EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25203323The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.Cancer Cell2014 Sep 8Wang Ydoi: 10.1016/j.ccr.2014.07.010.
16934801WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.Exp Cell Res2006 Oct 15Markus MA-
26506517The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.Oncotarget2015 Nov 10Liang YCdoi: 10.18632/oncotarget.5710.
25140042Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.RNA2014 OctLin JCdoi: 10.1261/rna.045583.114
19416963Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation.J Biol Chem2009 Jul 3Brooks YSdoi: 10.1074/jbc.M109.006999
28754317Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4.Int J Biochem Cell Biol2017 SepHuang GWdoi: 10.1016/j.biocel.2017.07.017
29138007RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.Biochim Biophys Acta Mol Cell Res2018 FebLin JCdoi: 10.1016/j.bbamcr.2017.11.005
27324405Prognostic value of decreased expression of RBM4 in human gastric cancer.Sci Rep2016 Jun 21Yong Hdoi: 10.1038/srep28222.
28276498The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells.Sci Rep2017 Mar 9Lin JCdoi: 10.1038/srep44204.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1166639924SilentnovelK71K0.26
BLCAchr1166643527SilentNAR164R0.12
BLCAchr1166644082Missense_MutationnovelR349G0.1
BRCAchr1166644187Intronnovel0.19
BRCAchr1166639750SilentNAA13A0.17
BRCAchr1166644420Intronnovel0.17
BRCAchr1166643757Silentrs372104227S240S0.1
BRCAchr1166639997Missense_MutationnovelA96T0.09zf-CCHC
BRCAchr1166643514Missense_MutationNAQ159H0.3
CESCchr1166639628Intronnovel0.1
CESCchr1166640038SilentnovelI109I0.28
CESCchr1166643758Missense_Mutationrs752990000V241M0.31
CESCchr1166639636Intronnovel0.31
CESCchr11666460843'UTRnovel0.4
CHOLchr1166643474Missense_MutationnovelS146F0.42
CHOLchr1166639937Missense_MutationnovelT76P0.07
COADchr1166639869Missense_Mutationrs765301901R53H0.38
COADchr1166639591Intronnovel0.33
COADchr1166643793SilentNAL252L0.49
COADchr1166643901Silentrs746731288A288A0.27
COADchr1166639598Intronnovel0.67
COADchr1166644192Intronnovel0.28
COADchr1166643587Missense_MutationNAA184T0.46
COADchr1166643950Missense_Mutationrs767778848G305R0.32
COADchr1166639956Missense_MutationnovelV82A0.35zf-CCHC
COADchr1166640070Missense_MutationnovelR120Q0.13zf-CCHC
COADchr1166639511Intronnovel0.09
COADchr1166639513Intronnovel0.09
COADchr1166639693Splice_Regionnovel0.12
COADchr1166639640Intronnovel0.38
COADchr1166644083Missense_MutationNAR349Q0.28
DLBCchr1166643848Missense_Mutationrs767766638P271S0.14
ESCAchr1166639663Intronnovel0.35
ESCAchr1166639760Missense_MutationnovelE17Q0.4
ESCAchr1166643630Missense_Mutationrs577949918R198H0.38
ESCAchr11666461003'UTRnovel0.45
GBMchr1166643994Silentrs777485002P319P0.41
GBMchr1166640017SilentNAG102G0.07
GBMchr1166644056Missense_Mutationrs766435416A340V0.7
GBMchr1166643495Missense_MutationNAA153V0.39
HNSCchr1166639869Missense_Mutationrs765301901R53H0.31
HNSCchr1166643565Silentrs373465062P176P0.07
HNSCchr1166640232Intronnovel0.18
HNSCchr1166640234Intronnovel0.18
HNSCchr1166640006Missense_MutationnovelE99Q0.24zf-CCHC
HNSCchr1166639876SilentnovelL55L0.11
HNSCchr1166643767Missense_MutationnovelY244H0.21
KIRPchr1166643979SilentNAA314A0.38
