EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28291803	Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.	PLoS One	2017 Mar 14	Kudryavtsev VA	doi: 10.1371/journal.pone.0173640
18426646	[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance].	Zhongguo Shi Yan Xue Ye Xue Za Zhi	2008 Apr	Li Y	-
17616937	Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.	Histol Histopathol	2007 Oct	Ramp U	doi: 10.14670/HH-22.1099.
18587674	HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer.	Mol Biotechnol	2008 Nov	Liu Q	doi: 10.1007/s12033-008-9080-5
22613557	Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells.	FEBS J	2012 Jul	Sokolowska I	doi: 10.1111/j.1742-4658.2012.08641.x
18790094	cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.	Biochim Biophys Acta	2008 Dec	Russo A	doi: 10.1016/j.bbagrm.2008.08.006
22037021	Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.	Biochimie	2012 Jan	Yashin DV	doi: 10.1016/j.biochi.2011.10.007
17278882	Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells.	Cell Stress Chaperones	2006 Winter	Melendez K	-
19069644	[Synergistic effect of thermotherapy in combination with chemotherapy on lung tumor A549 cells growth through activation of c-Jun N-terminal kinase and inhibition of heat shock protein70 expression].	Wei Sheng Yan Jiu	2008 Sep	Gao S	-
17580361	Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.	Cancer	2007 Aug 15	Pfister K	-
25347739	Hsp70 in cancer: back to the future.	Oncogene	2015 Aug 6	Sherman MY	doi: 10.1038/onc.2014.349
20714862	Expression of Hsp27 and Hsp70 in lymphocytes and plasma in healthy workers and coal miners with lung cancer.	J Huazhong Univ Sci Technolog Med Sci	2010 Aug	Wang H	doi: 10.1007/s11596-010-0441-5
26559972	A Novel Function of Molecular Chaperone HSP70: SUPPRESSION OF ONCOGENIC FOXM1 AFTER PROTEOTOXIC STRESS.	J Biol Chem	2016 Jan 1	Halasi M	doi: 10.1074/jbc.M115.678227
19635199	[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics].	Ai Zheng	2009 Jun	Zhang WL	-
15378924	Content and synthesis of stress proteins in subcellular structures of cancer cells exposed to heat shock and cisplatin.	Dokl Biochem Biophys	2004 May-Jun	Mavletova DA	-
21725599	ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth.	Mol Med Rep	2011 Sep-Oct	Zhong MA	doi: 10.3892/mmr.2011.528
25175595	Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor.	BMC Cancer	2014 Aug 30	Lin Y	doi: 10.1186/1471-2407-14-639.
22535481	High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer.	Cell Oncol (Dordr)	2012 Jun	Bauer K	doi: 10.1007/s13402-012-0079-3
26050647	Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression.	Clin Lung Cancer	2015 Nov	Lee SH	doi: 10.1016/j.cllc.2015.05.006
24501795	[Analysis of occurrence atypical proteins in the serum at smoking and non-smoking cigarettes patients with lung cancer].	Przegl Lek	2013	Goda R	-
26556859	Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.	Oncotarget	2015 Nov 24	Cavanaugh A	doi: 10.18632/oncotarget.5496.
