCEC	chr13	108211196	Nonsense_Mutation	rs753883369	R25*	0.4
UCEC	chr13	108209827	Missense_Mutation	novel	S481F	0.29
UCEC	chr13	108210287	Missense_Mutation	NA	L328I	0.35	RNA_ligase
UCEC	chr13	108210755	Missense_Mutation	novel	L172F	0.34
UCEC	chr13	108208687	Missense_Mutation	novel	S861Y	0.32
UCEC	chr13	108208829	Nonsense_Mutation	rs104894419	R814*	0.46
UCEC	chr13	108210790	Missense_Mutation	novel	S160F	0.34
UCEC	chr13	108209905	Missense_Mutation	novel	V455G	0.03
UCEC	chr13	108210396	Missense_Mutation	NA	F291L	0.19	RNA_ligase
UCEC	chr13	108208624	Missense_Mutation	novel	F882C	0.12
UCEC	chr13	108209206	Missense_Mutation	novel	Y688C	0.08
UCEC	chr13	108210090	Frame_Shift_Del	novel	*F393Lfs8**	0.29	RNA_ligase
UCEC	chr13	108211009	Missense_Mutation	NA	T87N	0.36
UCEC	chr13	108210297	Silent	NA	Q324Q	0.17
UCEC	chr13	108210134	Missense_Mutation	NA	H379Y	0.29	RNA_ligase
UCEC	chr13	108208536	Missense_Mutation	NA	I911M	0.53
UCEC	chr13	108210747	Silent	NA	L174L	0.37
UCEC	chr13	108209464	Missense_Mutation	NA	L602R	0.28
UCEC	chr13	108209653	Nonsense_Mutation	NA	L539*	0.35
UCEC	chr13	108210943	Missense_Mutation	novel	L109R	0.24
UCEC	chr13	108208412	3'UTR	novel		0.34
UCEC	chr13	108209756	Missense_Mutation	rs375284799	R505C	0.22
UCEC	chr13	108208942	Missense_Mutation	novel	E776G	0.18
UCEC	chr13	108209179	Missense_Mutation	NA	T697M	0.53
UCEC	chr13	108208737	Missense_Mutation	novel	E844D	0.33
UCS	chr13	108210312	Missense_Mutation	novel	F319L	0.34	RNA_ligase
UCS	chr13	108209078	Missense_Mutation	novel	K731E	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	AMP	0.1231	0.012126
CESC	AMP	0.2068	0.00028304
GBM	AMP	0.0329	0.012908
LGG	AMP	0.0351	0.0023276
LIHC	AMP	0.1459	2.2054e-10
LUAD	AMP	0.1085	0.027609
SKCM	DEL	0.1826	0.098096

Survival Analysis

Cancer	P-value	Q-value
THYM	0.01	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PRAD	0.0068	Kaplan-Meier Survival Analysis
LUSC	0.027	Kaplan-Meier Survival Analysis
KIRP	0.029	Kaplan-Meier Survival Analysis
PAAD	0.013	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
BLCA	0.04	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000174405 (Gene tree)
Gene ID: 3981
Gene Symbol: LIG4
Alias: -
Full Name: DNA ligase 4
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 10,930 bases
Position: chr13:108,207,439-108,218,368
Accession: 6601
Summary: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000480814	RNA_ligase	PF09414.10	1.5e-08	1	1
ENSP00000349393	RNA_ligase	PF09414.10	1.6e-08	1	1
ENSP00000385955	RNA_ligase	PF09414.10	1.6e-08	1	1
ENSP00000402030	RNA_ligase	PF09414.10	1.6e-08	1	1
ENSP00000484288	RNA_ligase	PF09414.10	1.6e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20926767	Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.	Am J Physiol Regul Integr Comp Physiol	2010 Dec	Trollmann R	doi: 10.1152/ajpregu.00697.2009
30994454	Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.	Elife	2019 Apr 17	Gao R	doi: 10.7554/eLife.42988.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000614526	LIG4-205	3884	XM_017020573	ENSP00000480814	844 (aa)	XP_016876062	A0A0C4DGV9
