EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29195126	Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer.	Neoplasia	2018 Jan	Lin SL	doi: 10.1016/j.neo.2017.10.007

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr15	88652210	Missense_Mutation	novel	T110R	0.25
BLCA	chr15	88639502	Missense_Mutation	rs770868397	E46Q	0.13	RNase_T
BLCA	chr15	88639456	Silent	rs144037981	L30L	0.42
BRCA	chr15	88655544	3'UTR	rs773706877		0.29
BRCA	chr15	88655544	3'UTR	rs773706877		0.33
BRCA	chr15	88651925	Intron	novel		0.13
BRCA	chr15	88655555	3'UTR	novel		0.15
COAD	chr15	88651966	Intron	novel		0.35
COAD	chr15	88655630	3'UTR	novel		0.67
COAD	chr15	88655424	Missense_Mutation	novel	L147F	0.5
COAD	chr15	88639548	Missense_Mutation	rs371941091	P61H	0.28	RNase_T
ESCA	chr15	88652080	Intron	novel		0.28
ESCA	chr15	88652202	Missense_Mutation	novel	I107M	0.16
ESCA	chr15	88639508	Missense_Mutation	novel	E48Q	0.19	RNase_T
GBM	chr15	88639445	Missense_Mutation	rs752810937	R27C	0.56	RNase_T
GBM	chr15	88655609	3'UTR	novel		0.4
HNSC	chr15	88652260	Missense_Mutation	rs781386863	R127C	0.12
LIHC	chr15	88639378	Silent	NA	S4S	0.73
LUAD	chr15	88655438	Silent	NA	S151S	0.49
LUAD	chr15	88652280	Silent	novel	L133L	0.21
LUAD	chr15	88655512	Missense_Mutation	rs748762729	R176H	0.22
LUSC	chr15	88655649	3'UTR	novel		0.27
LUSC	chr15	88639504	Missense_Mutation	NA	E46D	0.11	RNase_T
LUSC	chr15	88655455	Missense_Mutation	rs769145683	A157V	0.15
OV	chr15	88655566	3'UTR	novel		0.5
READ	chr15	88652234	Missense_Mutation	rs549880749	R118H	0.2
SKCM	chr15	88655556	3'UTR	novel		0.38
SKCM	chr15	88655570	3'UTR	rs752817650		0.39
SKCM	chr15	88652077	Intron	novel		0.37
SKCM	chr15	88639492	Silent	NA	F42F	0.16
SKCM	chr15	88652049	Intron	novel		0.36
SKCM	chr15	88652240	Missense_Mutation	NA	A120V	0.18
STAD	chr15	88652225	Missense_Mutation	NA	L115R	0.31
STAD	chr15	88652273	Missense_Mutation	rs771930617	R131Q	0.36
STAD	chr15	88652272	Missense_Mutation	rs747830918	R131W	0.16
UCEC	chr15	88639575	Missense_Mutation	NA	F70C	0.27	RNase_T
UCEC	chr15	88655499	Nonsense_Mutation	rs369479597	R172*	0.32
UCEC	chr15	88655449	Missense_Mutation	novel	A155V	0.44
UCEC	chr15	88652210	Missense_Mutation	rs772920253	T110M	0.46
UCEC	chr15	88655646	3'UTR	novel		0.44
UCEC	chr15	88639456	Silent	rs144037981	L30L	0.56
UCEC	chr15	88655507	Silent	novel	L174L	0.1
UCEC	chr15	88651809	Intron	novel		0.39
UCEC	chr15	88652116	Nonsense_Mutation	rs531794921	Q79*	0.49
UCEC	chr15	88652206	Missense_Mutation	NA	D109N	0.29
UCEC	chr15	88652287	Missense_Mutation	rs760289978	R136C	0.4
UCEC	chr15	88651796	Intron	novel		0.3
UCEC	chr15	88652261	Missense_Mutation	rs149381576	R127H	0.41
UCS	chr15	88655479	Missense_Mutation	NA	S165F	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2169	0.0058042
LGG	AMP	0.0214	0.19963
LIHC	DEL	0.1703	0.056724
PAAD	AMP	0.0761	0.20695
PAAD	DEL	0.1033	0.13216
SKCM	AMP	0.2452	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
MESO	0.018	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.019	Kaplan-Meier Survival Analysis
SKCM	0.00094	Kaplan-Meier Survival Analysis