28192510	Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer.	PLoS One	2017 Feb 13	Arora N	doi: 10.1371/journal.pone.0171827
28848092	Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells.	Cell Physiol Biochem	2017	Somensi N	doi: 10.1159/000480213
30245753	Circulating Heat Shock Protein 70 Is a Novel Biomarker for Early Diagnosis of Lung Cancer.	Dis Markers	2018 Aug 29	Tang T	doi: 10.1155/2018/6184162
30337218	Heat shock proteins 60 and 70 are associated with long-term outcome of T1-stage high-grade urothelial tumors of the bladder treated with intravesical Bacillus Calmette-Gu??rin immunotherapy.	Urol Oncol	2018 Dec	Mano R	doi: 10.1016/j.urolonc.2018.09.007

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	133091354	Nonsense_Mutation	novel	Q514*	0.28
BLCA	chr5	133091333	Missense_Mutation	novel	E507K	0.24
BLCA	chr5	133104505	3'UTR	novel		0.38
BLCA	chr5	133089084	Silent	novel	V389V	0.17
BLCA	chr5	133067516	Missense_Mutation	novel	Y89H	0.27
BRCA	chr5	133089111	Silent	NA	V398V	0.18
BRCA	chr5	133067505	Missense_Mutation	NA	S85C	0.25
BRCA	chr5	133073255	Missense_Mutation	novel	E152V	0.39
BRCA	chr5	133076797	Missense_Mutation	NA	E269D	0.4
BRCA	chr5	133101805	Missense_Mutation	novel	R695L	0.07
BRCA	chr5	133067519	Missense_Mutation	NA	D90Y	0.24
BRCA	chr5	133089127	Silent	NA	L404L	0.28
BRCA	chr5	133076784	Missense_Mutation	NA	R265Q	0.11
BRCA	chr5	133086837	Missense_Mutation	rs368924343	R322C	0.13
BRCA	chr5	133097214	Silent	rs142002805	N619N	0.1
BRCA	chr5	133104305	In_Frame_Del	novel	K798_Q802del	0.32
CESC	chr5	133097214	Silent	rs142002805	N619N	0.38
CESC	chr5	133092699	Splice_Site	novel	X521_splice	0.87
CESC	chr5	133096250	Frame_Shift_Ins	novel	*G602Sfs3**	0.18
CESC	chr5	133088556	Splice_Site	novel	X379_splice	0.34
CESC	chr5	133103950	Missense_Mutation	novel	K748R	0.36
CESC	chr5	133092772	Missense_Mutation	NA	E545Q	0.49
CESC	chr5	133074040	Missense_Mutation	NA	E193K	0.14
COAD	chr5	133076735	Missense_Mutation	NA	G249R	0.49
COAD	chr5	133088499	Nonsense_Mutation	novel	E361*	0.33
COAD	chr5	133097250	Silent	novel	K631K	0.23
COAD	chr5	133089571	Silent	novel	E418E	0.26
COAD	chr5	133103911	Frame_Shift_Del	novel	*S737Afs9**	0.18
COAD	chr5	133076705	Missense_Mutation	NA	V239M	0.08
COAD	chr5	133086787	Missense_Mutation	NA	K305T	0.29
COAD	chr5	133089609	Missense_Mutation	novel	V431A	0.08
COAD	chr5	133088499	Nonsense_Mutation	novel	E361*	0.32
COAD	chr5	133065036	Nonsense_Mutation	novel	*Q55Hfs4**	0.05
GBM	chr5	133103951	Missense_Mutation	novel	K748N	0.06
GBM	chr5	133076886	Missense_Mutation	novel	G299E	0.31
GBM	chr5	133104419	Frame_Shift_Del	novel	*E836Kfs13**	0.09
GBM	chr5	133067494	Silent	novel	E81E	0.52
HNSC	chr5	133091353	Silent	novel	D513D	0.33
HNSC	chr5	133091354	Nonsense_Mutation	novel	Q514*	0.46
HNSC	chr5	133104404	Missense_Mutation	rs144576995	D831Y	0.18
HNSC	chr5	133104264	Nonsense_Mutation	novel	S784*	0.18
HNSC	chr5	133104396	Missense_Mutation	rs377082440	S828L	0.28
HNSC	chr5	133065032	Frame_Shift_Ins	novel	*S54Mfs6**	0.09
HNSC	chr5	133076770	Silent	NA	I260I	0.54
HNSC	chr5	133064991	Missense_Mutation	novel	S40C	0.17
KIRC	chr5	133052086	5'UTR	novel		0.39
KIRC	chr5	133103959	Missense_Mutation	NA	L751P	0.22
KIRC	chr5	133088463	Missense_Mutation	NA	A349S	0.27
KIRC	chr5	133104427	Silent	novel	D838D	0.09
LGG	chr5	133070452	Missense_Mutation	novel	A129T	0.33
LGG	chr5	133088555	Missense_Mutation	novel	Q379H	0.24
LIHC	chr5	133065000	Missense_Mutation	NA	P43L	0.15
LIHC	chr5	133104549	3'UTR	novel		0.33
