EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23283744Down-regulation of the ErbB3 binding protein 1 in human bladder cancer promotes tumor progression and cell proliferation.Mol Biol Rep2013 MayHe HCdoi: 10.1007/s11033-012-2458-2
28209614Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.Cancer Res2017 Apr 15Wang Ydoi: 10.1158/0008-5472.CAN-16-2246
19037095Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.Mol Biol Cell2009 FebLiu Zdoi: 10.1091/mbc.E08-09-0983
26081906EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.Int J Oncol2015 AugPisapia Ldoi: 10.3892/ijo.2015.3051
25917452A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level.Mol Cell Endocrinol2015 Aug 15Zhang Fdoi: 10.1016/j.mce.2015.04.013
18852121EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance.Mol Cancer Ther2008 OctZhang Ydoi: 10.1158/1535-7163.MCT-08-0526.
24798454Androgen receptor (AR) inhibitor ErbB3-binding protein-1 (Ebp1) is not targeted by the newly identified AR controlling signaling axis heat-shock protein HSP27 and microRNA miR-1 in prostate cancer cells.World J Urol2015 MarStope MBdoi: 10.1007/s00345-014-1307-4
26436510Significance of Ebp1 and p53 protein expression in cervical cancer.Genet Mol Res2015 Oct 2Liu Ldoi: 10.4238/2015.October.2.19.
20048076ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.Cancer Res2010 Jan 1Zhang Ydoi: 10.1158/0008-5472.CAN-09-2904.
18355957Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1.Cancer Lett2008 Jul 8Zhang Ydoi: 10.1016/j.canlet.2008.02.024
21965718EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells.Anticancer Res2011 OctZhou H-
20379846The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells.Breast Cancer Res Treat2011 FebLu Ydoi: 10.1007/s10549-010-0873-4
15994225The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.Proc Natl Acad Sci U S A2005 Jul 12Zhang Y-
23110497Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance.BMC Cancer2012 Oct 30Sun Jdoi: 10.1186/1471-2407-12-499.
17641068Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.J Immunol2007 Aug 1Santegoets SJ-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1256110421Missense_MutationnovelF218I0.04
ACCchr1256110681Silentrs145895424P277P0.49
BLCAchr12561047025'UTRrs7530740630.32
BLCAchr1256110670Missense_MutationnovelD274N0.29
BLCAchr1256111511Missense_MutationNAQ367H0.21
BLCAchr1256107020Missense_MutationNAN83S0.28
BLCAchr12561045715'UTRnovel0.33
BLCAchr12561047025'UTRnovel0.49
BLCAchr1256110670Missense_MutationnovelD274N0.4
BLCAchr12561046355'UTRnovel0.56
BLCAchr1256111254Missense_MutationnovelP337R0.53
BLCAchr12561045875'UTRnovel0.27
BRCAchr1256109905Missense_MutationNAT200N0.39
BRCAchr1256110578Missense_MutationnovelR243K0.08
BRCAchr1256110645Missense_MutationNAF265L0.35
BRCAchr1256110989Missense_MutationNAR290G0.35
BRCAchr1256107541SilentnovelR138R0.05
BRCAchr12561046155'UTRnovel0.23
CESCchr1256109896Missense_MutationNAG197A0.34
CESCchr1256110602Missense_MutationNAP251L0.46
CESCchr12561046385'UTRnovel0.31
CESCchr1256110464Nonsense_MutationNAS232*0.13
CESCchr1256107184Splice_Regionnovel0.33
COADchr12561129943'UTRnovel0.36
COADchr1256109899Frame_Shift_DelNAT200Pfs*580.29