ENST00000442234	LIG4-203	3982	XM_005254056	ENSP00000402030	911 (aa)	XP_005254113	P49917
ENST00000356922	LIG4-201	4096	XM_017020564	ENSP00000349393	911 (aa)	XP_016876053	P49917
ENST00000611712	LIG4-204	4180	XM_005254058	ENSP00000484288	911 (aa)	XP_005254115	P49917
ENST00000405925	LIG4-202	4065	-	ENSP00000385955	911 (aa)	-	P49917

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03450	Non-homologous end-joining	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000174405	Carotid Artery Diseases	7.51545154846385E-6	17903303
ENSG00000174405	Urinalysis	2.03163196377317E-6	17903293

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174405's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174405	LIG4	100	66.588	ENSAPOG00000000866	lig4	99	66.154	Acanthochromis_polyacanthus
ENSG00000174405	LIG4	100	89.810	ENSAMEG00000019685	LIG4	99	89.352	Ailuropoda_melanoleuca
ENSG00000174405	LIG4	99	67.260	ENSACIG00000018309	lig4	99	66.997	Amphilophus_citrinellus
ENSG00000174405	LIG4	100	66.706	ENSAOCG00000011768	lig4	99	66.154	Amphiprion_ocellaris
ENSG00000174405	LIG4	100	66.825	ENSAPEG00000017815	lig4	99	66.264	Amphiprion_percula
ENSG00000174405	LIG4	100	66.825	ENSATEG00000005583	lig4	99	66.189	Anabas_testudineus
ENSG00000174405	LIG4	100	76.303	ENSAPLG00000001673	LIG4	99	76.136	Anas_platyrhynchos
ENSG00000174405	LIG4	100	76.422	ENSACAG00000014566	LIG4	99	76.744	Anolis_carolinensis
ENSG00000174405	LIG4	100	96.158	ENSANAG00000012446	LIG4	100	96.158	Aotus_nancymaae
ENSG00000174405	LIG4	99	66.548	ENSACLG00000027051	lig4	99	66.007	Astatotilapia_calliptera
ENSG00000174405	LIG4	100	65.640	ENSAMXG00000008192	lig4	94	64.770	Astyanax_mexicanus
ENSG00000174405	LIG4	100	89.243	ENSBTAG00000015868	LIG4	100	89.243	Bos_taurus
ENSG00000174405	LIG4	100	95.280	ENSCJAG00000014689	LIG4	100	95.280	Callithrix_jacchus
ENSG00000174405	LIG4	100	90.999	ENSCAFG00000006031	LIG4	100	90.999	Canis_familiaris
ENSG00000174405	LIG4	100	90.999	ENSCAFG00020021230	LIG4	100	90.999	Canis_lupus_dingo
ENSG00000174405	LIG4	100	88.913	ENSCHIG00000001019	LIG4	100	88.913	Capra_hircus
ENSG00000174405	LIG4	100	87.915	ENSCAPG00000006284	LIG4	99	88.372	Cavia_aperea
ENSG00000174405	LIG4	100	88.364	ENSCPOG00000014266	LIG4	100	88.364	Cavia_porcellus
ENSG00000174405	LIG4	100	95.499	ENSCCAG00000019971	LIG4	100	95.499	Cebus_capucinus
ENSG00000174405	LIG4	100	97.393	ENSCATG00000021075	LIG4	100	97.146	Cercocebus_atys
ENSG00000174405	LIG4	100	89.682	ENSCLAG00000003376	LIG4	100	89.682	Chinchilla_lanigera
ENSG00000174405	LIG4	100	97.393	ENSCSAG00000000211	LIG4	100	97.256	Chlorocebus_sabaeus
ENSG00000174405	LIG4	100	79.787	ENSCPBG00000023291	LIG4	100	79.303	Chrysemys_picta_bellii
ENSG00000174405	LIG4	67	46.573	ENSCING00000009536	-	95	45.310	Ciona_intestinalis
ENSG00000174405	LIG4	83	46.088	ENSCSAVG00000010336	-	98	45.204	Ciona_savignyi
ENSG00000174405	LIG4	100	97.393	ENSCANG00000005805	LIG4	100	97.256	Colobus_angolensis_palliatus
ENSG00000174405	LIG4	100	86.952	ENSCGRG00001012072	Lig4	100	86.952	Cricetulus_griseus_chok1gshd
ENSG00000174405	LIG4	100	86.952	ENSCGRG00000013417	Lig4	100	86.952	Cricetulus_griseus_crigri