LIHC	chr5	133104673	3'UTR	novel		0.57
LUAD	chr5	133103865	Nonsense_Mutation	novel	E720*	0.14
LUAD	chr5	133103963	Silent	novel	Q752Q	0.08
LUAD	chr5	133070479	In_Frame_Del	novel	D139_V142del	0.14
LUAD	chr5	133074095	Missense_Mutation	NA	S211F	0.11
LUAD	chr5	133067494	Missense_Mutation	novel	E81D	0.8
LUAD	chr5	133101809	Frame_Shift_Del	novel	*K697Nfs6**	0.33
LUAD	chr5	133088466	Missense_Mutation	NA	V350L	0.1
LUSC	chr5	133089118	Missense_Mutation	NA	P401S	0.13
LUSC	chr5	133070388	Silent	NA	E107E	0.24
LUSC	chr5	133074014	Missense_Mutation	NA	Y184C	0.84
LUSC	chr5	133074058	Missense_Mutation	novel	V199I	0.5
LUSC	chr5	133104457	3'UTR	novel		0.44
LUSC	chr5	133076772	Missense_Mutation	rs772742465	R261H	0.43
OV	chr5	133104246	Missense_Mutation	novel	T778N	0.2
PRAD	chr5	133091295	Missense_Mutation	rs141758444	S494N	0.29
PRAD	chr5	133089595	Frame_Shift_Del	novel	*P427Lfs2**	0.31
PRAD	chr5	133073279	Missense_Mutation	novel	T160I	0.48
PRAD	chr5	133101878	Missense_Mutation	novel	K719N	0.18
READ	chr5	133091262	Missense_Mutation	rs770551334	R483Q	0.2
READ	chr5	133088418	Missense_Mutation	NA	D334N	0.08
READ	chr5	133076812	Missense_Mutation	NA	K274N	0.42
READ	chr5	133088485	Missense_Mutation	novel	K356T	0.37
READ	chr5	133103967	Missense_Mutation	rs771075745	K754E	0.27
READ	chr5	133076792	Missense_Mutation	rs199586152	Q268E	0.59
SKCM	chr5	133073232	In_Frame_Del	novel	P145_D150del	0.07
SKCM	chr5	133065027	Missense_Mutation	NA	A52V	0.1
SKCM	chr5	133074123	Silent	novel	L220L	0.6
SKCM	chr5	133099572	Missense_Mutation	NA	E653K	0.22
SKCM	chr5	133089611	Missense_Mutation	NA	L432F	0.32
SKCM	chr5	133076770	Silent	NA	I260I	0.62
SKCM	chr5	133103980	Missense_Mutation	rs769795778	T758I	0.16
SKCM	chr5	133089611	Missense_Mutation	NA	L432F	0.38
STAD	chr5	133076796	Missense_Mutation	novel	E269V	0.13
STAD	chr5	133104303	Frame_Shift_Del	NA	*N799Mfs50**	0.2
STAD	chr5	133096203	Missense_Mutation	NA	L586V	0.18
STAD	chr5	133104303	Frame_Shift_Del	NA	*N799Mfs50**	0.27
STAD	chr5	133096156	Missense_Mutation	novel	A570E	0.5
STAD	chr5	133088455	Missense_Mutation	NA	R346Q	0.25
STAD	chr5	133092723	Silent	rs759663275	E528E	0.18
THCA	chr5	133065008	Missense_Mutation	NA	R46C	0.04
THCA	chr5	133091368	Nonsense_Mutation	novel	E518_E519ins*	0.07
THCA	chr5	133074038	In_Frame_Del	novel	E193_K194del	0.08
THYM	chr5	133096243	Missense_Mutation	novel	E599A	0.41
UCEC	chr5	133074118	Nonsense_Mutation	NA	K219*	0.29
UCEC	chr5	133065012	Missense_Mutation	NA	S47L	0.26
UCEC	chr5	133088547	Missense_Mutation	NA	A377T	0.25
UCEC	chr5	133089069	Silent	rs764891442	S384S	0.32
UCEC	chr5	133052269	Missense_Mutation	NA	D7Y	0.31
UCEC	chr5	133097212	Missense_Mutation	novel	N619H	0.3
UCEC	chr5	133088455	Missense_Mutation	NA	R346Q	0.43
UCEC	chr5	133067434	Missense_Mutation	novel	K61N	0.44
UCEC	chr5	133101761	Splice_Region	novel	N680N	0.33
UCEC	chr5	133099653	Splice_Site	novel	X679_splice	0.57
UCEC	chr5	133088485	Missense_Mutation	novel	K356T	0.04
UCEC	chr5	133076655	Missense_Mutation	NA	V222A	0.3
UCEC	chr5	133104310	Silent	NA	N799N	0.3
UCEC	chr5	133104361	Missense_Mutation	novel	Q816H	0.16
UCEC	chr5	133104396	Missense_Mutation	rs377082440	S828L	0.46
UCEC	chr5	133052322	Silent	novel	E24E	0.41
UCEC	chr5	133089088	Nonsense_Mutation	novel	E391*	0.5
UCEC	chr5	133074109	Missense_Mutation	NA	N216D	0.37
UCEC	chr5	133096221	Nonsense_Mutation	NA	E592*	0.4
UCEC	chr5	133111198	3'Flank	novel		0.38
UCEC	chr5	133091319	Missense_Mutation	novel	K502T	0.51
