EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23283744	Down-regulation of the ErbB3 binding protein 1 in human bladder cancer promotes tumor progression and cell proliferation.	Mol Biol Rep	2013 May	He HC	doi: 10.1007/s11033-012-2458-2
28209614	Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.	Cancer Res	2017 Apr 15	Wang Y	doi: 10.1158/0008-5472.CAN-16-2246
19037095	Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.	Mol Biol Cell	2009 Feb	Liu Z	doi: 10.1091/mbc.E08-09-0983
26081906	EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.	Int J Oncol	2015 Aug	Pisapia L	doi: 10.3892/ijo.2015.3051
25917452	A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level.	Mol Cell Endocrinol	2015 Aug 15	Zhang F	doi: 10.1016/j.mce.2015.04.013
18852121	EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance.	Mol Cancer Ther	2008 Oct	Zhang Y	doi: 10.1158/1535-7163.MCT-08-0526.
24798454	Androgen receptor (AR) inhibitor ErbB3-binding protein-1 (Ebp1) is not targeted by the newly identified AR controlling signaling axis heat-shock protein HSP27 and microRNA miR-1 in prostate cancer cells.	World J Urol	2015 Mar	Stope MB	doi: 10.1007/s00345-014-1307-4
26436510	Significance of Ebp1 and p53 protein expression in cervical cancer.	Genet Mol Res	2015 Oct 2	Liu L	doi: 10.4238/2015.October.2.19.
20048076	ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.	Cancer Res	2010 Jan 1	Zhang Y	doi: 10.1158/0008-5472.CAN-09-2904.
18355957	Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1.	Cancer Lett	2008 Jul 8	Zhang Y	doi: 10.1016/j.canlet.2008.02.024
21965718	EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells.	Anticancer Res	2011 Oct	Zhou H	-
20379846	The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells.	Breast Cancer Res Treat	2011 Feb	Lu Y	doi: 10.1007/s10549-010-0873-4
15994225	The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.	Proc Natl Acad Sci U S A	2005 Jul 12	Zhang Y	-
23110497	Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance.	BMC Cancer	2012 Oct 30	Sun J	doi: 10.1186/1471-2407-12-499.
17641068	Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.	J Immunol	2007 Aug 1	Santegoets SJ	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	56110421	Missense_Mutation	novel	F218I	0.04
ACC	chr12	56110681	Silent	rs145895424	P277P	0.49
BLCA	chr12	56104702	5'UTR	rs753074063		0.32
BLCA	chr12	56110670	Missense_Mutation	novel	D274N	0.29
BLCA	chr12	56111511	Missense_Mutation	NA	Q367H	0.21
BLCA	chr12	56107020	Missense_Mutation	NA	N83S	0.28
BLCA	chr12	56104571	5'UTR	novel		0.33
BLCA	chr12	56104702	5'UTR	novel		0.49
BLCA	chr12	56110670	Missense_Mutation	novel	D274N	0.4
BLCA	chr12	56104635	5'UTR	novel		0.56
BLCA	chr12	56111254	Missense_Mutation	novel	P337R	0.53
BLCA	chr12	56104587	5'UTR	novel		0.27
BRCA	chr12	56109905	Missense_Mutation	NA	T200N	0.39
BRCA	chr12	56110578	Missense_Mutation	novel	R243K	0.08
BRCA	chr12	56110645	Missense_Mutation	NA	F265L	0.35
BRCA	chr12	56110989	Missense_Mutation	NA	R290G	0.35
BRCA	chr12	56107541	Silent	novel	R138R	0.05
BRCA	chr12	56104615	5'UTR	novel		0.23
CESC	chr12	56109896	Missense_Mutation	NA	G197A	0.34
CESC	chr12	56110602	Missense_Mutation	NA	P251L	0.46
CESC	chr12	56104638	5'UTR	novel		0.31
CESC	chr12	56110464	Nonsense_Mutation	NA	S232*	0.13
CESC	chr12	56107184	Splice_Region	novel		0.33
COAD	chr12	56112994	3'UTR	novel		0.36
COAD	chr12	56109899	Frame_Shift_Del	NA	*T200Pfs58**	0.29
COAD	chr12	56111517	Frame_Shift_Ins	novel	*K373Efs19**	0.43
ESCA	chr12	56104456	5'UTR	novel		0.17
ESCA	chr12	56111512	Frame_Shift_Del	novel	*K369Rfs19**	0.38
GBM	chr12	56107255	Missense_Mutation	NA	Q131R	0.22
GBM	chr12	56104788	Silent	novel	V17V	0.45
GBM	chr12	56111264	Silent	novel	P340P	0.09
GBM	chr12	56110650	Missense_Mutation	novel	S267I	0.04
HNSC	chr12	56111511	Missense_Mutation	NA	Q367H	0.16
HNSC	chr12	56112872	Missense_Mutation	novel	N390S	0.3
HNSC	chr12	56112901	3'UTR	novel		0.32
HNSC	chr12	56110424	Missense_Mutation	novel	E219K	0.12
HNSC	chr12	56104806	Missense_Mutation	rs144476801	M23I	0.16