ENSG00000174405	LIG4	97	67.718	ENSCSEG00000013905	lig4	95	66.931	Cynoglossus_semilaevis
ENSG00000174405	LIG4	100	67.180	ENSCVAG00000007896	lig4	99	66.556	Cyprinodon_variegatus
ENSG00000174405	LIG4	100	65.089	ENSDARG00000060620	lig4	98	64.452	Danio_rerio
ENSG00000174405	LIG4	100	90.132	ENSDNOG00000000513	LIG4	100	90.132	Dasypus_novemcinctus
ENSG00000174405	LIG4	100	88.913	ENSDORG00000027303	Lig4	100	88.913	Dipodomys_ordii
ENSG00000174405	LIG4	90	31.389	FBgn0030506	Lig4	91	31.389	Drosophila_melanogaster
ENSG00000174405	LIG4	100	84.024	ENSETEG00000015563	LIG4	100	84.812	Echinops_telfairi
ENSG00000174405	LIG4	99	43.878	ENSEBUG00000014243	lig4	99	43.816	Eptatretus_burgeri
ENSG00000174405	LIG4	100	91.328	ENSEASG00005022073	LIG4	100	91.328	Equus_asinus_asinus
ENSG00000174405	LIG4	100	90.889	ENSECAG00000003257	LIG4	100	90.889	Equus_caballus
ENSG00000174405	LIG4	100	67.494	ENSELUG00000006787	lig4	99	67.034	Esox_lucius
ENSG00000174405	LIG4	100	90.121	ENSFCAG00000031985	LIG4	100	90.121	Felis_catus
ENSG00000174405	LIG4	89	76.753	ENSFALG00000004214	LIG4	98	76.753	Ficedula_albicollis
ENSG00000174405	LIG4	100	89.682	ENSFDAG00000008973	LIG4	100	89.682	Fukomys_damarensis
ENSG00000174405	LIG4	100	65.877	ENSFHEG00000007398	lig4	89	65.449	Fundulus_heteroclitus
ENSG00000174405	LIG4	85	64.861	ENSGMOG00000012843	lig4	99	64.698	Gadus_morhua
ENSG00000174405	LIG4	100	76.540	ENSGALG00000016854	LIG4	100	75.983	Gallus_gallus
ENSG00000174405	LIG4	99	66.074	ENSGAFG00000019779	lig4	95	65.604	Gambusia_affinis
ENSG00000174405	LIG4	100	64.218	ENSGACG00000014135	lig4	99	63.787	Gasterosteus_aculeatus
ENSG00000174405	LIG4	100	99.763	ENSGGOG00000027771	LIG4	100	99.671	Gorilla_gorilla
ENSG00000174405	LIG4	99	66.311	ENSHBUG00000006245	lig4	99	65.787	Haplochromis_burtoni
ENSG00000174405	LIG4	100	89.791	ENSHGLG00000000718	LIG4	100	89.791	Heterocephalus_glaber_female
ENSG00000174405	LIG4	100	89.791	ENSHGLG00100003265	LIG4	100	89.791	Heterocephalus_glaber_male
ENSG00000174405	LIG4	100	65.758	ENSHCOG00000012010	lig4	99	64.835	Hippocampus_comes
ENSG00000174405	LIG4	100	65.799	ENSIPUG00000013748	lig4	99	65.313	Ictalurus_punctatus
ENSG00000174405	LIG4	100	90.450	ENSSTOG00000024303	LIG4	100	90.450	Ictidomys_tridecemlineatus
ENSG00000174405	LIG4	100	87.816	ENSJJAG00000006750	Lig4	100	87.816	Jaculus_jaculus
ENSG00000174405	LIG4	100	65.758	ENSKMAG00000001149	lig4	99	65.670	Kryptolebias_marmoratus
ENSG00000174405	LIG4	99	66.346	ENSLBEG00000014578	lig4	100	66.587	Labrus_bergylta
ENSG00000174405	LIG4	100	72.630	ENSLACG00000003282	LIG4	99	72.677	Latimeria_chalumnae
ENSG00000174405	LIG4	100	71.513	ENSLOCG00000008901	lig4	98	70.833	Lepisosteus_oculatus
ENSG00000174405	LIG4	100	88.061	ENSLAFG00000031152	LIG4	100	88.061	Loxodonta_africana
ENSG00000174405	LIG4	100	97.512	ENSMFAG00000037235	LIG4	100	97.366	Macaca_fascicularis
ENSG00000174405	LIG4	100	97.512	ENSMMUG00000008874	LIG4	100	97.366	Macaca_mulatta
ENSG00000174405	LIG4	100	97.512	ENSMNEG00000023575	LIG4	100	97.366	Macaca_nemestrina
ENSG00000174405	LIG4	100	97.156	ENSMLEG00000026720	LIG4	100	97.036	Mandrillus_leucophaeus
ENSG00000174405	LIG4	100	67.299	ENSMAMG00000008472	lig4	99	66.593	Mastacembelus_armatus
