EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29195126Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer.Neoplasia2018 JanLin SLdoi: 10.1016/j.neo.2017.10.007

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1588652210Missense_MutationnovelT110R0.25
BLCAchr1588639502Missense_Mutationrs770868397E46Q0.13RNase_T
BLCAchr1588639456Silentrs144037981L30L0.42
BRCAchr15886555443'UTRrs7737068770.29
BRCAchr15886555443'UTRrs7737068770.33
BRCAchr1588651925Intronnovel0.13
BRCAchr15886555553'UTRnovel0.15
COADchr1588651966Intronnovel0.35
COADchr15886556303'UTRnovel0.67
COADchr1588655424Missense_MutationnovelL147F0.5
COADchr1588639548Missense_Mutationrs371941091P61H0.28RNase_T
ESCAchr1588652080Intronnovel0.28
ESCAchr1588652202Missense_MutationnovelI107M0.16
ESCAchr1588639508Missense_MutationnovelE48Q0.19RNase_T
GBMchr1588639445Missense_Mutationrs752810937R27C0.56RNase_T
GBMchr15886556093'UTRnovel0.4
HNSCchr1588652260Missense_Mutationrs781386863R127C0.12
LIHCchr1588639378SilentNAS4S0.73
LUADchr1588655438SilentNAS151S0.49
LUADchr1588652280SilentnovelL133L0.21
LUADchr1588655512Missense_Mutationrs748762729R176H0.22
LUSCchr15886556493'UTRnovel0.27
LUSCchr1588639504Missense_MutationNAE46D0.11RNase_T
LUSCchr1588655455Missense_Mutationrs769145683A157V0.15
OVchr15886555663'UTRnovel0.5
READchr1588652234Missense_Mutationrs549880749R118H0.2
SKCMchr15886555563'UTRnovel0.38
SKCMchr15886555703'UTRrs7528176500.39
SKCMchr1588652077Intronnovel0.37
SKCMchr1588639492SilentNAF42F0.16
SKCMchr1588652049Intronnovel0.36
SKCMchr1588652240Missense_MutationNAA120V0.18
STADchr1588652225Missense_MutationNAL115R0.31
STADchr1588652273Missense_Mutationrs771930617R131Q0.36
STADchr1588652272Missense_Mutationrs747830918R131W0.16
UCECchr1588639575Missense_MutationNAF70C0.27RNase_T
UCECchr1588655499Nonsense_Mutationrs369479597R172*0.32
UCECchr1588655449Missense_MutationnovelA155V0.44
UCECchr1588652210Missense_Mutationrs772920253T110M0.46
UCECchr15886556463'UTRnovel0.44
UCECchr1588639456Silentrs144037981L30L0.56
UCECchr1588655507SilentnovelL174L0.1
UCECchr1588651809Intronnovel0.39
UCECchr1588652116Nonsense_Mutationrs531794921Q79*0.49
UCECchr1588652206Missense_MutationNAD109N0.29
UCECchr1588652287Missense_Mutationrs760289978R136C0.4
UCECchr1588651796Intronnovel0.3
UCECchr1588652261Missense_Mutationrs149381576R127H0.41
UCSchr1588655479Missense_MutationNAS165F0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.21690.0058042
LGGAMP0.02140.19963
LIHCDEL0.17030.056724
PAADAMP0.07610.20695
PAADDEL0.10330.13216
SKCMAMP0.24529.6912e-06

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

SARC0.013

Kaplan-Meier Survival Analysis

MESO0.018

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

HNSC0.019

Kaplan-Meier Survival Analysis

SKCM0.00094

Kaplan-Meier Survival Analysis

BRCA0.011

Kaplan-Meier Survival Analysis

KIRP0.0099

Kaplan-Meier Survival Analysis

COAD0.041

Kaplan-Meier Survival Analysis

PAAD0.043

Kaplan-Meier Survival Analysis

BLCA0.022

Kaplan-Meier Survival Analysis

CESC0.00036

Kaplan-Meier Survival Analysis

LAML0.0065

Kaplan-Meier Survival Analysis

GBM0.00014

Kaplan-Meier Survival Analysis

LUAD0.026

Kaplan-Meier Survival Analysis

UVM0.00027

Kaplan-Meier Survival Analysis

OV0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000172183 (Gene tree)
Gene ID
3669
Gene Symbol
ISG20
Alias
HEM45|CD25
Full Name
interferon stimulated exonuclease gene 20
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
20,862 bases
Position
chr15:88,635,622-88,656,483
Accession
6130
RBP type
canonical RBP
Summary
(Interferon Stimulated Exonuclease Gene 20) is a Protein Coding gene. Diseases associated with ISG20 include Hepatitis C Virus and Systemic Lupus Erythematosus. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5'-exoribonuclease activity. An important paralog of this gene is AEN.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000306565RNase_TPF00929.248.4e-1211
ENSP00000453638RNase_TPF00929.248.4e-1211
ENSP00000453666RNase_TPF00929.242.1e-0711
ENSP00000368526RNase_TPF00929.240.0002811

