EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29335436Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.Nat Commun2018 Jan 15Chen Mdoi: 10.1038/s41467-017-02272-y.
24574500Identification of two forms of TNF tolerance in human monocytes: differential inhibition of NF-??B/AP-1- and PP1-associated signaling.J Immunol2014 Apr 1G??nther Jdoi: 10.4049/jimmunol.1301610
26033480Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells.Apoptosis2015 SepKim Wdoi: 10.1007/s10495-015-1141-1.
21106093Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.BMC Cancer2010 Nov 24Brems-Eskildsen ASdoi: 10.1186/1471-2407-10-646.
23176181PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.Curr Mol Med2013 JanChen PC-
26636645Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation.Oncotarget2016 Jan 12Liu Xdoi: 10.18632/oncotarget.6434.
29187447Analysis of Autoantibodies Related to Tumor Progression in Sera from Patients with High-grade Non-muscle-invasive Bladder Cancer.Anticancer Res2017 DecMinami S-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1167399107Missense_MutationNAD194N0.23
BLCAchr1167401188Missense_MutationnovelR23W0.22
BLCAchr1167398950Missense_Mutationrs772793107R246Q0.13
BLCAchr1167400738SilentnovelG123G0.15
BLCAchr1167399616Missense_MutationnovelF156L0.2
BLCAchr1167401139Missense_MutationnovelC39Y0.14
BLCAchr1167400729Missense_MutationNAE126D0.15
BRCAchr1167401116SilentNAL47L0.31
BRCAchr1167399108SilentNAT193T0.5
CESCchr1167399585Missense_MutationnovelE167K0.11
CESCchr1167400717SilentNAI130I0.38
CESCchr11673984473'UTRnovel0.2
CESCchr1167400753Silentrs748972777F118F0.2
CHOLchr1167400817Missense_MutationNAG97D0.12
COADchr1167400699Missense_MutationnovelF136L0.4
COADchr1167398789Missense_MutationNAY272C0.3
COADchr11673985283'UTRrs178802510.36
COADchr1167398725SilentNAF293F0.37
COADchr1167399656Missense_MutationNAR143H0.18
COADchr1167401264Intronnovel0.41
COADchr1167398613SilentNAK305K0.18
COADchr1167398646Splice_SitenovelX295_splice0.13
DLBCchr1167400853Missense_MutationnovelS85T0.21
DLBCchr1167401448Intronnovel0.57
ESCAchr1167400692Nonsense_MutationnovelE139*0.16
GBMchr1167401206Splice_Regionnovel0.4
GBMchr11673984643'UTRnovel0.33
HNSCchr11673985223'UTRnovel0.25
HNSCchr1167399575Missense_Mutationrs760799660F170C0.12
KIRPchr1167401117SilentnovelF46F0.27
LIHCchr1167398812SilentnovelV264V0.42
LIHCchr1167398754Missense_MutationNAS284G0.07
LIHCchr1167398617Frame_Shift_DelnovelK301Rfs*90.16
LUADchr1167399152Frame_Shift_DelnovelD179Tfs*730.16
LUADchr1167401106Missense_MutationNAP50H0.29
LUSCchr1167398605Missense_MutationnovelQ308L0.23
LUSCchr1167401235Intronnovel0.1
LUSCchr1167401146Missense_MutationNAG37C0.44
LUSCchr1167401080Missense_MutationnovelL59I0.13
LUSCchr1167400798SilentnovelT103T0.09
LUSCchr1167399040Nonsense_MutationnovelW216*0.39
LUSCchr1167401237Intronnovel0.31
MESOchr1167401568Intronnovel0.4
MESOchr1167400816In_Frame_DelnovelE77_G97del0.12
OVchr1167400751Missense_MutationnovelF119C0.05
OVchr1167399004In_Frame_InsnovelG228delinsAQDFRKEQVMR0.23
PAADchr1167398633Missense_Mutationrs773623660A299T0.18
PRADchr1167399644Missense_MutationNAK147I0.15
SARCchr1167401017Intronnovel0.83
SKCMchr1167399585Nonsense_MutationNAE167*0.37
SKCMchr1167399029Missense_MutationNAD220N0.21
SKCMchr1167399035Missense_MutationNAE218K0.43
SKCMchr1167398545Missense_MutationnovelA328V0.29
STADchr1167399114SilentnovelR191R0.22
STADchr11673984373'UTRnovel0.71
STADchr1167401200Splice_SiteNAX19_splice0.25
STADchr1167400697Missense_MutationNAY137C0.15
UCECchr1167401194Missense_MutationNAG21C0.24
UCECchr1167399644Missense_MutationnovelK147T0.37
UCECchr1167398560Missense_Mutationrs766862399R323H0.41
UCECchr1167398630Missense_Mutationrs774510465D300N0.09
UCECchr1167400810SilentnovelQ99Q0.42
UCECchr1167398552Missense_Mutationrs140048086A326T0.26
UCECchr11673984143'UTRnovel0.51
UCECchr1167400753Missense_MutationnovelF118L0.38
UCECchr1167398776SilentnovelF276F0.27
UCECchr1167400817Missense_MutationNAG97D0.25
UCECchr1167401200Splice_SiteNAX19_splice0.23
UCECchr1167399585Missense_MutationnovelE167K0.47
UCECchr1167399050Missense_MutationnovelV213M0.41
UCECchr1167401324Intronnovel0.3
UCECchr1167400759Missense_MutationNAE116D0.4
UCECchr1167400761Missense_MutationnovelE116K0.53