UCEC	chr5	133073291	Missense_Mutation	novel	G164D	0.28
UCEC	chr5	133104435	Silent	novel	*841*	0.32
UCEC	chr5	133096126	Missense_Mutation	novel	K560T	0.48
UCEC	chr5	133096212	Missense_Mutation	novel	I589V	0.23
UCEC	chr5	133111279	3'Flank	novel		0.35
UCEC	chr5	133096133	Silent	novel	D562D	0.34
UCEC	chr5	133070459	Missense_Mutation	novel	S131I	0.3
UCEC	chr5	133104280	Missense_Mutation	novel	K789N	0.7
UCEC	chr5	133104311	Missense_Mutation	NA	A800T	0.32
UCEC	chr5	133070396	Missense_Mutation	rs773711727	R110Q	0.43
UCEC	chr5	133103895	Missense_Mutation	novel	D730N	0.32
UCEC	chr5	133076677	Silent	rs751904979	T229T	0.24
UCEC	chr5	133089574	Silent	novel	V419V	0.32
UCEC	chr5	133088455	Missense_Mutation	NA	R346Q	0.47
UCEC	chr5	133103906	Missense_Mutation	novel	K733N	0.45
UCEC	chr5	133089593	Missense_Mutation	NA	A426S	0.23
UCEC	chr5	133076657	Missense_Mutation	novel	L223M	0.39
UCEC	chr5	133088538	Nonsense_Mutation	novel	R374*	0.44
UCEC	chr5	133091356	Silent	NA	Q514Q	0.5
UCEC	chr5	133065032	Missense_Mutation	NA	S54R	0.15
UCEC	chr5	133074052	Missense_Mutation	NA	N197Y	0.37
UCEC	chr5	133076812	Missense_Mutation	NA	K274N	0.24
UCEC	chr5	133103934	Missense_Mutation	novel	E743K	0.34
UCEC	chr5	133104344	Missense_Mutation	NA	D811Y	0.11
UCEC	chr5	133104396	Missense_Mutation	rs377082440	S828L	0.29
UCEC	chr5	133067540	Nonsense_Mutation	NA	G97*	0.3
UCEC	chr5	133104303	Frame_Shift_Del	NA	*N799Mfs50**	0.27
UCEC	chr5	133052015	5'UTR	novel		0.54
UCS	chr5	133088415	Nonsense_Mutation	novel	E333*	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUAD	DEL	0.3081	7.4776e-05
LUSC	DEL	0.6447	0.002071
MESO	DEL	0.1494	0.20184
PRAD	AMP	0.0264	0.16448
STAD	DEL	0.2789	2.8835e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0058	Kaplan-Meier Survival Analysis
UCS	0.007	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.0074	Kaplan-Meier Survival Analysis
KIRP	0.0082	Kaplan-Meier Survival Analysis
LAML	0.0097	Kaplan-Meier Survival Analysis
KICH	0.012	Kaplan-Meier Survival Analysis
GBM	0.029	Kaplan-Meier Survival Analysis
LIHC	0.00055	Kaplan-Meier Survival Analysis
LGG	0.0052	Kaplan-Meier Survival Analysis
LUAD	0.0003	Kaplan-Meier Survival Analysis
UVM	0.0074	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000170606 (Gene tree)
Gene ID: 3308
Gene Symbol: HSPA4
Alias: HS24/P52|HSPH2
Full Name: heat shock protein family A (Hsp70) member 4
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 54,488 bases
Position: chr5:133,051,962-133,106,449
Accession: 5237
Summary: (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Ischemia and Transient Cerebral Ischemia. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and Regulation of degradation of deltaF508 CFTR in CF. An important paralog of this gene is HSPA4L.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11720291	Analysis of sequence-specific binding of RNA to Hsp70 and its various homologs indicates the involvement of N- and C-terminal interactions.	RNA	2001 Nov	Zimmer C	-
7511613	RNA/protein interactions in the 5'-untranslated leader of HSP70 mRNA in Drosophila lysates. Lack of evidence for specific protein binding.	J Biol Chem	1994 Apr 8	Hess MA	-
11581272	Thermodynamics and kinetics of Hsp70 association with A + U-rich mRNA-destabilizing sequences.	J Biol Chem	2001 Nov 30	Wilson GM	-
18801074	Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight.	Pathol Int	2008 Sep	Baba T	doi: 10.1111/j.1440-1827.2008.02275.x.