BRCA	0.011	Kaplan-Meier Survival Analysis
KIRP	0.0099	Kaplan-Meier Survival Analysis
COAD	0.041	Kaplan-Meier Survival Analysis
PAAD	0.043	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
CESC	0.00036	Kaplan-Meier Survival Analysis
LAML	0.0065	Kaplan-Meier Survival Analysis
GBM	0.00014	Kaplan-Meier Survival Analysis
LUAD	0.026	Kaplan-Meier Survival Analysis
UVM	0.00027	Kaplan-Meier Survival Analysis
OV	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000172183 (Gene tree)
Gene ID: 3669
Gene Symbol: ISG20
Alias: HEM45|CD25
Full Name: interferon stimulated exonuclease gene 20
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 20,862 bases
Position: chr15:88,635,622-88,656,483
Accession: 6130
Summary: (Interferon Stimulated Exonuclease Gene 20) is a Protein Coding gene. Diseases associated with ISG20 include Hepatitis C Virus and Systemic Lupus Erythematosus. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5'-exoribonuclease activity. An important paralog of this gene is AEN.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000306565	RNase_T	PF00929.24	8.4e-12	1	1
ENSP00000453638	RNase_T	PF00929.24	8.4e-12	1	1
ENSP00000453666	RNase_T	PF00929.24	2.1e-07	1	1
ENSP00000368526	RNase_T	PF00929.24	0.00028	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28399146	Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA.	PLoS Pathog	2017 Apr 11	Liu Y	doi: 10.1371/journal.ppat.1006296

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000560573	ISG20-209	2698	-	-	- (aa)	-	-
ENST00000379224	ISG20-202	540	-	ENSP00000368526	87 (aa)	-	H3BLY5
ENST00000546338	ISG20-203	481	-	-	- (aa)	-	-
ENST00000558992	ISG20-207	190	-	-	- (aa)	-	-
ENST00000558236	ISG20-205	260	-	-	- (aa)	-	-
ENST00000558942	ISG20-206	2644	-	-	- (aa)	-	-
ENST00000306072	ISG20-201	1856	XM_005254899	ENSP00000306565	181 (aa)	XP_005254956	Q96AZ6
ENST00000560741	ISG20-210	800	XM_006720488	ENSP00000453638	181 (aa)	XP_006720551	Q96AZ6
ENST00000557824	ISG20-204	5634	-	-	- (aa)	-	-
ENST00000560746	ISG20-211	730	-	-	- (aa)	-	-
ENST00000559876	ISG20-208	614	XM_017022148	ENSP00000453666	155 (aa)	XP_016877637	H0YMM4

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000172183	Creatinine	9.8340000E-005	-
ENSG00000172183	monocyte chemoattractant protein 1 (66-77)	2.8860000E-005	-
ENSG00000172183	monocyte chemoattractant protein 1 (66-77)	6.9870000E-005	-
ENSG00000172183	Blood Pressure	5E-6	23251661
ENSG00000172183	Dupuytren Contracture	8E-7	21732829
ENSG00000172183	Age-Related Hearing Impairment 1	4E-11	27764096
ENSG00000172183	Age-Related Hearing Impairment 1	3E-13	27764096

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172183	rs58383894	15	88654277	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172183's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172183	ISG20	94	78.947	ENSAMEG00000012803	ISG20	100	78.947	Ailuropoda_melanoleuca
ENSG00000172183	ISG20	82	58.333	ENSACIG00000012040	isg20	71	46.552	Amphilophus_citrinellus
ENSG00000172183	ISG20	80	56.338	ENSACAG00000013905	-	60	40.964	Anolis_carolinensis