LAMLchr1166643743Missense_MutationnovelA236T0.1
LGGchr1166640175Intronnovel0.13
LGGchr1166643563Frame_Shift_InsnovelS180*0.44
LIHCchr1166643757Silentrs372104227S240S0.52
LUADchr1166639569Intronnovel0.31
LUADchr1166643845Missense_Mutationrs751773381D270N0.11
LUADchr1166644148Splice_Regionnovel0.47
LUADchr1166640219Intronnovel0.67
LUADchr1166644130Nonstop_Mutationnovel*365Kext*750.34
LUADchr1166643583Silentrs751146254R182R0.21
LUADchr1166640057Missense_MutationNAV116L0.1zf-CCHC
LUADchr1166640261Intronnovel0.21
LUADchr1166643938Missense_MutationnovelT301S0.8
LUSCchr1166639668Intronnovel0.48
LUSCchr1166643943SilentNAS302S0.21
LUSCchr1166643893In_Frame_Delrs773057844A289_A295del0.34
LUSCchr1166639780SilentnovelE23E0.2
OVchr1166640273Intronnovel0.12
OVchr1166640136Intronnovel0.47
OVchr1166643798Missense_MutationnovelQ254R0.07
OVchr1166644112Missense_MutationNAA359T0.23
READchr1166643456Missense_MutationNAR140Q0.15
READchr1166640038SilentNAI109I0.17
READchr1166639668Intronnovel0.41
READchr1166639994Nonsense_MutationNAR95*0.45zf-CCHC
READchr1166640388Intronnovel0.5
READchr1166639801Missense_MutationNAE30D0.32
SARCchr1166644058Missense_MutationnovelR341G0.09
SARCchr11666461843'UTRnovel0.09
SARCchr1166644127Missense_MutationnovelF364L0.08
SKCMchr1166644161Intronnovel0.75
SKCMchr1166639970Missense_MutationnovelP87S0.38zf-CCHC
SKCMchr1166643802SilentnovelV255V0.42
SKCMchr1166644180Intronnovel0.38
SKCMchr1166643474Missense_MutationnovelS146F0.45
STADchr1166640017SilentNAG102G0.1
STADchr1166643494Missense_MutationNAA153T0.19
STADchr1166643499SilentNAP154P0.11
STADchr1166643904SilentNAA289A0.29
STADchr1166643722Missense_MutationNAR229W0.35
STADchr1166643629Missense_Mutationrs748197738R198C0.28
STADchr1166643696Missense_MutationNAA220V0.18
STADchr1166640057Missense_Mutationrs368114061V116I0.23zf-CCHC
STADchr1166643723Missense_Mutationrs768616980R229Q0.19
STADchr1166643704Missense_MutationNAK223E0.21
TGCTchr1166643715SilentnovelR226R0.22
THCAchr1166640126Splice_RegionNA0.13
UCECchr1166644118Missense_MutationNAY361H0.13
UCECchr1166643863Missense_MutationnovelL276M0.39
UCECchr11666461033'UTRnovel0.06
UCECchr1166643949Silentrs777866630Y304Y0.44
UCECchr1166644056Missense_MutationnovelA340G0.18
UCECchr1166643912Missense_MutationnovelA292V0.43
UCECchr1166643714Missense_MutationnovelR226H0.38
UCECchr1166639860Missense_MutationnovelD50G0.1
UCECchr1166639588Intronnovel0.31
UCECchr1166639849SilentNAT46T0.13
UCECchr1166640038SilentNAI109I0.09
UCECchr1166643914Missense_Mutationrs763486340A293T0.48
UCECchr11666461973'UTRnovel0.29
UCECchr1166640111Missense_MutationnovelT134P0.5zf-CCHC
UCECchr1166643914Missense_Mutationrs763486340A293T0.42
UCECchr1166643766SilentNAN243N0.37
UCECchr1166639903SilentnovelN64N0.11
UCECchr1166639987SilentnovelK92K0.05
UCECchr1166643949Silentrs777866630Y304Y0.24
UCECchr1166640291Intronnovel0.19
UCECchr1166639766Missense_MutationNAR19C0.3
UCECchr1166639994Nonsense_MutationNAR95*0.3zf-CCHC
UCECchr1166643565Silentrs373465062P176P0.27
UCECchr1166643890Missense_MutationnovelT285A0.36
UCECchr1166640026SilentnovelI105I0.14
UCECchr1166639615Intronnovel0.29
UCECchr1166643527Missense_MutationNAR164W0.13
UCECchr11666463553'UTRnovel0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.25540.018342
TGCTDEL0.70.21504