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.27720.018342
PRADAMP0.07111.1386e-05
TGCTDEL0.71330.21504

Survival Analysis
CancerP-value Q-value
THYM0.013

Kaplan-Meier Survival Analysis

MESO0.019

Kaplan-Meier Survival Analysis

ACC0.00015

Kaplan-Meier Survival Analysis

PAAD0.013

Kaplan-Meier Survival Analysis

PCPG0.041

Kaplan-Meier Survival Analysis

CESC0.014

Kaplan-Meier Survival Analysis

LAML0.00031

Kaplan-Meier Survival Analysis

LIHC0.0015

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.0044

Kaplan-Meier Survival Analysis

UVM0.0097

Kaplan-Meier Survival Analysis

OV0.042

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000172531 (Gene tree)
Gene ID
5499
Gene Symbol
PPP1CA
Alias
PP1A|PP-1A|PP1alpha|PPP1A
Full Name
protein phosphatase 1 catalytic subunit alpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
23,003 bases
Position
chr11:67,398,181-67,421,183
Accession
9281
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000529724PPP1CA-206572--- (aa)--
ENST00000358239PPP1CA-2021054-ENSP00000350974286 (aa)-P62136
ENST00000526510PPP1CA-2041677--- (aa)--
ENST00000312989PPP1CA-2011389-ENSP00000326031341 (aa)-P62136
ENST00000537694PPP1CA-209882--- (aa)--
ENST00000546202PPP1CA-211554-ENSP00000439568169 (aa)-F5H1L6
ENST00000527663PPP1CA-205765-ENSP00000431146253 (aa)-E9PMD7
ENST00000532279PPP1CA-207552--- (aa)--
ENST00000542876PPP1CA-210588-ENSP00000438409179 (aa)-F5H037
ENST00000376745PPP1CA-2031476-ENSP00000365936330 (aa)-P62136
ENST00000532446PPP1CA-2081465--- (aa)--
Gene Model
Click here to download ENSG00000172531's gene model file
Pathways
Pathway IDPathway NameSource
hsa03015mRNA surveillance pathwayKEGG
hsa04022cGMP-PKG signaling pathwayKEGG
hsa04024cAMP signaling pathwayKEGG
hsa04114Oocyte meiosisKEGG
hsa04218Cellular senescenceKEGG
hsa04261Adrenergic signaling in cardiomyocytesKEGG
hsa04270Vascular smooth muscle contractionKEGG
hsa04390Hippo signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04611Platelet activationKEGG
hsa04720Long-term potentiationKEGG
hsa04728Dopaminergic synapseKEGG
hsa04750Inflammatory mediator regulation of TRP channelsKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04910Insulin signaling pathwayKEGG
hsa04921Oxytocin signaling pathwayKEGG
hsa04931Insulin resistanceKEGG
hsa05031Amphetamine addictionKEGG
hsa05034AlcoholismKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
hsa05205Proteoglycans in cancerKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000172531rs617346011167417254AHeight28270201[0.0054-0.0102] m decrease0.007811173EFO_0004339
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172531's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000172531PPP1CA9093.603FBgn0004103Pp1-87B9893.603Drosophila_melanogaster
ENSG00000172531PPP1CA10090.663ENSG00000186298PPP1CC10094.286Homo_sapiens
ENSG00000172531PPP1CA10099.697ENSMUSG00000040385Ppp1ca10099.697Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000164protein phosphatase type 1 complex-IEAComponent