HNSC	chr12	56110478	Splice_Site	novel	X236_splice	0.05
HNSC	chr12	56110433	Nonsense_Mutation	novel	E222*	0.16
KIRP	chr12	56104452	5'UTR	novel		0.4
LGG	chr12	56110456	Silent	rs761782091	L229L	0.43
LGG	chr12	56110561	Splice_Region	NA	A237A	0.43
LGG	chr12	56110989	Missense_Mutation	NA	R290W	0.19
LGG	chr12	56107535	Silent	NA	T136T	0.14
LGG	chr12	56111227	Missense_Mutation	rs762145974	N328S	0.28
LUAD	chr12	56107070	Missense_Mutation	novel	L100F	0.06
LUAD	chr12	56107072	Silent	novel	L100L	0.06
LUAD	chr12	56104715	5'UTR	novel		0.21
LUSC	chr12	56106713	Nonsense_Mutation	NA	K72*	0.11
LUSC	chr12	56112890	3'UTR	rs144230100		0.25
LUSC	chr12	56112937	3'UTR	novel		0.44
LUSC	chr12	56110652	Missense_Mutation	NA	E268K	0.16
LUSC	chr12	56107065	Missense_Mutation	novel	Y98C	0.11
LUSC	chr12	56110411	Silent	novel	E214E	0.29
LUSC	chr12	56112840	Missense_Mutation	novel	E379D	0.19
LUSC	chr12	56104615	5'UTR	novel		0.17
OV	chr12	56104686	5'UTR	novel		0.28
PAAD	chr12	56111246	Silent	novel	T334T	0.17
READ	chr12	56110578	Missense_Mutation	NA	R243I	0.25
SARC	chr12	56104581	5'UTR	novel		0.47
SKCM	chr12	56111500	Nonsense_Mutation	novel	R364*	0.35
SKCM	chr12	56110452	Missense_Mutation	NA	V228A	0.35
SKCM	chr12	56110603	Silent	NA	P251P	0.3
SKCM	chr12	56112904	3'UTR	novel		0.13
STAD	chr12	56111517	Frame_Shift_Ins	novel	*K373Efs19**	0.26
STAD	chr12	56111517	Frame_Shift_Ins	novel	*K373Efs19**	0.25
STAD	chr12	56111216	Silent	NA	L324L	0.4
STAD	chr12	56110664	Missense_Mutation	NA	R272C	0.12
STAD	chr12	56112920	3'UTR	novel		0.17
STAD	chr12	56111224	Missense_Mutation	NA	P327H	0.19
TGCT	chr12	56107605	Missense_Mutation	novel	G160R	0.07
TGCT	chr12	56111484	Silent	novel	L358L	0.31
UCEC	chr12	56111526	Missense_Mutation	NA	K372N	0.35
UCEC	chr12	56110965	Missense_Mutation	novel	A282T	0.19
UCEC	chr12	56109892	Missense_Mutation	NA	D196Y	0.14
UCEC	chr12	56111188	Missense_Mutation	novel	F315C	0.38
UCEC	chr12	56110474	Silent	novel	G235G	0.41
UCEC	chr12	56110578	Missense_Mutation	NA	R243I	0.36
UCEC	chr12	56107234	Missense_Mutation	novel	T124I	0.03
UCEC	chr12	56111501	Missense_Mutation	novel	R364Q	0.23
UCEC	chr12	56113123	3'UTR	novel		0.45
UCEC	chr12	56104419	5'UTR	novel		0.33
UCEC	chr12	56107612	Missense_Mutation	novel	Q162R	0.21
UCEC	chr12	56111518	Frame_Shift_Del	rs746871475	*K372Rfs16**	0.31
UCEC	chr12	56110584	Missense_Mutation	novel	T245I	0.38
UCEC	chr12	56111500	Nonsense_Mutation	novel	R364*	0.31
UCEC	chr12	56109905	Missense_Mutation	NA	T200N	0.51
UCEC	chr12	56112952	3'UTR	novel		0.45
UCEC	chr12	56104697	5'UTR	rs755490040		0.36
UCEC	chr12	56110680	Missense_Mutation	novel	P277L	0.26
UCEC	chr12	56113029	3'UTR	novel		0.36
UCEC	chr12	56112880	Frame_Shift_Del	novel	*D394Tfs32**	0.46
UCEC	chr12	56110595	Nonsense_Mutation	NA	R249*	0.32
UCEC	chr12	56112994	3'UTR	novel		0.14
UCEC	chr12	56109899	Frame_Shift_Del	NA	*T200Pfs58**	0.37
UCEC	chr12	56107591	Missense_Mutation	novel	R155H	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
DLBC	AMP	0.2083	0.085003
PCPG	AMP	0.0802	0.028953
READ	DEL	0.0727	0.064633

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0042	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
SKCM	0.00037	Kaplan-Meier Survival Analysis
ESCA	0.0038	Kaplan-Meier Survival Analysis
KIRP	0.0017	Kaplan-Meier Survival Analysis
PAAD	0.042	Kaplan-Meier Survival Analysis
BLCA	0.044	Kaplan-Meier Survival Analysis
KICH	0.02	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0032	Kaplan-Meier Survival Analysis
LUAD	0.0012	Kaplan-Meier Survival Analysis
OV	0.0055	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000170515 (Gene tree)
Gene ID: 5036
Gene Symbol: PA2G4
Alias: N
Full Name: proliferation-associated 2G4
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 9,592 bases
Position: chr12:56,104,319-56,113,910
Accession: 8550
Summary: This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19094237	Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.	BMC Cell Biol	2008 Dec 18	Zhang Y	doi: 10.1186/1471-2121-9-69.