Survival Analysis
CancerP-value Q-value
ACC0.0054

Kaplan-Meier Survival Analysis

UCS0.03

Kaplan-Meier Survival Analysis

PRAD0.031

Kaplan-Meier Survival Analysis

PCPG0.014

Kaplan-Meier Survival Analysis

BLCA0.0094

Kaplan-Meier Survival Analysis

READ0.022

Kaplan-Meier Survival Analysis

LAML0.00033

Kaplan-Meier Survival Analysis

KICH0.016

Kaplan-Meier Survival Analysis

UCEC0.016

Kaplan-Meier Survival Analysis

GBM0.033

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.049

Kaplan-Meier Survival Analysis

UVM0.0087

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000173933 (Gene tree)
Gene ID
5936
Gene Symbol
RBM4
Alias
LARK|RBM4A|ZCRB3A|ZCCHC21
Full Name
RNA binding motif protein 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
29,769 bases
Position
chr11:66,638,617-66,668,385
Accession
9901
RBP type
canonical RBP
Summary
(RNA Binding Motif Protein 4) is a Protein Coding gene. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM4B.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000309166zf-CCHCPF00098.236.7e-0711
ENSP00000386561zf-CCHCPF00098.236.7e-0711
ENSP00000386894zf-CCHCPF00098.236.7e-0711
ENSP00000422301RRM_5PF13893.63.6e-0812
ENSP00000422301RRM_5PF13893.63.6e-0822
ENSP00000309166RRM_5PF13893.61.4e-0712
ENSP00000309166RRM_5PF13893.61.4e-0722
ENSP00000386561RRM_5PF13893.61.4e-0712
ENSP00000386561RRM_5PF13893.61.4e-0722
ENSP00000386894RRM_5PF13893.61.4e-0712
ENSP00000386894RRM_5PF13893.61.4e-0722
ENSP00000413497RRM_5PF13893.63.5e-0611
ENSP00000423572RRM_5PF13893.63.8e-0611
ENSP00000381680RRM_5PF13893.66.1e-0611
ENSP00000432150RRM_5PF13893.66.1e-0611
ENSP00000432020RRM_5PF13893.66.4e-0611
ENSP00000435821RRM_5PF13893.66.4e-0611
ENSP00000464349RRM_5PF13893.61.4e-0511
ENSP00000422301RRM_1PF00076.222.2e-3412
ENSP00000422301RRM_1PF00076.222.2e-3422
ENSP00000413497RRM_1PF00076.223.4e-3412
ENSP00000413497RRM_1PF00076.223.4e-3422
ENSP00000381680RRM_1PF00076.225.3e-3412
ENSP00000381680RRM_1PF00076.225.3e-3422
ENSP00000432150RRM_1PF00076.225.3e-3412
ENSP00000432150RRM_1PF00076.225.3e-3422
ENSP00000432020RRM_1PF00076.226e-3412
ENSP00000432020RRM_1PF00076.226e-3422
ENSP00000435821RRM_1PF00076.226e-3412
ENSP00000435821RRM_1PF00076.226e-3422
ENSP00000309166RRM_1PF00076.226.9e-3412
ENSP00000309166RRM_1PF00076.226.9e-3422
ENSP00000386561RRM_1PF00076.226.9e-3412
ENSP00000386561RRM_1PF00076.226.9e-3422
ENSP00000386894RRM_1PF00076.226.9e-3412
ENSP00000386894RRM_1PF00076.226.9e-3422
ENSP00000423572RRM_1PF00076.229.5e-3412
ENSP00000423572RRM_1PF00076.229.5e-3422
ENSP00000464349RRM_1PF00076.222.2e-3312
ENSP00000464349RRM_1PF00076.222.2e-3322
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
14528909Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome.Cell Mol Biol (Noisy-le-grand)2003 JulGulesserian T-
23129807RBM4 promotes pancreas cell differentiation and insulin expression.Mol Cell Biol2013 JanLin JCdoi: 10.1128/MCB.01266-12
23897118MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.Immunol Cell Biol2013 SepBrudecki Ldoi: 10.1038/icb.2013.37
17068759Identification and analysis of altered alpha1,6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis.Proteomics2006 NovDai Z-
26216489Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.Tissue Antigens2015 SepYamada Edoi: 10.1111/tan.12607
28754317Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4.Int J Biochem Cell Biol2017 SepHuang GWdoi: 10.1016/j.biocel.2017.07.017
16212419Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).J Proteome Res2005 Sep-OctAmanchy R-
12628928A novel splicing regulator shares a nuclear import pathway with SR proteins.EMBO J2003 Mar 17Lai MC-
16260624Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.Mol Cell Biol2005 NovLin JC-
16777844RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.J Biol Chem2006 Aug 25Kar A-