COADchr1256111517Frame_Shift_InsnovelK373Efs*190.43
ESCAchr12561044565'UTRnovel0.17
ESCAchr1256111512Frame_Shift_DelnovelK369Rfs*190.38
GBMchr1256107255Missense_MutationNAQ131R0.22
GBMchr1256104788SilentnovelV17V0.45
GBMchr1256111264SilentnovelP340P0.09
GBMchr1256110650Missense_MutationnovelS267I0.04
HNSCchr1256111511Missense_MutationNAQ367H0.16
HNSCchr1256112872Missense_MutationnovelN390S0.3
HNSCchr12561129013'UTRnovel0.32
HNSCchr1256110424Missense_MutationnovelE219K0.12
HNSCchr1256104806Missense_Mutationrs144476801M23I0.16
HNSCchr1256110478Splice_SitenovelX236_splice0.05
HNSCchr1256110433Nonsense_MutationnovelE222*0.16
KIRPchr12561044525'UTRnovel0.4
LGGchr1256110456Silentrs761782091L229L0.43
LGGchr1256110561Splice_RegionNAA237A0.43
LGGchr1256110989Missense_MutationNAR290W0.19
LGGchr1256107535SilentNAT136T0.14
LGGchr1256111227Missense_Mutationrs762145974N328S0.28
LUADchr1256107070Missense_MutationnovelL100F0.06
LUADchr1256107072SilentnovelL100L0.06
LUADchr12561047155'UTRnovel0.21
LUSCchr1256106713Nonsense_MutationNAK72*0.11
LUSCchr12561128903'UTRrs1442301000.25
LUSCchr12561129373'UTRnovel0.44
LUSCchr1256110652Missense_MutationNAE268K0.16
LUSCchr1256107065Missense_MutationnovelY98C0.11
LUSCchr1256110411SilentnovelE214E0.29
LUSCchr1256112840Missense_MutationnovelE379D0.19
LUSCchr12561046155'UTRnovel0.17
OVchr12561046865'UTRnovel0.28
PAADchr1256111246SilentnovelT334T0.17
READchr1256110578Missense_MutationNAR243I0.25
SARCchr12561045815'UTRnovel0.47
SKCMchr1256111500Nonsense_MutationnovelR364*0.35
SKCMchr1256110452Missense_MutationNAV228A0.35
SKCMchr1256110603SilentNAP251P0.3
SKCMchr12561129043'UTRnovel0.13
STADchr1256111517Frame_Shift_InsnovelK373Efs*190.26
STADchr1256111517Frame_Shift_InsnovelK373Efs*190.25
STADchr1256111216SilentNAL324L0.4
STADchr1256110664Missense_MutationNAR272C0.12
STADchr12561129203'UTRnovel0.17
STADchr1256111224Missense_MutationNAP327H0.19
TGCTchr1256107605Missense_MutationnovelG160R0.07
TGCTchr1256111484SilentnovelL358L0.31
UCECchr1256111526Missense_MutationNAK372N0.35
UCECchr1256110965Missense_MutationnovelA282T0.19
UCECchr1256109892Missense_MutationNAD196Y0.14
UCECchr1256111188Missense_MutationnovelF315C0.38
UCECchr1256110474SilentnovelG235G0.41
UCECchr1256110578Missense_MutationNAR243I0.36
UCECchr1256107234Missense_MutationnovelT124I0.03
UCECchr1256111501Missense_MutationnovelR364Q0.23
UCECchr12561131233'UTRnovel0.45
UCECchr12561044195'UTRnovel0.33
UCECchr1256107612Missense_MutationnovelQ162R0.21
UCECchr1256111518Frame_Shift_Delrs746871475K372Rfs*160.31
UCECchr1256110584Missense_MutationnovelT245I0.38
UCECchr1256111500Nonsense_MutationnovelR364*0.31
UCECchr1256109905Missense_MutationNAT200N0.51
UCECchr12561129523'UTRnovel0.45
UCECchr12561046975'UTRrs7554900400.36
UCECchr1256110680Missense_MutationnovelP277L0.26
UCECchr12561130293'UTRnovel0.36
UCECchr1256112880Frame_Shift_DelnovelD394Tfs*320.46
UCECchr1256110595Nonsense_MutationNAR249*0.32
UCECchr12561129943'UTRnovel0.14
UCECchr1256109899Frame_Shift_DelNAT200Pfs*580.37
UCECchr1256107591Missense_MutationnovelR155H0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.02220.20414
DLBCAMP0.20830.085003
PCPGAMP0.08020.028953
READDEL0.07270.064633