28679534	Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions.	J Biol Chem	2017 Aug 25	Kishor A	doi: 10.1074/jbc.M117.785394
31293389	Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model.	Front Cell Neurosci	2019 Jun 25	Wowro SJ	doi: 10.3389/fncel.2019.00273
21732077	Differential expression of the transcripts of Spartina alterniflora Loisel (smooth cordgrass) induced in response to petroleum hydrocarbon.	Mol Biotechnol	2012 May	RamanaRao MV	doi: 10.1007/s12033-011-9436-0.
26386576	Expression of hsrOmega-RNAi transgene prior to heat shock specifically compromises accumulation of heat shock-induced Hsp70 in Drosophila melanogaster.	Cell Stress Chaperones	2016 Jan	Singh AK	doi: 10.1007/s12192-015-0644-6
10358092	Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability.	J Biol Chem	1999 Jun 11	Henics T	-
25498946	Leishmania braziliensis replication protein A subunit 1: molecular modelling, protein expression and analysis of its affinity for both DNA and RNA.	Parasit Vectors	2014 Dec 12	Nocua PA	doi: 10.1186/s13071-014-0573-8.
9722628	Specific binding of Drosophila nuclear protein PEP (protein on ecdysone puffs) to hsp70 DNA and RNA.	Nucleic Acids Res	1998 Sep 15	Hamann S	-
16563814	RNA delivery by heat shock protein-70 into mammalian cells: a preliminary study.	Cell Biol Int	2006 May	Henics T	-
16474124	Proteomics analysis of the tombusvirus replicase: Hsp70 molecular chaperone is associated with the replicase and enhances viral RNA replication.	J Virol	2006 Mar	Serva S	-
11359930	Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.	Mol Biol Cell	2001 May	Waelter S	-
15563614	Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content.	Plant Physiol	2004 Dec	Sjogren LL	-
19165146	Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.	EMBO J	2009 Mar 4	Katahira J	doi: 10.1038/emboj.2009.5
18991684	Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR.	Curr Pharm Des	2008	Amadio M	-
17913810	Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA binding.	J Virol	2007 Dec	Stahl M	-
17804463	Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system.	Nucleic Acids Res	2007	Stahl M	-
22058113	Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts.	Blood	2012 Jan 5	Horos R	doi: 10.1182/blood-2011-06-358200
20965275	Characterization of Hsp70 gene in Chironomus riparius: expression in response to endocrine disrupting pollutants as a marker of ecotoxicological stress.	Comp Biochem Physiol C Toxicol Pharmacol	2011 Jan	Morales M	doi: 10.1016/j.cbpc.2010.10.003
11599570	Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2.	Cell Stress Chaperones	2001 Jul	Fourie AM	-
24324328	Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes.	Drug Des Devel Ther	2013 Dec 2	Muhammad SI	doi: 10.2147/DDDT.S50861
15479789	Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis.	J Virol	2004 Nov	Brasier AR	-
2498651	Cortisol alters gene expression during involution of the rat ventral prostate.	Mol Endocrinol	1989 Apr	Rennie PS	-
9015264	Distinct stress-inducible and developmentally regulated heat shock transcription factors in Xenopus oocytes.	Dev Biol	1997 Jan 1	Gordon S	-
15735003	p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.	Cancer Res	2005 Feb 15	Park WR	-
19083193	The role of HSP70 on ENPP1 expression and insulin-receptor activation.	J Mol Med (Berl)	2009 Feb	Marucci A	doi: 10.1007/s00109-008-0429-9
21763498	Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70.	J Mol Biol	2011 Jul 29	Kumar M	doi: 10.1016/j.jmb.2011.04.005.