ENSG00000174405	LIG4	99	66.548	ENSMZEG00005001855	lig4	99	66.007	Maylandia_zebra
ENSG00000174405	LIG4	100	76.659	ENSMGAG00000015532	LIG4	99	76.619	Meleagris_gallopavo
ENSG00000174405	LIG4	100	84.632	ENSMOCG00000019000	Lig4	100	84.632	Microtus_ochrogaster
ENSG00000174405	LIG4	100	65.995	ENSMMOG00000004390	lig4	99	65.670	Mola_mola
ENSG00000174405	LIG4	100	84.479	ENSMODG00000025064	LIG4	100	84.649	Monodelphis_domestica
ENSG00000174405	LIG4	100	66.706	ENSMALG00000008555	lig4	99	66.224	Monopterus_albus
ENSG00000174405	LIG4	100	87.267	MGP_CAROLIEiJ_G0030809	Lig4	100	87.267	Mus_caroli
ENSG00000174405	LIG4	100	87.047	ENSMUSG00000049717	Lig4	100	87.047	Mus_musculus
ENSG00000174405	LIG4	100	87.047	MGP_PahariEiJ_G0021270	Lig4	100	87.047	Mus_pahari
ENSG00000174405	LIG4	100	87.047	MGP_SPRETEiJ_G0031917	Lig4	100	87.047	Mus_spretus
ENSG00000174405	LIG4	100	89.023	ENSMPUG00000018675	LIG4	100	89.023	Mustela_putorius_furo
ENSG00000174405	LIG4	100	91.109	ENSMLUG00000001267	LIG4	100	91.109	Myotis_lucifugus
ENSG00000174405	LIG4	100	87.267	ENSNGAG00000013258	Lig4	100	87.267	Nannospalax_galili
ENSG00000174405	LIG4	99	66.785	ENSNBRG00000021252	lig4	99	66.227	Neolamprologus_brichardi
ENSG00000174405	LIG4	100	97.630	ENSNLEG00000007888	LIG4	100	97.585	Nomascus_leucogenys
ENSG00000174405	LIG4	100	88.474	ENSOPRG00000005765	LIG4	100	88.474	Ochotona_princeps
ENSG00000174405	LIG4	100	87.706	ENSODEG00000019683	LIG4	100	87.706	Octodon_degus
ENSG00000174405	LIG4	99	66.429	ENSONIG00000011969	lig4	98	66.117	Oreochromis_niloticus
ENSG00000174405	LIG4	100	91.438	ENSOCUG00000015734	LIG4	100	91.438	Oryctolagus_cuniculus
ENSG00000174405	LIG4	100	65.485	ENSORLG00000004041	lig4	99	64.835	Oryzias_latipes
ENSG00000174405	LIG4	100	65.603	ENSORLG00020019607	lig4	99	65.165	Oryzias_latipes_hni
ENSG00000174405	LIG4	100	65.603	ENSORLG00015017754	lig4	99	64.945	Oryzias_latipes_hsok
ENSG00000174405	LIG4	73	71.753	ENSOMEG00000003459	lig4	98	70.562	Oryzias_melastigma
ENSG00000174405	LIG4	100	91.886	ENSOGAG00000032120	LIG4	99	91.886	Otolemur_garnettii
ENSG00000174405	LIG4	82	90.872	ENSOARG00000005590	LIG4	98	90.872	Ovis_aries
ENSG00000174405	LIG4	100	99.341	ENSPPAG00000032998	LIG4	100	99.341	Pan_paniscus
ENSG00000174405	LIG4	100	90.340	ENSPPRG00000017804	LIG4	100	90.340	Panthera_pardus
ENSG00000174405	LIG4	100	90.231	ENSPTIG00000010051	LIG4	100	90.231	Panthera_tigris_altaica
ENSG00000174405	LIG4	100	99.451	ENSPTRG00000006025	LIG4	100	99.451	Pan_troglodytes
ENSG00000174405	LIG4	100	97.512	ENSPANG00000007562	LIG4	100	97.256	Papio_anubis
ENSG00000174405	LIG4	100	67.654	ENSPKIG00000011645	lig4	98	66.959	Paramormyrops_kingsleyae
ENSG00000174405	LIG4	100	79.858	ENSPSIG00000001504	LIG4	99	79.231	Pelodiscus_sinensis
ENSG00000174405	LIG4	100	64.379	ENSPMGG00000013486	lig4	99	63.447	Periophthalmus_magnuspinnatus
ENSG00000174405	LIG4	100	87.171	ENSPEMG00000000076	Lig4	100	87.171	Peromyscus_maniculatus_bairdii
ENSG00000174405	LIG4	100	84.615	ENSPCIG00000021882	LIG4	100	84.430	Phascolarctos_cinereus
ENSG00000174405	LIG4	100	66.351	ENSPFOG00000000797	lig4	99	65.604	Poecilia_formosa