ENSG00000172183	ISG20	93	79.290	ENSBTAG00000014762	ISG20	99	79.290	Bos_taurus
ENSG00000172183	ISG20	100	95.580	ENSCJAG00000034923	ISG20	100	95.580	Callithrix_jacchus
ENSG00000172183	ISG20	94	80.702	ENSCAFG00000011525	ISG20	100	80.702	Canis_familiaris
ENSG00000172183	ISG20	94	80.702	ENSCAFG00020018837	ISG20	100	80.702	Canis_lupus_dingo
ENSG00000172183	ISG20	93	79.882	ENSCHIG00000014526	ISG20	99	79.882	Capra_hircus
ENSG00000172183	ISG20	100	85.635	ENSTSYG00000030528	ISG20	100	85.635	Carlito_syrichta
ENSG00000172183	ISG20	100	81.768	ENSCAPG00000011672	ISG20	100	81.768	Cavia_aperea
ENSG00000172183	ISG20	100	81.215	ENSCPOG00000036489	ISG20	100	81.215	Cavia_porcellus
ENSG00000172183	ISG20	100	95.028	ENSCCAG00000025395	ISG20	100	95.028	Cebus_capucinus
ENSG00000172183	ISG20	100	97.790	ENSCATG00000042494	ISG20	100	97.790	Cercocebus_atys
ENSG00000172183	ISG20	100	81.768	ENSCLAG00000008100	ISG20	100	81.768	Chinchilla_lanigera
ENSG00000172183	ISG20	100	96.685	ENSCSAG00000017194	ISG20	100	96.685	Chlorocebus_sabaeus
ENSG00000172183	ISG20	87	37.195	ENSCING00000004431	-	81	37.195	Ciona_intestinalis
ENSG00000172183	ISG20	100	98.343	ENSCANG00000032616	ISG20	100	98.343	Colobus_angolensis_palliatus
ENSG00000172183	ISG20	99	84.066	ENSCGRG00001016300	-	98	87.413	Cricetulus_griseus_chok1gshd
ENSG00000172183	ISG20	99	84.066	ENSCGRG00000000609	-	99	84.066	Cricetulus_griseus_crigri
ENSG00000172183	ISG20	90	49.390	ENSCVAG00000009300	isg20	76	49.383	Cyprinodon_variegatus
ENSG00000172183	ISG20	92	46.707	ENSDARG00000102266	isg20l2	52	46.707	Danio_rerio
ENSG00000172183	ISG20	99	78.889	ENSDNOG00000049229	ISG20	99	78.889	Dasypus_novemcinctus
ENSG00000172183	ISG20	94	46.512	ENSEBUG00000009658	-	83	46.512	Eptatretus_burgeri
ENSG00000172183	ISG20	85	49.333	ENSEBUG00000010461	ISG20	58	45.062	Eptatretus_burgeri
ENSG00000172183	ISG20	93	80.473	ENSEASG00005015360	ISG20	99	80.473	Equus_asinus_asinus
ENSG00000172183	ISG20	93	81.065	ENSECAG00000019499	ISG20	99	81.065	Equus_caballus
ENSG00000172183	ISG20	94	80.117	ENSFCAG00000005151	ISG20	100	80.117	Felis_catus
ENSG00000172183	ISG20	100	81.768	ENSFDAG00000007444	ISG20	100	81.768	Fukomys_damarensis
ENSG00000172183	ISG20	87	49.057	ENSFHEG00000018658	isg20	69	44.915	Fundulus_heteroclitus
ENSG00000172183	ISG20	82	55.556	ENSGMOG00000001258	isg20	73	46.541	Gadus_morhua
ENSG00000172183	ISG20	88	50.000	ENSGALG00000044204	ISG20	64	50.000	Gallus_gallus
ENSG00000172183	ISG20	88	50.932	ENSGAFG00000005685	isg20	72	50.932	Gambusia_affinis
ENSG00000172183	ISG20	85	56.000	ENSGACG00000007047	isg20	50	50.000	Gasterosteus_aculeatus
ENSG00000172183	ISG20	92	59.880	ENSGAGG00000013542	ISG20	96	59.880	Gopherus_agassizii
ENSG00000172183	ISG20	100	100.000	ENSGGOG00000010365	ISG20	100	100.000	Gorilla_gorilla
ENSG00000172183	ISG20	100	82.873	ENSHGLG00000009077	ISG20	100	82.873	Heterocephalus_glaber_female
ENSG00000172183	ISG20	100	83.425	ENSHGLG00100005004	ISG20	100	83.425	Heterocephalus_glaber_male
ENSG00000172183	ISG20	88	48.125	ENSHCOG00000013913	isg20l2	78	45.517	Hippocampus_comes