21739554	Label-free nondestructive discrimination of colon carcinoma sublines and biomolecular insights into their differential Hsp70 expression: DNA/RNA nucleobase specific changes.	Chembiochem	2011 Aug 16	Donfack P	doi: 10.1002/cbic.201000653
21390211	Heat shock protein 70 inhibits the activity of Influenza A virus ribonucleoprotein and blocks the replication of virus in vitro and in vivo.	PLoS One	2011 Feb 24	Li G	doi: 10.1371/journal.pone.0016546.
25253355	DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.	J Virol	2014 Dec	Cao M	doi: 10.1128/JVI.02475-14
23667540	N,N'-dinitrosopiperazine--mediated heat-shock protein 70-2 expression is involved in metastasis of nasopharyngeal carcinoma.	PLoS One	2013 May 7	Peng Z	doi: 10.1371/journal.pone.0062908
30508278	Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.	Proteomics	2018 Dec	Manissorn J	doi: 10.1002/pmic.201800004.
30975014	Autophagy in Xenopus laevis rod photoreceptors is independently regulated by phototransduction and misfolded RHOP23H.	Autophagy	2019 Apr 12:1-20	Wen RH	doi: 10.1080/15548627.2019.1596487

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504328	HSPA4-202	552	-	-	- (aa)	-	-
ENST00000514825	HSPA4-203	690	-	-	- (aa)	-	-
ENST00000617074	HSPA4-205	2358	-	ENSP00000481686	699 (aa)	-	A0A087WYC1
ENST00000304858	HSPA4-201	4825	-	ENSP00000302961	840 (aa)	-	P34932
ENST00000615899	HSPA4-204	2204	-	ENSP00000478102	475 (aa)	-	A0A087WTS8

Gene Model

Click here to download ENSG00000170606's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa04612	Antigen processing and presentation	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000170606	Blood Pressure	3.2952171E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000170606	rs147133967	5	133091160	G	Reticulocyte fraction of red cells	27863252	[0.024-0.048] unit increase	0.03596435	EFO_0007986
ENSG00000170606	rs571173399	5	133106107	?	Heel bone mineral density	30048462	[0.019-0.029] unit decrease	0.0242276	EFO_0009270
ENSG00000170606	rs72801445	5	133053267	C	Heel bone mineral density	30598549	[0.015-0.024] unit decrease	0.0196744	EFO_0009270
ENSG00000170606	rs55747751	5	133061659	A	Diastolic blood pressure	30224653	[0.16-0.27] mmHg decrease	0.2159	EFO_0006336
ENSG00000170606	rs140767284	5	133090504	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000170606	rs6596100	5	133071366	C	Breast cancer	29059683	[1.04-1.09] (Oncoarray)	1.0638298	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170606's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	22990239.25416956.29568061.30021884.	IPI	Function
GO:0005524	ATP binding	8335910.	NAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	21231916.	IDA	Component
GO:0006986	response to unfolded protein	8335910.	NAS	Process
GO:0045040	protein import into mitochondrial outer membrane	15644312.	IDA	Process
GO:0051131	chaperone-mediated protein complex assembly	15644312.	IDA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0070062	extracellular exosome	21276792.	IDA	Component

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.