EuRBPDB

Ensembl ID

ENSG00000171634 (Gene tree)

Gene ID

2186

Gene Symbol

BPTF

Alias

FAC1|NURF301|FALZ

Full Name

bromodomain PHD finger transcription factor

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Plus strand

Length

158,855 bases

Position

chr17:67,825,524-67,984,378

Accession

3581

Summary

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]