EuRBPDB

Ensembl ID

ENSG00000168918 (Gene tree)

Gene ID

3635

Gene Symbol

INPP5D

Alias

SHIP|hp51CN|SHIP1

Full Name

inositol polyphosphate-5-phosphatase D

Gene Type

protein_coding

Specie

Homo_sapiens

Strand

Plus strand

Length

147,937 bases

Position

chr2:233,059,967-233,207,903

Accession

6079

Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]