GO:0000784nuclear chromosome, telomeric region24270157.IDAComponent
GO:0004721phosphoprotein phosphatase activity-ISSFunction
GO:0004722protein serine/threonine phosphatase activity21873635.IBAFunction
GO:0004722protein serine/threonine phosphatase activity10640627.16262633.TASFunction
GO:0005515protein binding10807923.11739654.12434308.15231748.16263087.16732323.17274640.17318175.17511879.17965019.18068675.18842582.19389623.20186153.20305656.20424263.20467437.20516061.20826336.20926688.21094159.21382349.21518769.21666598.21998301.22321011.22365833.22940584.23396208.23555304.23937259.24366813.25416956.25544563.25593058.25785436.27173435.28330616.29109149.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11739654.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm11739654.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0005913cell-cell adherens junction25468996.IDAComponent
GO:0005977glycogen metabolic process-IEAProcess
GO:0005979regulation of glycogen biosynthetic process-IEAProcess
GO:0005981regulation of glycogen catabolic process-IEAProcess
GO:0006470protein dephosphorylation22311981.22801782.IMPProcess
GO:0006470protein dephosphorylation-ISSProcess
GO:0007049cell cycle-IEAProcess
GO:0008157protein phosphatase 1 binding21873635.IBAFunction
GO:0010288response to lead ion-ISSProcess
GO:0016311dephosphorylation22311981.IDAProcess
GO:0016791phosphatase activity-ISSFunction
GO:0030324lung development-IEAProcess
GO:0032091negative regulation of protein binding-ISSProcess
GO:0032922circadian regulation of gene expression-ISSProcess
GO:0035970peptidyl-threonine dephosphorylation16262633.TASProcess
GO:0036496regulation of translational initiation by eIF2 alpha dephosphorylation-ISSProcess
GO:0042587glycogen granule-IEAComponent
GO:0042752regulation of circadian rhythm21873635.IBAProcess
GO:0042752regulation of circadian rhythm21712997.IMPProcess
GO:0043021ribonucleoprotein complex binding-IEAFunction
GO:0043153entrainment of circadian clock by photoperiod21873635.IBAProcess
GO:0043153entrainment of circadian clock by photoperiod-ISSProcess
GO:0043197dendritic spine-IEAComponent
GO:0043204perikaryon-IEAComponent
GO:0046872metal ion binding-IEAFunction
GO:0048754branching morphogenesis of an epithelial tube-IEAProcess
GO:0051301cell division-IEAProcess
GO:0060828regulation of canonical Wnt signaling pathway17318175.ICProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0070262peptidyl-serine dephosphorylation16262633.TASProcess
GO:0072357PTW/PP1 phosphatase complex20516061.IDAComponent
GO:0098609cell-cell adhesion-IEAProcess
GO:0098641cadherin binding involved in cell-cell adhesion25468996.IDAFunction
GO:0098793presynapse-IEAComponent
GO:0098978glutamatergic synapse-IEAComponent
GO:1904886beta-catenin destruction complex disassembly-ISSProcess
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEAProcess
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