EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr11	65795102	Silent	novel	L189L	0.17
BLCA	chr11	65794044	Silent	novel	F38F	0.38
BLCA	chr11	65794242	Silent	novel	K104K	0.15
BRCA	chr11	65794720	Silent	NA	T167T	0.12
BRCA	chr11	65796039	3'UTR	novel		0.07
BRCA	chr11	65793944	Intron	novel		0.24
BRCA	chr11	65795278	Silent	NA	K247K	0.48
CESC	chr11	65796031	3'UTR	novel		0.34
CESC	chr11	65795162	Missense_Mutation	novel	R209W	0.28
CESC	chr11	65795149	Silent	rs201146309	A204A	0.33
CESC	chr11	65796178	3'UTR	novel		0.13
CESC	chr11	65794186	Missense_Mutation	novel	D86H	0.13
COAD	chr11	65794610	Missense_Mutation	rs199678307	R131C	0.38
COAD	chr11	65794049	Missense_Mutation	NA	P40L	0.35
COAD	chr11	65795130	Missense_Mutation	rs774919756	G198D	0.06
COAD	chr11	65787264	5'UTR	novel		0.31
COAD	chr11	65795264	Missense_Mutation	novel	R243C	0.19
GBM	chr11	65794234	Missense_Mutation	rs547964049	R102C	0.35
GBM	chr11	65795094	Missense_Mutation	NA	R186H	0.39	zf-C2H2
HNSC	chr11	65795162	Missense_Mutation	novel	R209W	0.47
HNSC	chr11	65794623	Missense_Mutation	novel	R135H	0.2
KIRC	chr11	65795101	Silent	novel	S188S	0.36
KIRP	chr11	65795340	Nonstop_Mutation	NA	268Lext59	0.09
KIRP	chr11	65795341	Nonstop_Mutation	NA	268Cext59	0.1
LAML	chr11	65794194	Silent	novel	G88G	0.13
LGG	chr11	65787411	Missense_Mutation	novel	S13F	0.5
LIHC	chr11	65794623	Missense_Mutation	novel	R135H	0.27
LUAD	chr11	65787440	Missense_Mutation	novel	P23T	0.28
LUAD	chr11	65794113	Missense_Mutation	rs781707967	L61F	0.27
LUAD	chr11	65794078	Missense_Mutation	novel	S50T	0.09
LUAD	chr11	65795297	Missense_Mutation	NA	Q254E	0.42
LUAD	chr11	65794188	Missense_Mutation	novel	D86E	0.44
LUAD	chr11	65795389	3'UTR	novel		0.56
LUSC	chr11	65795192	Missense_Mutation	rs779727157	G219S	0.25
OV	chr11	65787435	Missense_Mutation	NA	E21V	0.4
PAAD	chr11	65795052	Missense_Mutation	novel	R172Q	0.21
PRAD	chr11	65794642	Silent	rs778793840	N141N	0.33
SARC	chr11	65794631	Nonsense_Mutation	novel	K138*	0.2
SARC	chr11	65793929	Intron	novel		0.23
SKCM	chr11	65794245	Missense_Mutation	NA	M105I	0.49
SKCM	chr11	65794226	Missense_Mutation	NA	G99D	0.48
SKCM	chr11	65795126	Missense_Mutation	NA	H197Y	0.19
SKCM	chr11	65794026	Splice_Region	rs754483024		0.19
SKCM	chr11	65794666	Silent	novel	T149T	0.54
SKCM	chr11	65794126	Nonsense_Mutation	NA	R66*	0.13
SKCM	chr11	65794696	Silent	rs765882500	F159F	0.15
SKCM	chr11	65795129	Missense_Mutation	NA	G198S	0.12
STAD	chr11	65795088	Missense_Mutation	rs151272806	T184M	0.1	zf-C2H2
STAD	chr11	65795319	Missense_Mutation	novel	L261Q	0.13
STAD	chr11	65794646	Missense_Mutation	rs577150616	V143I	0.24
UCEC	chr11	65794716	Missense_Mutation	NA	R166Q	0.31
UCEC	chr11	65795264	Missense_Mutation	novel	R243C	0.11
UCEC	chr11	65795149	Silent	rs201146309	A204A	0.24
UCEC	chr11	65795393	3'UTR	novel		0.3
UCEC	chr11	65794153	Missense_Mutation	novel	G75R	0.35