ENSG00000172183	ISG20	99	84.358	ENSSTOG00000020467	ISG20	99	84.358	Ictidomys_tridecemlineatus
ENSG00000172183	ISG20	99	83.333	ENSJJAG00000010531	-	99	83.333	Jaculus_jaculus
ENSG00000172183	ISG20	88	48.125	ENSLACG00000018339	-	57	48.125	Latimeria_chalumnae
ENSG00000172183	ISG20	90	49.693	ENSLOCG00000014240	isg20	73	49.693	Lepisosteus_oculatus
ENSG00000172183	ISG20	100	97.790	ENSMFAG00000032331	ISG20	100	97.790	Macaca_fascicularis
ENSG00000172183	ISG20	100	97.790	ENSMMUG00000007669	ISG20	100	97.790	Macaca_mulatta
ENSG00000172183	ISG20	100	97.790	ENSMNEG00000030310	ISG20	100	97.790	Macaca_nemestrina
ENSG00000172183	ISG20	100	97.790	ENSMLEG00000038761	ISG20	100	97.790	Mandrillus_leucophaeus
ENSG00000172183	ISG20	99	80.769	ENSMAUG00000015001	-	99	80.769	Mesocricetus_auratus
ENSG00000172183	ISG20	98	83.721	ENSMICG00000027508	ISG20	100	87.135	Microcebus_murinus
ENSG00000172183	ISG20	97	79.429	ENSMOCG00000005940	-	99	79.429	Microtus_ochrogaster
ENSG00000172183	ISG20	91	55.422	ENSMMOG00000019013	isg20	86	55.422	Mola_mola
ENSG00000172183	ISG20	91	68.293	ENSMODG00000019583	ISG20	93	68.293	Monodelphis_domestica
ENSG00000172183	ISG20	100	81.215	MGP_CAROLIEiJ_G0029873	-	99	83.333	Mus_caroli
ENSG00000172183	ISG20	100	81.768	ENSMUSG00000039236	Isg20	99	84.028	Mus_musculus
ENSG00000172183	ISG20	100	81.215	MGP_PahariEiJ_G0013095	-	99	83.333	Mus_pahari
ENSG00000172183	ISG20	100	81.215	MGP_SPRETEiJ_G0030975	-	99	83.333	Mus_spretus
ENSG00000172183	ISG20	94	70.760	ENSMPUG00000015816	ISG20	100	70.760	Mustela_putorius_furo
ENSG00000172183	ISG20	94	86.550	ENSNGAG00000019782	-	97	86.550	Nannospalax_galili
ENSG00000172183	ISG20	91	97.561	ENSNLEG00000033379	ISG20	100	97.561	Nomascus_leucogenys
ENSG00000172183	ISG20	99	81.111	ENSODEG00000015032	ISG20	99	81.111	Octodon_degus
ENSG00000172183	ISG20	86	57.333	ENSONIG00000001534	isg20l2	88	49.383	Oreochromis_niloticus
ENSG00000172183	ISG20	89	67.949	ENSOANG00000006380	ISG20	79	67.586	Ornithorhynchus_anatinus
ENSG00000172183	ISG20	100	83.425	ENSOCUG00000023346	ISG20	100	83.425	Oryctolagus_cuniculus
ENSG00000172183	ISG20	96	46.857	ENSORLG00000029585	isg20	84	46.857	Oryzias_latipes
ENSG00000172183	ISG20	97	47.159	ENSORLG00015016089	isg20	74	47.159	Oryzias_latipes_hsok
ENSG00000172183	ISG20	95	44.970	ENSOMEG00000003990	isg20	97	45.930	Oryzias_melastigma
ENSG00000172183	ISG20	94	88.889	ENSOGAG00000004742	ISG20	100	88.889	Otolemur_garnettii
ENSG00000172183	ISG20	89	80.519	ENSOARG00000010964	ISG20	95	67.241	Ovis_aries
ENSG00000172183	ISG20	100	98.343	ENSPPAG00000028868	ISG20	100	98.343	Pan_paniscus
ENSG00000172183	ISG20	94	80.702	ENSPPRG00000023560	ISG20	100	80.702	Panthera_pardus
ENSG00000172183	ISG20	89	79.221	ENSPTIG00000018498	ISG20	71	81.159	Panthera_tigris_altaica
ENSG00000172183	ISG20	100	100.000	ENSPTRG00000044668	ISG20	100	100.000	Pan_troglodytes
ENSG00000172183	ISG20	100	97.238	ENSPANG00000034658	ISG20	100	97.238	Papio_anubis
ENSG00000172183	ISG20	85	53.333	ENSPMGG00000021232	isg20	79	46.914	Periophthalmus_magnuspinnatus
ENSG00000172183	ISG20	99	81.868	ENSPEMG00000020302	-	99	81.868	Peromyscus_maniculatus_bairdii