21624892	EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon.	Nucleic Acids Res	2011 Sep 1	Corso C	doi: 10.1093/nar/gkr278
26256794	ErbB3 binding protein 1 (EBP1) participates in the regulation of intestinal inflammation via mediating Akt signaling pathway.	Mol Immunol	2015 Oct	Miao X	doi: 10.1016/j.molimm.2015.07.032.
20159994	Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer.	Nucleic Acids Res	2010 Jun	Zhou H	doi: 10.1093/nar/gkq084
19946338	Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity.	Oncogene	2010 Feb 18	Oh SM	doi: 10.1038/onc.2009.411
17690690	Structural insights into the transcriptional and translational roles of Ebp1.	EMBO J	2007 Sep 5	Monie TP	-
24275324	ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.	Dev Biol	2014 Feb 1	Figeac N	doi: 10.1016/j.ydbio.2013.11.017
23840586	Expression of ErbB3-binding protein-1 (EBP1) during primordial follicle formation: role of estradiol-17.	PLoS One	2013 Jun 20	Mukherjee A	doi: 10.1371/journal.pone.0067068
17295834	Host factor Ebp1: selective inhibitor of influenza virus transcriptase.	Genes Cells	2007 Feb	Honda A	-
19159951	Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.	Langenbecks Arch Surg	2010 Mar	Daigeler A	doi: 10.1007/s00423-009-0465-0
26813358	Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells.	Clin Cancer Res	2016 Jul 1	Nguyen le XT	doi: 10.1158/1078-0432.CCR-15-2282
25883228	TIF-IA and Ebp1 regulate RNA synthesis in T cells.	Blood	2015 Apr 16	Saudemont A	doi: 10.1182/blood-2015-03-630780.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000552528	PA2G4-205	289	-	-	- (aa)	-	-
ENST00000550166	PA2G4-202	520	-	-	- (aa)	-	-
ENST00000552266	PA2G4-204	779	-	-	- (aa)	-	-
ENST00000553057	PA2G4-207	687	-	ENSP00000447615	187 (aa)	-	F8W0A3
ENST00000552766	PA2G4-206	1085	-	ENSP00000448557	284 (aa)	-	F8VR77
ENST00000303305	PA2G4-201	2577	-	ENSP00000302886	394 (aa)	-	Q9UQ80
ENST00000551061	PA2G4-203	694	-	ENSP00000447389	64 (aa)	-	F8VZ69

Gene Model

Click here to download ENSG00000170515's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000170515	Alzheimer Disease	7E-8	26830138
ENSG00000170515	Age of Onset	7E-8	26830138

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170515's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000170515	PA2G4	98	87.302	ENSDARG00000039578	pa2g4a	97	86.280	Danio_rerio
ENSG00000170515	PA2G4	100	100.000	ENSMUSG00000025364	Pa2g4	100	98.985	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	21873635.	IBA	Function
GO:0003677	DNA binding	15073182.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	15073182.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	11268000.15064750.16254079.16832058.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	15073182.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	16832058.19037095.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	16832058.19037095.	IDA	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0006417	regulation of translation	-	IEA	Process
GO:0007050	cell cycle arrest	7556453.	TAS	Process
GO:0008283	cell proliferation	7556453.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031625	ubiquitin protein ligase binding	19037095.	IPI	Function
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043066	negative regulation of apoptotic process	-	ISS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045597	positive regulation of cell differentiation	-	ISS	Process
GO:0045892	negative regulation of transcription, DNA-templated	15073182.	IDA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.