UCEC	chr11	65794646	Missense_Mutation	rs577150616	V143I	0.33
UCEC	chr11	65794071	Silent	rs142142282	P47P	0.05
UCEC	chr11	65796039	3'UTR	novel		0.1
UCEC	chr11	65787327	5'UTR	rs781134378		0.49
UCEC	chr11	65793930	Intron	novel		0.67
UCEC	chr11	65795933	3'UTR	novel		0.31
UCEC	chr11	65796132	3'UTR	novel		0.4
UCEC	chr11	65794711	Silent	rs377708693	H164H	0.41
UCEC	chr11	65795145	Missense_Mutation	novel	Y203C	0.29
UCEC	chr11	65794206	Frame_Shift_Del	novel	*Q94Rfs12**	0.19
UCEC	chr11	65796313	3'UTR	novel		0.38
UCEC	chr11	65794716	Missense_Mutation	NA	R166Q	0.35
UCEC	chr11	65795965	3'UTR	novel		0.5
UCEC	chr11	65796086	3'UTR	novel		0.26
UCEC	chr11	65795820	3'UTR	novel		0.44
UCEC	chr11	65794657	Silent	novel	H146H	0.17

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.1694	1.2183e-05
ESCA	AMP	0.212	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.027	Kaplan-Meier Survival Analysis
SKCM	0.0004	Kaplan-Meier Survival Analysis
BRCA	0.0097	Kaplan-Meier Survival Analysis
ESCA	0.022	Kaplan-Meier Survival Analysis
KIRP	0.00016	Kaplan-Meier Survival Analysis
PAAD	0.0013	Kaplan-Meier Survival Analysis
UCEC	0.00068	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000172818 (Gene tree)
Gene ID: 5017
Gene Symbol: OVOL1
Alias: HOVO1
Full Name: ovo like transcriptional repressor 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 10,198 bases
Position: chr11:65,787,022-65,797,219
Accession: 8525
Summary: This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000434220	zf-C2H2	PF00096.26	1.2e-13	1	3
ENSP00000434220	zf-C2H2	PF00096.26	1.2e-13	2	3
ENSP00000434220	zf-C2H2	PF00096.26	1.2e-13	3	3
ENSP00000337862	zf-C2H2	PF00096.26	3.7e-13	1	3
ENSP00000337862	zf-C2H2	PF00096.26	3.7e-13	2	3
ENSP00000337862	zf-C2H2	PF00096.26	3.7e-13	3	3
ENSP00000434220	zf-met	PF12874.7	0.0005	1	2
ENSP00000434220	zf-met	PF12874.7	0.0005	2	2
ENSP00000337862	zf-met	PF12874.7	0.0015	1	2
ENSP00000337862	zf-met	PF12874.7	0.0015	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000532448	OVOL1-203	1774	XM_005274018	ENSP00000434220	205 (aa)	XP_005274075	G3V1B0
ENST00000531907	OVOL1-202	558	-	-	- (aa)	-	-
ENST00000335987	OVOL1-201	3034	-	ENSP00000337862	267 (aa)	-	O14753

Gene Model

Click here to download ENSG00000172818's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000172818	Dermatitis, Atopic	2E-19	26482879
ENSG00000172818	Uric Acid	3E-13	23263486

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172818	rs10896045	11	65788053	G	Blood protein levels	29875488	[0.12-0.24] unit decrease	0.18	EFO_0007937
ENSG00000172818	rs642803	11	65793149	T	Urate levels	23263486	[0.026-0.045] mg/dl decrease	0.036	EFO_0004531
ENSG00000172818	rs642803	11	65793149	T	Educational attainment (MTAG)	30038396	[0.0049-0.0099] unit increase	0.0074	EFO_0004784
ENSG00000172818	rs642803	11	65793149	T	Highest math class taken (MTAG)	30038396	[0.0058-0.0124] unit increase	0.0091	EFO_0004875