19801630RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.J Biol Chem2009 Dec 11Lin JCdoi: 10.1074/jbc.M109.032946
18708123The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.Neurosci Lett2008 Oct 17Pfuhl Tdoi: 10.1016/j.neulet.2008.08.017
18064391Gene expression profiling in apoptotic k562 cells treated by homoharringtonine.Acta Biochim Biophys Sin (Shanghai)2007 DecJin W-
17932509Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.EMBO Rep2007 NovHock J-
17284590Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.Proc Natl Acad Sci U S A2007 Feb 13Lin JC-
25414336Alanine repeats influence protein localization in splicing speckles and paraspeckles.Nucleic Acids Res2014 Dec 16Chang SHdoi: 10.1093/nar/gku1159
25140042Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.RNA2014 OctLin JCdoi: 10.1261/rna.045583.114
24389249Emerging role for RNA binding motif protein 4 in the development of brown adipocytes.Biochim Biophys Acta2014 AprLin JCdoi: 10.1016/j.bbamcr.2013.12.018
26506517The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.Oncotarget2015 Nov 10Liang YCdoi: 10.18632/oncotarget.5710.
25998849Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.J Innate Immun2015McClure Cdoi: 10.1159/000381915
29138007RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.Biochim Biophys Acta Mol Cell Res2018 FebLin JCdoi: 10.1016/j.bbamcr.2017.11.005
30200638RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.Int J Mol Sci2018 Sep 6Peng HYdoi: 10.3390/ijms19092646.
18723113RBM4: a multifunctional RNA-binding protein.Int J Biochem Cell Biol2009 AprMarkus MAdoi: 10.1016/j.biocel.2008.05.027
28138257Decrease of RBM4 indicates poor prognosis in patients with hepatocellular carcinoma after hepatectomy.Onco Targets Ther2017 Jan 11Chen JYdoi: 10.2147/OTT.S125250
22678294An oxygen-regulated switch in the protein synthesis machinery.Nature2012 May 6Uniacke Jdoi: 10.1038/nature11055.
22202052Multiple roles of RBM4 in muscle cell differentiation.Front Biosci (Schol Ed)2012 Jan 1Lin JC-
21562054MicroRNA-146a regulates both transcription silencing and translation disruption of TNF--and-alpha; during TLR4-induced gene reprogramming.J Leukoc Biol2011 SepEl Gazzar Mdoi: 10.1189/jlb.0211074
21518792RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.J Cell Biol2011 May 2Lin JCdoi: 10.1083/jcb.201007131
25211129Translational regulation of the DOUBLETIME/CKIdelta/-epsilon kinase by LARK contributes to circadian period modulation.PLoS Genet2014 Sep 11Huang Ydoi: 10.1371/journal.pgen.1004536
27662615Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements.PLoS Genet2016 Sep 23Swain Adoi: 10.1371/journal.pgen.1006331
23825193Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes.Clin Vaccine Immunol2013 SepBrudecki Ldoi: 10.1128/CVI.00264-13
23527094Phylogenetic and molecular characterization of the splicing factor RBM4.PLoS One2013Lu CCdoi: 10.1371/journal.pone.0059092
26857472RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes.Sci Rep2016 Feb 9Lin JCdoi: 10.1038/srep20665.
27324405Prognostic value of decreased expression of RBM4 in human gastric cancer.Sci Rep2016 Jun 21Yong Hdoi: 10.1038/srep28222.
26565589A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.Elife2015 Nov 13Gowen BGdoi: 10.7554/eLife.08474.
29581187RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.Mol Cell Biol2018 May 29D Ddoi: 10.1128/MCB.00007-18
31145716RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer.Med Sci Monit2019 May 30Yong Hdoi: 10.12659/MSM.914513.
31234575Berberine Promotes Beige Adipogenic Signatures of 3T3-L1 Cells by Regulating Post-transcriptional Events.Cells2019 Jun 23Lin YCdoi: 10.3390/cells8060632.
20617199RNAcontext: a new method for learning the sequence and structure binding preferences of RNA-binding proteins.PLoS Comput Biol2010 Jul 1Kazan Hdoi: 10.1371/journal.pcbi.1000832.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000398692RBM4-203921-ENSP00000381680143 (aa)-Q9BWF3