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.0042

Kaplan-Meier Survival Analysis

ACC0.00018

Kaplan-Meier Survival Analysis

SKCM0.00037

Kaplan-Meier Survival Analysis

ESCA0.0038

Kaplan-Meier Survival Analysis

KIRP0.0017

Kaplan-Meier Survival Analysis

PAAD0.042

Kaplan-Meier Survival Analysis

BLCA0.044

Kaplan-Meier Survival Analysis

KICH0.02

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.0032

Kaplan-Meier Survival Analysis

LUAD0.0012

Kaplan-Meier Survival Analysis

OV0.0055

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000170515 (Gene tree)
Gene ID
5036
Gene Symbol
PA2G4
Alias
N
Full Name
proliferation-associated 2G4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
9,592 bases
Position
chr12:56,104,319-56,113,910
Accession
8550
RBP type
non-canonical RBP
Summary
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19094237Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.BMC Cell Biol2008 Dec 18Zhang Ydoi: 10.1186/1471-2121-9-69.
21624892EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon.Nucleic Acids Res2011 Sep 1Corso Cdoi: 10.1093/nar/gkr278
26256794ErbB3 binding protein 1 (EBP1) participates in the regulation of intestinal inflammation via mediating Akt signaling pathway.Mol Immunol2015 OctMiao Xdoi: 10.1016/j.molimm.2015.07.032.
20159994Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer.Nucleic Acids Res2010 JunZhou Hdoi: 10.1093/nar/gkq084
19946338Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity.Oncogene2010 Feb 18Oh SMdoi: 10.1038/onc.2009.411
17690690Structural insights into the transcriptional and translational roles of Ebp1.EMBO J2007 Sep 5Monie TP-
24275324ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.Dev Biol2014 Feb 1Figeac Ndoi: 10.1016/j.ydbio.2013.11.017
23840586Expression of ErbB3-binding protein-1 (EBP1) during primordial follicle formation: role of estradiol-17.PLoS One2013 Jun 20Mukherjee Adoi: 10.1371/journal.pone.0067068
17295834Host factor Ebp1: selective inhibitor of influenza virus transcriptase.Genes Cells2007 FebHonda A-
19159951Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.Langenbecks Arch Surg2010 MarDaigeler Adoi: 10.1007/s00423-009-0465-0
26813358Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells.Clin Cancer Res2016 Jul 1Nguyen le XTdoi: 10.1158/1078-0432.CCR-15-2282
25883228TIF-IA and Ebp1 regulate RNA synthesis in T cells.Blood2015 Apr 16Saudemont Adoi: 10.1182/blood-2015-03-630780.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000552528PA2G4-205289--- (aa)--
ENST00000550166PA2G4-202520--- (aa)--
ENST00000552266PA2G4-204779--- (aa)--
ENST00000553057PA2G4-207687-ENSP00000447615187 (aa)-F8W0A3
ENST00000552766PA2G4-2061085-ENSP00000448557284 (aa)-F8VR77
ENST00000303305PA2G4-2012577-ENSP00000302886394 (aa)-Q9UQ80
ENST00000551061PA2G4-203694-ENSP0000044738964 (aa)-F8VZ69
Gene Model
Click here to download ENSG00000170515's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000170515Alzheimer Disease7E-826830138
ENSG00000170515Age of Onset7E-826830138
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170515's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000170515PA2G49887.302ENSDARG00000039578pa2g4a9786.280Danio_rerio
ENSG00000170515PA2G4100100.000ENSMUSG00000025364Pa2g410098.985Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003676nucleic acid binding21873635.IBAFunction
GO:0003677DNA binding15073182.IDAFunction
GO:0003700DNA-binding transcription factor activity15073182.IDAFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding11268000.15064750.16254079.16832058.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus15073182.IDAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus16832058.19037095.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm16832058.19037095.IDAComponent
GO:0006364rRNA processing-IEAProcess
GO:0006417regulation of translation-IEAProcess
GO:0007050cell cycle arrest7556453.TASProcess
GO:0008283cell proliferation7556453.TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0031625ubiquitin protein ligase binding19037095.IPIFunction
GO:0035578azurophil granule lumen-TASComponent
GO:0043066negative regulation of apoptotic process-ISSProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0045597positive regulation of cell differentiation-ISSProcess
GO:0045892negative regulation of transcription, DNA-templated15073182.IDAProcess
GO:0070062extracellular exosome20458337.HDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us