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28399146Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA.PLoS Pathog2017 Apr 11Liu Ydoi: 10.1371/journal.ppat.1006296
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000560573ISG20-2092698--- (aa)--
ENST00000379224ISG20-202540-ENSP0000036852687 (aa)-H3BLY5
ENST00000546338ISG20-203481--- (aa)--
ENST00000558992ISG20-207190--- (aa)--
ENST00000558236ISG20-205260--- (aa)--
ENST00000558942ISG20-2062644--- (aa)--
ENST00000306072ISG20-2011856XM_005254899ENSP00000306565181 (aa)XP_005254956Q96AZ6
ENST00000560741ISG20-210800XM_006720488ENSP00000453638181 (aa)XP_006720551Q96AZ6
ENST00000557824ISG20-2045634--- (aa)--
ENST00000560746ISG20-211730--- (aa)--
ENST00000559876ISG20-208614XM_017022148ENSP00000453666155 (aa)XP_016877637H0YMM4
Gene Model
Click here to download ENSG00000172183's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000172183Creatinine9.8340000E-005-
ENSG00000172183monocyte chemoattractant protein 1 (66-77)2.8860000E-005-
ENSG00000172183monocyte chemoattractant protein 1 (66-77)6.9870000E-005-
ENSG00000172183Blood Pressure5E-623251661
ENSG00000172183Dupuytren Contracture8E-721732829
ENSG00000172183Age-Related Hearing Impairment 14E-1127764096
ENSG00000172183Age-Related Hearing Impairment 13E-1327764096
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000172183rs583838941588654277?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172183's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000172183ISG209478.947ENSAMEG00000012803ISG2010078.947Ailuropoda_melanoleuca
ENSG00000172183ISG208258.333ENSACIG00000012040isg207146.552Amphilophus_citrinellus
ENSG00000172183ISG208056.338ENSACAG00000013905-6040.964Anolis_carolinensis
ENSG00000172183ISG209379.290ENSBTAG00000014762ISG209979.290Bos_taurus
ENSG00000172183ISG2010095.580ENSCJAG00000034923ISG2010095.580Callithrix_jacchus
ENSG00000172183ISG209480.702ENSCAFG00000011525ISG2010080.702Canis_familiaris
ENSG00000172183ISG209480.702ENSCAFG00020018837ISG2010080.702Canis_lupus_dingo
ENSG00000172183ISG209379.882ENSCHIG00000014526ISG209979.882Capra_hircus
ENSG00000172183ISG2010085.635ENSTSYG00000030528ISG2010085.635Carlito_syrichta
ENSG00000172183ISG2010081.768ENSCAPG00000011672ISG2010081.768Cavia_aperea
ENSG00000172183ISG2010081.215ENSCPOG00000036489ISG2010081.215Cavia_porcellus
ENSG00000172183ISG2010095.028ENSCCAG00000025395ISG2010095.028Cebus_capucinus
ENSG00000172183ISG2010097.790ENSCATG00000042494ISG2010097.790Cercocebus_atys
ENSG00000172183ISG2010081.768ENSCLAG00000008100ISG2010081.768Chinchilla_lanigera
ENSG00000172183ISG2010096.685ENSCSAG00000017194ISG2010096.685Chlorocebus_sabaeus
ENSG00000172183ISG208737.195ENSCING00000004431-8137.195Ciona_intestinalis
ENSG00000172183ISG2010098.343ENSCANG00000032616ISG2010098.343Colobus_angolensis_palliatus
ENSG00000172183ISG209984.066ENSCGRG00001016300-9887.413Cricetulus_griseus_chok1gshd
ENSG00000172183ISG209984.066ENSCGRG00000000609-9984.066Cricetulus_griseus_crigri
ENSG00000172183ISG209049.390ENSCVAG00000009300isg207649.383Cyprinodon_variegatus
ENSG00000172183ISG209246.707ENSDARG00000102266isg20l25246.707Danio_rerio
ENSG00000172183ISG209978.889ENSDNOG00000049229ISG209978.889Dasypus_novemcinctus
ENSG00000172183ISG209446.512ENSEBUG00000009658-8346.512Eptatretus_burgeri
ENSG00000172183ISG208549.333ENSEBUG00000010461ISG205845.062Eptatretus_burgeri