ENST00000310092RBM4-2011694-ENSP00000309166364 (aa)-Q9BWF3
ENST00000578778RBM4-213582-ENSP00000464349155 (aa)-J3QRR5
ENST00000510173RBM4-208782-ENSP00000422301240 (aa)-E9PB51
ENST00000396053RBM4-2023029-ENSP00000413497173 (aa)-Q9BWF3
ENST00000532968RBM4-212757-ENSP00000432020177 (aa)-Q9BWF3
ENST00000506523RBM4-207654-ENSP00000423572150 (aa)-D6R9K7
ENST00000409406RBM4-2052321-ENSP00000386894364 (aa)-Q9BWF3
ENST00000408993RBM4-2041763-ENSP00000386561364 (aa)-Q9BWF3
ENST00000530235RBM4-2111011-ENSP00000432150143 (aa)-Q9BWF3
ENST00000528039RBM4-210764--- (aa)--
ENST00000515838RBM4-209943--- (aa)--
ENST00000483858RBM4-2061548-ENSP00000435821177 (aa)-Q9BWF3
Gene Model
Click here to download ENSG00000173933's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173933's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000173933RBM49830.625ENSG00000116001TIA18531.081
ENSG00000173933RBM49730.128ENSG00000101489CELF45230.065
ENSG00000173933RBM48838.983ENSG00000115875SRSF78335.780
ENSG00000173933RBM49798.551ENSG00000173914RBM4B9897.857
ENSG00000173933RBM47735.714ENSG00000147140NONO6032.857
ENSG00000173933RBM45033.750ENSG00000213516RBMXL19133.750
ENSG00000173933RBM49030.464ENSG00000135486HNRNPA16530.464
ENSG00000173933RBM49431.034ENSG00000151923TIAL18430.973
ENSG00000173933RBM45932.143ENSG00000124193SRSF66232.143
ENSG00000173933RBM49748.529ENSG00000239306RBM149448.529
ENSG00000173933RBM47730.952ENSG00000149187CELF17933.333
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000173933RBM4100100.000ENSAMEG00000010914RBM410099.178Ailuropoda_melanoleuca
ENSG00000173933RBM410098.780ENSAMEG00000010906RBM4B9698.780Ailuropoda_melanoleuca
ENSG00000173933RBM410096.129ENSANAG00000023478RBM4B10096.129Aotus_nancymaae
ENSG00000173933RBM410096.503ENSANAG00000033986-9688.679Aotus_nancymaae
ENSG00000173933RBM49798.551ENSBTAG00000000423RBM4B9698.780Bos_taurus
ENSG00000173933RBM410097.253ENSBTAG00000031688RBM410097.253Bos_taurus
ENSG00000173933RBM410096.774ENSCJAG00000013666RBM4B10096.774Callithrix_jacchus
ENSG00000173933RBM4100100.000ENSCAFG00000012388RBM410099.178Canis_familiaris
ENSG00000173933RBM410098.780ENSCAFG00000012378RBM4B9698.780Canis_familiaris
ENSG00000173933RBM410098.780ENSCAFG00020015519RBM4B9698.780Canis_lupus_dingo
ENSG00000173933RBM4100100.000ENSCAFG00020015515RBM410099.178Canis_lupus_dingo
ENSG00000173933RBM410097.253ENSCHIG00000020613RBM410097.253Capra_hircus
ENSG00000173933RBM49798.551ENSCHIG00000008907RBM4B9698.780Capra_hircus
ENSG00000173933RBM46679.583ENSTSYG00000009580RBM4B9679.668Carlito_syrichta
ENSG00000173933RBM49487.850ENSTSYG00000036168-10082.400Carlito_syrichta
ENSG00000173933RBM410099.301ENSCAPG00000016600RBM410099.301Cavia_aperea
ENSG00000173933RBM49798.551ENSCAPG00000009570RBM4B9698.780Cavia_aperea
ENSG00000173933RBM410099.301ENSCPOG00000013194RBM410099.301Cavia_porcellus
ENSG00000173933RBM49798.551ENSCPOG00000013689RBM4B9698.780Cavia_porcellus
ENSG00000173933RBM49798.551ENSCCAG00000016501RBM4B9897.857Cebus_capucinus
ENSG00000173933RBM49972.535ENSCCAG00000023319-10074.129Cebus_capucinus
ENSG00000173933RBM410097.203ENSCCAG00000007508-10097.203Cebus_capucinus
ENSG00000173933RBM49798.551ENSCATG00000035353RBM4B9897.857Cercocebus_atys
ENSG00000173933RBM410099.301ENSCLAG00000014756RBM410099.301Chinchilla_lanigera
ENSG00000173933RBM410098.780ENSCLAG00000015287RBM4B9698.780Chinchilla_lanigera
ENSG00000173933RBM49798.551ENSCSAG00000008361RBM4B9698.780Chlorocebus_sabaeus
ENSG00000173933RBM49798.551ENSCHOG00000002892RBM4B9698.780Choloepus_hoffmanni
ENSG00000173933RBM46297.357ENSCHOG00000009753RBM14-RBM410097.357Choloepus_hoffmanni
ENSG00000173933RBM410096.341ENSCPBG00000023800-10074.278Chrysemys_picta_bellii
ENSG00000173933RBM49798.551ENSCANG00000021868RBM4B9897.857Colobus_angolensis_palliatus