ENSG00000174405	LIG4	100	66.232	ENSPLAG00000001196	lig4	99	65.495	Poecilia_latipinna
ENSG00000174405	LIG4	100	66.351	ENSPMEG00000021353	lig4	99	65.714	Poecilia_mexicana
ENSG00000174405	LIG4	100	66.114	ENSPREG00000007323	lig4	99	65.275	Poecilia_reticulata
ENSG00000174405	LIG4	100	98.341	ENSPPYG00000005540	LIG4	100	98.244	Pongo_abelii
ENSG00000174405	LIG4	100	90.889	ENSPVAG00000016403	LIG4	100	90.889	Pteropus_vampyrus
ENSG00000174405	LIG4	99	66.429	ENSPNYG00000009660	lig4	99	65.897	Pundamilia_nyererei
ENSG00000174405	LIG4	100	65.403	ENSPNAG00000028056	lig4	100	64.803	Pygocentrus_nattereri
ENSG00000174405	LIG4	100	65.403	ENSPNAG00000028069	LIG4	100	64.803	Pygocentrus_nattereri
ENSG00000174405	LIG4	100	86.169	ENSRNOG00000014605	Lig4	100	86.169	Rattus_norvegicus
ENSG00000174405	LIG4	99	97.031	ENSRBIG00000039962	LIG4	100	95.719	Rhinopithecus_bieti
ENSG00000174405	LIG4	100	96.801	ENSRROG00000006040	LIG4	100	96.707	Rhinopithecus_roxellana
ENSG00000174405	LIG4	100	95.060	ENSSBOG00000019029	LIG4	100	95.060	Saimiri_boliviensis_boliviensis
ENSG00000174405	LIG4	100	80.687	ENSSHAG00000009525	LIG4	100	81.250	Sarcophilus_harrisii
ENSG00000174405	LIG4	100	66.706	ENSSFOG00015012835	lig4	100	65.721	Scleropages_formosus
ENSG00000174405	LIG4	100	64.692	ENSSMAG00000011267	lig4	99	64.230	Scophthalmus_maximus
ENSG00000174405	LIG4	100	67.773	ENSSDUG00000010343	lig4	98	67.295	Seriola_dumerili
ENSG00000174405	LIG4	100	65.877	ENSSLDG00000003239	lig4	99	65.385	Seriola_lalandi_dorsalis
ENSG00000174405	LIG4	100	83.707	ENSSARG00000006573	LIG4	100	83.589	Sorex_araneus
ENSG00000174405	LIG4	100	77.725	ENSSPUG00000002444	LIG4	100	77.725	Sphenodon_punctatus
ENSG00000174405	LIG4	100	66.706	ENSSPAG00000001609	lig4	99	65.934	Stegastes_partitus
ENSG00000174405	LIG4	100	88.863	ENSSSCG00000009540	LIG4	100	88.804	Sus_scrofa
ENSG00000174405	LIG4	100	75.711	ENSTGUG00000010795	LIG4	99	75.996	Taeniopygia_guttata
ENSG00000174405	LIG4	100	66.351	ENSTRUG00000009984	lig4	99	65.714	Takifugu_rubripes
ENSG00000174405	LIG4	100	66.114	ENSTNIG00000010348	lig4	99	65.824	Tetraodon_nigroviridis
ENSG00000174405	LIG4	100	91.438	ENSTBEG00000017741	LIG4	100	91.438	Tupaia_belangeri
ENSG00000174405	LIG4	100	89.572	ENSTTRG00000012660	LIG4	100	89.572	Tursiops_truncatus
ENSG00000174405	LIG4	100	89.336	ENSUAMG00000003773	LIG4	100	89.243	Ursus_americanus
ENSG00000174405	LIG4	100	73.934	ENSXETG00000002654	lig4	99	73.238	Xenopus_tropicalis
ENSG00000174405	LIG4	100	65.995	ENSXCOG00000017401	lig4	99	65.165	Xiphophorus_couchianus
ENSG00000174405	LIG4	100	66.391	ENSXMAG00000015142	lig4	99	65.423	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000012	single strand break repair	8798671.	IDA	Process
GO:0000784	nuclear chromosome, telomeric region	23275564.	IC	Component
GO:0000793	condensed chromosome	12589063.	IDA	Component
GO:0001701	in utero embryonic development	-	ISS	Process
GO:0002328	pro-B cell differentiation	-	ISS	Process
GO:0003677	DNA binding	8798671.	IDA	Function
GO:0003909	DNA ligase activity	12517771.	IDA	Function
GO:0003909	DNA ligase activity	-	TAS	Function
GO:0003910	DNA ligase (ATP) activity	8798671.22192310.	IDA	Function