ENSG00000172183	ISG20	87	45.912	ENSPMAG00000000577	isg20	87	45.912	Petromyzon_marinus
ENSG00000172183	ISG20	89	53.846	ENSPMAG00000001569	ISG20	90	48.485	Petromyzon_marinus
ENSG00000172183	ISG20	91	68.485	ENSPCIG00000006405	ISG20	88	68.485	Phascolarctos_cinereus
ENSG00000172183	ISG20	88	50.311	ENSPLAG00000005932	isg20	78	48.701	Poecilia_latipinna
ENSG00000172183	ISG20	88	50.311	ENSPMEG00000016899	isg20	72	50.311	Poecilia_mexicana
ENSG00000172183	ISG20	82	55.556	ENSPREG00000005954	isg20	64	51.079	Poecilia_reticulata
ENSG00000172183	ISG20	100	99.448	ENSPPYG00000006756	ISG20	100	99.448	Pongo_abelii
ENSG00000172183	ISG20	98	82.353	ENSPCOG00000015727	ISG20	98	82.353	Propithecus_coquereli
ENSG00000172183	ISG20	97	80.114	ENSRNOG00000054561	Isg20	99	80.702	Rattus_norvegicus
ENSG00000172183	ISG20	100	97.790	ENSRBIG00000041506	ISG20	100	97.790	Rhinopithecus_bieti
ENSG00000172183	ISG20	100	97.790	ENSRROG00000043326	ISG20	100	97.790	Rhinopithecus_roxellana
ENSG00000172183	ISG20	100	94.475	ENSSBOG00000031539	ISG20	100	94.475	Saimiri_boliviensis_boliviensis
ENSG00000172183	ISG20	92	69.880	ENSSHAG00000017049	ISG20	97	69.880	Sarcophilus_harrisii
ENSG00000172183	ISG20	82	58.333	ENSSMAG00000004520	isg20	50	50.314	Scophthalmus_maximus
ENSG00000172183	ISG20	92	63.473	ENSSPUG00000012061	ISG20	97	63.473	Sphenodon_punctatus
ENSG00000172183	ISG20	93	80.473	ENSSSCG00000024867	ISG20	99	80.473	Sus_scrofa
ENSG00000172183	ISG20	83	53.289	ENSTNIG00000010389	isg20	75	53.289	Tetraodon_nigroviridis
ENSG00000172183	ISG20	89	80.519	ENSUAMG00000019065	ISG20	97	77.931	Ursus_americanus
ENSG00000172183	ISG20	94	81.287	ENSVVUG00000012013	ISG20	100	81.287	Vulpes_vulpes
ENSG00000172183	ISG20	88	51.875	ENSXETG00000007588	aen	63	51.875	Xenopus_tropicalis
ENSG00000172183	ISG20	95	49.133	ENSXMAG00000013066	isg20	55	49.133	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	11401564.	IDA	Function
GO:0000738	DNA catabolic process, exonucleolytic	11401564.	IDA	Process
GO:0004527	exonuclease activity	21036379.	IMP	Function
GO:0005634	nucleus	21036379.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	16514659.	IDA	Component
GO:0005737	cytoplasm	16514659.21036379.	IDA	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0006401	RNA catabolic process	11401564.	IDA	Process
GO:0008283	cell proliferation	9569007.	TAS	Process
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	11401564.	IDA	Function
GO:0008859	exoribonuclease II activity	-	IEA	Function
GO:0009615	response to virus	12594219.	IDA	Process
GO:0015030	Cajal body	16514659.	IDA	Component
GO:0016605	PML body	9235947.	IDA	Component
GO:0030619	U1 snRNA binding	16514659.	IDA	Function
GO:0030620	U2 snRNA binding	16514659.	IDA	Function
GO:0034511	U3 snoRNA binding	16514659.	IDA	Function
GO:0045071	negative regulation of viral genome replication	21036379.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051607	defense response to virus	21036379.	IMP	Process
GO:0060337	type I interferon signaling pathway	-	TAS	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.