ENSG00000173933RBM410098.601ENSCGRG00001016609-10098.601Cricetulus_griseus_chok1gshd
ENSG00000173933RBM49798.551ENSCGRG00001024693Rbm4b9698.780Cricetulus_griseus_chok1gshd
ENSG00000173933RBM49798.551ENSCGRG00000012112Rbm4b9698.780Cricetulus_griseus_crigri
ENSG00000173933RBM410098.601ENSCGRG00000010183-10098.601Cricetulus_griseus_crigri
ENSG00000173933RBM49798.551ENSDNOG00000019500-9698.780Dasypus_novemcinctus
ENSG00000173933RBM410099.390ENSDNOG00000032390RBM410098.630Dasypus_novemcinctus
ENSG00000173933RBM410097.561ENSDNOG00000045639-9697.561Dasypus_novemcinctus
ENSG00000173933RBM49798.551ENSDORG00000029108Rbm4b9698.780Dipodomys_ordii
ENSG00000173933RBM410098.171ENSDORG00000004538-10097.902Dipodomys_ordii
ENSG00000173933RBM46263.717ENSETEG00000018142-10064.159Echinops_telfairi
ENSG00000173933RBM410098.780ENSEASG00005005068RBM4B9698.780Equus_asinus_asinus
ENSG00000173933RBM4100100.000ENSEASG00005005064RBM410097.802Equus_asinus_asinus
ENSG00000173933RBM410098.780ENSECAG00000022987RBM4B9698.780Equus_caballus
ENSG00000173933RBM4100100.000ENSECAG00000022940RBM410097.802Equus_caballus
ENSG00000173933RBM49799.275ENSEEUG00000000058RBM4B9699.390Erinaceus_europaeus
ENSG00000173933RBM49798.551ENSFCAG00000007394RBM4B9897.857Felis_catus
ENSG00000173933RBM4100100.000ENSFCAG00000029651RBM4100100.000Felis_catus
ENSG00000173933RBM49797.101ENSFALG00000002073-10068.108Ficedula_albicollis
ENSG00000173933RBM410098.780ENSFDAG00000015530RBM4B9698.780Fukomys_damarensis
ENSG00000173933RBM49992.366ENSFDAG00000013661-9692.366Fukomys_damarensis
ENSG00000173933RBM410099.301ENSFDAG00000005447RBM410099.301Fukomys_damarensis
ENSG00000173933RBM49797.101ENSGALG00000037946-10076.000Gallus_gallus
ENSG00000173933RBM49797.101ENSGALG00000040489-8695.745Gallus_gallus
ENSG00000173933RBM410096.341ENSGAGG00000008553-10074.607Gopherus_agassizii
ENSG00000173933RBM49878.571ENSGGOG00000043023-9879.562Gorilla_gorilla
ENSG00000173933RBM410095.804ENSGGOG00000011698RBM4B9897.857Gorilla_gorilla
ENSG00000173933RBM49765.942ENSHGLG00000000117-9566.027Heterocephalus_glaber_female
ENSG00000173933RBM410085.976ENSHGLG00000002853-9985.976Heterocephalus_glaber_female
ENSG00000173933RBM410098.601ENSHGLG00000009991RBM410098.601Heterocephalus_glaber_female
ENSG00000173933RBM410098.780ENSHGLG00000016412-9698.780Heterocephalus_glaber_female
ENSG00000173933RBM410098.780ENSHGLG00100003978-9698.780Heterocephalus_glaber_male
ENSG00000173933RBM410098.601ENSHGLG00100003854RBM410098.601Heterocephalus_glaber_male
ENSG00000173933RBM49788.406ENSHGLG00100020033-10085.976Heterocephalus_glaber_male
ENSG00000173933RBM49798.551ENSSTOG00000011226RBM4B9698.780Ictidomys_tridecemlineatus
ENSG00000173933RBM4100100.000ENSSTOG00000022811RBM4100100.000Ictidomys_tridecemlineatus
ENSG00000173933RBM49375.188ENSJJAG00000003168-9872.340Jaculus_jaculus
ENSG00000173933RBM410094.512ENSJJAG00000020870Rbm4b9694.512Jaculus_jaculus
ENSG00000173933RBM49798.551ENSLAFG00000002285RBM4B9698.780Loxodonta_africana
ENSG00000173933RBM49798.551ENSLAFG00000028147-10094.795Loxodonta_africana
ENSG00000173933RBM410096.503ENSMFAG00000033927RBM4B9798.551Macaca_fascicularis
ENSG00000173933RBM49798.551ENSMNEG00000043371RBM4B9897.857Macaca_nemestrina
ENSG00000173933RBM410096.503ENSMLEG00000028563RBM4B9897.857Mandrillus_leucophaeus
ENSG00000173933RBM49798.551ENSMAUG00000017027Rbm4b9698.780Mesocricetus_auratus
ENSG00000173933RBM410097.902ENSMICG00000047975-9997.902Microcebus_murinus
ENSG00000173933RBM410095.804ENSMICG00000003817-10095.804Microcebus_murinus
ENSG00000173933RBM410098.780ENSMICG00000003820RBM4B9897.857Microcebus_murinus
ENSG00000173933RBM49798.551ENSMOCG00000001835Rbm4b9698.780Microtus_ochrogaster
ENSG00000173933RBM410096.951ENSMODG00000008056-10090.489Monodelphis_domestica
ENSG00000173933RBM410098.601MGP_CAROLIEiJ_G0022516-10098.601Mus_caroli
ENSG00000173933RBM49798.551MGP_CAROLIEiJ_G0022515Rbm4b9698.780Mus_caroli