ENSG00000172183ISG209380.473ENSEASG00005015360ISG209980.473Equus_asinus_asinus
ENSG00000172183ISG209381.065ENSECAG00000019499ISG209981.065Equus_caballus
ENSG00000172183ISG209480.117ENSFCAG00000005151ISG2010080.117Felis_catus
ENSG00000172183ISG2010081.768ENSFDAG00000007444ISG2010081.768Fukomys_damarensis
ENSG00000172183ISG208749.057ENSFHEG00000018658isg206944.915Fundulus_heteroclitus
ENSG00000172183ISG208255.556ENSGMOG00000001258isg207346.541Gadus_morhua
ENSG00000172183ISG208850.000ENSGALG00000044204ISG206450.000Gallus_gallus
ENSG00000172183ISG208850.932ENSGAFG00000005685isg207250.932Gambusia_affinis
ENSG00000172183ISG208556.000ENSGACG00000007047isg205050.000Gasterosteus_aculeatus
ENSG00000172183ISG209259.880ENSGAGG00000013542ISG209659.880Gopherus_agassizii
ENSG00000172183ISG20100100.000ENSGGOG00000010365ISG20100100.000Gorilla_gorilla
ENSG00000172183ISG2010082.873ENSHGLG00000009077ISG2010082.873Heterocephalus_glaber_female
ENSG00000172183ISG2010083.425ENSHGLG00100005004ISG2010083.425Heterocephalus_glaber_male
ENSG00000172183ISG208848.125ENSHCOG00000013913isg20l27845.517Hippocampus_comes
ENSG00000172183ISG209984.358ENSSTOG00000020467ISG209984.358Ictidomys_tridecemlineatus
ENSG00000172183ISG209983.333ENSJJAG00000010531-9983.333Jaculus_jaculus
ENSG00000172183ISG208848.125ENSLACG00000018339-5748.125Latimeria_chalumnae
ENSG00000172183ISG209049.693ENSLOCG00000014240isg207349.693Lepisosteus_oculatus
ENSG00000172183ISG2010097.790ENSMFAG00000032331ISG2010097.790Macaca_fascicularis
ENSG00000172183ISG2010097.790ENSMMUG00000007669ISG2010097.790Macaca_mulatta
ENSG00000172183ISG2010097.790ENSMNEG00000030310ISG2010097.790Macaca_nemestrina
ENSG00000172183ISG2010097.790ENSMLEG00000038761ISG2010097.790Mandrillus_leucophaeus
ENSG00000172183ISG209980.769ENSMAUG00000015001-9980.769Mesocricetus_auratus
ENSG00000172183ISG209883.721ENSMICG00000027508ISG2010087.135Microcebus_murinus
ENSG00000172183ISG209779.429ENSMOCG00000005940-9979.429Microtus_ochrogaster
ENSG00000172183ISG209155.422ENSMMOG00000019013isg208655.422Mola_mola
ENSG00000172183ISG209168.293ENSMODG00000019583ISG209368.293Monodelphis_domestica
ENSG00000172183ISG2010081.215MGP_CAROLIEiJ_G0029873-9983.333Mus_caroli
ENSG00000172183ISG2010081.768ENSMUSG00000039236Isg209984.028Mus_musculus
ENSG00000172183ISG2010081.215MGP_PahariEiJ_G0013095-9983.333Mus_pahari
ENSG00000172183ISG2010081.215MGP_SPRETEiJ_G0030975-9983.333Mus_spretus
ENSG00000172183ISG209470.760ENSMPUG00000015816ISG2010070.760Mustela_putorius_furo
ENSG00000172183ISG209486.550ENSNGAG00000019782-9786.550Nannospalax_galili
ENSG00000172183ISG209197.561ENSNLEG00000033379ISG2010097.561Nomascus_leucogenys
ENSG00000172183ISG209981.111ENSODEG00000015032ISG209981.111Octodon_degus
ENSG00000172183ISG208657.333ENSONIG00000001534isg20l28849.383Oreochromis_niloticus
ENSG00000172183ISG208967.949ENSOANG00000006380ISG207967.586Ornithorhynchus_anatinus
ENSG00000172183ISG2010083.425ENSOCUG00000023346ISG2010083.425Oryctolagus_cuniculus
ENSG00000172183ISG209646.857ENSORLG00000029585isg208446.857Oryzias_latipes
ENSG00000172183ISG209747.159ENSORLG00015016089isg207447.159Oryzias_latipes_hsok
ENSG00000172183ISG209544.970ENSOMEG00000003990isg209745.930Oryzias_melastigma
ENSG00000172183ISG209488.889ENSOGAG00000004742ISG2010088.889Otolemur_garnettii
ENSG00000172183ISG208980.519ENSOARG00000010964ISG209567.241Ovis_aries
ENSG00000172183ISG2010098.343ENSPPAG00000028868ISG2010098.343Pan_paniscus