ENSG00000172818	rs56019505	11	65794334	G	Blond vs. brown/black hair color	30531825	NR	1.087	EFO_0003924
ENSG00000172818	rs12797706	11	65793898	?	Hair color	30595370			EFO_0007822
ENSG00000172818	rs10791824	11	65791795	?	Eczema	30595370			HP_0000964
ENSG00000172818	rs11227302	11	65787031	A	Systemic lupus erythematosus	28714469	[1.08-1.21]	1.15	EFO_0002690
ENSG00000172818	rs644740	11	65793997	T	Age of smoking initiation (MTAG)	30643251	[0.0059-0.0117] unit increase	0.00881013	EFO_0005670
ENSG00000172818	rs644740	11	65793997	T	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0051-0.0093] unit decrease	0.00719881	EFO_0006527
ENSG00000172818	rs644740	11	65793997	T	Smoking initiation (ever regular vs never regular)	30643251	[0.0091-0.0191] unit decrease	0.014078517	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172818's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172818	OVOL1	100	94.634	ENSCLAG00000016426	OVOL1	79	94.068	Chinchilla_lanigera
ENSG00000172818	OVOL1	100	71.220	ENSCPBG00000023411	OVOL1	100	71.161	Chrysemys_picta_bellii
ENSG00000172818	OVOL1	100	90.732	ENSDNOG00000024062	OVOL1	98	89.496	Dasypus_novemcinctus
ENSG00000172818	OVOL1	100	95.131	ENSDORG00000028510	Ovol1	100	95.131	Dipodomys_ordii
ENSG00000172818	OVOL1	77	97.452	ENSEEUG00000010161	OVOL1	99	96.835	Erinaceus_europaeus
ENSG00000172818	OVOL1	80	68.902	ENSGALG00000049996	OVOL1	73	67.429	Gallus_gallus
ENSG00000172818	OVOL1	100	72.195	ENSGAGG00000008199	OVOL1	100	71.536	Gopherus_agassizii
ENSG00000172818	OVOL1	100	94.757	ENSJJAG00000024400	Ovol1	100	94.757	Jaculus_jaculus
ENSG00000172818	OVOL1	100	95.506	MGP_CAROLIEiJ_G0022558	Ovol1	100	95.506	Mus_caroli
ENSG00000172818	OVOL1	100	95.506	ENSMUSG00000024922	Ovol1	100	95.506	Mus_musculus
ENSG00000172818	OVOL1	100	94.757	MGP_PahariEiJ_G0014055	Ovol1	100	94.757	Mus_pahari
ENSG00000172818	OVOL1	100	95.880	MGP_SPRETEiJ_G0023472	Ovol1	100	95.880	Mus_spretus
ENSG00000172818	OVOL1	100	96.255	ENSOGAG00000016496	OVOL1	100	96.255	Otolemur_garnettii
ENSG00000172818	OVOL1	95	70.769	ENSPSIG00000002913	OVOL1	100	64.748	Pelodiscus_sinensis
ENSG00000172818	OVOL1	100	94.382	ENSRNOG00000020669	Ovol1	100	94.382	Rattus_norvegicus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0001822	kidney development	-	IEA	Process
GO:0005634	nucleus	21873635.	IBA	Component
GO:0007283	spermatogenesis	-	IEA	Process
GO:0007498	mesoderm development	-	IEA	Process
GO:0009913	epidermal cell differentiation	21873635.	IBA	Process
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0043588	skin development	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	-	IEA	Process
GO:1901994	negative regulation of meiotic cell cycle phase transition	-	IEA	Process
GO:2000647	negative regulation of stem cell proliferation	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.