ENSG00000173933RBM49987.013MGP_CAROLIEiJ_G0022514-10071.038Mus_caroli
ENSG00000173933RBM410095.890ENSMUSG00000096370Gm2199210095.890Mus_musculus
ENSG00000173933RBM410095.804ENSMUSG00000033760Rbm4b9698.780Mus_musculus
ENSG00000173933RBM410098.601ENSMUSG00000094936Rbm410098.837Mus_musculus
ENSG00000173933RBM49798.551MGP_PahariEiJ_G0014012Rbm4b9698.780Mus_pahari
ENSG00000173933RBM410096.164MGP_PahariEiJ_G0014011-10096.164Mus_pahari
ENSG00000173933RBM410098.601MGP_PahariEiJ_G0014013-10098.601Mus_pahari
ENSG00000173933RBM410073.868MGP_SPRETEiJ_G0023429-10075.694Mus_spretus
ENSG00000173933RBM410087.013MGP_SPRETEiJ_G0023428-9479.511Mus_spretus
ENSG00000173933RBM410087.013MGP_SPRETEiJ_G0023430-10079.511Mus_spretus
ENSG00000173933RBM49798.551ENSMPUG00000003450RBM4B9698.780Mustela_putorius_furo
ENSG00000173933RBM4100100.000ENSMPUG00000003443RBM410098.904Mustela_putorius_furo
ENSG00000173933RBM410099.390ENSMLUG00000004076RBM49596.961Myotis_lucifugus
ENSG00000173933RBM410098.780ENSMLUG00000001290RBM4B9698.780Myotis_lucifugus
ENSG00000173933RBM49798.551ENSNGAG00000016292Rbm4b9698.780Nannospalax_galili
ENSG00000173933RBM4100100.000ENSNLEG00000035021RBM4100100.000Nomascus_leucogenys
ENSG00000173933RBM410095.804ENSNLEG00000006213RBM4B9897.857Nomascus_leucogenys
ENSG00000173933RBM410098.171ENSMEUG00000001445-9698.171Notamacropus_eugenii
ENSG00000173933RBM46286.344ENSMEUG00000005739-10086.404Notamacropus_eugenii
ENSG00000173933RBM410098.780ENSOPRG00000009158RBM4B9698.780Ochotona_princeps
ENSG00000173933RBM410098.356ENSOPRG00000009149RBM410098.356Ochotona_princeps
ENSG00000173933RBM410095.804ENSODEG00000019143-10095.804Octodon_degus
ENSG00000173933RBM49799.275ENSODEG00000017696-9699.390Octodon_degus
ENSG00000173933RBM410085.366ENSODEG00000001866-9685.366Octodon_degus
ENSG00000173933RBM410097.203ENSODEG00000020039-10097.203Octodon_degus
ENSG00000173933RBM410076.923ENSODEG00000006635-10076.923Octodon_degus
ENSG00000173933RBM410098.780ENSOANG00000003143-8198.780Ornithorhynchus_anatinus
ENSG00000173933RBM410098.780ENSOANG00000011036-9698.780Ornithorhynchus_anatinus
ENSG00000173933RBM410099.452ENSOCUG00000004731RBM410099.452Oryctolagus_cuniculus
ENSG00000173933RBM49798.551ENSOCUG00000006695LARK9698.780Oryctolagus_cuniculus
ENSG00000173933RBM49798.551ENSOGAG00000015648RBM4B9698.780Otolemur_garnettii
ENSG00000173933RBM410099.452ENSOGAG00000015647RBM410099.452Otolemur_garnettii
ENSG00000173933RBM49798.551ENSOARG00000007759RBM4B9698.780Ovis_aries
ENSG00000173933RBM497100.000ENSOARG00000007700RBM496100.000Ovis_aries
ENSG00000173933RBM410095.804ENSPPAG00000015125RBM4B9897.857Pan_paniscus
ENSG00000173933RBM49798.551ENSPPRG00000003388RBM4B9897.857Panthera_pardus
ENSG00000173933RBM4100100.000ENSPPRG00000003533RBM4100100.000Panthera_pardus
ENSG00000173933RBM49798.551ENSPTIG00000015426RBM4B9897.857Panthera_tigris_altaica
ENSG00000173933RBM410099.301ENSPTIG00000016180RBM410099.301Panthera_tigris_altaica
ENSG00000173933RBM410095.804ENSPTRG00000003935RBM4B9897.857Pan_troglodytes
ENSG00000173933RBM49798.551ENSPANG00000020672RBM4B9897.857Papio_anubis
ENSG00000173933RBM49795.652ENSPSIG00000003477-9577.740Pelodiscus_sinensis
ENSG00000173933RBM410095.732ENSPSIG00000003430-9695.732Pelodiscus_sinensis
ENSG00000173933RBM49798.551ENSPEMG00000009144Rbm4b9698.780Peromyscus_maniculatus_bairdii
ENSG00000173933RBM49798.551ENSPPYG00000003010RBM4B9698.780Pongo_abelii
ENSG00000173933RBM4100100.000ENSPPYG00000003012RBM410098.901Pongo_abelii
ENSG00000173933RBM410096.438ENSPCAG00000003393-10096.438Procavia_capensis
ENSG00000173933RBM49798.551ENSPCOG00000027885RBM4B9998.561Propithecus_coquereli
ENSG00000173933RBM49798.551ENSPVAG00000010487RBM4B9698.780Pteropus_vampyrus
ENSG00000173933RBM4100100.000ENSPVAG00000010486RBM410098.356Pteropus_vampyrus
ENSG00000173933RBM49798.551ENSRNOG00000061795Rbm4b9698.780Rattus_norvegicus