ENSG00000172183ISG209480.702ENSPPRG00000023560ISG2010080.702Panthera_pardus
ENSG00000172183ISG208979.221ENSPTIG00000018498ISG207181.159Panthera_tigris_altaica
ENSG00000172183ISG20100100.000ENSPTRG00000044668ISG20100100.000Pan_troglodytes
ENSG00000172183ISG2010097.238ENSPANG00000034658ISG2010097.238Papio_anubis
ENSG00000172183ISG208553.333ENSPMGG00000021232isg207946.914Periophthalmus_magnuspinnatus
ENSG00000172183ISG209981.868ENSPEMG00000020302-9981.868Peromyscus_maniculatus_bairdii
ENSG00000172183ISG208745.912ENSPMAG00000000577isg208745.912Petromyzon_marinus
ENSG00000172183ISG208953.846ENSPMAG00000001569ISG209048.485Petromyzon_marinus
ENSG00000172183ISG209168.485ENSPCIG00000006405ISG208868.485Phascolarctos_cinereus
ENSG00000172183ISG208850.311ENSPLAG00000005932isg207848.701Poecilia_latipinna
ENSG00000172183ISG208850.311ENSPMEG00000016899isg207250.311Poecilia_mexicana
ENSG00000172183ISG208255.556ENSPREG00000005954isg206451.079Poecilia_reticulata
ENSG00000172183ISG2010099.448ENSPPYG00000006756ISG2010099.448Pongo_abelii
ENSG00000172183ISG209882.353ENSPCOG00000015727ISG209882.353Propithecus_coquereli
ENSG00000172183ISG209780.114ENSRNOG00000054561Isg209980.702Rattus_norvegicus
ENSG00000172183ISG2010097.790ENSRBIG00000041506ISG2010097.790Rhinopithecus_bieti
ENSG00000172183ISG2010097.790ENSRROG00000043326ISG2010097.790Rhinopithecus_roxellana
ENSG00000172183ISG2010094.475ENSSBOG00000031539ISG2010094.475Saimiri_boliviensis_boliviensis
ENSG00000172183ISG209269.880ENSSHAG00000017049ISG209769.880Sarcophilus_harrisii
ENSG00000172183ISG208258.333ENSSMAG00000004520isg205050.314Scophthalmus_maximus
ENSG00000172183ISG209263.473ENSSPUG00000012061ISG209763.473Sphenodon_punctatus
ENSG00000172183ISG209380.473ENSSSCG00000024867ISG209980.473Sus_scrofa
ENSG00000172183ISG208353.289ENSTNIG00000010389isg207553.289Tetraodon_nigroviridis
ENSG00000172183ISG208980.519ENSUAMG00000019065ISG209777.931Ursus_americanus
ENSG00000172183ISG209481.287ENSVVUG00000012013ISG2010081.287Vulpes_vulpes
ENSG00000172183ISG208851.875ENSXETG00000007588aen6351.875Xenopus_tropicalis
ENSG00000172183ISG209549.133ENSXMAG00000013066isg205549.133Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:00001753'-5'-exoribonuclease activity11401564.IDAFunction
GO:0000738DNA catabolic process, exonucleolytic11401564.IDAProcess
GO:0004527exonuclease activity21036379.IMPFunction
GO:0005634nucleus21036379.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus16514659.IDAComponent
GO:0005737cytoplasm16514659.21036379.IDAComponent
GO:0006364rRNA processing-IEAProcess
GO:0006401RNA catabolic process11401564.IDAProcess
GO:0008283cell proliferation9569007.TASProcess
GO:0008310single-stranded DNA 3'-5' exodeoxyribonuclease activity11401564.IDAFunction
GO:0008859exoribonuclease II activity-IEAFunction
GO:0009615response to virus12594219.IDAProcess
GO:0015030Cajal body16514659.IDAComponent
GO:0016605PML body9235947.IDAComponent
GO:0030619U1 snRNA binding16514659.IDAFunction
GO:0030620U2 snRNA binding16514659.IDAFunction
GO:0034511U3 snoRNA binding16514659.IDAFunction
GO:0045071negative regulation of viral genome replication21036379.IMPProcess
GO:0046872metal ion binding-IEAFunction
GO:0051607defense response to virus21036379.IMPProcess
GO:0060337type I interferon signaling pathway-TASProcess
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic-IEAProcess
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