GO:0005515	protein binding	9242410.9259561.9809069.11702069.16439205.17389648.17396150.21070942.22529269.22658747.23178593.23219551.25416956.25910212.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	8798671.12589063.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	21873635.	IBA	Component
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	15194694.	IDA	Component
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	-	ISS	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006266	DNA ligation	12517771.	IDA	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	21873635.	IBA	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	12517771.	IDA	Process
GO:0006302	double-strand break repair	9242410.19589734.	IDA	Process
GO:0006302	double-strand break repair	-	ISS	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	12517771.	IDA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	23275564.	IGI	Process
GO:0006303	double-strand break repair via nonhomologous end joining	9809069.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	ISS	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007417	central nervous system development	-	ISS	Process
GO:0008022	protein C-terminus binding	12589063.	IPI	Function
GO:0008283	cell proliferation	-	ISS	Process
GO:0010165	response to X-ray	9809069.	IMP	Process
GO:0010332	response to gamma radiation	-	ISS	Process
GO:0016874	ligase activity	9242410.	IDA	Function
GO:0032807	DNA ligase IV complex	21873635.	IBA	Component
GO:0032807	DNA ligase IV complex	9809069.	IMP	Component
GO:0033077	T cell differentiation in thymus	-	ISS	Process
GO:0033151	V(D)J recombination	9809069.	IDA	Process
GO:0033152	immunoglobulin V(D)J recombination	21873635.	IBA	Process
GO:0033153	T cell receptor V(D)J recombination	-	ISS	Process
GO:0035019	somatic stem cell population maintenance	-	ISS	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0043524	negative regulation of neuron apoptotic process	-	ISS	Process
GO:0045190	isotype switching	-	ISS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048146	positive regulation of fibroblast proliferation	-	ISS	Process
GO:0050769	positive regulation of neurogenesis	-	ISS	Process
GO:0051102	DNA ligation involved in DNA recombination	-	ISS	Process
GO:0051103	DNA ligation involved in DNA repair	12517771.	IDA	Process
GO:0051103	DNA ligation involved in DNA repair	-	ISS	Process
GO:0051276	chromosome organization	-	ISS	Process
GO:0051301	cell division	-	IEA	Process
GO:0051402	neuron apoptotic process	-	ISS	Process
GO:0070419	nonhomologous end joining complex	20383123.25941166.	IDA	Component
GO:0071285	cellular response to lithium ion	-	IEA	Process
GO:0071479	cellular response to ionizing radiation	29463814.	IGI	Process
GO:0071897	DNA biosynthetic process	-	IEA	Process
GO:0075713	establishment of integrated proviral latency	-	TAS	Process
GO:0097680	double-strand break repair via classical nonhomologous end joining	24837021.	IMP	Process
GO:2001252	positive regulation of chromosome organization	23275564.	IMP	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.