ENSG00000173933RBM410098.601ENSRNOG00000050741Rbm410098.601Rattus_norvegicus
ENSG00000173933RBM49798.551ENSRBIG00000019394RBM4B9897.857Rhinopithecus_bieti
ENSG00000173933RBM497100.000ENSRROG00000032796-90100.000Rhinopithecus_roxellana
ENSG00000173933RBM49798.551ENSRROG00000032850RBM4B9897.857Rhinopithecus_roxellana
ENSG00000173933RBM49797.826ENSSBOG00000034474RBM4B9897.143Saimiri_boliviensis_boliviensis
ENSG00000173933RBM410098.780ENSSHAG00000008386-10087.945Sarcophilus_harrisii
ENSG00000173933RBM49798.551ENSSARG00000010710RBM4B9698.780Sorex_araneus
ENSG00000173933RBM4100100.000ENSSSCG00000032437RBM410099.178Sus_scrofa
ENSG00000173933RBM49796.377ENSTGUG00000016779-9477.740Taeniopygia_guttata
ENSG00000173933RBM496100.000ENSTBEG00000003727-70100.000Tupaia_belangeri
ENSG00000173933RBM410098.780ENSTBEG00000003748RBM4B9698.780Tupaia_belangeri
ENSG00000173933RBM410097.260ENSTTRG00000011164RBM410097.260Tursiops_truncatus
ENSG00000173933RBM410098.171ENSTTRG00000011166RBM4B9698.171Tursiops_truncatus
ENSG00000173933RBM4100100.000ENSUAMG00000014882RBM4100100.000Ursus_americanus
ENSG00000173933RBM410098.780ENSUAMG00000004745RBM4B9698.780Ursus_americanus
ENSG00000173933RBM410099.301ENSUMAG00000011738-10099.301Ursus_maritimus
ENSG00000173933RBM4100100.000ENSVPAG00000001949RBM410096.712Vicugna_pacos
ENSG00000173933RBM49797.826ENSVPAG00000001950RBM4B9698.171Vicugna_pacos
ENSG00000173933RBM49989.362ENSVVUG00000011717-10085.714Vulpes_vulpes
ENSG00000173933RBM410098.780ENSVVUG00000010619RBM4B9698.780Vulpes_vulpes
ENSG00000173933RBM410098.780ENSVVUG00000010622RBM410098.630Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000381regulation of alternative mRNA splicing, via spliceosome21873635.IBAProcess
GO:0000381regulation of alternative mRNA splicing, via spliceosome12628928.16260624.16777844.16934801.21518792.IDAProcess
GO:0002190cap-independent translational initiation17284590.IDAProcess
GO:0002192IRES-dependent translational initiation of linear mRNA17284590.IDAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding21873635.IBAFunction
GO:0003723RNA binding19561594.IDAFunction
GO:0003729mRNA binding21518792.IDAFunction
GO:0003730mRNA 3'-UTR binding-ISSFunction
GO:0005515protein binding12628928.16934801.17284590.19801630.21343338.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16777844.16907643.17284590.IDAComponent
GO:0005654nucleoplasm12628928.IDAComponent
GO:0005730nucleolus12628928.16907643.IDAComponent
GO:0005737cytoplasm12628928.16777844.16907643.17284590.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0006396RNA processing9169144.TASProcess
GO:0008270zinc ion binding-IEAFunction
GO:0010494cytoplasmic stress granule17284590.IDAComponent
GO:0016607nuclear speck21873635.IBAComponent
GO:0016607nuclear speck12628928.16907643.IDAComponent
GO:0017148negative regulation of translation17284590.IDAProcess
GO:0030154cell differentiation-IEAProcess
GO:0030332cyclin binding15159402.IPIFunction
GO:0032055negative regulation of translation in response to stress17284590.IDAProcess
GO:0035198miRNA binding19801630.IDAFunction
GO:0035278miRNA mediated inhibition of translation19801630.IDAProcess
GO:0043153entrainment of circadian clock by photoperiod-ISSProcess
GO:0045292mRNA cis splicing, via spliceosome21873635.IBAProcess
GO:0045947negative regulation of translational initiation19801630.IDAProcess
GO:0046685response to arsenic-containing substance17284590.IDAProcess
GO:0046822regulation of nucleocytoplasmic transport12628928.17284590.IDAProcess
GO:0051149positive regulation of muscle cell differentiation21518792.IDAProcess
GO:0097157pre-mRNA intronic binding16260624.IDAFunction
GO:0097158pre-mRNA intronic pyrimidine-rich binding16260624.16777844.IDAFunction
GO:0097167circadian regulation of translation-ISSProcess
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